locus-tag	class	description
I6H49_RS00010	COG2826	transposase and inactivated derivatives, IS30 family
I6H49_RS00025	COG0577	efflux transmembrane transporter activity
I6H49_RS00025	COG1136	(ABC) transporter
I6H49_RS00040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6H49_RS00045	COG2027	D-alanyl-D-alanine carboxypeptidase
I6H49_RS00050	COG0037	tRNA processing
I6H49_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H49_RS00065	COG0302	gtp cyclohydrolase
I6H49_RS00080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H49_RS00100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H49_RS00115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H49_RS00130	COG0477	Major facilitator Superfamily
I6H49_RS00140	COG0515	serine threonine protein kinase
I6H49_RS00140	COG2815	serine threonine protein kinase
I6H49_RS00155	COG0542	response to heat
I6H49_RS00180	COG1194	a g-specific adenine glycosylase
I6H49_RS00195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H49_RS00210	COG2847	Copper chaperone PCu(A)C
I6H49_RS00245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H49_RS00275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H49_RS00280	COG3842	ATPase activity
I6H49_RS00290	COG1609	Transcriptional regulator
I6H49_RS00295	COG1877	trehalose-phosphatase activity
I6H49_RS00305	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6H49_RS00330	COG0477	Major facilitator Superfamily
I6H49_RS00335	COG0028	Belongs to the TPP enzyme family
I6H49_RS00345	COG0745	RESPONSE REGULATOR receiver
I6H49_RS00350	COG2205	protein histidine kinase activity
I6H49_RS00365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H49_RS00415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H49_RS00420	COG0047	phosphoribosylformylglycinamidine synthase activity
I6H49_RS00425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H49_RS00430	COG1272	protein, Hemolysin III
I6H49_RS00445	COG0183	Belongs to the thiolase family
I6H49_RS00450	COG1028	Short-chain dehydrogenase reductase Sdr
I6H49_RS00455	COG2030	dehydratase
I6H49_RS00475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H49_RS00500	COG1597	lipid kinase activity
I6H49_RS00510	COG0456	acetyltransferase
I6H49_RS00530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H49_RS00555	COG1937	Protein conserved in bacteria
I6H49_RS00585	COG1045	serine acetyltransferase
I6H49_RS00590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H49_RS00595	COG2197	response regulator
I6H49_RS00635	COG2239	Acts as a magnesium transporter
I6H49_RS00650	COG0577	efflux transmembrane transporter activity
I6H49_RS00650	COG1136	(ABC) transporter
I6H49_RS00655	COG1136	(ABC) transporter
I6H49_RS00655	COG0577	efflux transmembrane transporter activity
I6H49_RS00660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H49_RS00670	COG0033	Phosphoglucomutase
I6H49_RS00705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H49_RS00710	COG2814	Major facilitator Superfamily
I6H49_RS00715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H49_RS00735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H49_RS00750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H49_RS00770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H49_RS00780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6H49_RS00790	COG3191	aminopeptidase activity
I6H49_RS00805	COG1234	tRNA 3'-trailer cleavage
I6H49_RS00810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6H49_RS00845	COG1882	Formate acetyltransferase
I6H49_RS00850	COG1882	Formate acetyltransferase
I6H49_RS00855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H49_RS00900	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H49_RS00910	COG2826	transposase and inactivated derivatives, IS30 family
I6H49_RS00930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H49_RS00935	COG4139	cobalamin transport
I6H49_RS00955	COG1376	ErfK ybiS ycfS ynhG family protein
I6H49_RS00965	COG2094	Belongs to the DNA glycosylase MPG family
I6H49_RS00980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6H49_RS00985	COG1115	amino acid carrier protein
I6H49_RS00990	COG4221	oxidoreductase activity
I6H49_RS00995	COG1983	PspC domain protein
I6H49_RS01010	COG0583	DNA-binding transcription factor activity
I6H49_RS01045	COG0686	Belongs to the AlaDH PNT family
I6H49_RS01055	COG0668	transmembrane transport
I6H49_RS01070	COG0747	negative chemotaxis
I6H49_RS01080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H49_RS01095	COG0300	oxidoreductase activity
I6H49_RS01100	COG2188	Transcriptional regulator
I6H49_RS01115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6H49_RS01150	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H49_RS01155	COG0431	NADPH-dependent FMN reductase
I6H49_RS01165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H49_RS01170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H49_RS01175	COG1780	Probably involved in ribonucleotide reductase function
I6H49_RS01190	COG0740	serine-type endopeptidase activity
I6H49_RS01200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H49_RS01205	COG2390	Transcriptional regulator
I6H49_RS01210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6H49_RS01215	COG0295	cytidine deaminase activity
I6H49_RS01225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6H49_RS01230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H49_RS01245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H49_RS01250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6H49_RS01260	COG0285	dihydrofolate synthase activity
I6H49_RS01270	COG0657	acetylesterase activity
I6H49_RS01280	COG0105	UTP biosynthetic process
I6H49_RS01285	COG0640	Transcriptional regulator
I6H49_RS01290	COG0798	PFAM Bile acid sodium symporter
I6H49_RS01300	COG1530	ribonuclease E activity
I6H49_RS01305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H49_RS01310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H49_RS01330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H49_RS01360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H49_RS01375	COG1307	EDD domain protein, DegV family
I6H49_RS01415	COG0268	Binds directly to 16S ribosomal RNA
I6H49_RS01425	COG0481	GTPase activity
I6H49_RS01445	COG1473	amidohydrolase
I6H49_RS01465	COG4585	Histidine kinase
I6H49_RS01470	COG2197	response regulator
I6H49_RS01510	COG2186	Transcriptional regulator
I6H49_RS01515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H49_RS01520	COG1114	Component of the transport system for branched-chain amino acids
I6H49_RS01530	COG1132	(ABC) transporter
I6H49_RS01540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6H49_RS01560	COG1022	Amp-dependent synthetase and ligase
I6H49_RS01570	COG1253	flavin adenine dinucleotide binding
I6H49_RS01575	COG1253	flavin adenine dinucleotide binding
I6H49_RS01585	COG1420	regulation of RNA biosynthetic process
I6H49_RS01605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H49_RS01620	COG1381	Involved in DNA repair and RecF pathway recombination
I6H49_RS01625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H49_RS01650	COG0423	glycine-tRNA ligase activity
I6H49_RS01705	COG0671	phosphoesterase, PA-phosphatase related
