locus-tag	class	description
I6I70_RS00010	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS00015	COG2258	MOSC domain
I6I70_RS00025	COG3971	2-oxopent-4-enoate hydratase activity
I6I70_RS00035	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS00040	COG1802	Transcriptional regulator
I6I70_RS00045	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I70_RS00050	COG0477	Major facilitator Superfamily
I6I70_RS00070	COG2501	S4 domain
I6I70_RS00075	COG4221	oxidoreductase activity
I6I70_RS00080	COG3180	Ammonia monooxygenase
I6I70_RS00115	COG1857	crispr-associated protein
I6I70_RS00130	COG1518	maintenance of DNA repeat elements
I6I70_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I70_RS00180	COG1120	ATPase activity
I6I70_RS00200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I70_RS00215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I70_RS00235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I70_RS00240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS00245	COG4558	Periplasmic binding protein
I6I70_RS00260	COG1716	ATPase activity
I6I70_RS00260	COG1716	ATPase activity
I6I70_RS00265	COG1716	ATPase activity
I6I70_RS00290	COG2815	serine threonine protein kinase
I6I70_RS00290	COG0515	serine threonine protein kinase
I6I70_RS00305	COG1131	(ABC) transporter
I6I70_RS00310	COG2186	Transcriptional regulator
I6I70_RS00345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I70_RS00365	COG0438	transferase activity, transferring glycosyl groups
I6I70_RS00375	COG2801	Transposase and inactivated derivatives
I6I70_RS00380	COG2826	transposase and inactivated derivatives, IS30 family
I6I70_RS00425	COG1132	(ABC) transporter
I6I70_RS00430	COG4152	abc transporter atp-binding protein
I6I70_RS00445	COG2801	Transposase and inactivated derivatives
I6I70_RS00480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I70_RS00485	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6I70_RS00490	COG0187	DNA topoisomerase II activity
I6I70_RS00500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I70_RS00505	COG0592	DNA-directed DNA polymerase activity
I6I70_RS00510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I70_RS00515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I70_RS00520	COG0594	ribonuclease P activity
I6I70_RS00525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I70_RS00535	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I70_RS00540	COG1192	Involved in chromosome partitioning
I6I70_RS00550	COG3409	Peptidoglycan-binding domain 1 protein
I6I70_RS00550	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I70_RS00555	COG3118	belongs to the thioredoxin family
I6I70_RS00565	COG1595	DNA-templated transcription, initiation
I6I70_RS00585	COG0617	tRNA 3'-terminal CCA addition
I6I70_RS00590	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I70_RS00615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I70_RS00630	COG0134	indole-3-glycerol-phosphate synthase activity
I6I70_RS00630	COG0135	phosphoribosylanthranilate isomerase activity
I6I70_RS00640	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I70_RS00645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I70_RS00650	COG1228	amidohydrolase
I6I70_RS00655	COG2986	histidine ammonia-lyase
I6I70_RS00660	COG0010	Belongs to the arginase family
I6I70_RS00665	COG2056	Na+-H+ antiporter family
I6I70_RS00670	COG1131	(ABC) transporter
I6I70_RS00705	COG1121	(ABC) transporter
I6I70_RS00710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I70_RS00750	COG1140	nitrate reductase beta subunit
I6I70_RS00790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I70_RS00795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I70_RS00800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I70_RS00830	COG2204	response regulator
I6I70_RS00845	COG1131	(ABC) transporter
I6I70_RS00855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I70_RS00865	COG2358	TRAP transporter, solute receptor (TAXI family
I6I70_RS00870	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS00880	COG3961	Belongs to the TPP enzyme family
I6I70_RS00885	COG0495	leucyl-tRNA aminoacylation
I6I70_RS00895	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I70_RS00920	COG2801	Transposase and inactivated derivatives
I6I70_RS00930	COG3328	transposase activity
I6I70_RS00945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I70_RS00960	COG2895	sulfate adenylyltransferase (ATP) activity
I6I70_RS00970	COG0730	response to heat
I6I70_RS00975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I70_RS00975	COG1648	precorrin-2 dehydrogenase activity
I6I70_RS01000	COG1126	abc transporter atp-binding protein
I6I70_RS01010	COG2197	response regulator
I6I70_RS01015	COG4585	Histidine kinase
I6I70_RS01035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I70_RS01040	COG0569	domain protein
I6I70_RS01060	COG4585	Histidine kinase
I6I70_RS01065	COG2197	response regulator
I6I70_RS01070	COG1131	(ABC) transporter
I6I70_RS01090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I70_RS01090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I70_RS01100	COG4868	Belongs to the UPF0371 family
I6I70_RS01105	COG1054	Belongs to the UPF0176 family
I6I70_RS01125	COG1260	myo-inositol-1-phosphate synthase
I6I70_RS01130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I70_RS01145	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I70_RS01150	COG0629	single-stranded DNA binding
I6I70_RS01155	COG0359	binds to the 23S rRNA
I6I70_RS01160	COG0305	Participates in initiation and elongation during chromosome replication
I6I70_RS01165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I70_RS01170	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I70_RS01180	COG1842	Phage shock protein A
I6I70_RS01220	COG0564	pseudouridine synthase activity
I6I70_RS01240	COG0706	membrane insertase activity
I6I70_RS01245	COG3850	Histidine kinase
I6I70_RS01250	COG2197	response regulator
I6I70_RS01265	COG2814	Major facilitator Superfamily
I6I70_RS01355	COG1316	TRANSCRIPTIONal
I6I70_RS01370	COG0077	Prephenate dehydratase
I6I70_RS01390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I70_RS01400	COG0561	phosphatase activity
I6I70_RS01405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I70_RS01420	COG1216	Glycosyl transferase, family 2
I6I70_RS01425	COG0671	phosphoesterase, PA-phosphatase related
I6I70_RS01430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I70_RS01440	COG5479	isomerase activity
