locus-tag	class	description
JK_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JK_RS00010	COG0592	DNA-directed DNA polymerase activity
JK_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JK_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JK_RS00025	COG0187	DNA topoisomerase II activity
JK_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JK_RS00060	COG3266	domain, Protein
JK_RS00080	COG2826	transposase and inactivated derivatives, IS30 family
JK_RS00110	COG2826	transposase and inactivated derivatives, IS30 family
JK_RS00130	COG1595	DNA-templated transcription, initiation
JK_RS00160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JK_RS00160	COG0512	Glutamine amidotransferase of anthranilate synthase
JK_RS00190	COG0515	serine threonine protein kinase
JK_RS00190	COG2815	serine threonine protein kinase
JK_RS00195	COG0515	serine threonine protein kinase
JK_RS00200	COG0768	penicillin binding
JK_RS00215	COG1716	ATPase activity
JK_RS00220	COG1716	ATPase activity
JK_RS00220	COG1716	ATPase activity
JK_RS00245	COG3634	alkyl hydroperoxide reductase activity
JK_RS00265	COG1652	LysM domain
JK_RS00280	COG2094	Belongs to the DNA glycosylase MPG family
JK_RS00310	COG0393	Putative heavy-metal-binding
JK_RS00320	COG3328	transposase activity
JK_RS00330	COG0494	nUDIX hydrolase
JK_RS00335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JK_RS00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JK_RS00365	COG3189	MarR family transcriptional regulator
JK_RS00385	COG0519	Catalyzes the synthesis of GMP from XMP
JK_RS00390	COG0446	pyridine nucleotide-disulphide oxidoreductase
JK_RS00390	COG1902	pentaerythritol trinitrate reductase activity
JK_RS00395	COG0070	glutamate synthase
JK_RS00395	COG0069	glutamate synthase activity
JK_RS00395	COG0067	glutamate synthase
JK_RS00405	COG1280	lysine exporter protein (LysE YggA)
JK_RS00410	COG2501	S4 domain
JK_RS00420	COG3590	peptidase
JK_RS00435	COG3757	hydrolase, family 25
JK_RS00435	COG3409	Peptidoglycan-binding domain 1 protein
JK_RS00465	COG1131	(ABC) transporter
JK_RS00495	COG3328	transposase activity
JK_RS00510	COG0477	Major facilitator Superfamily
JK_RS00515	COG0564	pseudouridine synthase activity
JK_RS00530	COG0706	membrane insertase activity
JK_RS00570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JK_RS00585	COG0039	L-malate dehydrogenase activity
JK_RS00600	COG1316	TRANSCRIPTIONal
JK_RS00635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JK_RS00645	COG0561	phosphatase activity
JK_RS00675	COG1216	Glycosyl transferase, family 2
JK_RS00680	COG0671	phosphoesterase, PA-phosphatase related
JK_RS00685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JK_RS00695	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JK_RS00695	COG5479	isomerase activity
JK_RS00705	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
JK_RS00710	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS00715	COG3321	synthase
JK_RS00715	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JK_RS00715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JK_RS00720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JK_RS00740	COG2814	Major facilitator Superfamily
JK_RS00745	COG0583	DNA-binding transcription factor activity
JK_RS00770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JK_RS00785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
JK_RS00795	COG3328	transposase activity
JK_RS00810	COG2391	methyltransferase activity
JK_RS00825	COG1250	3-hydroxyacyl-CoA dehydrogenase
JK_RS00825	COG1024	Enoyl-CoA hydratase
JK_RS00830	COG0183	Belongs to the thiolase family
JK_RS00835	COG0500	methyltransferase
JK_RS00840	COG0438	transferase activity, transferring glycosyl groups
JK_RS00855	COG4981	capsule polysaccharide biosynthetic process
JK_RS00855	COG4981	capsule polysaccharide biosynthetic process
JK_RS00865	COG0589	response to stress
JK_RS00870	COG1472	Belongs to the glycosyl hydrolase 3 family
JK_RS00890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JK_RS00895	COG0717	Belongs to the dCTP deaminase family
JK_RS00910	COG0247	lactate metabolic process
JK_RS00910	COG2181	nitrate reductase activity
JK_RS00920	COG0443	Heat shock 70 kDa protein
JK_RS00940	COG0484	heat shock protein binding
JK_RS00945	COG0789	Transcriptional regulator
JK_RS00950	COG0531	amino acid
JK_RS00955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JK_RS00960	COG0659	secondary active sulfate transmembrane transporter activity
JK_RS00965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JK_RS00985	COG0543	2 iron, 2 sulfur cluster binding
JK_RS00985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JK_RS00990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JK_RS00995	COG1960	acyl-CoA dehydrogenase activity
JK_RS01030	COG0542	response to heat
JK_RS01050	COG2897	thiosulfate sulfurtransferase activity
JK_RS01070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JK_RS01070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JK_RS01075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JK_RS01080	COG0509	glycine decarboxylation via glycine cleavage system
JK_RS01090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JK_RS01105	COG0191	fructose-bisphosphate aldolase activity
JK_RS01120	COG4129	membrane
JK_RS01135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JK_RS01140	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS01145	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS01150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JK_RS01155	COG1780	Probably involved in ribonucleotide reductase function
JK_RS01170	COG1960	acyl-CoA dehydrogenase activity
JK_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
JK_RS01185	COG1309	transcriptional regulator
JK_RS01195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JK_RS01210	COG1122	ATPase activity
JK_RS01220	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JK_RS01225	COG1054	Belongs to the UPF0176 family
JK_RS01230	COG2153	protein acetylation
JK_RS01240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JK_RS01270	COG0730	response to heat
JK_RS01275	COG0280	phosphate acetyltransferase
JK_RS01280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JK_RS01285	COG0515	serine threonine protein kinase
JK_RS01290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JK_RS01300	COG1131	(ABC) transporter
JK_RS01315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JK_RS01325	COG0456	acetyltransferase
JK_RS01325	COG1846	Transcriptional regulator
JK_RS01330	COG0242	peptide deformylase activity
JK_RS01345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JK_RS01360	COG0459	protein refolding
JK_RS01365	COG2326	polyphosphate kinase activity
JK_RS01380	COG0425	Belongs to the sulfur carrier protein TusA family
