locus-tag	class	description
CDHC02_RS00010	COG0592	DNA-directed DNA polymerase activity
CDHC02_RS00025	COG0187	DNA topoisomerase II activity
CDHC02_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CDHC02_RS00070	COG1620	l-lactate permease
CDHC02_RS00080	COG4988	ABC transporter
CDHC02_RS00130	COG4211	Belongs to the binding-protein-dependent transport system permease family
CDHC02_RS00175	COG0352	thiamine-phosphate diphosphorylase activity
CDHC02_RS00180	COG2022	thiamine diphosphate biosynthetic process
CDHC02_RS00180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDHC02_RS00200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CDHC02_RS00200	COG0352	thiamine-phosphate diphosphorylase activity
CDHC02_RS00200	COG0351	phosphomethylpyrimidine kinase
CDHC02_RS00245	COG0515	serine threonine protein kinase
CDHC02_RS00245	COG2815	serine threonine protein kinase
CDHC02_RS00250	COG0515	serine threonine protein kinase
CDHC02_RS00255	COG0768	penicillin binding
CDHC02_RS00275	COG1716	ATPase activity
CDHC02_RS00275	COG1716	ATPase activity
CDHC02_RS00305	COG2205	protein histidine kinase activity
CDHC02_RS00310	COG0745	RESPONSE REGULATOR receiver
CDHC02_RS00320	COG2132	Multicopper oxidase
CDHC02_RS00350	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS00375	COG0789	Transcriptional regulator
CDHC02_RS00390	COG2076	Multidrug Resistance protein
CDHC02_RS00405	COG2072	flavoprotein involved in K transport
CDHC02_RS00415	COG0798	PFAM Bile acid sodium symporter
CDHC02_RS00420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDHC02_RS00435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDHC02_RS00440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDHC02_RS00490	COG1131	(ABC) transporter
CDHC02_RS00495	COG2197	response regulator
CDHC02_RS00500	COG4585	Histidine kinase
CDHC02_RS00510	COG1174	glycine betaine transport
CDHC02_RS00515	COG1174	glycine betaine transport
CDHC02_RS00520	COG0517	IMP dehydrogenase activity
CDHC02_RS00520	COG1125	glycine betaine transport
CDHC02_RS00530	COG1595	DNA-templated transcription, initiation
CDHC02_RS00545	COG0789	Transcriptional regulator
CDHC02_RS00550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDHC02_RS00570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDHC02_RS00575	COG1120	ATPase activity
CDHC02_RS00585	COG5646	InterPro IPR014922
CDHC02_RS00590	COG0415	Belongs to the DNA photolyase family
CDHC02_RS00625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDHC02_RS00650	COG1846	Transcriptional regulator
CDHC02_RS00655	COG3180	Ammonia monooxygenase
CDHC02_RS00670	COG1643	Atp-dependent helicase
CDHC02_RS00760	COG2501	S4 domain
CDHC02_RS00785	COG3590	peptidase
CDHC02_RS00820	COG1028	Short-chain dehydrogenase reductase Sdr
CDHC02_RS00825	COG0277	FAD linked oxidase domain protein
CDHC02_RS00855	COG1216	Glycosyl transferase, family 2
CDHC02_RS00860	COG0803	Belongs to the bacterial solute-binding protein 9 family
CDHC02_RS00865	COG1121	(ABC) transporter
CDHC02_RS00870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDHC02_RS00875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDHC02_RS00880	COG0803	Belongs to the bacterial solute-binding protein 9 family
CDHC02_RS00900	COG0604	alcohol dehydrogenase
CDHC02_RS00940	COG0726	polysaccharide deacetylase
CDHC02_RS00945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDHC02_RS00965	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS01015	COG0287	Prephenate dehydrogenase
CDHC02_RS01045	COG2409	Drug exporters of the RND superfamily
CDHC02_RS01050	COG0343	queuine tRNA-ribosyltransferase activity
CDHC02_RS01060	COG2610	gluconate transmembrane transporter activity
CDHC02_RS01065	COG3265	gluconokinase activity
CDHC02_RS01070	COG1063	alcohol dehydrogenase
CDHC02_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
CDHC02_RS01085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDHC02_RS01110	COG1492	cobalamin metabolic process
CDHC02_RS01115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CDHC02_RS01130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDHC02_RS01135	COG2390	Transcriptional regulator
CDHC02_RS01155	COG2814	Major facilitator Superfamily
CDHC02_RS01165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDHC02_RS01175	COG0697	spore germination
CDHC02_RS01180	COG0527	aspartate kinase activity
CDHC02_RS01255	COG2271	Major facilitator Superfamily
CDHC02_RS01260	COG0745	RESPONSE REGULATOR receiver
CDHC02_RS01285	COG0651	ATP synthesis coupled electron transport
CDHC02_RS01290	COG1006	Multisubunit Na H antiporter MnhC subunit
CDHC02_RS01295	COG2111	Na H antiporter
CDHC02_RS01295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDHC02_RS01325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDHC02_RS01340	COG0251	oxidation-reduction process
CDHC02_RS01345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDHC02_RS01350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDHC02_RS01430	COG1111	helicase
