locus-tag	class	description
I6J20_RS00045	COG4604	ABC transporter, ATP-binding protein
I6J20_RS00055	COG0310	cobalt ion transport
I6J20_RS00085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J20_RS00100	COG1115	amino acid carrier protein
I6J20_RS00105	COG0033	Phosphoglucomutase
I6J20_RS00125	COG0604	alcohol dehydrogenase
I6J20_RS00140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J20_RS00145	COG2814	Major facilitator Superfamily
I6J20_RS00165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J20_RS00180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J20_RS00185	COG3830	Belongs to the UPF0237 family
I6J20_RS00185	COG0560	Phosphoserine phosphatase
I6J20_RS00200	COG0318	PFAM AMP-dependent synthetase and ligase
I6J20_RS00210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J20_RS00225	COG3191	aminopeptidase activity
I6J20_RS00255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J20_RS00260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J20_RS00270	COG1566	PFAM secretion protein HlyD family protein
I6J20_RS00300	COG3265	gluconokinase activity
I6J20_RS00305	COG4948	Mandelate Racemase Muconate Lactonizing
I6J20_RS00320	COG3250	beta-galactosidase activity
I6J20_RS00325	COG0246	Mannitol dehydrogenase
I6J20_RS00330	COG1904	glucuronate isomerase
I6J20_RS00335	COG2610	gluconate transmembrane transporter activity
I6J20_RS00345	COG1609	Transcriptional regulator
I6J20_RS00365	COG1376	ErfK ybiS ycfS ynhG family protein
I6J20_RS00370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J20_RS00390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J20_RS00395	COG4221	oxidoreductase activity
I6J20_RS00415	COG0363	glucosamine-6-phosphate deaminase activity
I6J20_RS00425	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6J20_RS00430	COG2186	Transcriptional regulator
I6J20_RS00435	COG0747	negative chemotaxis
I6J20_RS00450	COG4608	Belongs to the ABC transporter superfamily
I6J20_RS00455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J20_RS00460	COG0657	acetylesterase activity
I6J20_RS00515	COG2149	membrane
I6J20_RS00520	COG2346	COG2346, Truncated hemoglobins
I6J20_RS00545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J20_RS00550	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J20_RS00560	COG0151	Belongs to the GarS family
I6J20_RS00585	COG0489	protein tyrosine kinase activity
I6J20_RS00590	COG4464	protein tyrosine phosphatase activity
I6J20_RS00620	COG4584	PFAM Integrase catalytic
I6J20_RS00620	COG2390	Transcriptional regulator
I6J20_RS00705	COG0668	transmembrane transport
I6J20_RS00730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J20_RS00735	COG0535	radical SAM domain protein
I6J20_RS00765	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J20_RS00775	COG0740	serine-type endopeptidase activity
I6J20_RS00780	COG0596	Alpha beta hydrolase
I6J20_RS00785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J20_RS00795	COG0039	L-malate dehydrogenase activity
I6J20_RS00810	COG0525	valine-tRNA ligase activity
I6J20_RS00815	COG0285	dihydrofolate synthase activity
I6J20_RS00835	COG0105	UTP biosynthetic process
I6J20_RS00845	COG1530	ribonuclease E activity
I6J20_RS00850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J20_RS00855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J20_RS00860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J20_RS00880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J20_RS00895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J20_RS00900	COG0799	negative regulation of ribosome biogenesis
I6J20_RS00905	COG0406	alpha-ribazole phosphatase activity
I6J20_RS00910	COG1307	EDD domain protein, DegV family
I6J20_RS00915	COG1596	polysaccharide export
I6J20_RS00915	COG1555	photosystem II stabilization
I6J20_RS00950	COG0481	GTPase activity
I6J20_RS00975	COG2391	methyltransferase activity
I6J20_RS00980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J20_RS00985	COG1528	Iron-storage protein
I6J20_RS00990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J20_RS00995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J20_RS01000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J20_RS01005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J20_RS01025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J20_RS01035	COG0747	negative chemotaxis
I6J20_RS01050	COG0798	PFAM Bile acid sodium symporter
I6J20_RS01055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J20_RS01060	COG1114	Component of the transport system for branched-chain amino acids
I6J20_RS01070	COG1132	(ABC) transporter
I6J20_RS01090	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J20_RS01100	COG0366	Alpha amylase catalytic
I6J20_RS01110	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J20_RS01170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J20_RS01185	COG1381	Involved in DNA repair and RecF pathway recombination
I6J20_RS01190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J20_RS01210	COG0423	glycine-tRNA ligase activity
I6J20_RS01230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J20_RS01245	COG2066	Belongs to the glutaminase family
I6J20_RS01265	COG2860	membrane
I6J20_RS01270	COG1823	symporter activity
I6J20_RS01285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J20_RS01290	COG0596	Alpha beta hydrolase
I6J20_RS01295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J20_RS01300	COG1113	amino acid transport
I6J20_RS01330	COG0546	phosphoglycolate phosphatase activity
I6J20_RS01365	COG0577	efflux transmembrane transporter activity
I6J20_RS01370	COG1136	(ABC) transporter
I6J20_RS01385	COG0557	exoribonuclease II activity
I6J20_RS01410	COG0174	glutamine synthetase
I6J20_RS01415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J20_RS01435	COG1129	ABC transporter
I6J20_RS01480	COG1120	ATPase activity
I6J20_RS01495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J20_RS01495	COG1321	iron dependent repressor
I6J20_RS01510	COG0174	glutamine synthetase
I6J20_RS01520	COG2985	domain, Protein
I6J20_RS01520	COG0569	domain protein
I6J20_RS01535	COG0321	lipoyl(octanoyl) transferase activity
I6J20_RS01540	COG0569	domain protein
I6J20_RS01540	COG2985	domain, Protein
I6J20_RS01545	COG0509	glycine decarboxylation via glycine cleavage system
I6J20_RS01550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J20_RS01555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J20_RS01555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J20_RS01560	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J20_RS01575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J20_RS01580	COG3180	Ammonia monooxygenase
