locus-tag	class	description
cgc1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
cgc1_RS00015	COG0592	DNA-directed DNA polymerase activity
cgc1_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
cgc1_RS00030	COG0187	DNA topoisomerase II activity
cgc1_RS00085	COG2855	membrane
cgc1_RS00090	COG0583	DNA-binding transcription factor activity
cgc1_RS00105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
cgc1_RS00105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
cgc1_RS00150	COG1764	response to oxidative stress
cgc1_RS00165	COG0803	Belongs to the bacterial solute-binding protein 9 family
cgc1_RS00170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
cgc1_RS00175	COG1120	ATPase activity
cgc1_RS00185	COG1172	Belongs to the binding-protein-dependent transport system permease family
cgc1_RS00190	COG1129	ABC transporter
cgc1_RS00215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cgc1_RS00220	COG1120	ATPase activity
cgc1_RS00235	COG0515	serine threonine protein kinase
cgc1_RS00235	COG2815	serine threonine protein kinase
cgc1_RS00240	COG0515	serine threonine protein kinase
cgc1_RS00245	COG0768	penicillin binding
cgc1_RS00265	COG1716	ATPase activity
cgc1_RS00300	COG0730	response to heat
cgc1_RS00305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
cgc1_RS00310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
cgc1_RS00315	COG1937	Protein conserved in bacteria
cgc1_RS00360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
cgc1_RS00370	COG2851	Citrate transporter
cgc1_RS00375	COG3290	protein histidine kinase activity
cgc1_RS00380	COG4565	transcriptional regulatory protein
cgc1_RS00385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
cgc1_RS00395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
cgc1_RS00435	COG0402	S-adenosylhomocysteine deaminase activity
cgc1_RS00450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
cgc1_RS00480	COG0832	Belongs to the urease beta subunit family
cgc1_RS00485	COG0804	urea catabolic process
cgc1_RS00490	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
cgc1_RS00495	COG0830	nickel cation binding
cgc1_RS00500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
cgc1_RS00505	COG0829	nickel cation binding
cgc1_RS00515	COG2814	Major facilitator Superfamily
cgc1_RS00525	COG0326	Molecular chaperone. Has ATPase activity
cgc1_RS00530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
cgc1_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
cgc1_RS00555	COG0667	Aldo Keto reductase
cgc1_RS00560	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
cgc1_RS00570	COG2149	membrane
cgc1_RS00595	COG0346	lactoylglutathione lyase activity
cgc1_RS00610	COG2814	Major facilitator Superfamily
cgc1_RS00620	COG1070	Carbohydrate kinase
cgc1_RS00625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
cgc1_RS00630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
cgc1_RS00635	COG3177	Filamentation induced by cAMP protein fic
cgc1_RS00660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
cgc1_RS00725	COG2860	membrane
cgc1_RS00745	COG3180	Ammonia monooxygenase
cgc1_RS00755	COG0730	response to heat
cgc1_RS00765	COG1643	Atp-dependent helicase
cgc1_RS00770	COG0110	maltose O-acetyltransferase activity
cgc1_RS00780	COG2818	Glycosylase
cgc1_RS00785	COG1280	lysine exporter protein (LysE YggA)
cgc1_RS00815	COG0251	oxidation-reduction process
cgc1_RS00825	COG3590	peptidase
cgc1_RS00840	COG2188	Transcriptional regulator
cgc1_RS00845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
cgc1_RS00860	COG3718	enzyme involved in inositol metabolism
cgc1_RS00865	COG3962	Belongs to the TPP enzyme family
cgc1_RS00875	COG0673	inositol 2-dehydrogenase activity
cgc1_RS00880	COG1082	Xylose isomerase domain protein TIM barrel
cgc1_RS00895	COG2161	toxin-antitoxin pair type II binding
cgc1_RS00910	COG0673	inositol 2-dehydrogenase activity
cgc1_RS00925	COG1278	Cold shock
cgc1_RS00950	COG1609	Transcriptional regulator
cgc1_RS00960	COG2814	Major facilitator Superfamily
cgc1_RS00970	COG0069	glutamate synthase activity
cgc1_RS00970	COG0067	glutamate synthase
cgc1_RS00970	COG0070	glutamate synthase
cgc1_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
cgc1_RS01000	COG0277	FAD linked oxidase domain protein
cgc1_RS01035	COG2258	MOSC domain
cgc1_RS01040	COG1216	Glycosyl transferase, family 2
cgc1_RS01085	COG1115	amino acid carrier protein
cgc1_RS01110	COG0315	cyclic pyranopterin monophosphate synthase activity
cgc1_RS01110	COG0521	Mo-molybdopterin cofactor biosynthetic process
cgc1_RS01115	COG0315	cyclic pyranopterin monophosphate synthase activity
cgc1_RS01130	COG0725	ABC transporter, periplasmic molybdate-binding protein
cgc1_RS01140	COG3842	ATPase activity
cgc1_RS01145	COG1950	PFAM Membrane protein of
cgc1_RS01150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
cgc1_RS01185	COG1231	oxidoreductase activity
cgc1_RS01190	COG2239	Acts as a magnesium transporter
cgc1_RS01195	COG0471	metal ion transport
cgc1_RS01205	COG0287	Prephenate dehydrogenase
cgc1_RS01220	COG3237	CsbD-like
cgc1_RS01235	COG2409	Drug exporters of the RND superfamily
cgc1_RS01240	COG0343	queuine tRNA-ribosyltransferase activity
cgc1_RS01260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
cgc1_RS01290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
cgc1_RS01310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
cgc1_RS01315	COG3442	glutamine amidotransferase
cgc1_RS01320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
cgc1_RS01335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
cgc1_RS01340	COG0697	spore germination
cgc1_RS01345	COG0527	aspartate kinase activity
cgc1_RS01350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
cgc1_RS01380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
cgc1_RS01400	COG0798	PFAM Bile acid sodium symporter
cgc1_RS01405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
cgc1_RS01425	COG0651	ATP synthesis coupled electron transport
cgc1_RS01430	COG1006	Multisubunit Na H antiporter MnhC subunit
cgc1_RS01435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
cgc1_RS01435	COG2111	Na H antiporter
cgc1_RS01450	COG0745	RESPONSE REGULATOR receiver
cgc1_RS01455	COG3850	Histidine kinase
cgc1_RS01455	COG5002	protein histidine kinase activity
cgc1_RS01485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
cgc1_RS01500	COG0251	oxidation-reduction process
cgc1_RS01505	COG0477	Major facilitator Superfamily
cgc1_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
cgc1_RS01530	COG1960	acyl-CoA dehydrogenase activity
cgc1_RS01540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
cgc1_RS01545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
cgc1_RS01560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
cgc1_RS01625	COG1111	helicase
cgc1_RS01625	COG1205	dead DEAH box helicase
cgc1_RS01630	COG1278	Cold shock
cgc1_RS01635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
cgc1_RS01635	COG1754	DNA topoisomerase type I activity
cgc1_RS01675	COG0564	pseudouridine synthase activity
cgc1_RS01705	COG2814	Major facilitator Superfamily
cgc1_RS01740	COG4085	toxin activity
cgc1_RS01740	COG1525	nuclease
cgc1_RS01740	COG0737	Belongs to the 5'-nucleotidase family
cgc1_RS01750	COG1064	alcohol dehydrogenase
cgc1_RS01765	COG1088	dTDP-glucose 4,6-dehydratase activity
cgc1_RS01770	COG0778	Nitroreductase
cgc1_RS01775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
cgc1_RS01795	COG1505	serine-type exopeptidase activity
cgc1_RS01820	COG0489	protein tyrosine kinase activity
cgc1_RS01825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
cgc1_RS01835	COG1086	Polysaccharide biosynthesis protein
