locus-tag	class	description
CYL77_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYL77_RS00015	COG0592	DNA-directed DNA polymerase activity
CYL77_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYL77_RS00030	COG0187	DNA topoisomerase II activity
CYL77_RS00085	COG2855	membrane
CYL77_RS00090	COG0583	DNA-binding transcription factor activity
CYL77_RS00105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYL77_RS00105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYL77_RS00150	COG1764	response to oxidative stress
CYL77_RS00165	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYL77_RS00170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYL77_RS00175	COG1120	ATPase activity
CYL77_RS00185	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYL77_RS00190	COG1129	ABC transporter
CYL77_RS00215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS00220	COG1120	ATPase activity
CYL77_RS00240	COG2815	serine threonine protein kinase
CYL77_RS00240	COG0515	serine threonine protein kinase
CYL77_RS00245	COG0515	serine threonine protein kinase
CYL77_RS00250	COG0768	penicillin binding
CYL77_RS00270	COG1716	ATPase activity
CYL77_RS00310	COG0730	response to heat
CYL77_RS00315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYL77_RS00320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYL77_RS00325	COG1937	Protein conserved in bacteria
CYL77_RS00370	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CYL77_RS00380	COG2851	Citrate transporter
CYL77_RS00385	COG3290	protein histidine kinase activity
CYL77_RS00390	COG4565	transcriptional regulatory protein
CYL77_RS00395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYL77_RS00405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYL77_RS00450	COG0402	S-adenosylhomocysteine deaminase activity
CYL77_RS00465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CYL77_RS00495	COG0832	Belongs to the urease beta subunit family
CYL77_RS00500	COG0804	urea catabolic process
CYL77_RS00505	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CYL77_RS00510	COG0830	nickel cation binding
CYL77_RS00515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYL77_RS00520	COG0829	nickel cation binding
CYL77_RS00530	COG2814	Major facilitator Superfamily
CYL77_RS00540	COG0326	Molecular chaperone. Has ATPase activity
CYL77_RS00545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYL77_RS00565	COG1012	belongs to the aldehyde dehydrogenase family
CYL77_RS00570	COG0667	Aldo Keto reductase
CYL77_RS00575	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CYL77_RS00585	COG2149	membrane
CYL77_RS00610	COG0346	lactoylglutathione lyase activity
CYL77_RS00625	COG2814	Major facilitator Superfamily
CYL77_RS00635	COG1070	Carbohydrate kinase
CYL77_RS00640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYL77_RS00645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYL77_RS00650	COG3177	Filamentation induced by cAMP protein fic
CYL77_RS00675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYL77_RS00740	COG2860	membrane
CYL77_RS00760	COG3180	Ammonia monooxygenase
CYL77_RS00770	COG0730	response to heat
CYL77_RS00780	COG1643	Atp-dependent helicase
CYL77_RS00785	COG0110	maltose O-acetyltransferase activity
CYL77_RS00795	COG2818	Glycosylase
CYL77_RS00800	COG1280	lysine exporter protein (LysE YggA)
CYL77_RS00830	COG0251	oxidation-reduction process
CYL77_RS00840	COG3590	peptidase
CYL77_RS00855	COG2188	Transcriptional regulator
CYL77_RS00860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYL77_RS00875	COG3718	enzyme involved in inositol metabolism
CYL77_RS00880	COG3962	Belongs to the TPP enzyme family
CYL77_RS00890	COG0673	inositol 2-dehydrogenase activity
CYL77_RS00895	COG1082	Xylose isomerase domain protein TIM barrel
CYL77_RS00905	COG0673	inositol 2-dehydrogenase activity
CYL77_RS00910	COG2161	toxin-antitoxin pair type II binding
CYL77_RS00925	COG0673	inositol 2-dehydrogenase activity
CYL77_RS00940	COG1278	Cold shock
CYL77_RS00965	COG1609	Transcriptional regulator
CYL77_RS00975	COG2814	Major facilitator Superfamily
CYL77_RS00980	COG2826	transposase and inactivated derivatives, IS30 family
CYL77_RS00990	COG0069	glutamate synthase activity
CYL77_RS00990	COG0070	glutamate synthase
CYL77_RS00990	COG0067	glutamate synthase
CYL77_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
CYL77_RS01020	COG0277	FAD linked oxidase domain protein
CYL77_RS01055	COG2258	MOSC domain
CYL77_RS01060	COG1216	Glycosyl transferase, family 2
CYL77_RS01105	COG1115	amino acid carrier protein
CYL77_RS01130	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYL77_RS01130	COG0315	cyclic pyranopterin monophosphate synthase activity
CYL77_RS01135	COG0315	cyclic pyranopterin monophosphate synthase activity
CYL77_RS01150	COG0725	ABC transporter, periplasmic molybdate-binding protein
CYL77_RS01160	COG3842	ATPase activity
CYL77_RS01165	COG1950	PFAM Membrane protein of
CYL77_RS01170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYL77_RS01205	COG1231	oxidoreductase activity
CYL77_RS01210	COG2239	Acts as a magnesium transporter
CYL77_RS01215	COG0471	metal ion transport
CYL77_RS01225	COG0287	Prephenate dehydrogenase
CYL77_RS01240	COG3237	CsbD-like
CYL77_RS01255	COG2409	Drug exporters of the RND superfamily
CYL77_RS01260	COG0343	queuine tRNA-ribosyltransferase activity
CYL77_RS01280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYL77_RS01310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYL77_RS01330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYL77_RS01335	COG3442	glutamine amidotransferase
CYL77_RS01340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYL77_RS01355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYL77_RS01360	COG0697	spore germination
CYL77_RS01365	COG0527	aspartate kinase activity
CYL77_RS01370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYL77_RS01400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CYL77_RS01420	COG0798	PFAM Bile acid sodium symporter
CYL77_RS01425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYL77_RS01445	COG0651	ATP synthesis coupled electron transport
CYL77_RS01450	COG1006	Multisubunit Na H antiporter MnhC subunit
CYL77_RS01455	COG2111	Na H antiporter
CYL77_RS01455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYL77_RS01470	COG0745	RESPONSE REGULATOR receiver
CYL77_RS01475	COG5002	protein histidine kinase activity
CYL77_RS01475	COG3850	Histidine kinase
CYL77_RS01505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYL77_RS01520	COG0251	oxidation-reduction process
CYL77_RS01525	COG0477	Major facilitator Superfamily
CYL77_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
CYL77_RS01550	COG1960	acyl-CoA dehydrogenase activity
CYL77_RS01560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYL77_RS01565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYL77_RS01580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYL77_RS01645	COG1205	dead DEAH box helicase
CYL77_RS01645	COG1111	helicase
CYL77_RS01650	COG1278	Cold shock
CYL77_RS01655	COG1754	DNA topoisomerase type I activity
CYL77_RS01655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYL77_RS01695	COG0564	pseudouridine synthase activity
CYL77_RS01725	COG2814	Major facilitator Superfamily
CYL77_RS01755	COG1525	nuclease
CYL77_RS01755	COG4085	toxin activity
CYL77_RS01755	COG0737	Belongs to the 5'-nucleotidase family
CYL77_RS01765	COG1064	alcohol dehydrogenase
CYL77_RS01780	COG1088	dTDP-glucose 4,6-dehydratase activity
CYL77_RS01785	COG0778	Nitroreductase
CYL77_RS01790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYL77_RS01810	COG1505	serine-type exopeptidase activity
CYL77_RS01835	COG0489	protein tyrosine kinase activity
CYL77_RS01840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYL77_RS01850	COG1086	Polysaccharide biosynthesis protein
CYL77_RS01855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CYL77_RS01860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYL77_RS01870	COG2244	polysaccharide biosynthetic process
CYL77_RS01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYL77_RS01880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYL77_RS01885	COG1215	transferase activity, transferring glycosyl groups
CYL77_RS01900	COG2755	lipolytic protein G-D-S-L family