JK_RS01380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JK_RS01385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JK_RS01390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JK_RS01395	COG2027	D-alanyl-D-alanine carboxypeptidase
JK_RS01400	COG0037	tRNA processing
JK_RS01410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JK_RS01420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JK_RS01430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JK_RS01450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JK_RS01455	COG2017	converts alpha-aldose to the beta-anomer
JK_RS01475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JK_RS01480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JK_RS01490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JK_RS01495	COG1960	acyl-CoA dehydrogenase activity
JK_RS01500	COG1960	acyl-CoA dehydrogenase activity
JK_RS01505	COG0351	phosphomethylpyrimidine kinase
JK_RS01505	COG0352	thiamine-phosphate diphosphorylase activity
JK_RS01505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JK_RS01510	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS01515	COG0542	response to heat
JK_RS01525	COG1114	Component of the transport system for branched-chain amino acids
JK_RS01545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JK_RS01550	COG2847	Copper chaperone PCu(A)C
JK_RS01555	COG1329	Transcriptional regulator
JK_RS01560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JK_RS01565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JK_RS01585	COG0179	Fumarylacetoacetate (FAA) hydrolase
JK_RS01590	COG0215	cysteine-tRNA ligase activity
JK_RS01615	COG1120	ATPase activity
JK_RS01635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JK_RS01650	COG2272	Belongs to the type-B carboxylesterase lipase family
JK_RS01655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JK_RS01660	COG1121	(ABC) transporter
JK_RS01670	COG1609	Transcriptional regulator
JK_RS01720	COG3328	transposase activity
JK_RS01740	COG0745	RESPONSE REGULATOR receiver
JK_RS01745	COG5002	protein histidine kinase activity
JK_RS01745	COG3850	Histidine kinase
JK_RS01750	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS01760	COG0537	adenosine 5'-monophosphoramidase activity
JK_RS01765	COG0151	Belongs to the GarS family
JK_RS01770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JK_RS01775	COG0569	domain protein
JK_RS01780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JK_RS01785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JK_RS01800	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JK_RS01805	COG0047	phosphoribosylformylglycinamidine synthase activity
JK_RS01810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JK_RS01815	COG1607	acyl-coa hydrolase
JK_RS01830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JK_RS01840	COG1132	(ABC) transporter
JK_RS01845	COG1132	(ABC) transporter
JK_RS01870	COG1968	undecaprenyl-diphosphatase activity
JK_RS01875	COG0215	cysteine-tRNA ligase activity
JK_RS01910	COG4044	May play a role in the intracellular transport of hydrophobic ligands
JK_RS01920	COG0456	acetyltransferase
JK_RS01935	COG0581	inorganic phosphate transmembrane transporter activity
JK_RS01940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JK_RS01945	COG3265	gluconokinase activity
JK_RS02025	COG1045	serine acetyltransferase
JK_RS02030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JK_RS02045	COG2197	response regulator
JK_RS02050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JK_RS02070	COG1136	(ABC) transporter
JK_RS02085	COG1914	H( )-stimulated, divalent metal cation uptake system
JK_RS02090	COG4336	lyase activity
JK_RS02100	COG4770	biotin carboxylase activity
JK_RS02105	COG1984	allophanate hydrolase subunit 2
JK_RS02110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JK_RS02120	COG1061	Type III restriction enzyme res subunit
JK_RS02150	COG1652	LysM domain
JK_RS02155	COG1278	Cold shock
JK_RS02175	COG2252	PERMEase
JK_RS02180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JK_RS02200	COG0372	Belongs to the citrate synthase family
JK_RS02205	COG0545	Peptidyl-prolyl cis-trans isomerase
JK_RS02215	COG4152	abc transporter atp-binding protein
JK_RS02220	COG0656	L-ascorbic acid biosynthetic process
JK_RS02240	COG2801	Transposase and inactivated derivatives
JK_RS02240	COG3415	Transposase
JK_RS02255	COG1129	ABC transporter
JK_RS02260	COG2375	cellular response to nickel ion
JK_RS02260	COG1132	(ABC) transporter
JK_RS02265	COG1132	(ABC) transporter
JK_RS02275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JK_RS02280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JK_RS02285	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JK_RS02290	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JK_RS02295	COG1218	3'(2'),5'-bisphosphate nucleotidase
JK_RS02300	COG1201	RNA secondary structure unwinding
JK_RS02330	COG0166	Belongs to the GPI family
JK_RS02340	COG0483	inositol monophosphate 1-phosphatase activity
JK_RS02345	COG0483	inositol monophosphate 1-phosphatase activity
JK_RS02355	COG1012	belongs to the aldehyde dehydrogenase family
JK_RS02360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JK_RS02365	COG2884	Cell division ATP-binding protein ftsE
JK_RS02370	COG2177	Part of the ABC transporter FtsEX involved in
JK_RS02375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JK_RS02385	COG3328	transposase activity
JK_RS02400	COG2056	Na+-H+ antiporter family
JK_RS02410	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS02420	COG1115	amino acid carrier protein
JK_RS02445	COG2963	transposase activity
JK_RS02450	COG2801	Transposase and inactivated derivatives
JK_RS02460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JK_RS02465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JK_RS02480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JK_RS02485	COG1528	Iron-storage protein
JK_RS02495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JK_RS02500	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS02505	COG0560	Phosphoserine phosphatase
JK_RS02505	COG3830	Belongs to the UPF0237 family
JK_RS02510	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS02525	COG0443	Heat shock 70 kDa protein
JK_RS02550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JK_RS02555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JK_RS02570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JK_RS02575	COG1234	tRNA 3'-trailer cleavage
JK_RS02580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JK_RS02585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JK_RS02625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JK_RS02675	COG1376	ErfK ybiS ycfS ynhG family protein
