locus-tag class description Cp29156_RS00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Cp29156_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Cp29156_RS00050 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Cp29156_RS00095 ENOG4107SDZ Galactoside transport system permease protein mglC Cp29156_RS00100 ENOG4105C2J ABC transporter Cp29156_RS00140 ENOG4105E0A ABC, transporter Cp29156_RS00145 ENOG4105TVJ transport system, permease Cp29156_RS00150 ENOG4105DQ5 transport system permease protein Cp29156_RS00155 ENOG4108MES Periplasmic binding protein Cp29156_RS00160 ENOG4105XBB septation inhibitor protein Cp29156_RS00165 ENOG4108DT4 serine threonine protein kinase Cp29156_RS00175 ENOG4105CJN penicillin-binding protein Cp29156_RS00195 ENOG4105TV9 FHA Domain-Containing protein Cp29156_RS00195 ENOG4105TV9 FHA Domain-Containing protein Cp29156_RS00225 ENOG4105E0A ABC, transporter Cp29156_RS00230 ENOG4105EHG Permease protein Cp29156_RS00235 ENOG4105CJW magnesium transporter Cp29156_RS00240 ENOG4105CG3 alpha amylase, catalytic region Cp29156_RS00265 ENOG4105K6V RNA polymerase Cp29156_RS00295 ENOG4108IJ8 ABC transporter Cp29156_RS00305 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Cp29156_RS00325 ENOG4105FYV Amp nucleosidase Cp29156_RS00335 ENOG4107YXZ hydrolase, family 25 Cp29156_RS00360 ENOG4108Z0R Transferase Cp29156_RS00375 ENOG4108URH decarboxylase Cp29156_RS00385 ENOG4105K56 Transcriptional regulator Cp29156_RS00400 ENOG4108KK1 membrane protein AbrB duplication Cp29156_RS00410 ENOG4105EJ9 Membrane Cp29156_RS00415 ENOG4106ETB IIa component Cp29156_RS00425 ENOG4105CQ7 ATP-dependent helicase Cp29156_RS00435 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Cp29156_RS00445 ENOG4105K8R UPF0145 protein Cp29156_RS00450 ENOG410848D S4 domain protein YaaA Cp29156_RS00475 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Cp29156_RS00480 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Cp29156_RS00490 ENOG4105C9K Endothelin-converting enzyme 1 Cp29156_RS00510 ENOG4105J1Z Arabinosyltransferase Cp29156_RS00515 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases Cp29156_RS00520 ENOG4108RG3 short-chain dehydrogenase reductase Cp29156_RS00525 ENOG4105IQ5 FAD linked oxidase domain protein Cp29156_RS00555 ENOG4108MKI Glycosyl transferase, family 2 Cp29156_RS00565 ENOG4105DIK (ABC) transporter Cp29156_RS00570 ENOG4107RPQ ABC transporter Cp29156_RS00575 ENOG4107RBD ABC, transporter Cp29156_RS00580 ENOG4105DSE periplasmic solute binding protein Cp29156_RS00605 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Cp29156_RS00630 ENOG4105C8P )-transporter Cp29156_RS00645 ENOG4105CI1 PTS System Cp29156_RS00655 ENOG4105DSQ Nitric oxide reductase Cp29156_RS00670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Cp29156_RS00685 ENOG4105EVN Prephenate dehydrogenase Cp29156_RS00695 ENOG4108Z6B deaminase Cp29156_RS00705 ENOG4105EYF MMPL domain protein Cp29156_RS00710 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Cp29156_RS00720 ENOG4105C6Z Gluconate Cp29156_RS00725 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Cp29156_RS00730 ENOG4105CPQ Dehydrogenase Cp29156_RS00735 ENOG4105CHR reductase Cp29156_RS00750 ENOG4105XT2 Transcriptional regulator Cp29156_RS00775 ENOG4105C6Z Gluconate Cp29156_RS00780 ENOG4105ZXK Dehydrogenase Cp29156_RS00795 ENOG4105ERH Fumarylacetoacetate hydrolase Cp29156_RS00805 ENOG4105F1K Glutamine amidotransferase Cp29156_RS00810 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Cp29156_RS00830 ENOG4107RHR regulatoR Cp29156_RS00835 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Cp29156_RS00850 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Cp29156_RS00860 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein Cp29156_RS00875 ENOG4105PP6 Membrane Cp29156_RS00880 ENOG4105CFH Aspartokinase Cp29156_RS00885 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein Cp29156_RS00900 ENOG4105CH6 catalase Cp29156_RS00940 ENOG4107QKW extracellular solute-binding protein family 1 Cp29156_RS00950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp29156_RS00955 ENOG4105BZU Histidine kinase Cp29156_RS00975 ENOG4108JPZ Monovalent cation H antiporter subunit D Cp29156_RS00985 ENOG4105D65 subunit l Cp29156_RS00995 ENOG4108NJC Cp29156_RS01035 ENOG4105BZ4 penicillin-binding protein Cp29156_RS01040 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Cp29156_RS01060 ENOG4105IJJ transcriptional regulator, crp fnr family Cp29156_RS01080 ENOG4105P8F nudix hydrolase Cp29156_RS01150 ENOG4108I5C dEAD DEAH box