CDHC02_RS01430	COG1205	dead DEAH box helicase
CDHC02_RS01435	COG1278	Cold shock
CDHC02_RS01440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDHC02_RS01445	COG3842	ATPase activity
CDHC02_RS01465	COG0702	epimerase
CDHC02_RS01470	COG1754	DNA topoisomerase type I activity
CDHC02_RS01470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDHC02_RS01480	COG1297	OPT oligopeptide transporter protein
CDHC02_RS01515	COG4974	Belongs to the 'phage' integrase family
CDHC02_RS01540	COG3177	Filamentation induced by cAMP protein fic
CDHC02_RS01565	COG0318	PFAM AMP-dependent synthetase and ligase
CDHC02_RS01575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CDHC02_RS01585	COG1088	dTDP-glucose 4,6-dehydratase activity
CDHC02_RS01595	COG1505	serine-type exopeptidase activity
CDHC02_RS01605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDHC02_RS01610	COG3800	Transcriptional regulator
CDHC02_RS01610	COG1396	sequence-specific DNA binding
CDHC02_RS01620	COG1053	succinate dehydrogenase
CDHC02_RS01625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDHC02_RS01635	COG2733	membrane
CDHC02_RS01645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CDHC02_RS01655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CDHC02_RS01665	COG1882	Formate acetyltransferase
CDHC02_RS01685	COG0318	PFAM AMP-dependent synthetase and ligase
CDHC02_RS01690	COG0318	PFAM AMP-dependent synthetase and ligase
CDHC02_RS01705	COG5002	protein histidine kinase activity
CDHC02_RS01725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CDHC02_RS01735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CDHC02_RS01735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDHC02_RS01760	COG1648	precorrin-2 dehydrogenase activity
CDHC02_RS01760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDHC02_RS01765	COG0113	porphobilinogen synthase activity
CDHC02_RS01800	COG0406	alpha-ribazole phosphatase activity
CDHC02_RS01810	COG0785	Cytochrome C biogenesis protein
CDHC02_RS01820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDHC02_RS01855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CDHC02_RS01860	COG4948	Mandelate Racemase Muconate Lactonizing
CDHC02_RS01875	COG0438	transferase activity, transferring glycosyl groups
CDHC02_RS01875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDHC02_RS01880	COG2226	methyltransferase
CDHC02_RS01885	COG0039	L-malate dehydrogenase activity
CDHC02_RS01890	COG0644	oxidoreductase
CDHC02_RS01895	COG0142	geranyltranstransferase activity
CDHC02_RS01920	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDHC02_RS01960	COG1121	(ABC) transporter
CDHC02_RS01965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDHC02_RS02025	COG2801	Transposase and inactivated derivatives
CDHC02_RS02050	COG4585	Histidine kinase
CDHC02_RS02055	COG2197	response regulator
CDHC02_RS02060	COG1131	(ABC) transporter
CDHC02_RS02075	COG0701	Predicted permease
CDHC02_RS02120	COG0051	transcription antitermination factor activity, RNA binding
CDHC02_RS02180	COG1136	(ABC) transporter
CDHC02_RS02185	COG0577	efflux transmembrane transporter activity
CDHC02_RS02205	COG0814	amino acid
CDHC02_RS02210	COG1760	l-serine dehydratase
CDHC02_RS02215	COG0252	asparaginase activity
CDHC02_RS02225	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDHC02_RS02255	COG1140	nitrate reductase beta subunit
CDHC02_RS02280	COG0746	molybdenum cofactor guanylyltransferase activity
CDHC02_RS02285	COG0315	cyclic pyranopterin monophosphate synthase activity
CDHC02_RS02300	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS02310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDHC02_RS02320	COG0444	Belongs to the ABC transporter superfamily
CDHC02_RS02325	COG0601	transmembrane transport
CDHC02_RS02330	COG0747	negative chemotaxis
CDHC02_RS02335	COG2186	Transcriptional regulator
CDHC02_RS02350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CDHC02_RS02410	COG0366	Alpha amylase catalytic
CDHC02_RS02425	COG1175	transmembrane transport
CDHC02_RS02430	COG3833	ABC-type maltose transport systems, permease component
CDHC02_RS02445	COG3842	ATPase activity
CDHC02_RS02450	COG0201	protein transport
CDHC02_RS02530	COG1674	ftsk spoiiie
CDHC02_RS02585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDHC02_RS02610	COG0456	acetyltransferase
CDHC02_RS02650	COG0516	GMP reductase activity
CDHC02_RS02655	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CDHC02_RS02660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDHC02_RS02665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDHC02_RS02670	COG1120	ATPase activity
CDHC02_RS02770	COG0668	transmembrane transport
CDHC02_RS02775	COG2011	ABC-type metal ion transport system permease component
CDHC02_RS02790	COG1464	Belongs to the NlpA lipoprotein family
CDHC02_RS02810	COG0803	Belongs to the bacterial solute-binding protein 9 family
CDHC02_RS02815	COG1121	(ABC) transporter
CDHC02_RS02850	COG2801	Transposase and inactivated derivatives