cgc1_RS01840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
cgc1_RS01845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
cgc1_RS01855	COG2244	polysaccharide biosynthetic process
cgc1_RS01860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
cgc1_RS01865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
cgc1_RS01870	COG1215	transferase activity, transferring glycosyl groups
cgc1_RS01885	COG2755	lipolytic protein G-D-S-L family
cgc1_RS01885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
cgc1_RS01910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
cgc1_RS01915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
cgc1_RS01920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
cgc1_RS01925	COG3800	Transcriptional regulator
cgc1_RS01925	COG1396	sequence-specific DNA binding
cgc1_RS01935	COG1053	succinate dehydrogenase
cgc1_RS01940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
cgc1_RS01960	COG2733	membrane
cgc1_RS01975	COG1309	transcriptional regulator
cgc1_RS01990	COG0788	formyltetrahydrofolate deformylase activity
cgc1_RS01995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
cgc1_RS02005	COG1937	Protein conserved in bacteria
cgc1_RS02025	COG4558	Periplasmic binding protein
cgc1_RS02030	COG4139	cobalamin transport
cgc1_RS02035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
cgc1_RS02065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
cgc1_RS02075	COG0318	PFAM AMP-dependent synthetase and ligase
cgc1_RS02090	COG5002	protein histidine kinase activity
cgc1_RS02095	COG0745	RESPONSE REGULATOR receiver
cgc1_RS02105	COG0577	efflux transmembrane transporter activity
cgc1_RS02125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
cgc1_RS02150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
cgc1_RS02155	COG0181	hydroxymethylbilane synthase activity
cgc1_RS02175	COG0477	Major facilitator Superfamily
cgc1_RS02180	COG3185	4-Hydroxyphenylpyruvate dioxygenase
cgc1_RS02180	COG1082	Xylose isomerase domain protein TIM barrel
cgc1_RS02185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
cgc1_RS02190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
cgc1_RS02195	COG0222	ribosome binding
cgc1_RS02200	COG3842	ATPase activity
cgc1_RS02220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
cgc1_RS02220	COG1648	precorrin-2 dehydrogenase activity
cgc1_RS02230	COG0113	porphobilinogen synthase activity
cgc1_RS02245	COG2217	Heavy metal translocating P-type atpase
cgc1_RS02250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
cgc1_RS02260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
cgc1_RS02265	COG0406	alpha-ribazole phosphatase activity
cgc1_RS02275	COG0785	Cytochrome C biogenesis protein
cgc1_RS02280	COG1333	cytochrome c biogenesis protein
cgc1_RS02285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
cgc1_RS02340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
cgc1_RS02345	COG0583	DNA-binding transcription factor activity
cgc1_RS02385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
cgc1_RS02390	COG2154	pterin-4-alpha-carbinolamine dehydratase
cgc1_RS02395	COG3340	Belongs to the peptidase S51 family
cgc1_RS02400	COG4948	Mandelate Racemase Muconate Lactonizing
cgc1_RS02415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
cgc1_RS02415	COG0438	transferase activity, transferring glycosyl groups
cgc1_RS02420	COG1113	amino acid transport
cgc1_RS02425	COG2226	methyltransferase
cgc1_RS02435	COG0142	geranyltranstransferase activity
cgc1_RS02465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
cgc1_RS02475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
cgc1_RS02520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
cgc1_RS02535	COG0085	RNA polymerase activity
cgc1_RS02540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
cgc1_RS02570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
cgc1_RS02575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
cgc1_RS02585	COG1120	ATPase activity
cgc1_RS02590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cgc1_RS02595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cgc1_RS02700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
cgc1_RS02725	COG3845	ABC transporter
cgc1_RS02760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
cgc1_RS02770	COG1841	ribosomal large subunit assembly
cgc1_RS02780	COG0201	protein transport
cgc1_RS02815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
cgc1_RS02820	COG0202	RNA polymerase activity
cgc1_RS02825	COG0203	ribosomal protein L17
cgc1_RS02830	COG0101	tRNA pseudouridine synthase activity
cgc1_RS02860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
cgc1_RS02870	COG1404	Belongs to the peptidase S8 family
cgc1_RS02880	COG1674	ftsk spoiiie
cgc1_RS02910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
cgc1_RS02935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
cgc1_RS02945	COG2985	domain, Protein
cgc1_RS02945	COG0569	domain protein
cgc1_RS02960	COG0456	acetyltransferase
cgc1_RS02965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
cgc1_RS02970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
cgc1_RS02970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
cgc1_RS02985	COG0459	protein refolding
cgc1_RS03015	COG0516	GMP reductase activity
cgc1_RS03025	COG0583	DNA-binding transcription factor activity
cgc1_RS03030	COG0519	Catalyzes the synthesis of GMP from XMP
cgc1_RS03030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
cgc1_RS03035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
cgc1_RS03060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
cgc1_RS03065	COG2873	o-acetylhomoserine
cgc1_RS03070	COG1966	Carbon starvation protein
cgc1_RS03080	COG2079	MmgE PrpD family protein
cgc1_RS03085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
cgc1_RS03090	COG0372	Belongs to the citrate synthase family
cgc1_RS03100	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
cgc1_RS03115	COG2838	Isocitrate dehydrogenase
cgc1_RS03125	COG1120	ATPase activity
cgc1_RS03130	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cgc1_RS03135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cgc1_RS03145	COG2814	Major facilitator Superfamily
cgc1_RS03155	COG2860	membrane
cgc1_RS03170	COG1120	ATPase activity
cgc1_RS03175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cgc1_RS03180	COG0180	Tryptophanyl-tRNA synthetase
cgc1_RS03185	COG1295	ribonuclease BN
cgc1_RS03195	COG1686	Belongs to the peptidase S11 family
cgc1_RS03205	COG0791	NLP P60 protein
cgc1_RS03205	COG0741	lytic transglycosylase activity
cgc1_RS03225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
cgc1_RS03230	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
cgc1_RS03230	COG1473	amidohydrolase
cgc1_RS03240	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
cgc1_RS03255	COG0523	cobalamin synthesis protein
cgc1_RS03260	COG0492	ferredoxin-NADP+ reductase activity
cgc1_RS03265	COG2079	MmgE PrpD family protein
cgc1_RS03270	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
cgc1_RS03275	COG0372	Belongs to the citrate synthase family
cgc1_RS03285	COG3800	Transcriptional regulator
cgc1_RS03285	COG1396	sequence-specific DNA binding
cgc1_RS03295	COG4770	biotin carboxylase activity
cgc1_RS03300	COG2897	thiosulfate sulfurtransferase activity
cgc1_RS03305	COG0189	ligase activity
cgc1_RS03320	COG0424	maF-like protein
cgc1_RS03330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
cgc1_RS03335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
cgc1_RS03355	COG3158	transport of potassium into the cell
cgc1_RS03375	COG1316	TRANSCRIPTIONal
cgc1_RS03415	COG1482	cell wall glycoprotein biosynthetic process