I6J20_RS01585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J20_RS01590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J20_RS01625	COG1845	cytochrome c oxidase, subunit III
I6J20_RS01645	COG0791	NLP P60 protein
I6J20_RS01655	COG0438	transferase activity, transferring glycosyl groups
I6J20_RS01660	COG1940	carbohydrate kinase activity
I6J20_RS01675	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J20_RS01680	COG2815	serine threonine protein kinase
I6J20_RS01680	COG0515	serine threonine protein kinase
I6J20_RS01695	COG0142	geranyltranstransferase activity
I6J20_RS01700	COG0456	acetyltransferase
I6J20_RS01720	COG0275	rRNA processing
I6J20_RS01730	COG0768	penicillin binding
I6J20_RS01735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J20_RS01750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J20_RS01760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J20_RS01770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J20_RS01775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J20_RS01780	COG1496	oxidoreductase activity
I6J20_RS01785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J20_RS01790	COG1799	cell septum assembly
I6J20_RS01805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J20_RS01815	COG1113	amino acid transport
I6J20_RS01825	COG0252	asparaginase activity
I6J20_RS01835	COG0488	(ABC) transporter
I6J20_RS01885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J20_RS01900	COG1739	Uncharacterized protein family UPF0029
I6J20_RS01960	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J20_RS01980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J20_RS01985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J20_RS01990	COG0483	inositol monophosphate 1-phosphatase activity
I6J20_RS01995	COG0107	imidazoleglycerol-phosphate synthase activity
I6J20_RS02005	COG0134	indole-3-glycerol-phosphate synthase activity
I6J20_RS02010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J20_RS02015	COG0469	pyruvate kinase activity
I6J20_RS02040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J20_RS02055	COG0571	ribonuclease III activity
I6J20_RS02065	COG2814	Major facilitator Superfamily
I6J20_RS02075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J20_RS02120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J20_RS02125	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J20_RS02140	COG0681	Belongs to the peptidase S26 family
I6J20_RS02145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J20_RS02155	COG0792	nuclease activity
I6J20_RS02170	COG4974	Belongs to the 'phage' integrase family
I6J20_RS02185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J20_RS02215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J20_RS02220	COG0750	zinc metalloprotease
I6J20_RS02225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J20_RS02255	COG2271	Major facilitator Superfamily
I6J20_RS02270	COG0579	oxidoreductase
I6J20_RS02290	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6J20_RS02315	COG2186	Transcriptional regulator
I6J20_RS02345	COG2409	Drug exporters of the RND superfamily
I6J20_RS02350	COG2409	Drug exporters of the RND superfamily
I6J20_RS02360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J20_RS02380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J20_RS02385	COG2977	Belongs to the P-Pant transferase superfamily
I6J20_RS02390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J20_RS02405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J20_RS02440	COG1132	(ABC) transporter
I6J20_RS02445	COG1132	(ABC) transporter
I6J20_RS02455	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J20_RS02465	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6J20_RS02470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J20_RS02475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J20_RS02485	COG1674	ftsk spoiiie
I6J20_RS02505	COG1546	Belongs to the CinA family
I6J20_RS02505	COG1058	Belongs to the CinA family
I6J20_RS02510	COG1396	sequence-specific DNA binding
I6J20_RS02515	COG1842	Phage shock protein A
I6J20_RS02530	COG1122	ATPase activity
I6J20_RS02535	COG1268	BioY protein
I6J20_RS02550	COG2137	regulation of response to DNA damage stimulus
I6J20_RS02555	COG1007	ATP synthesis coupled electron transport
I6J20_RS02570	COG0713	ATP synthesis coupled electron transport
I6J20_RS02575	COG0839	Belongs to the complex I subunit 6 family
I6J20_RS02580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J20_RS02585	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J20_RS02590	COG1034	ATP synthesis coupled electron transport
I6J20_RS02595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J20_RS02605	COG0649	NAD binding
I6J20_RS02610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J20_RS02615	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J20_RS02630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J20_RS02645	COG1196	nuclear chromosome segregation
I6J20_RS02650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J20_RS02655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J20_RS02670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J20_RS02675	COG2233	PERMEase
I6J20_RS02680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J20_RS02685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J20_RS02685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J20_RS02685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J20_RS02700	COG1349	DNA-binding transcription factor activity
I6J20_RS02705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J20_RS02715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J20_RS02720	COG1643	Atp-dependent helicase
I6J20_RS02725	COG0583	DNA-binding transcription factor activity
I6J20_RS02765	COG1321	iron dependent repressor
I6J20_RS02770	COG0477	Major facilitator Superfamily
I6J20_RS02835	COG0756	dUTP diphosphatase activity
I6J20_RS02850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J20_RS02860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J20_RS02875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J20_RS02890	COG3253	May function as heme-dependent peroxidase
I6J20_RS02895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J20_RS02940	COG2837	iron assimilation
I6J20_RS02955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J20_RS02960	COG1560	Kdo2-lipid A biosynthetic process
I6J20_RS02965	COG0438	transferase activity, transferring glycosyl groups