CDHC02_RS02885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDHC02_RS02890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CDHC02_RS02900	COG2873	o-acetylhomoserine
CDHC02_RS02905	COG2838	Isocitrate dehydrogenase
CDHC02_RS02910	COG2814	Major facilitator Superfamily
CDHC02_RS02925	COG0180	Tryptophanyl-tRNA synthetase
CDHC02_RS02930	COG1295	ribonuclease BN
CDHC02_RS02935	COG1686	Belongs to the peptidase S11 family
CDHC02_RS02950	COG0791	NLP P60 protein
CDHC02_RS02970	COG1473	amidohydrolase
CDHC02_RS02970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CDHC02_RS02995	COG4770	biotin carboxylase activity
CDHC02_RS03000	COG2897	thiosulfate sulfurtransferase activity
CDHC02_RS03005	COG0189	ligase activity
CDHC02_RS03010	COG2755	lipolytic protein G-D-S-L family
CDHC02_RS03010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CDHC02_RS03025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDHC02_RS03040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDHC02_RS03050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDHC02_RS03080	COG0409	Hydrogenase expression formation protein
CDHC02_RS03085	COG0298	carbon dioxide binding
CDHC02_RS03095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CDHC02_RS03100	COG0375	protein maturation
CDHC02_RS03105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDHC02_RS03115	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CDHC02_RS03120	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CDHC02_RS03125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CDHC02_RS03130	COG0375	protein maturation
CDHC02_RS03140	COG0298	carbon dioxide binding
CDHC02_RS03150	COG1316	TRANSCRIPTIONal
CDHC02_RS03160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDHC02_RS03190	COG1482	cell wall glycoprotein biosynthetic process
CDHC02_RS03215	COG0745	RESPONSE REGULATOR receiver
CDHC02_RS03220	COG5002	protein histidine kinase activity
CDHC02_RS03235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CDHC02_RS03270	COG1162	GTPase activity
CDHC02_RS03275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDHC02_RS03280	COG2135	peptidase activity
CDHC02_RS03285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CDHC02_RS03315	COG0513	Belongs to the DEAD box helicase family
CDHC02_RS03345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDHC02_RS03350	COG2816	NAD+ diphosphatase activity
CDHC02_RS03375	COG3480	Lon protease (S16) C-terminal proteolytic domain
CDHC02_RS03440	COG0483	inositol monophosphate 1-phosphatase activity
CDHC02_RS03445	COG0483	inositol monophosphate 1-phosphatase activity
CDHC02_RS03455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CDHC02_RS03460	COG2884	Cell division ATP-binding protein ftsE
CDHC02_RS03465	COG2177	Part of the ABC transporter FtsEX involved in
CDHC02_RS03495	COG1131	(ABC) transporter
CDHC02_RS03510	COG2963	transposase activity
CDHC02_RS03525	COG2226	methyltransferase
CDHC02_RS03530	COG2826	transposase and inactivated derivatives, IS30 family
CDHC02_RS03565	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS03570	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS03605	COG1652	LysM domain
CDHC02_RS03610	COG1278	Cold shock
CDHC02_RS03630	COG2252	PERMEase
CDHC02_RS03635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDHC02_RS03655	COG0372	Belongs to the citrate synthase family
CDHC02_RS03660	COG0545	Peptidyl-prolyl cis-trans isomerase
CDHC02_RS03670	COG0656	L-ascorbic acid biosynthetic process
CDHC02_RS03685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDHC02_RS03695	COG3757	hydrolase, family 25
CDHC02_RS03700	COG0589	response to stress
CDHC02_RS03700	COG0475	glutathione-regulated potassium exporter activity
CDHC02_RS03735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDHC02_RS03755	COG1201	RNA secondary structure unwinding
CDHC02_RS03765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CDHC02_RS03775	COG3304	Inner membrane component domain
CDHC02_RS03840	COG1309	transcriptional regulator
CDHC02_RS03880	COG0745	RESPONSE REGULATOR receiver
CDHC02_RS03885	COG2205	protein histidine kinase activity
CDHC02_RS03890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDHC02_RS03920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CDHC02_RS03950	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CDHC02_RS03955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CDHC02_RS03960	COG3949	Membrane
CDHC02_RS03975	COG0084	hydrolase, TatD family'
CDHC02_RS03980	COG3583	domain protein
CDHC02_RS03995	COG0488	(ABC) transporter
CDHC02_RS04020	COG2326	polyphosphate kinase activity
CDHC02_RS04030	COG0561	phosphatase activity
CDHC02_RS04060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDHC02_RS04070	COG0193	aminoacyl-tRNA hydrolase activity
CDHC02_RS04095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDHC02_RS04115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDHC02_RS04120	COG1132	(ABC) transporter
CDHC02_RS04125	COG1132	(ABC) transporter
