locus-tag	class	description
E4651_RS00140	COG0726	polysaccharide deacetylase
E4651_RS00230	COG0287	Prephenate dehydrogenase
E4651_RS00275	COG2409	Drug exporters of the RND superfamily
E4651_RS00280	COG0343	queuine tRNA-ribosyltransferase activity
E4651_RS00290	COG2610	gluconate transmembrane transporter activity
E4651_RS00295	COG3265	gluconokinase activity
E4651_RS00300	COG1063	alcohol dehydrogenase
E4651_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
E4651_RS00325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4651_RS00350	COG1492	cobalamin metabolic process
E4651_RS00355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4651_RS00365	COG0778	Nitroreductase
E4651_RS00370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4651_RS00375	COG2390	Transcriptional regulator
E4651_RS00405	COG2814	Major facilitator Superfamily
E4651_RS00415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4651_RS00425	COG0697	spore germination
E4651_RS00430	COG0527	aspartate kinase activity
E4651_RS00500	COG2271	Major facilitator Superfamily
E4651_RS00505	COG0745	RESPONSE REGULATOR receiver
E4651_RS00530	COG0651	ATP synthesis coupled electron transport
E4651_RS00535	COG1006	Multisubunit Na H antiporter MnhC subunit
E4651_RS00540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4651_RS00540	COG2111	Na H antiporter
E4651_RS00570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4651_RS00585	COG0251	oxidation-reduction process
E4651_RS00590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4651_RS00595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4651_RS00675	COG1205	dead DEAH box helicase
E4651_RS00675	COG1111	helicase
E4651_RS00680	COG1278	Cold shock
E4651_RS00690	COG3842	ATPase activity
E4651_RS00710	COG0702	epimerase
E4651_RS00715	COG1754	DNA topoisomerase type I activity
E4651_RS00715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4651_RS00725	COG1297	OPT oligopeptide transporter protein
E4651_RS00755	COG2856	Zn peptidase
E4651_RS00800	COG3177	Filamentation induced by cAMP protein fic
E4651_RS00835	COG0318	PFAM AMP-dependent synthetase and ligase
E4651_RS00845	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4651_RS00855	COG1088	dTDP-glucose 4,6-dehydratase activity
E4651_RS00865	COG1505	serine-type exopeptidase activity
E4651_RS00875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4651_RS00885	COG3800	Transcriptional regulator
E4651_RS00885	COG1396	sequence-specific DNA binding
E4651_RS00895	COG1053	succinate dehydrogenase
E4651_RS00900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4651_RS00910	COG2733	membrane
E4651_RS00920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4651_RS00930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4651_RS00940	COG1882	Formate acetyltransferase
E4651_RS00965	COG0318	PFAM AMP-dependent synthetase and ligase
E4651_RS00970	COG0318	PFAM AMP-dependent synthetase and ligase
E4651_RS00985	COG5002	protein histidine kinase activity
E4651_RS01010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4651_RS01025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4651_RS01025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4651_RS01050	COG1648	precorrin-2 dehydrogenase activity
E4651_RS01050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4651_RS01055	COG0113	porphobilinogen synthase activity
E4651_RS01090	COG0406	alpha-ribazole phosphatase activity
E4651_RS01100	COG0785	Cytochrome C biogenesis protein
E4651_RS01110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4651_RS01145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4651_RS01150	COG4948	Mandelate Racemase Muconate Lactonizing
E4651_RS01165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4651_RS01165	COG0438	transferase activity, transferring glycosyl groups
E4651_RS01170	COG2226	methyltransferase
E4651_RS01175	COG0039	L-malate dehydrogenase activity
E4651_RS01180	COG0644	oxidoreductase
E4651_RS01185	COG0142	geranyltranstransferase activity
E4651_RS01210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4651_RS01240	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4651_RS01250	COG1121	(ABC) transporter
E4651_RS01255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4651_RS01335	COG4585	Histidine kinase
E4651_RS01340	COG2197	response regulator
E4651_RS01345	COG1131	(ABC) transporter
E4651_RS01360	COG0701	Predicted permease
E4651_RS01405	COG0051	transcription antitermination factor activity, RNA binding
E4651_RS01470	COG1136	(ABC) transporter
E4651_RS01475	COG0577	efflux transmembrane transporter activity
E4651_RS01495	COG0814	amino acid