CYL77_RS01900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYL77_RS01925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYL77_RS01930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYL77_RS01935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CYL77_RS01940	COG3800	Transcriptional regulator
CYL77_RS01940	COG1396	sequence-specific DNA binding
CYL77_RS01950	COG1053	succinate dehydrogenase
CYL77_RS01955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CYL77_RS01975	COG2733	membrane
CYL77_RS01990	COG1309	transcriptional regulator
CYL77_RS02005	COG0788	formyltetrahydrofolate deformylase activity
CYL77_RS02010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CYL77_RS02020	COG1937	Protein conserved in bacteria
CYL77_RS02040	COG4558	Periplasmic binding protein
CYL77_RS02045	COG4139	cobalamin transport
CYL77_RS02050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CYL77_RS02080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYL77_RS02090	COG0318	PFAM AMP-dependent synthetase and ligase
CYL77_RS02105	COG5002	protein histidine kinase activity
CYL77_RS02110	COG0745	RESPONSE REGULATOR receiver
CYL77_RS02120	COG0577	efflux transmembrane transporter activity
CYL77_RS02140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYL77_RS02165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYL77_RS02170	COG0181	hydroxymethylbilane synthase activity
CYL77_RS02190	COG0477	Major facilitator Superfamily
CYL77_RS02195	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYL77_RS02195	COG1082	Xylose isomerase domain protein TIM barrel
CYL77_RS02200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYL77_RS02205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYL77_RS02210	COG0222	ribosome binding
CYL77_RS02215	COG3842	ATPase activity
CYL77_RS02235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYL77_RS02235	COG1648	precorrin-2 dehydrogenase activity
CYL77_RS02245	COG0113	porphobilinogen synthase activity
CYL77_RS02260	COG2217	Heavy metal translocating P-type atpase
CYL77_RS02265	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYL77_RS02275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYL77_RS02280	COG0406	alpha-ribazole phosphatase activity
CYL77_RS02290	COG0785	Cytochrome C biogenesis protein
CYL77_RS02295	COG1333	cytochrome c biogenesis protein
CYL77_RS02300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYL77_RS02355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYL77_RS02360	COG0583	DNA-binding transcription factor activity
CYL77_RS02400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CYL77_RS02405	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYL77_RS02410	COG3340	Belongs to the peptidase S51 family
CYL77_RS02415	COG4948	Mandelate Racemase Muconate Lactonizing
CYL77_RS02430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYL77_RS02430	COG0438	transferase activity, transferring glycosyl groups
CYL77_RS02435	COG1113	amino acid transport
CYL77_RS02440	COG2226	methyltransferase
CYL77_RS02450	COG0142	geranyltranstransferase activity
CYL77_RS02480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYL77_RS02490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYL77_RS02535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYL77_RS02550	COG0085	RNA polymerase activity
CYL77_RS02555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYL77_RS02585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYL77_RS02590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYL77_RS02600	COG1120	ATPase activity
CYL77_RS02605	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS02610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS02715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CYL77_RS02740	COG3845	ABC transporter
CYL77_RS02775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYL77_RS02785	COG1841	ribosomal large subunit assembly
CYL77_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
CYL77_RS02830	COG0574	Belongs to the PEP-utilizing enzyme family
CYL77_RS02830	COG3848	Pyruvate phosphate dikinase
CYL77_RS02845	COG1414	Transcriptional regulator
CYL77_RS02850	COG0201	protein transport
CYL77_RS02885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYL77_RS02890	COG0202	RNA polymerase activity
CYL77_RS02895	COG0203	ribosomal protein L17
CYL77_RS02900	COG0101	tRNA pseudouridine synthase activity
CYL77_RS02930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYL77_RS02940	COG1404	Belongs to the peptidase S8 family
CYL77_RS02950	COG1674	ftsk spoiiie
CYL77_RS02980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYL77_RS03005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYL77_RS03015	COG2985	domain, Protein
CYL77_RS03015	COG0569	domain protein
CYL77_RS03030	COG0456	acetyltransferase
CYL77_RS03035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYL77_RS03040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYL77_RS03040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYL77_RS03055	COG0459	protein refolding
CYL77_RS03085	COG0516	GMP reductase activity
CYL77_RS03095	COG0583	DNA-binding transcription factor activity
CYL77_RS03100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYL77_RS03100	COG0519	Catalyzes the synthesis of GMP from XMP
CYL77_RS03125	COG2197	response regulator
CYL77_RS03150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYL77_RS03165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYL77_RS03190	COG2409	Drug exporters of the RND superfamily
CYL77_RS03210	COG0702	epimerase
CYL77_RS03215	COG0415	Belongs to the DNA photolyase family
CYL77_RS03220	COG1216	Glycosyl transferase, family 2
CYL77_RS03230	COG0577	efflux transmembrane transporter activity
CYL77_RS03230	COG1136	(ABC) transporter
CYL77_RS03235	COG2011	ABC-type metal ion transport system permease component
CYL77_RS03240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CYL77_RS03245	COG1464	Belongs to the NlpA lipoprotein family
CYL77_RS03250	COG0587	DNA-directed DNA polymerase activity
CYL77_RS03275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CYL77_RS03285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYL77_RS03290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYL77_RS03315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYL77_RS03320	COG2873	o-acetylhomoserine
CYL77_RS03325	COG1966	Carbon starvation protein
CYL77_RS03335	COG2079	MmgE PrpD family protein
CYL77_RS03340	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CYL77_RS03345	COG0372	Belongs to the citrate synthase family
CYL77_RS03355	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CYL77_RS03370	COG2838	Isocitrate dehydrogenase
CYL77_RS03380	COG1120	ATPase activity
CYL77_RS03385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS03390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS03400	COG2814	Major facilitator Superfamily
CYL77_RS03410	COG2860	membrane
CYL77_RS03425	COG1120	ATPase activity
CYL77_RS03430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS03435	COG0180	Tryptophanyl-tRNA synthetase
CYL77_RS03440	COG1295	ribonuclease BN
CYL77_RS03450	COG1686	Belongs to the peptidase S11 family
CYL77_RS03460	COG0741	lytic transglycosylase activity
CYL77_RS03460	COG0791	NLP P60 protein
CYL77_RS03480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYL77_RS03485	COG1473	amidohydrolase
CYL77_RS03485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYL77_RS03495	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CYL77_RS03510	COG0523	cobalamin synthesis protein
CYL77_RS03515	COG0492	ferredoxin-NADP+ reductase activity
CYL77_RS03520	COG2079	MmgE PrpD family protein
CYL77_RS03525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CYL77_RS03530	COG0372	Belongs to the citrate synthase family
CYL77_RS03540	COG1396	sequence-specific DNA binding
CYL77_RS03540	COG3800	Transcriptional regulator
CYL77_RS03550	COG4770	biotin carboxylase activity
CYL77_RS03555	COG2897	thiosulfate sulfurtransferase activity
CYL77_RS03560	COG0189	ligase activity
CYL77_RS03575	COG0424	maF-like protein
CYL77_RS03585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYL77_RS03590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYL77_RS03610	COG3158	transport of potassium into the cell