I6I70_RS01440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I70_RS01450	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6I70_RS01455	COG0318	PFAM AMP-dependent synthetase and ligase
I6I70_RS01460	COG3321	synthase
I6I70_RS01460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I70_RS01460	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I70_RS01465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I70_RS01510	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I70_RS01550	COG0438	transferase activity, transferring glycosyl groups
I6I70_RS01590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I70_RS01600	COG1116	anion transmembrane transporter activity
I6I70_RS01605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I70_RS01620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I70_RS01625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I70_RS01635	COG3442	glutamine amidotransferase
I6I70_RS01640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I70_RS01655	COG0527	aspartate kinase activity
I6I70_RS01660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I70_RS01665	COG3949	Membrane
I6I70_RS01695	COG2826	transposase and inactivated derivatives, IS30 family
I6I70_RS01720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I70_RS01735	COG0251	oxidation-reduction process
I6I70_RS01745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I70_RS01755	COG0494	nUDIX hydrolase
I6I70_RS01765	COG0596	Alpha beta hydrolase
I6I70_RS01815	COG1111	helicase
I6I70_RS01815	COG1205	dead DEAH box helicase
I6I70_RS01820	COG1278	Cold shock
I6I70_RS01825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I70_RS01825	COG1754	DNA topoisomerase type I activity
I6I70_RS01830	COG2311	Membrane
I6I70_RS01840	COG0470	DNA polymerase III
I6I70_RS01860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I70_RS01870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I70_RS01895	COG0318	PFAM AMP-dependent synthetase and ligase
I6I70_RS01905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I70_RS01910	COG0785	Cytochrome C biogenesis protein
I6I70_RS01915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I70_RS01915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I70_RS01930	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I70_RS01940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I70_RS01950	COG1053	succinate dehydrogenase
I6I70_RS01955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I70_RS01965	COG2733	membrane
I6I70_RS01980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I70_RS02025	COG1120	ATPase activity
I6I70_RS02030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS02035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS02045	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6I70_RS02060	COG0318	PFAM AMP-dependent synthetase and ligase
I6I70_RS02065	COG0318	PFAM AMP-dependent synthetase and ligase
I6I70_RS02075	COG0318	PFAM AMP-dependent synthetase and ligase
I6I70_RS02080	COG2826	transposase and inactivated derivatives, IS30 family
I6I70_RS02100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I70_RS02110	COG0438	transferase activity, transferring glycosyl groups
I6I70_RS02120	COG5002	protein histidine kinase activity
I6I70_RS02125	COG0745	RESPONSE REGULATOR receiver
I6I70_RS02145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I70_RS02175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I70_RS02190	COG0113	porphobilinogen synthase activity
I6I70_RS02200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I70_RS02210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I70_RS02215	COG0406	alpha-ribazole phosphatase activity
I6I70_RS02225	COG0785	Cytochrome C biogenesis protein
I6I70_RS02235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I70_RS02255	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I70_RS02260	COG0656	L-ascorbic acid biosynthetic process
I6I70_RS02275	COG4948	Mandelate Racemase Muconate Lactonizing
I6I70_RS02300	COG0438	transferase activity, transferring glycosyl groups
I6I70_RS02300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I70_RS02305	COG2226	methyltransferase
I6I70_RS02320	COG0142	geranyltranstransferase activity
I6I70_RS02350	COG0583	DNA-binding transcription factor activity
I6I70_RS02385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I70_RS02395	COG2832	Protein of unknown function (DUF454)
I6I70_RS02405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I70_RS02410	COG0222	ribosome binding
I6I70_RS02425	COG0085	RNA polymerase activity
I6I70_RS02430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I70_RS02435	COG4721	ABC-type cobalt transport system, permease component
I6I70_RS02440	COG4172	Belongs to the ABC transporter superfamily
I6I70_RS02450	COG0726	polysaccharide deacetylase
I6I70_RS02470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I70_RS02510	COG1302	Protein conserved in bacteria
I6I70_RS02515	COG0051	transcription antitermination factor activity, RNA binding
I6I70_RS02525	COG0088	Forms part of the polypeptide exit tunnel
I6I70_RS02530	COG0089	rRNA binding
I6I70_RS02535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I70_RS02545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I70_RS02555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I70_RS02560	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I70_RS02565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I70_RS02570	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6I70_RS02580	COG1120	ATPase activity
I6I70_RS02585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS02590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS02595	COG1473	amidohydrolase
I6I70_RS02595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I70_RS02600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I70_RS02625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I70_RS02630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I70_RS02635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I70_RS02640	COG1841	ribosomal large subunit assembly
I6I70_RS02650	COG0201	protein transport
I6I70_RS02655	COG0563	adenylate kinase activity
I6I70_RS02665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I70_RS02670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I70_RS02680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I70_RS02690	COG0203	ribosomal protein L17