I6J20_RS02975	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J20_RS02985	COG1946	Acyl-CoA thioesterase
I6J20_RS02990	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J20_RS02995	COG0217	transcriptional regulatory protein
I6J20_RS03000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J20_RS03005	COG0632	four-way junction helicase activity
I6J20_RS03015	COG1862	Preprotein translocase
I6J20_RS03020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J20_RS03025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J20_RS03035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J20_RS03040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J20_RS03055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J20_RS03060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J20_RS03065	COG0124	histidyl-tRNA synthetase
I6J20_RS03070	COG1760	l-serine dehydratase
I6J20_RS03100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J20_RS03120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J20_RS03125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J20_RS03130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J20_RS03140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J20_RS03145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J20_RS03155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J20_RS03160	COG0006	proline dipeptidase activity
I6J20_RS03170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J20_RS03175	COG2326	polyphosphate kinase activity
I6J20_RS03195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J20_RS03205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J20_RS03210	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J20_RS03220	COG0194	GDP metabolic process
I6J20_RS03225	COG1758	RNA polymerase activity
I6J20_RS03235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J20_RS03245	COG0242	peptide deformylase activity
I6J20_RS03250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J20_RS03280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J20_RS03290	COG0322	excinuclease ABC activity
I6J20_RS03295	COG1660	Displays ATPase and GTPase activities
I6J20_RS03305	COG1481	regulation of sporulation
I6J20_RS03310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J20_RS03315	COG0126	phosphoglycerate kinase activity
I6J20_RS03320	COG0149	triose-phosphate isomerase activity
I6J20_RS03325	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J20_RS03330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J20_RS03340	COG0363	glucosamine-6-phosphate deaminase activity
I6J20_RS03355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J20_RS03365	COG0109	protoheme IX farnesyltransferase activity
I6J20_RS03370	COG0110	maltose O-acetyltransferase activity
I6J20_RS03390	COG1131	(ABC) transporter
I6J20_RS03415	COG0396	ATPase activity
I6J20_RS03425	COG0822	iron-sulfur transferase activity
I6J20_RS03435	COG2986	histidine ammonia-lyase
I6J20_RS03450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J20_RS03455	COG1228	amidohydrolase
I6J20_RS03480	COG0488	(ABC) transporter
I6J20_RS03485	COG2848	UPF0210 protein
I6J20_RS03490	COG3830	Belongs to the UPF0237 family
I6J20_RS03500	COG0833	amino acid
I6J20_RS03515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J20_RS03525	COG3883	PFAM NLP P60 protein
I6J20_RS03525	COG0791	NLP P60 protein
I6J20_RS03580	COG0662	Cupin 2, conserved barrel domain protein
I6J20_RS03595	COG1881	PFAM PEBP family protein
I6J20_RS03605	COG0167	dihydroorotate dehydrogenase activity
I6J20_RS03620	COG0215	cysteine-tRNA ligase activity
I6J20_RS03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J20_RS03640	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J20_RS03645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J20_RS03650	COG3579	cysteine-type endopeptidase activity
I6J20_RS03660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J20_RS03665	COG1027	Aspartate ammonia-lyase
I6J20_RS03670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J20_RS03680	COG1362	aminopeptidase activity
I6J20_RS03700	COG4122	O-methyltransferase activity
I6J20_RS03725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J20_RS03730	COG0805	protein transport
I6J20_RS03735	COG4581	dead DEAH box helicase
I6J20_RS03815	COG0463	Glycosyl transferase, family 2
I6J20_RS03820	COG3384	dioxygenase
I6J20_RS03850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J20_RS03865	COG1882	Formate acetyltransferase
I6J20_RS03875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J20_RS03880	COG4106	trans-aconitate 2-methyltransferase activity
I6J20_RS03885	COG0814	amino acid
I6J20_RS03890	COG2050	protein possibly involved in aromatic compounds catabolism
I6J20_RS03895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J20_RS03900	COG1253	flavin adenine dinucleotide binding
I6J20_RS03905	COG1253	flavin adenine dinucleotide binding
I6J20_RS03935	COG1716	ATPase activity
I6J20_RS03940	COG0653	protein targeting
I6J20_RS03960	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6J20_RS03965	COG1115	amino acid carrier protein
I6J20_RS03975	COG0438	transferase activity, transferring glycosyl groups
I6J20_RS03990	COG2390	Transcriptional regulator
I6J20_RS03995	COG1160	GTP binding
I6J20_RS04000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J20_RS04005	COG1187	pseudouridine synthase activity
I6J20_RS04015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J20_RS04020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J20_RS04035	COG4974	Belongs to the 'phage' integrase family
I6J20_RS04040	COG0494	nUDIX hydrolase
I6J20_RS04075	COG0647	UMP catabolic process
I6J20_RS04105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J20_RS04130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J20_RS04135	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J20_RS04165	COG1438	arginine binding
I6J20_RS04170	COG2116	formate transmembrane transporter activity
I6J20_RS04175	COG0072	phenylalanine-tRNA ligase activity
I6J20_RS04175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J20_RS04180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J20_RS04200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J20_RS04205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J20_RS04215	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6J20_RS04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J20_RS04245	COG3973	AAA domain
I6J20_RS04260	COG3104	oligopeptide transport
I6J20_RS04270	COG0237	dephospho-CoA kinase activity
I6J20_RS04270	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J20_RS04280	COG0539	negative regulation of cytoplasmic translation