CDHC02_RS04150	COG0531	amino acid
CDHC02_RS04155	COG3956	TIGRFAM MazG family protein
CDHC02_RS04215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CDHC02_RS04270	COG0114	fumarate hydratase activity
CDHC02_RS04275	COG1494	fructose-1,6-bisphosphatase
CDHC02_RS04315	COG0733	neurotransmitter:sodium symporter activity
CDHC02_RS04320	COG0012	GTP binding
CDHC02_RS04325	COG2354	Protein conserved in bacteria
CDHC02_RS04350	COG2801	Transposase and inactivated derivatives
CDHC02_RS04355	COG4172	Belongs to the ABC transporter superfamily
CDHC02_RS04365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDHC02_RS04370	COG4166	transmembrane transport
CDHC02_RS04380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDHC02_RS04395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CDHC02_RS04410	COG5640	endopeptidase activity
CDHC02_RS04415	COG1393	Belongs to the ArsC family
CDHC02_RS04430	COG1217	gtp-binding protein TYPA
CDHC02_RS04460	COG0564	pseudouridine synthase activity
CDHC02_RS04475	COG1113	amino acid transport
CDHC02_RS04480	COG2171	N-acyltransferase activity
CDHC02_RS04485	COG1113	amino acid transport
CDHC02_RS04495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDHC02_RS04500	COG1611	Belongs to the LOG family
CDHC02_RS04505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDHC02_RS04510	COG0463	Glycosyl transferase, family 2
CDHC02_RS04530	COG3527	Alpha-acetolactate decarboxylase
CDHC02_RS04535	COG0297	glycogen (starch) synthase activity
CDHC02_RS04550	COG1595	DNA-templated transcription, initiation
CDHC02_RS04575	COG2239	Acts as a magnesium transporter
CDHC02_RS04590	COG0567	Dehydrogenase, E1 component
CDHC02_RS04590	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDHC02_RS04595	COG1132	(ABC) transporter
CDHC02_RS04615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDHC02_RS04645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDHC02_RS04660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CDHC02_RS04670	COG0494	nUDIX hydrolase
CDHC02_RS04695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDHC02_RS04700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDHC02_RS04720	COG2353	YceI-like domain
CDHC02_RS04735	COG1556	Lactate utilization protein
CDHC02_RS04740	COG1139	Iron-sulfur cluster binding protein
CDHC02_RS04745	COG0247	lactate metabolic process
CDHC02_RS04750	COG1620	l-lactate permease
CDHC02_RS04760	COG0019	diaminopimelate decarboxylase activity
CDHC02_RS04765	COG0460	homoserine dehydrogenase
CDHC02_RS04785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CDHC02_RS04785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CDHC02_RS04815	COG0356	it plays a direct role in the translocation of protons across the membrane
CDHC02_RS04820	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDHC02_RS04875	COG1120	ATPase activity
CDHC02_RS04880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDHC02_RS04885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDHC02_RS04890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDHC02_RS04915	COG1119	ATPase activity
CDHC02_RS04935	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CDHC02_RS04945	COG1104	cysteine desulfurase activity
CDHC02_RS04975	COG0281	malic enzyme
CDHC02_RS04990	COG0456	acetyltransferase
CDHC02_RS04990	COG1214	PFAM Peptidase M22, glycoprotease
CDHC02_RS05005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDHC02_RS05010	COG1120	ATPase activity
CDHC02_RS05025	COG0205	6-phosphofructokinase activity
CDHC02_RS05035	COG0667	Aldo Keto reductase
CDHC02_RS05045	COG0583	DNA-binding transcription factor activity
CDHC02_RS05050	COG0435	Glutathione S-transferase
CDHC02_RS05075	COG0028	Belongs to the TPP enzyme family
CDHC02_RS05135	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDHC02_RS05215	COG2824	Alkylphosphonate utilization operon protein PhnA
CDHC02_RS05245	COG0406	alpha-ribazole phosphatase activity
CDHC02_RS05245	COG0494	nUDIX hydrolase
CDHC02_RS05265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CDHC02_RS05270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CDHC02_RS05275	COG1461	Dihydroxyacetone kinase
CDHC02_RS05280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDHC02_RS05290	COG0742	ribosomal rna small subunit methyltransferase
CDHC02_RS05305	COG0765	amino acid transport
CDHC02_RS05335	COG0539	negative regulation of cytoplasmic translation
CDHC02_RS05340	COG3069	C4-dicarboxylate transmembrane transporter activity
CDHC02_RS05345	COG3711	transcriptional antiterminator
CDHC02_RS05375	COG3973	AAA domain
CDHC02_RS05385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDHC02_RS05415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDHC02_RS05445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDHC02_RS05470	COG2835	tetraacyldisaccharide 4'-kinase activity
CDHC02_RS05500	COG0647	UMP catabolic process
CDHC02_RS05530	COG0494	nUDIX hydrolase
CDHC02_RS05535	COG4974	Belongs to the 'phage' integrase family
