locus-tag	class	description
C0I99_RS00005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0I99_RS00025	COG1414	Transcriptional regulator
C0I99_RS00030	COG0183	Belongs to the thiolase family
C0I99_RS00035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0I99_RS00050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0I99_RS00055	COG3485	protocatechuate 3,4-dioxygenase
C0I99_RS00060	COG3485	protocatechuate 3,4-dioxygenase
C0I99_RS00070	COG4829	muconolactone delta-isomerase
C0I99_RS00075	COG4948	Mandelate Racemase Muconate Lactonizing
C0I99_RS00080	COG3485	protocatechuate 3,4-dioxygenase
C0I99_RS00085	COG4638	Rieske (2fe-2S)
C0I99_RS00100	COG1028	Short-chain dehydrogenase reductase Sdr
C0I99_RS00110	COG2814	Major facilitator Superfamily
C0I99_RS00120	COG0740	serine-type endopeptidase activity
C0I99_RS00125	COG0740	serine-type endopeptidase activity
C0I99_RS00190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0I99_RS00240	COG4172	Belongs to the ABC transporter superfamily
C0I99_RS00245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0I99_RS00250	COG0601	transmembrane transport
C0I99_RS00255	COG0747	negative chemotaxis
C0I99_RS00265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0I99_RS00280	COG4221	oxidoreductase activity
C0I99_RS00295	COG1119	ATPase activity
C0I99_RS00300	COG2346	COG2346, Truncated hemoglobins
C0I99_RS00350	COG1785	Belongs to the alkaline phosphatase family
C0I99_RS00390	COG3842	ATPase activity
C0I99_RS00395	COG0463	Glycosyl transferase, family 2
C0I99_RS00420	COG1691	(AIR) carboxylase
C0I99_RS00425	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C0I99_RS00430	COG3622	Belongs to the hyi family
C0I99_RS00435	COG4221	oxidoreductase activity
C0I99_RS00440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0I99_RS00450	COG1376	ErfK ybiS ycfS ynhG family protein
C0I99_RS00490	COG2066	Belongs to the glutaminase family
C0I99_RS00495	COG1609	Transcriptional regulator
C0I99_RS00510	COG1102	Psort location Cytoplasmic, score
C0I99_RS00510	COG1904	glucuronate isomerase
C0I99_RS00515	COG3265	gluconokinase activity
C0I99_RS00525	COG1335	isochorismatase
C0I99_RS00545	COG0736	holo-[acyl-carrier-protein] synthase activity
C0I99_RS00550	COG2814	Major facilitator Superfamily
C0I99_RS00575	COG3835	regulator
C0I99_RS00600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C0I99_RS00605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0I99_RS00650	COG1234	tRNA 3'-trailer cleavage
C0I99_RS00655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0I99_RS00675	COG3191	aminopeptidase activity
C0I99_RS00695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C0I99_RS00720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0I99_RS00735	COG2186	Transcriptional regulator
C0I99_RS00750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0I99_RS00770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0I99_RS00790	COG2079	MmgE PrpD family protein
C0I99_RS00810	COG0033	Phosphoglucomutase
C0I99_RS00815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0I99_RS00820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0I99_RS00825	COG4336	lyase activity
C0I99_RS00875	COG1136	(ABC) transporter
C0I99_RS00945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0I99_RS00955	COG2197	response regulator
C0I99_RS00970	COG1045	serine acetyltransferase
C0I99_RS00995	COG0045	succinate-CoA ligase (ADP-forming) activity
C0I99_RS01010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0I99_RS01040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0I99_RS01060	COG0456	acetyltransferase
C0I99_RS01070	COG1597	lipid kinase activity
C0I99_RS01085	COG0354	folic acid binding
C0I99_RS01095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0I99_RS01120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0I99_RS01125	COG0047	phosphoribosylformylglycinamidine synthase activity
C0I99_RS01130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0I99_RS01135	COG0386	Belongs to the glutathione peroxidase family
C0I99_RS01165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0I99_RS01170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0I99_RS01175	COG0436	Aminotransferase
C0I99_RS01180	COG0151	Belongs to the GarS family
C0I99_RS01185	COG0537	adenosine 5'-monophosphoramidase activity
C0I99_RS01195	COG3104	oligopeptide transport
C0I99_RS01200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0I99_RS01205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0I99_RS01210	COG2205	protein histidine kinase activity
C0I99_RS01215	COG0745	RESPONSE REGULATOR receiver
C0I99_RS01220	COG0789	Transcriptional regulator
C0I99_RS01230	COG0028	Belongs to the TPP enzyme family
C0I99_RS01240	COG1309	transcriptional regulator
C0I99_RS01255	COG1053	succinate dehydrogenase
C0I99_RS01260	COG0583	DNA-binding transcription factor activity
C0I99_RS01265	COG1748	Saccharopine dehydrogenase
C0I99_RS01305	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C0I99_RS01320	COG1609	Transcriptional regulator
C0I99_RS01330	COG1121	(ABC) transporter
C0I99_RS01335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0I99_RS01350	COG1053	succinate dehydrogenase
C0I99_RS01365	COG0673	inositol 2-dehydrogenase activity
C0I99_RS01380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0I99_RS01385	COG0215	cysteine-tRNA ligase activity
C0I99_RS01395	COG1621	beta-fructofuranosidase activity
C0I99_RS01400	COG0363	glucosamine-6-phosphate deaminase activity
C0I99_RS01405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0I99_RS01410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0I99_RS01440	COG4166	transmembrane transport
C0I99_RS01450	COG0444	Belongs to the ABC transporter superfamily
C0I99_RS01455	COG4608	Belongs to the ABC transporter superfamily
C0I99_RS01460	COG1280	lysine exporter protein (LysE YggA)
C0I99_RS01465	COG1522	sequence-specific DNA binding
C0I99_RS01475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0I99_RS01480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C0I99_RS01495	COG2205	protein histidine kinase activity
C0I99_RS01500	COG2847	Copper chaperone PCu(A)C
C0I99_RS01505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0I99_RS01510	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C0I99_RS01565	COG0542	response to heat
C0I99_RS01575	COG2207	Transcriptional regulator
C0I99_RS01600	COG2814	Major facilitator Superfamily
C0I99_RS01610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0I99_RS01615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0I99_RS01635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0I99_RS01650	COG0302	gtp cyclohydrolase
C0I99_RS01655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0I99_RS01665	COG0037	tRNA processing
C0I99_RS01670	COG2027	D-alanyl-D-alanine carboxypeptidase
C0I99_RS01675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0I99_RS01680	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0I99_RS01685	COG3766	membrane
C0I99_RS01705	COG1263	PTS System
C0I99_RS01705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0I99_RS01705	COG2190	(PTS) system
C0I99_RS01710	COG2190	(PTS) system
C0I99_RS01710	COG1263	PTS System
C0I99_RS01710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0I99_RS01725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0I99_RS01740	COG1012	belongs to the aldehyde dehydrogenase family
C0I99_RS01745	COG2326	polyphosphate kinase activity
C0I99_RS01755	COG0459	protein refolding
C0I99_RS01765	COG1100	Small GTP-binding protein
C0I99_RS01815	COG2111	Na H antiporter
C0I99_RS01815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0I99_RS01820	COG1006	Multisubunit Na H antiporter MnhC subunit
C0I99_RS01825	COG0651	ATP synthesis coupled electron transport
C0I99_RS01835	COG2212	antiporter activity
C0I99_RS01840	COG1320	monovalent cation:proton antiporter activity
C0I99_RS01865	COG0242	peptide deformylase activity
C0I99_RS01880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0I99_RS01890	COG2814	Major facilitator Superfamily
C0I99_RS01910	COG1131	(ABC) transporter
C0I99_RS01930	COG0515	serine threonine protein kinase
C0I99_RS01940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0I99_RS01945	COG0280	phosphate acetyltransferase
C0I99_RS02010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0I99_RS02020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0I99_RS02025	COG4129	membrane
