locus-tag	class	description
AKL16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKL16_RS00015	COG0592	DNA-directed DNA polymerase activity
AKL16_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKL16_RS00030	COG0187	DNA topoisomerase II activity
AKL16_RS00095	COG1012	belongs to the aldehyde dehydrogenase family
AKL16_RS00110	COG2855	membrane
AKL16_RS00115	COG0583	DNA-binding transcription factor activity
AKL16_RS00130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKL16_RS00130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKL16_RS00165	COG3321	synthase
AKL16_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
AKL16_RS00165	COG0604	alcohol dehydrogenase
AKL16_RS00205	COG0297	glycogen (starch) synthase activity
AKL16_RS00210	COG0438	transferase activity, transferring glycosyl groups
AKL16_RS00215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKL16_RS00220	COG0438	transferase activity, transferring glycosyl groups
AKL16_RS00240	COG1764	response to oxidative stress
AKL16_RS00250	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKL16_RS00255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKL16_RS00260	COG1120	ATPase activity
AKL16_RS00270	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL16_RS00275	COG1129	ABC transporter
AKL16_RS00300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS00305	COG1120	ATPase activity
AKL16_RS00320	COG2815	serine threonine protein kinase
AKL16_RS00320	COG0515	serine threonine protein kinase
AKL16_RS00325	COG0515	serine threonine protein kinase
AKL16_RS00330	COG0768	penicillin binding
AKL16_RS00350	COG1716	ATPase activity
AKL16_RS00390	COG1012	belongs to the aldehyde dehydrogenase family
AKL16_RS00420	COG3971	2-oxopent-4-enoate hydratase activity
AKL16_RS00435	COG1802	Transcriptional regulator
AKL16_RS00440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKL16_RS00445	COG0477	Major facilitator Superfamily
AKL16_RS00465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKL16_RS00470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKL16_RS00475	COG1937	Protein conserved in bacteria
AKL16_RS00520	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKL16_RS00530	COG2851	Citrate transporter
AKL16_RS00535	COG3290	protein histidine kinase activity
AKL16_RS00540	COG4565	transcriptional regulatory protein
AKL16_RS00545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKL16_RS00555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKL16_RS00600	COG0402	S-adenosylhomocysteine deaminase activity
AKL16_RS00610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKL16_RS00645	COG0804	urea catabolic process
AKL16_RS00655	COG0830	nickel cation binding
AKL16_RS00660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AKL16_RS00665	COG0829	nickel cation binding
AKL16_RS00670	COG2814	Major facilitator Superfamily
AKL16_RS00680	COG0326	Molecular chaperone. Has ATPase activity
AKL16_RS00685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKL16_RS00710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKL16_RS00715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKL16_RS00730	COG1012	belongs to the aldehyde dehydrogenase family
AKL16_RS00735	COG0667	Aldo Keto reductase
AKL16_RS00740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AKL16_RS00750	COG2149	membrane
AKL16_RS00770	COG0346	lactoylglutathione lyase activity
AKL16_RS00785	COG2814	Major facilitator Superfamily
AKL16_RS00795	COG1070	Carbohydrate kinase
AKL16_RS00810	COG3177	Filamentation induced by cAMP protein fic
AKL16_RS00835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKL16_RS00870	COG2860	membrane
AKL16_RS00890	COG3180	Ammonia monooxygenase
AKL16_RS00900	COG0730	response to heat
AKL16_RS00910	COG1643	Atp-dependent helicase
AKL16_RS00915	COG0110	maltose O-acetyltransferase activity
AKL16_RS00925	COG2818	Glycosylase
AKL16_RS00930	COG1280	lysine exporter protein (LysE YggA)
AKL16_RS00960	COG0251	oxidation-reduction process
AKL16_RS00970	COG3590	peptidase
AKL16_RS00985	COG2188	Transcriptional regulator
AKL16_RS00990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL16_RS01005	COG3718	enzyme involved in inositol metabolism
AKL16_RS01010	COG3962	Belongs to the TPP enzyme family
AKL16_RS01025	COG1082	Xylose isomerase domain protein TIM barrel
AKL16_RS01060	COG0673	inositol 2-dehydrogenase activity
AKL16_RS01070	COG1278	Cold shock
AKL16_RS01085	COG3842	ATPase activity
AKL16_RS01095	COG1609	Transcriptional regulator
AKL16_RS01110	COG1609	Transcriptional regulator
AKL16_RS01120	COG2814	Major facilitator Superfamily
AKL16_RS01130	COG0070	glutamate synthase
AKL16_RS01130	COG0069	glutamate synthase activity
AKL16_RS01130	COG0067	glutamate synthase
AKL16_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
AKL16_RS01160	COG0277	FAD linked oxidase domain protein
AKL16_RS01195	COG2258	MOSC domain
AKL16_RS01200	COG1216	Glycosyl transferase, family 2
AKL16_RS01245	COG1115	amino acid carrier protein
AKL16_RS01270	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKL16_RS01270	COG0315	cyclic pyranopterin monophosphate synthase activity
AKL16_RS01290	COG0725	ABC transporter, periplasmic molybdate-binding protein
AKL16_RS01300	COG3842	ATPase activity
AKL16_RS01305	COG1950	PFAM Membrane protein of
AKL16_RS01310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKL16_RS01340	COG1231	oxidoreductase activity
AKL16_RS01345	COG2239	Acts as a magnesium transporter
AKL16_RS01350	COG0471	metal ion transport
AKL16_RS01360	COG0287	Prephenate dehydrogenase
AKL16_RS01375	COG3237	CsbD-like
AKL16_RS01390	COG2409	Drug exporters of the RND superfamily
AKL16_RS01395	COG0343	queuine tRNA-ribosyltransferase activity
AKL16_RS01415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKL16_RS01435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKL16_RS01455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKL16_RS01460	COG3442	glutamine amidotransferase
AKL16_RS01465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKL16_RS01495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKL16_RS01515	COG0527	aspartate kinase activity
AKL16_RS01550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKL16_RS01570	COG0798	PFAM Bile acid sodium symporter
AKL16_RS01575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKL16_RS01595	COG0651	ATP synthesis coupled electron transport
AKL16_RS01600	COG1006	Multisubunit Na H antiporter MnhC subunit
AKL16_RS01605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKL16_RS01605	COG2111	Na H antiporter
AKL16_RS01620	COG0745	RESPONSE REGULATOR receiver
AKL16_RS01625	COG5002	protein histidine kinase activity
AKL16_RS01625	COG3850	Histidine kinase
AKL16_RS01655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKL16_RS01670	COG0251	oxidation-reduction process
AKL16_RS01675	COG0477	Major facilitator Superfamily
AKL16_RS01685	COG1846	Transcriptional regulator
AKL16_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
AKL16_RS01700	COG1960	acyl-CoA dehydrogenase activity
AKL16_RS01710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKL16_RS01715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKL16_RS01730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKL16_RS01795	COG1205	dead DEAH box helicase
AKL16_RS01795	COG1111	helicase
AKL16_RS01800	COG1278	Cold shock
AKL16_RS01805	COG1754	DNA topoisomerase type I activity
AKL16_RS01805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKL16_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
AKL16_RS01870	COG2814	Major facilitator Superfamily
AKL16_RS01900	COG4085	toxin activity