cgc1_RS03445	COG0745	RESPONSE REGULATOR receiver
cgc1_RS03450	COG5002	protein histidine kinase activity
cgc1_RS03455	COG5401	PFAM Sporulation and spore germination
cgc1_RS03465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
cgc1_RS03470	COG0653	protein targeting
cgc1_RS03480	COG1011	Hydrolase
cgc1_RS03490	COG1162	GTPase activity
cgc1_RS03495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
cgc1_RS03540	COG0513	Belongs to the DEAD box helicase family
cgc1_RS03565	COG0210	DNA helicase
cgc1_RS03570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
cgc1_RS03575	COG2816	NAD+ diphosphatase activity
cgc1_RS03600	COG3480	Lon protease (S16) C-terminal proteolytic domain
cgc1_RS03620	COG1615	UPF0182 protein
cgc1_RS03625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
cgc1_RS03630	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
cgc1_RS03635	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
cgc1_RS03695	COG0483	inositol monophosphate 1-phosphatase activity
cgc1_RS03700	COG0483	inositol monophosphate 1-phosphatase activity
cgc1_RS03710	COG2884	Cell division ATP-binding protein ftsE
cgc1_RS03715	COG2177	Part of the ABC transporter FtsEX involved in
cgc1_RS03725	COG3189	MarR family transcriptional regulator
cgc1_RS03745	COG1132	(ABC) transporter
cgc1_RS03745	COG2375	cellular response to nickel ion
cgc1_RS03750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
cgc1_RS03815	COG1061	Type III restriction enzyme res subunit
cgc1_RS03830	COG1652	LysM domain
cgc1_RS03855	COG2252	PERMEase
cgc1_RS03860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
cgc1_RS03880	COG0372	Belongs to the citrate synthase family
cgc1_RS03885	COG0545	Peptidyl-prolyl cis-trans isomerase
cgc1_RS03900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
cgc1_RS03910	COG3757	hydrolase, family 25
cgc1_RS03915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
cgc1_RS03930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
cgc1_RS03950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
cgc1_RS03965	COG1218	3'(2'),5'-bisphosphate nucleotidase
cgc1_RS03970	COG1201	RNA secondary structure unwinding
cgc1_RS03975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
cgc1_RS03980	COG3304	Inner membrane component domain
cgc1_RS03985	COG0586	Pfam SNARE associated Golgi protein
cgc1_RS03995	COG0166	Belongs to the GPI family
cgc1_RS04005	COG1605	Chorismate mutase
cgc1_RS04020	COG0577	efflux transmembrane transporter activity
cgc1_RS04020	COG1136	(ABC) transporter
cgc1_RS04030	COG0739	heme binding
cgc1_RS04050	COG0138	bifunctional purine biosynthesis protein purh
cgc1_RS04075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
cgc1_RS04090	COG0659	secondary active sulfate transmembrane transporter activity
cgc1_RS04110	COG0745	RESPONSE REGULATOR receiver
cgc1_RS04120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
cgc1_RS04145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
cgc1_RS04150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
cgc1_RS04170	COG2807	transmembrane transport
cgc1_RS04190	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
cgc1_RS04205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
cgc1_RS04210	COG0084	hydrolase, TatD family'
cgc1_RS04215	COG3583	domain protein
cgc1_RS04220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
cgc1_RS04225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
cgc1_RS04230	COG0488	(ABC) transporter
cgc1_RS04255	COG2326	polyphosphate kinase activity
cgc1_RS04260	COG0561	phosphatase activity
cgc1_RS04290	COG2409	Drug exporters of the RND superfamily
cgc1_RS04295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
cgc1_RS04315	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
cgc1_RS04335	COG0411	ABC transporter
cgc1_RS04345	COG0193	aminoacyl-tRNA hydrolase activity
cgc1_RS04365	COG0193	aminoacyl-tRNA hydrolase activity
cgc1_RS04370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
cgc1_RS04385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
cgc1_RS04390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
cgc1_RS04400	COG2132	Multicopper oxidase
cgc1_RS04415	COG4585	Histidine kinase
cgc1_RS04420	COG2909	trisaccharide binding
cgc1_RS04435	COG1132	(ABC) transporter
cgc1_RS04440	COG1132	(ABC) transporter
cgc1_RS04445	COG0405	Gamma-glutamyltransferase
cgc1_RS04485	COG1309	transcriptional regulator
cgc1_RS04505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
cgc1_RS04510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
cgc1_RS04515	COG0531	amino acid
cgc1_RS04525	COG3956	TIGRFAM MazG family protein
cgc1_RS04570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
cgc1_RS04590	COG2207	Transcriptional regulator
cgc1_RS04605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
cgc1_RS04615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
cgc1_RS04625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
cgc1_RS04630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
cgc1_RS04685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
cgc1_RS04690	COG1914	H( )-stimulated, divalent metal cation uptake system
cgc1_RS04695	COG2188	Transcriptional regulator
cgc1_RS04705	COG0114	fumarate hydratase activity
cgc1_RS04735	COG1960	acyl-CoA dehydrogenase activity
cgc1_RS04750	COG1494	fructose-1,6-bisphosphatase
cgc1_RS04780	COG1570	exodeoxyribonuclease VII activity
cgc1_RS04795	COG0628	permease
cgc1_RS04805	COG0733	neurotransmitter:sodium symporter activity
cgc1_RS04815	COG0012	GTP binding
cgc1_RS04820	COG1104	cysteine desulfurase activity
cgc1_RS04830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
cgc1_RS04845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
cgc1_RS04850	COG2315	Protein conserved in bacteria
cgc1_RS04855	COG0095	Lipoate-protein ligase
cgc1_RS04865	COG2814	Major facilitator Superfamily
cgc1_RS04875	COG4721	ABC-type cobalt transport system, permease component
cgc1_RS04880	COG1122	ATPase activity
cgc1_RS04895	COG0387	Pfam Sodium calcium exchanger
cgc1_RS04910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
cgc1_RS04915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
cgc1_RS04925	COG2354	Protein conserved in bacteria
cgc1_RS04930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
cgc1_RS04950	COG5640	endopeptidase activity
cgc1_RS04960	COG3949	Membrane
cgc1_RS04975	COG1217	gtp-binding protein TYPA
cgc1_RS04980	COG0747	negative chemotaxis
cgc1_RS05015	COG2171	N-acyltransferase activity
cgc1_RS05020	COG1113	amino acid transport
cgc1_RS05030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
cgc1_RS05040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
cgc1_RS05045	COG0463	Glycosyl transferase, family 2
cgc1_RS05070	COG0297	glycogen (starch) synthase activity
cgc1_RS05080	COG4122	O-methyltransferase activity
cgc1_RS05085	COG1595	DNA-templated transcription, initiation
cgc1_RS05130	COG0567	Dehydrogenase, E1 component
cgc1_RS05130	COG0508	dehydrogenase complex catalyzes the overall conversion of
cgc1_RS05145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
cgc1_RS05150	COG2272	Belongs to the type-B carboxylesterase lipase family
cgc1_RS05170	COG2814	Major facilitator Superfamily
cgc1_RS05180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
cgc1_RS05190	COG1309	transcriptional regulator
cgc1_RS05195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
cgc1_RS05200	COG1454	alcohol dehydrogenase
cgc1_RS05220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
cgc1_RS05225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
cgc1_RS05245	COG0657	acetylesterase activity
cgc1_RS05255	COG2353	YceI-like domain
cgc1_RS05260	COG1846	Transcriptional regulator