CYL77_RS03635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL77_RS03690	COG3842	ATPase activity
CYL77_RS03720	COG0210	DNA helicase
CYL77_RS03725	COG1201	RNA secondary structure unwinding
CYL77_RS03735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYL77_RS03740	COG1316	TRANSCRIPTIONal
CYL77_RS03780	COG1482	cell wall glycoprotein biosynthetic process
CYL77_RS03810	COG0745	RESPONSE REGULATOR receiver
CYL77_RS03815	COG5002	protein histidine kinase activity
CYL77_RS03820	COG5401	PFAM Sporulation and spore germination
CYL77_RS03830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYL77_RS03835	COG0653	protein targeting
CYL77_RS03845	COG1011	Hydrolase
CYL77_RS03855	COG1162	GTPase activity
CYL77_RS03860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYL77_RS03900	COG0513	Belongs to the DEAD box helicase family
CYL77_RS03925	COG0210	DNA helicase
CYL77_RS03930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYL77_RS03935	COG2816	NAD+ diphosphatase activity
CYL77_RS03960	COG3480	Lon protease (S16) C-terminal proteolytic domain
CYL77_RS03980	COG1615	UPF0182 protein
CYL77_RS03985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYL77_RS03990	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CYL77_RS03995	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CYL77_RS04055	COG0483	inositol monophosphate 1-phosphatase activity
CYL77_RS04060	COG0483	inositol monophosphate 1-phosphatase activity
CYL77_RS04070	COG2884	Cell division ATP-binding protein ftsE
CYL77_RS04075	COG2177	Part of the ABC transporter FtsEX involved in
CYL77_RS04085	COG3189	MarR family transcriptional regulator
CYL77_RS04105	COG1132	(ABC) transporter
CYL77_RS04105	COG2375	cellular response to nickel ion
CYL77_RS04110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYL77_RS04180	COG1061	Type III restriction enzyme res subunit
CYL77_RS04195	COG1652	LysM domain
CYL77_RS04220	COG2252	PERMEase
CYL77_RS04225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYL77_RS04245	COG0372	Belongs to the citrate synthase family
CYL77_RS04250	COG0545	Peptidyl-prolyl cis-trans isomerase
CYL77_RS04265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYL77_RS04275	COG3757	hydrolase, family 25
CYL77_RS04280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYL77_RS04295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYL77_RS04315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYL77_RS04330	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYL77_RS04335	COG1201	RNA secondary structure unwinding
CYL77_RS04340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYL77_RS04345	COG3304	Inner membrane component domain
CYL77_RS04350	COG0586	Pfam SNARE associated Golgi protein
CYL77_RS04360	COG0166	Belongs to the GPI family
CYL77_RS04370	COG1605	Chorismate mutase
CYL77_RS04385	COG0577	efflux transmembrane transporter activity
CYL77_RS04385	COG1136	(ABC) transporter
CYL77_RS04395	COG0739	heme binding
CYL77_RS04410	COG0138	bifunctional purine biosynthesis protein purh
CYL77_RS04435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYL77_RS04450	COG0659	secondary active sulfate transmembrane transporter activity
CYL77_RS04470	COG0745	RESPONSE REGULATOR receiver
CYL77_RS04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYL77_RS04505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYL77_RS04510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYL77_RS04530	COG2807	transmembrane transport
CYL77_RS04550	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CYL77_RS04560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CYL77_RS04565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYL77_RS04575	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CYL77_RS04585	COG0657	acetylesterase activity
CYL77_RS04600	COG0277	FAD linked oxidase domain protein
CYL77_RS04625	COG0084	hydrolase, TatD family'
CYL77_RS04630	COG3583	domain protein
CYL77_RS04635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYL77_RS04640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYL77_RS04645	COG0488	(ABC) transporter
CYL77_RS04670	COG2326	polyphosphate kinase activity
CYL77_RS04680	COG0561	phosphatase activity
CYL77_RS04710	COG2409	Drug exporters of the RND superfamily
CYL77_RS04715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CYL77_RS04735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CYL77_RS04755	COG0411	ABC transporter
CYL77_RS04765	COG0193	aminoacyl-tRNA hydrolase activity
CYL77_RS04785	COG0193	aminoacyl-tRNA hydrolase activity
CYL77_RS04790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CYL77_RS04805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYL77_RS04810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYL77_RS04820	COG2132	Multicopper oxidase
CYL77_RS04835	COG4585	Histidine kinase
CYL77_RS04840	COG2909	trisaccharide binding
CYL77_RS04855	COG1132	(ABC) transporter
CYL77_RS04860	COG1132	(ABC) transporter
CYL77_RS04865	COG0405	Gamma-glutamyltransferase
CYL77_RS04905	COG1309	transcriptional regulator
CYL77_RS04925	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CYL77_RS04930	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CYL77_RS04935	COG0531	amino acid
CYL77_RS04945	COG3956	TIGRFAM MazG family protein
CYL77_RS04990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYL77_RS05010	COG2207	Transcriptional regulator
CYL77_RS05025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYL77_RS05035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CYL77_RS05045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYL77_RS05050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYL77_RS05105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CYL77_RS05110	COG1914	H( )-stimulated, divalent metal cation uptake system
CYL77_RS05115	COG2188	Transcriptional regulator
CYL77_RS05125	COG0114	fumarate hydratase activity
CYL77_RS05155	COG1960	acyl-CoA dehydrogenase activity
CYL77_RS05170	COG1494	fructose-1,6-bisphosphatase
CYL77_RS05200	COG1570	exodeoxyribonuclease VII activity
CYL77_RS05215	COG0628	permease
CYL77_RS05225	COG0733	neurotransmitter:sodium symporter activity
CYL77_RS05235	COG0012	GTP binding
CYL77_RS05240	COG3549	Plasmid maintenance system killer
CYL77_RS05250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYL77_RS05265	COG3547	Transposase (IS116 IS110 IS902 family)
CYL77_RS05270	COG5001	Diguanylate cyclase
CYL77_RS05270	COG3300	MHYT domain
CYL77_RS05310	COG0656	L-ascorbic acid biosynthetic process
CYL77_RS05315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYL77_RS05320	COG0702	epimerase
CYL77_RS05365	COG0406	alpha-ribazole phosphatase activity
CYL77_RS05380	COG0488	(ABC) transporter
CYL77_RS05390	COG2824	Alkylphosphonate utilization operon protein PhnA
CYL77_RS05400	COG2814	Major facilitator Superfamily
CYL77_RS05410	COG1104	cysteine desulfurase activity
CYL77_RS05420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CYL77_RS05435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CYL77_RS05440	COG2315	Protein conserved in bacteria
CYL77_RS05445	COG0095	Lipoate-protein ligase
CYL77_RS05455	COG2814	Major facilitator Superfamily
CYL77_RS05465	COG4721	ABC-type cobalt transport system, permease component
CYL77_RS05470	COG1122	ATPase activity
CYL77_RS05485	COG0387	Pfam Sodium calcium exchanger
CYL77_RS05500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYL77_RS05505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CYL77_RS05515	COG2354	Protein conserved in bacteria
CYL77_RS05520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYL77_RS05540	COG5640	endopeptidase activity
CYL77_RS05550	COG3949	Membrane
CYL77_RS05565	COG1217	gtp-binding protein TYPA
CYL77_RS05570	COG0747	negative chemotaxis
CYL77_RS05605	COG2171	N-acyltransferase activity
CYL77_RS05610	COG1113	amino acid transport
CYL77_RS05620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYL77_RS05630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYL77_RS05635	COG0463	Glycosyl transferase, family 2
CYL77_RS05660	COG0297	glycogen (starch) synthase activity
CYL77_RS05670	COG4122	O-methyltransferase activity
CYL77_RS05675	COG1595	DNA-templated transcription, initiation
