locus-tag	class	description
NCgl0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NCgl0002	COG0592	DNA-directed DNA polymerase activity
NCgl0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NCgl0005	COG0187	DNA topoisomerase II activity
NCgl0014	COG2855	membrane
NCgl0015	COG0583	DNA-binding transcription factor activity
NCgl0018	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NCgl0018	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NCgl0023	COG1764	response to oxidative stress
NCgl0026	COG0803	Belongs to the bacterial solute-binding protein 9 family
NCgl0027	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NCgl0028	COG1120	ATPase activity
NCgl0030	COG1172	Belongs to the binding-protein-dependent transport system permease family
NCgl0031	COG1129	ABC transporter
NCgl0036	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl0037	COG1120	ATPase activity
NCgl0040	COG2815	serine threonine protein kinase
NCgl0040	COG0515	serine threonine protein kinase
NCgl0041	COG0515	serine threonine protein kinase
NCgl0042	COG0768	penicillin binding
NCgl0046	COG1716	ATPase activity
NCgl0052	COG0730	response to heat
NCgl0053	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NCgl0054	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NCgl0055	COG1937	Protein conserved in bacteria
NCgl0064	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NCgl0066	COG2851	Citrate transporter
NCgl0067	COG3290	protein histidine kinase activity
NCgl0068	COG4565	transcriptional regulatory protein
NCgl0069	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NCgl0071	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NCgl0075	COG0402	S-adenosylhomocysteine deaminase activity
NCgl0078	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NCgl0084	COG0832	Belongs to the urease beta subunit family
NCgl0085	COG0804	urea catabolic process
NCgl0086	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NCgl0087	COG0830	nickel cation binding
NCgl0088	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NCgl0089	COG0829	nickel cation binding
NCgl0091	COG2814	Major facilitator Superfamily
NCgl0093	COG0326	Molecular chaperone. Has ATPase activity
NCgl0094	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NCgl0098	COG1012	belongs to the aldehyde dehydrogenase family
NCgl0099	COG0667	Aldo Keto reductase
NCgl0100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NCgl0102	COG2149	membrane
NCgl0106	COG0346	lactoylglutathione lyase activity
NCgl0109	COG2814	Major facilitator Superfamily
NCgl0111	COG1070	Carbohydrate kinase
NCgl0112	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NCgl0113	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NCgl0114	COG3177	Filamentation induced by cAMP protein fic
NCgl0119	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NCgl0131	COG2860	membrane
NCgl0135	COG3180	Ammonia monooxygenase
NCgl0137	COG0730	response to heat
NCgl0139	COG1643	Atp-dependent helicase
NCgl0140	COG0110	maltose O-acetyltransferase activity
NCgl0142	COG2818	Glycosylase
NCgl0143	COG1280	lysine exporter protein (LysE YggA)
NCgl0149	COG0251	oxidation-reduction process
NCgl0151	COG3590	peptidase
NCgl0154	COG2188	Transcriptional regulator
NCgl0155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NCgl0158	COG3718	enzyme involved in inositol metabolism
NCgl0159	COG3962	Belongs to the TPP enzyme family
NCgl0161	COG0673	inositol 2-dehydrogenase activity
NCgl0162	COG1082	Xylose isomerase domain protein TIM barrel
NCgl0165	COG2161	toxin-antitoxin pair type II binding
NCgl0168	COG0673	inositol 2-dehydrogenase activity
NCgl0171	COG1278	Cold shock
NCgl0176	COG1609	Transcriptional regulator
NCgl0178	COG2814	Major facilitator Superfamily
NCgl0179	COG2826	transposase and inactivated derivatives, IS30 family
NCgl0181	COG0069	glutamate synthase activity
NCgl0181	COG0070	glutamate synthase
NCgl0181	COG0067	glutamate synthase
NCgl0186	COG1028	Short-chain dehydrogenase reductase Sdr
NCgl0187	COG0277	FAD linked oxidase domain protein
NCgl0194	COG2258	MOSC domain
NCgl0195	COG1216	Glycosyl transferase, family 2
NCgl0203	COG1115	amino acid carrier protein
NCgl0207	COG0521	Mo-molybdopterin cofactor biosynthetic process
NCgl0207	COG0315	cyclic pyranopterin monophosphate synthase activity
NCgl0208	COG0315	cyclic pyranopterin monophosphate synthase activity
NCgl0211	COG0725	ABC transporter, periplasmic molybdate-binding protein
NCgl0213	COG3842	ATPase activity
NCgl0214	COG1950	PFAM Membrane protein of
NCgl0215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NCgl0220	COG1231	oxidoreductase activity
NCgl0221	COG2239	Acts as a magnesium transporter
NCgl0222	COG0471	metal ion transport
NCgl0223	COG0287	Prephenate dehydrogenase
NCgl0226	COG3237	CsbD-like
NCgl0228	COG2409	Drug exporters of the RND superfamily
NCgl0229	COG0343	queuine tRNA-ribosyltransferase activity
NCgl0233	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NCgl0237	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NCgl0241	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NCgl0242	COG3442	glutamine amidotransferase
NCgl0243	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NCgl0245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NCgl0246	COG0697	spore germination
NCgl0247	COG0527	aspartate kinase activity
NCgl0248	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NCgl0254	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NCgl0258	COG0798	PFAM Bile acid sodium symporter
NCgl0259	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCgl0263	COG0651	ATP synthesis coupled electron transport
NCgl0264	COG1006	Multisubunit Na H antiporter MnhC subunit
NCgl0265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NCgl0265	COG2111	Na H antiporter
NCgl0268	COG0745	RESPONSE REGULATOR receiver
NCgl0269	COG3850	Histidine kinase
NCgl0269	COG5002	protein histidine kinase activity
NCgl0274	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NCgl0277	COG0251	oxidation-reduction process
NCgl0278	COG0477	Major facilitator Superfamily
NCgl0281	COG1028	Short-chain dehydrogenase reductase Sdr
NCgl0283	COG1960	acyl-CoA dehydrogenase activity
NCgl0285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NCgl0286	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NCgl0289	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NCgl0302	COG1205	dead DEAH box helicase
NCgl0302	COG1111	helicase
NCgl0303	COG1278	Cold shock
NCgl0304	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NCgl0304	COG1754	DNA topoisomerase type I activity
NCgl0310	COG0564	pseudouridine synthase activity
NCgl0316	COG2814	Major facilitator Superfamily
NCgl0322	COG0737	Belongs to the 5'-nucleotidase family
NCgl0322	COG1525	nuclease
NCgl0322	COG4085	toxin activity
NCgl0324	COG1064	alcohol dehydrogenase
NCgl0327	COG1088	dTDP-glucose 4,6-dehydratase activity
NCgl0328	COG0778	Nitroreductase
NCgl0329	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NCgl0333	COG1505	serine-type exopeptidase activity
NCgl0337	COG0489	protein tyrosine kinase activity
NCgl0338	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCgl0340	COG1086	Polysaccharide biosynthesis protein
NCgl0341	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NCgl0342	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NCgl0344	COG2244	polysaccharide biosynthetic process
NCgl0345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NCgl0346	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NCgl0347	COG1215	transferase activity, transferring glycosyl groups
NCgl0350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NCgl0350	COG2755	lipolytic protein G-D-S-L family