I6H49_RS01710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6H49_RS01745	COG2801	Transposase and inactivated derivatives
I6H49_RS01750	COG2801	Transposase and inactivated derivatives
I6H49_RS01760	COG0659	secondary active sulfate transmembrane transporter activity
I6H49_RS01765	COG0789	Transcriptional regulator
I6H49_RS01800	COG0789	Transcriptional regulator
I6H49_RS01815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H49_RS01820	COG4988	ABC transporter
I6H49_RS01825	COG1294	oxidase, subunit
I6H49_RS01830	COG1271	oxidase subunit
I6H49_RS01840	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H49_RS01865	COG0640	Transcriptional regulator
I6H49_RS01900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6H49_RS01925	COG1134	teichoic acid transport
I6H49_RS01945	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H49_RS01960	COG0833	amino acid
I6H49_RS01995	COG3547	Transposase (IS116 IS110 IS902 family)
I6H49_RS02015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H49_RS02035	COG1764	response to oxidative stress
I6H49_RS02055	COG2860	membrane
I6H49_RS02060	COG4166	transmembrane transport
I6H49_RS02065	COG0668	transmembrane transport
I6H49_RS02095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H49_RS02100	COG2267	carboxylic ester hydrolase activity
I6H49_RS02105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6H49_RS02130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H49_RS02175	COG0174	glutamine synthetase
I6H49_RS02180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6H49_RS02195	COG2271	Major facilitator Superfamily
I6H49_RS02200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H49_RS02220	COG4335	DNA alkylation repair
I6H49_RS02245	COG0174	glutamine synthetase
I6H49_RS02260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H49_RS02265	COG0321	lipoyl(octanoyl) transferase activity
I6H49_RS02270	COG0509	glycine decarboxylation via glycine cleavage system
I6H49_RS02275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6H49_RS02280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H49_RS02280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H49_RS02290	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H49_RS02300	COG1335	isochorismatase
I6H49_RS02305	COG2066	Belongs to the glutaminase family
I6H49_RS02315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H49_RS02320	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6H49_RS02370	COG0791	NLP P60 protein
I6H49_RS02380	COG0438	transferase activity, transferring glycosyl groups
I6H49_RS02385	COG1940	carbohydrate kinase activity
I6H49_RS02405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6H49_RS02425	COG0142	geranyltranstransferase activity
I6H49_RS02450	COG0275	rRNA processing
I6H49_RS02460	COG0768	penicillin binding
I6H49_RS02465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H49_RS02475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H49_RS02490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H49_RS02495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H49_RS02505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H49_RS02510	COG1496	oxidoreductase activity
I6H49_RS02515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H49_RS02520	COG1799	cell septum assembly
I6H49_RS02530	COG3599	regulation of cell shape
I6H49_RS02545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H49_RS02585	COG0252	asparaginase activity
I6H49_RS02630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H49_RS02645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H49_RS02650	COG1739	Uncharacterized protein family UPF0029
I6H49_RS02705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H49_RS02710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H49_RS02715	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H49_RS02730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6H49_RS02740	COG0483	inositol monophosphate 1-phosphatase activity
I6H49_RS02745	COG0107	imidazoleglycerol-phosphate synthase activity
I6H49_RS02770	COG0469	pyruvate kinase activity
I6H49_RS02775	COG0058	SHG alpha-glucan phosphorylase activity
I6H49_RS02790	COG1929	Belongs to the glycerate kinase type-1 family
I6H49_RS02795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H49_RS02815	COG0571	ribonuclease III activity
I6H49_RS02820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H49_RS02825	COG1115	amino acid carrier protein
I6H49_RS02830	COG1254	Belongs to the acylphosphatase family
I6H49_RS02835	COG1196	nuclear chromosome segregation
I6H49_RS02845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H49_RS02845	COG2111	Na H antiporter
I6H49_RS02850	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H49_RS02855	COG0651	ATP synthesis coupled electron transport
I6H49_RS02880	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6H49_RS02895	COG0228	four-way junction DNA binding
I6H49_RS02910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H49_RS02915	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H49_RS02940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H49_RS02945	COG2022	thiamine diphosphate biosynthetic process
I6H49_RS02960	COG0352	thiamine-phosphate diphosphorylase activity
I6H49_RS02975	COG0681	Belongs to the peptidase S26 family
I6H49_RS02980	COG0681	Belongs to the peptidase S26 family
I6H49_RS02985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H49_RS02995	COG0792	nuclease activity
I6H49_RS03010	COG4974	Belongs to the 'phage' integrase family
I6H49_RS03025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H49_RS03030	COG0528	UMP kinase activity
I6H49_RS03035	COG0233	cytoplasmic translational termination
I6H49_RS03040	COG0575	Belongs to the CDS family
I6H49_RS03050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H49_RS03070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6H49_RS03080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H49_RS03085	COG0768	penicillin binding
I6H49_RS03115	COG0579	oxidoreductase
I6H49_RS03120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6H49_RS03140	COG3022	response to hydroperoxide
I6H49_RS03145	COG0442	prolyl-tRNA aminoacylation
I6H49_RS03160	COG0779	Required for maturation of 30S ribosomal subunits
I6H49_RS03175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H49_RS03180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H49_RS03185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H49_RS03190	COG0534	Mate efflux family protein
I6H49_RS03195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H49_RS03200	COG2977	Belongs to the P-Pant transferase superfamily
I6H49_RS03205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H49_RS03220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H49_RS03225	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H49_RS03235	COG1403	HNH endonuclease
I6H49_RS03240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H49_RS03245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6H49_RS03250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H49_RS03255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6H49_RS03265	COG1674	ftsk spoiiie
I6H49_RS03290	COG1396	sequence-specific DNA binding
I6H49_RS03295	COG1842	Phage shock protein A