I6J20_RS04285	COG2226	methyltransferase
I6J20_RS04310	COG0477	Major facilitator Superfamily
I6J20_RS04315	COG1120	ATPase activity
I6J20_RS04320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J20_RS04330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J20_RS04345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J20_RS04350	COG0742	ribosomal rna small subunit methyltransferase
I6J20_RS04365	COG1461	Dihydroxyacetone kinase
I6J20_RS04370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J20_RS04375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J20_RS04390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J20_RS04410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J20_RS04445	COG1122	ATPase activity
I6J20_RS04450	COG4721	ABC-type cobalt transport system, permease component
I6J20_RS04460	COG0583	DNA-binding transcription factor activity
I6J20_RS04465	COG2176	DNA-directed DNA polymerase activity
I6J20_RS04475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J20_RS04520	COG3842	ATPase activity
I6J20_RS04525	COG1653	transport
I6J20_RS04530	COG0395	ABC-type sugar transport system, permease component
I6J20_RS04605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J20_RS04605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J20_RS04610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J20_RS04620	COG0028	Belongs to the TPP enzyme family
I6J20_RS04635	COG5650	phosphatidylinositol metabolic process
I6J20_RS04645	COG0435	Glutathione S-transferase
I6J20_RS04650	COG0583	DNA-binding transcription factor activity
I6J20_RS04655	COG1279	arginine transmembrane transporter activity
I6J20_RS04660	COG0667	Aldo Keto reductase
I6J20_RS04665	COG3949	Membrane
I6J20_RS04685	COG0456	acetyltransferase
I6J20_RS04695	COG3949	Membrane
I6J20_RS04700	COG2985	domain, Protein
I6J20_RS04700	COG0569	domain protein
I6J20_RS04710	COG0156	8-amino-7-oxononanoate synthase activity
I6J20_RS04715	COG0205	6-phosphofructokinase activity
I6J20_RS04730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J20_RS04780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J20_RS04785	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J20_RS04790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J20_RS04795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J20_RS04805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J20_RS04820	COG1119	ATPase activity
I6J20_RS04825	COG0366	Alpha amylase catalytic
I6J20_RS04830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J20_RS04850	COG0346	lactoylglutathione lyase activity
I6J20_RS04855	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J20_RS04870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J20_RS04875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J20_RS04890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J20_RS04895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J20_RS04900	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J20_RS04925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J20_RS04930	COG1120	ATPase activity
I6J20_RS04940	COG0829	nickel cation binding
I6J20_RS04945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J20_RS04950	COG0830	nickel cation binding
I6J20_RS04955	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6J20_RS04965	COG0804	urea catabolic process
I6J20_RS04970	COG0832	Belongs to the urease beta subunit family
I6J20_RS04975	COG0831	urea catabolic process
I6J20_RS04985	COG4139	cobalamin transport
I6J20_RS05010	COG0318	PFAM AMP-dependent synthetase and ligase
I6J20_RS05015	COG0584	glycerophosphoryl diester phosphodiesterase
I6J20_RS05015	COG0584	glycerophosphoryl diester phosphodiesterase
I6J20_RS05045	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J20_RS05055	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J20_RS05075	COG0460	homoserine dehydrogenase
I6J20_RS05095	COG0019	diaminopimelate decarboxylase activity
I6J20_RS05100	COG0018	arginyl-trna synthetase
I6J20_RS05105	COG1620	l-lactate permease
I6J20_RS05110	COG0247	lactate metabolic process
I6J20_RS05115	COG1139	Iron-sulfur cluster binding protein
I6J20_RS05120	COG1556	Lactate utilization protein
I6J20_RS05165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J20_RS05170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J20_RS05185	COG0561	phosphatase activity
I6J20_RS05205	COG1113	amino acid transport
I6J20_RS05210	COG0494	nUDIX hydrolase
I6J20_RS05235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J20_RS05245	COG1132	(ABC) transporter
I6J20_RS05250	COG0567	Dehydrogenase, E1 component
I6J20_RS05250	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J20_RS05255	COG0596	Alpha beta hydrolase
I6J20_RS05260	COG0193	aminoacyl-tRNA hydrolase activity
I6J20_RS05270	COG0598	Magnesium transport protein CorA
I6J20_RS05295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J20_RS05300	COG5662	AntiSigma factor
I6J20_RS05315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J20_RS05320	COG0297	glycogen (starch) synthase activity
I6J20_RS05330	COG2390	Transcriptional regulator
I6J20_RS05330	COG4584	PFAM Integrase catalytic
I6J20_RS05360	COG1611	Belongs to the LOG family
I6J20_RS05365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J20_RS05375	COG1113	amino acid transport
I6J20_RS05380	COG2171	N-acyltransferase activity
I6J20_RS05385	COG1113	amino acid transport
I6J20_RS05415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J20_RS05420	COG0747	negative chemotaxis
I6J20_RS05425	COG1217	gtp-binding protein TYPA
I6J20_RS05440	COG2354	Protein conserved in bacteria
I6J20_RS05445	COG0428	transporter
I6J20_RS05485	COG0012	GTP binding
I6J20_RS05495	COG0628	permease
I6J20_RS05500	COG1322	Protein conserved in bacteria
I6J20_RS05515	COG1570	exodeoxyribonuclease VII activity
I6J20_RS05530	COG1494	fructose-1,6-bisphosphatase
I6J20_RS05535	COG0114	fumarate hydratase activity
I6J20_RS05545	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J20_RS05550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J20_RS05555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J20_RS05600	COG1072	(Pantothenic acid kinase))
I6J20_RS05620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J20_RS05675	COG3956	TIGRFAM MazG family protein
I6J20_RS05695	COG2132	Multicopper oxidase
I6J20_RS05700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J20_RS05705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J20_RS05715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J20_RS05720	COG1301	dicarboxylic acid transport