E4651_RS01500	COG1760	l-serine dehydratase
E4651_RS01505	COG0252	asparaginase activity
E4651_RS01515	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4651_RS01550	COG1140	nitrate reductase beta subunit
E4651_RS01575	COG0746	molybdenum cofactor guanylyltransferase activity
E4651_RS01580	COG0315	cyclic pyranopterin monophosphate synthase activity
E4651_RS01605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4651_RS01615	COG0444	Belongs to the ABC transporter superfamily
E4651_RS01620	COG0601	transmembrane transport
E4651_RS01625	COG0747	negative chemotaxis
E4651_RS01630	COG2186	Transcriptional regulator
E4651_RS01645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4651_RS01720	COG1175	transmembrane transport
E4651_RS01725	COG3833	ABC-type maltose transport systems, permease component
E4651_RS01740	COG3842	ATPase activity
E4651_RS01745	COG0201	protein transport
E4651_RS01805	COG3266	domain, Protein
E4651_RS01815	COG1404	Belongs to the peptidase S8 family
E4651_RS01830	COG1674	ftsk spoiiie
E4651_RS01885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4651_RS01910	COG0456	acetyltransferase
E4651_RS01950	COG0516	GMP reductase activity
E4651_RS01955	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E4651_RS01960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS01965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS01970	COG1120	ATPase activity
E4651_RS02070	COG0668	transmembrane transport
E4651_RS02075	COG2011	ABC-type metal ion transport system permease component
E4651_RS02090	COG1464	Belongs to the NlpA lipoprotein family
E4651_RS02110	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4651_RS02115	COG1121	(ABC) transporter
E4651_RS02170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS02175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4651_RS02185	COG2873	o-acetylhomoserine
E4651_RS02190	COG2838	Isocitrate dehydrogenase
E4651_RS02195	COG2814	Major facilitator Superfamily
E4651_RS02210	COG0180	Tryptophanyl-tRNA synthetase
E4651_RS02215	COG1295	ribonuclease BN
E4651_RS02220	COG1686	Belongs to the peptidase S11 family
E4651_RS02235	COG0791	NLP P60 protein
E4651_RS02255	COG1473	amidohydrolase
E4651_RS02255	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E4651_RS02285	COG2897	thiosulfate sulfurtransferase activity
E4651_RS02290	COG0189	ligase activity
E4651_RS02295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4651_RS02295	COG2755	lipolytic protein G-D-S-L family
E4651_RS02310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4651_RS02335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4651_RS02345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4651_RS02350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4651_RS02350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4651_RS02375	COG0409	Hydrogenase expression formation protein
E4651_RS02380	COG0298	carbon dioxide binding
E4651_RS02390	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4651_RS02395	COG0375	protein maturation
E4651_RS02400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4651_RS02415	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E4651_RS02420	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4651_RS02425	COG0375	protein maturation
E4651_RS02435	COG0298	carbon dioxide binding
E4651_RS02445	COG1316	TRANSCRIPTIONal
E4651_RS02455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4651_RS02485	COG1482	cell wall glycoprotein biosynthetic process
E4651_RS02515	COG0745	RESPONSE REGULATOR receiver
E4651_RS02520	COG5002	protein histidine kinase activity
E4651_RS02535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4651_RS02570	COG1162	GTPase activity
E4651_RS02575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4651_RS02580	COG2135	peptidase activity
E4651_RS02585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4651_RS02620	COG0513	Belongs to the DEAD box helicase family
E4651_RS02645	COG0210	DNA helicase
E4651_RS02650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4651_RS02655	COG2816	NAD+ diphosphatase activity
E4651_RS02680	COG3480	Lon protease (S16) C-terminal proteolytic domain
E4651_RS02760	COG0483	inositol monophosphate 1-phosphatase activity
E4651_RS02765	COG0483	inositol monophosphate 1-phosphatase activity
E4651_RS02775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4651_RS02785	COG2884	Cell division ATP-binding protein ftsE
E4651_RS02790	COG2177	Part of the ABC transporter FtsEX involved in
E4651_RS02820	COG1131	(ABC) transporter
E4651_RS02840	COG2963	transposase activity
E4651_RS02855	COG2226	methyltransferase