I6H49_RS03300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H49_RS03305	COG1122	ATPase activity
I6H49_RS03310	COG1268	BioY protein
I6H49_RS03320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H49_RS03325	COG2137	regulation of response to DNA damage stimulus
I6H49_RS03330	COG0765	amino acid transport
I6H49_RS03335	COG0765	amino acid transport
I6H49_RS03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H49_RS03345	COG1126	abc transporter atp-binding protein
I6H49_RS03370	COG1196	nuclear chromosome segregation
I6H49_RS03385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H49_RS03400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H49_RS03405	COG2233	PERMEase
I6H49_RS03420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H49_RS03425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H49_RS03425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H49_RS03425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H49_RS03430	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H49_RS03435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H49_RS03440	COG1349	DNA-binding transcription factor activity
I6H49_RS03445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H49_RS03450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H49_RS03455	COG1643	Atp-dependent helicase
I6H49_RS03465	COG0583	DNA-binding transcription factor activity
I6H49_RS03470	COG0450	alkyl hydroperoxide reductase
I6H49_RS03475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H49_RS03505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H49_RS03510	COG1321	iron dependent repressor
I6H49_RS03525	COG1760	l-serine dehydratase
I6H49_RS03530	COG0814	amino acid
I6H49_RS03540	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H49_RS03555	COG1061	Type III restriction enzyme res subunit
I6H49_RS03575	COG0156	8-amino-7-oxononanoate synthase activity
I6H49_RS03605	COG4208	sulfate ABC transporter
I6H49_RS03610	COG3842	ATPase activity
I6H49_RS03615	COG1234	tRNA 3'-trailer cleavage
I6H49_RS03685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H49_RS03690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6H49_RS03695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6H49_RS03705	COG3253	May function as heme-dependent peroxidase
I6H49_RS03795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H49_RS03805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H49_RS03810	COG1560	Kdo2-lipid A biosynthetic process
I6H49_RS03815	COG0438	transferase activity, transferring glycosyl groups
I6H49_RS03835	COG1946	Acyl-CoA thioesterase
I6H49_RS03840	COG0217	transcriptional regulatory protein
I6H49_RS03845	COG0778	Nitroreductase
I6H49_RS03850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H49_RS03855	COG0632	four-way junction helicase activity
I6H49_RS03860	COG2255	four-way junction helicase activity
I6H49_RS03870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H49_RS03875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H49_RS03880	COG0747	negative chemotaxis
I6H49_RS03890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H49_RS03895	COG0737	Belongs to the 5'-nucleotidase family
I6H49_RS03900	COG2323	membrane
I6H49_RS03925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H49_RS03930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H49_RS03935	COG0124	histidyl-tRNA synthetase
I6H49_RS03940	COG1760	l-serine dehydratase
I6H49_RS03945	COG0431	NADPH-dependent FMN reductase
I6H49_RS03950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H49_RS03970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H49_RS03990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H49_RS04000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H49_RS04015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H49_RS04020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H49_RS04025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H49_RS04030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H49_RS04035	COG0006	proline dipeptidase activity
I6H49_RS04040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H49_RS04045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H49_RS04055	COG0765	amino acid transport
I6H49_RS04060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H49_RS04090	COG2226	methyltransferase
I6H49_RS04095	COG0539	negative regulation of cytoplasmic translation
I6H49_RS04100	COG0237	dephospho-CoA kinase activity
I6H49_RS04135	COG3973	AAA domain
I6H49_RS04165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H49_RS04170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H49_RS04180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H49_RS04190	COG0072	phenylalanine-tRNA ligase activity
I6H49_RS04190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H49_RS04200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6H49_RS04205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6H49_RS04215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H49_RS04220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H49_RS04225	COG1438	arginine binding
I6H49_RS04230	COG0137	argininosuccinate synthase activity
I6H49_RS04235	COG0165	Argininosuccinate lyase
I6H49_RS04245	COG2304	oxidoreductase activity
I6H49_RS04255	COG2835	tetraacyldisaccharide 4'-kinase activity
I6H49_RS04310	COG0647	UMP catabolic process
I6H49_RS04325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H49_RS04345	COG0494	nUDIX hydrolase
I6H49_RS04350	COG4974	Belongs to the 'phage' integrase family
I6H49_RS04370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H49_RS04380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H49_RS04385	COG1160	GTP binding
I6H49_RS04390	COG2197	response regulator
I6H49_RS04395	COG4585	Histidine kinase
I6H49_RS04405	COG1131	(ABC) transporter
I6H49_RS04445	COG1136	(ABC) transporter
I6H49_RS04455	COG3012	SEC-C Motif Domain Protein
I6H49_RS04465	COG0653	protein targeting
I6H49_RS04470	COG1716	ATPase activity
I6H49_RS04500	COG0513	Belongs to the DEAD box helicase family
I6H49_RS04515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H49_RS04525	COG0598	Magnesium transport protein CorA
I6H49_RS04535	COG0352	thiamine-phosphate diphosphorylase activity
I6H49_RS04535	COG0351	phosphomethylpyrimidine kinase
I6H49_RS04535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H49_RS04540	COG1252	NADH dehydrogenase
I6H49_RS04550	COG0584	glycerophosphoryl diester phosphodiesterase
I6H49_RS04555	COG1175	transmembrane transport
I6H49_RS04570	COG3842	ATPase activity
I6H49_RS04630	COG3842	ATPase activity
I6H49_RS04635	COG0463	Glycosyl transferase, family 2
I6H49_RS04655	COG0300	oxidoreductase activity
I6H49_RS04675	COG0805	protein transport
I6H49_RS04680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H49_RS04695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6H49_RS04705	COG4122	O-methyltransferase activity
I6H49_RS04710	COG1222	aaa ATPase
I6H49_RS04720	COG1362	aminopeptidase activity
I6H49_RS04735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H49_RS04740	COG1027	Aspartate ammonia-lyase
I6H49_RS04745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6H49_RS04750	COG0140	phosphoribosyl-ATP diphosphatase activity