helicase Cp29156_RS01160 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Cp29156_RS01165 ENOG4105EPD Oligopeptide transporter, Opt family Cp29156_RS01175 ENOG4107QRG dna polymerase iii Cp29156_RS01190 ENOG4105CEY Amp-dependent synthetase and ligase Cp29156_RS01200 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Cp29156_RS01210 ENOG4105C1B dTDP-glucose 4-6-dehydratase Cp29156_RS01235 ENOG4107QN2 dihydrolipoyl dehydrogenase Cp29156_RS01240 ENOG4105CFF transcriptional regulator Cp29156_RS01255 ENOG4105E33 succinate dehydrogenase Cp29156_RS01265 ENOG4106BRA Membrane Cp29156_RS01275 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Cp29156_RS01295 ENOG4105C6N Formate acetyltransferase Cp29156_RS01315 ENOG4105CEY Amp-dependent synthetase and ligase Cp29156_RS01330 ENOG4105BZU Histidine kinase Cp29156_RS01335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp29156_RS01355 ENOG4105II7 pyrroline-5-carboxylate reductase Cp29156_RS01375 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Cp29156_RS01405 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Cp29156_RS01420 ENOG4105C59 p-type ATPase Cp29156_RS01430 ENOG4105C1Q protoporphyrinogen oxidase Cp29156_RS01445 ENOG4108RH7 phosphoglycerate mutase Cp29156_RS01455 ENOG4107QIV Cytochrome c biogenesis protein Cp29156_RS01465 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Cp29156_RS01480 ENOG4105EHG Permease protein Cp29156_RS01485 ENOG4105CRE cytochrome C Cp29156_RS01520 ENOG4107TCW O-succinylbenzoate synthase Cp29156_RS01535 ENOG4105BZF Glycosyl transferase (Group 1 Cp29156_RS01545 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Cp29156_RS01550 ENOG4105P52 geranylgeranyl reductase Cp29156_RS01580 ENOG410683Z Preprotein translocase SecE subunit Cp29156_RS01605 ENOG4105CTZ aminopeptidase c Cp29156_RS01610 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Cp29156_RS01630 ENOG4105DSE periplasmic solute binding protein Cp29156_RS01640 ENOG4105DIK (ABC) transporter Cp29156_RS01645 ENOG4105CC5 ABC transporter Cp29156_RS01670 ENOG4105BZU Histidine kinase Cp29156_RS01675 ENOG4105WH1 Two component transcriptional regulator luxr family Cp29156_RS01700 ENOG4108PJD permease Cp29156_RS01770 ENOG4105VBF alkaline shock protein Cp29156_RS01865 ENOG4105C44 Serine transporter Cp29156_RS01870 ENOG4105EJQ L-serine dehydratase Cp29156_RS01875 ENOG4105HDK L-asparaginase Cp29156_RS01880 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Cp29156_RS01930 ENOG4105EG2 ABC transporter, permease Cp29156_RS01955 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Cp29156_RS02005 ENOG4108ZT0 50S ribosomal protein l17 Cp29156_RS02035 ENOG4105EC2 ftsk spoIIIe Cp29156_RS02090 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Cp29156_RS02135 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Cp29156_RS02160 ENOG4107QVP Dehydrogenase Cp29156_RS02205 ENOG4108UMI ABC transporter, permease Cp29156_RS02215 ENOG4105D01 (LipO)protein Cp29156_RS02220 ENOG4105D01 (LipO)protein Cp29156_RS02235 ENOG4105DSE periplasmic solute binding protein Cp29156_RS02240 ENOG4105DIK (ABC) transporter Cp29156_RS02245 ENOG4107RBD ABC, transporter Cp29156_RS02250 ENOG4107RPQ ABC transporter Cp29156_RS02255 ENOG4107R5H iron (metal) dependent repressor, dtxr family Cp29156_RS02260 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Cp29156_RS02265 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Cp29156_RS02300 ENOG4105DQ5 transport system permease protein Cp29156_RS02305 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Cp29156_RS02320 ENOG4105E9K Isocitrate dehydrogenase Cp29156_RS02325 ENOG4105F27 Major Facilitator Cp29156_RS02345 ENOG4105C31 Tryptophanyl-tRNA synthetase Cp29156_RS02350 ENOG4107H3J ribonuclease Cp29156_RS02355 ENOG4105DZ1 carboxypeptidase Cp29156_RS02390 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Cp29156_RS02395 ENOG4107RM1 amidohydrolase Cp29156_RS02420 ENOG4108JIK carboxylase Cp29156_RS02425 ENOG4105KHC sulfurtransferase Cp29156_RS02430 ENOG4105D7Z glutathione synthase Cp29156_RS02435 ENOG4105EXC Acyl-transferase Cp29156_RS02445 ENOG4107WR6 Maf-like protein Cp29156_RS02450 ENOG4108RVA ribokinase Cp29156_RS02455 ENOG4105ETE Transcriptional regulator (LacI family Cp29156_RS02465 ENOG4105D8K carboxyl transferase Cp29156_RS02470 ENOG4105D8K carboxyl transferase Cp29156_RS02475 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Cp29156_RS02525 ENOG4107TB5 TRANSCRIPTIONal Cp29156_RS02545 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Cp29156_RS02570 ENOG4105EIP mannose-6-phosphate