AKL16_RS01900	COG0737	Belongs to the 5'-nucleotidase family
AKL16_RS01900	COG1525	nuclease
AKL16_RS01910	COG1064	alcohol dehydrogenase
AKL16_RS01925	COG1088	dTDP-glucose 4,6-dehydratase activity
AKL16_RS01930	COG0778	Nitroreductase
AKL16_RS01935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKL16_RS01955	COG1505	serine-type exopeptidase activity
AKL16_RS02000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKL16_RS02030	COG1134	teichoic acid transport
AKL16_RS02050	COG0438	transferase activity, transferring glycosyl groups
AKL16_RS02055	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKL16_RS02075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKL16_RS02080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKL16_RS02085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKL16_RS02095	COG1396	sequence-specific DNA binding
AKL16_RS02095	COG3800	Transcriptional regulator
AKL16_RS02105	COG1053	succinate dehydrogenase
AKL16_RS02110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKL16_RS02130	COG2733	membrane
AKL16_RS02145	COG1309	transcriptional regulator
AKL16_RS02160	COG0788	formyltetrahydrofolate deformylase activity
AKL16_RS02165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKL16_RS02175	COG1937	Protein conserved in bacteria
AKL16_RS02195	COG4558	Periplasmic binding protein
AKL16_RS02200	COG4139	cobalamin transport
AKL16_RS02205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKL16_RS02235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKL16_RS02245	COG0318	PFAM AMP-dependent synthetase and ligase
AKL16_RS02260	COG5002	protein histidine kinase activity
AKL16_RS02265	COG0745	RESPONSE REGULATOR receiver
AKL16_RS02275	COG0577	efflux transmembrane transporter activity
AKL16_RS02295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKL16_RS02320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKL16_RS02325	COG0181	hydroxymethylbilane synthase activity
AKL16_RS02345	COG0477	Major facilitator Superfamily
AKL16_RS02350	COG1082	Xylose isomerase domain protein TIM barrel
AKL16_RS02350	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AKL16_RS02355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKL16_RS02365	COG0222	ribosome binding
AKL16_RS02370	COG3842	ATPase activity
AKL16_RS02390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKL16_RS02390	COG1648	precorrin-2 dehydrogenase activity
AKL16_RS02415	COG0113	porphobilinogen synthase activity
AKL16_RS02430	COG2217	Heavy metal translocating P-type atpase
AKL16_RS02450	COG0406	alpha-ribazole phosphatase activity
AKL16_RS02460	COG0785	Cytochrome C biogenesis protein
AKL16_RS02465	COG1333	cytochrome c biogenesis protein
AKL16_RS02470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKL16_RS02530	COG0583	DNA-binding transcription factor activity
AKL16_RS02570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AKL16_RS02580	COG3340	Belongs to the peptidase S51 family
AKL16_RS02585	COG4948	Mandelate Racemase Muconate Lactonizing
AKL16_RS02600	COG0438	transferase activity, transferring glycosyl groups
AKL16_RS02600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKL16_RS02605	COG1113	amino acid transport
AKL16_RS02620	COG0142	geranyltranstransferase activity
AKL16_RS02650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKL16_RS02660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKL16_RS02725	COG0085	RNA polymerase activity
AKL16_RS02775	COG1120	ATPase activity
AKL16_RS02780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS02785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS02810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKL16_RS02900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AKL16_RS02925	COG3845	ABC transporter
AKL16_RS02960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKL16_RS02970	COG1841	ribosomal large subunit assembly
AKL16_RS03000	COG2826	transposase and inactivated derivatives, IS30 family
AKL16_RS03040	COG3848	Pyruvate phosphate dikinase
AKL16_RS03040	COG0574	Belongs to the PEP-utilizing enzyme family
AKL16_RS03055	COG1414	Transcriptional regulator
AKL16_RS03060	COG0201	protein transport
AKL16_RS03095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKL16_RS03100	COG0202	RNA polymerase activity
AKL16_RS03110	COG0101	tRNA pseudouridine synthase activity
AKL16_RS03140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AKL16_RS03150	COG1404	Belongs to the peptidase S8 family
AKL16_RS03160	COG1674	ftsk spoiiie
AKL16_RS03210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AKL16_RS03345	COG0569	domain protein
AKL16_RS03345	COG2985	domain, Protein
AKL16_RS03360	COG0456	acetyltransferase
AKL16_RS03370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AKL16_RS03370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AKL16_RS03385	COG0459	protein refolding
AKL16_RS03415	COG0516	GMP reductase activity
AKL16_RS03425	COG0583	DNA-binding transcription factor activity
AKL16_RS03430	COG0519	Catalyzes the synthesis of GMP from XMP
AKL16_RS03430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKL16_RS03455	COG2197	response regulator
AKL16_RS03480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKL16_RS03495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKL16_RS03520	COG2409	Drug exporters of the RND superfamily
AKL16_RS03540	COG0702	epimerase
AKL16_RS03545	COG0415	Belongs to the DNA photolyase family
AKL16_RS03550	COG1216	Glycosyl transferase, family 2
AKL16_RS03560	COG1136	(ABC) transporter
AKL16_RS03560	COG0577	efflux transmembrane transporter activity
AKL16_RS03565	COG2011	ABC-type metal ion transport system permease component
AKL16_RS03570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AKL16_RS03575	COG1464	Belongs to the NlpA lipoprotein family
AKL16_RS03580	COG0587	DNA-directed DNA polymerase activity
AKL16_RS03605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKL16_RS03615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKL16_RS03620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKL16_RS03645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKL16_RS03650	COG2873	o-acetylhomoserine
AKL16_RS03655	COG1966	Carbon starvation protein
AKL16_RS03665	COG2079	MmgE PrpD family protein
AKL16_RS03670	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AKL16_RS03675	COG0372	Belongs to the citrate synthase family
AKL16_RS03685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AKL16_RS03700	COG2838	Isocitrate dehydrogenase
AKL16_RS03710	COG1120	ATPase activity
AKL16_RS03715	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS03720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS03730	COG2814	Major facilitator Superfamily
AKL16_RS03740	COG2860	membrane
AKL16_RS03755	COG1120	ATPase activity
AKL16_RS03760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS03765	COG0180	Tryptophanyl-tRNA synthetase
AKL16_RS03770	COG1295	ribonuclease BN
AKL16_RS03780	COG1686	Belongs to the peptidase S11 family
AKL16_RS03790	COG0791	NLP P60 protein
AKL16_RS03790	COG0741	lytic transglycosylase activity
AKL16_RS03810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKL16_RS03815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AKL16_RS03815	COG1473	amidohydrolase
AKL16_RS03825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKL16_RS03840	COG0523	cobalamin synthesis protein
AKL16_RS03845	COG0492	ferredoxin-NADP+ reductase activity
AKL16_RS03850	COG2079	MmgE PrpD family protein
AKL16_RS03855	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AKL16_RS03860	COG0372	Belongs to the citrate synthase family