JK_RS02685	COG2608	mercury ion transmembrane transporter activity
JK_RS02700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JK_RS02705	COG0300	oxidoreductase activity
JK_RS02720	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS02770	COG3415	Transposase
JK_RS02770	COG2801	Transposase and inactivated derivatives
JK_RS02775	COG2801	Transposase and inactivated derivatives
JK_RS02775	COG3415	Transposase
JK_RS02785	COG3328	transposase activity
JK_RS02790	COG3336	cytochrome c oxidase
JK_RS02815	COG0730	response to heat
JK_RS02830	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JK_RS02855	COG0544	peptidyl-prolyl cis-trans isomerase activity
JK_RS02860	COG0740	serine-type endopeptidase activity
JK_RS02865	COG0740	serine-type endopeptidase activity
JK_RS02870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JK_RS02880	COG0039	L-malate dehydrogenase activity
JK_RS02885	COG0657	acetylesterase activity
JK_RS02890	COG0525	valine-tRNA ligase activity
JK_RS02895	COG0285	dihydrofolate synthase activity
JK_RS02910	COG0105	UTP biosynthetic process
JK_RS02920	COG1530	ribonuclease E activity
JK_RS02925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JK_RS02930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JK_RS02935	COG1120	ATPase activity
JK_RS02940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS02950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JK_RS02955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JK_RS02965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JK_RS02975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JK_RS02980	COG0799	negative regulation of ribosome biogenesis
JK_RS02985	COG0406	alpha-ribazole phosphatase activity
JK_RS02990	COG1307	EDD domain protein, DegV family
JK_RS03015	COG0268	Binds directly to 16S ribosomal RNA
JK_RS03025	COG0481	GTPase activity
JK_RS03075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JK_RS03085	COG3237	CsbD-like
JK_RS03090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JK_RS03095	COG1132	(ABC) transporter
JK_RS03110	COG0339	signal peptide processing
JK_RS03125	COG1022	Amp-dependent synthetase and ligase
JK_RS03140	COG1420	regulation of RNA biosynthetic process
JK_RS03145	COG0484	heat shock protein binding
JK_RS03160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JK_RS03185	COG1381	Involved in DNA repair and RecF pathway recombination
JK_RS03190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JK_RS03205	COG0423	glycine-tRNA ligase activity
JK_RS03215	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS03235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JK_RS03245	COG2826	transposase and inactivated derivatives, IS30 family
JK_RS03275	COG2826	transposase and inactivated derivatives, IS30 family
JK_RS03290	COG0358	DNA primase activity
JK_RS03305	COG3328	transposase activity
JK_RS03335	COG1937	Protein conserved in bacteria
JK_RS03375	COG1518	maintenance of DNA repeat elements
JK_RS03415	COG2963	transposase activity
JK_RS03420	COG2801	Transposase and inactivated derivatives
JK_RS03430	COG1126	abc transporter atp-binding protein
JK_RS03435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JK_RS03440	COG0765	amino acid transport
JK_RS03445	COG0765	amino acid transport
JK_RS03465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JK_RS03525	COG2149	membrane
JK_RS03540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JK_RS03545	COG0174	glutamine synthetase
JK_RS03550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JK_RS03560	COG2223	nitrite transmembrane transporter activity
JK_RS03580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JK_RS03585	COG0662	Cupin 2, conserved barrel domain protein
JK_RS03595	COG3949	Membrane
JK_RS03605	COG1511	domain protein
JK_RS03625	COG2801	Transposase and inactivated derivatives
JK_RS03630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JK_RS03650	COG2856	Zn peptidase
JK_RS03665	COG0174	glutamine synthetase
JK_RS03680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JK_RS03685	COG0321	lipoyl(octanoyl) transferase activity
JK_RS03695	COG0508	dehydrogenase complex catalyzes the overall conversion of
JK_RS03710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JK_RS03715	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JK_RS03735	COG0028	Belongs to the TPP enzyme family
JK_RS03750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JK_RS03770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JK_RS03780	COG0791	NLP P60 protein
JK_RS03790	COG0438	transferase activity, transferring glycosyl groups
JK_RS03815	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JK_RS03820	COG2815	serine threonine protein kinase
JK_RS03820	COG0515	serine threonine protein kinase
JK_RS03840	COG0142	geranyltranstransferase activity
JK_RS03865	COG2001	Belongs to the MraZ family
JK_RS03870	COG0275	rRNA processing
JK_RS03880	COG0768	penicillin binding
JK_RS03885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JK_RS03895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JK_RS03900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JK_RS03910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JK_RS03915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JK_RS03920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JK_RS03925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JK_RS03930	COG1496	oxidoreductase activity
JK_RS03935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JK_RS03940	COG1799	cell septum assembly
JK_RS03950	COG3599	regulation of cell shape
JK_RS03960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JK_RS03970	COG0252	asparaginase activity
JK_RS03985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JK_RS04020	COG0469	pyruvate kinase activity
JK_RS04030	COG1739	Uncharacterized protein family UPF0029
JK_RS04095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JK_RS04100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JK_RS04105	COG0131	Imidazoleglycerol-phosphate dehydratase
JK_RS04115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JK_RS04120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JK_RS04125	COG0483	inositol monophosphate 1-phosphatase activity
JK_RS04130	COG0107	imidazoleglycerol-phosphate synthase activity
JK_RS04135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JK_RS04140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JK_RS04150	COG0134	indole-3-glycerol-phosphate synthase activity
JK_RS04160	COG0159	tryptophan synthase activity
JK_RS04165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JK_RS04170	COG0469	pyruvate kinase activity
JK_RS04175	COG1473	amidohydrolase
JK_RS04195	COG1126	abc transporter atp-binding protein
JK_RS04200	COG0765	amino acid transport