C0I99_RS02030	COG0191	fructose-bisphosphate aldolase activity
C0I99_RS02045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0I99_RS02055	COG2897	thiosulfate sulfurtransferase activity
C0I99_RS02075	COG0542	response to heat
C0I99_RS02085	COG0640	Transcriptional regulator
C0I99_RS02155	COG1012	belongs to the aldehyde dehydrogenase family
C0I99_RS02160	COG0789	Transcriptional regulator
C0I99_RS02165	COG0484	heat shock protein binding
C0I99_RS02170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0I99_RS02175	COG0443	Heat shock 70 kDa protein
C0I99_RS02225	COG0730	response to heat
C0I99_RS02255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0I99_RS02305	COG1162	GTPase activity
C0I99_RS02315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0I99_RS02325	COG1122	ATPase activity
C0I99_RS02345	COG1957	nucleoside hydrolase
C0I99_RS02360	COG2818	Glycosylase
C0I99_RS02365	COG1017	nitric oxide dioxygenase activity
C0I99_RS02365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0I99_RS02375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C0I99_RS02400	COG2826	transposase and inactivated derivatives, IS30 family
C0I99_RS02410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C0I99_RS02435	COG1472	Belongs to the glycosyl hydrolase 3 family
C0I99_RS02450	COG4981	capsule polysaccharide biosynthetic process
C0I99_RS02475	COG0438	transferase activity, transferring glycosyl groups
C0I99_RS02485	COG0500	methyltransferase
C0I99_RS02490	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C0I99_RS02525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0I99_RS02530	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C0I99_RS02530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0I99_RS02530	COG3321	synthase
C0I99_RS02535	COG0318	PFAM AMP-dependent synthetase and ligase
C0I99_RS02540	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C0I99_RS02550	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C0I99_RS02550	COG5479	isomerase activity
C0I99_RS02565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0I99_RS02570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0I99_RS02575	COG0671	phosphoesterase, PA-phosphatase related
C0I99_RS02580	COG1216	Glycosyl transferase, family 2
C0I99_RS02590	COG0671	phosphoesterase, PA-phosphatase related
C0I99_RS02620	COG0561	phosphatase activity
C0I99_RS02630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0I99_RS02635	COG2188	Transcriptional regulator
C0I99_RS02655	COG0077	Prephenate dehydratase
C0I99_RS02675	COG1316	TRANSCRIPTIONal
C0I99_RS02705	COG2610	gluconate transmembrane transporter activity
C0I99_RS02710	COG0469	pyruvate kinase activity
C0I99_RS02715	COG0039	L-malate dehydrogenase activity
C0I99_RS02735	COG2188	Transcriptional regulator
C0I99_RS02740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C0I99_RS02745	COG0477	Major facilitator Superfamily
C0I99_RS02775	COG1473	amidohydrolase
C0I99_RS02780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0I99_RS02790	COG0583	DNA-binding transcription factor activity
C0I99_RS02795	COG2814	Major facilitator Superfamily
C0I99_RS02825	COG2197	response regulator
C0I99_RS02845	COG3764	Sortase (surface protein transpeptidase)
C0I99_RS02850	COG0706	membrane insertase activity
C0I99_RS02875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0I99_RS02885	COG0564	pseudouridine synthase activity
C0I99_RS02925	COG1842	Phage shock protein A
C0I99_RS03010	COG2217	Heavy metal translocating P-type atpase
C0I99_RS03020	COG2205	protein histidine kinase activity
C0I99_RS03025	COG0745	RESPONSE REGULATOR receiver
C0I99_RS03045	COG1063	alcohol dehydrogenase
C0I99_RS03055	COG2608	mercury ion transmembrane transporter activity
C0I99_RS03075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0I99_RS03085	COG0477	Major facilitator Superfamily
C0I99_RS03095	COG1695	Transcriptional regulator
C0I99_RS03100	COG0305	Participates in initiation and elongation during chromosome replication
C0I99_RS03105	COG0359	binds to the 23S rRNA
C0I99_RS03110	COG0629	single-stranded DNA binding
C0I99_RS03115	COG0360	Binds together with S18 to 16S ribosomal RNA
C0I99_RS03130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0I99_RS03140	COG1846	Transcriptional regulator
C0I99_RS03160	COG1054	Belongs to the UPF0176 family
C0I99_RS03170	COG1136	(ABC) transporter
C0I99_RS03180	COG1260	myo-inositol-1-phosphate synthase
C0I99_RS03190	COG4868	Belongs to the UPF0371 family
C0I99_RS03195	COG0783	Belongs to the Dps family
C0I99_RS03200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0I99_RS03205	COG1690	Belongs to the RtcB family
C0I99_RS03215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0I99_RS03250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0I99_RS03255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0I99_RS03275	COG0778	Nitroreductase
C0I99_RS03285	COG0495	leucyl-tRNA aminoacylation
C0I99_RS03290	COG2832	Protein of unknown function (DUF454)
C0I99_RS03305	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0I99_RS03320	COG2814	Major facilitator Superfamily
C0I99_RS03325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0I99_RS03350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0I99_RS03355	COG0512	Glutamine amidotransferase of anthranilate synthase
C0I99_RS03365	COG0135	phosphoribosylanthranilate isomerase activity
C0I99_RS03365	COG0134	indole-3-glycerol-phosphate synthase activity
C0I99_RS03370	COG0133	tryptophan synthase activity
C0I99_RS03375	COG0159	tryptophan synthase activity
C0I99_RS03385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0I99_RS03390	COG1131	(ABC) transporter
C0I99_RS03425	COG1902	pentaerythritol trinitrate reductase activity
C0I99_RS03430	COG0702	epimerase
C0I99_RS03460	COG3104	oligopeptide transport
C0I99_RS03465	COG1309	transcriptional regulator
C0I99_RS03475	COG1454	alcohol dehydrogenase
C0I99_RS03480	COG2814	Major facilitator Superfamily
C0I99_RS03485	COG1414	Transcriptional regulator
C0I99_RS03490	COG0673	inositol 2-dehydrogenase activity
C0I99_RS03500	COG0673	inositol 2-dehydrogenase activity
C0I99_RS03505	COG0673	inositol 2-dehydrogenase activity
C0I99_RS03510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C0I99_RS03520	COG0477	Major facilitator Superfamily
C0I99_RS03545	COG0351	phosphomethylpyrimidine kinase
C0I99_RS03550	COG2608	mercury ion transmembrane transporter activity
C0I99_RS03560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0I99_RS03580	COG0351	phosphomethylpyrimidine kinase
C0I99_RS03590	COG2608	mercury ion transmembrane transporter activity
C0I99_RS03595	COG1687	branched-chain amino acid
C0I99_RS03600	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C0I99_RS03605	COG1678	Uncharacterized ACR, COG1678
C0I99_RS03610	COG0617	tRNA 3'-terminal CCA addition
C0I99_RS03630	COG1595	DNA-templated transcription, initiation
C0I99_RS03640	COG3118	belongs to the thioredoxin family
C0I99_RS03645	COG3409	Peptidoglycan-binding domain 1 protein
C0I99_RS03645	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0I99_RS03660	COG1192	Involved in chromosome partitioning
C0I99_RS03665	COG0357	Ribosomal RNA small subunit methyltransferase G
C0I99_RS03675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0I99_RS03680	COG0594	ribonuclease P activity
C0I99_RS03700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0I99_RS03710	COG0592	DNA-directed DNA polymerase activity
C0I99_RS03715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0I99_RS03725	COG0187	DNA topoisomerase II activity
C0I99_RS03780	COG2855	membrane
C0I99_RS03785	COG0583	DNA-binding transcription factor activity
C0I99_RS03800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0I99_RS03800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0I99_RS03845	COG1764	response to oxidative stress
C0I99_RS03860	COG0803	Belongs to the bacterial solute-binding protein 9 family
C0I99_RS03865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0I99_RS03870	COG1120	ATPase activity
C0I99_RS03880	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0I99_RS03885	COG1129	ABC transporter
C0I99_RS03910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS03915	COG1120	ATPase activity
C0I99_RS03930	COG2815	serine threonine protein kinase