E4651_RS02865	COG2826	transposase and inactivated derivatives, IS30 family
E4651_RS02945	COG1652	LysM domain
E4651_RS02950	COG1278	Cold shock
E4651_RS02970	COG2252	PERMEase
E4651_RS02975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4651_RS02995	COG0372	Belongs to the citrate synthase family
E4651_RS03000	COG0545	Peptidyl-prolyl cis-trans isomerase
E4651_RS03010	COG0656	L-ascorbic acid biosynthetic process
E4651_RS03025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4651_RS03035	COG3757	hydrolase, family 25
E4651_RS03040	COG0475	glutathione-regulated potassium exporter activity
E4651_RS03040	COG0589	response to stress
E4651_RS03085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4651_RS03105	COG1201	RNA secondary structure unwinding
E4651_RS03115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4651_RS03125	COG3304	Inner membrane component domain
E4651_RS03190	COG1309	transcriptional regulator
E4651_RS03230	COG0745	RESPONSE REGULATOR receiver
E4651_RS03235	COG2205	protein histidine kinase activity
E4651_RS03240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4651_RS03270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4651_RS03300	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
E4651_RS03305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4651_RS03310	COG3949	Membrane
E4651_RS03325	COG0084	hydrolase, TatD family'
E4651_RS03330	COG3583	domain protein
E4651_RS03345	COG0488	(ABC) transporter
E4651_RS03370	COG2326	polyphosphate kinase activity
E4651_RS03380	COG0561	phosphatase activity
E4651_RS03415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4651_RS03425	COG0193	aminoacyl-tRNA hydrolase activity
E4651_RS03450	COG1523	belongs to the glycosyl hydrolase 13 family
E4651_RS03455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4651_RS03480	COG1132	(ABC) transporter
E4651_RS03485	COG1132	(ABC) transporter
E4651_RS03510	COG0531	amino acid
E4651_RS03515	COG3956	TIGRFAM MazG family protein
E4651_RS03635	COG0114	fumarate hydratase activity
E4651_RS03640	COG1494	fructose-1,6-bisphosphatase
E4651_RS03680	COG0733	neurotransmitter:sodium symporter activity
E4651_RS03685	COG0012	GTP binding
E4651_RS03690	COG2354	Protein conserved in bacteria
E4651_RS03710	COG1122	ATPase activity
E4651_RS03725	COG4166	transmembrane transport
E4651_RS03730	COG0601	transmembrane transport
E4651_RS03735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4651_RS03750	COG1122	ATPase activity
E4651_RS03785	COG5640	endopeptidase activity
E4651_RS03805	COG1217	gtp-binding protein TYPA
E4651_RS03835	COG0564	pseudouridine synthase activity
E4651_RS03850	COG1113	amino acid transport
E4651_RS03855	COG2171	N-acyltransferase activity
E4651_RS03860	COG1113	amino acid transport
E4651_RS03870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4651_RS03875	COG1611	Belongs to the LOG family
E4651_RS03880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4651_RS03885	COG0463	Glycosyl transferase, family 2
E4651_RS03910	COG3527	Alpha-acetolactate decarboxylase
E4651_RS03915	COG0297	glycogen (starch) synthase activity
E4651_RS03930	COG1595	DNA-templated transcription, initiation
E4651_RS03955	COG2239	Acts as a magnesium transporter
E4651_RS03970	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4651_RS03970	COG0567	Dehydrogenase, E1 component
E4651_RS03975	COG1132	(ABC) transporter
E4651_RS03995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4651_RS04000	COG2272	Belongs to the type-B carboxylesterase lipase family
E4651_RS04025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4651_RS04040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4651_RS04050	COG0494	nUDIX hydrolase
E4651_RS04075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4651_RS04080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4651_RS04100	COG2353	YceI-like domain
E4651_RS04120	COG1556	Lactate utilization protein
E4651_RS04125	COG1139	Iron-sulfur cluster binding protein
E4651_RS04130	COG0247	lactate metabolic process
E4651_RS04135	COG1620	l-lactate permease
E4651_RS04145	COG0019	diaminopimelate decarboxylase activity
E4651_RS04150	COG0460	homoserine dehydrogenase
E4651_RS04170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4651_RS04170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4651_RS04200	COG0356	it plays a direct role in the translocation of protons across the membrane
E4651_RS04205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4651_RS04265	COG1120	ATPase activity