I6H49_RS04755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H49_RS04765	COG0215	cysteine-tRNA ligase activity
I6H49_RS04770	COG1968	undecaprenyl-diphosphatase activity
I6H49_RS04780	COG0167	dihydroorotate dehydrogenase activity
I6H49_RS04790	COG1881	PFAM PEBP family protein
I6H49_RS04830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H49_RS04835	COG0791	NLP P60 protein
I6H49_RS04835	COG3883	PFAM NLP P60 protein
I6H49_RS04845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H49_RS04880	COG3830	Belongs to the UPF0237 family
I6H49_RS04885	COG2848	UPF0210 protein
I6H49_RS04905	COG0488	(ABC) transporter
I6H49_RS04910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H49_RS04910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H49_RS04910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H49_RS04920	COG0822	iron-sulfur transferase activity
I6H49_RS04930	COG0396	ATPase activity
I6H49_RS04985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H49_RS05005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H49_RS05010	COG0149	triose-phosphate isomerase activity
I6H49_RS05015	COG0126	phosphoglycerate kinase activity
I6H49_RS05020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H49_RS05025	COG1481	regulation of sporulation
I6H49_RS05035	COG1660	Displays ATPase and GTPase activities
I6H49_RS05040	COG0322	excinuclease ABC activity
I6H49_RS05050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H49_RS05080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H49_RS05085	COG0242	peptide deformylase activity
I6H49_RS05095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H49_RS05105	COG1758	RNA polymerase activity
I6H49_RS05110	COG0194	GDP metabolic process
I6H49_RS05125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H49_RS05130	COG0505	Belongs to the CarA family
I6H49_RS05135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H49_RS05140	COG0540	Belongs to the ATCase OTCase family
I6H49_RS05175	COG2326	polyphosphate kinase activity
I6H49_RS05185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H49_RS05190	COG0742	ribosomal rna small subunit methyltransferase
I6H49_RS05195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H49_RS05200	COG1461	Dihydroxyacetone kinase
I6H49_RS05205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H49_RS05210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6H49_RS05220	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H49_RS05225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H49_RS05230	COG0406	alpha-ribazole phosphatase activity
I6H49_RS05230	COG0494	nUDIX hydrolase
I6H49_RS05245	COG0066	3-isopropylmalate dehydratase activity
I6H49_RS05250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H49_RS05320	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H49_RS05330	COG1121	(ABC) transporter
I6H49_RS05335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H49_RS05350	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H49_RS05365	COG0473	3-isopropylmalate dehydrogenase activity
I6H49_RS05385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H49_RS05395	COG0028	Belongs to the TPP enzyme family
I6H49_RS05405	COG0129	dihydroxy-acid dehydratase activity
I6H49_RS05410	COG5650	phosphatidylinositol metabolic process
I6H49_RS05430	COG0583	DNA-binding transcription factor activity
I6H49_RS05440	COG3949	Membrane
I6H49_RS05445	COG1064	alcohol dehydrogenase
I6H49_RS05460	COG0205	6-phosphofructokinase activity
I6H49_RS05485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H49_RS05505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H49_RS05520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H49_RS05570	COG0482	sulfurtransferase activity
I6H49_RS05610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6H49_RS05630	COG1119	ATPase activity
I6H49_RS05635	COG0366	Alpha amylase catalytic
I6H49_RS05645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H49_RS05650	COG0747	negative chemotaxis
I6H49_RS05675	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6H49_RS05685	COG2826	transposase and inactivated derivatives, IS30 family
I6H49_RS05690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H49_RS05695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H49_RS05700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H49_RS05705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H49_RS05710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H49_RS05715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H49_RS05720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H49_RS05725	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H49_RS05735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H49_RS05750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H49_RS05760	COG0318	PFAM AMP-dependent synthetase and ligase
I6H49_RS05775	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H49_RS05780	COG0746	molybdenum cofactor guanylyltransferase activity
I6H49_RS05815	COG0083	homoserine kinase activity
I6H49_RS05820	COG0460	homoserine dehydrogenase
I6H49_RS05825	COG0019	diaminopimelate decarboxylase activity
I6H49_RS05830	COG0018	arginyl-trna synthetase
I6H49_RS05835	COG1620	l-lactate permease
I6H49_RS05840	COG0247	lactate metabolic process
I6H49_RS05845	COG1139	Iron-sulfur cluster binding protein
I6H49_RS05850	COG1556	Lactate utilization protein
I6H49_RS05870	COG2826	transposase and inactivated derivatives, IS30 family
I6H49_RS05905	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H49_RS05915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H49_RS05920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H49_RS05945	COG1228	amidohydrolase
I6H49_RS05950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6H49_RS05955	COG2986	histidine ammonia-lyase
I6H49_RS05965	COG3314	Sporulation integral membrane protein YlbJ
I6H49_RS05975	COG0010	Belongs to the arginase family
I6H49_RS06020	COG2272	Belongs to the type-B carboxylesterase lipase family
I6H49_RS06030	COG0567	Dehydrogenase, E1 component
I6H49_RS06030	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H49_RS06040	COG2826	transposase and inactivated derivatives, IS30 family
I6H49_RS06070	COG1595	DNA-templated transcription, initiation
I6H49_RS06080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H49_RS06085	COG0297	glycogen (starch) synthase activity
I6H49_RS06115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H49_RS06120	COG1611	Belongs to the LOG family
I6H49_RS06125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H49_RS06130	COG1113	amino acid transport
I6H49_RS06140	COG1113	amino acid transport
I6H49_RS06150	COG1476	TRANSCRIPTIONal
I6H49_RS06195	COG1217	gtp-binding protein TYPA
I6H49_RS06210	COG2354	Protein conserved in bacteria
I6H49_RS06215	COG0428	transporter
I6H49_RS06235	COG3549	Plasmid maintenance system killer
I6H49_RS06255	COG0709	Synthesizes selenophosphate from selenide and ATP
I6H49_RS06265	COG0437	4 iron, 4 sulfur cluster binding
I6H49_RS06270	COG3383	formate dehydrogenase (NAD+) activity
I6H49_RS06270	COG0243	molybdopterin cofactor binding
I6H49_RS06275	COG0243	molybdopterin cofactor binding
I6H49_RS06275	COG3383	formate dehydrogenase (NAD+) activity