NCgl0355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NCgl0356	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NCgl0357	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NCgl0358	COG1396	sequence-specific DNA binding
NCgl0358	COG3800	Transcriptional regulator
NCgl0360	COG1053	succinate dehydrogenase
NCgl0361	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NCgl0365	COG2733	membrane
NCgl0368	COG1309	transcriptional regulator
NCgl0371	COG0788	formyltetrahydrofolate deformylase activity
NCgl0372	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NCgl0374	COG1937	Protein conserved in bacteria
NCgl0378	COG4558	Periplasmic binding protein
NCgl0379	COG4139	cobalamin transport
NCgl0380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NCgl0386	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NCgl0388	COG0318	PFAM AMP-dependent synthetase and ligase
NCgl0391	COG5002	protein histidine kinase activity
NCgl0392	COG0745	RESPONSE REGULATOR receiver
NCgl0394	COG0577	efflux transmembrane transporter activity
NCgl0398	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NCgl0402	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NCgl0403	COG0181	hydroxymethylbilane synthase activity
NCgl0406	COG0477	Major facilitator Superfamily
NCgl0407	COG1082	Xylose isomerase domain protein TIM barrel
NCgl0407	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NCgl0408	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NCgl0409	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NCgl0410	COG0222	ribosome binding
NCgl0411	COG3842	ATPase activity
NCgl0414	COG1648	precorrin-2 dehydrogenase activity
NCgl0414	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NCgl0416	COG0113	porphobilinogen synthase activity
NCgl0419	COG2217	Heavy metal translocating P-type atpase
NCgl0420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NCgl0422	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NCgl0423	COG0406	alpha-ribazole phosphatase activity
NCgl0425	COG0785	Cytochrome C biogenesis protein
NCgl0426	COG1333	cytochrome c biogenesis protein
NCgl0427	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NCgl0438	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NCgl0439	COG0583	DNA-binding transcription factor activity
NCgl0446	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NCgl0447	COG2154	pterin-4-alpha-carbinolamine dehydratase
NCgl0448	COG3340	Belongs to the peptidase S51 family
NCgl0449	COG4948	Mandelate Racemase Muconate Lactonizing
NCgl0452	COG0438	transferase activity, transferring glycosyl groups
NCgl0452	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NCgl0453	COG1113	amino acid transport
NCgl0454	COG2226	methyltransferase
NCgl0456	COG0142	geranyltranstransferase activity
NCgl0457	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NCgl0459	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NCgl0468	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NCgl0471	COG0085	RNA polymerase activity
NCgl0472	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NCgl0478	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NCgl0480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NCgl0482	COG1120	ATPase activity
NCgl0483	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl0484	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl0485	COG0427	acetyl-CoA hydrolase
NCgl0505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NCgl0510	COG3845	ABC transporter
NCgl0517	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NCgl0519	COG1841	ribosomal large subunit assembly
NCgl0527	COG1028	Short-chain dehydrogenase reductase Sdr
NCgl0528	COG0574	Belongs to the PEP-utilizing enzyme family
NCgl0528	COG3848	Pyruvate phosphate dikinase
NCgl0531	COG1414	Transcriptional regulator
NCgl0532	COG0201	protein transport
NCgl0539	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NCgl0540	COG0202	RNA polymerase activity
NCgl0541	COG0203	ribosomal protein L17
NCgl0542	COG0101	tRNA pseudouridine synthase activity
NCgl0548	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NCgl0550	COG1404	Belongs to the peptidase S8 family
NCgl0552	COG1674	ftsk spoiiie
NCgl0558	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NCgl0563	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NCgl0565	COG0569	domain protein
NCgl0565	COG2985	domain, Protein
NCgl0568	COG0456	acetyltransferase
NCgl0569	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NCgl0570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NCgl0570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NCgl0573	COG0459	protein refolding
NCgl0579	COG0516	GMP reductase activity
NCgl0581	COG0583	DNA-binding transcription factor activity
NCgl0582	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NCgl0582	COG0519	Catalyzes the synthesis of GMP from XMP
NCgl0586	COG2197	response regulator
NCgl0591	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NCgl0594	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NCgl0599	COG2409	Drug exporters of the RND superfamily
NCgl0603	COG0702	epimerase
NCgl0604	COG0415	Belongs to the DNA photolyase family
NCgl0605	COG1216	Glycosyl transferase, family 2
NCgl0607	COG1136	(ABC) transporter
NCgl0607	COG0577	efflux transmembrane transporter activity
NCgl0608	COG2011	ABC-type metal ion transport system permease component
NCgl0609	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NCgl0610	COG1464	Belongs to the NlpA lipoprotein family
NCgl0611	COG0587	DNA-directed DNA polymerase activity
NCgl0616	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NCgl0618	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NCgl0619	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NCgl0624	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NCgl0625	COG2873	o-acetylhomoserine
NCgl0626	COG1966	Carbon starvation protein
NCgl0629	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NCgl0630	COG0372	Belongs to the citrate synthase family
NCgl0631	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NCgl0634	COG2838	Isocitrate dehydrogenase
NCgl0636	COG1120	ATPase activity
NCgl0637	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl0638	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl0640	COG2814	Major facilitator Superfamily
NCgl0642	COG2860	membrane
NCgl0645	COG1120	ATPase activity
NCgl0646	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl0647	COG0180	Tryptophanyl-tRNA synthetase
NCgl0648	COG1295	ribonuclease BN
NCgl0650	COG1686	Belongs to the peptidase S11 family
NCgl0652	COG0741	lytic transglycosylase activity
NCgl0652	COG0791	NLP P60 protein
NCgl0656	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NCgl0657	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NCgl0657	COG1473	amidohydrolase
NCgl0659	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NCgl0662	COG0523	cobalamin synthesis protein
NCgl0663	COG0492	ferredoxin-NADP+ reductase activity
NCgl0664	COG2079	MmgE PrpD family protein
NCgl0665	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NCgl0666	COG0372	Belongs to the citrate synthase family
NCgl0668	COG1396	sequence-specific DNA binding
NCgl0668	COG3800	Transcriptional regulator
NCgl0670	COG4770	biotin carboxylase activity
NCgl0671	COG2897	thiosulfate sulfurtransferase activity
NCgl0672	COG0189	ligase activity
NCgl0675	COG0424	maF-like protein
NCgl0677	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NCgl0678	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NCgl0682	COG3158	transport of potassium into the cell
NCgl0687	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NCgl0698	COG3842	ATPase activity