I6J20_RS05725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J20_RS05750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J20_RS05755	COG0488	(ABC) transporter
I6J20_RS05760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J20_RS05770	COG3583	domain protein
I6J20_RS05775	COG0084	hydrolase, TatD family'
I6J20_RS05790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J20_RS05800	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6J20_RS05810	COG2259	Doxx family
I6J20_RS05835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J20_RS05860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J20_RS05865	COG2205	protein histidine kinase activity
I6J20_RS05870	COG0745	RESPONSE REGULATOR receiver
I6J20_RS05880	COG0254	rRNA binding
I6J20_RS05890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J20_RS05895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J20_RS05915	COG2132	Multicopper oxidase
I6J20_RS05920	COG0138	bifunctional purine biosynthesis protein purh
I6J20_RS05935	COG0739	heme binding
I6J20_RS05945	COG1605	Chorismate mutase
I6J20_RS05955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J20_RS05960	COG0601	transmembrane transport
I6J20_RS05965	COG4166	transmembrane transport
I6J20_RS05970	COG0157	Belongs to the NadC ModD family
I6J20_RS05995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J20_RS06000	COG1201	RNA secondary structure unwinding
I6J20_RS06005	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6J20_RS06020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J20_RS06040	COG3415	Transposase
I6J20_RS06040	COG2801	Transposase and inactivated derivatives
I6J20_RS06045	COG3757	hydrolase, family 25
I6J20_RS06050	COG0189	ligase activity
I6J20_RS06055	COG0475	glutathione-regulated potassium exporter activity
I6J20_RS06060	COG1024	Enoyl-CoA hydratase
I6J20_RS06065	COG0656	L-ascorbic acid biosynthetic process
I6J20_RS06075	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J20_RS06080	COG0372	Belongs to the citrate synthase family
I6J20_RS06100	COG3104	oligopeptide transport
I6J20_RS06105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J20_RS06110	COG2252	PERMEase
I6J20_RS06135	COG1652	LysM domain
I6J20_RS06165	COG2217	Heavy metal translocating P-type atpase
I6J20_RS06170	COG1937	Protein conserved in bacteria
I6J20_RS06200	COG2233	PERMEase
I6J20_RS06205	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J20_RS06205	COG0824	Thioesterase
I6J20_RS06235	COG2177	Part of the ABC transporter FtsEX involved in
I6J20_RS06240	COG2884	Cell division ATP-binding protein ftsE
I6J20_RS06280	COG0483	inositol monophosphate 1-phosphatase activity
I6J20_RS06285	COG0483	inositol monophosphate 1-phosphatase activity
I6J20_RS06325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J20_RS06330	COG1335	isochorismatase
I6J20_RS06360	COG2072	flavoprotein involved in K transport
I6J20_RS06390	COG1177	transmembrane transport
I6J20_RS06440	COG0477	Major facilitator Superfamily
I6J20_RS06445	COG1615	UPF0182 protein
I6J20_RS06460	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J20_RS06485	COG2816	NAD+ diphosphatase activity
I6J20_RS06490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J20_RS06490	COG0475	glutathione-regulated potassium exporter activity
I6J20_RS06525	COG0513	Belongs to the DEAD box helicase family
I6J20_RS06540	COG1597	lipid kinase activity
I6J20_RS06570	COG2135	peptidase activity
I6J20_RS06575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J20_RS06580	COG1162	GTPase activity
I6J20_RS06585	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J20_RS06590	COG1121	(ABC) transporter
I6J20_RS06595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J20_RS06610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J20_RS06615	COG0653	protein targeting
I6J20_RS06620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J20_RS06635	COG5002	protein histidine kinase activity
I6J20_RS06635	COG5000	phosphorelay sensor kinase activity
I6J20_RS06640	COG0745	RESPONSE REGULATOR receiver
I6J20_RS06660	COG1482	cell wall glycoprotein biosynthetic process
I6J20_RS06670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J20_RS06700	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J20_RS06705	COG1316	TRANSCRIPTIONal
I6J20_RS06715	COG3842	ATPase activity
I6J20_RS06765	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6J20_RS06765	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6J20_RS06770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J20_RS06780	COG1297	OPT oligopeptide transporter protein
I6J20_RS06785	COG0424	maF-like protein
I6J20_RS06795	COG4085	toxin activity
I6J20_RS06795	COG0737	Belongs to the 5'-nucleotidase family
I6J20_RS06795	COG1525	nuclease
I6J20_RS06800	COG2897	thiosulfate sulfurtransferase activity
I6J20_RS06805	COG4770	biotin carboxylase activity
I6J20_RS06810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6J20_RS06820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J20_RS06820	COG1473	amidohydrolase
I6J20_RS06825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J20_RS06855	COG1686	Belongs to the peptidase S11 family
I6J20_RS06870	COG1295	ribonuclease BN
I6J20_RS06875	COG0180	Tryptophanyl-tRNA synthetase
I6J20_RS06880	COG3527	Alpha-acetolactate decarboxylase
I6J20_RS06890	COG2838	Isocitrate dehydrogenase
I6J20_RS06895	COG2814	Major facilitator Superfamily
I6J20_RS06900	COG2873	o-acetylhomoserine
I6J20_RS06905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J20_RS06910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J20_RS06935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J20_RS06960	COG0587	DNA-directed DNA polymerase activity
I6J20_RS06965	COG1464	Belongs to the NlpA lipoprotein family
I6J20_RS06975	COG2011	ABC-type metal ion transport system permease component
I6J20_RS07010	COG0076	glutamate decarboxylase activity
I6J20_RS07030	COG0516	GMP reductase activity
I6J20_RS07060	COG0459	protein refolding
I6J20_RS07065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J20_RS07105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J20_RS07120	COG0456	acetyltransferase
I6J20_RS07160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J20_RS07165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J20_RS07190	COG1674	ftsk spoiiie
I6J20_RS07200	COG1404	Belongs to the peptidase S8 family
I6J20_RS07215	COG0101	tRNA pseudouridine synthase activity
I6J20_RS07235	COG0203	ribosomal protein L17