I6H49_RS06280	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I6H49_RS06285	COG0095	Lipoate-protein ligase
I6H49_RS06290	COG1301	dicarboxylic acid transport
I6H49_RS06295	COG2814	Major facilitator Superfamily
I6H49_RS06310	COG1012	belongs to the aldehyde dehydrogenase family
I6H49_RS06320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H49_RS06335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6H49_RS06340	COG3639	organic phosphonate transmembrane transporter activity
I6H49_RS06345	COG3639	organic phosphonate transmembrane transporter activity
I6H49_RS06355	COG0012	GTP binding
I6H49_RS06365	COG1322	Protein conserved in bacteria
I6H49_RS06380	COG1570	exodeoxyribonuclease VII activity
I6H49_RS06385	COG1722	exodeoxyribonuclease VII activity
I6H49_RS06400	COG1494	fructose-1,6-bisphosphatase
I6H49_RS06405	COG0114	fumarate hydratase activity
I6H49_RS06415	COG0477	Major facilitator Superfamily
I6H49_RS06430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6H49_RS06455	COG1072	(Pantothenic acid kinase))
I6H49_RS06470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6H49_RS06535	COG0148	phosphopyruvate hydratase activity
I6H49_RS06550	COG3956	TIGRFAM MazG family protein
I6H49_RS06555	COG0531	amino acid
I6H49_RS06575	COG2860	membrane
I6H49_RS06580	COG2132	Multicopper oxidase
I6H49_RS06590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H49_RS06595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H49_RS06605	COG0193	aminoacyl-tRNA hydrolase activity
I6H49_RS06610	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H49_RS06620	COG2326	polyphosphate kinase activity
I6H49_RS06625	COG4585	Histidine kinase
I6H49_RS06630	COG2197	response regulator
I6H49_RS06635	COG1131	(ABC) transporter
I6H49_RS06650	COG2070	2-Nitropropane dioxygenase
I6H49_RS06655	COG0193	aminoacyl-tRNA hydrolase activity
I6H49_RS06665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H49_RS06670	COG2985	domain, Protein
I6H49_RS06670	COG0569	domain protein
I6H49_RS06695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H49_RS06715	COG0561	phosphatase activity
I6H49_RS06720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H49_RS06720	COG2755	lipolytic protein G-D-S-L family
I6H49_RS06740	COG0488	(ABC) transporter
I6H49_RS06760	COG3583	domain protein
I6H49_RS06765	COG0084	hydrolase, TatD family'
I6H49_RS06770	COG0456	acetyltransferase
I6H49_RS06785	COG2807	transmembrane transport
I6H49_RS06795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H49_RS06805	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6H49_RS06820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H49_RS06825	COG0519	Catalyzes the synthesis of GMP from XMP
I6H49_RS06845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H49_RS06870	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H49_RS06870	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H49_RS06875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H49_RS06880	COG2205	protein histidine kinase activity
I6H49_RS06885	COG0745	RESPONSE REGULATOR receiver
I6H49_RS06895	COG0254	rRNA binding
I6H49_RS06900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H49_RS06905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H49_RS06910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H49_RS06915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H49_RS06935	COG0515	serine threonine protein kinase
I6H49_RS06960	COG0138	bifunctional purine biosynthesis protein purh
I6H49_RS06975	COG0739	heme binding
I6H49_RS06990	COG1136	(ABC) transporter
I6H49_RS06990	COG0577	efflux transmembrane transporter activity
I6H49_RS07010	COG1605	Chorismate mutase
I6H49_RS07040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H49_RS07050	COG1201	RNA secondary structure unwinding
I6H49_RS07055	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6H49_RS07070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H49_RS07080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H49_RS07095	COG3421	Type III restriction
I6H49_RS07105	COG2826	transposase and inactivated derivatives, IS30 family
I6H49_RS07135	COG1765	OsmC-like protein
I6H49_RS07145	COG3757	hydrolase, family 25
I6H49_RS07155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H49_RS07170	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H49_RS07175	COG0372	Belongs to the citrate synthase family
I6H49_RS07195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H49_RS07200	COG2252	PERMEase
I6H49_RS07225	COG1652	LysM domain
I6H49_RS07240	COG0513	Belongs to the DEAD box helicase family
I6H49_RS07295	COG4607	ABC-type enterochelin transport system periplasmic component
I6H49_RS07305	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6H49_RS07325	COG0814	amino acid
I6H49_RS07340	COG2177	Part of the ABC transporter FtsEX involved in
I6H49_RS07345	COG2884	Cell division ATP-binding protein ftsE
I6H49_RS07350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H49_RS07355	COG0483	inositol monophosphate 1-phosphatase activity
I6H49_RS07360	COG0483	inositol monophosphate 1-phosphatase activity
I6H49_RS07395	COG4762	Protein conserved in bacteria
I6H49_RS07415	COG4974	Belongs to the 'phage' integrase family
I6H49_RS07475	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H49_RS07505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H49_RS07515	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6H49_RS07555	COG5662	AntiSigma factor
I6H49_RS07565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H49_RS07570	COG2135	peptidase activity
I6H49_RS07575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H49_RS07580	COG1162	GTPase activity
I6H49_RS07615	COG0653	protein targeting
I6H49_RS07625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H49_RS07635	COG5401	PFAM Sporulation and spore germination
I6H49_RS07640	COG5002	protein histidine kinase activity
I6H49_RS07645	COG0745	RESPONSE REGULATOR receiver
I6H49_RS07665	COG1482	cell wall glycoprotein biosynthetic process
I6H49_RS07680	COG0730	response to heat
I6H49_RS07695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H49_RS07735	COG1316	TRANSCRIPTIONal
I6H49_RS07755	COG0028	Belongs to the TPP enzyme family
I6H49_RS07760	COG0814	amino acid
I6H49_RS07770	COG1012	belongs to the aldehyde dehydrogenase family
I6H49_RS07825	COG1024	Enoyl-CoA hydratase
I6H49_RS07845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H49_RS07860	COG0477	Major facilitator Superfamily
I6H49_RS07880	COG2610	gluconate transmembrane transporter activity
I6H49_RS07885	COG3265	gluconokinase activity
I6H49_RS07895	COG2040	homocysteine
I6H49_RS07900	COG0517	IMP dehydrogenase activity
I6H49_RS07900	COG4175	Glycine betaine
I6H49_RS07910	COG2113	Glycine betaine
I6H49_RS07915	COG2340	Cysteine-rich secretory protein family
I6H49_RS07930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H49_RS07935	COG2186	Transcriptional regulator
I6H49_RS07950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H49_RS07960	COG1201	RNA secondary structure unwinding
I6H49_RS07970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H49_RS08010	COG2235	arginine
I6H49_RS08095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6H49_RS08100	COG1984	allophanate hydrolase subunit 2