AKL16_RS03870	COG1396	sequence-specific DNA binding
AKL16_RS03870	COG3800	Transcriptional regulator
AKL16_RS03880	COG4770	biotin carboxylase activity
AKL16_RS03885	COG2897	thiosulfate sulfurtransferase activity
AKL16_RS03890	COG0189	ligase activity
AKL16_RS03915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKL16_RS03920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKL16_RS03965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL16_RS04015	COG3842	ATPase activity
AKL16_RS04030	COG1316	TRANSCRIPTIONal
AKL16_RS04080	COG1482	cell wall glycoprotein biosynthetic process
AKL16_RS04110	COG0745	RESPONSE REGULATOR receiver
AKL16_RS04115	COG5002	protein histidine kinase activity
AKL16_RS04120	COG5401	PFAM Sporulation and spore germination
AKL16_RS04130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKL16_RS04145	COG1011	Hydrolase
AKL16_RS04155	COG1162	GTPase activity
AKL16_RS04160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKL16_RS04200	COG0513	Belongs to the DEAD box helicase family
AKL16_RS04225	COG0210	DNA helicase
AKL16_RS04230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKL16_RS04235	COG2816	NAD+ diphosphatase activity
AKL16_RS04260	COG3480	Lon protease (S16) C-terminal proteolytic domain
AKL16_RS04280	COG1615	UPF0182 protein
AKL16_RS04285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKL16_RS04290	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AKL16_RS04295	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AKL16_RS04360	COG0483	inositol monophosphate 1-phosphatase activity
AKL16_RS04365	COG0483	inositol monophosphate 1-phosphatase activity
AKL16_RS04375	COG2884	Cell division ATP-binding protein ftsE
AKL16_RS04380	COG2177	Part of the ABC transporter FtsEX involved in
AKL16_RS04390	COG3189	MarR family transcriptional regulator
AKL16_RS04405	COG2375	cellular response to nickel ion
AKL16_RS04405	COG1132	(ABC) transporter
AKL16_RS04410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKL16_RS04475	COG1061	Type III restriction enzyme res subunit
AKL16_RS04490	COG1652	LysM domain
AKL16_RS04515	COG2252	PERMEase
AKL16_RS04520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKL16_RS04540	COG0372	Belongs to the citrate synthase family
AKL16_RS04545	COG0545	Peptidyl-prolyl cis-trans isomerase
AKL16_RS04560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKL16_RS04570	COG3757	hydrolase, family 25
AKL16_RS04575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKL16_RS04590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKL16_RS04610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AKL16_RS04625	COG1218	3'(2'),5'-bisphosphate nucleotidase
AKL16_RS04630	COG1201	RNA secondary structure unwinding
AKL16_RS04635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKL16_RS04640	COG3304	Inner membrane component domain
AKL16_RS04645	COG0586	Pfam SNARE associated Golgi protein
AKL16_RS04655	COG0166	Belongs to the GPI family
AKL16_RS04665	COG1605	Chorismate mutase
AKL16_RS04680	COG0577	efflux transmembrane transporter activity
AKL16_RS04680	COG1136	(ABC) transporter
AKL16_RS04690	COG0739	heme binding
AKL16_RS04705	COG0138	bifunctional purine biosynthesis protein purh
AKL16_RS04715	COG1309	transcriptional regulator
AKL16_RS04730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKL16_RS04745	COG0659	secondary active sulfate transmembrane transporter activity
AKL16_RS04765	COG0745	RESPONSE REGULATOR receiver
AKL16_RS04775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKL16_RS04800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKL16_RS04805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKL16_RS04825	COG2807	transmembrane transport
AKL16_RS04845	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
AKL16_RS04855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKL16_RS04860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKL16_RS04870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AKL16_RS04885	COG0657	acetylesterase activity
AKL16_RS04900	COG0277	FAD linked oxidase domain protein
AKL16_RS04925	COG0084	hydrolase, TatD family'
AKL16_RS04930	COG3583	domain protein
AKL16_RS04945	COG0488	(ABC) transporter
AKL16_RS04970	COG2326	polyphosphate kinase activity
AKL16_RS04975	COG0561	phosphatase activity
AKL16_RS04995	COG5479	isomerase activity
AKL16_RS04995	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AKL16_RS05005	COG2409	Drug exporters of the RND superfamily
AKL16_RS05010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKL16_RS05030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AKL16_RS05050	COG0411	ABC transporter
AKL16_RS05060	COG0193	aminoacyl-tRNA hydrolase activity
AKL16_RS05080	COG0193	aminoacyl-tRNA hydrolase activity
AKL16_RS05085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKL16_RS05100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKL16_RS05105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKL16_RS05115	COG2132	Multicopper oxidase
AKL16_RS05120	COG1131	(ABC) transporter
AKL16_RS05130	COG4585	Histidine kinase
AKL16_RS05135	COG2201	protein-glutamate methylesterase activity
AKL16_RS05150	COG1132	(ABC) transporter
AKL16_RS05155	COG1132	(ABC) transporter
AKL16_RS05160	COG0405	Gamma-glutamyltransferase
AKL16_RS05175	COG1309	transcriptional regulator
AKL16_RS05195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AKL16_RS05200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AKL16_RS05205	COG0531	amino acid
AKL16_RS05215	COG3956	TIGRFAM MazG family protein
AKL16_RS05265	COG2207	Transcriptional regulator
AKL16_RS05290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKL16_RS05300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKL16_RS05310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKL16_RS05315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKL16_RS05385	COG1914	H( )-stimulated, divalent metal cation uptake system
AKL16_RS05390	COG2188	Transcriptional regulator
AKL16_RS05400	COG0114	fumarate hydratase activity
AKL16_RS05430	COG1960	acyl-CoA dehydrogenase activity
AKL16_RS05445	COG1494	fructose-1,6-bisphosphatase
AKL16_RS05460	COG2814	Major facilitator Superfamily
AKL16_RS05475	COG1570	exodeoxyribonuclease VII activity
AKL16_RS05490	COG0628	permease
AKL16_RS05500	COG0733	neurotransmitter:sodium symporter activity
AKL16_RS05510	COG0012	GTP binding
AKL16_RS05525	COG0745	RESPONSE REGULATOR receiver
AKL16_RS05555	COG2801	Transposase and inactivated derivatives
AKL16_RS05585	COG2814	Major facilitator Superfamily
AKL16_RS05605	COG0702	epimerase
AKL16_RS05665	COG0488	(ABC) transporter
AKL16_RS05675	COG2824	Alkylphosphonate utilization operon protein PhnA
AKL16_RS05685	COG2814	Major facilitator Superfamily
AKL16_RS05690	COG1104	cysteine desulfurase activity
AKL16_RS05700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKL16_RS05715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKL16_RS05720	COG2315	Protein conserved in bacteria
AKL16_RS05725	COG0095	Lipoate-protein ligase
AKL16_RS05735	COG2814	Major facilitator Superfamily
AKL16_RS05745	COG4721	ABC-type cobalt transport system, permease component
AKL16_RS05750	COG1122	ATPase activity
AKL16_RS05765	COG0387	Pfam Sodium calcium exchanger
AKL16_RS05780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKL16_RS05785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AKL16_RS05795	COG2354	Protein conserved in bacteria
AKL16_RS05800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKL16_RS05820	COG5640	endopeptidase activity
AKL16_RS05830	COG3949	Membrane
AKL16_RS05845	COG1217	gtp-binding protein TYPA