I6J20_RS07245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J20_RS07250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J20_RS07275	COG0514	ATP-dependent DNA helicase (RecQ)
I6J20_RS07290	COG3022	response to hydroperoxide
I6J20_RS07295	COG0563	adenylate kinase activity
I6J20_RS07300	COG0201	protein transport
I6J20_RS07305	COG0200	Binds to the 23S rRNA
I6J20_RS07310	COG1841	ribosomal large subunit assembly
I6J20_RS07320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J20_RS07345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J20_RS07380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J20_RS07385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J20_RS07420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J20_RS07440	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J20_RS07445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J20_RS07455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J20_RS07465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J20_RS07470	COG0089	rRNA binding
I6J20_RS07485	COG0051	transcription antitermination factor activity, RNA binding
I6J20_RS07490	COG1302	Protein conserved in bacteria
I6J20_RS07540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J20_RS07560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J20_RS07575	COG0222	ribosome binding
I6J20_RS07580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J20_RS07595	COG0081	regulation of translation
I6J20_RS07600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J20_RS07645	COG0142	geranyltranstransferase activity
I6J20_RS07650	COG0644	oxidoreductase
I6J20_RS07655	COG2226	methyltransferase
I6J20_RS07660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J20_RS07660	COG0438	transferase activity, transferring glycosyl groups
I6J20_RS07670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J20_RS07675	COG4948	Mandelate Racemase Muconate Lactonizing
I6J20_RS07685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J20_RS07750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J20_RS07760	COG0785	Cytochrome C biogenesis protein
I6J20_RS07770	COG0406	alpha-ribazole phosphatase activity
I6J20_RS07780	COG0443	Heat shock 70 kDa protein
I6J20_RS07795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J20_RS07815	COG0113	porphobilinogen synthase activity
I6J20_RS07820	COG1648	precorrin-2 dehydrogenase activity
I6J20_RS07820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J20_RS07830	COG0181	hydroxymethylbilane synthase activity
I6J20_RS07860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J20_RS07885	COG5002	protein histidine kinase activity
I6J20_RS07890	COG0588	phosphoglycerate mutase activity
I6J20_RS07895	COG0438	transferase activity, transferring glycosyl groups
I6J20_RS07900	COG0318	PFAM AMP-dependent synthetase and ligase
I6J20_RS07905	COG0039	L-malate dehydrogenase activity
I6J20_RS07910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J20_RS07925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J20_RS07945	COG2733	membrane
I6J20_RS07955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J20_RS07960	COG1053	succinate dehydrogenase
I6J20_RS07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J20_RS08005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J20_RS08005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J20_RS08015	COG2814	Major facilitator Superfamily
I6J20_RS08075	COG0470	DNA polymerase III
I6J20_RS08095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J20_RS08095	COG1754	DNA topoisomerase type I activity
I6J20_RS08100	COG1278	Cold shock
I6J20_RS08105	COG1205	dead DEAH box helicase
I6J20_RS08105	COG1111	helicase
I6J20_RS08175	COG0494	nUDIX hydrolase
I6J20_RS08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J20_RS08190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J20_RS08260	COG2111	Na H antiporter
I6J20_RS08260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J20_RS08270	COG0651	ATP synthesis coupled electron transport
I6J20_RS08325	COG0527	aspartate kinase activity
I6J20_RS08330	COG0697	spore germination
I6J20_RS08350	COG0189	ligase activity
I6J20_RS08350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J20_RS08355	COG3442	glutamine amidotransferase
I6J20_RS08365	COG1136	(ABC) transporter
I6J20_RS08375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J20_RS08395	COG0765	amino acid transport
I6J20_RS08400	COG0765	amino acid transport
I6J20_RS08405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J20_RS08410	COG1126	abc transporter atp-binding protein
I6J20_RS08415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J20_RS08425	COG2197	response regulator
I6J20_RS08435	COG1136	(ABC) transporter
I6J20_RS08465	COG1968	undecaprenyl-diphosphatase activity
I6J20_RS08490	COG1132	(ABC) transporter
I6J20_RS08495	COG5265	(ABC) transporter
I6J20_RS08535	COG0540	Belongs to the ATCase OTCase family
I6J20_RS08545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J20_RS08555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J20_RS08570	COG0343	queuine tRNA-ribosyltransferase activity
I6J20_RS08575	COG2409	Drug exporters of the RND superfamily
I6J20_RS08585	COG3237	CsbD-like
I6J20_RS08595	COG0287	Prephenate dehydrogenase
I6J20_RS08630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J20_RS08640	COG0604	alcohol dehydrogenase
I6J20_RS08665	COG0351	phosphomethylpyrimidine kinase
I6J20_RS08665	COG0352	thiamine-phosphate diphosphorylase activity
I6J20_RS08665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J20_RS08700	COG1216	Glycosyl transferase, family 2
I6J20_RS08725	COG0277	FAD linked oxidase domain protein
I6J20_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
I6J20_RS08790	COG3409	Peptidoglycan-binding domain 1 protein
I6J20_RS08790	COG3757	hydrolase, family 25
I6J20_RS08805	COG3590	peptidase
I6J20_RS08835	COG2501	S4 domain
I6J20_RS08845	COG1280	lysine exporter protein (LysE YggA)
I6J20_RS08860	COG2818	Glycosylase
I6J20_RS08870	COG0577	efflux transmembrane transporter activity
I6J20_RS08870	COG1136	(ABC) transporter
I6J20_RS08880	COG1643	Atp-dependent helicase
I6J20_RS08910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J20_RS08920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J20_RS08945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J20_RS08980	COG1518	maintenance of DNA repeat elements
I6J20_RS08990	COG0676	glucose-6-phosphate 1-epimerase activity
I6J20_RS09000	COG2966	Psort location CytoplasmicMembrane, score
I6J20_RS09005	COG0672	)-iron permease
I6J20_RS09015	COG2837	iron assimilation
I6J20_RS09025	COG1136	(ABC) transporter