NCgl0704	COG0210	DNA helicase
NCgl0705	COG1201	RNA secondary structure unwinding
NCgl0707	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NCgl0708	COG1316	TRANSCRIPTIONal
NCgl0716	COG1482	cell wall glycoprotein biosynthetic process
NCgl0721	COG0745	RESPONSE REGULATOR receiver
NCgl0722	COG5002	protein histidine kinase activity
NCgl0723	COG5401	PFAM Sporulation and spore germination
NCgl0725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NCgl0726	COG0653	protein targeting
NCgl0727	COG1011	Hydrolase
NCgl0729	COG1162	GTPase activity
NCgl0730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NCgl0737	COG0513	Belongs to the DEAD box helicase family
NCgl0742	COG0210	DNA helicase
NCgl0743	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NCgl0744	COG2816	NAD+ diphosphatase activity
NCgl0749	COG3480	Lon protease (S16) C-terminal proteolytic domain
NCgl0752	COG1615	UPF0182 protein
NCgl0753	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NCgl0754	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NCgl0755	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NCgl0765	COG0483	inositol monophosphate 1-phosphatase activity
NCgl0766	COG0483	inositol monophosphate 1-phosphatase activity
NCgl0768	COG2884	Cell division ATP-binding protein ftsE
NCgl0769	COG2177	Part of the ABC transporter FtsEX involved in
NCgl0771	COG3189	MarR family transcriptional regulator
NCgl0773	COG1132	(ABC) transporter
NCgl0773	COG2375	cellular response to nickel ion
NCgl0774	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NCgl0782	COG1061	Type III restriction enzyme res subunit
NCgl0785	COG1652	LysM domain
NCgl0790	COG2252	PERMEase
NCgl0791	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NCgl0795	COG0372	Belongs to the citrate synthase family
NCgl0796	COG0545	Peptidyl-prolyl cis-trans isomerase
NCgl0799	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NCgl0801	COG3757	hydrolase, family 25
NCgl0802	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NCgl0805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NCgl0808	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NCgl0811	COG1218	3'(2'),5'-bisphosphate nucleotidase
NCgl0812	COG1201	RNA secondary structure unwinding
NCgl0813	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NCgl0814	COG3304	Inner membrane component domain
NCgl0815	COG0586	Pfam SNARE associated Golgi protein
NCgl0817	COG0166	Belongs to the GPI family
NCgl0819	COG1605	Chorismate mutase
NCgl0822	COG0577	efflux transmembrane transporter activity
NCgl0822	COG1136	(ABC) transporter
NCgl0824	COG0739	heme binding
NCgl0827	COG0138	bifunctional purine biosynthesis protein purh
NCgl0832	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NCgl0835	COG0659	secondary active sulfate transmembrane transporter activity
NCgl0839	COG0745	RESPONSE REGULATOR receiver
NCgl0841	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NCgl0845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NCgl0846	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NCgl0850	COG2807	transmembrane transport
NCgl0854	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
NCgl0856	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NCgl0857	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NCgl0859	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NCgl0861	COG0657	acetylesterase activity
NCgl0863	COG2801	Transposase and inactivated derivatives
NCgl0865	COG0277	FAD linked oxidase domain protein
NCgl0868	COG2801	Transposase and inactivated derivatives
NCgl0871	COG0084	hydrolase, TatD family'
NCgl0872	COG3583	domain protein
NCgl0873	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NCgl0874	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NCgl0875	COG0488	(ABC) transporter
NCgl0880	COG2326	polyphosphate kinase activity
NCgl0881	COG0561	phosphatase activity
NCgl0887	COG2409	Drug exporters of the RND superfamily
NCgl0888	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NCgl0892	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NCgl0896	COG0411	ABC transporter
NCgl0898	COG0193	aminoacyl-tRNA hydrolase activity
NCgl0901	COG0193	aminoacyl-tRNA hydrolase activity
NCgl0902	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NCgl0905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NCgl0906	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NCgl0908	COG2132	Multicopper oxidase
NCgl0911	COG4585	Histidine kinase
NCgl0912	COG2909	trisaccharide binding
NCgl0914	COG1132	(ABC) transporter
NCgl0915	COG1132	(ABC) transporter
NCgl0916	COG0405	Gamma-glutamyltransferase
NCgl0923	COG1309	transcriptional regulator
NCgl0927	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NCgl0928	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NCgl0929	COG0531	amino acid
NCgl0931	COG3956	TIGRFAM MazG family protein
NCgl0939	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NCgl0943	COG2207	Transcriptional regulator
NCgl0946	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NCgl0948	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NCgl0950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NCgl0951	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NCgl0962	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NCgl0963	COG1914	H( )-stimulated, divalent metal cation uptake system
NCgl0965	COG2188	Transcriptional regulator
NCgl0967	COG0114	fumarate hydratase activity
NCgl0973	COG1960	acyl-CoA dehydrogenase activity
NCgl0976	COG1494	fructose-1,6-bisphosphatase
NCgl0979	COG2814	Major facilitator Superfamily
NCgl0981	COG1570	exodeoxyribonuclease VII activity
NCgl0984	COG0628	permease
NCgl0986	COG0733	neurotransmitter:sodium symporter activity
NCgl0988	COG0012	GTP binding
NCgl0989a	COG3549	Plasmid maintenance system killer
NCgl0990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NCgl0992	COG0300	oxidoreductase activity
NCgl0993	COG3547	Transposase (IS116 IS110 IS902 family)
NCgl0994	COG3300	MHYT domain
NCgl0994	COG5001	Diguanylate cyclase
NCgl1003	COG0656	L-ascorbic acid biosynthetic process
NCgl1004	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NCgl1005	COG0702	epimerase
NCgl1013	COG0406	alpha-ribazole phosphatase activity
NCgl1016	COG0488	(ABC) transporter
NCgl1018	COG2824	Alkylphosphonate utilization operon protein PhnA
NCgl1020	COG2814	Major facilitator Superfamily
NCgl1022	COG1104	cysteine desulfurase activity
NCgl1024	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NCgl1027	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NCgl1028	COG2315	Protein conserved in bacteria
NCgl1029	COG0095	Lipoate-protein ligase
NCgl1031	COG2814	Major facilitator Superfamily
NCgl1033	COG4721	ABC-type cobalt transport system, permease component
NCgl1034	COG1122	ATPase activity
NCgl1037	COG0387	Pfam Sodium calcium exchanger
NCgl1040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NCgl1041	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NCgl1043	COG2354	Protein conserved in bacteria
NCgl1044	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NCgl1048	COG5640	endopeptidase activity
NCgl1050	COG3949	Membrane
NCgl1053	COG1217	gtp-binding protein TYPA
NCgl1054	COG0747	negative chemotaxis
NCgl1061	COG2171	N-acyltransferase activity
NCgl1062	COG1113	amino acid transport
NCgl1064	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NCgl1066	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NCgl1067	COG0463	Glycosyl transferase, family 2
NCgl1072	COG0297	glycogen (starch) synthase activity
NCgl1074	COG4122	O-methyltransferase activity
NCgl1075	COG1595	DNA-templated transcription, initiation