C0I99_RS03930	COG0515	serine threonine protein kinase
C0I99_RS03935	COG0515	serine threonine protein kinase
C0I99_RS03940	COG0768	penicillin binding
C0I99_RS03960	COG1716	ATPase activity
C0I99_RS03995	COG0730	response to heat
C0I99_RS04000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0I99_RS04005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0I99_RS04010	COG1937	Protein conserved in bacteria
C0I99_RS04055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0I99_RS04065	COG2851	Citrate transporter
C0I99_RS04070	COG3290	protein histidine kinase activity
C0I99_RS04075	COG4565	transcriptional regulatory protein
C0I99_RS04080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0I99_RS04090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0I99_RS04135	COG0402	S-adenosylhomocysteine deaminase activity
C0I99_RS04150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0I99_RS04180	COG0832	Belongs to the urease beta subunit family
C0I99_RS04185	COG0804	urea catabolic process
C0I99_RS04190	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C0I99_RS04195	COG0830	nickel cation binding
C0I99_RS04200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0I99_RS04205	COG0829	nickel cation binding
C0I99_RS04215	COG2814	Major facilitator Superfamily
C0I99_RS04225	COG0326	Molecular chaperone. Has ATPase activity
C0I99_RS04230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0I99_RS04250	COG1012	belongs to the aldehyde dehydrogenase family
C0I99_RS04255	COG0667	Aldo Keto reductase
C0I99_RS04260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C0I99_RS04270	COG2149	membrane
C0I99_RS04295	COG0346	lactoylglutathione lyase activity
C0I99_RS04310	COG2814	Major facilitator Superfamily
C0I99_RS04320	COG1070	Carbohydrate kinase
C0I99_RS04325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0I99_RS04330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C0I99_RS04335	COG3177	Filamentation induced by cAMP protein fic
C0I99_RS04360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0I99_RS04425	COG2860	membrane
C0I99_RS04445	COG3180	Ammonia monooxygenase
C0I99_RS04455	COG0730	response to heat
C0I99_RS04465	COG1643	Atp-dependent helicase
C0I99_RS04470	COG0110	maltose O-acetyltransferase activity
C0I99_RS04480	COG2818	Glycosylase
C0I99_RS04485	COG1280	lysine exporter protein (LysE YggA)
C0I99_RS04515	COG0251	oxidation-reduction process
C0I99_RS04525	COG3590	peptidase
C0I99_RS04540	COG2188	Transcriptional regulator
C0I99_RS04545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0I99_RS04560	COG3718	enzyme involved in inositol metabolism
C0I99_RS04565	COG3962	Belongs to the TPP enzyme family
C0I99_RS04575	COG0673	inositol 2-dehydrogenase activity
C0I99_RS04580	COG1082	Xylose isomerase domain protein TIM barrel
C0I99_RS04590	COG0673	inositol 2-dehydrogenase activity
C0I99_RS04595	COG2161	toxin-antitoxin pair type II binding
C0I99_RS04610	COG0673	inositol 2-dehydrogenase activity
C0I99_RS04625	COG1278	Cold shock
C0I99_RS04650	COG1609	Transcriptional regulator
C0I99_RS04660	COG2814	Major facilitator Superfamily
C0I99_RS04665	COG2826	transposase and inactivated derivatives, IS30 family
C0I99_RS04675	COG0067	glutamate synthase
C0I99_RS04675	COG0069	glutamate synthase activity
C0I99_RS04675	COG0070	glutamate synthase
C0I99_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
C0I99_RS04705	COG0277	FAD linked oxidase domain protein
C0I99_RS04740	COG2258	MOSC domain
C0I99_RS04745	COG1216	Glycosyl transferase, family 2
C0I99_RS04790	COG1115	amino acid carrier protein
C0I99_RS04815	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0I99_RS04815	COG0315	cyclic pyranopterin monophosphate synthase activity
C0I99_RS04820	COG0315	cyclic pyranopterin monophosphate synthase activity
C0I99_RS04835	COG0725	ABC transporter, periplasmic molybdate-binding protein
C0I99_RS04845	COG3842	ATPase activity
C0I99_RS04850	COG1950	PFAM Membrane protein of
C0I99_RS04855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0I99_RS04890	COG1231	oxidoreductase activity
C0I99_RS04895	COG2239	Acts as a magnesium transporter
C0I99_RS04900	COG0471	metal ion transport
C0I99_RS04910	COG0287	Prephenate dehydrogenase
C0I99_RS04925	COG3237	CsbD-like
C0I99_RS04940	COG2409	Drug exporters of the RND superfamily
C0I99_RS04945	COG0343	queuine tRNA-ribosyltransferase activity
C0I99_RS04965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0I99_RS04995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0I99_RS05015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0I99_RS05020	COG3442	glutamine amidotransferase
C0I99_RS05025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0I99_RS05040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0I99_RS05045	COG0697	spore germination
C0I99_RS05050	COG0527	aspartate kinase activity
C0I99_RS05055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0I99_RS05085	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C0I99_RS05105	COG0798	PFAM Bile acid sodium symporter
C0I99_RS05110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0I99_RS05130	COG0651	ATP synthesis coupled electron transport
C0I99_RS05135	COG1006	Multisubunit Na H antiporter MnhC subunit
C0I99_RS05140	COG2111	Na H antiporter
C0I99_RS05140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0I99_RS05155	COG0745	RESPONSE REGULATOR receiver
C0I99_RS05160	COG5002	protein histidine kinase activity
C0I99_RS05160	COG3850	Histidine kinase
C0I99_RS05190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0I99_RS05205	COG0251	oxidation-reduction process
C0I99_RS05210	COG0477	Major facilitator Superfamily
C0I99_RS05225	COG1028	Short-chain dehydrogenase reductase Sdr
C0I99_RS05235	COG1960	acyl-CoA dehydrogenase activity
C0I99_RS05245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0I99_RS05250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0I99_RS05265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0I99_RS05330	COG1111	helicase
C0I99_RS05330	COG1205	dead DEAH box helicase
C0I99_RS05335	COG1278	Cold shock
C0I99_RS05340	COG1754	DNA topoisomerase type I activity
C0I99_RS05340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0I99_RS05380	COG0564	pseudouridine synthase activity
C0I99_RS05410	COG2814	Major facilitator Superfamily
C0I99_RS05440	COG1525	nuclease
C0I99_RS05440	COG4085	toxin activity
C0I99_RS05440	COG0737	Belongs to the 5'-nucleotidase family
C0I99_RS05450	COG1064	alcohol dehydrogenase
C0I99_RS05465	COG1088	dTDP-glucose 4,6-dehydratase activity
C0I99_RS05470	COG0778	Nitroreductase
C0I99_RS05475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0I99_RS05495	COG1505	serine-type exopeptidase activity
C0I99_RS05520	COG0489	protein tyrosine kinase activity
C0I99_RS05525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0I99_RS05540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0I99_RS05545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0I99_RS05555	COG2244	polysaccharide biosynthetic process
C0I99_RS05560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0I99_RS05565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0I99_RS05570	COG1215	transferase activity, transferring glycosyl groups
C0I99_RS05585	COG2755	lipolytic protein G-D-S-L family
C0I99_RS05585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C0I99_RS05610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0I99_RS05615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0I99_RS05620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0I99_RS05625	COG3800	Transcriptional regulator
C0I99_RS05625	COG1396	sequence-specific DNA binding
C0I99_RS05635	COG1053	succinate dehydrogenase
C0I99_RS05640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0I99_RS05660	COG2733	membrane
C0I99_RS05675	COG1309	transcriptional regulator
C0I99_RS05690	COG0788	formyltetrahydrofolate deformylase activity
C0I99_RS05695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0I99_RS05705	COG1937	Protein conserved in bacteria
C0I99_RS05725	COG4558	Periplasmic binding protein
C0I99_RS05730	COG4139	cobalamin transport
C0I99_RS05735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C0I99_RS05765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0I99_RS05775	COG0318	PFAM AMP-dependent synthetase and ligase