E4651_RS04270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS04275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS04280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4651_RS04310	COG1119	ATPase activity
E4651_RS04330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4651_RS04340	COG1104	cysteine desulfurase activity
E4651_RS04370	COG0281	malic enzyme
E4651_RS04385	COG1214	PFAM Peptidase M22, glycoprotease
E4651_RS04385	COG0456	acetyltransferase
E4651_RS04400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS04405	COG1120	ATPase activity
E4651_RS04420	COG0205	6-phosphofructokinase activity
E4651_RS04430	COG0667	Aldo Keto reductase
E4651_RS04440	COG0583	DNA-binding transcription factor activity
E4651_RS04445	COG0435	Glutathione S-transferase
E4651_RS04470	COG0028	Belongs to the TPP enzyme family
E4651_RS04540	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4651_RS04585	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E4651_RS04600	COG2824	Alkylphosphonate utilization operon protein PhnA
E4651_RS04630	COG0406	alpha-ribazole phosphatase activity
E4651_RS04630	COG0494	nUDIX hydrolase
E4651_RS04650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4651_RS04655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4651_RS04660	COG1461	Dihydroxyacetone kinase
E4651_RS04675	COG0742	ribosomal rna small subunit methyltransferase
E4651_RS04695	COG0765	amino acid transport
E4651_RS04725	COG0539	negative regulation of cytoplasmic translation
E4651_RS04730	COG3069	C4-dicarboxylate transmembrane transporter activity
E4651_RS04735	COG3711	transcriptional antiterminator
E4651_RS04765	COG3973	AAA domain
E4651_RS04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4651_RS04835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4651_RS04860	COG2835	tetraacyldisaccharide 4'-kinase activity
E4651_RS04900	COG0647	UMP catabolic process
E4651_RS04930	COG0494	nUDIX hydrolase
E4651_RS04935	COG4974	Belongs to the 'phage' integrase family
E4651_RS04955	COG3104	oligopeptide transport
E4651_RS04960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4651_RS04975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4651_RS04990	COG1160	GTP binding
E4651_RS04995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4651_RS05000	COG0500	methyltransferase
E4651_RS05005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4651_RS05015	COG3012	SEC-C Motif Domain Protein
E4651_RS05065	COG1253	flavin adenine dinucleotide binding
E4651_RS05070	COG0513	Belongs to the DEAD box helicase family
E4651_RS05075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4651_RS05080	COG2050	protein possibly involved in aromatic compounds catabolism
E4651_RS05085	COG0598	Magnesium transport protein CorA
E4651_RS05150	COG0463	Glycosyl transferase, family 2
E4651_RS05155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4651_RS05170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4651_RS05215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4651_RS05220	COG0805	protein transport
E4651_RS05265	COG1362	aminopeptidase activity
E4651_RS05285	COG1027	Aspartate ammonia-lyase
E4651_RS05290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4651_RS05310	COG0646	methionine synthase
E4651_RS05310	COG1410	methionine synthase
E4651_RS05340	COG1881	PFAM PEBP family protein
E4651_RS05370	COG2897	thiosulfate sulfurtransferase activity
E4651_RS05420	COG3883	PFAM NLP P60 protein
E4651_RS05420	COG0791	NLP P60 protein
E4651_RS05445	COG2848	UPF0210 protein
E4651_RS05455	COG0488	(ABC) transporter
E4651_RS05460	COG2151	metal-sulfur cluster biosynthetic enzyme
E4651_RS05465	COG0822	iron-sulfur transferase activity
E4651_RS05470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4651_RS05475	COG0396	ATPase activity
E4651_RS05480	COG0719	Fe-S assembly protein
E4651_RS05520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4651_RS05525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4651_RS05545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4651_RS05560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4651_RS05570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4651_RS05625	COG0242	peptide deformylase activity
E4651_RS05665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4651_RS05675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4651_RS05690	COG1090	epimerase
E4651_RS05715	COG0006	proline dipeptidase activity
E4651_RS05745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4651_RS05805	COG1760	l-serine dehydratase
E4651_RS05815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4651_RS05820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4651_RS05835	COG3328	transposase activity