AKL16_RS05850	COG0747	negative chemotaxis
AKL16_RS05885	COG2171	N-acyltransferase activity
AKL16_RS05890	COG1113	amino acid transport
AKL16_RS05900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKL16_RS05910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKL16_RS05915	COG0463	Glycosyl transferase, family 2
AKL16_RS05940	COG0297	glycogen (starch) synthase activity
AKL16_RS05950	COG4122	O-methyltransferase activity
AKL16_RS05955	COG1595	DNA-templated transcription, initiation
AKL16_RS06000	COG0567	Dehydrogenase, E1 component
AKL16_RS06000	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL16_RS06015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKL16_RS06020	COG2272	Belongs to the type-B carboxylesterase lipase family
AKL16_RS06040	COG2814	Major facilitator Superfamily
AKL16_RS06085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKL16_RS06090	COG4988	ABC transporter
AKL16_RS06095	COG1294	oxidase, subunit
AKL16_RS06100	COG1271	oxidase subunit
AKL16_RS06160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKL16_RS06165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKL16_RS06185	COG0657	acetylesterase activity
AKL16_RS06195	COG2353	YceI-like domain
AKL16_RS06200	COG1846	Transcriptional regulator
AKL16_RS06215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKL16_RS06220	COG2217	Heavy metal translocating P-type atpase
AKL16_RS06230	COG2357	RelA SpoT domain protein
AKL16_RS06250	COG0019	diaminopimelate decarboxylase activity
AKL16_RS06265	COG0460	homoserine dehydrogenase
AKL16_RS06270	COG0083	homoserine kinase activity
AKL16_RS06290	COG1140	nitrate reductase beta subunit
AKL16_RS06305	COG0315	cyclic pyranopterin monophosphate synthase activity
AKL16_RS06305	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKL16_RS06315	COG1253	flavin adenine dinucleotide binding
AKL16_RS06325	COG0746	molybdenum cofactor guanylyltransferase activity
AKL16_RS06335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AKL16_RS06380	COG0356	it plays a direct role in the translocation of protons across the membrane
AKL16_RS06385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKL16_RS06390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKL16_RS06400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKL16_RS06405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKL16_RS06415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKL16_RS06435	COG0346	lactoylglutathione lyase activity
AKL16_RS06450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL16_RS06455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKL16_RS06460	COG1116	anion transmembrane transporter activity
AKL16_RS06465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKL16_RS06470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKL16_RS06475	COG0366	Alpha amylase catalytic
AKL16_RS06480	COG1119	ATPase activity
AKL16_RS06505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AKL16_RS06510	COG1104	cysteine desulfurase activity
AKL16_RS06525	COG1396	sequence-specific DNA binding
AKL16_RS06585	COG0154	amidase activity
AKL16_RS06600	COG0205	6-phosphofructokinase activity
AKL16_RS06605	COG1609	Transcriptional regulator
AKL16_RS06615	COG1869	D-ribose catabolic process
AKL16_RS06630	COG0385	Bile acid
AKL16_RS06645	COG0667	Aldo Keto reductase
AKL16_RS06650	COG1279	arginine transmembrane transporter activity
AKL16_RS06655	COG0583	DNA-binding transcription factor activity
AKL16_RS06660	COG0435	Glutathione S-transferase
AKL16_RS06680	COG0129	dihydroxy-acid dehydratase activity
AKL16_RS06690	COG0668	transmembrane transport
AKL16_RS06695	COG0028	Belongs to the TPP enzyme family
AKL16_RS06700	COG0440	acetolactate synthase activity
AKL16_RS06710	COG1116	anion transmembrane transporter activity
AKL16_RS06740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKL16_RS06770	COG0473	3-isopropylmalate dehydrogenase activity
AKL16_RS06790	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKL16_RS06805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKL16_RS06810	COG3655	Transcriptional regulator
AKL16_RS06875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKL16_RS06890	COG0058	SHG alpha-glucan phosphorylase activity
AKL16_RS06900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKL16_RS06905	COG0730	response to heat
AKL16_RS06915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKL16_RS06925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKL16_RS06930	COG0066	3-isopropylmalate dehydratase activity
AKL16_RS06935	COG0494	nUDIX hydrolase
AKL16_RS06935	COG0406	alpha-ribazole phosphatase activity
AKL16_RS06960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKL16_RS06965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKL16_RS06970	COG1461	Dihydroxyacetone kinase
AKL16_RS06975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKL16_RS06985	COG0742	ribosomal rna small subunit methyltransferase
AKL16_RS07010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKL16_RS07045	COG0656	L-ascorbic acid biosynthetic process
AKL16_RS07060	COG0539	negative regulation of cytoplasmic translation
AKL16_RS07065	COG2190	(PTS) system
AKL16_RS07065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKL16_RS07065	COG1263	PTS System
AKL16_RS07070	COG0237	dephospho-CoA kinase activity
AKL16_RS07095	COG0477	Major facilitator Superfamily
AKL16_RS07100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL16_RS07130	COG1733	regulation of RNA biosynthetic process
AKL16_RS07135	COG0702	epimerase
AKL16_RS07140	COG3973	AAA domain
AKL16_RS07190	COG4209	transmembrane transport
AKL16_RS07205	COG3842	ATPase activity
AKL16_RS07215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKL16_RS07220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKL16_RS07225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKL16_RS07225	COG0072	phenylalanine-tRNA ligase activity
AKL16_RS07245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKL16_RS07260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKL16_RS07265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKL16_RS07275	COG0137	argininosuccinate synthase activity
AKL16_RS07300	COG2835	tetraacyldisaccharide 4'-kinase activity
AKL16_RS07305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKL16_RS07350	COG0647	UMP catabolic process
AKL16_RS07365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKL16_RS07390	COG0494	nUDIX hydrolase
AKL16_RS07395	COG4974	Belongs to the 'phage' integrase family
AKL16_RS07400	COG0488	(ABC) transporter
AKL16_RS07420	COG2897	thiosulfate sulfurtransferase activity
AKL16_RS07425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKL16_RS07435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKL16_RS07440	COG1160	GTP binding
AKL16_RS07445	COG2826	transposase and inactivated derivatives, IS30 family
AKL16_RS07470	COG1132	(ABC) transporter
AKL16_RS07475	COG0428	transporter
AKL16_RS07480	COG0025	NhaP-type Na H and K H
AKL16_RS07495	COG3012	SEC-C Motif Domain Protein
AKL16_RS07505	COG0653	protein targeting
AKL16_RS07510	COG1716	ATPase activity
AKL16_RS07545	COG1253	flavin adenine dinucleotide binding
AKL16_RS07550	COG1253	flavin adenine dinucleotide binding
AKL16_RS07555	COG0513	Belongs to the DEAD box helicase family
AKL16_RS07565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKL16_RS07585	COG0842	Transport permease protein
AKL16_RS07595	COG3639	organic phosphonate transmembrane transporter activity
AKL16_RS07600	COG3639	organic phosphonate transmembrane transporter activity