JK_RS04205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JK_RS04240	COG2801	Transposase and inactivated derivatives
JK_RS04240	COG3415	Transposase
JK_RS04270	COG0539	negative regulation of cytoplasmic translation
JK_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
JK_RS04285	COG0183	Belongs to the thiolase family
JK_RS04300	COG0237	dephospho-CoA kinase activity
JK_RS04320	COG3973	AAA domain
JK_RS04345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JK_RS04350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JK_RS04355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JK_RS04365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JK_RS04370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JK_RS04375	COG0072	phenylalanine-tRNA ligase activity
JK_RS04375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JK_RS04380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JK_RS04385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JK_RS04390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JK_RS04395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JK_RS04410	COG0137	argininosuccinate synthase activity
JK_RS04415	COG0165	Argininosuccinate lyase
JK_RS04425	COG2022	thiamine diphosphate biosynthetic process
JK_RS04435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JK_RS04445	COG0352	thiamine-phosphate diphosphorylase activity
JK_RS04450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JK_RS04470	COG2835	tetraacyldisaccharide 4'-kinase activity
JK_RS04475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JK_RS04500	COG0647	UMP catabolic process
JK_RS04510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JK_RS04540	COG0504	CTP synthase activity
JK_RS04545	COG0494	nUDIX hydrolase
JK_RS04550	COG4974	Belongs to the 'phage' integrase family
JK_RS04560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JK_RS04575	COG1160	GTP binding
JK_RS04585	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS04595	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JK_RS04605	COG2985	domain, Protein
JK_RS04605	COG0569	domain protein
JK_RS04620	COG2197	response regulator
JK_RS04625	COG4585	Histidine kinase
JK_RS04635	COG1131	(ABC) transporter
JK_RS04650	COG2161	toxin-antitoxin pair type II binding
JK_RS04690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JK_RS04700	COG0653	protein targeting
JK_RS04705	COG1716	ATPase activity
JK_RS04740	COG1253	flavin adenine dinucleotide binding
JK_RS04745	COG0513	Belongs to the DEAD box helicase family
JK_RS04750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JK_RS04760	COG0446	pyridine nucleotide-disulphide oxidoreductase
JK_RS04780	COG4221	oxidoreductase activity
JK_RS04790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JK_RS04800	COG0477	Major facilitator Superfamily
JK_RS04820	COG2723	6-phospho-beta-galactosidase activity
JK_RS04845	COG0463	Glycosyl transferase, family 2
JK_RS04865	COG0300	oxidoreductase activity
JK_RS04875	COG0805	protein transport
JK_RS04880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JK_RS04895	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JK_RS04905	COG4122	O-methyltransferase activity
JK_RS04910	COG1222	aaa ATPase
JK_RS04925	COG1027	Aspartate ammonia-lyase
JK_RS04930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JK_RS04935	COG0140	phosphoribosyl-ATP diphosphatase activity
JK_RS04950	COG0215	cysteine-tRNA ligase activity
JK_RS04955	COG1968	undecaprenyl-diphosphatase activity
JK_RS05010	COG0791	NLP P60 protein
JK_RS05010	COG3883	PFAM NLP P60 protein
JK_RS05020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JK_RS05025	COG1309	transcriptional regulator
JK_RS05030	COG3830	Belongs to the UPF0237 family
JK_RS05035	COG2848	UPF0210 protein
JK_RS05060	COG0488	(ABC) transporter
JK_RS05075	COG0822	iron-sulfur transferase activity
JK_RS05085	COG0396	ATPase activity
JK_RS05110	COG1131	(ABC) transporter
JK_RS05130	COG0109	protoheme IX farnesyltransferase activity
JK_RS05140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JK_RS05160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JK_RS05175	COG0126	phosphoglycerate kinase activity
JK_RS05180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JK_RS05185	COG1481	regulation of sporulation
JK_RS05190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JK_RS05195	COG1660	Displays ATPase and GTPase activities
JK_RS05200	COG0322	excinuclease ABC activity
JK_RS05210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JK_RS05240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JK_RS05245	COG0242	peptide deformylase activity
JK_RS05255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JK_RS05265	COG1758	RNA polymerase activity
JK_RS05270	COG0194	GDP metabolic process
JK_RS05280	COG0284	orotidine-5'-phosphate decarboxylase activity
JK_RS05285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JK_RS05295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JK_RS05300	COG0540	Belongs to the ATCase OTCase family
JK_RS05310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JK_RS05315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JK_RS05320	COG0006	proline dipeptidase activity
JK_RS05325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JK_RS05330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JK_RS05335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JK_RS05340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JK_RS05350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JK_RS05360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JK_RS05365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JK_RS05380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JK_RS05395	COG0737	Belongs to the 5'-nucleotidase family
JK_RS05400	COG0124	histidyl-tRNA synthetase
JK_RS05405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JK_RS05415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JK_RS05420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JK_RS05430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JK_RS05440	COG1862	Preprotein translocase
JK_RS05445	COG2255	four-way junction helicase activity
JK_RS05450	COG0632	four-way junction helicase activity
JK_RS05455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JK_RS05460	COG0217	transcriptional regulatory protein
JK_RS05465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JK_RS05470	COG1946	Acyl-CoA thioesterase
JK_RS05475	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JK_RS05485	COG0438	transferase activity, transferring glycosyl groups
JK_RS05490	COG1560	Kdo2-lipid A biosynthetic process
JK_RS05495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JK_RS05505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JK_RS05510	COG2837	iron assimilation