I6J20_RS09050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J20_RS09055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J20_RS09065	COG2217	Heavy metal translocating P-type atpase
I6J20_RS09075	COG2205	protein histidine kinase activity
I6J20_RS09080	COG0745	RESPONSE REGULATOR receiver
I6J20_RS09100	COG2132	Multicopper oxidase
I6J20_RS09110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J20_RS09135	COG2072	flavoprotein involved in K transport
I6J20_RS09155	COG1716	ATPase activity
I6J20_RS09155	COG1716	ATPase activity
I6J20_RS09175	COG0768	penicillin binding
I6J20_RS09180	COG0515	serine threonine protein kinase
I6J20_RS09185	COG2815	serine threonine protein kinase
I6J20_RS09185	COG0515	serine threonine protein kinase
I6J20_RS09205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J20_RS09230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J20_RS09235	COG0813	purine-nucleoside phosphorylase activity
I6J20_RS09250	COG0351	phosphomethylpyrimidine kinase
I6J20_RS09255	COG0193	aminoacyl-tRNA hydrolase activity
I6J20_RS09280	COG2186	Transcriptional regulator
I6J20_RS09290	COG2084	Dehydrogenase
I6J20_RS09295	COG2610	gluconate transmembrane transporter activity
I6J20_RS09315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J20_RS09320	COG2837	iron assimilation
I6J20_RS09340	COG1621	beta-fructofuranosidase activity
I6J20_RS09355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J20_RS09360	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J20_RS09375	COG1070	Carbohydrate kinase
I6J20_RS09390	COG1940	carbohydrate kinase activity
I6J20_RS09415	COG0246	Mannitol dehydrogenase
I6J20_RS09420	COG1070	Carbohydrate kinase
I6J20_RS09450	COG3971	2-oxopent-4-enoate hydratase activity
I6J20_RS09460	COG1012	belongs to the aldehyde dehydrogenase family
I6J20_RS09465	COG1802	Transcriptional regulator
I6J20_RS09475	COG0477	Major facilitator Superfamily
I6J20_RS09495	COG1070	Carbohydrate kinase
I6J20_RS09515	COG2814	Major facilitator Superfamily
I6J20_RS09520	COG1979	alcohol dehydrogenase
I6J20_RS09540	COG0135	phosphoribosylanthranilate isomerase activity
I6J20_RS09545	COG1122	ATPase activity
I6J20_RS09565	COG1609	Transcriptional regulator
I6J20_RS09575	COG1609	Transcriptional regulator
I6J20_RS09650	COG2610	gluconate transmembrane transporter activity
I6J20_RS09655	COG3048	D-serine ammonia-lyase activity
I6J20_RS09660	COG2964	Protein conserved in bacteria
I6J20_RS09665	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J20_RS09665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J20_RS09675	COG0732	type I restriction modification DNA specificity domain
I6J20_RS09680	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J20_RS09695	COG1511	domain protein
I6J20_RS09705	COG1473	amidohydrolase
I6J20_RS09725	COG0328	RNA-DNA hybrid ribonuclease activity
I6J20_RS09740	COG1785	Belongs to the alkaline phosphatase family
I6J20_RS09750	COG0247	lactate metabolic process
I6J20_RS09750	COG0277	FAD linked oxidase domain protein
I6J20_RS09765	COG0243	molybdopterin cofactor binding
I6J20_RS09770	COG5640	endopeptidase activity
I6J20_RS09870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J20_RS09895	COG1263	PTS System
I6J20_RS09895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J20_RS09895	COG2190	(PTS) system
I6J20_RS09900	COG3711	transcriptional antiterminator
I6J20_RS09920	COG1120	ATPase activity
I6J20_RS09925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J20_RS09930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J20_RS09965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J20_RS09995	COG0187	DNA topoisomerase II activity
I6J20_RS10000	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J20_RS10005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J20_RS10010	COG0592	DNA-directed DNA polymerase activity
I6J20_RS10020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J20_RS10025	COG0594	ribonuclease P activity
I6J20_RS10030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J20_RS10040	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J20_RS10045	COG1192	Involved in chromosome partitioning
I6J20_RS10060	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J20_RS10060	COG3409	Peptidoglycan-binding domain 1 protein
I6J20_RS10065	COG3118	belongs to the thioredoxin family
I6J20_RS10095	COG0617	tRNA 3'-terminal CCA addition
I6J20_RS10110	COG1687	branched-chain amino acid
I6J20_RS10130	COG0159	tryptophan synthase activity
I6J20_RS10140	COG0135	phosphoribosylanthranilate isomerase activity
I6J20_RS10140	COG0134	indole-3-glycerol-phosphate synthase activity
I6J20_RS10145	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J20_RS10150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J20_RS10165	COG0495	leucyl-tRNA aminoacylation
I6J20_RS10190	COG4868	Belongs to the UPF0371 family
I6J20_RS10215	COG4221	oxidoreductase activity
I6J20_RS10225	COG1846	Transcriptional regulator
I6J20_RS10235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J20_RS10260	COG0629	single-stranded DNA binding
I6J20_RS10265	COG0359	binds to the 23S rRNA
I6J20_RS10270	COG0305	Participates in initiation and elongation during chromosome replication
I6J20_RS10275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J20_RS10280	COG1842	Phage shock protein A
I6J20_RS10330	COG0577	efflux transmembrane transporter activity
I6J20_RS10330	COG1136	(ABC) transporter
I6J20_RS10335	COG1136	(ABC) transporter
I6J20_RS10335	COG0577	efflux transmembrane transporter activity
I6J20_RS10340	COG0564	pseudouridine synthase activity
I6J20_RS10390	COG2197	response regulator
I6J20_RS10430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J20_RS10530	COG0077	Prephenate dehydratase
I6J20_RS10535	COG0154	amidase activity
I6J20_RS10540	COG1316	TRANSCRIPTIONal
I6J20_RS10575	COG2188	Transcriptional regulator
I6J20_RS10580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J20_RS10625	COG2011	ABC-type metal ion transport system permease component
I6J20_RS10685	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J20_RS10700	COG2011	ABC-type metal ion transport system permease component
I6J20_RS10705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J20_RS10725	COG1854	S-ribosylhomocysteine lyase activity
I6J20_RS10740	COG1131	(ABC) transporter
I6J20_RS10755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J20_RS10760	COG0084	hydrolase, TatD family'
I6J20_RS10790	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J20_RS10860	COG4584	PFAM Integrase catalytic
I6J20_RS10860	COG2390	Transcriptional regulator
