locus-tag	class	description
CP3995_RS00015	COG0592	DNA-directed DNA polymerase activity
CP3995_RS00030	COG0187	DNA topoisomerase II activity
CP3995_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP3995_RS00140	COG1120	ATPase activity
CP3995_RS00145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS00150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS00155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP3995_RS00165	COG2815	serine threonine protein kinase
CP3995_RS00165	COG0515	serine threonine protein kinase
CP3995_RS00170	COG0515	serine threonine protein kinase
CP3995_RS00175	COG0768	penicillin binding
CP3995_RS00195	COG1716	ATPase activity
CP3995_RS00195	COG1716	ATPase activity
CP3995_RS00225	COG1120	ATPase activity
CP3995_RS00230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS00235	COG2239	Acts as a magnesium transporter
CP3995_RS00240	COG0366	Alpha amylase catalytic
CP3995_RS00295	COG0517	IMP dehydrogenase activity
CP3995_RS00295	COG1125	glycine betaine transport
CP3995_RS00300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP3995_RS00320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP3995_RS00330	COG3409	Peptidoglycan-binding domain 1 protein
CP3995_RS00330	COG3757	hydrolase, family 25
CP3995_RS00355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CP3995_RS00380	COG1846	Transcriptional regulator
CP3995_RS00395	COG3180	Ammonia monooxygenase
CP3995_RS00405	COG0730	response to heat
CP3995_RS00420	COG1643	Atp-dependent helicase
CP3995_RS00430	COG0519	Catalyzes the synthesis of GMP from XMP
CP3995_RS00440	COG0393	Putative heavy-metal-binding
CP3995_RS00445	COG2501	S4 domain
CP3995_RS00470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP3995_RS00475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP3995_RS00485	COG3590	peptidase
CP3995_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
CP3995_RS00520	COG0277	FAD linked oxidase domain protein
CP3995_RS00550	COG1216	Glycosyl transferase, family 2
CP3995_RS00560	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP3995_RS00565	COG1121	(ABC) transporter
CP3995_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP3995_RS00575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP3995_RS00580	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP3995_RS00605	COG0604	alcohol dehydrogenase
CP3995_RS00630	COG0471	metal ion transport
CP3995_RS00645	COG1263	PTS System
CP3995_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP3995_RS00650	COG1263	PTS System
CP3995_RS00650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP3995_RS00650	COG2190	(PTS) system
CP3995_RS00675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP3995_RS00680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP3995_RS00695	COG0287	Prephenate dehydrogenase
CP3995_RS00715	COG2409	Drug exporters of the RND superfamily
CP3995_RS00720	COG0343	queuine tRNA-ribosyltransferase activity
CP3995_RS00730	COG2610	gluconate transmembrane transporter activity
CP3995_RS00735	COG3265	gluconokinase activity
CP3995_RS00740	COG1063	alcohol dehydrogenase
CP3995_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
CP3995_RS00755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP3995_RS00780	COG2610	gluconate transmembrane transporter activity
CP3995_RS00785	COG2084	Dehydrogenase
CP3995_RS00800	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP3995_RS00805	COG3442	glutamine amidotransferase
CP3995_RS00810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP3995_RS00825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP3995_RS00830	COG2390	Transcriptional regulator
CP3995_RS00835	COG0813	purine-nucleoside phosphorylase activity
CP3995_RS00850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP3995_RS00880	COG0697	spore germination
CP3995_RS00885	COG0527	aspartate kinase activity
CP3995_RS00945	COG1840	ABC-type Fe3 transport system, periplasmic component
CP3995_RS00950	COG2271	Major facilitator Superfamily
CP3995_RS00960	COG3852	Histidine kinase
CP3995_RS00980	COG0651	ATP synthesis coupled electron transport
CP3995_RS00990	COG2111	Na H antiporter
CP3995_RS00990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP3995_RS01010	COG4152	abc transporter atp-binding protein
CP3995_RS01045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP3995_RS01065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP3995_RS01085	COG0494	nUDIX hydrolase
CP3995_RS01150	COG1205	dead DEAH box helicase
CP3995_RS01150	COG1111	helicase
CP3995_RS01160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP3995_RS01160	COG1754	DNA topoisomerase type I activity
CP3995_RS01165	COG1297	OPT oligopeptide transporter protein
CP3995_RS01175	COG0470	DNA polymerase III
CP3995_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
CP3995_RS01200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CP3995_RS01210	COG1088	dTDP-glucose 4,6-dehydratase activity
CP3995_RS01220	COG1505	serine-type exopeptidase activity
CP3995_RS01230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP3995_RS01235	COG1396	sequence-specific DNA binding
CP3995_RS01235	COG3800	Transcriptional regulator
CP3995_RS01245	COG1053	succinate dehydrogenase
CP3995_RS01250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP3995_RS01260	COG2733	membrane
CP3995_RS01270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CP3995_RS01290	COG1882	Formate acetyltransferase