NCgl1084	COG0567	Dehydrogenase, E1 component
NCgl1084	COG0508	dehydrogenase complex catalyzes the overall conversion of
NCgl1087	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NCgl1088	COG2272	Belongs to the type-B carboxylesterase lipase family
NCgl1092	COG2814	Major facilitator Superfamily
NCgl1094	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NCgl1101	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NCgl1102	COG4988	ABC transporter
NCgl1103	COG1294	oxidase, subunit
NCgl1104	COG1271	oxidase subunit
NCgl1110	COG1309	transcriptional regulator
NCgl1111	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NCgl1112	COG1454	alcohol dehydrogenase
NCgl1116	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NCgl1117	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NCgl1121	COG0657	acetylesterase activity
NCgl1123	COG2353	YceI-like domain
NCgl1124	COG1846	Transcriptional regulator
NCgl1127	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NCgl1128	COG2217	Heavy metal translocating P-type atpase
NCgl1130	COG2357	RelA SpoT domain protein
NCgl1132	COG0018	arginyl-trna synthetase
NCgl1133	COG0019	diaminopimelate decarboxylase activity
NCgl1136	COG0460	homoserine dehydrogenase
NCgl1137	COG0083	homoserine kinase activity
NCgl1141	COG1140	nitrate reductase beta subunit
NCgl1144	COG0315	cyclic pyranopterin monophosphate synthase activity
NCgl1144	COG0521	Mo-molybdopterin cofactor biosynthetic process
NCgl1146	COG1253	flavin adenine dinucleotide binding
NCgl1148	COG0746	molybdenum cofactor guanylyltransferase activity
NCgl1150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NCgl1159	COG0356	it plays a direct role in the translocation of protons across the membrane
NCgl1160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NCgl1161	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NCgl1163	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NCgl1164	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NCgl1165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NCgl1166	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NCgl1168	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NCgl1170	COG0346	lactoylglutathione lyase activity
NCgl1173	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NCgl1174	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NCgl1175	COG1116	anion transmembrane transporter activity
NCgl1176	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NCgl1177	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NCgl1178	COG0366	Alpha amylase catalytic
NCgl1179	COG1119	ATPase activity
NCgl1183	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NCgl1187	COG1396	sequence-specific DNA binding
NCgl1196	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NCgl1199	COG0154	amidase activity
NCgl1202	COG0205	6-phosphofructokinase activity
NCgl1203	COG1609	Transcriptional regulator
NCgl1204	COG1129	ABC transporter
NCgl1205	COG1172	Belongs to the binding-protein-dependent transport system permease family
NCgl1206	COG1879	ABC-type sugar transport system periplasmic component
NCgl1207	COG1869	D-ribose catabolic process
NCgl1210	COG0385	Bile acid
NCgl1213	COG0667	Aldo Keto reductase
NCgl1214	COG1279	arginine transmembrane transporter activity
NCgl1215	COG0583	DNA-binding transcription factor activity
NCgl1216	COG0435	Glutathione S-transferase
NCgl1219	COG0129	dihydroxy-acid dehydratase activity
NCgl1221	COG0668	transmembrane transport
NCgl1222	COG0028	Belongs to the TPP enzyme family
NCgl1223	COG0440	acetolactate synthase activity
NCgl1231	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NCgl1237	COG0473	3-isopropylmalate dehydrogenase activity
NCgl1241	COG0179	Fumarylacetoacetate (FAA) hydrolase
NCgl1244	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NCgl1245	COG3655	Transcriptional regulator
NCgl1253	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NCgl1255	COG0058	SHG alpha-glucan phosphorylase activity
NCgl1257	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NCgl1258	COG0730	response to heat
NCgl1260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NCgl1262	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NCgl1263	COG0066	3-isopropylmalate dehydratase activity
NCgl1264	COG0406	alpha-ribazole phosphatase activity
NCgl1264	COG0494	nUDIX hydrolase
NCgl1267	COG1181	Belongs to the D-alanine--D-alanine ligase family
NCgl1269	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NCgl1270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NCgl1271	COG1461	Dihydroxyacetone kinase
NCgl1272	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NCgl1274	COG0742	ribosomal rna small subunit methyltransferase
NCgl1278	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NCgl1302	COG0656	L-ascorbic acid biosynthetic process
NCgl1304	COG0539	negative regulation of cytoplasmic translation
NCgl1305	COG1263	PTS System
NCgl1305	COG2190	(PTS) system
NCgl1305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCgl1306	COG0237	dephospho-CoA kinase activity
NCgl1310	COG0477	Major facilitator Superfamily
NCgl1311	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NCgl1317	COG1733	regulation of RNA biosynthetic process
NCgl1318	COG0702	epimerase
NCgl1319	COG3973	AAA domain
NCgl1324	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NCgl1329	COG4209	transmembrane transport
NCgl1332	COG3842	ATPase activity
NCgl1334	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NCgl1335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NCgl1336	COG0072	phenylalanine-tRNA ligase activity
NCgl1336	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NCgl1340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NCgl1341	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NCgl1343	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NCgl1344	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NCgl1346	COG0137	argininosuccinate synthase activity
NCgl1347	COG0165	Argininosuccinate lyase
NCgl1351	COG2835	tetraacyldisaccharide 4'-kinase activity
NCgl1352	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NCgl1355	COG0647	UMP catabolic process
NCgl1358	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NCgl1363	COG0494	nUDIX hydrolase
NCgl1364	COG4974	Belongs to the 'phage' integrase family
NCgl1365	COG0488	(ABC) transporter
NCgl1369	COG2897	thiosulfate sulfurtransferase activity
NCgl1370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NCgl1372	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NCgl1373	COG1160	GTP binding
NCgl1377	COG1132	(ABC) transporter
NCgl1378	COG1132	(ABC) transporter
NCgl1379	COG0428	transporter
NCgl1380	COG0025	NhaP-type Na H and K H
NCgl1382	COG3012	SEC-C Motif Domain Protein
NCgl1384	COG0653	protein targeting
NCgl1385	COG1716	ATPase activity
NCgl1392	COG1253	flavin adenine dinucleotide binding
NCgl1393	COG1253	flavin adenine dinucleotide binding
NCgl1394	COG0513	Belongs to the DEAD box helicase family
NCgl1396	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NCgl1400	COG0842	Transport permease protein
NCgl1402	COG3639	organic phosphonate transmembrane transporter activity
NCgl1403	COG3639	organic phosphonate transmembrane transporter activity
NCgl1404	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NCgl1407	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NCgl1407	COG0351	phosphomethylpyrimidine kinase
NCgl1407	COG0352	thiamine-phosphate diphosphorylase activity
NCgl1408	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NCgl1409	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NCgl1411	COG0477	Major facilitator Superfamily
NCgl1412	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NCgl1413	COG1971	Probably functions as a manganese efflux pump
NCgl1417	COG0659	secondary active sulfate transmembrane transporter activity
NCgl1423	COG0463	Glycosyl transferase, family 2
NCgl1433	COG0805	protein transport
NCgl1434	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NCgl1439	COG4122	O-methyltransferase activity
NCgl1442	COG1362	aminopeptidase activity
NCgl1445	COG2814	Major facilitator Superfamily
NCgl1446	COG1027	Aspartate ammonia-lyase
NCgl1449	COG0546	phosphoglycolate phosphatase activity
NCgl1450	COG1410	methionine synthase
NCgl1450	COG0646	methionine synthase
NCgl1452	COG2072	flavoprotein involved in K transport
NCgl1453	COG0798	PFAM Bile acid sodium symporter
NCgl1454	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCgl1455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NCgl1458	COG1968	undecaprenyl-diphosphatase activity
NCgl1459	COG0667	Aldo Keto reductase
NCgl1461	COG0167	dihydroorotate dehydrogenase activity
NCgl1466	COG1881	PFAM PEBP family protein
NCgl1468	COG1132	(ABC) transporter
NCgl1473	COG0398	Pfam SNARE associated Golgi protein
NCgl1479	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NCgl1480	COG3883	PFAM NLP P60 protein
NCgl1480	COG0791	NLP P60 protein
NCgl1482	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NCgl1483	COG1309	transcriptional regulator
NCgl1486	COG3830	Belongs to the UPF0237 family
NCgl1487	COG2848	UPF0210 protein
NCgl1488	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NCgl1493	COG0488	(ABC) transporter
NCgl1499	COG0822	iron-sulfur transferase activity
NCgl1501	COG0396	ATPase activity
NCgl1512	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NCgl1513	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NCgl1520	COG2423	ornithine cyclodeaminase activity
NCgl1521	COG0004	ammonium transporteR
NCgl1522	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NCgl1523	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NCgl1524	COG0149	triose-phosphate isomerase activity
NCgl1525	COG0126	phosphoglycerate kinase activity
NCgl1526	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NCgl1527	COG1481	regulation of sporulation
NCgl1528	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NCgl1530	COG0322	excinuclease ABC activity
NCgl1539	COG0242	peptide deformylase activity
NCgl1541	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NCgl1543	COG1758	RNA polymerase activity
NCgl1544	COG0194	GDP metabolic process
NCgl1546	COG0284	orotidine-5'-phosphate decarboxylase activity
NCgl1547	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NCgl1548	COG0505	Belongs to the CarA family
NCgl1549	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NCgl1550	COG0540	Belongs to the ATCase OTCase family
NCgl1551	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NCgl1556	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NCgl1558	COG0006	proline dipeptidase activity
NCgl1559	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NCgl1560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NCgl1561	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NCgl1564	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl1566	COG1120	ATPase activity
NCgl1567	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NCgl1568	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NCgl1569	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NCgl1570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NCgl1573	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NCgl1575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NCgl1580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NCgl1583	COG1760	l-serine dehydratase
NCgl1584	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NCgl1585	COG0124	histidyl-tRNA synthetase
NCgl1587	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NCgl1590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NCgl1591	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NCgl1592	COG0747	negative chemotaxis
NCgl1593	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NCgl1594	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NCgl1597	COG0632	four-way junction helicase activity
NCgl1598	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NCgl1599	COG0217	transcriptional regulatory protein
NCgl1600	COG1946	Acyl-CoA thioesterase
NCgl1603	COG0438	transferase activity, transferring glycosyl groups
NCgl1604	COG1560	Kdo2-lipid A biosynthetic process
NCgl1605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NCgl1607	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NCgl1608	COG2837	iron assimilation
NCgl1609	COG2847	Copper chaperone PCu(A)C
NCgl1614	COG0456	acetyltransferase
NCgl1614	COG0454	-acetyltransferase
NCgl1623	COG1129	ABC transporter
NCgl1648	COG0671	phosphoesterase, PA-phosphatase related
NCgl1648	COG2453	phosphatase
NCgl1650	COG2186	Transcriptional regulator
NCgl1662	COG2801	Transposase and inactivated derivatives
NCgl1716	COG0542	response to heat
NCgl1807	COG2801	Transposase and inactivated derivatives
NCgl1818	COG1929	Belongs to the glycerate kinase type-1 family
NCgl1823	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NCgl1824	COG3253	May function as heme-dependent peroxidase
NCgl1826	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NCgl1827	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NCgl1828	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NCgl1830	COG0756	dUTP diphosphatase activity
NCgl1834	COG0483	inositol monophosphate 1-phosphatase activity
NCgl1837	COG2311	Membrane
NCgl1839	COG1061	Type III restriction enzyme res subunit
NCgl1845	COG1321	iron dependent repressor
NCgl1846	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NCgl1850	COG0583	DNA-binding transcription factor activity
NCgl1852	COG1643	Atp-dependent helicase
NCgl1856	COG1349	DNA-binding transcription factor activity
NCgl1858	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NCgl1860	COG1105	Belongs to the carbohydrate kinase PfkB family
NCgl1861	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NCgl1861	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NCgl1861	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NCgl1864	COG2233	PERMEase
NCgl1865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NCgl1868	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NCgl1869	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NCgl1871	COG1196	nuclear chromosome segregation
NCgl1875	COG1126	abc transporter atp-binding protein
NCgl1876	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NCgl1877	COG0765	amino acid transport
NCgl1878	COG0765	amino acid transport
NCgl1879	COG2137	regulation of response to DNA damage stimulus
NCgl1883	COG1268	BioY protein
NCgl1884	COG1122	ATPase activity
NCgl1886	COG1842	Phage shock protein A
NCgl1887	COG1396	sequence-specific DNA binding
NCgl1893	COG1674	ftsk spoiiie
NCgl1895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NCgl1896	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NCgl1897	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NCgl1898	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NCgl1900	COG1185	polyribonucleotide nucleotidyltransferase activity
NCgl1904	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NCgl1906	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NCgl1908	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NCgl1909	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NCgl1910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NCgl1913	COG0779	Required for maturation of 30S ribosomal subunits
NCgl1915	COG4166	transmembrane transport
NCgl1916	COG0601	transmembrane transport
NCgl1917	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NCgl1918	COG4172	Belongs to the ABC transporter superfamily
NCgl1919	COG0442	prolyl-tRNA aminoacylation
NCgl1920	COG3022	response to hydroperoxide
NCgl1923	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NCgl1923	COG1648	precorrin-2 dehydrogenase activity
NCgl1924	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NCgl1934	COG2197	response regulator
NCgl1935	COG3850	Histidine kinase
NCgl1936	COG0577	efflux transmembrane transporter activity
NCgl1937	COG1136	(ABC) transporter
NCgl1937	COG0577	efflux transmembrane transporter activity
NCgl1938	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NCgl1939	COG0750	zinc metalloprotease
NCgl1940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NCgl1943	COG1131	(ABC) transporter
NCgl1944	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NCgl1947	COG0233	cytoplasmic translational termination
NCgl1949	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NCgl1950	COG0052	Belongs to the universal ribosomal protein uS2 family
NCgl1952	COG4974	Belongs to the 'phage' integrase family
NCgl1954	COG0606	chelatase, subunit chli
NCgl1955	COG0792	nuclease activity
NCgl1957	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NCgl1958	COG0681	Belongs to the peptidase S26 family
NCgl1960	COG0335	large ribosomal subunit rRNA binding
NCgl1961	COG0352	thiamine-phosphate diphosphorylase activity
NCgl1962	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NCgl1962	COG2022	thiamine diphosphate biosynthetic process
NCgl1964	COG2022	thiamine diphosphate biosynthetic process
NCgl1965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NCgl1967	COG1609	Transcriptional regulator
NCgl1968	COG0471	metal ion transport
NCgl1969	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NCgl1972	COG0336	Belongs to the RNA methyltransferase TrmD family
NCgl1974	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NCgl1981	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NCgl1986	COG1196	nuclear chromosome segregation
NCgl1987	COG1254	Belongs to the acylphosphatase family
NCgl1993	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NCgl1994	COG0571	ribonuclease III activity
NCgl1997	COG1132	(ABC) transporter
NCgl1998	COG1132	(ABC) transporter
NCgl1999	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NCgl2000	COG1929	Belongs to the glycerate kinase type-1 family
NCgl2006	COG0058	SHG alpha-glucan phosphorylase activity
NCgl2007	COG2514	catechol 2,3-dioxygenase activity
NCgl2008	COG0469	pyruvate kinase activity
NCgl2010	COG0134	indole-3-glycerol-phosphate synthase activity
NCgl2012	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NCgl2014	COG0483	inositol monophosphate 1-phosphatase activity
NCgl2015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NCgl2016	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NCgl2020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NCgl2021	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NCgl2027	COG2264	protein methyltransferase activity
NCgl2029	COG0673	inositol 2-dehydrogenase activity
NCgl2030	COG1609	Transcriptional regulator
NCgl2031	COG1120	ATPase activity
NCgl2032	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NCgl2044	COG1739	Uncharacterized protein family UPF0029
NCgl2046	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NCgl2053	COG1028	Short-chain dehydrogenase reductase Sdr
NCgl2054	COG0019	diaminopimelate decarboxylase activity
NCgl2058	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NCgl2060	COG0488	(ABC) transporter
NCgl2062	COG0252	asparaginase activity
NCgl2064	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NCgl2068	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NCgl2070	COG3599	regulation of cell shape
NCgl2072	COG1799	cell septum assembly
NCgl2073	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NCgl2074	COG1496	oxidoreductase activity
NCgl2075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NCgl2076	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NCgl2077	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NCgl2078	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NCgl2080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NCgl2081	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NCgl2083	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NCgl2084	COG0768	penicillin binding
NCgl2086	COG0275	rRNA processing
NCgl2090	COG0456	acetyltransferase
NCgl2092	COG0142	geranyltranstransferase activity
NCgl2095	COG0515	serine threonine protein kinase
NCgl2095	COG2815	serine threonine protein kinase
NCgl2096	COG5650	phosphatidylinositol metabolic process
NCgl2098	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NCgl2105	COG1940	carbohydrate kinase activity
NCgl2106	COG0438	transferase activity, transferring glycosyl groups
NCgl2108	COG0791	NLP P60 protein
NCgl2109	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NCgl2110	COG0723	plastoquinol--plastocyanin reductase activity
NCgl2111	COG2010	Cytochrome c
NCgl2112	COG1845	cytochrome c oxidase, subunit III
NCgl2115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NCgl2120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NCgl2121	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NCgl2123	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NCgl2124	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NCgl2126	COG0508	dehydrogenase complex catalyzes the overall conversion of
NCgl2130	COG0569	domain protein
NCgl2130	COG2985	domain, Protein
NCgl2131	COG2826	transposase and inactivated derivatives, IS30 family
NCgl2133	COG0174	glutamine synthetase
NCgl2137	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NCgl2139	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NCgl2147	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NCgl2148	COG0174	glutamine synthetase
NCgl2153	COG0557	exoribonuclease II activity
NCgl2157	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NCgl2157	COG3323	Protein of unknown function (DUF1653)
NCgl2167	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NCgl2173	COG0596	Alpha beta hydrolase
NCgl2174	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NCgl2186	COG3387	PFAM Glycoside hydrolase 15-related
NCgl2188	COG0358	DNA primase activity
NCgl2191	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NCgl2193	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NCgl2198	COG0423	glycine-tRNA ligase activity
NCgl2203	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NCgl2205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NCgl2207	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NCgl2210	COG0484	heat shock protein binding
NCgl2218	COG1132	(ABC) transporter
NCgl2221	COG0366	Alpha amylase catalytic
NCgl2223	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NCgl2228	COG1114	Component of the transport system for branched-chain amino acids
NCgl2229	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NCgl2230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NCgl2233	COG0247	lactate metabolic process
NCgl2233	COG0277	FAD linked oxidase domain protein
NCgl2238	COG0747	negative chemotaxis
NCgl2239	COG0601	transmembrane transport
NCgl2240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NCgl2243	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NCgl2245	COG0385	Bile acid
NCgl2246	COG0676	glucose-6-phosphate 1-epimerase activity
NCgl2247	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NCgl2248	COG2224	Isocitrate lyase
NCgl2251	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NCgl2257	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NCgl2259	COG0481	GTPase activity
NCgl2262	COG1280	lysine exporter protein (LysE YggA)
NCgl2267	COG1307	EDD domain protein, DegV family
NCgl2268	COG0406	alpha-ribazole phosphatase activity
NCgl2270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NCgl2273	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NCgl2274	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NCgl2275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NCgl2281	COG1530	ribonuclease E activity
NCgl2292	COG0285	dihydrofolate synthase activity
NCgl2293	COG0525	valine-tRNA ligase activity
NCgl2295	COG0443	Heat shock 70 kDa protein
NCgl2297	COG0039	L-malate dehydrogenase activity
NCgl2298	COG1309	transcriptional regulator
NCgl2302	COG2814	Major facilitator Superfamily
NCgl2304	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NCgl2308	COG1414	Transcriptional regulator
NCgl2309	COG0183	Belongs to the thiolase family
NCgl2310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NCgl2313	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NCgl2314	COG3485	protocatechuate 3,4-dioxygenase
NCgl2315	COG3485	protocatechuate 3,4-dioxygenase
NCgl2317	COG4829	muconolactone delta-isomerase
NCgl2318	COG4948	Mandelate Racemase Muconate Lactonizing
NCgl2319	COG3485	protocatechuate 3,4-dioxygenase
NCgl2320	COG4638	Rieske (2fe-2S)
NCgl2323	COG1028	Short-chain dehydrogenase reductase Sdr
NCgl2325	COG2814	Major facilitator Superfamily
NCgl2327	COG0740	serine-type endopeptidase activity
NCgl2328	COG0740	serine-type endopeptidase activity
NCgl2339	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NCgl2350	COG4172	Belongs to the ABC transporter superfamily
NCgl2351	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NCgl2352	COG0601	transmembrane transport
NCgl2353	COG0747	negative chemotaxis
NCgl2355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NCgl2358	COG4221	oxidoreductase activity
NCgl2361	COG1119	ATPase activity
NCgl2362	COG2346	COG2346, Truncated hemoglobins
NCgl2371	COG1785	Belongs to the alkaline phosphatase family
NCgl2377	COG3842	ATPase activity
NCgl2378	COG0463	Glycosyl transferase, family 2
NCgl2382	COG1691	(AIR) carboxylase
NCgl2383	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NCgl2384	COG3622	Belongs to the hyi family
NCgl2385	COG4221	oxidoreductase activity
NCgl2386	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NCgl2388	COG1376	ErfK ybiS ycfS ynhG family protein
NCgl2395	COG2066	Belongs to the glutaminase family
NCgl2398	COG1904	glucuronate isomerase
NCgl2398	COG1102	Psort location Cytoplasmic, score
NCgl2399	COG3265	gluconokinase activity
NCgl2401	COG1335	isochorismatase
NCgl2405	COG0736	holo-[acyl-carrier-protein] synthase activity
NCgl2406	COG2814	Major facilitator Superfamily
NCgl2410	COG3835	regulator
NCgl2414	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NCgl2415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NCgl2422	COG1234	tRNA 3'-trailer cleavage
NCgl2423	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NCgl2427	COG3191	aminopeptidase activity
NCgl2431	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NCgl2437	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NCgl2440	COG2186	Transcriptional regulator
NCgl2443	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NCgl2446	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NCgl2449	COG0604	alcohol dehydrogenase
NCgl2450	COG2079	MmgE PrpD family protein
NCgl2453	COG0033	Phosphoglucomutase
NCgl2454	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NCgl2455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NCgl2456	COG4336	lyase activity
NCgl2465	COG1136	(ABC) transporter
NCgl2470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NCgl2472	COG2197	response regulator
NCgl2474	COG1045	serine acetyltransferase
NCgl2477	COG0045	succinate-CoA ligase (ADP-forming) activity
NCgl2478	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NCgl2483	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NCgl2487	COG0456	acetyltransferase
NCgl2489	COG1597	lipid kinase activity
NCgl2492	COG0354	folic acid binding
NCgl2494	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NCgl2499	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NCgl2500	COG0047	phosphoribosylformylglycinamidine synthase activity
NCgl2501	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NCgl2502	COG0386	Belongs to the glutathione peroxidase family
NCgl2508	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NCgl2509	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NCgl2510	COG0436	Aminotransferase
NCgl2511	COG0151	Belongs to the GarS family
NCgl2512	COG0537	adenosine 5'-monophosphoramidase activity
NCgl2514	COG3104	oligopeptide transport
NCgl2515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NCgl2516	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NCgl2517	COG2205	protein histidine kinase activity
NCgl2518	COG0745	RESPONSE REGULATOR receiver
NCgl2519	COG0789	Transcriptional regulator
NCgl2521	COG0028	Belongs to the TPP enzyme family
NCgl2523	COG1309	transcriptional regulator
NCgl2526	COG1053	succinate dehydrogenase
NCgl2527	COG0583	DNA-binding transcription factor activity
NCgl2528	COG1748	Saccharopine dehydrogenase
NCgl2535	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NCgl2538	COG1609	Transcriptional regulator
NCgl2540	COG1121	(ABC) transporter
NCgl2541	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NCgl2544	COG1053	succinate dehydrogenase
NCgl2551	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NCgl2552	COG0215	cysteine-tRNA ligase activity
NCgl2554	COG1621	beta-fructofuranosidase activity
NCgl2555	COG0363	glucosamine-6-phosphate deaminase activity
NCgl2556	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NCgl2557	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NCgl2562	COG4166	transmembrane transport
NCgl2564	COG0444	Belongs to the ABC transporter superfamily
NCgl2565	COG4608	Belongs to the ABC transporter superfamily
NCgl2566	COG1280	lysine exporter protein (LysE YggA)
NCgl2567	COG1522	sequence-specific DNA binding
NCgl2569	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NCgl2570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NCgl2573	COG2205	protein histidine kinase activity
NCgl2574	COG2847	Copper chaperone PCu(A)C
NCgl2575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NCgl2576	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NCgl2585	COG0542	response to heat
NCgl2587	COG2207	Transcriptional regulator
NCgl2592	COG2814	Major facilitator Superfamily
NCgl2594	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NCgl2595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NCgl2599	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NCgl2602	COG0302	gtp cyclohydrolase
NCgl2603	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NCgl2605	COG0037	tRNA processing
NCgl2606	COG2027	D-alanyl-D-alanine carboxypeptidase
NCgl2607	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NCgl2608	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NCgl2609	COG3766	membrane
NCgl2613	COG2190	(PTS) system
NCgl2613	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCgl2613	COG1263	PTS System
NCgl2614	COG1263	PTS System
NCgl2614	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NCgl2614	COG2190	(PTS) system
NCgl2616	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NCgl2619	COG1012	belongs to the aldehyde dehydrogenase family
NCgl2620	COG2326	polyphosphate kinase activity
NCgl2621	COG0459	protein refolding