CYL77_RS05720	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYL77_RS05720	COG0567	Dehydrogenase, E1 component
CYL77_RS05735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYL77_RS05740	COG2272	Belongs to the type-B carboxylesterase lipase family
CYL77_RS05760	COG2814	Major facilitator Superfamily
CYL77_RS05770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYL77_RS05805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CYL77_RS05810	COG4988	ABC transporter
CYL77_RS05815	COG1294	oxidase, subunit
CYL77_RS05820	COG1271	oxidase subunit
CYL77_RS05850	COG1309	transcriptional regulator
CYL77_RS05855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYL77_RS05860	COG1454	alcohol dehydrogenase
CYL77_RS05880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYL77_RS05885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYL77_RS05905	COG0657	acetylesterase activity
CYL77_RS05915	COG2353	YceI-like domain
CYL77_RS05920	COG1846	Transcriptional regulator
CYL77_RS05935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYL77_RS05940	COG2217	Heavy metal translocating P-type atpase
CYL77_RS05950	COG2357	RelA SpoT domain protein
CYL77_RS05965	COG0018	arginyl-trna synthetase
CYL77_RS05970	COG0019	diaminopimelate decarboxylase activity
CYL77_RS05985	COG0460	homoserine dehydrogenase
CYL77_RS05990	COG0083	homoserine kinase activity
CYL77_RS06010	COG1140	nitrate reductase beta subunit
CYL77_RS06025	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYL77_RS06025	COG0315	cyclic pyranopterin monophosphate synthase activity
CYL77_RS06035	COG1253	flavin adenine dinucleotide binding
CYL77_RS06045	COG0746	molybdenum cofactor guanylyltransferase activity
CYL77_RS06055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYL77_RS06100	COG0356	it plays a direct role in the translocation of protons across the membrane
CYL77_RS06105	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYL77_RS06110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYL77_RS06120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYL77_RS06125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYL77_RS06135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYL77_RS06145	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CYL77_RS06155	COG0346	lactoylglutathione lyase activity
CYL77_RS06170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL77_RS06175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYL77_RS06180	COG1116	anion transmembrane transporter activity
CYL77_RS06185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYL77_RS06190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYL77_RS06195	COG0366	Alpha amylase catalytic
CYL77_RS06200	COG1119	ATPase activity
CYL77_RS06225	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CYL77_RS06245	COG1396	sequence-specific DNA binding
CYL77_RS06290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYL77_RS06305	COG0154	amidase activity
CYL77_RS06320	COG0205	6-phosphofructokinase activity
CYL77_RS06325	COG1609	Transcriptional regulator
CYL77_RS06330	COG1129	ABC transporter
CYL77_RS06335	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYL77_RS06340	COG1879	ABC-type sugar transport system periplasmic component
CYL77_RS06345	COG1869	D-ribose catabolic process
CYL77_RS06360	COG0385	Bile acid
CYL77_RS06375	COG0667	Aldo Keto reductase
CYL77_RS06380	COG1279	arginine transmembrane transporter activity
CYL77_RS06385	COG0583	DNA-binding transcription factor activity
CYL77_RS06390	COG0435	Glutathione S-transferase
CYL77_RS06410	COG0129	dihydroxy-acid dehydratase activity
CYL77_RS06420	COG0668	transmembrane transport
CYL77_RS06425	COG0028	Belongs to the TPP enzyme family
CYL77_RS06430	COG0440	acetolactate synthase activity
CYL77_RS06465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYL77_RS06495	COG0473	3-isopropylmalate dehydrogenase activity
CYL77_RS06515	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYL77_RS06530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYL77_RS06535	COG3655	Transcriptional regulator
CYL77_RS06600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CYL77_RS06610	COG0058	SHG alpha-glucan phosphorylase activity
CYL77_RS06620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYL77_RS06625	COG0730	response to heat
CYL77_RS06635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYL77_RS06645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYL77_RS06650	COG0066	3-isopropylmalate dehydratase activity
CYL77_RS06655	COG0406	alpha-ribazole phosphatase activity
CYL77_RS06655	COG0494	nUDIX hydrolase
CYL77_RS06670	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYL77_RS06680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYL77_RS06685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CYL77_RS06690	COG1461	Dihydroxyacetone kinase
CYL77_RS06695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYL77_RS06705	COG0742	ribosomal rna small subunit methyltransferase
CYL77_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL77_RS06860	COG0656	L-ascorbic acid biosynthetic process
CYL77_RS06875	COG0539	negative regulation of cytoplasmic translation
CYL77_RS06880	COG1263	PTS System
CYL77_RS06880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYL77_RS06880	COG2190	(PTS) system
CYL77_RS06885	COG0237	dephospho-CoA kinase activity
CYL77_RS06910	COG0477	Major facilitator Superfamily
CYL77_RS06915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYL77_RS06945	COG1733	regulation of RNA biosynthetic process
CYL77_RS06950	COG0702	epimerase
CYL77_RS06955	COG3973	AAA domain
CYL77_RS06980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYL77_RS07005	COG4209	transmembrane transport
CYL77_RS07020	COG3842	ATPase activity
CYL77_RS07030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYL77_RS07035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYL77_RS07040	COG0072	phenylalanine-tRNA ligase activity
CYL77_RS07040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYL77_RS07060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYL77_RS07065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYL77_RS07075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYL77_RS07080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYL77_RS07090	COG0137	argininosuccinate synthase activity
CYL77_RS07095	COG0165	Argininosuccinate lyase
CYL77_RS07115	COG2835	tetraacyldisaccharide 4'-kinase activity
CYL77_RS07120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYL77_RS07160	COG0647	UMP catabolic process
CYL77_RS07175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYL77_RS07200	COG0494	nUDIX hydrolase
CYL77_RS07205	COG4974	Belongs to the 'phage' integrase family
CYL77_RS07210	COG0488	(ABC) transporter
CYL77_RS07230	COG2897	thiosulfate sulfurtransferase activity
CYL77_RS07235	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CYL77_RS07245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYL77_RS07250	COG1160	GTP binding
CYL77_RS07270	COG1132	(ABC) transporter
CYL77_RS07275	COG1132	(ABC) transporter
CYL77_RS07280	COG0428	transporter
CYL77_RS07285	COG0025	NhaP-type Na H and K H
CYL77_RS07300	COG3012	SEC-C Motif Domain Protein
CYL77_RS07310	COG0653	protein targeting
CYL77_RS07315	COG1716	ATPase activity
CYL77_RS07350	COG1253	flavin adenine dinucleotide binding
CYL77_RS07355	COG1253	flavin adenine dinucleotide binding
CYL77_RS07360	COG0513	Belongs to the DEAD box helicase family
CYL77_RS07370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYL77_RS07390	COG0842	Transport permease protein
CYL77_RS07400	COG3639	organic phosphonate transmembrane transporter activity
CYL77_RS07405	COG3639	organic phosphonate transmembrane transporter activity
CYL77_RS07410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CYL77_RS07425	COG0352	thiamine-phosphate diphosphorylase activity
CYL77_RS07425	COG0351	phosphomethylpyrimidine kinase
CYL77_RS07425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CYL77_RS07430	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CYL77_RS07435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYL77_RS07445	COG0477	Major facilitator Superfamily
CYL77_RS07450	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CYL77_RS07455	COG1971	Probably functions as a manganese efflux pump