AKL16_RS07605	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AKL16_RS07620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKL16_RS07620	COG0351	phosphomethylpyrimidine kinase
AKL16_RS07620	COG0352	thiamine-phosphate diphosphorylase activity
AKL16_RS07625	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AKL16_RS07630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKL16_RS07640	COG0477	Major facilitator Superfamily
AKL16_RS07645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AKL16_RS07670	COG0659	secondary active sulfate transmembrane transporter activity
AKL16_RS07700	COG0463	Glycosyl transferase, family 2
AKL16_RS07755	COG0805	protein transport
AKL16_RS07760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKL16_RS07785	COG4122	O-methyltransferase activity
AKL16_RS07800	COG1362	aminopeptidase activity
AKL16_RS07815	COG2814	Major facilitator Superfamily
AKL16_RS07820	COG1027	Aspartate ammonia-lyase
AKL16_RS07835	COG0546	phosphoglycolate phosphatase activity
AKL16_RS07840	COG1410	methionine synthase
AKL16_RS07840	COG0646	methionine synthase
AKL16_RS07850	COG2072	flavoprotein involved in K transport
AKL16_RS07860	COG0798	PFAM Bile acid sodium symporter
AKL16_RS07865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKL16_RS07870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKL16_RS07885	COG1968	undecaprenyl-diphosphatase activity
AKL16_RS07890	COG0667	Aldo Keto reductase
AKL16_RS07915	COG1881	PFAM PEBP family protein
AKL16_RS07920	COG1132	(ABC) transporter
AKL16_RS07925	COG1132	(ABC) transporter
AKL16_RS08000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKL16_RS08005	COG0791	NLP P60 protein
AKL16_RS08005	COG3883	PFAM NLP P60 protein
AKL16_RS08015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKL16_RS08020	COG1309	transcriptional regulator
AKL16_RS08040	COG3830	Belongs to the UPF0237 family
AKL16_RS08045	COG2848	UPF0210 protein
AKL16_RS08050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKL16_RS08070	COG0488	(ABC) transporter
AKL16_RS08115	COG0822	iron-sulfur transferase activity
AKL16_RS08125	COG0396	ATPase activity
AKL16_RS08180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKL16_RS08185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKL16_RS08210	COG2423	ornithine cyclodeaminase activity
AKL16_RS08215	COG0004	ammonium transporteR
AKL16_RS08225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKL16_RS08230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKL16_RS08235	COG0149	triose-phosphate isomerase activity
AKL16_RS08245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKL16_RS08250	COG1481	regulation of sporulation
AKL16_RS08265	COG0322	excinuclease ABC activity
AKL16_RS08310	COG0242	peptide deformylase activity
AKL16_RS08320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKL16_RS08330	COG1758	RNA polymerase activity
AKL16_RS08335	COG0194	GDP metabolic process
AKL16_RS08350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKL16_RS08355	COG0505	Belongs to the CarA family
AKL16_RS08360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKL16_RS08370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKL16_RS08400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKL16_RS08410	COG0006	proline dipeptidase activity
AKL16_RS08415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKL16_RS08420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKL16_RS08425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKL16_RS08440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS08450	COG1120	ATPase activity
AKL16_RS08455	COG2826	transposase and inactivated derivatives, IS30 family
AKL16_RS08460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKL16_RS08465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKL16_RS08470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKL16_RS08500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKL16_RS08525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL16_RS08535	COG1760	l-serine dehydratase
AKL16_RS08540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKL16_RS08545	COG0124	histidyl-tRNA synthetase
AKL16_RS08555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKL16_RS08570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKL16_RS08575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKL16_RS08580	COG0747	negative chemotaxis
AKL16_RS08585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKL16_RS08590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKL16_RS08605	COG0632	four-way junction helicase activity
AKL16_RS08610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKL16_RS08615	COG0217	transcriptional regulatory protein
AKL16_RS08620	COG1946	Acyl-CoA thioesterase
AKL16_RS08635	COG0438	transferase activity, transferring glycosyl groups
AKL16_RS08640	COG1560	Kdo2-lipid A biosynthetic process
AKL16_RS08645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKL16_RS08655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKL16_RS08660	COG2837	iron assimilation
AKL16_RS08665	COG2847	Copper chaperone PCu(A)C
AKL16_RS08760	COG1929	Belongs to the glycerate kinase type-1 family
AKL16_RS08780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKL16_RS08785	COG3253	May function as heme-dependent peroxidase
AKL16_RS08795	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AKL16_RS08815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKL16_RS08845	COG0483	inositol monophosphate 1-phosphatase activity
AKL16_RS08860	COG2311	Membrane
AKL16_RS08870	COG1061	Type III restriction enzyme res subunit
AKL16_RS08900	COG1321	iron dependent repressor
AKL16_RS08905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKL16_RS08925	COG0583	DNA-binding transcription factor activity
AKL16_RS08935	COG1643	Atp-dependent helicase
AKL16_RS08955	COG1349	DNA-binding transcription factor activity
AKL16_RS08965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKL16_RS08975	COG1105	Belongs to the carbohydrate kinase PfkB family
AKL16_RS08980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AKL16_RS08980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKL16_RS08980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKL16_RS08995	COG2233	PERMEase
AKL16_RS09000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKL16_RS09015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKL16_RS09030	COG1196	nuclear chromosome segregation
AKL16_RS09050	COG1126	abc transporter atp-binding protein
AKL16_RS09055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKL16_RS09060	COG0765	amino acid transport
AKL16_RS09065	COG0765	amino acid transport
AKL16_RS09070	COG2137	regulation of response to DNA damage stimulus
AKL16_RS09090	COG1268	BioY protein
AKL16_RS09095	COG1122	ATPase activity
AKL16_RS09105	COG1842	Phage shock protein A
AKL16_RS09110	COG1396	sequence-specific DNA binding
AKL16_RS09135	COG1674	ftsk spoiiie
AKL16_RS09145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKL16_RS09150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKL16_RS09155	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AKL16_RS09170	COG1185	polyribonucleotide nucleotidyltransferase activity
AKL16_RS09200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKL16_RS09210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKL16_RS09215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKL16_RS09245	COG4166	transmembrane transport
AKL16_RS09250	COG0601	transmembrane transport
AKL16_RS09255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKL16_RS09265	COG4172	Belongs to the ABC transporter superfamily
AKL16_RS09275	COG3022	response to hydroperoxide