CDHC02_RS05555	COG3104	oligopeptide transport
CDHC02_RS05560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDHC02_RS05575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CDHC02_RS05590	COG1160	GTP binding
CDHC02_RS05595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CDHC02_RS05600	COG0500	methyltransferase
CDHC02_RS05605	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CDHC02_RS05660	COG1253	flavin adenine dinucleotide binding
CDHC02_RS05665	COG0513	Belongs to the DEAD box helicase family
CDHC02_RS05670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CDHC02_RS05680	COG0598	Magnesium transport protein CorA
CDHC02_RS05740	COG0463	Glycosyl transferase, family 2
CDHC02_RS05745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDHC02_RS05760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDHC02_RS05805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CDHC02_RS05810	COG0805	protein transport
CDHC02_RS05855	COG1362	aminopeptidase activity
CDHC02_RS05875	COG1027	Aspartate ammonia-lyase
CDHC02_RS05880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CDHC02_RS05900	COG0646	methionine synthase
CDHC02_RS05900	COG1410	methionine synthase
CDHC02_RS05935	COG1881	PFAM PEBP family protein
CDHC02_RS05955	COG2897	thiosulfate sulfurtransferase activity
CDHC02_RS06010	COG0791	NLP P60 protein
CDHC02_RS06010	COG3883	PFAM NLP P60 protein
CDHC02_RS06035	COG2848	UPF0210 protein
CDHC02_RS06040	COG0488	(ABC) transporter
CDHC02_RS06045	COG2151	metal-sulfur cluster biosynthetic enzyme
CDHC02_RS06050	COG0822	iron-sulfur transferase activity
CDHC02_RS06055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDHC02_RS06060	COG0396	ATPase activity
CDHC02_RS06065	COG0719	Fe-S assembly protein
CDHC02_RS06105	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDHC02_RS06110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDHC02_RS06130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDHC02_RS06145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDHC02_RS06155	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CDHC02_RS06210	COG0242	peptide deformylase activity
CDHC02_RS06250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDHC02_RS06260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CDHC02_RS06275	COG1090	epimerase
CDHC02_RS06300	COG0006	proline dipeptidase activity
CDHC02_RS06325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDHC02_RS06385	COG1760	l-serine dehydratase
CDHC02_RS06395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDHC02_RS06400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CDHC02_RS06420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDHC02_RS06435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDHC02_RS06440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDHC02_RS06470	COG1946	Acyl-CoA thioesterase
CDHC02_RS06485	COG0156	8-amino-7-oxononanoate synthase activity
CDHC02_RS06495	COG0438	transferase activity, transferring glycosyl groups
CDHC02_RS06500	COG1560	Kdo2-lipid A biosynthetic process
CDHC02_RS06505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CDHC02_RS06520	COG2837	iron assimilation
CDHC02_RS06570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDHC02_RS06575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDHC02_RS06580	COG3253	May function as heme-dependent peroxidase
CDHC02_RS06700	COG0450	alkyl hydroperoxide reductase
CDHC02_RS06715	COG1643	Atp-dependent helicase
CDHC02_RS06735	COG1349	DNA-binding transcription factor activity
CDHC02_RS06740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDHC02_RS06750	COG1105	Belongs to the carbohydrate kinase PfkB family
CDHC02_RS06760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDHC02_RS06765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDHC02_RS06770	COG0431	NADPH-dependent FMN reductase
CDHC02_RS06775	COG2233	PERMEase
CDHC02_RS06780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDHC02_RS06795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDHC02_RS06810	COG1196	nuclear chromosome segregation
CDHC02_RS06845	COG1268	BioY protein
CDHC02_RS06850	COG1122	ATPase activity
CDHC02_RS06855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CDHC02_RS06860	COG1842	Phage shock protein A
CDHC02_RS06865	COG1396	sequence-specific DNA binding
CDHC02_RS06890	COG1674	ftsk spoiiie
CDHC02_RS06900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CDHC02_RS06950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDHC02_RS06955	COG0534	Mate efflux family protein
CDHC02_RS07000	COG3022	response to hydroperoxide
CDHC02_RS07010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDHC02_RS07015	COG0523	cobalamin synthesis protein
CDHC02_RS07020	COG2169	Transcriptional regulator
CDHC02_RS07020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDHC02_RS07070	COG0768	penicillin binding
CDHC02_RS07080	COG0750	zinc metalloprotease
CDHC02_RS07135	COG4974	Belongs to the 'phage' integrase family