I6I70_RS02700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I70_RS02705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I70_RS02705	COG1321	iron dependent repressor
I6I70_RS02710	COG1121	(ABC) transporter
I6I70_RS02715	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I70_RS02725	COG0101	tRNA pseudouridine synthase activity
I6I70_RS02735	COG1404	Belongs to the peptidase S8 family
I6I70_RS02785	COG0477	Major facilitator Superfamily
I6I70_RS02790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I70_RS02815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I70_RS02820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I70_RS02840	COG0456	acetyltransferase
I6I70_RS02845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I70_RS02850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I70_RS02880	COG0516	GMP reductase activity
I6I70_RS02890	COG0519	Catalyzes the synthesis of GMP from XMP
I6I70_RS02890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I70_RS02915	COG2072	flavoprotein involved in K transport
I6I70_RS02920	COG0640	Transcriptional regulator
I6I70_RS02925	COG0798	PFAM Bile acid sodium symporter
I6I70_RS02930	COG2011	ABC-type metal ion transport system permease component
I6I70_RS02945	COG0587	DNA-directed DNA polymerase activity
I6I70_RS02955	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS02960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I70_RS02975	COG1414	Transcriptional regulator
I6I70_RS02980	COG4948	Mandelate Racemase Muconate Lactonizing
I6I70_RS02985	COG0738	Major facilitator superfamily
I6I70_RS03000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I70_RS03010	COG0814	amino acid
I6I70_RS03015	COG0028	Belongs to the TPP enzyme family
I6I70_RS03025	COG2860	membrane
I6I70_RS03040	COG0477	Major facilitator Superfamily
I6I70_RS03045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I70_RS03055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I70_RS03065	COG0546	phosphoglycolate phosphatase activity
I6I70_RS03070	COG3842	ATPase activity
I6I70_RS03150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS03155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS03160	COG1120	ATPase activity
I6I70_RS03175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I70_RS03180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I70_RS03190	COG2610	gluconate transmembrane transporter activity
I6I70_RS03195	COG3265	gluconokinase activity
I6I70_RS03210	COG2409	Drug exporters of the RND superfamily
I6I70_RS03215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I70_RS03220	COG0814	amino acid
I6I70_RS03225	COG2838	Isocitrate dehydrogenase
I6I70_RS03230	COG2814	Major facilitator Superfamily
I6I70_RS03240	COG2860	membrane
I6I70_RS03250	COG0180	Tryptophanyl-tRNA synthetase
I6I70_RS03255	COG1295	ribonuclease BN
I6I70_RS03260	COG1686	Belongs to the peptidase S11 family
I6I70_RS03275	COG3883	PFAM NLP P60 protein
I6I70_RS03275	COG0791	NLP P60 protein
I6I70_RS03285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I70_RS03295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I70_RS03295	COG1473	amidohydrolase
I6I70_RS03305	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6I70_RS03310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I70_RS03320	COG4770	biotin carboxylase activity
I6I70_RS03325	COG2897	thiosulfate sulfurtransferase activity
I6I70_RS03330	COG0189	ligase activity
I6I70_RS03340	COG0424	maF-like protein
I6I70_RS03350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I70_RS03360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I70_RS03365	COG0366	Alpha amylase catalytic
I6I70_RS03390	COG3842	ATPase activity
I6I70_RS03415	COG0385	Bile acid
I6I70_RS03420	COG0385	Bile acid
I6I70_RS03425	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS03445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I70_RS03450	COG0601	transmembrane transport
I6I70_RS03455	COG0747	negative chemotaxis
I6I70_RS03460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I70_RS03465	COG1114	Component of the transport system for branched-chain amino acids
I6I70_RS03475	COG1132	(ABC) transporter
I6I70_RS03555	COG1022	Amp-dependent synthetase and ligase
I6I70_RS03565	COG1253	flavin adenine dinucleotide binding
I6I70_RS03580	COG1420	regulation of RNA biosynthetic process
I6I70_RS03585	COG0484	heat shock protein binding
I6I70_RS03620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I70_RS03640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I70_RS03660	COG0423	glycine-tRNA ligase activity
I6I70_RS03685	COG0358	DNA primase activity
I6I70_RS03700	COG3177	Filamentation induced by cAMP protein fic
I6I70_RS03735	COG2826	transposase and inactivated derivatives, IS30 family
I6I70_RS03745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I70_RS03790	COG2851	Citrate transporter
I6I70_RS03800	COG2945	thiolester hydrolase activity
I6I70_RS03840	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I70_RS03880	COG2801	Transposase and inactivated derivatives
I6I70_RS03920	COG3764	Sortase (surface protein transpeptidase)
I6I70_RS03955	COG3314	Sporulation integral membrane protein YlbJ
I6I70_RS04010	COG0671	phosphoesterase, PA-phosphatase related
I6I70_RS04020	COG1063	alcohol dehydrogenase
I6I70_RS04055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I70_RS04060	COG3323	Protein of unknown function (DUF1653)
I6I70_RS04060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I70_RS04090	COG0174	glutamine synthetase
I6I70_RS04095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I70_RS04115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I70_RS04145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I70_RS04150	COG0321	lipoyl(octanoyl) transferase activity
I6I70_RS04160	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I70_RS04175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I70_RS04180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I70_RS04200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I70_RS04215	COG2010	Cytochrome c
I6I70_RS04220	COG0723	plastoquinol--plastocyanin reductase activity
I6I70_RS04225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I70_RS04240	COG1940	carbohydrate kinase activity
I6I70_RS04265	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I70_RS04285	COG0142	geranyltranstransferase activity
I6I70_RS04310	COG0275	rRNA processing
I6I70_RS04320	COG0768	penicillin binding
I6I70_RS04325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I70_RS04335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I70_RS04340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I70_RS04350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I70_RS04360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I70_RS04365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I70_RS04370	COG1496	oxidoreductase activity
I6I70_RS04375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I70_RS04380	COG1799	cell septum assembly
I6I70_RS04390	COG3599	regulation of cell shape
I6I70_RS04395	COG0786	glutamate:sodium symporter activity
I6I70_RS04400	COG1556	Lactate utilization protein
I6I70_RS04410	COG0247	lactate metabolic process
I6I70_RS04420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I70_RS04430	COG1902	pentaerythritol trinitrate reductase activity
I6I70_RS04485	COG0252	asparaginase activity
I6I70_RS04495	COG1620	l-lactate permease
I6I70_RS04535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I70_RS04540	COG1739	Uncharacterized protein family UPF0029
I6I70_RS04560	COG0277	FAD linked oxidase domain protein
I6I70_RS04570	COG0363	glucosamine-6-phosphate deaminase activity
I6I70_RS04580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I70_RS04585	COG1940	carbohydrate kinase activity
I6I70_RS04595	COG2186	Transcriptional regulator
I6I70_RS04610	COG0444	Belongs to the ABC transporter superfamily
I6I70_RS04615	COG4608	Belongs to the ABC transporter superfamily
I6I70_RS04620	COG5640	endopeptidase activity
I6I70_RS04630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I70_RS04635	COG0477	Major facilitator Superfamily
I6I70_RS04640	COG0477	Major facilitator Superfamily
I6I70_RS04645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I70_RS04670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I70_RS04675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I70_RS04680	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I70_RS04690	COG2814	Major facilitator Superfamily
I6I70_RS04695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I70_RS04705	COG0483	inositol monophosphate 1-phosphatase activity
I6I70_RS04710	COG0107	imidazoleglycerol-phosphate synthase activity
I6I70_RS04715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I70_RS04725	COG0134	indole-3-glycerol-phosphate synthase activity
I6I70_RS04730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I70_RS04735	COG0469	pyruvate kinase activity
I6I70_RS04765	COG1929	Belongs to the glycerate kinase type-1 family
I6I70_RS04770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I70_RS04785	COG0571	ribonuclease III activity
I6I70_RS04790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I70_RS04795	COG1115	amino acid carrier protein
I6I70_RS04810	COG1403	HNH endonuclease
I6I70_RS04820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I70_RS04820	COG2111	Na H antiporter
I6I70_RS04825	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I70_RS04830	COG0651	ATP synthesis coupled electron transport
I6I70_RS04835	COG1863	multisubunit Na H antiporter MnhE subunit
I6I70_RS04865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I70_RS04865	COG2755	lipolytic protein G-D-S-L family
I6I70_RS04870	COG0228	four-way junction DNA binding
I6I70_RS04875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I70_RS04880	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I70_RS04900	COG2022	thiamine diphosphate biosynthetic process
I6I70_RS04910	COG2022	thiamine diphosphate biosynthetic process
I6I70_RS04910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I70_RS04920	COG0681	Belongs to the peptidase S26 family
I6I70_RS04940	COG0792	nuclease activity
I6I70_RS04955	COG4974	Belongs to the 'phage' integrase family
I6I70_RS04980	COG0233	cytoplasmic translational termination
I6I70_RS04990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I70_RS05005	COG0750	zinc metalloprotease
I6I70_RS05010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I70_RS05015	COG0768	penicillin binding
I6I70_RS05040	COG0579	oxidoreductase
I6I70_RS05045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I70_RS05055	COG3022	response to hydroperoxide
I6I70_RS05075	COG0779	Required for maturation of 30S ribosomal subunits
I6I70_RS05090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I70_RS05095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I70_RS05100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I70_RS05110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I70_RS05115	COG2977	Belongs to the P-Pant transferase superfamily
I6I70_RS05120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I70_RS05130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I70_RS05135	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I70_RS05145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I70_RS05150	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6I70_RS05155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I70_RS05160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I70_RS05170	COG1674	ftsk spoiiie
I6I70_RS05185	COG1546	Belongs to the CinA family
I6I70_RS05185	COG1058	Belongs to the CinA family
I6I70_RS05190	COG1396	sequence-specific DNA binding
I6I70_RS05195	COG1842	Phage shock protein A
I6I70_RS05205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I70_RS05210	COG2137	regulation of response to DNA damage stimulus
I6I70_RS05215	COG0517	IMP dehydrogenase activity
I6I70_RS05215	COG4175	Glycine betaine
I6I70_RS05220	COG4176	ABC-type proline glycine betaine transport system permease component
I6I70_RS05245	COG1196	nuclear chromosome segregation
I6I70_RS05260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I70_RS05275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I70_RS05280	COG2233	PERMEase
I6I70_RS05285	COG1349	DNA-binding transcription factor activity
I6I70_RS05300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I70_RS05305	COG1643	Atp-dependent helicase
I6I70_RS05320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I70_RS05340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I70_RS05345	COG1321	iron dependent repressor
I6I70_RS05395	COG0483	inositol monophosphate 1-phosphatase activity
I6I70_RS05410	COG0756	dUTP diphosphatase activity
I6I70_RS05420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I70_RS05425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I70_RS05505	COG2837	iron assimilation
I6I70_RS05520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I70_RS05525	COG1560	Kdo2-lipid A biosynthetic process
I6I70_RS05530	COG0438	transferase activity, transferring glycosyl groups
I6I70_RS05550	COG0217	transcriptional regulatory protein
I6I70_RS05555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I70_RS05560	COG0632	four-way junction helicase activity
I6I70_RS05565	COG2255	four-way junction helicase activity
I6I70_RS05575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I70_RS05580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I70_RS05590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I70_RS05595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I70_RS05610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I70_RS05615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I70_RS05620	COG0124	histidyl-tRNA synthetase
I6I70_RS05625	COG1760	l-serine dehydratase
I6I70_RS05650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I70_RS05660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I70_RS05670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I70_RS05680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I70_RS05685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I70_RS05695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I70_RS05700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I70_RS05705	COG2326	polyphosphate kinase activity
I6I70_RS05735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I70_RS05740	COG0505	Belongs to the CarA family
I6I70_RS05745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I70_RS05750	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I70_RS05765	COG1758	RNA polymerase activity
I6I70_RS05770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I70_RS05780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I70_RS05790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I70_RS05820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I70_RS05830	COG0322	excinuclease ABC activity
I6I70_RS05835	COG1660	Displays ATPase and GTPase activities
I6I70_RS05845	COG1481	regulation of sporulation
I6I70_RS05850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I70_RS05855	COG0126	phosphoglycerate kinase activity
I6I70_RS05860	COG0149	triose-phosphate isomerase activity
I6I70_RS05865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I70_RS05910	COG1131	(ABC) transporter
I6I70_RS05935	COG0396	ATPase activity
I6I70_RS05940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I70_RS05945	COG0822	iron-sulfur transferase activity
I6I70_RS05950	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I70_RS05955	COG2197	response regulator
I6I70_RS05960	COG4585	Histidine kinase
I6I70_RS05970	COG1131	(ABC) transporter
I6I70_RS05980	COG0488	(ABC) transporter
I6I70_RS05990	COG2848	UPF0210 protein
I6I70_RS05995	COG3830	Belongs to the UPF0237 family
I6I70_RS06015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I70_RS06025	COG0791	NLP P60 protein
I6I70_RS06025	COG3883	PFAM NLP P60 protein
I6I70_RS06030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I70_RS06060	COG4139	cobalamin transport
I6I70_RS06065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I70_RS06085	COG0167	dihydroorotate dehydrogenase activity
I6I70_RS06095	COG1968	undecaprenyl-diphosphatase activity
I6I70_RS06100	COG0215	cysteine-tRNA ligase activity
I6I70_RS06105	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I70_RS06110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I70_RS06115	COG1027	Aspartate ammonia-lyase
I6I70_RS06130	COG1362	aminopeptidase activity
I6I70_RS06155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6I70_RS06165	COG2378	regulation of single-species biofilm formation
I6I70_RS06175	COG0805	protein transport
I6I70_RS06195	COG0463	Glycosyl transferase, family 2
I6I70_RS06230	COG1252	NADH dehydrogenase
I6I70_RS06235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I70_RS06235	COG0351	phosphomethylpyrimidine kinase
I6I70_RS06235	COG0352	thiamine-phosphate diphosphorylase activity
I6I70_RS06245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I70_RS06250	COG0471	metal ion transport
I6I70_RS06255	COG0513	Belongs to the DEAD box helicase family
I6I70_RS06280	COG1716	ATPase activity
I6I70_RS06285	COG0653	protein targeting
I6I70_RS06295	COG1132	(ABC) transporter
I6I70_RS06310	COG1160	GTP binding
I6I70_RS06320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I70_RS06325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I70_RS06340	COG4974	Belongs to the 'phage' integrase family
I6I70_RS06345	COG0494	nUDIX hydrolase
I6I70_RS06360	COG0497	DNA recombination
I6I70_RS06365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I70_RS06380	COG0647	UMP catabolic process
I6I70_RS06390	COG1525	nuclease
I6I70_RS06425	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I70_RS06430	COG0165	Argininosuccinate lyase
I6I70_RS06435	COG0137	argininosuccinate synthase activity
I6I70_RS06440	COG1438	arginine binding
I6I70_RS06445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I70_RS06450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I70_RS06465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I70_RS06470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I70_RS06485	COG0072	phenylalanine-tRNA ligase activity
I6I70_RS06485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I70_RS06490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I70_RS06495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I70_RS06500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I70_RS06520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I70_RS06545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I70_RS06550	COG1960	acyl-CoA dehydrogenase activity
I6I70_RS06560	COG0237	dephospho-CoA kinase activity
I6I70_RS06565	COG0539	negative regulation of cytoplasmic translation
I6I70_RS06570	COG4166	transmembrane transport
I6I70_RS06575	COG0601	transmembrane transport
I6I70_RS06580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I70_RS06700	COG0742	ribosomal rna small subunit methyltransferase
I6I70_RS06705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I70_RS06710	COG1461	Dihydroxyacetone kinase
I6I70_RS06715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I70_RS06720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I70_RS06730	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I70_RS06735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I70_RS06740	COG0406	alpha-ribazole phosphatase activity
I6I70_RS06740	COG0494	nUDIX hydrolase
I6I70_RS06745	COG0066	3-isopropylmalate dehydratase activity
I6I70_RS06750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I70_RS06755	COG1414	Transcriptional regulator
I6I70_RS06760	COG0415	Belongs to the DNA photolyase family
I6I70_RS06765	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS06805	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I70_RS06815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I70_RS06815	COG0517	IMP dehydrogenase activity
I6I70_RS06825	COG0473	3-isopropylmalate dehydrogenase activity
I6I70_RS06840	COG0156	8-amino-7-oxononanoate synthase activity
I6I70_RS06855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I70_RS06865	COG0028	Belongs to the TPP enzyme family
I6I70_RS06870	COG0668	transmembrane transport
I6I70_RS06900	COG0435	Glutathione S-transferase
I6I70_RS06905	COG3949	Membrane
I6I70_RS06915	COG0205	6-phosphofructokinase activity
I6I70_RS06935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I70_RS06970	COG0482	sulfurtransferase activity
I6I70_RS06985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I70_RS07000	COG1119	ATPase activity
I6I70_RS07030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I70_RS07045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I70_RS07050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I70_RS07055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I70_RS07060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I70_RS07065	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I70_RS07075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I70_RS07090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I70_RS07105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I70_RS07115	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I70_RS07120	COG0746	molybdenum cofactor guanylyltransferase activity
I6I70_RS07130	COG0314	molybdopterin synthase activity
I6I70_RS07155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I70_RS07170	COG0083	homoserine kinase activity
I6I70_RS07175	COG0460	homoserine dehydrogenase
I6I70_RS07180	COG0019	diaminopimelate decarboxylase activity
I6I70_RS07185	COG0018	arginyl-trna synthetase
I6I70_RS07220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I70_RS07225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I70_RS07230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I70_RS07250	COG0010	Belongs to the arginase family
I6I70_RS07255	COG2211	Major facilitator Superfamily
I6I70_RS07270	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I70_RS07275	COG0567	Dehydrogenase, E1 component
I6I70_RS07275	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I70_RS07280	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I70_RS07305	COG1595	DNA-templated transcription, initiation
I6I70_RS07330	COG0463	Glycosyl transferase, family 2
I6I70_RS07335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I70_RS07345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I70_RS07350	COG1113	amino acid transport
I6I70_RS07385	COG1217	gtp-binding protein TYPA
I6I70_RS07400	COG0428	transporter
I6I70_RS07420	COG0012	GTP binding
I6I70_RS07430	COG1322	Protein conserved in bacteria
I6I70_RS07445	COG1570	exodeoxyribonuclease VII activity
I6I70_RS07450	COG1722	exodeoxyribonuclease VII activity
I6I70_RS07460	COG0174	glutamine synthetase
I6I70_RS07470	COG1494	fructose-1,6-bisphosphatase
I6I70_RS07475	COG0114	fumarate hydratase activity
I6I70_RS07480	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I70_RS07510	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I70_RS07515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I70_RS07520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I70_RS07555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I70_RS07565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I70_RS07570	COG1072	(Pantothenic acid kinase))
I6I70_RS07585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I70_RS07595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I70_RS07630	COG0148	phosphopyruvate hydratase activity
I6I70_RS07640	COG3956	TIGRFAM MazG family protein
I6I70_RS07645	COG0531	amino acid
I6I70_RS07670	COG2094	Belongs to the DNA glycosylase MPG family
I6I70_RS07685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I70_RS07690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I70_RS07705	COG0193	aminoacyl-tRNA hydrolase activity
I6I70_RS07710	COG0174	glutamine synthetase
I6I70_RS07715	COG2226	methyltransferase
I6I70_RS07745	COG2801	Transposase and inactivated derivatives
I6I70_RS07780	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I70_RS07815	COG0193	aminoacyl-tRNA hydrolase activity
I6I70_RS07825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I70_RS07860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I70_RS07865	COG2224	Isocitrate lyase
I6I70_RS07870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I70_RS07895	COG0488	(ABC) transporter
I6I70_RS07915	COG3583	domain protein
I6I70_RS07920	COG0084	hydrolase, TatD family'
I6I70_RS07925	COG2807	transmembrane transport
I6I70_RS07935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I70_RS07945	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6I70_RS07960	COG0519	Catalyzes the synthesis of GMP from XMP
I6I70_RS07980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I70_RS07995	COG1970	mechanosensitive ion channel activity
I6I70_RS08010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I70_RS08020	COG0254	rRNA binding
I6I70_RS08025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I70_RS08030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I70_RS08035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I70_RS08045	COG1309	transcriptional regulator
I6I70_RS08055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I70_RS08110	COG1605	Chorismate mutase
I6I70_RS08145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I70_RS08150	COG1201	RNA secondary structure unwinding
I6I70_RS08155	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I70_RS08160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I70_RS08170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I70_RS08180	COG2826	transposase and inactivated derivatives, IS30 family
I6I70_RS08185	COG3757	hydrolase, family 25
I6I70_RS08190	COG0372	Belongs to the citrate synthase family
I6I70_RS08195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I70_RS08200	COG2079	MmgE PrpD family protein
I6I70_RS08210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I70_RS08220	COG0656	L-ascorbic acid biosynthetic process
I6I70_RS08225	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I70_RS08230	COG0372	Belongs to the citrate synthase family
I6I70_RS08255	COG2252	PERMEase
I6I70_RS08270	COG1278	Cold shock
I6I70_RS08275	COG1652	LysM domain
I6I70_RS08355	COG3104	oligopeptide transport
I6I70_RS08375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I70_RS08375	COG2755	lipolytic protein G-D-S-L family
I6I70_RS08385	COG2177	Part of the ABC transporter FtsEX involved in
I6I70_RS08390	COG2884	Cell division ATP-binding protein ftsE
I6I70_RS08395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6I70_RS08400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I70_RS08405	COG0483	inositol monophosphate 1-phosphatase activity
I6I70_RS08410	COG0483	inositol monophosphate 1-phosphatase activity
I6I70_RS08455	COG0601	transmembrane transport
I6I70_RS08460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I70_RS08470	COG3314	Sporulation integral membrane protein YlbJ
I6I70_RS08500	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I70_RS08520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I70_RS08555	COG0513	Belongs to the DEAD box helicase family
I6I70_RS08580	COG1595	DNA-templated transcription, initiation
I6I70_RS08585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I70_RS08590	COG1162	GTPase activity
I6I70_RS08600	COG1011	Hydrolase
I6I70_RS08610	COG0653	protein targeting
I6I70_RS08615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I70_RS08620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I70_RS08625	COG5401	PFAM Sporulation and spore germination
I6I70_RS08630	COG5000	phosphorelay sensor kinase activity
I6I70_RS08630	COG5002	protein histidine kinase activity
I6I70_RS08635	COG0745	RESPONSE REGULATOR receiver
I6I70_RS08655	COG1482	cell wall glycoprotein biosynthetic process
I6I70_RS08690	COG1316	TRANSCRIPTIONal
I6I70_RS08700	COG0183	Belongs to the thiolase family
I6I70_RS08705	COG1024	Enoyl-CoA hydratase
I6I70_RS08705	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I70_RS08710	COG0318	PFAM AMP-dependent synthetase and ligase
I6I70_RS08720	COG1960	acyl-CoA dehydrogenase activity
I6I70_RS08740	COG1473	amidohydrolase
I6I70_RS08755	COG0268	Binds directly to 16S ribosomal RNA
I6I70_RS08775	COG1280	lysine exporter protein (LysE YggA)
I6I70_RS08800	COG1307	EDD domain protein, DegV family
I6I70_RS08805	COG0406	alpha-ribazole phosphatase activity
I6I70_RS08810	COG0799	negative regulation of ribosome biogenesis
I6I70_RS08815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I70_RS08825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I70_RS08830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I70_RS08845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I70_RS08855	COG1530	ribonuclease E activity
I6I70_RS08875	COG0285	dihydrofolate synthase activity
I6I70_RS08890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I70_RS08900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I70_RS08915	COG2826	transposase and inactivated derivatives, IS30 family
I6I70_RS08920	COG0740	serine-type endopeptidase activity
I6I70_RS08930	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I70_RS08940	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I70_RS08940	COG1902	pentaerythritol trinitrate reductase activity
I6I70_RS08945	COG0028	Belongs to the TPP enzyme family
I6I70_RS08970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I70_RS08980	COG4221	oxidoreductase activity
I6I70_RS08990	COG0668	transmembrane transport
I6I70_RS09000	COG0686	Belongs to the AlaDH PNT family
I6I70_RS09015	COG2184	nucleotidyltransferase activity
I6I70_RS09090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I70_RS09095	COG1114	Component of the transport system for branched-chain amino acids
I6I70_RS09105	COG1802	Transcriptional regulator
I6I70_RS09110	COG1643	Atp-dependent helicase
I6I70_RS09115	COG1376	ErfK ybiS ycfS ynhG family protein
I6I70_RS09125	COG1024	Enoyl-CoA hydratase
I6I70_RS09130	COG2066	Belongs to the glutaminase family
I6I70_RS09135	COG1335	isochorismatase
I6I70_RS09165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I70_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
I6I70_RS09210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I70_RS09215	COG1234	tRNA 3'-trailer cleavage
I6I70_RS09220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I70_RS09230	COG3191	aminopeptidase activity
I6I70_RS09245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I70_RS09260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I70_RS09275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I70_RS09290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I70_RS09295	COG2814	Major facilitator Superfamily
I6I70_RS09300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I70_RS09345	COG1136	(ABC) transporter
I6I70_RS09345	COG0577	efflux transmembrane transporter activity
I6I70_RS09350	COG1136	(ABC) transporter
I6I70_RS09350	COG0577	efflux transmembrane transporter activity
I6I70_RS09355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I70_RS09360	COG2197	response regulator
I6I70_RS09365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I70_RS09370	COG1045	serine acetyltransferase
I6I70_RS09405	COG1937	Protein conserved in bacteria
I6I70_RS09445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I70_RS09465	COG0456	acetyltransferase
I6I70_RS09475	COG1597	lipid kinase activity
I6I70_RS09480	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6I70_RS09490	COG0354	folic acid binding
I6I70_RS09500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I70_RS09520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I70_RS09530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I70_RS09550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I70_RS09560	COG0537	adenosine 5'-monophosphoramidase activity
I6I70_RS09565	COG5002	protein histidine kinase activity
I6I70_RS09570	COG0745	RESPONSE REGULATOR receiver
I6I70_RS09605	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I70_RS09625	COG1063	alcohol dehydrogenase
I6I70_RS09640	COG1609	Transcriptional regulator
I6I70_RS09650	COG1121	(ABC) transporter