E4651_RS05850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4651_RS05865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4651_RS05870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4651_RS05900	COG1946	Acyl-CoA thioesterase
E4651_RS05910	COG2801	Transposase and inactivated derivatives
E4651_RS05975	COG0156	8-amino-7-oxononanoate synthase activity
E4651_RS05985	COG0438	transferase activity, transferring glycosyl groups
E4651_RS05990	COG1560	Kdo2-lipid A biosynthetic process
E4651_RS05995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4651_RS06010	COG2837	iron assimilation
E4651_RS06060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4651_RS06065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4651_RS06070	COG3253	May function as heme-dependent peroxidase
E4651_RS06200	COG0450	alkyl hydroperoxide reductase
E4651_RS06235	COG1349	DNA-binding transcription factor activity
E4651_RS06240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4651_RS06250	COG1105	Belongs to the carbohydrate kinase PfkB family
E4651_RS06260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4651_RS06265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4651_RS06275	COG2233	PERMEase
E4651_RS06280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4651_RS06295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4651_RS06310	COG1196	nuclear chromosome segregation
E4651_RS06345	COG1268	BioY protein
E4651_RS06350	COG1122	ATPase activity
E4651_RS06355	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4651_RS06360	COG1842	Phage shock protein A
E4651_RS06365	COG1396	sequence-specific DNA binding
E4651_RS06390	COG1674	ftsk spoiiie
E4651_RS06400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4651_RS06450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4651_RS06455	COG0534	Mate efflux family protein
E4651_RS06500	COG3022	response to hydroperoxide
E4651_RS06510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4651_RS06515	COG0523	cobalamin synthesis protein
E4651_RS06520	COG2169	Transcriptional regulator
E4651_RS06520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4651_RS06570	COG0768	penicillin binding
E4651_RS06580	COG0750	zinc metalloprotease
E4651_RS06635	COG4974	Belongs to the 'phage' integrase family
E4651_RS06665	COG0681	Belongs to the peptidase S26 family
E4651_RS06715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4651_RS06750	COG1115	amino acid carrier protein
E4651_RS06775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4651_RS06780	COG1929	Belongs to the glycerate kinase type-1 family
E4651_RS06800	COG0058	SHG alpha-glucan phosphorylase activity
E4651_RS06805	COG0469	pyruvate kinase activity
E4651_RS06835	COG0483	inositol monophosphate 1-phosphatase activity
E4651_RS06930	COG1739	Uncharacterized protein family UPF0029
E4651_RS06935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4651_RS06960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4651_RS06980	COG0252	asparaginase activity
E4651_RS06995	COG3599	regulation of cell shape
E4651_RS07005	COG1799	cell septum assembly
E4651_RS07010	COG1496	oxidoreductase activity
E4651_RS07015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4651_RS07020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4651_RS07055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4651_RS07060	COG0768	penicillin binding
E4651_RS07100	COG0142	geranyltranstransferase activity
E4651_RS07115	COG2815	serine threonine protein kinase
E4651_RS07115	COG0515	serine threonine protein kinase
E4651_RS07120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E4651_RS07135	COG1940	carbohydrate kinase activity
E4651_RS07140	COG0438	transferase activity, transferring glycosyl groups
E4651_RS07150	COG0791	NLP P60 protein
E4651_RS07205	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4651_RS07215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4651_RS07230	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4651_RS07255	COG0174	glutamine synthetase
E4651_RS07310	COG2801	Transposase and inactivated derivatives
E4651_RS07335	COG2056	Na+-H+ antiporter family
E4651_RS07355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4651_RS07380	COG0174	glutamine synthetase
E4651_RS07435	COG3323	Protein of unknown function (DUF1653)
E4651_RS07435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4651_RS07460	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4651_RS07475	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4651_RS07495	COG0596	Alpha beta hydrolase
E4651_RS07520	COG2860	membrane
E4651_RS07590	COG0423	glycine-tRNA ligase activity