I6H49_RS08105	COG4770	biotin carboxylase activity
I6H49_RS08130	COG0577	efflux transmembrane transporter activity
I6H49_RS08130	COG1136	(ABC) transporter
I6H49_RS08135	COG2801	Transposase and inactivated derivatives
I6H49_RS08140	COG4336	lyase activity
I6H49_RS08145	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H49_RS08150	COG0183	Belongs to the thiolase family
I6H49_RS08155	COG1024	Enoyl-CoA hydratase
I6H49_RS08155	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H49_RS08200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H49_RS08215	COG3527	Alpha-acetolactate decarboxylase
I6H49_RS08230	COG3842	ATPase activity
I6H49_RS08265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H49_RS08270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H49_RS08280	COG0424	maF-like protein
I6H49_RS08295	COG0189	ligase activity
I6H49_RS08300	COG2897	thiosulfate sulfurtransferase activity
I6H49_RS08305	COG4770	biotin carboxylase activity
I6H49_RS08315	COG1373	ATPase (AAA superfamily
I6H49_RS08320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6H49_RS08325	COG1136	(ABC) transporter
I6H49_RS08335	COG0372	Belongs to the citrate synthase family
I6H49_RS08340	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6H49_RS08345	COG2079	MmgE PrpD family protein
I6H49_RS08350	COG1396	sequence-specific DNA binding
I6H49_RS08350	COG3800	Transcriptional regulator
I6H49_RS08365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6H49_RS08365	COG1473	amidohydrolase
I6H49_RS08370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H49_RS08395	COG1686	Belongs to the peptidase S11 family
I6H49_RS08410	COG0180	Tryptophanyl-tRNA synthetase
I6H49_RS08425	COG2814	Major facilitator Superfamily
I6H49_RS08430	COG2838	Isocitrate dehydrogenase
I6H49_RS08440	COG0339	signal peptide processing
I6H49_RS08465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H49_RS08475	COG1595	DNA-templated transcription, initiation
I6H49_RS08515	COG2873	o-acetylhomoserine
I6H49_RS08520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H49_RS08530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H49_RS08535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H49_RS08540	COG0469	pyruvate kinase activity
I6H49_RS08580	COG0587	DNA-directed DNA polymerase activity
I6H49_RS08585	COG1464	Belongs to the NlpA lipoprotein family
I6H49_RS08595	COG2011	ABC-type metal ion transport system permease component
I6H49_RS08610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H49_RS08665	COG0516	GMP reductase activity
I6H49_RS08705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H49_RS08715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H49_RS08720	COG1214	PFAM Peptidase M22, glycoprotease
I6H49_RS08720	COG0456	acetyltransferase
I6H49_RS08735	COG2985	domain, Protein
I6H49_RS08735	COG0569	domain protein
I6H49_RS08745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H49_RS08775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H49_RS08805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H49_RS08830	COG1674	ftsk spoiiie
I6H49_RS08850	COG0101	tRNA pseudouridine synthase activity
I6H49_RS08855	COG2860	membrane
I6H49_RS08860	COG0203	ribosomal protein L17
I6H49_RS08865	COG0202	RNA polymerase activity
I6H49_RS08870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H49_RS08875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H49_RS08880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H49_RS08900	COG0563	adenylate kinase activity
I6H49_RS08905	COG0201	protein transport
I6H49_RS08910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H49_RS08925	COG0200	Binds to the 23S rRNA
I6H49_RS08930	COG1841	ribosomal large subunit assembly
I6H49_RS08935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H49_RS08940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H49_RS08945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H49_RS08960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H49_RS08970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H49_RS08975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H49_RS08980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H49_RS08990	COG1621	beta-fructofuranosidase activity
I6H49_RS08995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H49_RS09005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H49_RS09010	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H49_RS09015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H49_RS09020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H49_RS09025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H49_RS09030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H49_RS09035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H49_RS09040	COG0089	rRNA binding
I6H49_RS09045	COG0088	Forms part of the polypeptide exit tunnel
I6H49_RS09050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H49_RS09055	COG0051	transcription antitermination factor activity, RNA binding
I6H49_RS09060	COG1302	Protein conserved in bacteria
I6H49_RS09100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H49_RS09105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H49_RS09110	COG0049	tRNA binding
I6H49_RS09115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H49_RS09120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H49_RS09130	COG1122	ATPase activity
I6H49_RS09135	COG4721	ABC-type cobalt transport system, permease component
I6H49_RS09150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H49_RS09170	COG3549	Plasmid maintenance system killer
I6H49_RS09175	COG0222	ribosome binding
I6H49_RS09180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H49_RS09185	COG1120	ATPase activity
I6H49_RS09190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H49_RS09195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H49_RS09210	COG0081	regulation of translation
I6H49_RS09215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H49_RS09225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H49_RS09250	COG0142	geranyltranstransferase activity
I6H49_RS09260	COG2226	methyltransferase
I6H49_RS09265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H49_RS09265	COG0438	transferase activity, transferring glycosyl groups
I6H49_RS09290	COG4948	Mandelate Racemase Muconate Lactonizing
I6H49_RS09295	COG3069	C4-dicarboxylate transmembrane transporter activity
I6H49_RS09305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H49_RS09325	COG1321	iron dependent repressor
I6H49_RS09330	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H49_RS09335	COG1121	(ABC) transporter
I6H49_RS09340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H49_RS09340	COG1321	iron dependent repressor
I6H49_RS09345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H49_RS09350	COG1575	Belongs to the MenA family. Type 1 subfamily
I6H49_RS09370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H49_RS09375	COG1333	cytochrome c biogenesis protein
I6H49_RS09380	COG0785	Cytochrome C biogenesis protein
I6H49_RS09390	COG0406	alpha-ribazole phosphatase activity
I6H49_RS09395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H49_RS09410	COG1136	(ABC) transporter