CYL77_RS07475	COG0659	secondary active sulfate transmembrane transporter activity
CYL77_RS07505	COG0463	Glycosyl transferase, family 2
CYL77_RS07560	COG0805	protein transport
CYL77_RS07565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYL77_RS07590	COG4122	O-methyltransferase activity
CYL77_RS07605	COG1362	aminopeptidase activity
CYL77_RS07620	COG2814	Major facilitator Superfamily
CYL77_RS07625	COG1027	Aspartate ammonia-lyase
CYL77_RS07640	COG0546	phosphoglycolate phosphatase activity
CYL77_RS07645	COG0646	methionine synthase
CYL77_RS07645	COG1410	methionine synthase
CYL77_RS07655	COG2072	flavoprotein involved in K transport
CYL77_RS07665	COG0798	PFAM Bile acid sodium symporter
CYL77_RS07670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYL77_RS07675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYL77_RS07690	COG1968	undecaprenyl-diphosphatase activity
CYL77_RS07695	COG0667	Aldo Keto reductase
CYL77_RS07705	COG0167	dihydroorotate dehydrogenase activity
CYL77_RS07730	COG1881	PFAM PEBP family protein
CYL77_RS07735	COG1132	(ABC) transporter
CYL77_RS07740	COG1132	(ABC) transporter
CYL77_RS07775	COG0398	Pfam SNARE associated Golgi protein
CYL77_RS07805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYL77_RS07810	COG0791	NLP P60 protein
CYL77_RS07810	COG3883	PFAM NLP P60 protein
CYL77_RS07820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CYL77_RS07825	COG1309	transcriptional regulator
CYL77_RS07845	COG3830	Belongs to the UPF0237 family
CYL77_RS07850	COG2848	UPF0210 protein
CYL77_RS07855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYL77_RS07885	COG0488	(ABC) transporter
CYL77_RS07915	COG0822	iron-sulfur transferase activity
CYL77_RS07925	COG0396	ATPase activity
CYL77_RS07980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CYL77_RS07985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYL77_RS08020	COG2423	ornithine cyclodeaminase activity
CYL77_RS08025	COG0004	ammonium transporteR
CYL77_RS08030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYL77_RS08035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYL77_RS08040	COG0149	triose-phosphate isomerase activity
CYL77_RS08045	COG0126	phosphoglycerate kinase activity
CYL77_RS08050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYL77_RS08055	COG1481	regulation of sporulation
CYL77_RS08060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYL77_RS08070	COG0322	excinuclease ABC activity
CYL77_RS08115	COG0242	peptide deformylase activity
CYL77_RS08125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYL77_RS08135	COG1758	RNA polymerase activity
CYL77_RS08140	COG0194	GDP metabolic process
CYL77_RS08150	COG0284	orotidine-5'-phosphate decarboxylase activity
CYL77_RS08155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYL77_RS08160	COG0505	Belongs to the CarA family
CYL77_RS08165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYL77_RS08170	COG0540	Belongs to the ATCase OTCase family
CYL77_RS08175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYL77_RS08200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYL77_RS08210	COG0006	proline dipeptidase activity
CYL77_RS08215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYL77_RS08220	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYL77_RS08225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYL77_RS08240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS08250	COG1120	ATPase activity
CYL77_RS08255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYL77_RS08260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYL77_RS08265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYL77_RS08270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYL77_RS08285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYL77_RS08295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYL77_RS08320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL77_RS08330	COG1760	l-serine dehydratase
CYL77_RS08335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CYL77_RS08340	COG0124	histidyl-tRNA synthetase
CYL77_RS08350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYL77_RS08365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYL77_RS08375	COG0747	negative chemotaxis
CYL77_RS08380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYL77_RS08385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYL77_RS08400	COG0632	four-way junction helicase activity
CYL77_RS08405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYL77_RS08410	COG0217	transcriptional regulatory protein
CYL77_RS08415	COG1946	Acyl-CoA thioesterase
CYL77_RS08430	COG0438	transferase activity, transferring glycosyl groups
CYL77_RS08435	COG1560	Kdo2-lipid A biosynthetic process
CYL77_RS08440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYL77_RS08450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYL77_RS08455	COG2837	iron assimilation
CYL77_RS08460	COG2847	Copper chaperone PCu(A)C
CYL77_RS08525	COG0456	acetyltransferase
CYL77_RS08525	COG0454	-acetyltransferase
CYL77_RS08570	COG1129	ABC transporter
CYL77_RS08700	COG2453	phosphatase
CYL77_RS08700	COG0671	phosphoesterase, PA-phosphatase related
CYL77_RS08710	COG2186	Transcriptional regulator
CYL77_RS09045	COG0542	response to heat
CYL77_RS09550	COG1929	Belongs to the glycerate kinase type-1 family
CYL77_RS09580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYL77_RS09585	COG3253	May function as heme-dependent peroxidase
CYL77_RS09595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CYL77_RS09600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYL77_RS09605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYL77_RS09615	COG0756	dUTP diphosphatase activity
CYL77_RS09635	COG0483	inositol monophosphate 1-phosphatase activity
CYL77_RS09650	COG2311	Membrane
CYL77_RS09660	COG1061	Type III restriction enzyme res subunit
CYL77_RS09690	COG1321	iron dependent repressor
CYL77_RS09695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYL77_RS09715	COG0583	DNA-binding transcription factor activity
CYL77_RS09725	COG1643	Atp-dependent helicase
CYL77_RS09745	COG1349	DNA-binding transcription factor activity
CYL77_RS09755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYL77_RS09765	COG1105	Belongs to the carbohydrate kinase PfkB family
CYL77_RS09770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CYL77_RS09770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CYL77_RS09770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CYL77_RS09785	COG2233	PERMEase
CYL77_RS09790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYL77_RS09805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYL77_RS09810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYL77_RS09820	COG1196	nuclear chromosome segregation
CYL77_RS09840	COG1126	abc transporter atp-binding protein
CYL77_RS09845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL77_RS09850	COG0765	amino acid transport
CYL77_RS09855	COG0765	amino acid transport
CYL77_RS09860	COG2137	regulation of response to DNA damage stimulus
CYL77_RS09880	COG1268	BioY protein
CYL77_RS09885	COG1122	ATPase activity
CYL77_RS09895	COG1842	Phage shock protein A
CYL77_RS09900	COG1396	sequence-specific DNA binding
CYL77_RS09925	COG1674	ftsk spoiiie
CYL77_RS09935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CYL77_RS09940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYL77_RS09945	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CYL77_RS09950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYL77_RS09960	COG1185	polyribonucleotide nucleotidyltransferase activity
CYL77_RS09980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYL77_RS09990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYL77_RS10000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CYL77_RS10005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYL77_RS10010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYL77_RS10025	COG0779	Required for maturation of 30S ribosomal subunits
CYL77_RS10035	COG4166	transmembrane transport
CYL77_RS10040	COG0601	transmembrane transport
CYL77_RS10045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL77_RS10050	COG4172	Belongs to the ABC transporter superfamily