CDHC02_RS07165	COG0681	Belongs to the peptidase S26 family
CDHC02_RS07205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CDHC02_RS07265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDHC02_RS07270	COG1929	Belongs to the glycerate kinase type-1 family
CDHC02_RS07290	COG0058	SHG alpha-glucan phosphorylase activity
CDHC02_RS07295	COG0469	pyruvate kinase activity
CDHC02_RS07325	COG0483	inositol monophosphate 1-phosphatase activity
CDHC02_RS07415	COG1739	Uncharacterized protein family UPF0029
CDHC02_RS07420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDHC02_RS07445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDHC02_RS07460	COG0252	asparaginase activity
CDHC02_RS07475	COG3599	regulation of cell shape
CDHC02_RS07485	COG1799	cell septum assembly
CDHC02_RS07490	COG1496	oxidoreductase activity
CDHC02_RS07495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CDHC02_RS07500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CDHC02_RS07535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDHC02_RS07540	COG0768	penicillin binding
CDHC02_RS07580	COG0142	geranyltranstransferase activity
CDHC02_RS07595	COG2815	serine threonine protein kinase
CDHC02_RS07595	COG0515	serine threonine protein kinase
CDHC02_RS07600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CDHC02_RS07615	COG1940	carbohydrate kinase activity
CDHC02_RS07620	COG0438	transferase activity, transferring glycosyl groups
CDHC02_RS07630	COG0791	NLP P60 protein
CDHC02_RS07685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDHC02_RS07695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CDHC02_RS07710	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDHC02_RS07735	COG0174	glutamine synthetase
CDHC02_RS07755	COG2056	Na+-H+ antiporter family
CDHC02_RS07775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CDHC02_RS07800	COG0174	glutamine synthetase
CDHC02_RS07840	COG3323	Protein of unknown function (DUF1653)
CDHC02_RS07840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDHC02_RS07865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDHC02_RS07880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CDHC02_RS07900	COG0596	Alpha beta hydrolase
CDHC02_RS07925	COG2860	membrane
CDHC02_RS07995	COG0423	glycine-tRNA ligase activity
CDHC02_RS08100	COG0339	signal peptide processing
CDHC02_RS08105	COG2272	Belongs to the type-B carboxylesterase lipase family
CDHC02_RS08135	COG1132	(ABC) transporter
CDHC02_RS08145	COG1114	Component of the transport system for branched-chain amino acids
CDHC02_RS08150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDHC02_RS08155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CDHC02_RS08160	COG0747	negative chemotaxis
CDHC02_RS08170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDHC02_RS08175	COG4172	Belongs to the ABC transporter superfamily
CDHC02_RS08185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CDHC02_RS08215	COG0477	Major facilitator Superfamily
CDHC02_RS08270	COG4824	toxin secretion phage lysis holin
CDHC02_RS08340	COG0740	serine-type endopeptidase activity
CDHC02_RS08345	COG4695	Portal protein
CDHC02_RS08350	COG4626	Terminase
CDHC02_RS08350	COG1802	Transcriptional regulator
CDHC02_RS08375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDHC02_RS08430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDHC02_RS08430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDHC02_RS08505	COG1002	Type II restriction enzyme, methylase subunits
CDHC02_RS08540	COG1280	lysine exporter protein (LysE YggA)
CDHC02_RS08565	COG1307	EDD domain protein, DegV family
CDHC02_RS08570	COG0406	alpha-ribazole phosphatase activity
CDHC02_RS08580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CDHC02_RS08615	COG1530	ribonuclease E activity
CDHC02_RS08630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CDHC02_RS08635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDHC02_RS08675	COG2826	transposase and inactivated derivatives, IS30 family
CDHC02_RS08690	COG0285	dihydrofolate synthase activity
CDHC02_RS08715	COG0512	Glutamine amidotransferase of anthranilate synthase
CDHC02_RS08715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDHC02_RS08760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CDHC02_RS08770	COG0668	transmembrane transport
CDHC02_RS08800	COG1276	copper resistance
CDHC02_RS08805	COG1966	Carbon starvation protein
CDHC02_RS08815	COG2801	Transposase and inactivated derivatives
CDHC02_RS08835	COG0604	alcohol dehydrogenase
CDHC02_RS08855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDHC02_RS08860	COG1376	ErfK ybiS ycfS ynhG family protein
CDHC02_RS08905	COG0736	holo-[acyl-carrier-protein] synthase activity
CDHC02_RS08910	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CDHC02_RS08910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDHC02_RS08910	COG3321	synthase
CDHC02_RS08945	COG1234	tRNA 3'-trailer cleavage
CDHC02_RS08960	COG3191	aminopeptidase activity