JK_RS05570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JK_RS05580	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JK_RS05595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JK_RS05600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JK_RS05605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JK_RS05620	COG0756	dUTP diphosphatase activity
JK_RS05655	COG1061	Type III restriction enzyme res subunit
JK_RS05670	COG2890	protein-(glutamine-N5) methyltransferase activity
JK_RS05675	COG1490	D-aminoacyl-tRNA deacylase activity
JK_RS05690	COG1321	iron dependent repressor
JK_RS05725	COG1643	Atp-dependent helicase
JK_RS05730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JK_RS05735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JK_RS05745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JK_RS05755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JK_RS05760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JK_RS05765	COG1196	nuclear chromosome segregation
JK_RS05775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JK_RS05785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JK_RS05795	COG1268	BioY protein
JK_RS05800	COG1122	ATPase activity
JK_RS05805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JK_RS05810	COG1842	Phage shock protein A
JK_RS05815	COG1396	sequence-specific DNA binding
JK_RS05820	COG1546	Belongs to the CinA family
JK_RS05820	COG1058	Belongs to the CinA family
JK_RS05835	COG1674	ftsk spoiiie
JK_RS05845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JK_RS05850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JK_RS05860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JK_RS05865	COG1185	polyribonucleotide nucleotidyltransferase activity
JK_RS05870	COG2963	transposase activity
JK_RS05875	COG2801	Transposase and inactivated derivatives
JK_RS05880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JK_RS05905	COG0534	Mate efflux family protein
JK_RS05910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JK_RS05915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JK_RS05925	COG0779	Required for maturation of 30S ribosomal subunits
JK_RS05935	COG0442	prolyl-tRNA aminoacylation
JK_RS05940	COG3022	response to hydroperoxide
JK_RS05950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JK_RS05955	COG0579	oxidoreductase
JK_RS06005	COG2197	response regulator
JK_RS06010	COG4585	Histidine kinase
JK_RS06015	COG0577	efflux transmembrane transporter activity
JK_RS06020	COG1136	(ABC) transporter
JK_RS06020	COG0577	efflux transmembrane transporter activity
JK_RS06025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JK_RS06030	COG0750	zinc metalloprotease
JK_RS06035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JK_RS06045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JK_RS06060	COG0233	cytoplasmic translational termination
JK_RS06065	COG0528	UMP kinase activity
JK_RS06070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JK_RS06075	COG0052	Belongs to the universal ribosomal protein uS2 family
JK_RS06085	COG4974	Belongs to the 'phage' integrase family
JK_RS06100	COG0792	nuclease activity
JK_RS06110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JK_RS06115	COG0681	Belongs to the peptidase S26 family
JK_RS06120	COG0335	large ribosomal subunit rRNA binding
JK_RS06130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JK_RS06135	COG1012	belongs to the aldehyde dehydrogenase family
JK_RS06140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JK_RS06145	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JK_RS06150	COG0336	Belongs to the RNA methyltransferase TrmD family
JK_RS06155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JK_RS06160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JK_RS06165	COG0228	four-way junction DNA binding
JK_RS06195	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JK_RS06200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JK_RS06200	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JK_RS06220	COG1115	amino acid carrier protein
JK_RS06225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JK_RS06230	COG0571	ribonuclease III activity
JK_RS06245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JK_RS06250	COG0742	ribosomal rna small subunit methyltransferase
JK_RS06255	COG4770	biotin carboxylase activity
JK_RS06265	COG1461	Dihydroxyacetone kinase
JK_RS06270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JK_RS06275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JK_RS06285	COG1181	Belongs to the D-alanine--D-alanine ligase family
JK_RS06290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JK_RS06295	COG0494	nUDIX hydrolase
JK_RS06295	COG0406	alpha-ribazole phosphatase activity
JK_RS06300	COG0066	3-isopropylmalate dehydratase activity
JK_RS06305	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JK_RS06365	COG2801	Transposase and inactivated derivatives
JK_RS06385	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JK_RS06390	COG3421	Type III restriction
JK_RS06400	COG3104	oligopeptide transport
JK_RS06410	COG2801	Transposase and inactivated derivatives
JK_RS06435	COG0419	ATPase involved in DNA repair
JK_RS06445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JK_RS06465	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS06495	COG2801	Transposase and inactivated derivatives
JK_RS06495	COG3415	Transposase
JK_RS06515	COG0058	SHG alpha-glucan phosphorylase activity
JK_RS06525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JK_RS06535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JK_RS06555	COG3340	Belongs to the peptidase S51 family
JK_RS06560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JK_RS06595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JK_RS06610	COG3622	Belongs to the hyi family
JK_RS06620	COG0179	Fumarylacetoacetate (FAA) hydrolase
JK_RS06630	COG0473	3-isopropylmalate dehydrogenase activity
JK_RS06635	COG1131	(ABC) transporter
JK_RS06645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JK_RS06650	COG0523	cobalamin synthesis protein
JK_RS06655	COG1120	ATPase activity
JK_RS06660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS06665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS06670	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JK_RS06680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JK_RS06685	COG0440	acetolactate synthase activity
JK_RS06690	COG0028	Belongs to the TPP enzyme family
JK_RS06695	COG0668	transmembrane transport
JK_RS06705	COG0129	dihydroxy-acid dehydratase activity
JK_RS06720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JK_RS06730	COG0205	6-phosphofructokinase activity
JK_RS06745	COG0154	amidase activity