isomerase Cp29156_RS02595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp29156_RS02600 ENOG4105BZU Histidine kinase Cp29156_RS02615 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Cp29156_RS02655 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Cp29156_RS02660 ENOG4108RAV Conserved protein Cp29156_RS02665 ENOG4108Z66 YbaK ebsC protein Cp29156_RS02700 ENOG4105C1J atp-dependent rna helicase Cp29156_RS02725 ENOG4105C4R Atp-dependent dna helicase Cp29156_RS02735 ENOG4105E09 nadh pyrophosphatase Cp29156_RS02760 ENOG41063PX domain protein Cp29156_RS02855 ENOG4105C85 amino acid Cp29156_RS02860 ENOG4107QSA Oxaloacetate decarboxylase Cp29156_RS02865 ENOG4107QX3 carboxylase Cp29156_RS02875 ENOG4107QSA Oxaloacetate decarboxylase Cp29156_RS02885 ENOG4107TK4 histidinol-phosphate phosphatase Cp29156_RS02890 ENOG4107TK4 histidinol-phosphate phosphatase Cp29156_RS02905 ENOG4105CFC Transporter Cp29156_RS02915 ENOG4105CAK Cell division ATP-binding protein ftsE Cp29156_RS02920 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) Cp29156_RS02935 ENOG4107B2H carbonic anhydrase Cp29156_RS02950 ENOG4105CM4 permease protein Cp29156_RS02955 ENOG4108IPW abc transporter atp-binding protein Cp29156_RS03005 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Cp29156_RS03010 ENOG4108RN7 integral membrane protein Cp29156_RS03025 ENOG4105WH1 Two component transcriptional regulator luxr family Cp29156_RS03045 ENOG4108VJY integral membrane protein Cp29156_RS03065 ENOG4105D94 Major Facilitator Superfamily Cp29156_RS03070 ENOG4108YYH Nadph-dependent fmn reductase Cp29156_RS03100 ENOG4105D9N nucleoside Cp29156_RS03130 ENOG4108KGH TRANSCRIPTIONal Cp29156_RS03140 ENOG4105DV0 amidase (EC 3.5.1.4 Cp29156_RS03165 ENOG4105FDP GntR family transcriptional regulator Cp29156_RS03180 ENOG4108KP7 hydrolase Cp29156_RS03190 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Cp29156_RS03195 ENOG4105EHG Permease protein Cp29156_RS03210 ENOG4105CXY transporter Cp29156_RS03215 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Cp29156_RS03225 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Cp29156_RS03235 ENOG410602S Transferase Cp29156_RS03245 ENOG4106YN8 Prenyltransferase Cp29156_RS03250 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids Cp29156_RS03265 ENOG4107YB1 Trehalose corynomycolyl transferase Cp29156_RS03280 ENOG4107RCI amp-dependent synthetase and ligase Cp29156_RS03285 ENOG4107EEY synthase Cp29156_RS03290 ENOG4105D8K carboxyl transferase Cp29156_RS03335 ENOG4108M6P methyltransferase Cp29156_RS03340 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Cp29156_RS03350 ENOG4105EXC Acyl-transferase Cp29156_RS03355 ENOG41073B4 coagulation factor 5 8 type domain-containing protein Cp29156_RS03375 ENOG4105C26 Dehydrogenase Cp29156_RS03390 ENOG4105C6Y Udp-glucose 6-dehydrogenase Cp29156_RS03410 ENOG4105CRK lysyL-tRNA synthetase Cp29156_RS03435 ENOG4108YZ9 Urea amidohydrolase subunit gamma Cp29156_RS03440 ENOG4105KI2 Urea amidohydrolase subunit beta Cp29156_RS03445 ENOG4105CQM Urea amidohydrolase subunit alpha Cp29156_RS03450 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Cp29156_RS03455 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Cp29156_RS03460 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Cp29156_RS03465 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Cp29156_RS03475 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) Cp29156_RS03480 ENOG4105E0A ABC, transporter Cp29156_RS03495 ENOG4105DF6 Fe-S oxidoreductase Cp29156_RS03550 ENOG4105CFG Acts as a chaperone (By similarity) Cp29156_RS03565 ENOG4105KNI merR family transcriptional Regulator Cp29156_RS03605 ENOG4105DJY efflux transporter, rnd family, mfp subunit Cp29156_RS03610 ENOG4105C19 ABC transporter Cp29156_RS03615 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp29156_RS03625 ENOG4105DWV Homoserine O-trans-acetylase Cp29156_RS03655 ENOG4105CJ1 ABC, transporter Cp29156_RS03695 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Cp29156_RS03710 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Cp29156_RS03725 ENOG4107RCW fructose-bisphosphate aldolase Cp29156_RS03785 ENOG4108W6G cytochrome C Cp29156_RS03790 ENOG4105EAU Plays a role in nitrite reduction (By similarity) Cp29156_RS03800 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Cp29156_RS03805 ENOG4105CRE cytochrome C Cp29156_RS03835 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Cp29156_RS03840 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Cp29156_RS03860 ENOG4108IJ2 phosphate acetyltransferase