CDHC02_RS08975	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CDHC02_RS09010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDHC02_RS09020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDHC02_RS09040	COG1233	COG1233 Phytoene dehydrogenase and related
CDHC02_RS09050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CDHC02_RS09100	COG0033	Phosphoglucomutase
CDHC02_RS09115	COG0577	efflux transmembrane transporter activity
CDHC02_RS09115	COG1136	(ABC) transporter
CDHC02_RS09120	COG1136	(ABC) transporter
CDHC02_RS09120	COG0577	efflux transmembrane transporter activity
CDHC02_RS09150	COG2197	response regulator
CDHC02_RS09160	COG1045	serine acetyltransferase
CDHC02_RS09180	COG0371	Dehydrogenase
CDHC02_RS09220	COG1271	oxidase subunit
CDHC02_RS09225	COG1294	oxidase, subunit
CDHC02_RS09230	COG4988	ABC transporter
CDHC02_RS09235	COG1132	(ABC) transporter
CDHC02_RS09270	COG1597	lipid kinase activity
CDHC02_RS09320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDHC02_RS09330	COG0386	Belongs to the glutathione peroxidase family
CDHC02_RS09350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CDHC02_RS09355	COG0436	Aminotransferase
CDHC02_RS09360	COG0569	domain protein
CDHC02_RS09365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CDHC02_RS09370	COG0151	Belongs to the GarS family
CDHC02_RS09375	COG0537	adenosine 5'-monophosphoramidase activity
CDHC02_RS09385	COG2205	protein histidine kinase activity
CDHC02_RS09390	COG0745	RESPONSE REGULATOR receiver
CDHC02_RS09405	COG0477	Major facilitator Superfamily
CDHC02_RS09420	COG0028	Belongs to the TPP enzyme family
CDHC02_RS09455	COG1877	trehalose-phosphatase activity
CDHC02_RS09460	COG1609	Transcriptional regulator
CDHC02_RS09465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDHC02_RS09485	COG1329	Transcriptional regulator
CDHC02_RS09490	COG2847	Copper chaperone PCu(A)C
CDHC02_RS09500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CDHC02_RS09510	COG0288	reversible hydration of carbon dioxide
CDHC02_RS09540	COG2267	carboxylic ester hydrolase activity
CDHC02_RS09550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CDHC02_RS09570	COG1131	(ABC) transporter
CDHC02_RS09585	COG1301	dicarboxylic acid transport
CDHC02_RS09590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDHC02_RS09615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CDHC02_RS09630	COG0302	gtp cyclohydrolase
CDHC02_RS09635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDHC02_RS09640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CDHC02_RS09650	COG2027	D-alanyl-D-alanine carboxypeptidase
CDHC02_RS09655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDHC02_RS09660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDHC02_RS09705	COG2326	polyphosphate kinase activity
CDHC02_RS09725	COG2801	Transposase and inactivated derivatives
CDHC02_RS09740	COG3177	Filamentation induced by cAMP protein fic
CDHC02_RS09750	COG1690	Belongs to the RtcB family
CDHC02_RS09770	COG1902	pentaerythritol trinitrate reductase activity
CDHC02_RS09780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CDHC02_RS09790	COG1196	nuclear chromosome segregation
CDHC02_RS09805	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS09815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDHC02_RS09845	COG0814	amino acid
CDHC02_RS09855	COG2801	Transposase and inactivated derivatives
CDHC02_RS09925	COG0242	peptide deformylase activity
CDHC02_RS09935	COG0708	Exodeoxyribonuclease III
CDHC02_RS09940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDHC02_RS09960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDHC02_RS09965	COG0515	serine threonine protein kinase
CDHC02_RS09975	COG0280	phosphate acetyltransferase
CDHC02_RS09985	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CDHC02_RS09990	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CDHC02_RS10020	COG4129	membrane
CDHC02_RS10030	COG4129	membrane
CDHC02_RS10035	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS10075	COG2610	gluconate transmembrane transporter activity
CDHC02_RS10080	COG2084	Dehydrogenase
CDHC02_RS10105	COG3547	Transposase (IS116 IS110 IS902 family)
CDHC02_RS10110	COG1002	Type II restriction enzyme, methylase subunits
CDHC02_RS10130	COG0191	fructose-bisphosphate aldolase activity
CDHC02_RS10160	COG0765	amino acid transport
CDHC02_RS10180	COG1652	LysM domain
CDHC02_RS10185	COG1131	(ABC) transporter
CDHC02_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
CDHC02_RS10240	COG0789	Transcriptional regulator
CDHC02_RS10260	COG0840	transmembrane signaling receptor activity
CDHC02_RS10275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDHC02_RS10280	COG0601	transmembrane transport
CDHC02_RS10310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDHC02_RS10325	COG2181	nitrate reductase activity
CDHC02_RS10325	COG0247	lactate metabolic process
CDHC02_RS10335	COG1063	alcohol dehydrogenase
CDHC02_RS10385	COG3617	BRO family, N-terminal domain