NCgl2623	COG1100	Small GTP-binding protein
NCgl2633	COG2111	Na H antiporter
NCgl2633	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NCgl2634	COG1006	Multisubunit Na H antiporter MnhC subunit
NCgl2635	COG0651	ATP synthesis coupled electron transport
NCgl2637	COG2212	antiporter activity
NCgl2638	COG1320	monovalent cation:proton antiporter activity
NCgl2643	COG0242	peptide deformylase activity
NCgl2646	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NCgl2647	COG2814	Major facilitator Superfamily
NCgl2651	COG1131	(ABC) transporter
NCgl2655	COG0515	serine threonine protein kinase
NCgl2656	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NCgl2657	COG0280	phosphate acetyltransferase
NCgl2665	COG2801	Transposase and inactivated derivatives
NCgl2669	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NCgl2671	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NCgl2672	COG4129	membrane
NCgl2673	COG0191	fructose-bisphosphate aldolase activity
NCgl2676	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NCgl2678	COG2897	thiosulfate sulfurtransferase activity
NCgl2682	COG0542	response to heat
NCgl2684	COG0640	Transcriptional regulator
NCgl2698	COG1012	belongs to the aldehyde dehydrogenase family
NCgl2699	COG0789	Transcriptional regulator
NCgl2700	COG0484	heat shock protein binding
NCgl2701	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NCgl2702	COG0443	Heat shock 70 kDa protein
NCgl2713	COG0730	response to heat
NCgl2718	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NCgl2728	COG1162	GTPase activity
NCgl2730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NCgl2732	COG1122	ATPase activity
NCgl2736	COG1957	nucleoside hydrolase
NCgl2739	COG2818	Glycosylase
NCgl2740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NCgl2740	COG1017	nitric oxide dioxygenase activity
NCgl2742	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NCgl2743	COG3711	transcriptional antiterminator
NCgl2748	COG2826	transposase and inactivated derivatives, IS30 family
NCgl2750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NCgl2754	COG1472	Belongs to the glycosyl hydrolase 3 family
NCgl2757	COG4981	capsule polysaccharide biosynthetic process
NCgl2762	COG0438	transferase activity, transferring glycosyl groups
NCgl2764	COG0500	methyltransferase
NCgl2765	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NCgl2772	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NCgl2773	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NCgl2773	COG3321	synthase
NCgl2773	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NCgl2774	COG0318	PFAM AMP-dependent synthetase and ligase
NCgl2775	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
NCgl2777	COG5479	isomerase activity
NCgl2777	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NCgl2780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NCgl2781	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NCgl2782	COG0671	phosphoesterase, PA-phosphatase related
NCgl2783	COG1216	Glycosyl transferase, family 2
NCgl2785	COG0671	phosphoesterase, PA-phosphatase related
NCgl2791	COG0561	phosphatase activity
NCgl2793	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NCgl2794	COG2188	Transcriptional regulator
NCgl2799	COG0077	Prephenate dehydratase
NCgl2802	COG1316	TRANSCRIPTIONal
NCgl2808	COG2610	gluconate transmembrane transporter activity
NCgl2809	COG0469	pyruvate kinase activity
NCgl2810	COG0039	L-malate dehydrogenase activity
NCgl2814	COG2188	Transcriptional regulator
NCgl2815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NCgl2816	COG0477	Major facilitator Superfamily
NCgl2823	COG1473	amidohydrolase
NCgl2825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NCgl2827	COG0583	DNA-binding transcription factor activity
NCgl2828	COG2814	Major facilitator Superfamily
NCgl2834	COG2197	response regulator
NCgl2838	COG3764	Sortase (surface protein transpeptidase)
NCgl2839	COG0706	membrane insertase activity
NCgl2843	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NCgl2844	COG0564	pseudouridine synthase activity
NCgl2848	COG1842	Phage shock protein A
NCgl2859	COG2217	Heavy metal translocating P-type atpase
NCgl2862	COG2205	protein histidine kinase activity
NCgl2863	COG0745	RESPONSE REGULATOR receiver
NCgl2865	COG2132	Multicopper oxidase
NCgl2867	COG1063	alcohol dehydrogenase
NCgl2869	COG2608	mercury ion transmembrane transporter activity
NCgl2874	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NCgl2876	COG0477	Major facilitator Superfamily
NCgl2877	COG1695	Transcriptional regulator
NCgl2878	COG0305	Participates in initiation and elongation during chromosome replication
NCgl2879	COG0359	binds to the 23S rRNA
NCgl2880	COG0629	single-stranded DNA binding
NCgl2881	COG0360	Binds together with S18 to 16S ribosomal RNA
NCgl2884	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NCgl2886	COG1846	Transcriptional regulator
NCgl2890	COG1054	Belongs to the UPF0176 family
NCgl2892	COG1136	(ABC) transporter
NCgl2894	COG1260	myo-inositol-1-phosphate synthase
NCgl2896	COG4868	Belongs to the UPF0371 family
NCgl2897	COG0783	Belongs to the Dps family
NCgl2898	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NCgl2899	COG1690	Belongs to the RtcB family
NCgl2901	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NCgl2908	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NCgl2909	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NCgl2913	COG0778	Nitroreductase
NCgl2915	COG0495	leucyl-tRNA aminoacylation
NCgl2916	COG2832	Protein of unknown function (DUF454)
NCgl2919	COG0179	Fumarylacetoacetate (FAA) hydrolase
NCgl2922	COG2814	Major facilitator Superfamily
NCgl2923	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NCgl2927	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NCgl2928	COG0512	Glutamine amidotransferase of anthranilate synthase
NCgl2930	COG0135	phosphoribosylanthranilate isomerase activity
NCgl2930	COG0134	indole-3-glycerol-phosphate synthase activity
NCgl2931	COG0133	tryptophan synthase activity
NCgl2932	COG0159	tryptophan synthase activity
NCgl2934	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NCgl2935	COG1131	(ABC) transporter
NCgl2942	COG1902	pentaerythritol trinitrate reductase activity
NCgl2949	COG3104	oligopeptide transport
NCgl2950	COG1309	transcriptional regulator
NCgl2952	COG1454	alcohol dehydrogenase
NCgl2953	COG2814	Major facilitator Superfamily
NCgl2954	COG1414	Transcriptional regulator
NCgl2955	COG0673	inositol 2-dehydrogenase activity
NCgl2957	COG0673	inositol 2-dehydrogenase activity
NCgl2958	COG0673	inositol 2-dehydrogenase activity
NCgl2959	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NCgl2961	COG0477	Major facilitator Superfamily
NCgl2966	COG0351	phosphomethylpyrimidine kinase
NCgl2968	COG2608	mercury ion transmembrane transporter activity
NCgl2969	COG0477	Major facilitator Superfamily
NCgl2970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NCgl2973	COG0351	phosphomethylpyrimidine kinase
NCgl2975	COG2608	mercury ion transmembrane transporter activity
NCgl2976	COG1687	branched-chain amino acid
NCgl2977	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NCgl2978	COG1678	Uncharacterized ACR, COG1678
NCgl2979	COG0617	tRNA 3'-terminal CCA addition
NCgl2983	COG1595	DNA-templated transcription, initiation
NCgl2985	COG3118	belongs to the thioredoxin family
NCgl2986	COG0860	N-Acetylmuramoyl-L-alanine amidase
NCgl2986	COG3409	Peptidoglycan-binding domain 1 protein
NCgl2989	COG1192	Involved in chromosome partitioning
NCgl2990	COG0357	Ribosomal RNA small subunit methyltransferase G
NCgl2992	COG0594	ribonuclease P activity