Cp29156_RS03875 ENOG4105CT1 (ABC) transporter Cp29156_RS03900 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Cp29156_RS03905 ENOG4105CGK Exodeoxyribonuclease III Cp29156_RS03910 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Cp29156_RS03915 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Cp29156_RS03935 ENOG4108U8T Mannosyltransferase Cp29156_RS03955 ENOG4108JPZ Monovalent cation H antiporter subunit D Cp29156_RS03960 ENOG4105MKQ Monovalent cation H antiporter subunit C Cp29156_RS03965 ENOG4105D65 subunit l Cp29156_RS03985 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Cp29156_RS04005 ENOG4105CSR polyphosphate kinase 2 Cp29156_RS04010 ENOG4105CEY Amp-dependent synthetase and ligase Cp29156_RS04030 ENOG4107QJT sodium dicarboxylate symporter Cp29156_RS04035 ENOG4105VFE sira family Cp29156_RS04040 ENOG4105F0N pyrophosphate phospho-hydrolase Cp29156_RS04055 ENOG4108UGV hypoxanthine phosphoribosyltransferase Cp29156_RS04060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Cp29156_RS04065 ENOG4105EUJ GTP cyclohydrolase i Cp29156_RS04070 ENOG4105EEI dihydropteroate synthase Cp29156_RS04100 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Cp29156_RS04135 ENOG4105CRK lysyL-tRNA synthetase Cp29156_RS04150 ENOG4105DU0 nucleoside hydrolase Cp29156_RS04155 ENOG41080V3 Major Facilitator superfamily Cp29156_RS04185 ENOG4108V9Q carbonic anhydrase Cp29156_RS04195 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Cp29156_RS04215 ENOG4108VJ1 Transcriptional regulator (CarD family Cp29156_RS04235 ENOG4105C2N RNA methyltransferase TrmH family group 3 Cp29156_RS04290 ENOG4105C7K acetolactate synthase Cp29156_RS04320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp29156_RS04325 ENOG4105BZU Histidine kinase Cp29156_RS04335 ENOG4107ZUX Histidine triad (HIT) protein Cp29156_RS04340 ENOG4105C12 Phosphoribosylglycinamide synthetase Cp29156_RS04345 ENOG4105CZN Potassium uptake protein Cp29156_RS04350 ENOG4107ZYR domain protein Cp29156_RS04355 ENOG4105C83 adenylosuccinate lyase Cp29156_RS04375 ENOG4108V06 Glutathione peroxidase Cp29156_RS04380 ENOG410839H phosphoribosylformylglycinamidine synthase Cp29156_RS04385 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Cp29156_RS04390 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Cp29156_RS04400 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp29156_RS04405 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Cp29156_RS04430 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Cp29156_RS04445 ENOG4105CBD Diacylglycerol kinase Cp29156_RS04475 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Cp29156_RS04500 ENOG4108JJ9 ABC, transporter Cp29156_RS04505 ENOG4108JJ9 ABC, transporter Cp29156_RS04510 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Cp29156_RS04515 ENOG4105C4M (Ubiquinol oxidase) subunit I Cp29156_RS04555 ENOG4105D7W serine acetyltransferase Cp29156_RS04610 ENOG4105DSU hydrolase Cp29156_RS04645 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Cp29156_RS04655 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Cp29156_RS04665 ENOG4105DUX Transporter Cp29156_RS04670 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Cp29156_RS04680 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Cp29156_RS04695 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Cp29156_RS04700 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Cp29156_RS04710 ENOG4108SEA Esterase Cp29156_RS04715 ENOG4105FF5 Membrane Cp29156_RS04720 ENOG4108HUF Transporter Cp29156_RS04725 ENOG4105DQ5 transport system permease protein Cp29156_RS04730 ENOG4108U1V ABC transporter, permease Cp29156_RS04735 ENOG4105E0A ABC, transporter Cp29156_RS04740 ENOG4105DUU IucA IucC family protein Cp29156_RS04750 ENOG410836F Transposase Cp29156_RS04775 ENOG4105K5B UPF0225 protein Cp29156_RS04785 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Cp29156_RS04825 ENOG4105C37 (CBS) domain Cp29156_RS04830 ENOG4105C1J atp-dependent rna helicase Cp29156_RS04835 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Cp29156_RS04845 ENOG4105D7N magnesium and cobalt transport protein CorA Cp29156_RS04865 ENOG4105CSH Transporter Cp29156_RS04890 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Cp29156_RS04905 ENOG4105CTK cobaltochelatase, cobn subunit Cp29156_RS04940 ENOG4108RG3 short-chain dehydrogenase reductase Cp29156_RS04955 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Cp29156_RS04965 ENOG4107TMB Transcriptional regulator Cp29156_RS04985 ENOG4105E5F proteasome Cp29156_RS05000 ENOG4105DFM M18 family aminopeptidase Cp29156_RS05020 ENOG4108IJ0 Aspartate ammonia-lyase Cp29156_RS05025 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Cp29156_RS05045 ENOG4105C3R Methionine synthase Cp29156_RS05065 ENOG4107SET aldo keto reductase Cp29156_RS05075 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Cp29156_RS05100 ENOG4108UTZ Dihydroxyacetone kinase Cp29156_RS05105 ENOG4105CMT Dihydroxyacetone kinase Cp29156_RS05115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Cp29156_RS05120 ENOG4105C5H ABC transporter Cp29156_RS05185 ENOG4105ZXU NLP P60 protein Cp29156_RS05215 ENOG4105CAG UPF0210 protein Cp29156_RS05240 ENOG4105VG1 fes assembly suf system protein Cp29156_RS05245 ENOG4108UNV SUF system FeS assembly protein, NifU family Cp29156_RS05255 ENOG4105C3K feS assembly ATPase SufC Cp29156_RS05275 ENOG4107JC6 Membrane Cp29156_RS05300 ENOG4105CV1 Transketolase (EC 2.2.1.1) Cp29156_RS05305 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Cp29156_RS05345 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Cp29156_RS05355 ENOG4105CHW UPF0052 protein Cp29156_RS05365 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Cp29156_RS05395 ENOG4105DJV ribulose-phosphate 3-epimerase Cp29156_RS05410 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Cp29156_RS05450 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Cp29156_RS05460 ENOG4105CD3 dihydroorotase Cp29156_RS05500 ENOG4105DC7 peptidase M24 Cp29156_RS05520 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Cp29156_RS05540 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Cp29156_RS05590 ENOG4108UZX fmn reductase Cp29156_RS05595 ENOG4105EJQ L-serine dehydratase Cp29156_RS05620 ENOG4105C5X domain protein Cp29156_RS05625 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Cp29156_RS05640 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Cp29156_RS05655 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Cp29156_RS05690 ENOG4105C29 acyl-CoA thioesterase Cp29156_RS05705 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Cp29156_RS05720 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase Cp29156_RS05740 ENOG4105DBE peroxidase Cp29156_RS05795 ENOG4105E0X reductase Cp29156_RS05800 ENOG4107JTW chlorite dismutase Cp29156_RS05885 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Cp29156_RS05925 ENOG4105JNJ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Cp29156_RS05930 ENOG4105D3R alkyl hydroperoxide reductase Cp29156_RS05935 ENOG4105C5Q Transcriptional regulator Cp29156_RS05945 ENOG4105CQ7 ATP-dependent helicase Cp29156_RS05965 ENOG4105E98 transcriptional regulator DeoR family Cp29156_RS05970 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Cp29156_RS05975 ENOG4105E98 transcriptional regulator DeoR family Cp29156_RS05980 ENOG4105DE4 1-phosphofructokinase Cp29156_RS05995 ENOG4105KRI phosphocarrier protein (HPr Cp29156_RS06000 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Cp29156_RS06010 ENOG4105C2W permease Cp29156_RS06015 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Cp29156_RS06030 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Cp29156_RS06045 ENOG4105C99 atpase involved in dna repair Cp29156_RS06080 ENOG4107ZYJ bioY protein Cp29156_RS06085 ENOG4108JJB ABC transporter Cp29156_RS06090 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Cp29156_RS06100 ENOG4105WBV Transcriptional regulator Cp29156_RS06135 ENOG4105CN5 Metallo-Beta-Lactamase Cp29156_RS06175 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Cp29156_RS06190 ENOG4107QMU Mate efflux family protein Cp29156_RS06235 ENOG4107XFJ UPF0246 protein Cp29156_RS06240 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Cp29156_RS06245 ENOG4105CNG UPF0061 protein Cp29156_RS06250 ENOG4105CKI cobalamin synthesis protein Cp29156_RS06255 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Cp29156_RS06265 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Cp29156_RS06320 ENOG4105DZP Membrane-associated zinc metalloprotease Cp29156_RS06330 ENOG41068X0 Protein of unknown function (DUF2631) Cp29156_RS06375 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Cp29156_RS06400 ENOG4107QYR Signal peptidase i Cp29156_RS06415 ENOG4105DM4 PTS System Cp29156_RS06425 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Cp29156_RS06430 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Cp29156_RS06450 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Cp29156_RS06485 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Cp29156_RS06510 ENOG4105DCF alanine dehydrogenase Cp29156_RS06515 ENOG4107R37 Glutamate dehydrogenase Cp29156_RS06520 ENOG4105BZW Glycerate kinase Cp29156_RS06535 ENOG4105CH2 amidohydrolase Cp29156_RS06555 ENOG4105CA9 Pyruvate kinase Cp29156_RS06565 ENOG4105DK0 Indole-3-glycerol phosphate synthase Cp29156_RS06585 ENOG4108MWI inositol mono-phosphatase Cp29156_RS06650 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Cp29156_RS06675 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Cp29156_RS06680 ENOG4105C7B Threonine dehydratase Cp29156_RS06720 ENOG4105HDK L-asparaginase Cp29156_RS06740 ENOG4107VQS DivIVA family Cp29156_RS06750 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Cp29156_RS06755 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Cp29156_RS06760 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Cp29156_RS06770 ENOG4105DFU Cell wall formation (By similarity) Cp29156_RS06800 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Cp29156_RS06805 ENOG4105CJN penicillin-binding protein Cp29156_RS06855 ENOG41072RD Membrane Cp29156_RS06860 ENOG4105KYH transcriptional regulatory protein Cp29156_RS06870 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Cp29156_RS06890 ENOG4105DKQ ROK family Cp29156_RS06895 ENOG4105JNK Glycosyl transferase (Group 1 Cp29156_RS06905 ENOG4105K4H Nlp p60 protein Cp29156_RS06955 ENOG4108YZT Adenosylcobinamide kinase Cp29156_RS06960 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Cp29156_RS06970 ENOG4105CM2 brancheD-chain amino acid aminotransferase Cp29156_RS06990 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Cp29156_RS06995 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Cp29156_RS07030 ENOG4105C5F glutamine synthetase Cp29156_RS07095 ENOG4107QMH DNA methylase Cp29156_RS07175 ENOG4105D3Y Na H antiporter Cp29156_RS07180 ENOG4105E09 nadh pyrophosphatase Cp29156_RS07185 ENOG4105D98 threonine synthase Cp29156_RS07210 ENOG4105C5F glutamine synthetase Cp29156_RS07235 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Cp29156_RS07255 ENOG4105EGD dinuclear metal center protein, YbgI family Cp29156_RS07280 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Cp29156_RS07295 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Cp29156_RS07300 ENOG4108YIQ Alpha beta hydrolase Cp29156_RS07325 ENOG4105EN6 Membrane Cp29156_RS07395 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Cp29156_RS07425 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Cp29156_RS07480 ENOG4108IQE Amp-dependent synthetase and ligase Cp29156_RS07495 ENOG4105DGW oligopeptidase A Cp29156_RS07500 ENOG4105EBR Carboxylesterase Cp29156_RS07530 ENOG4105CWM branched-chain amino acid transport system II carrier protein Cp29156_RS07535 ENOG4105DEN Luciferase family Cp29156_RS07545 ENOG4105C94 Transporter Cp29156_RS07560 ENOG4105DEF Extracellular solute-binding protein, family 5 Cp29156_RS07570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Cp29156_RS07575 ENOG4108JQ5 ABC transporter Cp29156_RS07585 ENOG4105DFA alanine racemase domain protein Cp29156_RS07590 ENOG4105CUC YeeE YedE family protein Cp29156_RS07600 ENOG4108EU3 peptide transport system, permease Cp29156_RS07620 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp29156_RS07625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp29156_RS07650 ENOG4105CCF Lysine exporter protein (Lyse ygga) Cp29156_RS07675 ENOG4107Z8D degv family Cp29156_RS07680 ENOG4105CVJ phosphoglycerate mutase Cp29156_RS07690 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Cp29156_RS07705 ENOG4105WD1 Membrane Cp29156_RS07710 ENOG4105D0C transport protein Cp29156_RS07735 ENOG4105C03 ribonuclease Cp29156_RS07750 ENOG4105CIF Ornithine Cyclodeaminase Cp29156_RS07760 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Cp29156_RS07800 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Cp29156_RS07825 ENOG4105EUB pirin domain protein Cp29156_RS07835 ENOG4105MC2 DSBA oxidoreductase Cp29156_RS07845 ENOG4105D8X mechanosensitive ion channel Cp29156_RS07925 ENOG4108M15 ABC transporter Cp29156_RS07930 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Cp29156_RS07935 ENOG4105D22 carbon starvation protein Cp29156_RS07950 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Cp29156_RS07955 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family Cp29156_RS07960 ENOG4105EMU Dehydrogenase Cp29156_RS07980 ENOG4107UBC ErfK ybiS ycfS ynhG family protein Cp29156_RS07990 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Cp29156_RS07995 ENOG4108RWI nicotinamidase Cp29156_RS08040 ENOG4105WH1 Two component transcriptional regulator luxr family Cp29156_RS08090 ENOG4108RQ5 Beta-lactamase domain-containing protein Cp29156_RS08115 ENOG4107RKP Nicotinate phosphoribosyltransferase Cp29156_RS08160 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp29156_RS08170 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp29156_RS08175 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Cp29156_RS08180 ENOG4105WAZ (Glutaredoxin-like protein) NrdH Cp29156_RS08190 ENOG4107RA1 nh(3)-dependent nad( ) synthetase Cp29156_RS08255 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 Cp29156_RS08270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp29156_RS08275 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp29156_RS08305 ENOG4105W49 UPF0434 protein Cp29156_RS08310 ENOG4105CH7 arginosuccinase Cp29156_RS08330 ENOG4105C8Y Acetylornithine aminotransferase Cp29156_RS08345 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Cp29156_RS08375 ENOG41084BS 50S ribosomal protein L35 Cp29156_RS08390 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Cp29156_RS08420 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Cp29156_RS08430 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Cp29156_RS08435 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Cp29156_RS08460 ENOG4105E5Q amino acid AbC transporter Cp29156_RS08465 ENOG4108JEH abc transporter atp-binding protein Cp29156_RS08485 ENOG4106H78 methyltransferase Cp29156_RS08490 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Cp29156_RS08500 ENOG4105DP4 dak2 domain fusion protein ylov Cp29156_RS08505 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Cp29156_RS08510 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Cp29156_RS08595 ENOG4105ERH Fumarylacetoacetate hydrolase Cp29156_RS08615 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Cp29156_RS08680 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) Cp29156_RS08690 ENOG4105CPC Aldo Keto reductase Cp29156_RS08700 ENOG4105CTQ phosphohexokinase Cp29156_RS08710 ENOG4105E0A ABC, transporter Cp29156_RS08715 ENOG4105EHG Permease protein Cp29156_RS08780 ENOG4105C10 Electron transfer flavoprotein Cp29156_RS08800 ENOG4105DKW ABC transporter Cp29156_RS08870 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Cp29156_RS08875 ENOG4105ZA1 atp synthase Cp29156_RS08880 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) Cp29156_RS08930 ENOG4105D6E homoserine dehydrogenase Cp29156_RS08935 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Cp29156_RS08945 ENOG4105DAA L-lactate Cp29156_RS08950 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Cp29156_RS08955 ENOG4107QR9 Iron-sulfur cluster binding protein Cp29156_RS08960 ENOG41080R8 Conserved Protein Cp29156_RS08990 ENOG4105FS7 Transcriptional regulator Cp29156_RS09015 ENOG4105C0D helicase Cp29156_RS09020 ENOG4105CK7 Sodium proline symporter Cp29156_RS09050 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Cp29156_RS09070 ENOG4107WI4 Aldose-1-epimerase Cp29156_RS09090 ENOG4105EBR Carboxylesterase Cp29156_RS09095 ENOG4105F9E Shikimate 5-dehydrogenase Cp29156_RS09105 ENOG4105BZ1 (ABC) transporter Cp29156_RS09110 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Cp29156_RS09120 ENOG4105CJW magnesium transporter Cp29156_RS09150 ENOG4107ZBN O-methyltransferase Cp29156_RS09160 ENOG4107QPH glycogen) synthase Cp29156_RS09165 ENOG4107FQX Alpha-acetolactate decarboxylase Cp29156_RS09190 ENOG4105C3Q Glycosyl transferase, family 2 Cp29156_RS09195 ENOG4105EEI dihydropteroate synthase Cp29156_RS09215 ENOG4105C85 amino acid Cp29156_RS09225 ENOG4105C85 amino acid Cp29156_RS09245 ENOG4108Z4U Ferredoxin Cp29156_RS09265 ENOG4105CI3 gtp-binding protein typa Cp29156_RS09295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Cp29156_RS09300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp29156_RS09305 ENOG4108J59 Extracellular solute-binding protein, family 5 Cp29156_RS09315 ENOG4105CAT Cytidine monophosphate kinase Cp29156_RS09325 ENOG4108JJB ABC transporter Cp29156_RS09330 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein Cp29156_RS09340 ENOG4105CKW Inner membrane protein yedI Cp29156_RS09345 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Cp29156_RS09355 ENOG4105BZ1 (ABC) transporter Cp29156_RS09360 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Cp29156_RS09375 ENOG4105C3G gtp-binding protein Cp29156_RS09485 ENOG4105T1M mycothiol conjugate amidase mca Cp29156_RS09545 ENOG4105DXN mazG family Cp29156_RS09550 ENOG4105D5Q Arginine ornithine antiporter Cp29156_RS09560 ENOG41082JN Transcriptional regulator Cp29156_RS09570 