cgc1_RS05275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
cgc1_RS05280	COG2217	Heavy metal translocating P-type atpase
cgc1_RS05290	COG2357	RelA SpoT domain protein
cgc1_RS05305	COG0018	arginyl-trna synthetase
cgc1_RS05310	COG0019	diaminopimelate decarboxylase activity
cgc1_RS05325	COG0460	homoserine dehydrogenase
cgc1_RS05330	COG0083	homoserine kinase activity
cgc1_RS05350	COG1140	nitrate reductase beta subunit
cgc1_RS05365	COG0521	Mo-molybdopterin cofactor biosynthetic process
cgc1_RS05365	COG0315	cyclic pyranopterin monophosphate synthase activity
cgc1_RS05375	COG1253	flavin adenine dinucleotide binding
cgc1_RS05385	COG0746	molybdenum cofactor guanylyltransferase activity
cgc1_RS05400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
cgc1_RS05445	COG0356	it plays a direct role in the translocation of protons across the membrane
cgc1_RS05450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
cgc1_RS05455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
cgc1_RS05465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
cgc1_RS05470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
cgc1_RS05480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
cgc1_RS05490	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
cgc1_RS05500	COG0346	lactoylglutathione lyase activity
cgc1_RS05515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
cgc1_RS05520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
cgc1_RS05525	COG1116	anion transmembrane transporter activity
cgc1_RS05530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
cgc1_RS05535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
cgc1_RS05540	COG0366	Alpha amylase catalytic
cgc1_RS05545	COG1119	ATPase activity
cgc1_RS05570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
cgc1_RS05590	COG1396	sequence-specific DNA binding
cgc1_RS05635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
cgc1_RS05650	COG0154	amidase activity
cgc1_RS05665	COG0205	6-phosphofructokinase activity
cgc1_RS05670	COG1609	Transcriptional regulator
cgc1_RS05675	COG1129	ABC transporter
cgc1_RS05680	COG1172	Belongs to the binding-protein-dependent transport system permease family
cgc1_RS05685	COG1879	ABC-type sugar transport system periplasmic component
cgc1_RS05690	COG1869	D-ribose catabolic process
cgc1_RS05705	COG0385	Bile acid
cgc1_RS05720	COG0667	Aldo Keto reductase
cgc1_RS05725	COG1279	arginine transmembrane transporter activity
cgc1_RS05730	COG0583	DNA-binding transcription factor activity
cgc1_RS05735	COG0435	Glutathione S-transferase
cgc1_RS05755	COG0129	dihydroxy-acid dehydratase activity
cgc1_RS05765	COG0668	transmembrane transport
cgc1_RS05770	COG0028	Belongs to the TPP enzyme family
cgc1_RS05775	COG0440	acetolactate synthase activity
cgc1_RS05810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
cgc1_RS05840	COG0473	3-isopropylmalate dehydrogenase activity
cgc1_RS05860	COG0179	Fumarylacetoacetate (FAA) hydrolase
cgc1_RS05875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
cgc1_RS05880	COG3655	Transcriptional regulator
cgc1_RS05945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
cgc1_RS05955	COG0058	SHG alpha-glucan phosphorylase activity
cgc1_RS05965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
cgc1_RS05970	COG0730	response to heat
cgc1_RS05980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
cgc1_RS05990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
cgc1_RS05995	COG0066	3-isopropylmalate dehydratase activity
cgc1_RS06000	COG0494	nUDIX hydrolase
cgc1_RS06000	COG0406	alpha-ribazole phosphatase activity
cgc1_RS06015	COG1181	Belongs to the D-alanine--D-alanine ligase family
cgc1_RS06025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
cgc1_RS06030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
cgc1_RS06035	COG1461	Dihydroxyacetone kinase
cgc1_RS06040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
cgc1_RS06050	COG0742	ribosomal rna small subunit methyltransferase
cgc1_RS06075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
cgc1_RS06110	COG0656	L-ascorbic acid biosynthetic process
cgc1_RS06125	COG0539	negative regulation of cytoplasmic translation
cgc1_RS06130	COG2190	(PTS) system
cgc1_RS06130	COG1263	PTS System
cgc1_RS06130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
cgc1_RS06135	COG0237	dephospho-CoA kinase activity
cgc1_RS06160	COG0477	Major facilitator Superfamily
cgc1_RS06165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
cgc1_RS06195	COG1733	regulation of RNA biosynthetic process
cgc1_RS06200	COG0702	epimerase
cgc1_RS06205	COG3973	AAA domain
cgc1_RS06230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
cgc1_RS06255	COG4209	transmembrane transport
cgc1_RS06270	COG3842	ATPase activity
cgc1_RS06280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
cgc1_RS06285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
cgc1_RS06290	COG0072	phenylalanine-tRNA ligase activity
cgc1_RS06290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
cgc1_RS06310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
cgc1_RS06315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
cgc1_RS06325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
cgc1_RS06330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
cgc1_RS06340	COG0137	argininosuccinate synthase activity
cgc1_RS06345	COG0165	Argininosuccinate lyase
cgc1_RS06365	COG2835	tetraacyldisaccharide 4'-kinase activity
cgc1_RS06370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
cgc1_RS06410	COG0647	UMP catabolic process
cgc1_RS06425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
cgc1_RS06450	COG0494	nUDIX hydrolase
cgc1_RS06455	COG4974	Belongs to the 'phage' integrase family
cgc1_RS06460	COG0488	(ABC) transporter
cgc1_RS06480	COG2897	thiosulfate sulfurtransferase activity
cgc1_RS06485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
cgc1_RS06495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
cgc1_RS06500	COG1160	GTP binding
cgc1_RS06520	COG1132	(ABC) transporter
cgc1_RS06525	COG1132	(ABC) transporter
cgc1_RS06530	COG0428	transporter
cgc1_RS06535	COG0025	NhaP-type Na H and K H
cgc1_RS06550	COG3012	SEC-C Motif Domain Protein
cgc1_RS06560	COG0653	protein targeting
cgc1_RS06565	COG1716	ATPase activity
cgc1_RS06600	COG1253	flavin adenine dinucleotide binding
cgc1_RS06605	COG1253	flavin adenine dinucleotide binding
cgc1_RS06610	COG0513	Belongs to the DEAD box helicase family
cgc1_RS06620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
cgc1_RS06640	COG0842	Transport permease protein
cgc1_RS06650	COG3639	organic phosphonate transmembrane transporter activity
cgc1_RS06655	COG3639	organic phosphonate transmembrane transporter activity
cgc1_RS06660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
cgc1_RS06675	COG0351	phosphomethylpyrimidine kinase
cgc1_RS06675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
cgc1_RS06675	COG0352	thiamine-phosphate diphosphorylase activity
cgc1_RS06680	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
cgc1_RS06685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
cgc1_RS06695	COG0477	Major facilitator Superfamily
cgc1_RS06700	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
cgc1_RS06705	COG1971	Probably functions as a manganese efflux pump
cgc1_RS06725	COG0659	secondary active sulfate transmembrane transporter activity
cgc1_RS06755	COG0463	Glycosyl transferase, family 2
cgc1_RS06810	COG0805	protein transport
cgc1_RS06815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
cgc1_RS06840	COG4122	O-methyltransferase activity
cgc1_RS06855	COG1362	aminopeptidase activity
cgc1_RS06870	COG2814	Major facilitator Superfamily