CYL77_RS10060	COG0442	prolyl-tRNA aminoacylation
CYL77_RS10065	COG3022	response to hydroperoxide
CYL77_RS10080	COG1648	precorrin-2 dehydrogenase activity
CYL77_RS10080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYL77_RS10085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CYL77_RS10135	COG2197	response regulator
CYL77_RS10140	COG3850	Histidine kinase
CYL77_RS10145	COG0577	efflux transmembrane transporter activity
CYL77_RS10150	COG0577	efflux transmembrane transporter activity
CYL77_RS10150	COG1136	(ABC) transporter
CYL77_RS10155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYL77_RS10160	COG0750	zinc metalloprotease
CYL77_RS10165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYL77_RS10180	COG1131	(ABC) transporter
CYL77_RS10185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYL77_RS10200	COG0233	cytoplasmic translational termination
CYL77_RS10210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYL77_RS10215	COG0052	Belongs to the universal ribosomal protein uS2 family
CYL77_RS10225	COG4974	Belongs to the 'phage' integrase family
CYL77_RS10235	COG0606	chelatase, subunit chli
CYL77_RS10240	COG0792	nuclease activity
CYL77_RS10250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYL77_RS10255	COG0681	Belongs to the peptidase S26 family
CYL77_RS10265	COG0335	large ribosomal subunit rRNA binding
CYL77_RS10270	COG0352	thiamine-phosphate diphosphorylase activity
CYL77_RS10275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYL77_RS10275	COG2022	thiamine diphosphate biosynthetic process
CYL77_RS10285	COG2022	thiamine diphosphate biosynthetic process
CYL77_RS10290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYL77_RS10300	COG1609	Transcriptional regulator
CYL77_RS10305	COG0471	metal ion transport
CYL77_RS10310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYL77_RS10325	COG0336	Belongs to the RNA methyltransferase TrmD family
CYL77_RS10335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYL77_RS10370	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CYL77_RS10395	COG1196	nuclear chromosome segregation
CYL77_RS10400	COG1254	Belongs to the acylphosphatase family
CYL77_RS10430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYL77_RS10435	COG0571	ribonuclease III activity
CYL77_RS10450	COG1132	(ABC) transporter
CYL77_RS10455	COG1132	(ABC) transporter
CYL77_RS10460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYL77_RS10465	COG1929	Belongs to the glycerate kinase type-1 family
CYL77_RS10495	COG0058	SHG alpha-glucan phosphorylase activity
CYL77_RS10500	COG2514	catechol 2,3-dioxygenase activity
CYL77_RS10505	COG0469	pyruvate kinase activity
CYL77_RS10515	COG0134	indole-3-glycerol-phosphate synthase activity
CYL77_RS10525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYL77_RS10535	COG0483	inositol monophosphate 1-phosphatase activity
CYL77_RS10540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYL77_RS10545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYL77_RS10565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYL77_RS10570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYL77_RS10600	COG2264	protein methyltransferase activity
CYL77_RS10610	COG0673	inositol 2-dehydrogenase activity
CYL77_RS10615	COG1609	Transcriptional regulator
CYL77_RS10620	COG1120	ATPase activity
CYL77_RS10625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL77_RS10685	COG1739	Uncharacterized protein family UPF0029
CYL77_RS10695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYL77_RS10730	COG1028	Short-chain dehydrogenase reductase Sdr
CYL77_RS10735	COG0019	diaminopimelate decarboxylase activity
CYL77_RS10755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYL77_RS10765	COG0488	(ABC) transporter
CYL77_RS10775	COG0252	asparaginase activity
CYL77_RS10785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYL77_RS10805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYL77_RS10815	COG3599	regulation of cell shape
CYL77_RS10825	COG1799	cell septum assembly
CYL77_RS10830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYL77_RS10835	COG1496	oxidoreductase activity
CYL77_RS10840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYL77_RS10845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CYL77_RS10850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYL77_RS10855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYL77_RS10865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYL77_RS10870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYL77_RS10880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYL77_RS10885	COG0768	penicillin binding
CYL77_RS10895	COG0275	rRNA processing
CYL77_RS10915	COG0456	acetyltransferase
CYL77_RS10925	COG0142	geranyltranstransferase activity
CYL77_RS10940	COG2815	serine threonine protein kinase
CYL77_RS10940	COG0515	serine threonine protein kinase
CYL77_RS10945	COG5650	phosphatidylinositol metabolic process
CYL77_RS10955	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CYL77_RS10990	COG1940	carbohydrate kinase activity
CYL77_RS10995	COG0438	transferase activity, transferring glycosyl groups
CYL77_RS11005	COG0791	NLP P60 protein
CYL77_RS11010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYL77_RS11015	COG0723	plastoquinol--plastocyanin reductase activity
CYL77_RS11020	COG2010	Cytochrome c
CYL77_RS11025	COG1845	cytochrome c oxidase, subunit III
CYL77_RS11040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYL77_RS11065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CYL77_RS11070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CYL77_RS11080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYL77_RS11085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYL77_RS11095	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYL77_RS11115	COG2985	domain, Protein
CYL77_RS11115	COG0569	domain protein
CYL77_RS11120	COG2826	transposase and inactivated derivatives, IS30 family
CYL77_RS11130	COG0174	glutamine synthetase
CYL77_RS11150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL77_RS11160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYL77_RS11190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CYL77_RS11195	COG0174	glutamine synthetase
CYL77_RS11220	COG0557	exoribonuclease II activity
CYL77_RS11240	COG3323	Protein of unknown function (DUF1653)
CYL77_RS11240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CYL77_RS11290	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CYL77_RS11320	COG0596	Alpha beta hydrolase
CYL77_RS11325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL77_RS11400	COG3387	PFAM Glycoside hydrolase 15-related
CYL77_RS11410	COG0358	DNA primase activity
CYL77_RS11425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYL77_RS11435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CYL77_RS11460	COG0423	glycine-tRNA ligase activity
CYL77_RS11485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYL77_RS11495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYL77_RS11505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYL77_RS11520	COG0484	heat shock protein binding
CYL77_RS11560	COG1132	(ABC) transporter
CYL77_RS11585	COG0366	Alpha amylase catalytic
CYL77_RS11595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CYL77_RS11620	COG1114	Component of the transport system for branched-chain amino acids
CYL77_RS11625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL77_RS11630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CYL77_RS11645	COG0277	FAD linked oxidase domain protein
CYL77_RS11645	COG0247	lactate metabolic process
CYL77_RS11670	COG0747	negative chemotaxis
CYL77_RS11675	COG0601	transmembrane transport
CYL77_RS11680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL77_RS11695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYL77_RS11705	COG0385	Bile acid
CYL77_RS11710	COG0676	glucose-6-phosphate 1-epimerase activity
CYL77_RS11715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CYL77_RS11720	COG2224	Isocitrate lyase
CYL77_RS11735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CYL77_RS11765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CYL77_RS11775	COG0481	GTPase activity
CYL77_RS11790	COG1280	lysine exporter protein (LysE YggA)
CYL77_RS11815	COG1307	EDD domain protein, DegV family
CYL77_RS11820	COG0406	alpha-ribazole phosphatase activity
CYL77_RS11830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYL77_RS11845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYL77_RS11850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYL77_RS11855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYL77_RS11890	COG1530	ribonuclease E activity
CYL77_RS11945	COG0285	dihydrofolate synthase activity
CYL77_RS11950	COG0525	valine-tRNA ligase activity
CYL77_RS11960	COG0443	Heat shock 70 kDa protein
CYL77_RS11970	COG0039	L-malate dehydrogenase activity
CYL77_RS11975	COG1309	transcriptional regulator
CYL77_RS11995	COG2814	Major facilitator Superfamily
CYL77_RS12005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYL77_RS12025	COG1414	Transcriptional regulator
CYL77_RS12030	COG0183	Belongs to the thiolase family
CYL77_RS12035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYL77_RS12050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYL77_RS12055	COG3485	protocatechuate 3,4-dioxygenase
CYL77_RS12060	COG3485	protocatechuate 3,4-dioxygenase
CYL77_RS12070	COG4829	muconolactone delta-isomerase
CYL77_RS12075	COG4948	Mandelate Racemase Muconate Lactonizing
CYL77_RS12080	COG3485	protocatechuate 3,4-dioxygenase
CYL77_RS12085	COG4638	Rieske (2fe-2S)
CYL77_RS12100	COG1028	Short-chain dehydrogenase reductase Sdr
CYL77_RS12110	COG2814	Major facilitator Superfamily
CYL77_RS12120	COG0740	serine-type endopeptidase activity
CYL77_RS12125	COG0740	serine-type endopeptidase activity
CYL77_RS12190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CYL77_RS12240	COG4172	Belongs to the ABC transporter superfamily
CYL77_RS12245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL77_RS12250	COG0601	transmembrane transport
CYL77_RS12255	COG0747	negative chemotaxis
CYL77_RS12265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYL77_RS12280	COG4221	oxidoreductase activity
CYL77_RS12295	COG1119	ATPase activity
CYL77_RS12300	COG2346	COG2346, Truncated hemoglobins
CYL77_RS12350	COG1785	Belongs to the alkaline phosphatase family
CYL77_RS12390	COG3842	ATPase activity
CYL77_RS12395	COG0463	Glycosyl transferase, family 2
CYL77_RS12420	COG1691	(AIR) carboxylase
CYL77_RS12425	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CYL77_RS12430	COG3622	Belongs to the hyi family
CYL77_RS12435	COG4221	oxidoreductase activity
CYL77_RS12440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CYL77_RS12450	COG1376	ErfK ybiS ycfS ynhG family protein
CYL77_RS12490	COG2066	Belongs to the glutaminase family
CYL77_RS12495	COG1609	Transcriptional regulator
CYL77_RS12510	COG1102	Psort location Cytoplasmic, score
CYL77_RS12510	COG1904	glucuronate isomerase
CYL77_RS12515	COG3265	gluconokinase activity
CYL77_RS12525	COG1335	isochorismatase
CYL77_RS12545	COG0736	holo-[acyl-carrier-protein] synthase activity
CYL77_RS12550	COG2814	Major facilitator Superfamily
CYL77_RS12575	COG3835	regulator
CYL77_RS12600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYL77_RS12605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYL77_RS12650	COG1234	tRNA 3'-trailer cleavage
CYL77_RS12655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CYL77_RS12675	COG3191	aminopeptidase activity
CYL77_RS12695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CYL77_RS12720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYL77_RS12735	COG2186	Transcriptional regulator
CYL77_RS12750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYL77_RS12770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYL77_RS12785	COG0604	alcohol dehydrogenase
CYL77_RS12790	COG2079	MmgE PrpD family protein
CYL77_RS12810	COG0033	Phosphoglucomutase
CYL77_RS12815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYL77_RS12820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYL77_RS12825	COG4336	lyase activity
CYL77_RS12875	COG1136	(ABC) transporter
CYL77_RS12945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYL77_RS12955	COG2197	response regulator
CYL77_RS12970	COG1045	serine acetyltransferase
CYL77_RS12995	COG0045	succinate-CoA ligase (ADP-forming) activity
CYL77_RS13010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CYL77_RS13040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYL77_RS13060	COG0456	acetyltransferase
CYL77_RS13070	COG1597	lipid kinase activity
CYL77_RS13085	COG0354	folic acid binding
CYL77_RS13095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYL77_RS13120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYL77_RS13125	COG0047	phosphoribosylformylglycinamidine synthase activity
CYL77_RS13130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYL77_RS13135	COG0386	Belongs to the glutathione peroxidase family
CYL77_RS13165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYL77_RS13170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYL77_RS13175	COG0436	Aminotransferase
CYL77_RS13180	COG0151	Belongs to the GarS family
CYL77_RS13185	COG0537	adenosine 5'-monophosphoramidase activity
CYL77_RS13195	COG3104	oligopeptide transport
CYL77_RS13200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYL77_RS13205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CYL77_RS13210	COG2205	protein histidine kinase activity
CYL77_RS13215	COG0745	RESPONSE REGULATOR receiver
CYL77_RS13220	COG0789	Transcriptional regulator
CYL77_RS13230	COG0028	Belongs to the TPP enzyme family
CYL77_RS13240	COG1309	transcriptional regulator
CYL77_RS13255	COG1053	succinate dehydrogenase
CYL77_RS13260	COG0583	DNA-binding transcription factor activity
CYL77_RS13265	COG1748	Saccharopine dehydrogenase
CYL77_RS13305	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CYL77_RS13320	COG1609	Transcriptional regulator
CYL77_RS13330	COG1121	(ABC) transporter
CYL77_RS13335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYL77_RS13350	COG1053	succinate dehydrogenase
CYL77_RS13365	COG0673	inositol 2-dehydrogenase activity
CYL77_RS13380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYL77_RS13385	COG0215	cysteine-tRNA ligase activity
CYL77_RS13395	COG1621	beta-fructofuranosidase activity
CYL77_RS13400	COG0363	glucosamine-6-phosphate deaminase activity
CYL77_RS13405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CYL77_RS13410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYL77_RS13440	COG4166	transmembrane transport
CYL77_RS13450	COG0444	Belongs to the ABC transporter superfamily
CYL77_RS13455	COG4608	Belongs to the ABC transporter superfamily
CYL77_RS13460	COG1280	lysine exporter protein (LysE YggA)
CYL77_RS13465	COG1522	sequence-specific DNA binding
CYL77_RS13475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYL77_RS13480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYL77_RS13495	COG2205	protein histidine kinase activity
CYL77_RS13500	COG2847	Copper chaperone PCu(A)C
CYL77_RS13505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYL77_RS13510	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CYL77_RS13565	COG0542	response to heat
CYL77_RS13575	COG2207	Transcriptional regulator
CYL77_RS13600	COG2814	Major facilitator Superfamily
CYL77_RS13610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYL77_RS13615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYL77_RS13635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYL77_RS13650	COG0302	gtp cyclohydrolase
CYL77_RS13655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYL77_RS13665	COG0037	tRNA processing
CYL77_RS13670	COG2027	D-alanyl-D-alanine carboxypeptidase
CYL77_RS13675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYL77_RS13680	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYL77_RS13685	COG3766	membrane
CYL77_RS13705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYL77_RS13705	COG2190	(PTS) system
CYL77_RS13705	COG1263	PTS System
CYL77_RS13710	COG2190	(PTS) system
CYL77_RS13710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYL77_RS13710	COG1263	PTS System
CYL77_RS13725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYL77_RS13740	COG1012	belongs to the aldehyde dehydrogenase family
CYL77_RS13745	COG2326	polyphosphate kinase activity
CYL77_RS13755	COG0459	protein refolding
CYL77_RS13765	COG1100	Small GTP-binding protein