JK_RS06750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JK_RS06760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JK_RS06765	COG1301	dicarboxylic acid transport
JK_RS06775	COG2304	oxidoreductase activity
JK_RS06780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JK_RS06795	COG0482	sulfurtransferase activity
JK_RS06815	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JK_RS06835	COG1119	ATPase activity
JK_RS06840	COG0366	Alpha amylase catalytic
JK_RS06845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JK_RS06855	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
JK_RS06865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JK_RS06870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JK_RS06875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JK_RS06880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JK_RS06885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JK_RS06890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JK_RS06895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JK_RS06900	COG0356	it plays a direct role in the translocation of protons across the membrane
JK_RS06910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JK_RS06925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JK_RS06935	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS06945	COG0083	homoserine kinase activity
JK_RS06950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JK_RS06955	COG0460	homoserine dehydrogenase
JK_RS06960	COG0019	diaminopimelate decarboxylase activity
JK_RS06965	COG0018	arginyl-trna synthetase
JK_RS06975	COG2826	transposase and inactivated derivatives, IS30 family
JK_RS06980	COG2801	Transposase and inactivated derivatives
JK_RS06980	COG3415	Transposase
JK_RS07000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JK_RS07010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JK_RS07015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JK_RS07050	COG2272	Belongs to the type-B carboxylesterase lipase family
JK_RS07060	COG1132	(ABC) transporter
JK_RS07065	COG0567	Dehydrogenase, E1 component
JK_RS07065	COG0508	dehydrogenase complex catalyzes the overall conversion of
JK_RS07075	COG2239	Acts as a magnesium transporter
JK_RS07090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JK_RS07095	COG5662	AntiSigma factor
JK_RS07100	COG1595	DNA-templated transcription, initiation
JK_RS07115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JK_RS07120	COG0297	glycogen (starch) synthase activity
JK_RS07125	COG1621	beta-fructofuranosidase activity
JK_RS07145	COG1611	Belongs to the LOG family
JK_RS07150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JK_RS07155	COG1113	amino acid transport
JK_RS07165	COG0564	pseudouridine synthase activity
JK_RS07185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JK_RS07195	COG1217	gtp-binding protein TYPA
JK_RS07225	COG2801	Transposase and inactivated derivatives
JK_RS07225	COG3415	Transposase
JK_RS07260	COG2354	Protein conserved in bacteria
JK_RS07275	COG2814	Major facilitator Superfamily
JK_RS07290	COG0789	Transcriptional regulator
JK_RS07340	COG2217	Heavy metal translocating P-type atpase
JK_RS07350	COG2205	protein histidine kinase activity
JK_RS07355	COG0745	RESPONSE REGULATOR receiver
JK_RS07365	COG2132	Multicopper oxidase
JK_RS07390	COG0789	Transcriptional regulator
JK_RS07410	COG0012	GTP binding
JK_RS07415	COG0733	neurotransmitter:sodium symporter activity
JK_RS07440	COG1570	exodeoxyribonuclease VII activity
JK_RS07445	COG1722	exodeoxyribonuclease VII activity
JK_RS07455	COG1494	fructose-1,6-bisphosphatase
JK_RS07460	COG0114	fumarate hydratase activity
JK_RS07480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JK_RS07510	COG1335	isochorismatase
JK_RS07515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JK_RS07520	COG1072	(Pantothenic acid kinase))
JK_RS07525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JK_RS07535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JK_RS07545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JK_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
JK_RS07560	COG2072	flavoprotein involved in K transport
JK_RS07570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JK_RS07570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JK_RS07575	COG2755	lipolytic protein G-D-S-L family
JK_RS07575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JK_RS07610	COG0148	phosphopyruvate hydratase activity
JK_RS07630	COG1121	(ABC) transporter
JK_RS07635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JK_RS07640	COG3956	TIGRFAM MazG family protein
JK_RS07660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JK_RS07665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JK_RS07670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JK_RS07675	COG0193	aminoacyl-tRNA hydrolase activity
JK_RS07680	COG0193	aminoacyl-tRNA hydrolase activity
JK_RS07690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JK_RS07695	COG2409	Drug exporters of the RND superfamily
JK_RS07715	COG1024	Enoyl-CoA hydratase
JK_RS07720	COG2326	polyphosphate kinase activity
JK_RS07725	COG5650	phosphatidylinositol metabolic process
JK_RS07745	COG0488	(ABC) transporter
JK_RS07750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JK_RS07755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JK_RS07760	COG3583	domain protein
JK_RS07765	COG0084	hydrolase, TatD family'
JK_RS07770	COG2807	transmembrane transport
JK_RS07780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JK_RS07785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JK_RS07795	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
JK_RS07840	COG0315	cyclic pyranopterin monophosphate synthase activity
JK_RS07840	COG0521	Mo-molybdopterin cofactor biosynthetic process
JK_RS07845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JK_RS07850	COG2205	protein histidine kinase activity
JK_RS07865	COG0254	rRNA binding
JK_RS07870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JK_RS07875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JK_RS07880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JK_RS07885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JK_RS07910	COG0183	Belongs to the thiolase family
JK_RS07925	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS07940	COG1960	acyl-CoA dehydrogenase activity
JK_RS07950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JK_RS07990	COG2963	transposase activity
JK_RS07995	COG2801	Transposase and inactivated derivatives
JK_RS08005	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS08015	COG1605	Chorismate mutase
JK_RS08030	COG0778	Nitroreductase
JK_RS08035	COG1704	LemA family
JK_RS08040	COG0501	Belongs to the peptidase M48B family
JK_RS08050	COG3878	Protein conserved in bacteria