AKL16_RS09335	COG2197	response regulator
AKL16_RS09340	COG3850	Histidine kinase
AKL16_RS09345	COG0577	efflux transmembrane transporter activity
AKL16_RS09350	COG0577	efflux transmembrane transporter activity
AKL16_RS09350	COG1136	(ABC) transporter
AKL16_RS09355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKL16_RS09360	COG0750	zinc metalloprotease
AKL16_RS09380	COG1131	(ABC) transporter
AKL16_RS09385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKL16_RS09400	COG0233	cytoplasmic translational termination
AKL16_RS09410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKL16_RS09425	COG4974	Belongs to the 'phage' integrase family
AKL16_RS09435	COG0606	chelatase, subunit chli
AKL16_RS09440	COG0792	nuclease activity
AKL16_RS09450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKL16_RS09455	COG0681	Belongs to the peptidase S26 family
AKL16_RS09470	COG0352	thiamine-phosphate diphosphorylase activity
AKL16_RS09475	COG2022	thiamine diphosphate biosynthetic process
AKL16_RS09475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKL16_RS09485	COG2022	thiamine diphosphate biosynthetic process
AKL16_RS09490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKL16_RS09500	COG1609	Transcriptional regulator
AKL16_RS09505	COG0471	metal ion transport
AKL16_RS09515	COG2826	transposase and inactivated derivatives, IS30 family
AKL16_RS09530	COG0336	Belongs to the RNA methyltransferase TrmD family
AKL16_RS09540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKL16_RS09580	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKL16_RS09605	COG1196	nuclear chromosome segregation
AKL16_RS09610	COG1254	Belongs to the acylphosphatase family
AKL16_RS09640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKL16_RS09645	COG0571	ribonuclease III activity
AKL16_RS09660	COG1132	(ABC) transporter
AKL16_RS09665	COG1132	(ABC) transporter
AKL16_RS09670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKL16_RS09675	COG1929	Belongs to the glycerate kinase type-1 family
AKL16_RS09705	COG0058	SHG alpha-glucan phosphorylase activity
AKL16_RS09710	COG2514	catechol 2,3-dioxygenase activity
AKL16_RS09715	COG0469	pyruvate kinase activity
AKL16_RS09725	COG0134	indole-3-glycerol-phosphate synthase activity
AKL16_RS09745	COG0483	inositol monophosphate 1-phosphatase activity
AKL16_RS09750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKL16_RS09755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKL16_RS09780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKL16_RS09810	COG2264	protein methyltransferase activity
AKL16_RS09820	COG0673	inositol 2-dehydrogenase activity
AKL16_RS09825	COG1609	Transcriptional regulator
AKL16_RS09830	COG1120	ATPase activity
AKL16_RS09835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL16_RS09895	COG1739	Uncharacterized protein family UPF0029
AKL16_RS09905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKL16_RS09940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKL16_RS09950	COG0488	(ABC) transporter
AKL16_RS09960	COG0252	asparaginase activity
AKL16_RS09990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKL16_RS10000	COG3599	regulation of cell shape
AKL16_RS10010	COG1799	cell septum assembly
AKL16_RS10015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKL16_RS10020	COG1496	oxidoreductase activity
AKL16_RS10025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKL16_RS10030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AKL16_RS10035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKL16_RS10050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKL16_RS10055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKL16_RS10065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKL16_RS10070	COG0768	penicillin binding
AKL16_RS10080	COG0275	rRNA processing
AKL16_RS10100	COG0456	acetyltransferase
AKL16_RS10110	COG0142	geranyltranstransferase activity
AKL16_RS10125	COG2815	serine threonine protein kinase
AKL16_RS10125	COG0515	serine threonine protein kinase
AKL16_RS10140	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AKL16_RS10175	COG1940	carbohydrate kinase activity
AKL16_RS10180	COG0438	transferase activity, transferring glycosyl groups
AKL16_RS10195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKL16_RS10200	COG0723	plastoquinol--plastocyanin reductase activity
AKL16_RS10205	COG2010	Cytochrome c
AKL16_RS10210	COG1845	cytochrome c oxidase, subunit III
AKL16_RS10225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKL16_RS10265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKL16_RS10270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKL16_RS10280	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL16_RS10300	COG0569	domain protein
AKL16_RS10300	COG2985	domain, Protein
AKL16_RS10310	COG0174	glutamine synthetase
AKL16_RS10330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL16_RS10340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AKL16_RS10370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKL16_RS10375	COG0174	glutamine synthetase
AKL16_RS10400	COG0557	exoribonuclease II activity
AKL16_RS10425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKL16_RS10425	COG3323	Protein of unknown function (DUF1653)
AKL16_RS10470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AKL16_RS10495	COG0596	Alpha beta hydrolase
AKL16_RS10500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKL16_RS10570	COG3387	PFAM Glycoside hydrolase 15-related
AKL16_RS10580	COG0358	DNA primase activity
AKL16_RS10595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKL16_RS10605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AKL16_RS10630	COG0423	glycine-tRNA ligase activity
AKL16_RS10655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKL16_RS10665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKL16_RS10675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKL16_RS10690	COG0484	heat shock protein binding
AKL16_RS10730	COG1132	(ABC) transporter
AKL16_RS10755	COG0366	Alpha amylase catalytic
AKL16_RS10790	COG1114	Component of the transport system for branched-chain amino acids
AKL16_RS10795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL16_RS10800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKL16_RS10815	COG0247	lactate metabolic process
AKL16_RS10815	COG0277	FAD linked oxidase domain protein
AKL16_RS10840	COG0747	negative chemotaxis
AKL16_RS10845	COG0601	transmembrane transport
AKL16_RS10850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKL16_RS10865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL16_RS10875	COG0385	Bile acid
AKL16_RS10880	COG0676	glucose-6-phosphate 1-epimerase activity
AKL16_RS10885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKL16_RS10890	COG2224	Isocitrate lyase
AKL16_RS10905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKL16_RS10935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKL16_RS10945	COG0481	GTPase activity
AKL16_RS10960	COG1280	lysine exporter protein (LysE YggA)
AKL16_RS10985	COG1307	EDD domain protein, DegV family
AKL16_RS10990	COG0406	alpha-ribazole phosphatase activity
AKL16_RS11000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKL16_RS11015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKL16_RS11020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKL16_RS11025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKL16_RS11060	COG1530	ribonuclease E activity
AKL16_RS11105	COG0285	dihydrofolate synthase activity
AKL16_RS11110	COG0525	valine-tRNA ligase activity
AKL16_RS11120	COG0443	Heat shock 70 kDa protein