I6I70_RS09655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I70_RS09665	COG1690	Belongs to the RtcB family
I6I70_RS09675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I70_RS09680	COG0215	cysteine-tRNA ligase activity
I6I70_RS09685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I70_RS09695	COG2847	Copper chaperone PCu(A)C
I6I70_RS09700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I70_RS09715	COG0288	reversible hydration of carbon dioxide
I6I70_RS09720	COG1194	a g-specific adenine glycosylase
I6I70_RS09745	COG2814	Major facilitator Superfamily
I6I70_RS09750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I70_RS09755	COG1966	Carbon starvation protein
I6I70_RS09765	COG0003	Pfam Anion-transporting ATPase
I6I70_RS09770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I70_RS09800	COG0302	gtp cyclohydrolase
I6I70_RS09805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I70_RS09815	COG0037	tRNA processing
I6I70_RS09820	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I70_RS09825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I70_RS09835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I70_RS09840	COG2326	polyphosphate kinase activity
I6I70_RS09870	COG2111	Na H antiporter
I6I70_RS09870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I70_RS09880	COG0651	ATP synthesis coupled electron transport
I6I70_RS09890	COG2212	antiporter activity
I6I70_RS09895	COG1320	monovalent cation:proton antiporter activity
I6I70_RS09905	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I70_RS09920	COG0242	peptide deformylase activity
I6I70_RS09950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I70_RS09955	COG0515	serine threonine protein kinase
I6I70_RS09960	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I70_RS09965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I70_RS09975	COG4129	membrane
I6I70_RS09980	COG0191	fructose-bisphosphate aldolase activity
I6I70_RS10040	COG1136	(ABC) transporter
I6I70_RS10040	COG0577	efflux transmembrane transporter activity
I6I70_RS10045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I70_RS10060	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS10065	COG0789	Transcriptional regulator
I6I70_RS10070	COG0484	heat shock protein binding
I6I70_RS10075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I70_RS10080	COG0443	Heat shock 70 kDa protein
I6I70_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS10120	COG1122	ATPase activity
I6I70_RS10165	COG4592	Periplasmic binding protein
I6I70_RS10170	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I70_RS10170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I70_RS10175	COG3433	isochorismatase activity
I6I70_RS10175	COG1535	isochorismatase
I6I70_RS10180	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I70_RS10190	COG3433	isochorismatase activity
I6I70_RS10190	COG1535	isochorismatase
I6I70_RS10195	COG1120	ATPase activity
I6I70_RS10200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS10205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I70_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
I6I70_RS10240	COG1528	Iron-storage protein
I6I70_RS10245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I70_RS10250	COG0717	Belongs to the dCTP deaminase family
I6I70_RS10270	COG4981	capsule polysaccharide biosynthetic process
I6I70_RS10340	COG0431	NADPH-dependent FMN reductase
I6I70_RS10345	COG4585	Histidine kinase
I6I70_RS10350	COG2197	response regulator
I6I70_RS10355	COG1131	(ABC) transporter
I6I70_RS10385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I70_RS10390	COG0477	Major facilitator Superfamily
I6I70_RS10400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I70_RS10405	COG0343	queuine tRNA-ribosyltransferase activity
I6I70_RS10410	COG2409	Drug exporters of the RND superfamily
I6I70_RS10420	COG2826	transposase and inactivated derivatives, IS30 family
I6I70_RS10430	COG0590	tRNA wobble adenosine to inosine editing
I6I70_RS10430	COG0037	tRNA processing
I6I70_RS10440	COG0287	Prephenate dehydrogenase
I6I70_RS10450	COG0183	Belongs to the thiolase family
I6I70_RS10460	COG2030	dehydratase
I6I70_RS10500	COG1002	Type II restriction enzyme, methylase subunits
I6I70_RS10530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I70_RS10545	COG1921	L-seryl-tRNASec selenium transferase activity
I6I70_RS10555	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I70_RS10565	COG0437	4 iron, 4 sulfur cluster binding
I6I70_RS10570	COG0243	molybdopterin cofactor binding
I6I70_RS10570	COG3383	formate dehydrogenase (NAD+) activity
I6I70_RS10575	COG3383	formate dehydrogenase (NAD+) activity
I6I70_RS10575	COG0243	molybdopterin cofactor binding
I6I70_RS10580	COG1823	symporter activity
I6I70_RS10600	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I70_RS10605	COG2235	arginine
I6I70_RS10625	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I70_RS10640	COG0471	metal ion transport
I6I70_RS10645	COG2239	Acts as a magnesium transporter
I6I70_RS10665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I70_RS10675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I70_RS10685	COG0604	alcohol dehydrogenase
I6I70_RS10705	COG1216	Glycosyl transferase, family 2
I6I70_RS10725	COG0277	FAD linked oxidase domain protein
I6I70_RS10730	COG1028	Short-chain dehydrogenase reductase Sdr
I6I70_RS10770	COG1216	Glycosyl transferase, family 2
I6I70_RS10785	COG3590	peptidase
I6I70_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS10820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I70_RS10835	COG2017	converts alpha-aldose to the beta-anomer
I6I70_RS10855	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I70_RS10865	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I70_RS10870	COG0471	metal ion transport
I6I70_RS10875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I70_RS10885	COG1012	belongs to the aldehyde dehydrogenase family
I6I70_RS10885	COG2030	dehydratase
I6I70_RS10890	COG2050	protein possibly involved in aromatic compounds catabolism
I6I70_RS10895	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I70_RS10900	COG1024	Enoyl-CoA hydratase
I6I70_RS10910	COG1024	Enoyl-CoA hydratase
I6I70_RS10915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I70_RS10920	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I70_RS10925	COG3396	Phenylacetate-CoA oxygenase
I6I70_RS10935	COG3396	Phenylacetate-CoA oxygenase
I6I70_RS10955	COG0477	Major facilitator Superfamily