E4651_RS07695	COG2272	Belongs to the type-B carboxylesterase lipase family
E4651_RS07725	COG1132	(ABC) transporter
E4651_RS07735	COG1114	Component of the transport system for branched-chain amino acids
E4651_RS07745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4651_RS07750	COG0747	negative chemotaxis
E4651_RS07760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4651_RS07765	COG4172	Belongs to the ABC transporter superfamily
E4651_RS07775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4651_RS07790	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4651_RS07810	COG0477	Major facilitator Superfamily
E4651_RS07830	COG1002	Type II restriction enzyme, methylase subunits
E4651_RS07890	COG1280	lysine exporter protein (LysE YggA)
E4651_RS07915	COG1307	EDD domain protein, DegV family
E4651_RS07920	COG0406	alpha-ribazole phosphatase activity
E4651_RS07930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4651_RS07965	COG1530	ribonuclease E activity
E4651_RS07980	COG0285	dihydrofolate synthase activity
E4651_RS08005	COG0512	Glutamine amidotransferase of anthranilate synthase
E4651_RS08005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4651_RS08050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4651_RS08090	COG1276	copper resistance
E4651_RS08095	COG1966	Carbon starvation protein
E4651_RS08115	COG0604	alcohol dehydrogenase
E4651_RS08135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4651_RS08140	COG1376	ErfK ybiS ycfS ynhG family protein
E4651_RS08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4651_RS08185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4651_RS08185	COG3321	synthase
E4651_RS08235	COG3191	aminopeptidase activity
E4651_RS08250	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4651_RS08285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4651_RS08295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4651_RS08325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4651_RS08375	COG0033	Phosphoglucomutase
E4651_RS08395	COG0577	efflux transmembrane transporter activity
E4651_RS08395	COG1136	(ABC) transporter
E4651_RS08440	COG2197	response regulator
E4651_RS08450	COG1045	serine acetyltransferase
E4651_RS08525	COG1271	oxidase subunit
E4651_RS08530	COG1294	oxidase, subunit
E4651_RS08535	COG4988	ABC transporter
E4651_RS08540	COG1132	(ABC) transporter
E4651_RS08565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4651_RS08595	COG1597	lipid kinase activity
E4651_RS08650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4651_RS08665	COG0386	Belongs to the glutathione peroxidase family
E4651_RS08685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4651_RS08690	COG0436	Aminotransferase
E4651_RS08695	COG0569	domain protein
E4651_RS08700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4651_RS08705	COG0151	Belongs to the GarS family
E4651_RS08710	COG0537	adenosine 5'-monophosphoramidase activity
E4651_RS08715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4651_RS08720	COG2205	protein histidine kinase activity
E4651_RS08725	COG0745	RESPONSE REGULATOR receiver
E4651_RS08740	COG0477	Major facilitator Superfamily
E4651_RS08805	COG0028	Belongs to the TPP enzyme family
E4651_RS08845	COG1877	trehalose-phosphatase activity
E4651_RS08850	COG1609	Transcriptional regulator
E4651_RS08855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4651_RS08875	COG1329	Transcriptional regulator
E4651_RS08880	COG2847	Copper chaperone PCu(A)C
E4651_RS08890	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4651_RS08900	COG0288	reversible hydration of carbon dioxide
E4651_RS08905	COG1194	a g-specific adenine glycosylase
E4651_RS08935	COG2267	carboxylic ester hydrolase activity
E4651_RS08945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4651_RS08960	COG1131	(ABC) transporter
E4651_RS08980	COG1301	dicarboxylic acid transport
E4651_RS08985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4651_RS09010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4651_RS09025	COG0302	gtp cyclohydrolase
E4651_RS09030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4651_RS09035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4651_RS09045	COG2027	D-alanyl-D-alanine carboxypeptidase
E4651_RS09050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4651_RS09055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4651_RS09080	COG3764	Sortase (surface protein transpeptidase)
E4651_RS09100	COG2326	polyphosphate kinase activity
E4651_RS09135	COG1690	Belongs to the RtcB family
E4651_RS09145	COG1902	pentaerythritol trinitrate reductase activity