I6H49_RS09415	COG1136	(ABC) transporter
I6H49_RS09415	COG0577	efflux transmembrane transporter activity
I6H49_RS09450	COG1131	(ABC) transporter
I6H49_RS09460	COG0488	(ABC) transporter
I6H49_RS09465	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6H49_RS09470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6H49_RS09485	COG0113	porphobilinogen synthase activity
I6H49_RS09490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H49_RS09490	COG1648	precorrin-2 dehydrogenase activity
I6H49_RS09495	COG0181	hydroxymethylbilane synthase activity
I6H49_RS09500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6H49_RS09535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H49_RS09555	COG0745	RESPONSE REGULATOR receiver
I6H49_RS09560	COG5002	protein histidine kinase activity
I6H49_RS09570	COG0438	transferase activity, transferring glycosyl groups
I6H49_RS09575	COG0318	PFAM AMP-dependent synthetase and ligase
I6H49_RS09580	COG0318	PFAM AMP-dependent synthetase and ligase
I6H49_RS09590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H49_RS09615	COG1854	S-ribosylhomocysteine lyase activity
I6H49_RS09625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H49_RS09645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6H49_RS09660	COG2733	membrane
I6H49_RS09670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H49_RS09675	COG1053	succinate dehydrogenase
I6H49_RS09685	COG1396	sequence-specific DNA binding
I6H49_RS09685	COG3800	Transcriptional regulator
I6H49_RS09690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H49_RS09710	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H49_RS09725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H49_RS09725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H49_RS09750	COG0318	PFAM AMP-dependent synthetase and ligase
I6H49_RS09755	COG2190	(PTS) system
I6H49_RS09755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H49_RS09755	COG1263	PTS System
I6H49_RS09760	COG0363	glucosamine-6-phosphate deaminase activity
I6H49_RS09765	COG0402	S-adenosylhomocysteine deaminase activity
I6H49_RS09780	COG0740	serine-type endopeptidase activity
I6H49_RS09855	COG4974	Belongs to the 'phage' integrase family
I6H49_RS09865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H49_RS09880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H49_RS09880	COG1754	DNA topoisomerase type I activity
I6H49_RS09890	COG1278	Cold shock
I6H49_RS09895	COG1205	dead DEAH box helicase
I6H49_RS09895	COG1111	helicase
I6H49_RS09960	COG0596	Alpha beta hydrolase
I6H49_RS09965	COG4166	transmembrane transport
I6H49_RS09970	COG0601	transmembrane transport
I6H49_RS09975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H49_RS09995	COG0494	nUDIX hydrolase
I6H49_RS10000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H49_RS10010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H49_RS10015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H49_RS10020	COG0251	oxidation-reduction process
I6H49_RS10035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H49_RS10045	COG1408	metallophosphoesterase
I6H49_RS10075	COG3949	Membrane
I6H49_RS10085	COG0527	aspartate kinase activity
I6H49_RS10090	COG0697	spore germination
I6H49_RS10120	COG1492	cobalamin metabolic process
I6H49_RS10150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H49_RS10170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H49_RS10185	COG1100	Small GTP-binding protein
I6H49_RS10240	COG0343	queuine tRNA-ribosyltransferase activity
I6H49_RS10245	COG2409	Drug exporters of the RND superfamily
I6H49_RS10265	COG0590	tRNA wobble adenosine to inosine editing
I6H49_RS10275	COG0287	Prephenate dehydrogenase
I6H49_RS10305	COG0523	cobalamin synthesis protein
I6H49_RS10310	COG0471	metal ion transport
I6H49_RS10325	COG0569	domain protein
I6H49_RS10330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H49_RS10335	COG1511	domain protein
I6H49_RS10370	COG3835	regulator
I6H49_RS10375	COG1113	amino acid transport
I6H49_RS10380	COG3961	Belongs to the TPP enzyme family
I6H49_RS10390	COG1950	PFAM Membrane protein of
I6H49_RS10405	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H49_RS10405	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H49_RS10430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H49_RS10450	COG0659	secondary active sulfate transmembrane transporter activity
I6H49_RS10460	COG0604	alcohol dehydrogenase
I6H49_RS10460	COG4221	oxidoreductase activity
I6H49_RS10460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H49_RS10460	COG3321	synthase
I6H49_RS10485	COG1216	Glycosyl transferase, family 2
I6H49_RS10515	COG0277	FAD linked oxidase domain protein
I6H49_RS10540	COG3590	peptidase
I6H49_RS10560	COG2076	Multidrug Resistance protein
I6H49_RS10580	COG2501	S4 domain
I6H49_RS10585	COG1280	lysine exporter protein (LysE YggA)
I6H49_RS10605	COG1643	Atp-dependent helicase
I6H49_RS10610	COG0730	response to heat
I6H49_RS10615	COG3180	Ammonia monooxygenase
I6H49_RS10655	COG1528	Iron-storage protein
I6H49_RS10660	COG0659	secondary active sulfate transmembrane transporter activity
I6H49_RS10665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6H49_RS10670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H49_RS10685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H49_RS10695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H49_RS10700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H49_RS10725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6H49_RS10745	COG3104	oligopeptide transport
I6H49_RS10750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H49_RS10765	COG1716	ATPase activity
I6H49_RS10765	COG1716	ATPase activity
I6H49_RS10770	COG1716	ATPase activity
I6H49_RS10785	COG0768	penicillin binding
I6H49_RS10790	COG0515	serine threonine protein kinase
I6H49_RS10795	COG0515	serine threonine protein kinase
I6H49_RS10795	COG2815	serine threonine protein kinase
I6H49_RS10805	COG0642	Histidine kinase
I6H49_RS10805	COG5002	protein histidine kinase activity
I6H49_RS10815	COG2197	response regulator
I6H49_RS10830	COG1131	(ABC) transporter
I6H49_RS10840	COG4585	Histidine kinase
I6H49_RS10845	COG2197	response regulator
I6H49_RS10865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H49_RS10885	COG1132	(ABC) transporter
I6H49_RS10900	COG0726	polysaccharide deacetylase
I6H49_RS10925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H49_RS10945	COG0187	DNA topoisomerase II activity
I6H49_RS10955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H49_RS10960	COG0592	DNA-directed DNA polymerase activity
I6H49_RS10965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H49_RS10970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H49_RS10975	COG0594	ribonuclease P activity
I6H49_RS10980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H49_RS10995	COG1192	Involved in chromosome partitioning
I6H49_RS11015	COG3409	Peptidoglycan-binding domain 1 protein
I6H49_RS11015	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H49_RS11020	COG3118	belongs to the thioredoxin family
I6H49_RS11055	COG2353	YceI-like domain
I6H49_RS11075	COG0617	tRNA 3'-terminal CCA addition
I6H49_RS11080	COG1678	Uncharacterized ACR, COG1678