JK_RS08070	COG0659	secondary active sulfate transmembrane transporter activity
JK_RS08080	COG3328	transposase activity
JK_RS08105	COG2826	transposase and inactivated derivatives, IS30 family
JK_RS08115	COG3547	Transposase (IS116 IS110 IS902 family)
JK_RS08130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JK_RS08150	COG0315	cyclic pyranopterin monophosphate synthase activity
JK_RS08150	COG0521	Mo-molybdopterin cofactor biosynthetic process
JK_RS08155	COG0315	cyclic pyranopterin monophosphate synthase activity
JK_RS08165	COG0314	molybdopterin synthase activity
JK_RS08170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JK_RS08190	COG1615	UPF0182 protein
JK_RS08200	COG3480	Lon protease (S16) C-terminal proteolytic domain
JK_RS08235	COG0210	DNA helicase
JK_RS08255	COG0513	Belongs to the DEAD box helicase family
JK_RS08295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JK_RS08300	COG1162	GTPase activity
JK_RS08320	COG0653	protein targeting
JK_RS08325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JK_RS08335	COG5401	PFAM Sporulation and spore germination
JK_RS08340	COG5002	protein histidine kinase activity
JK_RS08345	COG0745	RESPONSE REGULATOR receiver
JK_RS08355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JK_RS08370	COG1482	cell wall glycoprotein biosynthetic process
JK_RS08375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JK_RS08395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JK_RS08405	COG1091	dTDP-4-dehydrorhamnose reductase activity
JK_RS08410	COG1316	TRANSCRIPTIONal
JK_RS08425	COG1131	(ABC) transporter
JK_RS08435	COG1131	(ABC) transporter
JK_RS08445	COG2197	response regulator
JK_RS08450	COG4585	Histidine kinase
JK_RS08495	COG0424	maF-like protein
JK_RS08500	COG0372	Belongs to the citrate synthase family
JK_RS08505	COG2079	MmgE PrpD family protein
JK_RS08510	COG0189	ligase activity
JK_RS08515	COG2897	thiosulfate sulfurtransferase activity
JK_RS08520	COG4770	biotin carboxylase activity
JK_RS08530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JK_RS08540	COG1473	amidohydrolase
JK_RS08540	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JK_RS08550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JK_RS08555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JK_RS08610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JK_RS08615	COG1295	ribonuclease BN
JK_RS08620	COG0180	Tryptophanyl-tRNA synthetase
JK_RS08625	COG2860	membrane
JK_RS08635	COG2814	Major facilitator Superfamily
JK_RS08640	COG2838	Isocitrate dehydrogenase
JK_RS08645	COG2873	o-acetylhomoserine
JK_RS08650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JK_RS08660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JK_RS08690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JK_RS08695	COG3268	Saccharopine dehydrogenase
JK_RS08720	COG0587	DNA-directed DNA polymerase activity
JK_RS08725	COG1464	Belongs to the NlpA lipoprotein family
JK_RS08730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JK_RS08735	COG2011	ABC-type metal ion transport system permease component
JK_RS08745	COG2801	Transposase and inactivated derivatives
JK_RS08775	COG0519	Catalyzes the synthesis of GMP from XMP
JK_RS08775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JK_RS08785	COG0516	GMP reductase activity
JK_RS08815	COG0459	protein refolding
JK_RS08820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JK_RS08850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JK_RS08885	COG0697	spore germination
JK_RS08895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JK_RS08930	COG1674	ftsk spoiiie
JK_RS08945	COG0101	tRNA pseudouridine synthase activity
JK_RS08955	COG0203	ribosomal protein L17
JK_RS08960	COG0202	RNA polymerase activity
JK_RS08965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JK_RS08970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JK_RS08975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JK_RS08985	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JK_RS08995	COG0563	adenylate kinase activity
JK_RS09000	COG0201	protein transport
JK_RS09030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS09035	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS09040	COG1120	ATPase activity
JK_RS09070	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JK_RS09080	COG1132	(ABC) transporter
JK_RS09095	COG3328	transposase activity
JK_RS09130	COG0200	Binds to the 23S rRNA
JK_RS09135	COG1841	ribosomal large subunit assembly
JK_RS09140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JK_RS09145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JK_RS09150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JK_RS09155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JK_RS09165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JK_RS09170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JK_RS09175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JK_RS09185	COG2801	Transposase and inactivated derivatives
JK_RS09200	COG1120	ATPase activity
JK_RS09205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS09210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS09225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JK_RS09225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JK_RS09235	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JK_RS09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JK_RS09245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JK_RS09250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS09255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS09260	COG1120	ATPase activity
JK_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
JK_RS09270	COG1021	2,3-dihydroxybenzoate-AMP ligase
JK_RS09285	COG2801	Transposase and inactivated derivatives
JK_RS09290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JK_RS09295	COG0255	Belongs to the universal ribosomal protein uL29 family
JK_RS09300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JK_RS09305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JK_RS09310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JK_RS09315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JK_RS09320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JK_RS09325	COG0089	rRNA binding
JK_RS09330	COG0088	Forms part of the polypeptide exit tunnel
JK_RS09335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JK_RS09340	COG0051	transcription antitermination factor activity, RNA binding
JK_RS09360	COG2188	Transcriptional regulator
JK_RS09365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JK_RS09370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JK_RS09375	COG0049	tRNA binding
JK_RS09380	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JK_RS09390	COG1643	Atp-dependent helicase
JK_RS09400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JK_RS09405	COG0085	RNA polymerase activity
JK_RS09415	COG0222	ribosome binding
JK_RS09420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JK_RS09435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JK_RS09440	COG1121	(ABC) transporter
JK_RS09470	COG0081	regulation of translation
JK_RS09475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JK_RS09480	COG0250	Participates in transcription elongation, termination and antitermination
JK_RS09510	COG0142	geranyltranstransferase activity
JK_RS09515	COG0644	oxidoreductase
JK_RS09520	COG2226	methyltransferase
JK_RS09525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JK_RS09525	COG0438	transferase activity, transferring glycosyl groups
JK_RS09535	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JK_RS09540	COG4948	Mandelate Racemase Muconate Lactonizing
JK_RS09545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JK_RS09560	COG1131	(ABC) transporter
JK_RS09645	COG1088	dTDP-glucose 4,6-dehydratase activity
JK_RS09655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JK_RS09665	COG0785	Cytochrome C biogenesis protein
JK_RS09675	COG0406	alpha-ribazole phosphatase activity
JK_RS09680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JK_RS09705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JK_RS09705	COG1648	precorrin-2 dehydrogenase activity
JK_RS09715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JK_RS09735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JK_RS09755	COG0745	RESPONSE REGULATOR receiver
JK_RS09760	COG5002	protein histidine kinase activity
JK_RS09765	COG0588	phosphoglycerate mutase activity
JK_RS09775	COG0438	transferase activity, transferring glycosyl groups
JK_RS09780	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS09785	COG3239	Fatty acid desaturase
JK_RS09800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JK_RS09820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JK_RS09830	COG2733	membrane
JK_RS09840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JK_RS09845	COG1053	succinate dehydrogenase
JK_RS09860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JK_RS09865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JK_RS09870	COG2224	Isocitrate lyase
JK_RS09875	COG3800	Transcriptional regulator
JK_RS09875	COG1396	sequence-specific DNA binding
JK_RS09885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JK_RS09905	COG2271	Major facilitator Superfamily
JK_RS09915	COG1113	amino acid transport
JK_RS09925	COG3328	transposase activity
JK_RS09930	COG2409	Drug exporters of the RND superfamily
JK_RS09935	COG0204	Acyl-transferase
JK_RS09960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JK_RS09970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JK_RS09975	COG1754	DNA topoisomerase type I activity
JK_RS09975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JK_RS09980	COG1278	Cold shock
JK_RS09985	COG1111	helicase
JK_RS09985	COG1205	dead DEAH box helicase
JK_RS10040	COG0596	Alpha beta hydrolase
JK_RS10065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JK_RS10085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JK_RS10090	COG1408	metallophosphoesterase
JK_RS10105	COG0019	diaminopimelate decarboxylase activity
JK_RS10110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JK_RS10115	COG0534	Mate efflux family protein
JK_RS10125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JK_RS10130	COG1120	ATPase activity
JK_RS10135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JK_RS10135	COG2111	Na H antiporter
JK_RS10140	COG1006	Multisubunit Na H antiporter MnhC subunit
JK_RS10145	COG0651	ATP synthesis coupled electron transport
JK_RS10170	COG1764	response to oxidative stress
JK_RS10185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JK_RS10190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JK_RS10195	COG0527	aspartate kinase activity
JK_RS10200	COG0697	spore germination
JK_RS10215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JK_RS10225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JK_RS10230	COG0798	PFAM Bile acid sodium symporter
JK_RS10240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JK_RS10245	COG3442	glutamine amidotransferase
JK_RS10255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JK_RS10260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JK_RS10275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JK_RS10280	COG0598	Magnesium transport protein CorA
JK_RS10295	COG1024	Enoyl-CoA hydratase
JK_RS10310	COG0343	queuine tRNA-ribosyltransferase activity
JK_RS10315	COG2409	Drug exporters of the RND superfamily
JK_RS10325	COG0590	tRNA wobble adenosine to inosine editing
JK_RS10325	COG0037	tRNA processing
JK_RS10340	COG0287	Prephenate dehydrogenase
JK_RS10380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JK_RS10400	COG0604	alcohol dehydrogenase
JK_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
JK_RS10400	COG3321	synthase
JK_RS10405	COG0697	spore germination
JK_RS10435	COG3328	transposase activity
JK_RS10445	COG0318	PFAM AMP-dependent synthetase and ligase
JK_RS10450	COG1216	Glycosyl transferase, family 2
JK_RS10480	COG0277	FAD linked oxidase domain protein
JK_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
JK_RS10490	COG2814	Major facilitator Superfamily
JK_RS10495	COG1842	Phage shock protein A
JK_RS10510	COG1064	alcohol dehydrogenase
JK_RS10515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JK_RS10535	COG2353	YceI-like domain
JK_RS10545	COG0305	Participates in initiation and elongation during chromosome replication
JK_RS10550	COG2072	flavoprotein involved in K transport
JK_RS10555	COG0359	binds to the 23S rRNA
JK_RS10565	COG0360	Binds together with S18 to 16S ribosomal RNA
JK_RS10580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JK_RS10590	COG1260	myo-inositol-1-phosphate synthase
JK_RS10610	COG0495	leucyl-tRNA aminoacylation
JK_RS10625	COG1957	nucleoside hydrolase
JK_RS10645	COG0477	Major facilitator Superfamily
JK_RS10660	COG1687	branched-chain amino acid
JK_RS10665	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JK_RS10675	COG0617	tRNA 3'-terminal CCA addition
JK_RS10710	COG3409	Peptidoglycan-binding domain 1 protein
JK_RS10710	COG0860	N-Acetylmuramoyl-L-alanine amidase
JK_RS10720	COG0778	Nitroreductase
JK_RS10730	COG1192	Involved in chromosome partitioning
JK_RS10735	COG0357	Ribosomal RNA small subunit methyltransferase G
JK_RS10740	COG0706	membrane insertase activity
JK_RS10745	COG0594	ribonuclease P activity
JK_RS10750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JK_RS10815	COG1192	Involved in chromosome partitioning
JK_RS10830	COG0657	acetylesterase activity