cgc1_RS06875	COG1027	Aspartate ammonia-lyase
cgc1_RS06890	COG0546	phosphoglycolate phosphatase activity
cgc1_RS06895	COG1410	methionine synthase
cgc1_RS06895	COG0646	methionine synthase
cgc1_RS06905	COG2072	flavoprotein involved in K transport
cgc1_RS06915	COG0798	PFAM Bile acid sodium symporter
cgc1_RS06920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
cgc1_RS06925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
cgc1_RS06940	COG1968	undecaprenyl-diphosphatase activity
cgc1_RS06945	COG0667	Aldo Keto reductase
cgc1_RS06955	COG0167	dihydroorotate dehydrogenase activity
cgc1_RS06980	COG1881	PFAM PEBP family protein
cgc1_RS06990	COG1132	(ABC) transporter
cgc1_RS07025	COG0398	Pfam SNARE associated Golgi protein
cgc1_RS07055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
cgc1_RS07060	COG3883	PFAM NLP P60 protein
cgc1_RS07060	COG0791	NLP P60 protein
cgc1_RS07070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
cgc1_RS07075	COG1309	transcriptional regulator
cgc1_RS07095	COG3830	Belongs to the UPF0237 family
cgc1_RS07100	COG2848	UPF0210 protein
cgc1_RS07105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
cgc1_RS07115	COG0488	(ABC) transporter
cgc1_RS07145	COG0822	iron-sulfur transferase activity
cgc1_RS07155	COG0396	ATPase activity
cgc1_RS07210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
cgc1_RS07215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
cgc1_RS07250	COG2423	ornithine cyclodeaminase activity
cgc1_RS07255	COG0004	ammonium transporteR
cgc1_RS07260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
cgc1_RS07265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
cgc1_RS07270	COG0149	triose-phosphate isomerase activity
cgc1_RS07275	COG0126	phosphoglycerate kinase activity
cgc1_RS07280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
cgc1_RS07285	COG1481	regulation of sporulation
cgc1_RS07290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
cgc1_RS07300	COG0322	excinuclease ABC activity
cgc1_RS07345	COG0242	peptide deformylase activity
cgc1_RS07355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
cgc1_RS07365	COG1758	RNA polymerase activity
cgc1_RS07370	COG0194	GDP metabolic process
cgc1_RS07380	COG0284	orotidine-5'-phosphate decarboxylase activity
cgc1_RS07385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
cgc1_RS07390	COG0505	Belongs to the CarA family
cgc1_RS07395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
cgc1_RS07400	COG0540	Belongs to the ATCase OTCase family
cgc1_RS07405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
cgc1_RS07430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
cgc1_RS07440	COG0006	proline dipeptidase activity
cgc1_RS07445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
cgc1_RS07450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
cgc1_RS07455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
cgc1_RS07470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cgc1_RS07485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
cgc1_RS07490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
cgc1_RS07495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
cgc1_RS07500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
cgc1_RS07515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
cgc1_RS07525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
cgc1_RS07550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
cgc1_RS07560	COG1760	l-serine dehydratase
cgc1_RS07565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
cgc1_RS07570	COG0124	histidyl-tRNA synthetase
cgc1_RS07580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
cgc1_RS07595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
cgc1_RS07600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
cgc1_RS07605	COG0747	negative chemotaxis
cgc1_RS07610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
cgc1_RS07615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
cgc1_RS07630	COG0632	four-way junction helicase activity
cgc1_RS07635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
cgc1_RS07640	COG0217	transcriptional regulatory protein
cgc1_RS07645	COG1946	Acyl-CoA thioesterase
cgc1_RS07660	COG0438	transferase activity, transferring glycosyl groups
cgc1_RS07665	COG1560	Kdo2-lipid A biosynthetic process
cgc1_RS07670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
cgc1_RS07680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
cgc1_RS07685	COG2837	iron assimilation
cgc1_RS07690	COG2847	Copper chaperone PCu(A)C
cgc1_RS07735	COG1929	Belongs to the glycerate kinase type-1 family
cgc1_RS07760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
cgc1_RS07765	COG3253	May function as heme-dependent peroxidase
cgc1_RS07775	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
cgc1_RS07780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
cgc1_RS07785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
cgc1_RS07795	COG0756	dUTP diphosphatase activity
cgc1_RS07815	COG0483	inositol monophosphate 1-phosphatase activity
cgc1_RS07830	COG2311	Membrane
cgc1_RS07840	COG1061	Type III restriction enzyme res subunit
cgc1_RS07870	COG1321	iron dependent repressor
cgc1_RS07875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
cgc1_RS07895	COG0583	DNA-binding transcription factor activity
cgc1_RS07905	COG1643	Atp-dependent helicase
cgc1_RS07925	COG1349	DNA-binding transcription factor activity
cgc1_RS07935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
cgc1_RS07945	COG1105	Belongs to the carbohydrate kinase PfkB family
cgc1_RS07950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
cgc1_RS07950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
cgc1_RS07950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
cgc1_RS07965	COG2233	PERMEase
cgc1_RS07970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
cgc1_RS07985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
cgc1_RS07990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
cgc1_RS08000	COG1196	nuclear chromosome segregation
cgc1_RS08020	COG1126	abc transporter atp-binding protein
cgc1_RS08025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
cgc1_RS08030	COG0765	amino acid transport
cgc1_RS08035	COG0765	amino acid transport
cgc1_RS08040	COG2137	regulation of response to DNA damage stimulus
cgc1_RS08060	COG1268	BioY protein
cgc1_RS08065	COG1122	ATPase activity
cgc1_RS08075	COG1842	Phage shock protein A
cgc1_RS08080	COG1396	sequence-specific DNA binding
cgc1_RS08105	COG1674	ftsk spoiiie
cgc1_RS08115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
cgc1_RS08120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
cgc1_RS08125	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
cgc1_RS08130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
cgc1_RS08140	COG1185	polyribonucleotide nucleotidyltransferase activity
cgc1_RS08160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
cgc1_RS08170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
cgc1_RS08180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
cgc1_RS08185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
cgc1_RS08190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
cgc1_RS08205	COG0779	Required for maturation of 30S ribosomal subunits
cgc1_RS08215	COG4166	transmembrane transport
cgc1_RS08220	COG0601	transmembrane transport
cgc1_RS08225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
cgc1_RS08230	COG4172	Belongs to the ABC transporter superfamily
cgc1_RS08235	COG0442	prolyl-tRNA aminoacylation
cgc1_RS08240	COG3022	response to hydroperoxide
cgc1_RS08255	COG1648	precorrin-2 dehydrogenase activity