I6H49_RS11085	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6H49_RS11120	COG1823	symporter activity
I6H49_RS11130	COG0159	tryptophan synthase activity
I6H49_RS11140	COG0134	indole-3-glycerol-phosphate synthase activity
I6H49_RS11140	COG0135	phosphoribosylanthranilate isomerase activity
I6H49_RS11145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H49_RS11150	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H49_RS11155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H49_RS11170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H49_RS11170	COG1116	anion transmembrane transporter activity
I6H49_RS11185	COG0477	Major facilitator Superfamily
I6H49_RS11190	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H49_RS11200	COG1012	belongs to the aldehyde dehydrogenase family
I6H49_RS11210	COG3971	2-oxopent-4-enoate hydratase activity
I6H49_RS11225	COG1113	amino acid transport
I6H49_RS11240	COG1012	belongs to the aldehyde dehydrogenase family
I6H49_RS11245	COG1228	amidohydrolase
I6H49_RS11300	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H49_RS11305	COG3311	Transcriptional regulator
I6H49_RS11310	COG0495	leucyl-tRNA aminoacylation
I6H49_RS11335	COG1012	belongs to the aldehyde dehydrogenase family
I6H49_RS11335	COG2030	dehydratase
I6H49_RS11340	COG2050	protein possibly involved in aromatic compounds catabolism
I6H49_RS11360	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6H49_RS11375	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H49_RS11380	COG1024	Enoyl-CoA hydratase
I6H49_RS11390	COG1024	Enoyl-CoA hydratase
I6H49_RS11395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H49_RS11400	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H49_RS11405	COG3396	Phenylacetate-CoA oxygenase
I6H49_RS11410	COG3460	Phenylacetate-CoA oxygenase
I6H49_RS11415	COG3396	Phenylacetate-CoA oxygenase
I6H49_RS11425	COG1309	transcriptional regulator
I6H49_RS11440	COG0733	neurotransmitter:sodium symporter activity
I6H49_RS11450	COG0604	alcohol dehydrogenase
I6H49_RS11465	COG2197	response regulator
I6H49_RS11470	COG4585	Histidine kinase
I6H49_RS11475	COG0577	efflux transmembrane transporter activity
I6H49_RS11480	COG1136	(ABC) transporter
I6H49_RS11480	COG0577	efflux transmembrane transporter activity
I6H49_RS11490	COG2826	transposase and inactivated derivatives, IS30 family
I6H49_RS11495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H49_RS11495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H49_RS11505	COG4868	Belongs to the UPF0371 family
I6H49_RS11520	COG1054	Belongs to the UPF0176 family
I6H49_RS11545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H49_RS11560	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H49_RS11565	COG0629	single-stranded DNA binding
I6H49_RS11570	COG0359	binds to the 23S rRNA
I6H49_RS11575	COG0305	Participates in initiation and elongation during chromosome replication
I6H49_RS11585	COG0477	Major facilitator Superfamily
I6H49_RS11590	COG2217	Heavy metal translocating P-type atpase
I6H49_RS11600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H49_RS11605	COG1842	Phage shock protein A
I6H49_RS11620	COG1131	(ABC) transporter
I6H49_RS11660	COG0564	pseudouridine synthase activity
I6H49_RS11685	COG0706	membrane insertase activity
I6H49_RS11690	COG3764	Sortase (surface protein transpeptidase)
I6H49_RS11705	COG4585	Histidine kinase
I6H49_RS11710	COG2197	response regulator
I6H49_RS11735	COG2814	Major facilitator Superfamily
I6H49_RS11740	COG0583	DNA-binding transcription factor activity
I6H49_RS11745	COG0003	Pfam Anion-transporting ATPase
I6H49_RS11750	COG1002	Type II restriction enzyme, methylase subunits
I6H49_RS11760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H49_RS11775	COG0584	glycerophosphoryl diester phosphodiesterase
I6H49_RS11785	COG1316	TRANSCRIPTIONal
I6H49_RS11800	COG0077	Prephenate dehydratase
I6H49_RS11820	COG2188	Transcriptional regulator
I6H49_RS11825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H49_RS11835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6H49_RS11840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H49_RS11845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H49_RS11850	COG0561	phosphatase activity
I6H49_RS11880	COG1216	Glycosyl transferase, family 2
I6H49_RS11885	COG0671	phosphoesterase, PA-phosphatase related
I6H49_RS11890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6H49_RS11895	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6H49_RS11900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H49_RS11905	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H49_RS11905	COG5479	isomerase activity
I6H49_RS11915	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6H49_RS11920	COG0318	PFAM AMP-dependent synthetase and ligase
I6H49_RS11925	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6H49_RS11925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H49_RS11925	COG3321	synthase
I6H49_RS11930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H49_RS11965	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6H49_RS11975	COG0577	efflux transmembrane transporter activity
I6H49_RS11975	COG1136	(ABC) transporter
I6H49_RS11985	COG0438	transferase activity, transferring glycosyl groups
I6H49_RS12005	COG4981	capsule polysaccharide biosynthetic process
I6H49_RS12020	COG1472	Belongs to the glycosyl hydrolase 3 family
I6H49_RS12030	COG1132	(ABC) transporter
I6H49_RS12070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6H49_RS12095	COG0589	response to stress
I6H49_RS12095	COG0475	glutathione-regulated potassium exporter activity
I6H49_RS12100	COG0247	lactate metabolic process
I6H49_RS12100	COG2181	nitrate reductase activity
I6H49_RS12135	COG0175	sulfate reduction
I6H49_RS12160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H49_RS12170	COG1012	belongs to the aldehyde dehydrogenase family
I6H49_RS12180	COG0443	Heat shock 70 kDa protein
I6H49_RS12195	COG0789	Transcriptional regulator
I6H49_RS12250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H49_RS12265	COG0191	fructose-bisphosphate aldolase activity
I6H49_RS12270	COG4129	membrane
I6H49_RS12285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H49_RS12310	COG3711	transcriptional antiterminator
I6H49_RS12315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H49_RS12315	COG2190	(PTS) system
I6H49_RS12315	COG1263	PTS System
I6H49_RS12320	COG0280	phosphate acetyltransferase
I6H49_RS12325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H49_RS12335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H49_RS12350	COG1131	(ABC) transporter
I6H49_RS12360	COG2814	Major facilitator Superfamily
I6H49_RS12390	COG0242	peptide deformylase activity
I6H49_RS12410	COG1051	belongs to the nudix hydrolase family
I6H49_RS12430	COG0651	ATP synthesis coupled electron transport
I6H49_RS12440	COG2111	Na H antiporter
I6H49_RS12440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H49_RS12450	COG1297	OPT oligopeptide transporter protein
I6H49_RS12465	COG2326	polyphosphate kinase activity
I6H49_RS12475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H49_RS12490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS