locus-tag	class	description
CPHO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CPHO_RS00010	COG0592	DNA-directed DNA polymerase activity
CPHO_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CPHO_RS00025	COG0187	DNA topoisomerase II activity
CPHO_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPHO_RS00110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CPHO_RS00135	COG2815	serine threonine protein kinase
CPHO_RS00135	COG0515	serine threonine protein kinase
CPHO_RS00140	COG0515	serine threonine protein kinase
CPHO_RS00145	COG0768	penicillin binding
CPHO_RS00160	COG1716	ATPase activity
CPHO_RS00165	COG1716	ATPase activity
CPHO_RS00165	COG1716	ATPase activity
CPHO_RS00275	COG0494	nUDIX hydrolase
CPHO_RS00285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CPHO_RS00295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CPHO_RS00305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPHO_RS00310	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CPHO_RS00320	COG1528	Iron-storage protein
CPHO_RS00330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CPHO_RS00345	COG3180	Ammonia monooxygenase
CPHO_RS00375	COG0730	response to heat
CPHO_RS00380	COG1643	Atp-dependent helicase
CPHO_RS00395	COG1401	restriction endodeoxyribonuclease activity
CPHO_RS00435	COG2501	S4 domain
CPHO_RS00440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPHO_RS00465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPHO_RS00565	COG0514	ATP-dependent DNA helicase (RecQ)
CPHO_RS00575	COG3695	enzyme binding
CPHO_RS00590	COG3527	Alpha-acetolactate decarboxylase
CPHO_RS00620	COG3590	peptidase
CPHO_RS00655	COG0277	FAD linked oxidase domain protein
CPHO_RS00690	COG1216	Glycosyl transferase, family 2
CPHO_RS00725	COG0604	alcohol dehydrogenase
CPHO_RS00765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CPHO_RS00775	COG0315	cyclic pyranopterin monophosphate synthase activity
CPHO_RS00775	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPHO_RS00815	COG0798	PFAM Bile acid sodium symporter
CPHO_RS00820	COG0471	metal ion transport
CPHO_RS00830	COG0569	domain protein
CPHO_RS00830	COG2985	domain, Protein
CPHO_RS00835	COG0287	Prephenate dehydrogenase
CPHO_RS00865	COG2409	Drug exporters of the RND superfamily
CPHO_RS00870	COG0343	queuine tRNA-ribosyltransferase activity
CPHO_RS00885	COG2801	Transposase and inactivated derivatives
CPHO_RS00910	COG2801	Transposase and inactivated derivatives
CPHO_RS00990	COG0659	secondary active sulfate transmembrane transporter activity
CPHO_RS00995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPHO_RS01010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CPHO_RS01025	COG3442	glutamine amidotransferase
CPHO_RS01030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPHO_RS01050	COG0697	spore germination
CPHO_RS01055	COG0527	aspartate kinase activity
CPHO_RS01060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CPHO_RS01070	COG3949	Membrane
CPHO_RS01105	COG1610	YqeY-like protein
CPHO_RS01110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPHO_RS01125	COG0251	oxidation-reduction process
CPHO_RS01130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPHO_RS01135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPHO_RS01150	COG0494	nUDIX hydrolase
CPHO_RS01160	COG4166	transmembrane transport
CPHO_RS01170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPHO_RS01175	COG0601	transmembrane transport
CPHO_RS01180	COG0596	Alpha beta hydrolase
CPHO_RS01235	COG1205	dead DEAH box helicase
CPHO_RS01235	COG1111	helicase
CPHO_RS01250	COG1754	DNA topoisomerase type I activity
CPHO_RS01250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPHO_RS01290	COG0318	PFAM AMP-dependent synthetase and ligase
CPHO_RS01305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPHO_RS01305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CPHO_RS01315	COG1091	dTDP-4-dehydrorhamnose reductase activity
CPHO_RS01320	COG1088	dTDP-glucose 4,6-dehydratase activity
CPHO_RS01340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPHO_RS01375	COG1053	succinate dehydrogenase
CPHO_RS01380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CPHO_RS01390	COG2733	membrane
CPHO_RS01405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CPHO_RS01425	COG1854	S-ribosylhomocysteine lyase activity
CPHO_RS01430	COG2824	Alkylphosphonate utilization operon protein PhnA
CPHO_RS01445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CPHO_RS01480	COG1131	(ABC) transporter
CPHO_RS01610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPHO_RS01615	COG0431	NADPH-dependent FMN reductase
CPHO_RS01630	COG0318	PFAM AMP-dependent synthetase and ligase
CPHO_RS01635	COG0318	PFAM AMP-dependent synthetase and ligase
CPHO_RS01640	COG0318	PFAM AMP-dependent synthetase and ligase
CPHO_RS01645	COG0438	transferase activity, transferring glycosyl groups
CPHO_RS01660	COG5002	protein histidine kinase activity
CPHO_RS01675	COG0248	Ppx GppA phosphatase
CPHO_RS01685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPHO_RS01710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CPHO_RS01715	COG0181	hydroxymethylbilane synthase activity
CPHO_RS01720	COG1648	precorrin-2 dehydrogenase activity
CPHO_RS01720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPHO_RS01725	COG0113	porphobilinogen synthase activity
CPHO_RS01740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CPHO_RS01745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CPHO_RS01765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CPHO_RS01770	COG0406	alpha-ribazole phosphatase activity
CPHO_RS01775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CPHO_RS01780	COG0785	Cytochrome C biogenesis protein
CPHO_RS01790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPHO_RS01815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPHO_RS01820	COG1321	iron dependent repressor
CPHO_RS01820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPHO_RS01825	COG1121	(ABC) transporter
CPHO_RS01830	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPHO_RS01840	COG1321	iron dependent repressor
CPHO_RS01850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CPHO_RS01855	COG4948	Mandelate Racemase Muconate Lactonizing
CPHO_RS01870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CPHO_RS01880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPHO_RS01880	COG0438	transferase activity, transferring glycosyl groups
CPHO_RS01885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPHO_RS01885	COG0438	transferase activity, transferring glycosyl groups
CPHO_RS01890	COG2226	methyltransferase
CPHO_RS01895	COG0644	oxidoreductase
CPHO_RS01900	COG0142	geranyltranstransferase activity
CPHO_RS01935	COG3328	transposase activity
CPHO_RS01970	COG2801	Transposase and inactivated derivatives
CPHO_RS02055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPHO_RS02065	COG2814	Major facilitator Superfamily
CPHO_RS02070	COG0813	purine-nucleoside phosphorylase activity
CPHO_RS02090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPHO_RS02095	COG0250	Participates in transcription elongation, termination and antitermination
CPHO_RS02100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CPHO_RS02105	COG0081	regulation of translation
CPHO_RS02120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CPHO_RS02125	COG0222	ribosome binding
CPHO_RS02145	COG0003	Pfam Anion-transporting ATPase
CPHO_RS02155	COG1966	Carbon starvation protein
CPHO_RS02160	COG1966	Carbon starvation protein
CPHO_RS02170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPHO_RS02185	COG0477	Major facilitator Superfamily
CPHO_RS02190	COG0542	response to heat
CPHO_RS02215	COG1194	a g-specific adenine glycosylase
CPHO_RS02230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPHO_RS02245	COG2847	Copper chaperone PCu(A)C
CPHO_RS02255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CPHO_RS02270	COG1263	PTS System
CPHO_RS02270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPHO_RS02270	COG2190	(PTS) system
CPHO_RS02285	COG0215	cysteine-tRNA ligase activity
CPHO_RS02290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPHO_RS02300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPHO_RS02305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CPHO_RS02305	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CPHO_RS02315	COG1609	Transcriptional regulator
CPHO_RS02335	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CPHO_RS02375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPHO_RS02380	COG1121	(ABC) transporter
CPHO_RS02410	COG0028	Belongs to the TPP enzyme family
CPHO_RS02420	COG0745	RESPONSE REGULATOR receiver
CPHO_RS02425	COG5002	protein histidine kinase activity
CPHO_RS02440	COG3142	Participates in the control of copper homeostasis
CPHO_RS02445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPHO_RS02470	COG2176	DNA-directed DNA polymerase activity
CPHO_RS02490	COG3311	Transcriptional regulator
CPHO_RS02520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPHO_RS02530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPHO_RS02545	COG1607	acyl-coa hydrolase
CPHO_RS02560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CPHO_RS02585	COG1597	lipid kinase activity
CPHO_RS02595	COG0456	acetyltransferase
CPHO_RS02610	COG0581	inorganic phosphate transmembrane transporter activity
CPHO_RS02615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPHO_RS02640	COG0831	urea catabolic process
CPHO_RS02645	COG0832	Belongs to the urease beta subunit family
CPHO_RS02650	COG0804	urea catabolic process
CPHO_RS02655	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CPHO_RS02660	COG0830	nickel cation binding
CPHO_RS02665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CPHO_RS02670	COG0829	nickel cation binding
CPHO_RS02685	COG1120	ATPase activity
CPHO_RS02690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPHO_RS02720	COG1045	serine acetyltransferase
CPHO_RS02730	COG2197	response regulator
CPHO_RS02735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPHO_RS02740	COG2814	Major facilitator Superfamily
CPHO_RS02790	COG1136	(ABC) transporter
CPHO_RS02790	COG0577	efflux transmembrane transporter activity
CPHO_RS02795	COG1136	(ABC) transporter
CPHO_RS02795	COG0577	efflux transmembrane transporter activity
CPHO_RS02800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CPHO_RS02805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CPHO_RS02835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CPHO_RS02840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CPHO_RS02855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPHO_RS02865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CPHO_RS02885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPHO_RS02890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CPHO_RS02900	COG3191	aminopeptidase activity
CPHO_RS02910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CPHO_RS02915	COG1234	tRNA 3'-trailer cleavage
CPHO_RS02950	COG1882	Formate acetyltransferase
CPHO_RS02995	COG3104	oligopeptide transport
CPHO_RS03000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CPHO_RS03055	COG1172	Belongs to the binding-protein-dependent transport system permease family
CPHO_RS03060	COG1129	ABC transporter
CPHO_RS03090	COG1335	isochorismatase
CPHO_RS03095	COG2066	Belongs to the glutaminase family
CPHO_RS03110	COG1376	ErfK ybiS ycfS ynhG family protein
CPHO_RS03120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPHO_RS03125	COG0569	domain protein
CPHO_RS03135	COG4166	transmembrane transport
CPHO_RS03145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CPHO_RS03150	COG1115	amino acid carrier protein
CPHO_RS03155	COG4221	oxidoreductase activity
CPHO_RS03165	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CPHO_RS03205	COG0686	Belongs to the AlaDH PNT family
CPHO_RS03215	COG2346	COG2346, Truncated hemoglobins
CPHO_RS03220	COG0668	transmembrane transport
CPHO_RS03225	COG4221	oxidoreductase activity
CPHO_RS03230	COG2188	Transcriptional regulator
CPHO_RS03245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CPHO_RS03250	COG0698	ribose 5-phosphate isomerase
CPHO_RS03270	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPHO_RS03280	COG0740	serine-type endopeptidase activity
CPHO_RS03285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CPHO_RS03295	COG0039	L-malate dehydrogenase activity
CPHO_RS03300	COG0525	valine-tRNA ligase activity
CPHO_RS03305	COG0285	dihydrofolate synthase activity
CPHO_RS03320	COG0105	UTP biosynthetic process
CPHO_RS03325	COG1530	ribonuclease E activity
CPHO_RS03330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CPHO_RS03335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CPHO_RS03385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CPHO_RS03405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CPHO_RS03420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPHO_RS03425	COG0799	negative regulation of ribosome biogenesis
CPHO_RS03435	COG1307	EDD domain protein, DegV family
CPHO_RS03460	COG1280	lysine exporter protein (LysE YggA)
CPHO_RS03475	COG0268	Binds directly to 16S ribosomal RNA
CPHO_RS03485	COG0481	GTPase activity
CPHO_RS03495	COG1473	amidohydrolase
CPHO_RS03505	COG4172	Belongs to the ABC transporter superfamily
CPHO_RS03510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPHO_RS03515	COG0601	transmembrane transport
CPHO_RS03520	COG0747	negative chemotaxis
CPHO_RS03525	COG2186	Transcriptional regulator
CPHO_RS03530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPHO_RS03540	COG1132	(ABC) transporter
CPHO_RS03550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CPHO_RS03565	COG1022	Amp-dependent synthetase and ligase
CPHO_RS03575	COG1253	flavin adenine dinucleotide binding
CPHO_RS03580	COG1253	flavin adenine dinucleotide binding
CPHO_RS03590	COG1420	regulation of RNA biosynthetic process
CPHO_RS03610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CPHO_RS03625	COG1381	Involved in DNA repair and RecF pathway recombination
CPHO_RS03630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPHO_RS03645	COG0423	glycine-tRNA ligase activity
CPHO_RS03675	COG0358	DNA primase activity
CPHO_RS03685	COG0671	phosphoesterase, PA-phosphatase related
CPHO_RS03690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CPHO_RS03765	COG3328	transposase activity
CPHO_RS03780	COG3328	transposase activity
CPHO_RS03790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CPHO_RS03820	COG2860	membrane
CPHO_RS03850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPHO_RS03860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CPHO_RS03890	COG3323	Protein of unknown function (DUF1653)
CPHO_RS03890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CPHO_RS03910	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CPHO_RS03935	COG2314	TM2 domain
CPHO_RS03940	COG0174	glutamine synthetase
CPHO_RS03945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CPHO_RS03970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CPHO_RS04010	COG0295	cytidine deaminase activity
CPHO_RS04015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPHO_RS04025	COG2390	Transcriptional regulator
CPHO_RS04065	COG5640	endopeptidase activity
CPHO_RS04085	COG0174	glutamine synthetase
CPHO_RS04115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CPHO_RS04120	COG0321	lipoyl(octanoyl) transferase activity
CPHO_RS04130	COG0509	glycine decarboxylation via glycine cleavage system
CPHO_RS04135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CPHO_RS04140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPHO_RS04140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPHO_RS04150	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPHO_RS04165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPHO_RS04170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CPHO_RS04205	COG2010	Cytochrome c
CPHO_RS04210	COG0723	plastoquinol--plastocyanin reductase activity
CPHO_RS04220	COG0791	NLP P60 protein
CPHO_RS04230	COG0438	transferase activity, transferring glycosyl groups
CPHO_RS04235	COG1940	carbohydrate kinase activity
CPHO_RS04250	COG5650	phosphatidylinositol metabolic process
CPHO_RS04260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CPHO_RS04280	COG0142	geranyltranstransferase activity
CPHO_RS04285	COG0456	acetyltransferase
CPHO_RS04310	COG0275	rRNA processing
CPHO_RS04320	COG0768	penicillin binding
CPHO_RS04325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPHO_RS04335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPHO_RS04350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPHO_RS04355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPHO_RS04360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CPHO_RS04365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CPHO_RS04370	COG1496	oxidoreductase activity
CPHO_RS04375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPHO_RS04380	COG1799	cell septum assembly
CPHO_RS04390	COG3599	regulation of cell shape
CPHO_RS04395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CPHO_RS04410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPHO_RS04415	COG0363	glucosamine-6-phosphate deaminase activity
CPHO_RS04430	COG1940	carbohydrate kinase activity
CPHO_RS04440	COG2186	Transcriptional regulator
CPHO_RS04455	COG0444	Belongs to the ABC transporter superfamily
CPHO_RS04460	COG4608	Belongs to the ABC transporter superfamily
CPHO_RS04465	COG0252	asparaginase activity
CPHO_RS04515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPHO_RS04520	COG1739	Uncharacterized protein family UPF0029
CPHO_RS04545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CPHO_RS04570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CPHO_RS04580	COG0131	Imidazoleglycerol-phosphate dehydratase
CPHO_RS04590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CPHO_RS04600	COG0483	inositol monophosphate 1-phosphatase activity
CPHO_RS04605	COG0107	imidazoleglycerol-phosphate synthase activity
CPHO_RS04610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CPHO_RS04620	COG0134	indole-3-glycerol-phosphate synthase activity
CPHO_RS04625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CPHO_RS04630	COG0469	pyruvate kinase activity
CPHO_RS04635	COG0058	SHG alpha-glucan phosphorylase activity
CPHO_RS04650	COG1929	Belongs to the glycerate kinase type-1 family
CPHO_RS04660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPHO_RS04680	COG0571	ribonuclease III activity
CPHO_RS04685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPHO_RS04690	COG1115	amino acid carrier protein
CPHO_RS04725	COG1006	Multisubunit Na H antiporter MnhC subunit
CPHO_RS04730	COG0651	ATP synthesis coupled electron transport
CPHO_RS04755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CPHO_RS04765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPHO_RS04765	COG2755	lipolytic protein G-D-S-L family
CPHO_RS04770	COG0228	four-way junction DNA binding
CPHO_RS04790	COG0336	Belongs to the RNA methyltransferase TrmD family
CPHO_RS04810	COG2022	thiamine diphosphate biosynthetic process
CPHO_RS04820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPHO_RS04825	COG0352	thiamine-phosphate diphosphorylase activity
CPHO_RS04835	COG0681	Belongs to the peptidase S26 family
CPHO_RS04845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CPHO_RS04870	COG4974	Belongs to the 'phage' integrase family
CPHO_RS04885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CPHO_RS04895	COG0233	cytoplasmic translational termination
CPHO_RS04905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CPHO_RS04915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CPHO_RS04920	COG0750	zinc metalloprotease
CPHO_RS04925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CPHO_RS04930	COG0768	penicillin binding
CPHO_RS04960	COG0579	oxidoreductase
CPHO_RS04965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CPHO_RS04975	COG3022	response to hydroperoxide
CPHO_RS04980	COG0442	prolyl-tRNA aminoacylation
CPHO_RS04995	COG0779	Required for maturation of 30S ribosomal subunits
CPHO_RS05010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CPHO_RS05015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CPHO_RS05020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CPHO_RS05030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CPHO_RS05035	COG2977	Belongs to the P-Pant transferase superfamily
CPHO_RS05040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPHO_RS05050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CPHO_RS05055	COG1185	polyribonucleotide nucleotidyltransferase activity
CPHO_RS05065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CPHO_RS05070	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CPHO_RS05075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPHO_RS05080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPHO_RS05090	COG1674	ftsk spoiiie
CPHO_RS05110	COG1058	Belongs to the CinA family
CPHO_RS05110	COG1546	Belongs to the CinA family
CPHO_RS05115	COG1396	sequence-specific DNA binding
CPHO_RS05120	COG1842	Phage shock protein A
CPHO_RS05125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CPHO_RS05130	COG1122	ATPase activity
CPHO_RS05135	COG1268	BioY protein
CPHO_RS05145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CPHO_RS05150	COG2137	regulation of response to DNA damage stimulus
CPHO_RS05155	COG0765	amino acid transport
CPHO_RS05160	COG0765	amino acid transport
CPHO_RS05165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPHO_RS05170	COG1126	abc transporter atp-binding protein
CPHO_RS05190	COG1196	nuclear chromosome segregation
CPHO_RS05205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CPHO_RS05220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPHO_RS05225	COG2233	PERMEase
CPHO_RS05235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPHO_RS05245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPHO_RS05250	COG1349	DNA-binding transcription factor activity
CPHO_RS05265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CPHO_RS05270	COG1643	Atp-dependent helicase
CPHO_RS05285	COG0450	alkyl hydroperoxide reductase
CPHO_RS05290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPHO_RS05315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPHO_RS05320	COG1321	iron dependent repressor
CPHO_RS05350	COG1061	Type III restriction enzyme res subunit
CPHO_RS05400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CPHO_RS05405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CPHO_RS05410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CPHO_RS05420	COG3253	May function as heme-dependent peroxidase
CPHO_RS05485	COG2837	iron assimilation
CPHO_RS05490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPHO_RS05500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPHO_RS05505	COG1560	Kdo2-lipid A biosynthetic process
CPHO_RS05510	COG0438	transferase activity, transferring glycosyl groups
CPHO_RS05530	COG0217	transcriptional regulatory protein
CPHO_RS05535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CPHO_RS05540	COG0632	four-way junction helicase activity
CPHO_RS05545	COG2255	four-way junction helicase activity
CPHO_RS05555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPHO_RS05560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPHO_RS05565	COG0747	negative chemotaxis
CPHO_RS05570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPHO_RS05575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPHO_RS05580	COG0737	Belongs to the 5'-nucleotidase family
CPHO_RS05605	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CPHO_RS05610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPHO_RS05615	COG0124	histidyl-tRNA synthetase
CPHO_RS05635	COG1760	l-serine dehydratase
CPHO_RS05665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CPHO_RS05685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPHO_RS05690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CPHO_RS05695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPHO_RS05705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CPHO_RS05720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPHO_RS05725	COG0006	proline dipeptidase activity
CPHO_RS05730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CPHO_RS05735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPHO_RS05740	COG2326	polyphosphate kinase activity
CPHO_RS05755	COG3842	ATPase activity
CPHO_RS05790	COG0540	Belongs to the ATCase OTCase family
CPHO_RS05795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPHO_RS05805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPHO_RS05810	COG0284	orotidine-5'-phosphate decarboxylase activity
CPHO_RS05825	COG1758	RNA polymerase activity
CPHO_RS05835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CPHO_RS05845	COG0242	peptide deformylase activity
CPHO_RS05850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CPHO_RS05885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CPHO_RS05895	COG0322	excinuclease ABC activity
CPHO_RS05900	COG1660	Displays ATPase and GTPase activities
CPHO_RS05915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPHO_RS05920	COG0126	phosphoglycerate kinase activity
CPHO_RS05930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPHO_RS05935	COG0363	glucosamine-6-phosphate deaminase activity
CPHO_RS05950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPHO_RS05955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPHO_RS06005	COG0396	ATPase activity
CPHO_RS06015	COG0822	iron-sulfur transferase activity
CPHO_RS06025	COG0488	(ABC) transporter
CPHO_RS06040	COG2848	UPF0210 protein
CPHO_RS06045	COG3830	Belongs to the UPF0237 family
CPHO_RS06065	COG0791	NLP P60 protein
CPHO_RS06065	COG3883	PFAM NLP P60 protein
CPHO_RS06070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CPHO_RS06115	COG0167	dihydroorotate dehydrogenase activity
CPHO_RS06125	COG1968	undecaprenyl-diphosphatase activity
CPHO_RS06130	COG0215	cysteine-tRNA ligase activity
CPHO_RS06140	COG0546	phosphoglycolate phosphatase activity
CPHO_RS06145	COG0140	phosphoribosyl-ATP diphosphatase activity
CPHO_RS06150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CPHO_RS06155	COG1027	Aspartate ammonia-lyase
CPHO_RS06160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CPHO_RS06175	COG1362	aminopeptidase activity
CPHO_RS06185	COG1222	aaa ATPase
CPHO_RS06190	COG4122	O-methyltransferase activity
CPHO_RS06200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CPHO_RS06220	COG0805	protein transport
CPHO_RS06240	COG0300	oxidoreductase activity
CPHO_RS06260	COG0463	Glycosyl transferase, family 2
CPHO_RS06280	COG0277	FAD linked oxidase domain protein
CPHO_RS06290	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPHO_RS06295	COG0351	phosphomethylpyrimidine kinase
CPHO_RS06295	COG0352	thiamine-phosphate diphosphorylase activity
CPHO_RS06295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CPHO_RS06305	COG0598	Magnesium transport protein CorA
CPHO_RS06310	COG3268	Saccharopine dehydrogenase
CPHO_RS06320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CPHO_RS06325	COG0513	Belongs to the DEAD box helicase family
CPHO_RS06355	COG1716	ATPase activity
CPHO_RS06360	COG0653	protein targeting
CPHO_RS06370	COG3012	SEC-C Motif Domain Protein
CPHO_RS06405	COG1160	GTP binding
CPHO_RS06410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPHO_RS06420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPHO_RS06425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CPHO_RS06440	COG4974	Belongs to the 'phage' integrase family
CPHO_RS06445	COG0494	nUDIX hydrolase
CPHO_RS06465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CPHO_RS06475	COG0647	UMP catabolic process
CPHO_RS06505	COG2835	tetraacyldisaccharide 4'-kinase activity
CPHO_RS06510	COG0165	Argininosuccinate lyase
CPHO_RS06515	COG0137	argininosuccinate synthase activity
CPHO_RS06520	COG1438	arginine binding
CPHO_RS06525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CPHO_RS06530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CPHO_RS06545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CPHO_RS06555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPHO_RS06555	COG0072	phenylalanine-tRNA ligase activity
CPHO_RS06565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPHO_RS06570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CPHO_RS06575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPHO_RS06580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CPHO_RS06605	COG3973	AAA domain
CPHO_RS06630	COG0237	dephospho-CoA kinase activity
CPHO_RS06635	COG3711	transcriptional antiterminator
CPHO_RS06645	COG0539	negative regulation of cytoplasmic translation
CPHO_RS06670	COG2217	Heavy metal translocating P-type atpase
CPHO_RS06680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPHO_RS06710	COG0742	ribosomal rna small subunit methyltransferase
CPHO_RS06720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CPHO_RS06725	COG1461	Dihydroxyacetone kinase
CPHO_RS06730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CPHO_RS06735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CPHO_RS06745	COG1181	Belongs to the D-alanine--D-alanine ligase family
CPHO_RS06750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CPHO_RS06755	COG0406	alpha-ribazole phosphatase activity
CPHO_RS06755	COG0494	nUDIX hydrolase
CPHO_RS06760	COG0066	3-isopropylmalate dehydratase activity
CPHO_RS06765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CPHO_RS06790	COG0668	transmembrane transport
CPHO_RS06795	COG2239	Acts as a magnesium transporter
CPHO_RS06825	COG0431	NADPH-dependent FMN reductase
CPHO_RS06830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPHO_RS06835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPHO_RS06840	COG1780	Probably involved in ribonucleotide reductase function
CPHO_RS06885	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CPHO_RS06890	COG1132	(ABC) transporter
CPHO_RS06915	COG0123	including yeast histone deacetylase and acetoin utilization protein
CPHO_RS06930	COG1960	acyl-CoA dehydrogenase activity
CPHO_RS06940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CPHO_RS06945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPHO_RS07000	COG1169	isochorismate synthase
CPHO_RS07015	COG1169	isochorismate synthase
CPHO_RS07035	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPHO_RS07055	COG0473	3-isopropylmalate dehydrogenase activity
CPHO_RS07220	COG1660	Displays ATPase and GTPase activities
CPHO_RS07300	COG0629	single-stranded DNA binding
CPHO_RS07355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CPHO_RS07360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CPHO_RS07365	COG0440	acetolactate synthase activity
CPHO_RS07370	COG0028	Belongs to the TPP enzyme family
CPHO_RS07380	COG0129	dihydroxy-acid dehydratase activity
CPHO_RS07395	COG5650	phosphatidylinositol metabolic process
CPHO_RS07405	COG0435	Glutathione S-transferase
CPHO_RS07410	COG0583	DNA-binding transcription factor activity
CPHO_RS07425	COG3949	Membrane
CPHO_RS07435	COG0205	6-phosphofructokinase activity
CPHO_RS07460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CPHO_RS07480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CPHO_RS07485	COG1114	Component of the transport system for branched-chain amino acids
CPHO_RS07505	COG0482	sulfurtransferase activity
CPHO_RS07520	COG3409	Peptidoglycan-binding domain 1 protein
CPHO_RS07520	COG3757	hydrolase, family 25
CPHO_RS07530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CPHO_RS07535	COG2086	electron transfer activity
CPHO_RS07550	COG1119	ATPase activity
CPHO_RS07555	COG0366	Alpha amylase catalytic
CPHO_RS07565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CPHO_RS07585	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CPHO_RS07595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CPHO_RS07600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CPHO_RS07605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CPHO_RS07610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CPHO_RS07615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPHO_RS07620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPHO_RS07625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPHO_RS07630	COG0356	it plays a direct role in the translocation of protons across the membrane
CPHO_RS07655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CPHO_RS07670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CPHO_RS07680	COG0315	cyclic pyranopterin monophosphate synthase activity
CPHO_RS07685	COG0746	molybdenum cofactor guanylyltransferase activity
CPHO_RS07725	COG0083	homoserine kinase activity
CPHO_RS07730	COG0460	homoserine dehydrogenase
CPHO_RS07745	COG0019	diaminopimelate decarboxylase activity
CPHO_RS07750	COG0018	arginyl-trna synthetase
CPHO_RS07755	COG1620	l-lactate permease
CPHO_RS07760	COG0247	lactate metabolic process
CPHO_RS07765	COG1139	Iron-sulfur cluster binding protein
CPHO_RS07770	COG1556	Lactate utilization protein
CPHO_RS07805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CPHO_RS07810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPHO_RS07845	COG1228	amidohydrolase
CPHO_RS07850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CPHO_RS07855	COG2986	histidine ammonia-lyase
CPHO_RS07860	COG1414	Transcriptional regulator
CPHO_RS07865	COG0010	Belongs to the arginase family
CPHO_RS07870	COG2814	Major facilitator Superfamily
CPHO_RS07890	COG2272	Belongs to the type-B carboxylesterase lipase family
CPHO_RS07900	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPHO_RS07900	COG0567	Dehydrogenase, E1 component
CPHO_RS07925	COG1595	DNA-templated transcription, initiation
CPHO_RS07935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CPHO_RS07940	COG0297	glycogen (starch) synthase activity
CPHO_RS07945	COG1621	beta-fructofuranosidase activity
CPHO_RS07965	COG0463	Glycosyl transferase, family 2
CPHO_RS07970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPHO_RS07975	COG1611	Belongs to the LOG family
CPHO_RS07980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPHO_RS07985	COG1113	amino acid transport
CPHO_RS07995	COG1113	amino acid transport
CPHO_RS08005	COG0564	pseudouridine synthase activity
CPHO_RS08035	COG1217	gtp-binding protein TYPA
CPHO_RS08050	COG2354	Protein conserved in bacteria
CPHO_RS08065	COG1921	L-seryl-tRNASec selenium transferase activity
CPHO_RS08075	COG0709	Synthesizes selenophosphate from selenide and ATP
CPHO_RS08080	COG3301	Polysulphide reductase, NrfD
CPHO_RS08085	COG0437	4 iron, 4 sulfur cluster binding
CPHO_RS08095	COG3383	formate dehydrogenase (NAD+) activity
CPHO_RS08095	COG0243	molybdopterin cofactor binding
CPHO_RS08100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CPHO_RS08115	COG0012	GTP binding
CPHO_RS08120	COG0628	permease
CPHO_RS08125	COG1322	Protein conserved in bacteria
CPHO_RS08145	COG1722	exodeoxyribonuclease VII activity
CPHO_RS08160	COG1494	fructose-1,6-bisphosphatase
CPHO_RS08165	COG0114	fumarate hydratase activity
CPHO_RS08225	COG1072	(Pantothenic acid kinase))
CPHO_RS08240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CPHO_RS08285	COG0148	phosphopyruvate hydratase activity
CPHO_RS08300	COG3956	TIGRFAM MazG family protein
CPHO_RS08305	COG0531	amino acid
CPHO_RS08310	COG2837	iron assimilation
CPHO_RS08325	COG1309	transcriptional regulator
CPHO_RS08650	COG3561	AntA/AntB antirepressor
CPHO_RS08685	COG0415	Belongs to the DNA photolyase family
CPHO_RS08690	COG2132	Multicopper oxidase
CPHO_RS08695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPHO_RS08700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPHO_RS08715	COG0193	aminoacyl-tRNA hydrolase activity
CPHO_RS08720	COG2326	polyphosphate kinase activity
CPHO_RS08730	COG0193	aminoacyl-tRNA hydrolase activity
CPHO_RS08740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPHO_RS08765	COG1024	Enoyl-CoA hydratase
CPHO_RS08770	COG0561	phosphatase activity
CPHO_RS08785	COG0488	(ABC) transporter
CPHO_RS08805	COG3583	domain protein
CPHO_RS08810	COG0084	hydrolase, TatD family'
CPHO_RS08825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPHO_RS08830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPHO_RS08840	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CPHO_RS08855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPHO_RS08860	COG0519	Catalyzes the synthesis of GMP from XMP
CPHO_RS08880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CPHO_RS08885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CPHO_RS08895	COG1970	mechanosensitive ion channel activity
CPHO_RS08905	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPHO_RS08905	COG0315	cyclic pyranopterin monophosphate synthase activity
CPHO_RS08910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPHO_RS08915	COG2205	protein histidine kinase activity
CPHO_RS08920	COG0745	RESPONSE REGULATOR receiver
CPHO_RS08930	COG0254	rRNA binding
CPHO_RS08935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CPHO_RS08945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPHO_RS08960	COG1309	transcriptional regulator
CPHO_RS08970	COG0138	bifunctional purine biosynthesis protein purh
CPHO_RS08995	COG1136	(ABC) transporter
CPHO_RS08995	COG0577	efflux transmembrane transporter activity
CPHO_RS09005	COG4942	peptidase
CPHO_RS09015	COG1605	Chorismate mutase
CPHO_RS09020	COG2056	Na+-H+ antiporter family
CPHO_RS09030	COG3304	Inner membrane component domain
CPHO_RS09040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPHO_RS09055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CPHO_RS09075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPHO_RS09080	COG1132	(ABC) transporter
CPHO_RS09095	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CPHO_RS09100	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CPHO_RS09125	COG2801	Transposase and inactivated derivatives
CPHO_RS09140	COG2801	Transposase and inactivated derivatives
CPHO_RS09160	COG0425	Belongs to the sulfur carrier protein TusA family
CPHO_RS09175	COG2391	methyltransferase activity
CPHO_RS09195	COG1201	RNA secondary structure unwinding
CPHO_RS09200	COG1218	3'(2'),5'-bisphosphate nucleotidase
CPHO_RS09205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CPHO_RS09215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CPHO_RS09270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPHO_RS09280	COG0656	L-ascorbic acid biosynthetic process
CPHO_RS09285	COG0545	Peptidyl-prolyl cis-trans isomerase
CPHO_RS09290	COG0372	Belongs to the citrate synthase family
CPHO_RS09310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPHO_RS09315	COG2252	PERMEase
CPHO_RS09335	COG1278	Cold shock
CPHO_RS09340	COG1652	LysM domain
CPHO_RS09415	COG2177	Part of the ABC transporter FtsEX involved in
CPHO_RS09420	COG2884	Cell division ATP-binding protein ftsE
CPHO_RS09425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CPHO_RS09430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CPHO_RS09435	COG1218	3'(2'),5'-bisphosphate nucleotidase
CPHO_RS09440	COG0483	inositol monophosphate 1-phosphatase activity
CPHO_RS09490	COG0702	epimerase
CPHO_RS09520	COG3480	Lon protease (S16) C-terminal proteolytic domain
CPHO_RS09550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CPHO_RS09555	COG1074	ATP-dependent DNA helicase activity
CPHO_RS09610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPHO_RS09620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CPHO_RS09625	COG1162	GTPase activity
CPHO_RS09655	COG0653	protein targeting
CPHO_RS09660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CPHO_RS09670	COG5401	PFAM Sporulation and spore germination
CPHO_RS09675	COG5002	protein histidine kinase activity
CPHO_RS09680	COG0745	RESPONSE REGULATOR receiver
CPHO_RS09705	COG1482	cell wall glycoprotein biosynthetic process
CPHO_RS09725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPHO_RS09755	COG1316	TRANSCRIPTIONal
CPHO_RS09780	COG0733	neurotransmitter:sodium symporter activity
CPHO_RS09795	COG1012	belongs to the aldehyde dehydrogenase family
CPHO_RS09880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPHO_RS09885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPHO_RS09895	COG0424	maF-like protein
CPHO_RS09905	COG0189	ligase activity
CPHO_RS09910	COG2897	thiosulfate sulfurtransferase activity
CPHO_RS09915	COG4770	biotin carboxylase activity
CPHO_RS09925	COG0372	Belongs to the citrate synthase family
CPHO_RS09930	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CPHO_RS09935	COG2079	MmgE PrpD family protein
CPHO_RS09940	COG1396	sequence-specific DNA binding
CPHO_RS09940	COG3800	Transcriptional regulator
CPHO_RS09950	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CPHO_RS09950	COG1473	amidohydrolase
CPHO_RS09960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CPHO_RS09980	COG1686	Belongs to the peptidase S11 family
CPHO_RS09990	COG1295	ribonuclease BN
CPHO_RS09995	COG0180	Tryptophanyl-tRNA synthetase
CPHO_RS10010	COG2814	Major facilitator Superfamily
CPHO_RS10015	COG2838	Isocitrate dehydrogenase
CPHO_RS10040	COG1131	(ABC) transporter
CPHO_RS10065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CPHO_RS10070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPHO_RS10095	COG2873	o-acetylhomoserine
CPHO_RS10110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CPHO_RS10115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CPHO_RS10155	COG0587	DNA-directed DNA polymerase activity
CPHO_RS10160	COG1464	Belongs to the NlpA lipoprotein family
CPHO_RS10165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPHO_RS10170	COG2011	ABC-type metal ion transport system permease component
CPHO_RS10195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPHO_RS10210	COG1136	(ABC) transporter
CPHO_RS10215	COG0577	efflux transmembrane transporter activity
CPHO_RS10230	COG0516	GMP reductase activity
CPHO_RS10270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CPHO_RS10280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CPHO_RS10285	COG0456	acetyltransferase
CPHO_RS10305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPHO_RS10345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPHO_RS10360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CPHO_RS10385	COG1674	ftsk spoiiie
CPHO_RS10395	COG1404	Belongs to the peptidase S8 family
CPHO_RS10415	COG0203	ribosomal protein L17
CPHO_RS10425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CPHO_RS10430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CPHO_RS10455	COG0563	adenylate kinase activity
CPHO_RS10460	COG0201	protein transport
CPHO_RS10470	COG0200	Binds to the 23S rRNA
CPHO_RS10475	COG1841	ribosomal large subunit assembly
CPHO_RS10480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CPHO_RS10485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CPHO_RS10505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CPHO_RS10515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CPHO_RS10520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CPHO_RS10535	COG1160	GTP binding
CPHO_RS10565	COG0747	negative chemotaxis
CPHO_RS10585	COG1518	maintenance of DNA repeat elements
CPHO_RS10610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CPHO_RS10615	COG0255	Belongs to the universal ribosomal protein uL29 family
CPHO_RS10620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CPHO_RS10625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CPHO_RS10630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CPHO_RS10635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CPHO_RS10640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CPHO_RS10645	COG0089	rRNA binding
CPHO_RS10650	COG0088	Forms part of the polypeptide exit tunnel
CPHO_RS10655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CPHO_RS10660	COG0051	transcription antitermination factor activity, RNA binding
CPHO_RS10700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPHO_RS10705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPHO_RS10710	COG0049	tRNA binding
CPHO_RS10715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CPHO_RS10725	COG3833	ABC-type maltose transport systems, permease component
CPHO_RS10730	COG1175	transmembrane transport
CPHO_RS10740	COG0366	Alpha amylase catalytic
CPHO_RS10745	COG1523	belongs to the glycosyl hydrolase 13 family
CPHO_RS10755	COG3842	ATPase activity
CPHO_RS10770	COG1122	ATPase activity
CPHO_RS10775	COG4721	ABC-type cobalt transport system, permease component
CPHO_RS10780	COG4721	ABC-type cobalt transport system, permease component
CPHO_RS10790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CPHO_RS10805	COG0156	8-amino-7-oxononanoate synthase activity
CPHO_RS10810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPHO_RS10835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CPHO_RS10845	COG0302	gtp cyclohydrolase
CPHO_RS10850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPHO_RS10860	COG0037	tRNA processing
CPHO_RS10865	COG2027	D-alanyl-D-alanine carboxypeptidase
CPHO_RS10870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CPHO_RS10890	COG2326	polyphosphate kinase activity
CPHO_RS10900	COG0459	protein refolding
CPHO_RS10915	COG1297	OPT oligopeptide transporter protein
CPHO_RS10930	COG2111	Na H antiporter
CPHO_RS10930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPHO_RS10935	COG1006	Multisubunit Na H antiporter MnhC subunit
CPHO_RS10940	COG0651	ATP synthesis coupled electron transport
CPHO_RS10955	COG1320	monovalent cation:proton antiporter activity
CPHO_RS10960	COG1051	belongs to the nudix hydrolase family
CPHO_RS10985	COG0242	peptide deformylase activity
CPHO_RS10995	COG0708	Exodeoxyribonuclease III
CPHO_RS11000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPHO_RS11005	COG2814	Major facilitator Superfamily
CPHO_RS11015	COG1131	(ABC) transporter
CPHO_RS11030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPHO_RS11045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CPHO_RS11050	COG0280	phosphate acetyltransferase
CPHO_RS11060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CPHO_RS11080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPHO_RS11085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CPHO_RS11110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CPHO_RS11120	COG4129	membrane
CPHO_RS11125	COG0191	fructose-bisphosphate aldolase activity
CPHO_RS11155	COG0542	response to heat
CPHO_RS11170	COG1174	glycine betaine transport
CPHO_RS11175	COG1174	glycine betaine transport
CPHO_RS11180	COG0517	IMP dehydrogenase activity
CPHO_RS11180	COG1125	glycine betaine transport
CPHO_RS11205	COG1012	belongs to the aldehyde dehydrogenase family
CPHO_RS11210	COG0701	Predicted permease
CPHO_RS11220	COG0789	Transcriptional regulator
CPHO_RS11230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CPHO_RS11235	COG0443	Heat shock 70 kDa protein
CPHO_RS11260	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CPHO_RS11260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CPHO_RS11270	COG1535	isochorismatase
CPHO_RS11270	COG3433	isochorismatase activity
CPHO_RS11275	COG1021	2,3-dihydroxybenzoate-AMP ligase
CPHO_RS11280	COG1169	isochorismate synthase
CPHO_RS11285	COG3433	isochorismatase activity
CPHO_RS11285	COG1535	isochorismatase
CPHO_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
CPHO_RS11295	COG2181	nitrate reductase activity
CPHO_RS11295	COG0247	lactate metabolic process
CPHO_RS11325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CPHO_RS11330	COG0717	Belongs to the dCTP deaminase family
CPHO_RS11340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CPHO_RS11355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CPHO_RS11370	COG1201	RNA secondary structure unwinding
CPHO_RS11375	COG0210	DNA helicase
CPHO_RS11405	COG3328	transposase activity
CPHO_RS11465	COG1472	Belongs to the glycosyl hydrolase 3 family
CPHO_RS11480	COG4981	capsule polysaccharide biosynthetic process
CPHO_RS11500	COG0438	transferase activity, transferring glycosyl groups
CPHO_RS11505	COG0500	methyltransferase
CPHO_RS11510	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CPHO_RS11515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CPHO_RS11550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPHO_RS11555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPHO_RS11555	COG3321	synthase
CPHO_RS11555	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CPHO_RS11575	COG0318	PFAM AMP-dependent synthetase and ligase
CPHO_RS11580	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CPHO_RS11590	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPHO_RS11590	COG5479	isomerase activity
CPHO_RS11610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CPHO_RS11615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CPHO_RS11625	COG1216	Glycosyl transferase, family 2
CPHO_RS11645	COG1120	ATPase activity
CPHO_RS11650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPHO_RS11655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPHO_RS11670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPHO_RS11690	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CPHO_RS11745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPHO_RS11755	COG0561	phosphatase activity
CPHO_RS11765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CPHO_RS11770	COG2188	Transcriptional regulator
CPHO_RS11790	COG0077	Prephenate dehydratase
CPHO_RS11805	COG1316	TRANSCRIPTIONal
CPHO_RS11815	COG0584	glycerophosphoryl diester phosphodiesterase
CPHO_RS11820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPHO_RS11830	COG2814	Major facilitator Superfamily
CPHO_RS11855	COG2197	response regulator
CPHO_RS11860	COG4585	Histidine kinase
CPHO_RS11870	COG3764	Sortase (surface protein transpeptidase)
CPHO_RS11875	COG0706	membrane insertase activity
CPHO_RS11880	COG1309	transcriptional regulator
CPHO_RS11885	COG2261	transglycosylase associated protein
CPHO_RS11930	COG1131	(ABC) transporter
CPHO_RS11945	COG1842	Phage shock protein A
CPHO_RS11950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPHO_RS11960	COG2217	Heavy metal translocating P-type atpase
CPHO_RS11965	COG0477	Major facilitator Superfamily
CPHO_RS11975	COG0305	Participates in initiation and elongation during chromosome replication
CPHO_RS11980	COG0359	binds to the 23S rRNA
CPHO_RS11990	COG0360	Binds together with S18 to 16S ribosomal RNA
CPHO_RS12005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPHO_RS12045	COG1054	Belongs to the UPF0176 family
CPHO_RS12070	COG1054	Belongs to the UPF0176 family
CPHO_RS12075	COG4868	Belongs to the UPF0371 family
CPHO_RS12085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPHO_RS12085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CPHO_RS12095	COG1136	(ABC) transporter
CPHO_RS12105	COG4585	Histidine kinase
CPHO_RS12110	COG2197	response regulator
CPHO_RS12145	COG0495	leucyl-tRNA aminoacylation
CPHO_RS12155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CPHO_RS12185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CPHO_RS12190	COG0512	Glutamine amidotransferase of anthranilate synthase
CPHO_RS12200	COG0134	indole-3-glycerol-phosphate synthase activity
CPHO_RS12200	COG0135	phosphoribosylanthranilate isomerase activity
CPHO_RS12210	COG0159	tryptophan synthase activity
CPHO_RS12245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPHO_RS12265	COG3961	Belongs to the TPP enzyme family
CPHO_RS12270	COG1113	amino acid transport
CPHO_RS12280	COG1012	belongs to the aldehyde dehydrogenase family
CPHO_RS12300	COG3971	2-oxopent-4-enoate hydratase activity
CPHO_RS12310	COG1012	belongs to the aldehyde dehydrogenase family
CPHO_RS12315	COG1802	Transcriptional regulator
CPHO_RS12325	COG0477	Major facilitator Superfamily
CPHO_RS12350	COG3396	Phenylacetate-CoA oxygenase
CPHO_RS12355	COG3460	Phenylacetate-CoA oxygenase
CPHO_RS12360	COG3396	Phenylacetate-CoA oxygenase
CPHO_RS12365	COG2151	metal-sulfur cluster biosynthetic enzyme
CPHO_RS12370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CPHO_RS12375	COG1024	Enoyl-CoA hydratase
CPHO_RS12385	COG1024	Enoyl-CoA hydratase
CPHO_RS12390	COG1250	3-hydroxyacyl-CoA dehydrogenase
CPHO_RS12395	COG2050	protein possibly involved in aromatic compounds catabolism
CPHO_RS12400	COG2030	dehydratase
CPHO_RS12400	COG1012	belongs to the aldehyde dehydrogenase family
CPHO_RS12450	COG1687	branched-chain amino acid
CPHO_RS12455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CPHO_RS12460	COG1678	Uncharacterized ACR, COG1678
CPHO_RS12465	COG0617	tRNA 3'-terminal CCA addition
CPHO_RS12495	COG2353	YceI-like domain
CPHO_RS12515	COG3118	belongs to the thioredoxin family
CPHO_RS12520	COG3409	Peptidoglycan-binding domain 1 protein
CPHO_RS12520	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPHO_RS12530	COG1475	DNA binding
CPHO_RS12535	COG1192	Involved in chromosome partitioning
CPHO_RS12540	COG0357	Ribosomal RNA small subunit methyltransferase G
CPHO_RS12550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPHO_RS12555	COG0594	ribonuclease P activity
CPHO_RS12560	COG0230	Belongs to the bacterial ribosomal protein bL34 family