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) Cp29156_RS09575 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Cp29156_RS09580 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Cp29156_RS09585 ENOG4108IUM Glycogen debranching enzyme Cp29156_RS09605 ENOG4105EA8 2-Nitropropane dioxygenase Cp29156_RS09610 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Cp29156_RS09620 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Cp29156_RS09625 ENOG4108HGY Proline imino-peptidase Cp29156_RS09665 ENOG4105CSR polyphosphate kinase 2 Cp29156_RS09680 ENOG4105C5H ABC transporter Cp29156_RS09695 ENOG4106839 domain protein Cp29156_RS09700 ENOG4105F8V Hydrolase, tatD family Cp29156_RS09715 ENOG4108K88 Membrane Cp29156_RS09720 ENOG4105C94 Transporter Cp29156_RS09730 ENOG4105FF9 glycosyl transferase, family 39 Cp29156_RS09740 ENOG4108VGI doxx family Cp29156_RS09760 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Cp29156_RS09785 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Cp29156_RS09790 ENOG4105C0H protease Cp29156_RS09795 ENOG41062D9 Histidine kinase Cp29156_RS09800 ENOG4105ETX regulatoR Cp29156_RS09810 ENOG4105NRA 50s ribosomal protein l31 type b Cp29156_RS09840 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Cp29156_RS09850 ENOG4105DRP amino acid AbC transporter Cp29156_RS09855 ENOG4108Q1T ABC transporter Cp29156_RS09860 ENOG4107UBR Extracellular solute-binding protein family 3 Cp29156_RS09865 ENOG4105CDA abc transporter atp-binding protein Cp29156_RS09915 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Cp29156_RS09925 ENOG4107QRT dEAD DEAH box helicase Cp29156_RS09930 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo Cp29156_RS09945 ENOG4105ZIR glutaredoxin-like protein Cp29156_RS09980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp29156_RS09985 ENOG4108J59 Extracellular solute-binding protein, family 5 Cp29156_RS10010 ENOG4107QI1 Mate efflux family protein Cp29156_RS10025 ENOG4108WKN secreted protein Cp29156_RS10035 ENOG4107QN1 sodium solute Cp29156_RS10045 ENOG4108VUG Enoyl-CoA hydratase Cp29156_RS10050 ENOG4105CV8 reductase Cp29156_RS10065 ENOG41081K0 peptidylprolyl cis-trans isomerase Cp29156_RS10070 ENOG4105BZN citrate synthase Cp29156_RS10090 ENOG4105FCS tRNA rRNA methyltransferase Cp29156_RS10095 ENOG4105C7N Xanthine uracil vitamin C permease Cp29156_RS10120 ENOG4105MS9 Resuscitation-promoting factor Cp29156_RS10130 ENOG4105CFI type iii restriction protein res subunit Cp29156_RS10170 ENOG4105DVE abc transporter atp-binding protein Cp29156_RS10190 ENOG41080RH Thioredoxin Cp29156_RS10205 ENOG41079KZ Major Facilitator Superfamily Cp29156_RS10215 ENOG4105BZP glycoside hydrolase 15-related Cp29156_RS10230 ENOG4107YH6 single-stranded DNA-binding protein Cp29156_RS10255 ENOG4105BZ4 penicillin-binding protein Cp29156_RS10275 ENOG4108RKS Short-chain dehydrogenase reductase Sdr Cp29156_RS10290 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Cp29156_RS10295 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Cp29156_RS10300 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Cp29156_RS10315 ENOG4105ECB domain protein Cp29156_RS10325 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp29156_RS10345 ENOG4105ENE Histidine kinase Cp29156_RS10350 ENOG4105WH1 Two component transcriptional regulator luxr family Cp29156_RS10365 ENOG4105CE4 GlcNAc 6-P deacetylase Cp29156_RS10380 ENOG4107EJG GntR family transcriptional regulator Cp29156_RS10385 ENOG4105DEF Extracellular solute-binding protein, family 5 Cp29156_RS10390 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp29156_RS10400 ENOG4108JQ7 (ABC) transporter Cp29156_RS10405 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Cp29156_RS10445 ENOG4106178 UPF0339 protein Cp29156_RS10460 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Cp29156_RS10470 ENOG4105EWK phytoene Cp29156_RS10480 ENOG4105CRQ synthase (Component I) Cp29156_RS10485 ENOG4105RGK anthranilate synthase component ii Cp29156_RS10495 ENOG4105DK0 Indole-3-glycerol phosphate synthase Cp29156_RS10515 ENOG4105DHU Bile acid Cp29156_RS10525 ENOG4105KMT branched-chain amino acid Cp29156_RS10530 ENOG4108UMN azlc family Cp29156_RS10535 ENOG4108UJU UPF0301 protein Cp29156_RS10540 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Cp29156_RS10560 ENOG4105EMN RNA polymerase sigma factor Cp29156_RS10565 ENOG4105C3M thioredoxin reductase Cp29156_RS10570 ENOG4105K63 Thioredoxin Cp29156_RS10575 ENOG4108E1C hydrolase Cp29156_RS10590 ENOG4107QJE Chromosome Partitioning Protein Cp29156_RS10615 ENOG41084CH 50S ribosomal protein l34