CDHC02_RS10405	COG1132	(ABC) transporter
CDHC02_RS10410	COG1132	(ABC) transporter
CDHC02_RS10410	COG2375	cellular response to nickel ion
CDHC02_RS10420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDHC02_RS10420	COG3433	isochorismatase activity
CDHC02_RS10420	COG2226	methyltransferase
CDHC02_RS10430	COG0601	transmembrane transport
CDHC02_RS10440	COG1129	ABC transporter
CDHC02_RS10445	COG0477	Major facilitator Superfamily
CDHC02_RS10455	COG2814	Major facilitator Superfamily
CDHC02_RS10475	COG1472	Belongs to the glycosyl hydrolase 3 family
CDHC02_RS10480	COG4981	capsule polysaccharide biosynthetic process
CDHC02_RS10495	COG0500	methyltransferase
CDHC02_RS10540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDHC02_RS10545	COG3321	synthase
CDHC02_RS10545	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CDHC02_RS10545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDHC02_RS10550	COG0318	PFAM AMP-dependent synthetase and ligase
CDHC02_RS10555	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CDHC02_RS10565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CDHC02_RS10565	COG5479	isomerase activity
CDHC02_RS10570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CDHC02_RS10575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CDHC02_RS10580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDHC02_RS10590	COG1216	Glycosyl transferase, family 2
CDHC02_RS10595	COG0671	phosphoesterase, PA-phosphatase related
CDHC02_RS10600	COG1012	belongs to the aldehyde dehydrogenase family
CDHC02_RS10605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CDHC02_RS10635	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CDHC02_RS10660	COG2801	Transposase and inactivated derivatives
CDHC02_RS10680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDHC02_RS10685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CDHC02_RS10690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CDHC02_RS10710	COG2188	Transcriptional regulator
CDHC02_RS10735	COG0077	Prephenate dehydratase
CDHC02_RS10755	COG1316	TRANSCRIPTIONal
CDHC02_RS10760	COG1115	amino acid carrier protein
CDHC02_RS10795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDHC02_RS10815	COG0431	NADPH-dependent FMN reductase
CDHC02_RS10820	COG5650	phosphatidylinositol metabolic process
CDHC02_RS10840	COG2197	response regulator
CDHC02_RS10855	COG2271	Major facilitator Superfamily
CDHC02_RS10865	COG3764	Sortase (surface protein transpeptidase)
CDHC02_RS10870	COG0706	membrane insertase activity
CDHC02_RS10915	COG1131	(ABC) transporter
CDHC02_RS10920	COG2186	Transcriptional regulator
CDHC02_RS10930	COG1842	Phage shock protein A
CDHC02_RS10935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDHC02_RS10950	COG0477	Major facilitator Superfamily
CDHC02_RS10955	COG0305	Participates in initiation and elongation during chromosome replication
CDHC02_RS10985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDHC02_RS11020	COG0586	Pfam SNARE associated Golgi protein
CDHC02_RS11025	COG0783	Belongs to the Dps family
CDHC02_RS11035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDHC02_RS11035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CDHC02_RS11050	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CDHC02_RS11065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDHC02_RS11070	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CDHC02_RS11085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CDHC02_RS11150	COG3177	Filamentation induced by cAMP protein fic
CDHC02_RS11165	COG2032	superoxide dismutase activity
CDHC02_RS11175	COG1136	(ABC) transporter
CDHC02_RS11175	COG0577	efflux transmembrane transporter activity
CDHC02_RS11180	COG0577	efflux transmembrane transporter activity
CDHC02_RS11185	COG4585	Histidine kinase
CDHC02_RS11190	COG2197	response regulator
CDHC02_RS11200	COG1511	domain protein
CDHC02_RS11210	COG1012	belongs to the aldehyde dehydrogenase family
CDHC02_RS11225	COG2376	Dihydroxyacetone kinase
CDHC02_RS11230	COG1461	Dihydroxyacetone kinase
CDHC02_RS11275	COG1116	anion transmembrane transporter activity
CDHC02_RS11310	COG0133	tryptophan synthase activity
CDHC02_RS11315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDHC02_RS11320	COG0512	Glutamine amidotransferase of anthranilate synthase
CDHC02_RS11330	COG0134	indole-3-glycerol-phosphate synthase activity
CDHC02_RS11330	COG0135	phosphoribosylanthranilate isomerase activity
CDHC02_RS11335	COG2832	Protein of unknown function (DUF454)
CDHC02_RS11350	COG0133	tryptophan synthase activity
CDHC02_RS11380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CDHC02_RS11385	COG1678	Uncharacterized ACR, COG1678
CDHC02_RS11390	COG0617	tRNA 3'-terminal CCA addition
CDHC02_RS11410	COG1595	DNA-templated transcription, initiation
CDHC02_RS11425	COG3409	Peptidoglycan-binding domain 1 protein
CDHC02_RS11425	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDHC02_RS11435	COG1192	Involved in chromosome partitioning