I6J20_RS10880	COG1216	Glycosyl transferase, family 2
I6J20_RS10885	COG0671	phosphoesterase, PA-phosphatase related
I6J20_RS10890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J20_RS10895	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J20_RS10915	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J20_RS10915	COG5479	isomerase activity
I6J20_RS10925	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6J20_RS10935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J20_RS10935	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J20_RS10935	COG3321	synthase
I6J20_RS10940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J20_RS11010	COG2814	Major facilitator Superfamily
I6J20_RS11030	COG3077	Addiction module antitoxin, RelB DinJ family
I6J20_RS11060	COG0500	methyltransferase
I6J20_RS11120	COG4981	capsule polysaccharide biosynthetic process
I6J20_RS11120	COG4981	capsule polysaccharide biosynthetic process
I6J20_RS11130	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J20_RS11135	COG2720	vancomycin resistance protein
I6J20_RS11155	COG3158	transport of potassium into the cell
I6J20_RS11165	COG0436	Aminotransferase
I6J20_RS11235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J20_RS11235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J20_RS11240	COG0717	Belongs to the dCTP deaminase family
I6J20_RS11245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J20_RS11290	COG0247	lactate metabolic process
I6J20_RS11290	COG2181	nitrate reductase activity
I6J20_RS11300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J20_RS11305	COG1121	(ABC) transporter
I6J20_RS11325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J20_RS11350	COG0730	response to heat
I6J20_RS11360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J20_RS11375	COG0628	permease
I6J20_RS11380	COG3268	Saccharopine dehydrogenase
I6J20_RS11390	COG0443	Heat shock 70 kDa protein
I6J20_RS11395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J20_RS11400	COG0484	heat shock protein binding
I6J20_RS11405	COG0789	Transcriptional regulator
I6J20_RS11420	COG2197	response regulator
I6J20_RS11440	COG0542	response to heat
I6J20_RS11495	COG0191	fructose-bisphosphate aldolase activity
I6J20_RS11500	COG4129	membrane
I6J20_RS11510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J20_RS11525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6J20_RS11530	COG2153	protein acetylation
I6J20_RS11545	COG0280	phosphate acetyltransferase
I6J20_RS11575	COG0515	serine threonine protein kinase
I6J20_RS11580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J20_RS11610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J20_RS11620	COG0833	amino acid
I6J20_RS11655	COG0531	amino acid
I6J20_RS11660	COG1012	belongs to the aldehyde dehydrogenase family
I6J20_RS11670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J20_RS11680	COG0242	peptide deformylase activity
I6J20_RS11705	COG1473	amidohydrolase
I6J20_RS11710	COG1320	monovalent cation:proton antiporter activity
I6J20_RS11725	COG0651	ATP synthesis coupled electron transport
I6J20_RS11730	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J20_RS11735	COG2111	Na H antiporter
I6J20_RS11735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J20_RS11750	COG0459	protein refolding
I6J20_RS11765	COG2326	polyphosphate kinase activity
I6J20_RS11770	COG1846	Transcriptional regulator
I6J20_RS11775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J20_RS11780	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J20_RS11785	COG0037	tRNA processing
I6J20_RS11790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J20_RS11795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J20_RS11800	COG0302	gtp cyclohydrolase
I6J20_RS11805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J20_RS11810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J20_RS11810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J20_RS11825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J20_RS11850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J20_RS11860	COG1396	sequence-specific DNA binding
I6J20_RS11865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J20_RS11885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J20_RS11915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J20_RS11975	COG0450	alkyl hydroperoxide reductase
I6J20_RS11995	COG3617	BRO family, N-terminal domain
I6J20_RS12020	COG1725	Transcriptional regulator
I6J20_RS12025	COG0842	Transport permease protein
I6J20_RS12025	COG1129	ABC transporter
I6J20_RS12040	COG1002	Type II restriction enzyme, methylase subunits
I6J20_RS12045	COG4942	peptidase
I6J20_RS12055	COG0419	ATPase involved in DNA repair
I6J20_RS12075	COG1194	a g-specific adenine glycosylase
I6J20_RS12095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J20_RS12110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J20_RS12120	COG0215	cysteine-tRNA ligase activity
I6J20_RS12125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J20_RS12135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J20_RS12140	COG1121	(ABC) transporter
I6J20_RS12150	COG1609	Transcriptional regulator
I6J20_RS12155	COG1877	trehalose-phosphatase activity
I6J20_RS12190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J20_RS12195	COG1120	ATPase activity
I6J20_RS12200	COG0028	Belongs to the TPP enzyme family
I6J20_RS12205	COG0745	RESPONSE REGULATOR receiver
I6J20_RS12210	COG5002	protein histidine kinase activity
I6J20_RS12220	COG0537	adenosine 5'-monophosphoramidase activity
I6J20_RS12225	COG0151	Belongs to the GarS family
I6J20_RS12230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J20_RS12265	COG3842	ATPase activity
I6J20_RS12310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J20_RS12315	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J20_RS12340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J20_RS12350	COG0354	folic acid binding
I6J20_RS12370	COG0456	acetyltransferase
I6J20_RS12390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J20_RS12445	COG1045	serine acetyltransferase
I6J20_RS12460	COG2197	response regulator
I6J20_RS12475	COG1970	mechanosensitive ion channel activity
I6J20_RS12480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J20_RS12490	COG0409	Hydrogenase expression formation protein
I6J20_RS12505	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6J20_RS12510	COG0375	protein maturation
I6J20_RS12535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J20_RS12540	COG0375	protein maturation
I6J20_RS12545	COG3259	Nickel-dependent hydrogenase