cgc1_RS08255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
cgc1_RS08260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
cgc1_RS08310	COG2197	response regulator
cgc1_RS08315	COG3850	Histidine kinase
cgc1_RS08320	COG0577	efflux transmembrane transporter activity
cgc1_RS08325	COG0577	efflux transmembrane transporter activity
cgc1_RS08325	COG1136	(ABC) transporter
cgc1_RS08330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
cgc1_RS08335	COG0750	zinc metalloprotease
cgc1_RS08340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
cgc1_RS08355	COG1131	(ABC) transporter
cgc1_RS08360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
cgc1_RS08375	COG0233	cytoplasmic translational termination
cgc1_RS08385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
cgc1_RS08390	COG0052	Belongs to the universal ribosomal protein uS2 family
cgc1_RS08400	COG4974	Belongs to the 'phage' integrase family
cgc1_RS08410	COG0606	chelatase, subunit chli
cgc1_RS08415	COG0792	nuclease activity
cgc1_RS08425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
cgc1_RS08430	COG0681	Belongs to the peptidase S26 family
cgc1_RS08440	COG0335	large ribosomal subunit rRNA binding
cgc1_RS08445	COG0352	thiamine-phosphate diphosphorylase activity
cgc1_RS08450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
cgc1_RS08450	COG2022	thiamine diphosphate biosynthetic process
cgc1_RS08460	COG2022	thiamine diphosphate biosynthetic process
cgc1_RS08465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
cgc1_RS08475	COG1609	Transcriptional regulator
cgc1_RS08480	COG0471	metal ion transport
cgc1_RS08485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
cgc1_RS08500	COG0336	Belongs to the RNA methyltransferase TrmD family
cgc1_RS08510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
cgc1_RS08545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
cgc1_RS08570	COG1196	nuclear chromosome segregation
cgc1_RS08575	COG1254	Belongs to the acylphosphatase family
cgc1_RS08605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
cgc1_RS08610	COG0571	ribonuclease III activity
cgc1_RS08625	COG1132	(ABC) transporter
cgc1_RS08630	COG1132	(ABC) transporter
cgc1_RS08635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
cgc1_RS08640	COG1929	Belongs to the glycerate kinase type-1 family
cgc1_RS08670	COG0058	SHG alpha-glucan phosphorylase activity
cgc1_RS08675	COG2514	catechol 2,3-dioxygenase activity
cgc1_RS08680	COG0469	pyruvate kinase activity
cgc1_RS08690	COG0134	indole-3-glycerol-phosphate synthase activity
cgc1_RS08700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
cgc1_RS08710	COG0483	inositol monophosphate 1-phosphatase activity
cgc1_RS08715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
cgc1_RS08720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
cgc1_RS08740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
cgc1_RS08745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
cgc1_RS08775	COG2264	protein methyltransferase activity
cgc1_RS08815	COG1739	Uncharacterized protein family UPF0029
cgc1_RS08825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
cgc1_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
cgc1_RS08865	COG0019	diaminopimelate decarboxylase activity
cgc1_RS08885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
cgc1_RS08895	COG0488	(ABC) transporter
cgc1_RS08905	COG0252	asparaginase activity
cgc1_RS08915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
cgc1_RS08935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
cgc1_RS08945	COG3599	regulation of cell shape
cgc1_RS08955	COG1799	cell septum assembly
cgc1_RS08960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
cgc1_RS08965	COG1496	oxidoreductase activity
cgc1_RS08970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
cgc1_RS08975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
cgc1_RS08980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
cgc1_RS08985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
cgc1_RS08995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
cgc1_RS09000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
cgc1_RS09010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
cgc1_RS09015	COG0768	penicillin binding
cgc1_RS09025	COG0275	rRNA processing
cgc1_RS09045	COG0456	acetyltransferase
cgc1_RS09055	COG0142	geranyltranstransferase activity
cgc1_RS09070	COG2815	serine threonine protein kinase
cgc1_RS09070	COG0515	serine threonine protein kinase
cgc1_RS09075	COG5650	phosphatidylinositol metabolic process
cgc1_RS09085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
cgc1_RS09120	COG1940	carbohydrate kinase activity
cgc1_RS09125	COG0438	transferase activity, transferring glycosyl groups
cgc1_RS09135	COG0791	NLP P60 protein
cgc1_RS09140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
cgc1_RS09145	COG0723	plastoquinol--plastocyanin reductase activity
cgc1_RS09150	COG2010	Cytochrome c
cgc1_RS09155	COG1845	cytochrome c oxidase, subunit III
cgc1_RS09170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
cgc1_RS09195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
cgc1_RS09200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
cgc1_RS09210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
cgc1_RS09215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
cgc1_RS09225	COG0508	dehydrogenase complex catalyzes the overall conversion of
cgc1_RS09245	COG0569	domain protein
cgc1_RS09245	COG2985	domain, Protein
cgc1_RS09255	COG0174	glutamine synthetase
cgc1_RS09275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
cgc1_RS09285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
cgc1_RS09315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
cgc1_RS09320	COG0174	glutamine synthetase
cgc1_RS09345	COG0557	exoribonuclease II activity
cgc1_RS09370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
cgc1_RS09370	COG3323	Protein of unknown function (DUF1653)
cgc1_RS09420	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
cgc1_RS09450	COG0596	Alpha beta hydrolase
cgc1_RS09455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
cgc1_RS09535	COG3387	PFAM Glycoside hydrolase 15-related
cgc1_RS09545	COG0358	DNA primase activity
cgc1_RS09560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
cgc1_RS09570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
cgc1_RS09595	COG0423	glycine-tRNA ligase activity
cgc1_RS09620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
cgc1_RS09630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
cgc1_RS09640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
cgc1_RS09655	COG0484	heat shock protein binding
cgc1_RS09695	COG1132	(ABC) transporter
cgc1_RS09720	COG0366	Alpha amylase catalytic
cgc1_RS09730	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
cgc1_RS09755	COG1114	Component of the transport system for branched-chain amino acids
cgc1_RS09760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
cgc1_RS09765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
cgc1_RS09780	COG0277	FAD linked oxidase domain protein
cgc1_RS09780	COG0247	lactate metabolic process
cgc1_RS09805	COG0747	negative chemotaxis
cgc1_RS09810	COG0601	transmembrane transport
cgc1_RS09815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
cgc1_RS09830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
cgc1_RS09840	COG0385	Bile acid
cgc1_RS09845	COG0676	glucose-6-phosphate 1-epimerase activity
cgc1_RS09850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
cgc1_RS09855	COG2224	Isocitrate lyase
cgc1_RS09870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
cgc1_RS09900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