AKL16_RS11130	COG0039	L-malate dehydrogenase activity
AKL16_RS11135	COG1309	transcriptional regulator
AKL16_RS11155	COG2814	Major facilitator Superfamily
AKL16_RS11185	COG1414	Transcriptional regulator
AKL16_RS11190	COG0183	Belongs to the thiolase family
AKL16_RS11195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKL16_RS11210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKL16_RS11215	COG3485	protocatechuate 3,4-dioxygenase
AKL16_RS11220	COG3485	protocatechuate 3,4-dioxygenase
AKL16_RS11230	COG4829	muconolactone delta-isomerase
AKL16_RS11235	COG4948	Mandelate Racemase Muconate Lactonizing
AKL16_RS11240	COG3485	protocatechuate 3,4-dioxygenase
AKL16_RS11245	COG4638	Rieske (2fe-2S)
AKL16_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
AKL16_RS11270	COG2814	Major facilitator Superfamily
AKL16_RS11285	COG1960	acyl-CoA dehydrogenase activity
AKL16_RS11295	COG4638	Rieske (2fe-2S)
AKL16_RS11305	COG1028	Short-chain dehydrogenase reductase Sdr
AKL16_RS11310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKL16_RS11325	COG0154	amidase activity
AKL16_RS11330	COG2271	Major facilitator Superfamily
AKL16_RS11360	COG0740	serine-type endopeptidase activity
AKL16_RS11365	COG0740	serine-type endopeptidase activity
AKL16_RS11425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AKL16_RS11480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKL16_RS11485	COG0601	transmembrane transport
AKL16_RS11490	COG0747	negative chemotaxis
AKL16_RS11500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKL16_RS11515	COG4221	oxidoreductase activity
AKL16_RS11530	COG1119	ATPase activity
AKL16_RS11585	COG1785	Belongs to the alkaline phosphatase family
AKL16_RS11620	COG3842	ATPase activity
AKL16_RS11645	COG1335	isochorismatase
AKL16_RS11650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL16_RS11670	COG1691	(AIR) carboxylase
AKL16_RS11680	COG3622	Belongs to the hyi family
AKL16_RS11685	COG4221	oxidoreductase activity
AKL16_RS11700	COG1376	ErfK ybiS ycfS ynhG family protein
AKL16_RS11715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKL16_RS11735	COG2066	Belongs to the glutaminase family
AKL16_RS11740	COG1609	Transcriptional regulator
AKL16_RS11750	COG1609	Transcriptional regulator
AKL16_RS11755	COG1904	glucuronate isomerase
AKL16_RS11755	COG1102	Psort location Cytoplasmic, score
AKL16_RS11760	COG3265	gluconokinase activity
AKL16_RS11770	COG1335	isochorismatase
AKL16_RS11790	COG0736	holo-[acyl-carrier-protein] synthase activity
AKL16_RS11795	COG2814	Major facilitator Superfamily
AKL16_RS11860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKL16_RS11865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKL16_RS11930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKL16_RS11950	COG1309	transcriptional regulator
AKL16_RS12000	COG1234	tRNA 3'-trailer cleavage
AKL16_RS12005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKL16_RS12025	COG3191	aminopeptidase activity
AKL16_RS12045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKL16_RS12070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKL16_RS12085	COG2186	Transcriptional regulator
AKL16_RS12100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKL16_RS12120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKL16_RS12135	COG0604	alcohol dehydrogenase
AKL16_RS12140	COG2079	MmgE PrpD family protein
AKL16_RS12160	COG0033	Phosphoglucomutase
AKL16_RS12165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKL16_RS12170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKL16_RS12195	COG1136	(ABC) transporter
AKL16_RS12265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKL16_RS12275	COG2197	response regulator
AKL16_RS12290	COG1045	serine acetyltransferase
AKL16_RS12315	COG0045	succinate-CoA ligase (ADP-forming) activity
AKL16_RS12330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AKL16_RS12360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKL16_RS12380	COG0456	acetyltransferase
AKL16_RS12390	COG1597	lipid kinase activity
AKL16_RS12405	COG0354	folic acid binding
AKL16_RS12415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKL16_RS12440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKL16_RS12445	COG0047	phosphoribosylformylglycinamidine synthase activity
AKL16_RS12450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKL16_RS12455	COG0386	Belongs to the glutathione peroxidase family
AKL16_RS12475	COG1301	dicarboxylic acid transport
AKL16_RS12485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKL16_RS12490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKL16_RS12495	COG0436	Aminotransferase
AKL16_RS12500	COG0151	Belongs to the GarS family
AKL16_RS12505	COG0537	adenosine 5'-monophosphoramidase activity
AKL16_RS12510	COG4106	trans-aconitate 2-methyltransferase activity
AKL16_RS12515	COG3104	oligopeptide transport
AKL16_RS12520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKL16_RS12530	COG2205	protein histidine kinase activity
AKL16_RS12535	COG0745	RESPONSE REGULATOR receiver
AKL16_RS12540	COG0789	Transcriptional regulator
AKL16_RS12550	COG0028	Belongs to the TPP enzyme family
AKL16_RS12560	COG1309	transcriptional regulator
AKL16_RS12575	COG1053	succinate dehydrogenase
AKL16_RS12580	COG1053	succinate dehydrogenase
AKL16_RS12595	COG0477	Major facilitator Superfamily
AKL16_RS12600	COG0583	DNA-binding transcription factor activity
AKL16_RS12610	COG1748	Saccharopine dehydrogenase
AKL16_RS12650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AKL16_RS12665	COG1609	Transcriptional regulator
AKL16_RS12675	COG1121	(ABC) transporter
AKL16_RS12680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKL16_RS12685	COG1053	succinate dehydrogenase
AKL16_RS12695	COG0673	inositol 2-dehydrogenase activity
AKL16_RS12700	COG0477	Major facilitator Superfamily
AKL16_RS12710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKL16_RS12725	COG1621	beta-fructofuranosidase activity
AKL16_RS12735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AKL16_RS12740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKL16_RS12775	COG4166	transmembrane transport
AKL16_RS12790	COG4608	Belongs to the ABC transporter superfamily
AKL16_RS12795	COG1280	lysine exporter protein (LysE YggA)
AKL16_RS12810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKL16_RS12815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKL16_RS12830	COG2205	protein histidine kinase activity
AKL16_RS12835	COG2847	Copper chaperone PCu(A)C
AKL16_RS12840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKL16_RS12900	COG0542	response to heat
AKL16_RS12915	COG2207	Transcriptional regulator
AKL16_RS12940	COG2814	Major facilitator Superfamily
AKL16_RS12950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKL16_RS12955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKL16_RS12975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKL16_RS12990	COG0302	gtp cyclohydrolase
AKL16_RS12995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKL16_RS13005	COG0037	tRNA processing
AKL16_RS13010	COG2027	D-alanyl-D-alanine carboxypeptidase
AKL16_RS13015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AKL16_RS13020	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKL16_RS13025	COG3766	membrane
AKL16_RS13045	COG2190	(PTS) system
AKL16_RS13045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKL16_RS13045	COG1263	PTS System
AKL16_RS13050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKL16_RS13050	COG2190	(PTS) system
AKL16_RS13050	COG1263	PTS System
AKL16_RS13055	COG1263	PTS System
AKL16_RS13055	COG2190	(PTS) system