E4651_RS09180	COG1196	nuclear chromosome segregation
E4651_RS09195	COG3547	Transposase (IS116 IS110 IS902 family)
E4651_RS09230	COG0814	amino acid
E4651_RS09295	COG0242	peptide deformylase activity
E4651_RS09305	COG0708	Exodeoxyribonuclease III
E4651_RS09310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4651_RS09345	COG0515	serine threonine protein kinase
E4651_RS09355	COG0280	phosphate acetyltransferase
E4651_RS09365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4651_RS09370	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4651_RS09410	COG4129	membrane
E4651_RS09420	COG4129	membrane
E4651_RS09465	COG2610	gluconate transmembrane transporter activity
E4651_RS09470	COG2084	Dehydrogenase
E4651_RS09490	COG3547	Transposase (IS116 IS110 IS902 family)
E4651_RS09535	COG0191	fructose-bisphosphate aldolase activity
E4651_RS09565	COG0765	amino acid transport
E4651_RS09590	COG1652	LysM domain
E4651_RS09595	COG1131	(ABC) transporter
E4651_RS09645	COG1012	belongs to the aldehyde dehydrogenase family
E4651_RS09655	COG0789	Transcriptional regulator
E4651_RS09675	COG0840	transmembrane signaling receptor activity
E4651_RS09685	COG4608	Belongs to the ABC transporter superfamily
E4651_RS09690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4651_RS09695	COG0601	transmembrane transport
E4651_RS09735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4651_RS09750	COG2181	nitrate reductase activity
E4651_RS09750	COG0247	lactate metabolic process
E4651_RS09760	COG1063	alcohol dehydrogenase
E4651_RS09815	COG3617	BRO family, N-terminal domain
E4651_RS09830	COG1132	(ABC) transporter
E4651_RS09835	COG1132	(ABC) transporter
E4651_RS09835	COG2375	cellular response to nickel ion
E4651_RS09845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4651_RS09845	COG3433	isochorismatase activity
E4651_RS09845	COG2226	methyltransferase
E4651_RS09845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4651_RS09845	COG3433	isochorismatase activity
E4651_RS09845	COG2226	methyltransferase
E4651_RS09845	COG2226	methyltransferase
E4651_RS09845	COG3433	isochorismatase activity
E4651_RS09845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4651_RS09855	COG0601	transmembrane transport
E4651_RS09865	COG1129	ABC transporter
E4651_RS09870	COG0477	Major facilitator Superfamily
E4651_RS09880	COG2814	Major facilitator Superfamily
E4651_RS09900	COG1472	Belongs to the glycosyl hydrolase 3 family
E4651_RS09910	COG4981	capsule polysaccharide biosynthetic process
E4651_RS09915	COG2755	lipolytic protein G-D-S-L family
E4651_RS09915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4651_RS09930	COG0438	transferase activity, transferring glycosyl groups
E4651_RS09935	COG0500	methyltransferase
E4651_RS09985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4651_RS09990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4651_RS09990	COG3321	synthase
E4651_RS09990	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4651_RS09995	COG0318	PFAM AMP-dependent synthetase and ligase
E4651_RS10000	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E4651_RS10010	COG5479	isomerase activity
E4651_RS10010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4651_RS10015	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4651_RS10020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4651_RS10025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4651_RS10040	COG0671	phosphoesterase, PA-phosphatase related
E4651_RS10045	COG1012	belongs to the aldehyde dehydrogenase family
E4651_RS10050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4651_RS10075	COG1122	ATPase activity
E4651_RS10115	COG1120	ATPase activity
E4651_RS10125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS10150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4651_RS10155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4651_RS10165	COG0561	phosphatase activity
E4651_RS10175	COG2188	Transcriptional regulator
E4651_RS10220	COG1316	TRANSCRIPTIONal
E4651_RS10230	COG1115	amino acid carrier protein
E4651_RS10270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4651_RS10290	COG0431	NADPH-dependent FMN reductase
E4651_RS10295	COG5650	phosphatidylinositol metabolic process
E4651_RS10315	COG2197	response regulator
E4651_RS10320	COG4585	Histidine kinase
E4651_RS10330	COG2271	Major facilitator Superfamily
E4651_RS10335	COG3764	Sortase (surface protein transpeptidase)
E4651_RS10390	COG1129	ABC transporter
E4651_RS10395	COG2186	Transcriptional regulator
E4651_RS10405	COG1842	Phage shock protein A