CYL77_RS13815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYL77_RS13815	COG2111	Na H antiporter
CYL77_RS13820	COG1006	Multisubunit Na H antiporter MnhC subunit
CYL77_RS13825	COG0651	ATP synthesis coupled electron transport
CYL77_RS13835	COG2212	antiporter activity
CYL77_RS13840	COG1320	monovalent cation:proton antiporter activity
CYL77_RS13865	COG0242	peptide deformylase activity
CYL77_RS13880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYL77_RS13890	COG2814	Major facilitator Superfamily
CYL77_RS13910	COG1131	(ABC) transporter
CYL77_RS13930	COG0515	serine threonine protein kinase
CYL77_RS13940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CYL77_RS13945	COG0280	phosphate acetyltransferase
CYL77_RS14005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYL77_RS14015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYL77_RS14020	COG4129	membrane
CYL77_RS14025	COG0191	fructose-bisphosphate aldolase activity
CYL77_RS14040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYL77_RS14050	COG2897	thiosulfate sulfurtransferase activity
CYL77_RS14070	COG0542	response to heat
CYL77_RS14080	COG0640	Transcriptional regulator
CYL77_RS14150	COG1012	belongs to the aldehyde dehydrogenase family
CYL77_RS14155	COG0789	Transcriptional regulator
CYL77_RS14160	COG0484	heat shock protein binding
CYL77_RS14165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYL77_RS14170	COG0443	Heat shock 70 kDa protein
CYL77_RS14220	COG0730	response to heat
CYL77_RS14250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYL77_RS14300	COG1162	GTPase activity
CYL77_RS14310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYL77_RS14320	COG1122	ATPase activity
CYL77_RS14340	COG1957	nucleoside hydrolase
CYL77_RS14355	COG2818	Glycosylase
CYL77_RS14360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYL77_RS14360	COG1017	nitric oxide dioxygenase activity
CYL77_RS14370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYL77_RS14395	COG2826	transposase and inactivated derivatives, IS30 family
CYL77_RS14405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYL77_RS14430	COG1472	Belongs to the glycosyl hydrolase 3 family
CYL77_RS14445	COG4981	capsule polysaccharide biosynthetic process
CYL77_RS14470	COG0438	transferase activity, transferring glycosyl groups
CYL77_RS14480	COG0500	methyltransferase
CYL77_RS14485	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CYL77_RS14520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYL77_RS14525	COG3321	synthase
CYL77_RS14525	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CYL77_RS14525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL77_RS14530	COG0318	PFAM AMP-dependent synthetase and ligase
CYL77_RS14535	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CYL77_RS14545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CYL77_RS14545	COG5479	isomerase activity
CYL77_RS14560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYL77_RS14565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYL77_RS14570	COG0671	phosphoesterase, PA-phosphatase related
CYL77_RS14575	COG1216	Glycosyl transferase, family 2
CYL77_RS14585	COG0671	phosphoesterase, PA-phosphatase related
CYL77_RS14615	COG0561	phosphatase activity
CYL77_RS14625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYL77_RS14630	COG2188	Transcriptional regulator
CYL77_RS14650	COG0077	Prephenate dehydratase
CYL77_RS14670	COG1316	TRANSCRIPTIONal
CYL77_RS14700	COG2610	gluconate transmembrane transporter activity
CYL77_RS14705	COG0469	pyruvate kinase activity
CYL77_RS14710	COG0039	L-malate dehydrogenase activity
CYL77_RS14730	COG2188	Transcriptional regulator
CYL77_RS14735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYL77_RS14740	COG0477	Major facilitator Superfamily
CYL77_RS14770	COG1473	amidohydrolase
CYL77_RS14775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYL77_RS14790	COG0583	DNA-binding transcription factor activity
CYL77_RS14795	COG2814	Major facilitator Superfamily
CYL77_RS14825	COG2197	response regulator
CYL77_RS14845	COG3764	Sortase (surface protein transpeptidase)
CYL77_RS14850	COG0706	membrane insertase activity
CYL77_RS14875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL77_RS14885	COG0564	pseudouridine synthase activity
CYL77_RS14925	COG1842	Phage shock protein A
CYL77_RS15010	COG2217	Heavy metal translocating P-type atpase
CYL77_RS15020	COG2205	protein histidine kinase activity
CYL77_RS15025	COG0745	RESPONSE REGULATOR receiver
CYL77_RS15035	COG2132	Multicopper oxidase
CYL77_RS15045	COG1063	alcohol dehydrogenase
CYL77_RS15055	COG2608	mercury ion transmembrane transporter activity
CYL77_RS15075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYL77_RS15085	COG0477	Major facilitator Superfamily
CYL77_RS15095	COG1695	Transcriptional regulator
CYL77_RS15100	COG0305	Participates in initiation and elongation during chromosome replication
CYL77_RS15105	COG0359	binds to the 23S rRNA
CYL77_RS15110	COG0629	single-stranded DNA binding
CYL77_RS15115	COG0360	Binds together with S18 to 16S ribosomal RNA
CYL77_RS15130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYL77_RS15140	COG1846	Transcriptional regulator
CYL77_RS15160	COG1054	Belongs to the UPF0176 family
CYL77_RS15170	COG1136	(ABC) transporter
CYL77_RS15180	COG1260	myo-inositol-1-phosphate synthase
CYL77_RS15190	COG4868	Belongs to the UPF0371 family
CYL77_RS15195	COG0783	Belongs to the Dps family
CYL77_RS15200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYL77_RS15205	COG1690	Belongs to the RtcB family
CYL77_RS15215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CYL77_RS15250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYL77_RS15255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYL77_RS15275	COG0778	Nitroreductase
CYL77_RS15285	COG0495	leucyl-tRNA aminoacylation
CYL77_RS15290	COG2832	Protein of unknown function (DUF454)
CYL77_RS15305	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYL77_RS15320	COG2814	Major facilitator Superfamily
CYL77_RS15325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYL77_RS15350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYL77_RS15355	COG0512	Glutamine amidotransferase of anthranilate synthase
CYL77_RS15365	COG0134	indole-3-glycerol-phosphate synthase activity
CYL77_RS15365	COG0135	phosphoribosylanthranilate isomerase activity
CYL77_RS15370	COG0133	tryptophan synthase activity
CYL77_RS15375	COG0159	tryptophan synthase activity
CYL77_RS15385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYL77_RS15390	COG1131	(ABC) transporter
CYL77_RS15425	COG1902	pentaerythritol trinitrate reductase activity
CYL77_RS15430	COG0702	epimerase
CYL77_RS15460	COG3104	oligopeptide transport
CYL77_RS15465	COG1309	transcriptional regulator
CYL77_RS15475	COG1454	alcohol dehydrogenase
CYL77_RS15480	COG2814	Major facilitator Superfamily
CYL77_RS15485	COG1414	Transcriptional regulator
CYL77_RS15490	COG0673	inositol 2-dehydrogenase activity
CYL77_RS15500	COG0673	inositol 2-dehydrogenase activity
CYL77_RS15505	COG0673	inositol 2-dehydrogenase activity
CYL77_RS15510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYL77_RS15520	COG0477	Major facilitator Superfamily
CYL77_RS15545	COG0351	phosphomethylpyrimidine kinase
CYL77_RS15550	COG2608	mercury ion transmembrane transporter activity
CYL77_RS15560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYL77_RS15580	COG0351	phosphomethylpyrimidine kinase
CYL77_RS15590	COG2608	mercury ion transmembrane transporter activity
CYL77_RS15595	COG1687	branched-chain amino acid
CYL77_RS15600	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CYL77_RS15605	COG1678	Uncharacterized ACR, COG1678
CYL77_RS15610	COG0617	tRNA 3'-terminal CCA addition
CYL77_RS15630	COG1595	DNA-templated transcription, initiation
CYL77_RS15640	COG3118	belongs to the thioredoxin family
CYL77_RS15645	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYL77_RS15645	COG3409	Peptidoglycan-binding domain 1 protein
CYL77_RS15660	COG1192	Involved in chromosome partitioning
CYL77_RS15665	COG0357	Ribosomal RNA small subunit methyltransferase G
CYL77_RS15675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYL77_RS15680	COG0594	ribonuclease P activity