cgc1_RS09910	COG0481	GTPase activity
cgc1_RS09925	COG1280	lysine exporter protein (LysE YggA)
cgc1_RS09950	COG1307	EDD domain protein, DegV family
cgc1_RS09955	COG0406	alpha-ribazole phosphatase activity
cgc1_RS09965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
cgc1_RS09980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
cgc1_RS09985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
cgc1_RS09990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
cgc1_RS10025	COG1530	ribonuclease E activity
cgc1_RS10070	COG0285	dihydrofolate synthase activity
cgc1_RS10075	COG0525	valine-tRNA ligase activity
cgc1_RS10085	COG0443	Heat shock 70 kDa protein
cgc1_RS10095	COG0039	L-malate dehydrogenase activity
cgc1_RS10100	COG1309	transcriptional regulator
cgc1_RS10120	COG2814	Major facilitator Superfamily
cgc1_RS10130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
cgc1_RS10140	COG0740	serine-type endopeptidase activity
cgc1_RS10145	COG0740	serine-type endopeptidase activity
cgc1_RS10205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
cgc1_RS10220	COG1119	ATPase activity
cgc1_RS10225	COG2346	COG2346, Truncated hemoglobins
cgc1_RS10275	COG1785	Belongs to the alkaline phosphatase family
cgc1_RS10315	COG3842	ATPase activity
cgc1_RS10320	COG0463	Glycosyl transferase, family 2
cgc1_RS10345	COG1691	(AIR) carboxylase
cgc1_RS10350	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
cgc1_RS10355	COG3622	Belongs to the hyi family
cgc1_RS10360	COG4221	oxidoreductase activity
cgc1_RS10365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
cgc1_RS10375	COG1376	ErfK ybiS ycfS ynhG family protein
cgc1_RS10410	COG2066	Belongs to the glutaminase family
cgc1_RS10415	COG1609	Transcriptional regulator
cgc1_RS10430	COG1102	Psort location Cytoplasmic, score
cgc1_RS10430	COG1904	glucuronate isomerase
cgc1_RS10435	COG3265	gluconokinase activity
cgc1_RS10445	COG1335	isochorismatase
cgc1_RS10465	COG0736	holo-[acyl-carrier-protein] synthase activity
cgc1_RS10470	COG2814	Major facilitator Superfamily
cgc1_RS10495	COG3835	regulator
cgc1_RS10520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
cgc1_RS10525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
cgc1_RS10530	COG1234	tRNA 3'-trailer cleavage
cgc1_RS10535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
cgc1_RS10555	COG3191	aminopeptidase activity
cgc1_RS10575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
cgc1_RS10600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
cgc1_RS10615	COG2186	Transcriptional regulator
cgc1_RS10630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
cgc1_RS10650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
cgc1_RS10665	COG0604	alcohol dehydrogenase
cgc1_RS10670	COG2079	MmgE PrpD family protein
cgc1_RS10690	COG0033	Phosphoglucomutase
cgc1_RS10695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
cgc1_RS10700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
cgc1_RS10705	COG4336	lyase activity
cgc1_RS10750	COG1136	(ABC) transporter
cgc1_RS10820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
cgc1_RS10830	COG2197	response regulator
cgc1_RS10845	COG1045	serine acetyltransferase
cgc1_RS10870	COG0045	succinate-CoA ligase (ADP-forming) activity
cgc1_RS10885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
cgc1_RS10915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
cgc1_RS10935	COG0456	acetyltransferase
cgc1_RS10945	COG1597	lipid kinase activity
cgc1_RS10960	COG0354	folic acid binding
cgc1_RS10970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
cgc1_RS10995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
cgc1_RS11000	COG0047	phosphoribosylformylglycinamidine synthase activity
cgc1_RS11005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
cgc1_RS11010	COG0386	Belongs to the glutathione peroxidase family
cgc1_RS11040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
cgc1_RS11045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
cgc1_RS11050	COG0436	Aminotransferase
cgc1_RS11055	COG0151	Belongs to the GarS family
cgc1_RS11060	COG0537	adenosine 5'-monophosphoramidase activity
cgc1_RS11070	COG3104	oligopeptide transport
cgc1_RS11075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
cgc1_RS11080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
cgc1_RS11085	COG2205	protein histidine kinase activity
cgc1_RS11090	COG0745	RESPONSE REGULATOR receiver
cgc1_RS11095	COG0789	Transcriptional regulator
cgc1_RS11105	COG0028	Belongs to the TPP enzyme family
cgc1_RS11115	COG1309	transcriptional regulator
cgc1_RS11130	COG1053	succinate dehydrogenase
cgc1_RS11135	COG0583	DNA-binding transcription factor activity
cgc1_RS11145	COG1748	Saccharopine dehydrogenase
cgc1_RS11185	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
cgc1_RS11200	COG1609	Transcriptional regulator
cgc1_RS11210	COG1121	(ABC) transporter
cgc1_RS11215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
cgc1_RS11230	COG1053	succinate dehydrogenase
cgc1_RS11245	COG0673	inositol 2-dehydrogenase activity
cgc1_RS11260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
cgc1_RS11265	COG0215	cysteine-tRNA ligase activity
cgc1_RS11275	COG1621	beta-fructofuranosidase activity
cgc1_RS11280	COG0363	glucosamine-6-phosphate deaminase activity
cgc1_RS11285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
cgc1_RS11290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
cgc1_RS11320	COG4166	transmembrane transport
cgc1_RS11330	COG0444	Belongs to the ABC transporter superfamily
cgc1_RS11335	COG4608	Belongs to the ABC transporter superfamily
cgc1_RS11340	COG1280	lysine exporter protein (LysE YggA)
cgc1_RS11345	COG1522	sequence-specific DNA binding
cgc1_RS11355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
cgc1_RS11360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
cgc1_RS11375	COG2205	protein histidine kinase activity
cgc1_RS11380	COG2847	Copper chaperone PCu(A)C
cgc1_RS11385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
cgc1_RS11390	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
cgc1_RS11445	COG0542	response to heat
cgc1_RS11455	COG2207	Transcriptional regulator
cgc1_RS11480	COG2814	Major facilitator Superfamily
cgc1_RS11490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
cgc1_RS11495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
cgc1_RS11515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
cgc1_RS11530	COG0302	gtp cyclohydrolase
cgc1_RS11535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
cgc1_RS11545	COG0037	tRNA processing
cgc1_RS11550	COG2027	D-alanyl-D-alanine carboxypeptidase
cgc1_RS11555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
cgc1_RS11560	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
cgc1_RS11565	COG3766	membrane
cgc1_RS11585	COG2190	(PTS) system
cgc1_RS11585	COG1263	PTS System
cgc1_RS11585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
cgc1_RS11590	COG1263	PTS System
cgc1_RS11590	COG2190	(PTS) system
cgc1_RS11590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
cgc1_RS11605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
cgc1_RS11620	COG1012	belongs to the aldehyde dehydrogenase family
cgc1_RS11625	COG2326	polyphosphate kinase activity
cgc1_RS11635	COG0459	protein refolding
cgc1_RS11645	COG1100	Small GTP-binding protein
cgc1_RS11695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
cgc1_RS11695	COG2111	Na H antiporter
cgc1_RS11700	COG1006	Multisubunit Na H antiporter MnhC subunit
cgc1_RS11705	COG0651	ATP synthesis coupled electron transport
cgc1_RS11715	COG2212	antiporter activity
cgc1_RS11720	COG1320	monovalent cation:proton antiporter activity
cgc1_RS11745	COG0242	peptide deformylase activity