E4651_RS10410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4651_RS10425	COG0477	Major facilitator Superfamily
E4651_RS10430	COG0305	Participates in initiation and elongation during chromosome replication
E4651_RS10465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4651_RS10505	COG0586	Pfam SNARE associated Golgi protein
E4651_RS10515	COG0783	Belongs to the Dps family
E4651_RS10525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4651_RS10525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4651_RS10540	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
E4651_RS10560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4651_RS10580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4651_RS10730	COG3177	Filamentation induced by cAMP protein fic
E4651_RS10740	COG2032	superoxide dismutase activity
E4651_RS10755	COG0577	efflux transmembrane transporter activity
E4651_RS10755	COG1136	(ABC) transporter
E4651_RS10770	COG4585	Histidine kinase
E4651_RS10775	COG2197	response regulator
E4651_RS10785	COG1511	domain protein
E4651_RS10795	COG1012	belongs to the aldehyde dehydrogenase family
E4651_RS10835	COG1116	anion transmembrane transporter activity
E4651_RS10870	COG0133	tryptophan synthase activity
E4651_RS10875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4651_RS10880	COG0512	Glutamine amidotransferase of anthranilate synthase
E4651_RS10890	COG0135	phosphoribosylanthranilate isomerase activity
E4651_RS10890	COG0134	indole-3-glycerol-phosphate synthase activity
E4651_RS10895	COG2832	Protein of unknown function (DUF454)
E4651_RS10910	COG0133	tryptophan synthase activity
E4651_RS10940	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4651_RS10945	COG1678	Uncharacterized ACR, COG1678
E4651_RS10950	COG0617	tRNA 3'-terminal CCA addition
E4651_RS10970	COG1595	DNA-templated transcription, initiation
E4651_RS10985	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4651_RS10985	COG3409	Peptidoglycan-binding domain 1 protein
E4651_RS10995	COG1192	Involved in chromosome partitioning
E4651_RS11010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4651_RS11030	COG0592	DNA-directed DNA polymerase activity
E4651_RS11045	COG0187	DNA topoisomerase II activity
E4651_RS11065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4651_RS11090	COG1620	l-lactate permease
E4651_RS11100	COG4988	ABC transporter
E4651_RS11145	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4651_RS11295	COG0352	thiamine-phosphate diphosphorylase activity
E4651_RS11300	COG2022	thiamine diphosphate biosynthetic process
E4651_RS11300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4651_RS11320	COG0352	thiamine-phosphate diphosphorylase activity
E4651_RS11320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4651_RS11320	COG0351	phosphomethylpyrimidine kinase
E4651_RS11360	COG2815	serine threonine protein kinase
E4651_RS11360	COG0515	serine threonine protein kinase
E4651_RS11365	COG0515	serine threonine protein kinase
E4651_RS11370	COG0768	penicillin binding
E4651_RS11390	COG1716	ATPase activity
E4651_RS11390	COG1716	ATPase activity
E4651_RS11490	COG0384	phenazine biosynthesis protein PhzF
E4651_RS11500	COG1131	(ABC) transporter
E4651_RS11505	COG2197	response regulator
E4651_RS11510	COG4585	Histidine kinase
E4651_RS11520	COG1174	glycine betaine transport
E4651_RS11525	COG1174	glycine betaine transport
E4651_RS11530	COG0517	IMP dehydrogenase activity
E4651_RS11530	COG1125	glycine betaine transport
E4651_RS11540	COG1595	DNA-templated transcription, initiation
E4651_RS11560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4651_RS11585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4651_RS11590	COG1120	ATPase activity
E4651_RS11600	COG5646	InterPro IPR014922
E4651_RS11605	COG0415	Belongs to the DNA photolyase family
E4651_RS11680	COG1846	Transcriptional regulator
E4651_RS11685	COG3180	Ammonia monooxygenase
E4651_RS11700	COG1643	Atp-dependent helicase
E4651_RS11760	COG2501	S4 domain
E4651_RS11785	COG3590	peptidase
E4651_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
E4651_RS11830	COG0277	FAD linked oxidase domain protein
E4651_RS11865	COG1216	Glycosyl transferase, family 2
E4651_RS11875	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4651_RS11880	COG1121	(ABC) transporter
E4651_RS11885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4651_RS11890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4651_RS11895	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4651_RS11915	COG0604	alcohol dehydrogenase
E4651_RS11940	COG0471	metal ion transport
E4651_RS11965	COG4974	Belongs to the 'phage' integrase family