AKL16_RS13055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKL16_RS13070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKL16_RS13085	COG1012	belongs to the aldehyde dehydrogenase family
AKL16_RS13090	COG2326	polyphosphate kinase activity
AKL16_RS13100	COG0459	protein refolding
AKL16_RS13110	COG1100	Small GTP-binding protein
AKL16_RS13160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKL16_RS13160	COG2111	Na H antiporter
AKL16_RS13165	COG1006	Multisubunit Na H antiporter MnhC subunit
AKL16_RS13170	COG0651	ATP synthesis coupled electron transport
AKL16_RS13180	COG2212	antiporter activity
AKL16_RS13185	COG1320	monovalent cation:proton antiporter activity
AKL16_RS13210	COG0242	peptide deformylase activity
AKL16_RS13225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKL16_RS13230	COG2814	Major facilitator Superfamily
AKL16_RS13250	COG1131	(ABC) transporter
AKL16_RS13270	COG0515	serine threonine protein kinase
AKL16_RS13280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKL16_RS13285	COG0280	phosphate acetyltransferase
AKL16_RS13330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKL16_RS13335	COG4129	membrane
AKL16_RS13340	COG0191	fructose-bisphosphate aldolase activity
AKL16_RS13355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKL16_RS13365	COG2897	thiosulfate sulfurtransferase activity
AKL16_RS13385	COG0542	response to heat
AKL16_RS13395	COG0640	Transcriptional regulator
AKL16_RS13455	COG1012	belongs to the aldehyde dehydrogenase family
AKL16_RS13460	COG0789	Transcriptional regulator
AKL16_RS13465	COG0484	heat shock protein binding
AKL16_RS13470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKL16_RS13475	COG0443	Heat shock 70 kDa protein
AKL16_RS13520	COG0730	response to heat
AKL16_RS13550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKL16_RS13595	COG1162	GTPase activity
AKL16_RS13605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKL16_RS13615	COG1122	ATPase activity
AKL16_RS13635	COG1957	nucleoside hydrolase
AKL16_RS13650	COG2818	Glycosylase
AKL16_RS13655	COG1017	nitric oxide dioxygenase activity
AKL16_RS13655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKL16_RS13665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKL16_RS13700	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKL16_RS13725	COG1472	Belongs to the glycosyl hydrolase 3 family
AKL16_RS13740	COG4981	capsule polysaccharide biosynthetic process
AKL16_RS13765	COG0438	transferase activity, transferring glycosyl groups
AKL16_RS13775	COG0500	methyltransferase
AKL16_RS13815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKL16_RS13820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKL16_RS13820	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AKL16_RS13820	COG3321	synthase
AKL16_RS13825	COG0318	PFAM AMP-dependent synthetase and ligase
AKL16_RS13830	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AKL16_RS13840	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AKL16_RS13840	COG5479	isomerase activity
AKL16_RS13860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKL16_RS13865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKL16_RS13870	COG0671	phosphoesterase, PA-phosphatase related
AKL16_RS13875	COG1216	Glycosyl transferase, family 2
AKL16_RS13885	COG0671	phosphoesterase, PA-phosphatase related
AKL16_RS13915	COG0561	phosphatase activity
AKL16_RS13925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKL16_RS13930	COG2188	Transcriptional regulator
AKL16_RS13950	COG0077	Prephenate dehydratase
AKL16_RS13955	COG0154	amidase activity
AKL16_RS13970	COG1316	TRANSCRIPTIONal
AKL16_RS14005	COG2610	gluconate transmembrane transporter activity
AKL16_RS14010	COG0469	pyruvate kinase activity
AKL16_RS14015	COG0039	L-malate dehydrogenase activity
AKL16_RS14035	COG2188	Transcriptional regulator
AKL16_RS14040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKL16_RS14045	COG0477	Major facilitator Superfamily
AKL16_RS14090	COG0583	DNA-binding transcription factor activity
AKL16_RS14095	COG2814	Major facilitator Superfamily
AKL16_RS14125	COG2197	response regulator
AKL16_RS14145	COG3764	Sortase (surface protein transpeptidase)
AKL16_RS14150	COG0706	membrane insertase activity
AKL16_RS14175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL16_RS14180	COG0564	pseudouridine synthase activity
AKL16_RS14220	COG1842	Phage shock protein A
AKL16_RS14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKL16_RS14240	COG0477	Major facilitator Superfamily
AKL16_RS14250	COG1695	Transcriptional regulator
AKL16_RS14255	COG0305	Participates in initiation and elongation during chromosome replication
AKL16_RS14265	COG0629	single-stranded DNA binding
AKL16_RS14270	COG0360	Binds together with S18 to 16S ribosomal RNA
AKL16_RS14285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKL16_RS14295	COG1846	Transcriptional regulator
AKL16_RS14325	COG1136	(ABC) transporter
AKL16_RS14335	COG1260	myo-inositol-1-phosphate synthase
AKL16_RS14345	COG4868	Belongs to the UPF0371 family
AKL16_RS14350	COG0783	Belongs to the Dps family
AKL16_RS14355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKL16_RS14360	COG1690	Belongs to the RtcB family
AKL16_RS14365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKL16_RS14405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKL16_RS14410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKL16_RS14425	COG0778	Nitroreductase
AKL16_RS14440	COG2832	Protein of unknown function (DUF454)
AKL16_RS14455	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKL16_RS14470	COG2814	Major facilitator Superfamily
AKL16_RS14475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKL16_RS14495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKL16_RS14500	COG0512	Glutamine amidotransferase of anthranilate synthase
AKL16_RS14510	COG0134	indole-3-glycerol-phosphate synthase activity
AKL16_RS14510	COG0135	phosphoribosylanthranilate isomerase activity
AKL16_RS14515	COG0133	tryptophan synthase activity
AKL16_RS14520	COG0159	tryptophan synthase activity
AKL16_RS14530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKL16_RS14535	COG1131	(ABC) transporter
AKL16_RS14565	COG0640	Transcriptional regulator
AKL16_RS14570	COG1902	pentaerythritol trinitrate reductase activity
AKL16_RS14605	COG3104	oligopeptide transport
AKL16_RS14610	COG1309	transcriptional regulator
AKL16_RS14620	COG1454	alcohol dehydrogenase
AKL16_RS14625	COG2814	Major facilitator Superfamily
AKL16_RS14630	COG1414	Transcriptional regulator
AKL16_RS14635	COG0673	inositol 2-dehydrogenase activity
AKL16_RS14645	COG0673	inositol 2-dehydrogenase activity
AKL16_RS14650	COG0673	inositol 2-dehydrogenase activity
AKL16_RS14660	COG0477	Major facilitator Superfamily
AKL16_RS14685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKL16_RS14705	COG0351	phosphomethylpyrimidine kinase
AKL16_RS14715	COG2608	mercury ion transmembrane transporter activity
AKL16_RS14720	COG1687	branched-chain amino acid
AKL16_RS14725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKL16_RS14730	COG1678	Uncharacterized ACR, COG1678
AKL16_RS14735	COG0617	tRNA 3'-terminal CCA addition
AKL16_RS14755	COG1595	DNA-templated transcription, initiation
AKL16_RS14765	COG3118	belongs to the thioredoxin family
AKL16_RS14770	COG3409	Peptidoglycan-binding domain 1 protein
AKL16_RS14770	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKL16_RS14785	COG1192	Involved in chromosome partitioning
AKL16_RS14800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKL16_RS14805	COG0594	ribonuclease P activity