C0I99_RS05790	COG5002	protein histidine kinase activity
C0I99_RS05795	COG0745	RESPONSE REGULATOR receiver
C0I99_RS05805	COG0577	efflux transmembrane transporter activity
C0I99_RS05825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0I99_RS05850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0I99_RS05855	COG0181	hydroxymethylbilane synthase activity
C0I99_RS05875	COG0477	Major facilitator Superfamily
C0I99_RS05880	COG1082	Xylose isomerase domain protein TIM barrel
C0I99_RS05880	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C0I99_RS05885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0I99_RS05890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0I99_RS05895	COG0222	ribosome binding
C0I99_RS05900	COG3842	ATPase activity
C0I99_RS05920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0I99_RS05920	COG1648	precorrin-2 dehydrogenase activity
C0I99_RS05930	COG0113	porphobilinogen synthase activity
C0I99_RS05945	COG2217	Heavy metal translocating P-type atpase
C0I99_RS05950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0I99_RS05960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0I99_RS05965	COG0406	alpha-ribazole phosphatase activity
C0I99_RS05975	COG0785	Cytochrome C biogenesis protein
C0I99_RS05980	COG1333	cytochrome c biogenesis protein
C0I99_RS05985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0I99_RS06040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0I99_RS06045	COG0583	DNA-binding transcription factor activity
C0I99_RS06085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C0I99_RS06090	COG2154	pterin-4-alpha-carbinolamine dehydratase
C0I99_RS06095	COG3340	Belongs to the peptidase S51 family
C0I99_RS06100	COG4948	Mandelate Racemase Muconate Lactonizing
C0I99_RS06115	COG0438	transferase activity, transferring glycosyl groups
C0I99_RS06115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0I99_RS06120	COG1113	amino acid transport
C0I99_RS06125	COG2226	methyltransferase
C0I99_RS06135	COG0142	geranyltranstransferase activity
C0I99_RS06165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0I99_RS06175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0I99_RS06220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0I99_RS06235	COG0085	RNA polymerase activity
C0I99_RS06240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0I99_RS06270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0I99_RS06275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0I99_RS06285	COG1120	ATPase activity
C0I99_RS06290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS06295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS06400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0I99_RS06425	COG3845	ABC transporter
C0I99_RS06460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0I99_RS06470	COG1841	ribosomal large subunit assembly
C0I99_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
C0I99_RS06515	COG0574	Belongs to the PEP-utilizing enzyme family
C0I99_RS06515	COG3848	Pyruvate phosphate dikinase
C0I99_RS06530	COG1414	Transcriptional regulator
C0I99_RS06535	COG0201	protein transport
C0I99_RS06570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0I99_RS06575	COG0202	RNA polymerase activity
C0I99_RS06580	COG0203	ribosomal protein L17
C0I99_RS06585	COG0101	tRNA pseudouridine synthase activity
C0I99_RS06615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0I99_RS06625	COG1404	Belongs to the peptidase S8 family
C0I99_RS06635	COG1674	ftsk spoiiie
C0I99_RS06665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0I99_RS06690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0I99_RS06700	COG0569	domain protein
C0I99_RS06700	COG2985	domain, Protein
C0I99_RS06715	COG0456	acetyltransferase
C0I99_RS06720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0I99_RS06725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0I99_RS06725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0I99_RS06740	COG0459	protein refolding
C0I99_RS06770	COG0516	GMP reductase activity
C0I99_RS06780	COG0583	DNA-binding transcription factor activity
C0I99_RS06785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0I99_RS06785	COG0519	Catalyzes the synthesis of GMP from XMP
C0I99_RS06810	COG2197	response regulator
C0I99_RS06835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0I99_RS06850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0I99_RS06875	COG2409	Drug exporters of the RND superfamily
C0I99_RS06895	COG0702	epimerase
C0I99_RS06900	COG0415	Belongs to the DNA photolyase family
C0I99_RS06905	COG1216	Glycosyl transferase, family 2
C0I99_RS06915	COG0577	efflux transmembrane transporter activity
C0I99_RS06915	COG1136	(ABC) transporter
C0I99_RS06920	COG2011	ABC-type metal ion transport system permease component
C0I99_RS06925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0I99_RS06930	COG1464	Belongs to the NlpA lipoprotein family
C0I99_RS06935	COG0587	DNA-directed DNA polymerase activity
C0I99_RS06960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0I99_RS06970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0I99_RS06975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0I99_RS07000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0I99_RS07005	COG2873	o-acetylhomoserine
C0I99_RS07010	COG1966	Carbon starvation protein
C0I99_RS07020	COG2079	MmgE PrpD family protein
C0I99_RS07025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C0I99_RS07030	COG0372	Belongs to the citrate synthase family
C0I99_RS07040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C0I99_RS07055	COG2838	Isocitrate dehydrogenase
C0I99_RS07065	COG1120	ATPase activity
C0I99_RS07070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS07075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS07085	COG2814	Major facilitator Superfamily
C0I99_RS07095	COG2860	membrane
C0I99_RS07110	COG1120	ATPase activity
C0I99_RS07115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS07120	COG0180	Tryptophanyl-tRNA synthetase
C0I99_RS07125	COG1295	ribonuclease BN
C0I99_RS07135	COG1686	Belongs to the peptidase S11 family
C0I99_RS07145	COG0791	NLP P60 protein
C0I99_RS07145	COG0741	lytic transglycosylase activity
C0I99_RS07165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0I99_RS07170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C0I99_RS07170	COG1473	amidohydrolase
C0I99_RS07180	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C0I99_RS07195	COG0523	cobalamin synthesis protein
C0I99_RS07200	COG0492	ferredoxin-NADP+ reductase activity
C0I99_RS07205	COG2079	MmgE PrpD family protein
C0I99_RS07210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C0I99_RS07215	COG0372	Belongs to the citrate synthase family
C0I99_RS07225	COG3800	Transcriptional regulator
C0I99_RS07225	COG1396	sequence-specific DNA binding
C0I99_RS07235	COG4770	biotin carboxylase activity
C0I99_RS07240	COG2897	thiosulfate sulfurtransferase activity
C0I99_RS07245	COG0189	ligase activity
C0I99_RS07260	COG0424	maF-like protein
C0I99_RS07270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0I99_RS07275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0I99_RS07295	COG3158	transport of potassium into the cell
C0I99_RS07320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0I99_RS07375	COG3842	ATPase activity
C0I99_RS07405	COG0210	DNA helicase
C0I99_RS07410	COG1201	RNA secondary structure unwinding
C0I99_RS07420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0I99_RS07425	COG1316	TRANSCRIPTIONal
C0I99_RS07465	COG1482	cell wall glycoprotein biosynthetic process
C0I99_RS07495	COG0745	RESPONSE REGULATOR receiver
C0I99_RS07500	COG5002	protein histidine kinase activity
C0I99_RS07505	COG5401	PFAM Sporulation and spore germination
C0I99_RS07515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C0I99_RS07520	COG0653	protein targeting
C0I99_RS07530	COG1011	Hydrolase
C0I99_RS07540	COG1162	GTPase activity
C0I99_RS07545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0I99_RS07585	COG0513	Belongs to the DEAD box helicase family
C0I99_RS07610	COG0210	DNA helicase
C0I99_RS07615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0I99_RS07620	COG2816	NAD+ diphosphatase activity
C0I99_RS07645	COG3480	Lon protease (S16) C-terminal proteolytic domain
C0I99_RS07665	COG1615	UPF0182 protein
C0I99_RS07670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0I99_RS07675	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C0I99_RS07680	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C0I99_RS07740	COG0483	inositol monophosphate 1-phosphatase activity
C0I99_RS07745	COG0483	inositol monophosphate 1-phosphatase activity
C0I99_RS07755	COG2884	Cell division ATP-binding protein ftsE
C0I99_RS07760	COG2177	Part of the ABC transporter FtsEX involved in
C0I99_RS07770	COG3189	MarR family transcriptional regulator
C0I99_RS07790	COG2375	cellular response to nickel ion
C0I99_RS07790	COG1132	(ABC) transporter
C0I99_RS07795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0I99_RS07865	COG1061	Type III restriction enzyme res subunit
C0I99_RS07880	COG1652	LysM domain
C0I99_RS07905	COG2252	PERMEase
C0I99_RS07910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0I99_RS07930	COG0372	Belongs to the citrate synthase family
C0I99_RS07935	COG0545	Peptidyl-prolyl cis-trans isomerase
C0I99_RS07950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0I99_RS07960	COG3757	hydrolase, family 25
C0I99_RS07965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C0I99_RS07980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0I99_RS08000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C0I99_RS08015	COG1218	3'(2'),5'-bisphosphate nucleotidase
C0I99_RS08020	COG1201	RNA secondary structure unwinding
C0I99_RS08025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0I99_RS08030	COG3304	Inner membrane component domain
C0I99_RS08035	COG0586	Pfam SNARE associated Golgi protein
C0I99_RS08045	COG0166	Belongs to the GPI family
C0I99_RS08055	COG1605	Chorismate mutase
C0I99_RS08070	COG1136	(ABC) transporter
C0I99_RS08070	COG0577	efflux transmembrane transporter activity
C0I99_RS08080	COG0739	heme binding
C0I99_RS08100	COG0138	bifunctional purine biosynthesis protein purh
C0I99_RS08125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0I99_RS08140	COG0659	secondary active sulfate transmembrane transporter activity
C0I99_RS08160	COG0745	RESPONSE REGULATOR receiver
C0I99_RS08170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0I99_RS08195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0I99_RS08200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0I99_RS08220	COG2807	transmembrane transport
C0I99_RS08240	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
C0I99_RS08250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0I99_RS08255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0I99_RS08265	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C0I99_RS08275	COG0657	acetylesterase activity
C0I99_RS08290	COG0277	FAD linked oxidase domain protein
C0I99_RS08320	COG0084	hydrolase, TatD family'
C0I99_RS08325	COG3583	domain protein
C0I99_RS08330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0I99_RS08335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C0I99_RS08340	COG0488	(ABC) transporter
C0I99_RS08365	COG2326	polyphosphate kinase activity
C0I99_RS08375	COG0561	phosphatase activity
C0I99_RS08405	COG2409	Drug exporters of the RND superfamily
C0I99_RS08410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0I99_RS08430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C0I99_RS08450	COG0411	ABC transporter
C0I99_RS08460	COG0193	aminoacyl-tRNA hydrolase activity
C0I99_RS08480	COG0193	aminoacyl-tRNA hydrolase activity
C0I99_RS08485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0I99_RS08500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0I99_RS08505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0I99_RS08515	COG2132	Multicopper oxidase
C0I99_RS08530	COG4585	Histidine kinase
C0I99_RS08535	COG2909	trisaccharide binding
C0I99_RS08550	COG1132	(ABC) transporter
C0I99_RS08555	COG1132	(ABC) transporter
C0I99_RS08560	COG0405	Gamma-glutamyltransferase
C0I99_RS08600	COG1309	transcriptional regulator
C0I99_RS08620	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0I99_RS08625	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C0I99_RS08630	COG0531	amino acid
C0I99_RS08640	COG3956	TIGRFAM MazG family protein
C0I99_RS08685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0I99_RS08705	COG2207	Transcriptional regulator
C0I99_RS08720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0I99_RS08730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0I99_RS08740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0I99_RS08745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0I99_RS08800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C0I99_RS08805	COG1914	H( )-stimulated, divalent metal cation uptake system
C0I99_RS08810	COG2188	Transcriptional regulator
C0I99_RS08820	COG0114	fumarate hydratase activity
C0I99_RS08850	COG1960	acyl-CoA dehydrogenase activity
C0I99_RS08865	COG1494	fructose-1,6-bisphosphatase
C0I99_RS08895	COG1570	exodeoxyribonuclease VII activity
C0I99_RS08910	COG0628	permease
C0I99_RS08920	COG0733	neurotransmitter:sodium symporter activity
C0I99_RS08930	COG0012	GTP binding
C0I99_RS08935	COG3549	Plasmid maintenance system killer
C0I99_RS08945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0I99_RS08960	COG3547	Transposase (IS116 IS110 IS902 family)
C0I99_RS08965	COG5001	Diguanylate cyclase
C0I99_RS08965	COG3300	MHYT domain
C0I99_RS09005	COG0656	L-ascorbic acid biosynthetic process
C0I99_RS09010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0I99_RS09015	COG0702	epimerase
C0I99_RS09060	COG0406	alpha-ribazole phosphatase activity
C0I99_RS09075	COG0488	(ABC) transporter
C0I99_RS09085	COG2824	Alkylphosphonate utilization operon protein PhnA
C0I99_RS09095	COG2814	Major facilitator Superfamily
C0I99_RS09105	COG1104	cysteine desulfurase activity
C0I99_RS09115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0I99_RS09130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0I99_RS09135	COG2315	Protein conserved in bacteria
C0I99_RS09140	COG0095	Lipoate-protein ligase
C0I99_RS09150	COG2814	Major facilitator Superfamily
C0I99_RS09160	COG4721	ABC-type cobalt transport system, permease component
C0I99_RS09165	COG1122	ATPase activity
C0I99_RS09180	COG0387	Pfam Sodium calcium exchanger
C0I99_RS09195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0I99_RS09200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C0I99_RS09210	COG2354	Protein conserved in bacteria
C0I99_RS09215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0I99_RS09235	COG5640	endopeptidase activity
C0I99_RS09245	COG3949	Membrane
C0I99_RS09260	COG1217	gtp-binding protein TYPA
C0I99_RS09265	COG0747	negative chemotaxis
C0I99_RS09300	COG2171	N-acyltransferase activity
C0I99_RS09305	COG1113	amino acid transport
C0I99_RS09315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0I99_RS09325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0I99_RS09330	COG0463	Glycosyl transferase, family 2
C0I99_RS09355	COG0297	glycogen (starch) synthase activity
C0I99_RS09365	COG4122	O-methyltransferase activity
C0I99_RS09370	COG1595	DNA-templated transcription, initiation
C0I99_RS09415	COG0567	Dehydrogenase, E1 component
C0I99_RS09415	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0I99_RS09430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0I99_RS09435	COG2272	Belongs to the type-B carboxylesterase lipase family
C0I99_RS09455	COG2814	Major facilitator Superfamily
C0I99_RS09465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C0I99_RS09500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0I99_RS09505	COG4988	ABC transporter
C0I99_RS09510	COG1294	oxidase, subunit
C0I99_RS09515	COG1271	oxidase subunit
C0I99_RS09545	COG1309	transcriptional regulator
C0I99_RS09550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0I99_RS09555	COG1454	alcohol dehydrogenase
C0I99_RS09575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0I99_RS09580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0I99_RS09600	COG0657	acetylesterase activity
C0I99_RS09610	COG2353	YceI-like domain
C0I99_RS09615	COG1846	Transcriptional regulator
C0I99_RS09630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0I99_RS09635	COG2217	Heavy metal translocating P-type atpase
C0I99_RS09645	COG2357	RelA SpoT domain protein
C0I99_RS09660	COG0018	arginyl-trna synthetase
C0I99_RS09665	COG0019	diaminopimelate decarboxylase activity
C0I99_RS09680	COG0460	homoserine dehydrogenase
C0I99_RS09685	COG0083	homoserine kinase activity
C0I99_RS09705	COG1140	nitrate reductase beta subunit
C0I99_RS09720	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0I99_RS09720	COG0315	cyclic pyranopterin monophosphate synthase activity
C0I99_RS09730	COG1253	flavin adenine dinucleotide binding
C0I99_RS09740	COG0746	molybdenum cofactor guanylyltransferase activity
C0I99_RS09750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0I99_RS09795	COG0356	it plays a direct role in the translocation of protons across the membrane
C0I99_RS09800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0I99_RS09805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0I99_RS09815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0I99_RS09820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0I99_RS09830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0I99_RS09840	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C0I99_RS09850	COG0346	lactoylglutathione lyase activity
C0I99_RS09865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0I99_RS09870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0I99_RS09875	COG1116	anion transmembrane transporter activity
C0I99_RS09880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0I99_RS09885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C0I99_RS09890	COG0366	Alpha amylase catalytic
C0I99_RS09895	COG1119	ATPase activity
C0I99_RS09920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C0I99_RS09940	COG1396	sequence-specific DNA binding
C0I99_RS09985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0I99_RS10000	COG0154	amidase activity
C0I99_RS10015	COG0205	6-phosphofructokinase activity
C0I99_RS10020	COG1609	Transcriptional regulator
C0I99_RS10025	COG1129	ABC transporter
C0I99_RS10030	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0I99_RS10035	COG1879	ABC-type sugar transport system periplasmic component
C0I99_RS10040	COG1869	D-ribose catabolic process
C0I99_RS10055	COG0385	Bile acid
C0I99_RS10070	COG0667	Aldo Keto reductase
C0I99_RS10075	COG1279	arginine transmembrane transporter activity
C0I99_RS10080	COG0583	DNA-binding transcription factor activity
C0I99_RS10085	COG0435	Glutathione S-transferase
C0I99_RS10105	COG0129	dihydroxy-acid dehydratase activity
C0I99_RS10115	COG0668	transmembrane transport
C0I99_RS10120	COG0028	Belongs to the TPP enzyme family
C0I99_RS10125	COG0440	acetolactate synthase activity
C0I99_RS10160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0I99_RS10190	COG0473	3-isopropylmalate dehydrogenase activity
C0I99_RS10210	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0I99_RS10225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0I99_RS10230	COG3655	Transcriptional regulator
C0I99_RS10295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0I99_RS10305	COG0058	SHG alpha-glucan phosphorylase activity
C0I99_RS10315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0I99_RS10320	COG0730	response to heat
C0I99_RS10330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0I99_RS10340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0I99_RS10345	COG0066	3-isopropylmalate dehydratase activity
C0I99_RS10350	COG0494	nUDIX hydrolase
C0I99_RS10350	COG0406	alpha-ribazole phosphatase activity
C0I99_RS10365	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0I99_RS10375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C0I99_RS10380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0I99_RS10385	COG1461	Dihydroxyacetone kinase
C0I99_RS10390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0I99_RS10400	COG0742	ribosomal rna small subunit methyltransferase
C0I99_RS10425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0I99_RS10555	COG0656	L-ascorbic acid biosynthetic process
C0I99_RS10570	COG0539	negative regulation of cytoplasmic translation
C0I99_RS10575	COG2190	(PTS) system
C0I99_RS10575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0I99_RS10575	COG1263	PTS System
C0I99_RS10580	COG0237	dephospho-CoA kinase activity
C0I99_RS10605	COG0477	Major facilitator Superfamily
C0I99_RS10610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0I99_RS10640	COG1733	regulation of RNA biosynthetic process
C0I99_RS10645	COG0702	epimerase
C0I99_RS10650	COG3973	AAA domain
C0I99_RS10675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0I99_RS10700	COG4209	transmembrane transport
C0I99_RS10715	COG3842	ATPase activity
C0I99_RS10725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0I99_RS10730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0I99_RS10735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0I99_RS10735	COG0072	phenylalanine-tRNA ligase activity
C0I99_RS10755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0I99_RS10760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0I99_RS10770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0I99_RS10775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0I99_RS10785	COG0137	argininosuccinate synthase activity
C0I99_RS10790	COG0165	Argininosuccinate lyase
C0I99_RS10810	COG2835	tetraacyldisaccharide 4'-kinase activity
C0I99_RS10815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0I99_RS10855	COG0647	UMP catabolic process
C0I99_RS10870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0I99_RS10895	COG0494	nUDIX hydrolase
C0I99_RS10900	COG4974	Belongs to the 'phage' integrase family
C0I99_RS10905	COG0488	(ABC) transporter
C0I99_RS10925	COG2897	thiosulfate sulfurtransferase activity
C0I99_RS10930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0I99_RS10940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0I99_RS10945	COG1160	GTP binding
C0I99_RS10965	COG1132	(ABC) transporter
C0I99_RS10970	COG1132	(ABC) transporter
C0I99_RS10975	COG0428	transporter
C0I99_RS10980	COG0025	NhaP-type Na H and K H
C0I99_RS10995	COG3012	SEC-C Motif Domain Protein
C0I99_RS11005	COG0653	protein targeting
C0I99_RS11010	COG1716	ATPase activity
C0I99_RS11045	COG1253	flavin adenine dinucleotide binding
C0I99_RS11050	COG1253	flavin adenine dinucleotide binding
C0I99_RS11055	COG0513	Belongs to the DEAD box helicase family
C0I99_RS11065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C0I99_RS11085	COG0842	Transport permease protein
C0I99_RS11095	COG3639	organic phosphonate transmembrane transporter activity
C0I99_RS11100	COG3639	organic phosphonate transmembrane transporter activity
C0I99_RS11105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C0I99_RS11120	COG0351	phosphomethylpyrimidine kinase
C0I99_RS11120	COG0352	thiamine-phosphate diphosphorylase activity
C0I99_RS11120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0I99_RS11125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C0I99_RS11130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0I99_RS11140	COG0477	Major facilitator Superfamily
C0I99_RS11145	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C0I99_RS11150	COG1971	Probably functions as a manganese efflux pump
C0I99_RS11170	COG0659	secondary active sulfate transmembrane transporter activity
C0I99_RS11200	COG0463	Glycosyl transferase, family 2
C0I99_RS11255	COG0805	protein transport
C0I99_RS11260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0I99_RS11285	COG4122	O-methyltransferase activity
C0I99_RS11300	COG1362	aminopeptidase activity
C0I99_RS11315	COG2814	Major facilitator Superfamily
C0I99_RS11320	COG1027	Aspartate ammonia-lyase
C0I99_RS11335	COG0546	phosphoglycolate phosphatase activity
C0I99_RS11340	COG1410	methionine synthase
C0I99_RS11340	COG0646	methionine synthase
C0I99_RS11350	COG2072	flavoprotein involved in K transport
C0I99_RS11360	COG0798	PFAM Bile acid sodium symporter
C0I99_RS11365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0I99_RS11370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0I99_RS11385	COG1968	undecaprenyl-diphosphatase activity
C0I99_RS11390	COG0667	Aldo Keto reductase
C0I99_RS11400	COG0167	dihydroorotate dehydrogenase activity
C0I99_RS11425	COG1881	PFAM PEBP family protein
C0I99_RS11430	COG1132	(ABC) transporter
C0I99_RS11435	COG1132	(ABC) transporter
C0I99_RS11470	COG0398	Pfam SNARE associated Golgi protein
C0I99_RS11500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0I99_RS11505	COG3883	PFAM NLP P60 protein
C0I99_RS11505	COG0791	NLP P60 protein
C0I99_RS11515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0I99_RS11520	COG1309	transcriptional regulator
C0I99_RS11540	COG3830	Belongs to the UPF0237 family
C0I99_RS11545	COG2848	UPF0210 protein
C0I99_RS11550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0I99_RS11580	COG0488	(ABC) transporter
C0I99_RS11610	COG0822	iron-sulfur transferase activity
C0I99_RS11620	COG0396	ATPase activity
C0I99_RS11675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0I99_RS11680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0I99_RS11715	COG2423	ornithine cyclodeaminase activity
C0I99_RS11720	COG0004	ammonium transporteR
C0I99_RS11725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0I99_RS11730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C0I99_RS11735	COG0149	triose-phosphate isomerase activity
C0I99_RS11740	COG0126	phosphoglycerate kinase activity
C0I99_RS11745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0I99_RS11750	COG1481	regulation of sporulation
C0I99_RS11755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C0I99_RS11765	COG0322	excinuclease ABC activity
C0I99_RS11815	COG0242	peptide deformylase activity
C0I99_RS11825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0I99_RS11835	COG1758	RNA polymerase activity
C0I99_RS11840	COG0194	GDP metabolic process
C0I99_RS11850	COG0284	orotidine-5'-phosphate decarboxylase activity
C0I99_RS11855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0I99_RS11860	COG0505	Belongs to the CarA family
C0I99_RS11865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0I99_RS11870	COG0540	Belongs to the ATCase OTCase family
C0I99_RS11875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C0I99_RS11900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0I99_RS11910	COG0006	proline dipeptidase activity
C0I99_RS11915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0I99_RS11920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C0I99_RS11925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0I99_RS11940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS11950	COG1120	ATPase activity
C0I99_RS11955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0I99_RS11960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0I99_RS11965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0I99_RS11970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0I99_RS11985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0I99_RS11995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0I99_RS12020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0I99_RS12030	COG1760	l-serine dehydratase
C0I99_RS12035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0I99_RS12040	COG0124	histidyl-tRNA synthetase
C0I99_RS12050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0I99_RS12065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0I99_RS12070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0I99_RS12075	COG0747	negative chemotaxis
C0I99_RS12080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0I99_RS12085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0I99_RS12100	COG0632	four-way junction helicase activity
C0I99_RS12105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0I99_RS12110	COG0217	transcriptional regulatory protein
C0I99_RS12115	COG1946	Acyl-CoA thioesterase
C0I99_RS12130	COG0438	transferase activity, transferring glycosyl groups
C0I99_RS12135	COG1560	Kdo2-lipid A biosynthetic process
C0I99_RS12140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0I99_RS12150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0I99_RS12155	COG2837	iron assimilation
C0I99_RS12160	COG2847	Copper chaperone PCu(A)C
C0I99_RS12225	COG0454	-acetyltransferase
C0I99_RS12225	COG0456	acetyltransferase
C0I99_RS12270	COG1129	ABC transporter
C0I99_RS12400	COG0671	phosphoesterase, PA-phosphatase related
C0I99_RS12400	COG2453	phosphatase
C0I99_RS12410	COG2186	Transcriptional regulator
C0I99_RS12740	COG0542	response to heat
C0I99_RS13245	COG1929	Belongs to the glycerate kinase type-1 family
C0I99_RS13270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0I99_RS13275	COG3253	May function as heme-dependent peroxidase
C0I99_RS13285	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C0I99_RS13290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0I99_RS13295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0I99_RS13305	COG0756	dUTP diphosphatase activity
C0I99_RS13325	COG0483	inositol monophosphate 1-phosphatase activity
C0I99_RS13340	COG2311	Membrane
C0I99_RS13350	COG1061	Type III restriction enzyme res subunit
C0I99_RS13380	COG1321	iron dependent repressor
C0I99_RS13385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0I99_RS13405	COG0583	DNA-binding transcription factor activity
C0I99_RS13415	COG1643	Atp-dependent helicase
C0I99_RS13435	COG1349	DNA-binding transcription factor activity
C0I99_RS13445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0I99_RS13455	COG1105	Belongs to the carbohydrate kinase PfkB family
C0I99_RS13460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0I99_RS13460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0I99_RS13460	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C0I99_RS13475	COG2233	PERMEase
C0I99_RS13480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0I99_RS13495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0I99_RS13500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0I99_RS13510	COG1196	nuclear chromosome segregation
C0I99_RS13530	COG1126	abc transporter atp-binding protein
C0I99_RS13535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0I99_RS13540	COG0765	amino acid transport
C0I99_RS13545	COG0765	amino acid transport
C0I99_RS13550	COG2137	regulation of response to DNA damage stimulus
C0I99_RS13570	COG1268	BioY protein
C0I99_RS13575	COG1122	ATPase activity
C0I99_RS13585	COG1842	Phage shock protein A
C0I99_RS13590	COG1396	sequence-specific DNA binding
C0I99_RS13615	COG1674	ftsk spoiiie
C0I99_RS13625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0I99_RS13630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0I99_RS13635	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C0I99_RS13640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0I99_RS13650	COG1185	polyribonucleotide nucleotidyltransferase activity
C0I99_RS13670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0I99_RS13680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C0I99_RS13690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0I99_RS13695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0I99_RS13700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0I99_RS13715	COG0779	Required for maturation of 30S ribosomal subunits
C0I99_RS13725	COG4166	transmembrane transport
C0I99_RS13730	COG0601	transmembrane transport
C0I99_RS13735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0I99_RS13740	COG4172	Belongs to the ABC transporter superfamily
C0I99_RS13750	COG0442	prolyl-tRNA aminoacylation
C0I99_RS13755	COG3022	response to hydroperoxide
C0I99_RS13770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0I99_RS13770	COG1648	precorrin-2 dehydrogenase activity
C0I99_RS13775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0I99_RS13825	COG2197	response regulator
C0I99_RS13830	COG3850	Histidine kinase
C0I99_RS13835	COG0577	efflux transmembrane transporter activity
C0I99_RS13840	COG1136	(ABC) transporter
C0I99_RS13840	COG0577	efflux transmembrane transporter activity
C0I99_RS13845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0I99_RS13850	COG0750	zinc metalloprotease
C0I99_RS13855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0I99_RS13870	COG1131	(ABC) transporter
C0I99_RS13875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0I99_RS13890	COG0442	prolyl-tRNA aminoacylation
C0I99_RS13895	COG3022	response to hydroperoxide
C0I99_RS13910	COG1648	precorrin-2 dehydrogenase activity
C0I99_RS13910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0I99_RS13915	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0I99_RS13965	COG2197	response regulator
C0I99_RS13970	COG3850	Histidine kinase
C0I99_RS13975	COG0577	efflux transmembrane transporter activity
C0I99_RS13980	COG0577	efflux transmembrane transporter activity
C0I99_RS13980	COG1136	(ABC) transporter
C0I99_RS13985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0I99_RS13990	COG0750	zinc metalloprotease
C0I99_RS13995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0I99_RS14010	COG1131	(ABC) transporter
C0I99_RS14015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0I99_RS14030	COG0233	cytoplasmic translational termination
C0I99_RS14040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0I99_RS14045	COG0052	Belongs to the universal ribosomal protein uS2 family
C0I99_RS14055	COG4974	Belongs to the 'phage' integrase family
C0I99_RS14065	COG0606	chelatase, subunit chli
C0I99_RS14070	COG0792	nuclease activity
C0I99_RS14080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0I99_RS14085	COG0681	Belongs to the peptidase S26 family
C0I99_RS14095	COG0335	large ribosomal subunit rRNA binding
C0I99_RS14100	COG0352	thiamine-phosphate diphosphorylase activity
C0I99_RS14105	COG2022	thiamine diphosphate biosynthetic process
C0I99_RS14105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0I99_RS14115	COG2022	thiamine diphosphate biosynthetic process
C0I99_RS14120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0I99_RS14130	COG1609	Transcriptional regulator
C0I99_RS14135	COG0471	metal ion transport
C0I99_RS14140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0I99_RS14155	COG0336	Belongs to the RNA methyltransferase TrmD family
C0I99_RS14165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0I99_RS14200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C0I99_RS14225	COG1196	nuclear chromosome segregation
C0I99_RS14230	COG1254	Belongs to the acylphosphatase family
C0I99_RS14275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0I99_RS14280	COG0571	ribonuclease III activity
C0I99_RS14295	COG1132	(ABC) transporter
C0I99_RS14300	COG1132	(ABC) transporter
C0I99_RS14305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0I99_RS14310	COG1929	Belongs to the glycerate kinase type-1 family
C0I99_RS14340	COG0058	SHG alpha-glucan phosphorylase activity
C0I99_RS14345	COG2514	catechol 2,3-dioxygenase activity
C0I99_RS14350	COG0469	pyruvate kinase activity
C0I99_RS14360	COG0134	indole-3-glycerol-phosphate synthase activity
C0I99_RS14370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0I99_RS14380	COG0483	inositol monophosphate 1-phosphatase activity
C0I99_RS14385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0I99_RS14390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0I99_RS14410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0I99_RS14415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0I99_RS14445	COG2264	protein methyltransferase activity
C0I99_RS14455	COG0673	inositol 2-dehydrogenase activity
C0I99_RS14460	COG1609	Transcriptional regulator
C0I99_RS14465	COG1120	ATPase activity
C0I99_RS14470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0I99_RS14530	COG1739	Uncharacterized protein family UPF0029
C0I99_RS14540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0I99_RS14575	COG1028	Short-chain dehydrogenase reductase Sdr
C0I99_RS14580	COG0019	diaminopimelate decarboxylase activity
C0I99_RS14600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0I99_RS14610	COG0488	(ABC) transporter
C0I99_RS14620	COG0252	asparaginase activity
C0I99_RS14630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0I99_RS14650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0I99_RS14660	COG3599	regulation of cell shape
C0I99_RS14670	COG1799	cell septum assembly
C0I99_RS14675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C0I99_RS14680	COG1496	oxidoreductase activity
C0I99_RS14685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0I99_RS14690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0I99_RS14695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0I99_RS14700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0I99_RS14710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0I99_RS14715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0I99_RS14725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0I99_RS14730	COG0768	penicillin binding
C0I99_RS14740	COG0275	rRNA processing
C0I99_RS14760	COG0456	acetyltransferase
C0I99_RS14770	COG0142	geranyltranstransferase activity
C0I99_RS14785	COG0515	serine threonine protein kinase
C0I99_RS14785	COG2815	serine threonine protein kinase
C0I99_RS14790	COG5650	phosphatidylinositol metabolic process
C0I99_RS14800	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C0I99_RS14835	COG1940	carbohydrate kinase activity
C0I99_RS14840	COG0438	transferase activity, transferring glycosyl groups
C0I99_RS14850	COG0791	NLP P60 protein
C0I99_RS14855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0I99_RS14860	COG0723	plastoquinol--plastocyanin reductase activity
C0I99_RS14865	COG2010	Cytochrome c
C0I99_RS14870	COG1845	cytochrome c oxidase, subunit III
C0I99_RS14885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0I99_RS14915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C0I99_RS14925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0I99_RS14930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0I99_RS14940	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0I99_RS14960	COG2985	domain, Protein
C0I99_RS14960	COG0569	domain protein
C0I99_RS14965	COG2826	transposase and inactivated derivatives, IS30 family
C0I99_RS14975	COG0174	glutamine synthetase
C0I99_RS14995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0I99_RS15005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0I99_RS15035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0I99_RS15040	COG0174	glutamine synthetase
C0I99_RS15065	COG0557	exoribonuclease II activity
C0I99_RS15085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0I99_RS15085	COG3323	Protein of unknown function (DUF1653)
C0I99_RS15135	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0I99_RS15165	COG0596	Alpha beta hydrolase
C0I99_RS15170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0I99_RS15245	COG3387	PFAM Glycoside hydrolase 15-related
C0I99_RS15255	COG0358	DNA primase activity
C0I99_RS15270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0I99_RS15280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C0I99_RS15305	COG0423	glycine-tRNA ligase activity
C0I99_RS15330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0I99_RS15350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C0I99_RS15365	COG0484	heat shock protein binding
C0I99_RS15405	COG1132	(ABC) transporter
C0I99_RS15430	COG0366	Alpha amylase catalytic
C0I99_RS15440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C0I99_RS15465	COG1114	Component of the transport system for branched-chain amino acids
C0I99_RS15470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0I99_RS15475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0I99_RS15490	COG0277	FAD linked oxidase domain protein
C0I99_RS15490	COG0247	lactate metabolic process
C0I99_RS15515	COG0747	negative chemotaxis
C0I99_RS15520	COG0601	transmembrane transport
C0I99_RS15525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0I99_RS15540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0I99_RS15550	COG0385	Bile acid
C0I99_RS15555	COG0676	glucose-6-phosphate 1-epimerase activity
C0I99_RS15560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0I99_RS15565	COG2224	Isocitrate lyase
C0I99_RS15580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0I99_RS15610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C0I99_RS15620	COG0481	GTPase activity
C0I99_RS15635	COG1280	lysine exporter protein (LysE YggA)
C0I99_RS15660	COG1307	EDD domain protein, DegV family
C0I99_RS15665	COG0406	alpha-ribazole phosphatase activity
C0I99_RS15675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0I99_RS15690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0I99_RS15695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0I99_RS15700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0I99_RS15735	COG1530	ribonuclease E activity
C0I99_RS15790	COG0285	dihydrofolate synthase activity
C0I99_RS15795	COG0525	valine-tRNA ligase activity
C0I99_RS15805	COG0443	Heat shock 70 kDa protein
C0I99_RS15815	COG0039	L-malate dehydrogenase activity
C0I99_RS15820	COG1309	transcriptional regulator
C0I99_RS15840	COG2814	Major facilitator Superfamily