cgc1_RS11760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
cgc1_RS11765	COG2814	Major facilitator Superfamily
cgc1_RS11785	COG1131	(ABC) transporter
cgc1_RS11805	COG0515	serine threonine protein kinase
cgc1_RS11815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
cgc1_RS11820	COG0280	phosphate acetyltransferase
cgc1_RS11885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
cgc1_RS11895	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
cgc1_RS11900	COG4129	membrane
cgc1_RS11905	COG0191	fructose-bisphosphate aldolase activity
cgc1_RS11920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
cgc1_RS11930	COG2897	thiosulfate sulfurtransferase activity
cgc1_RS11950	COG0542	response to heat
cgc1_RS11960	COG0640	Transcriptional regulator
cgc1_RS12030	COG1012	belongs to the aldehyde dehydrogenase family
cgc1_RS12035	COG0789	Transcriptional regulator
cgc1_RS12040	COG0484	heat shock protein binding
cgc1_RS12045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
cgc1_RS12050	COG0443	Heat shock 70 kDa protein
cgc1_RS12060	COG0730	response to heat
cgc1_RS12090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
cgc1_RS12140	COG1162	GTPase activity
cgc1_RS12150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
cgc1_RS12160	COG1122	ATPase activity
cgc1_RS12180	COG1957	nucleoside hydrolase
cgc1_RS12195	COG2818	Glycosylase
cgc1_RS12200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
cgc1_RS12200	COG1017	nitric oxide dioxygenase activity
cgc1_RS12210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
cgc1_RS12240	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
cgc1_RS12265	COG1472	Belongs to the glycosyl hydrolase 3 family
cgc1_RS12280	COG4981	capsule polysaccharide biosynthetic process
cgc1_RS12305	COG0438	transferase activity, transferring glycosyl groups
cgc1_RS12315	COG0500	methyltransferase
cgc1_RS12320	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
cgc1_RS12355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
cgc1_RS12360	COG3321	synthase
cgc1_RS12360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
cgc1_RS12360	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
cgc1_RS12365	COG0318	PFAM AMP-dependent synthetase and ligase
cgc1_RS12370	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
cgc1_RS12380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
cgc1_RS12380	COG5479	isomerase activity
cgc1_RS12395	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
cgc1_RS12400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
cgc1_RS12405	COG0671	phosphoesterase, PA-phosphatase related
cgc1_RS12410	COG1216	Glycosyl transferase, family 2
cgc1_RS12420	COG0671	phosphoesterase, PA-phosphatase related
cgc1_RS12450	COG0561	phosphatase activity
cgc1_RS12460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
cgc1_RS12465	COG2188	Transcriptional regulator
cgc1_RS12485	COG0077	Prephenate dehydratase
cgc1_RS12505	COG1316	TRANSCRIPTIONal
cgc1_RS12535	COG2610	gluconate transmembrane transporter activity
cgc1_RS12540	COG0469	pyruvate kinase activity
cgc1_RS12545	COG0039	L-malate dehydrogenase activity
cgc1_RS12565	COG2188	Transcriptional regulator
cgc1_RS12570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
cgc1_RS12575	COG0477	Major facilitator Superfamily
cgc1_RS12605	COG1473	amidohydrolase
cgc1_RS12610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
cgc1_RS12620	COG0583	DNA-binding transcription factor activity
cgc1_RS12625	COG2814	Major facilitator Superfamily
cgc1_RS12655	COG2197	response regulator
cgc1_RS12675	COG3764	Sortase (surface protein transpeptidase)
cgc1_RS12680	COG0706	membrane insertase activity
cgc1_RS12705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
cgc1_RS12715	COG0564	pseudouridine synthase activity
cgc1_RS12750	COG1842	Phage shock protein A
cgc1_RS12835	COG2217	Heavy metal translocating P-type atpase
cgc1_RS12845	COG2205	protein histidine kinase activity
cgc1_RS12850	COG0745	RESPONSE REGULATOR receiver
cgc1_RS12860	COG2132	Multicopper oxidase
cgc1_RS12870	COG1063	alcohol dehydrogenase
cgc1_RS12880	COG2608	mercury ion transmembrane transporter activity
cgc1_RS12900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
cgc1_RS12910	COG0477	Major facilitator Superfamily
cgc1_RS12920	COG1695	Transcriptional regulator
cgc1_RS12925	COG0305	Participates in initiation and elongation during chromosome replication
cgc1_RS12930	COG0359	binds to the 23S rRNA
cgc1_RS12935	COG0629	single-stranded DNA binding
cgc1_RS12940	COG0360	Binds together with S18 to 16S ribosomal RNA
cgc1_RS12955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
cgc1_RS12965	COG1846	Transcriptional regulator
cgc1_RS12985	COG1054	Belongs to the UPF0176 family
cgc1_RS12995	COG1136	(ABC) transporter
cgc1_RS13005	COG1260	myo-inositol-1-phosphate synthase
cgc1_RS13015	COG4868	Belongs to the UPF0371 family
cgc1_RS13020	COG0783	Belongs to the Dps family
cgc1_RS13025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
cgc1_RS13030	COG1690	Belongs to the RtcB family
cgc1_RS13040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
cgc1_RS13075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
cgc1_RS13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
cgc1_RS13100	COG0778	Nitroreductase
cgc1_RS13110	COG0495	leucyl-tRNA aminoacylation
cgc1_RS13115	COG2832	Protein of unknown function (DUF454)
cgc1_RS13130	COG0179	Fumarylacetoacetate (FAA) hydrolase
cgc1_RS13145	COG2814	Major facilitator Superfamily
cgc1_RS13150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
cgc1_RS13175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
cgc1_RS13180	COG0512	Glutamine amidotransferase of anthranilate synthase
cgc1_RS13190	COG0135	phosphoribosylanthranilate isomerase activity
cgc1_RS13190	COG0134	indole-3-glycerol-phosphate synthase activity
cgc1_RS13195	COG0133	tryptophan synthase activity
cgc1_RS13200	COG0159	tryptophan synthase activity
cgc1_RS13210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
cgc1_RS13215	COG1131	(ABC) transporter
cgc1_RS13250	COG1902	pentaerythritol trinitrate reductase activity
cgc1_RS13255	COG0702	epimerase
cgc1_RS13285	COG3104	oligopeptide transport
cgc1_RS13290	COG1309	transcriptional regulator
cgc1_RS13300	COG1454	alcohol dehydrogenase
cgc1_RS13305	COG2814	Major facilitator Superfamily
cgc1_RS13310	COG1414	Transcriptional regulator
cgc1_RS13315	COG0673	inositol 2-dehydrogenase activity
cgc1_RS13325	COG0673	inositol 2-dehydrogenase activity
cgc1_RS13330	COG0673	inositol 2-dehydrogenase activity
cgc1_RS13335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
cgc1_RS13345	COG0477	Major facilitator Superfamily
cgc1_RS13370	COG0351	phosphomethylpyrimidine kinase
cgc1_RS13375	COG2608	mercury ion transmembrane transporter activity
cgc1_RS13385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
cgc1_RS13405	COG0351	phosphomethylpyrimidine kinase
cgc1_RS13415	COG2608	mercury ion transmembrane transporter activity
cgc1_RS13420	COG1687	branched-chain amino acid
cgc1_RS13425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
cgc1_RS13430	COG1678	Uncharacterized ACR, COG1678
cgc1_RS13435	COG0617	tRNA 3'-terminal CCA addition
cgc1_RS13455	COG1595	DNA-templated transcription, initiation
cgc1_RS13465	COG3118	belongs to the thioredoxin family
cgc1_RS13470	COG3409	Peptidoglycan-binding domain 1 protein
cgc1_RS13470	COG0860	N-Acetylmuramoyl-L-alanine amidase
cgc1_RS13485	COG1192	Involved in chromosome partitioning
cgc1_RS13490	COG0357	Ribosomal RNA small subunit methyltransferase G
cgc1_RS13500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
cgc1_RS13505	COG0594	ribonuclease P activity