CP3995_RS01310	COG0318	PFAM AMP-dependent synthetase and ligase
CP3995_RS01325	COG5002	protein histidine kinase activity
CP3995_RS01330	COG0745	RESPONSE REGULATOR receiver
CP3995_RS01350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP3995_RS01360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CP3995_RS01360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP3995_RS01390	COG1648	precorrin-2 dehydrogenase activity
CP3995_RS01390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP3995_RS01405	COG2217	Heavy metal translocating P-type atpase
CP3995_RS01415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP3995_RS01430	COG0406	alpha-ribazole phosphatase activity
CP3995_RS01440	COG0785	Cytochrome C biogenesis protein
CP3995_RS01450	COG0275	rRNA processing
CP3995_RS01465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS01470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP3995_RS01500	COG3069	C4-dicarboxylate transmembrane transporter activity
CP3995_RS01505	COG4948	Mandelate Racemase Muconate Lactonizing
CP3995_RS01520	COG0438	transferase activity, transferring glycosyl groups
CP3995_RS01520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP3995_RS01530	COG0039	L-malate dehydrogenase activity
CP3995_RS01535	COG0644	oxidoreductase
CP3995_RS01540	COG0142	geranyltranstransferase activity
CP3995_RS01565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP3995_RS01590	COG3579	cysteine-type endopeptidase activity
CP3995_RS01595	COG1902	pentaerythritol trinitrate reductase activity
CP3995_RS01615	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP3995_RS01625	COG1121	(ABC) transporter
CP3995_RS01630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP3995_RS01670	COG1131	(ABC) transporter
CP3995_RS01685	COG0701	Predicted permease
CP3995_RS01755	COG1302	Protein conserved in bacteria
CP3995_RS01850	COG0814	amino acid
CP3995_RS01855	COG1760	l-serine dehydratase
CP3995_RS01860	COG0252	asparaginase activity
CP3995_RS01865	COG0671	phosphoesterase, PA-phosphatase related
CP3995_RS01910	COG1175	transmembrane transport
CP3995_RS01915	COG3833	ABC-type maltose transport systems, permease component
CP3995_RS01935	COG3842	ATPase activity
CP3995_RS01940	COG0201	protein transport
CP3995_RS01995	COG0203	ribosomal protein L17
CP3995_RS02015	COG1404	Belongs to the peptidase S8 family
CP3995_RS02025	COG1674	ftsk spoiiie
CP3995_RS02085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP3995_RS02155	COG0516	GMP reductase activity
CP3995_RS02200	COG2011	ABC-type metal ion transport system permease component
CP3995_RS02210	COG1464	Belongs to the NlpA lipoprotein family
CP3995_RS02215	COG1464	Belongs to the NlpA lipoprotein family
CP3995_RS02235	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP3995_RS02240	COG1121	(ABC) transporter
CP3995_RS02250	COG1321	iron dependent repressor
CP3995_RS02250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP3995_RS02255	COG1321	iron dependent repressor
CP3995_RS02260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CP3995_RS02265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP3995_RS02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS02305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP3995_RS02320	COG2838	Isocitrate dehydrogenase
CP3995_RS02325	COG2814	Major facilitator Superfamily
CP3995_RS02330	COG0789	Transcriptional regulator
CP3995_RS02330	COG4978	Transcriptional regulator
CP3995_RS02345	COG0180	Tryptophanyl-tRNA synthetase
CP3995_RS02350	COG1295	ribonuclease BN
CP3995_RS02355	COG1686	Belongs to the peptidase S11 family
CP3995_RS02390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP3995_RS02395	COG1473	amidohydrolase
CP3995_RS02395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP3995_RS02410	COG2814	Major facilitator Superfamily
CP3995_RS02420	COG4770	biotin carboxylase activity
CP3995_RS02425	COG2897	thiosulfate sulfurtransferase activity
CP3995_RS02430	COG0189	ligase activity
CP3995_RS02435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP3995_RS02435	COG2755	lipolytic protein G-D-S-L family
CP3995_RS02445	COG0424	maF-like protein
CP3995_RS02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP3995_RS02455	COG1609	Transcriptional regulator
CP3995_RS02465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP3995_RS02470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP3995_RS02475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CP3995_RS02475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CP3995_RS02525	COG1316	TRANSCRIPTIONal
CP3995_RS02535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP3995_RS02565	COG1482	cell wall glycoprotein biosynthetic process
CP3995_RS02590	COG0745	RESPONSE REGULATOR receiver
CP3995_RS02595	COG5002	protein histidine kinase activity
CP3995_RS02610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP3995_RS02650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP3995_RS02655	COG2135	peptidase activity
CP3995_RS02660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CP3995_RS02695	COG0513	Belongs to the DEAD box helicase family
CP3995_RS02720	COG0210	DNA helicase
CP3995_RS02730	COG2816	NAD+ diphosphatase activity
CP3995_RS02755	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP3995_RS02870	COG0483	inositol monophosphate 1-phosphatase activity
CP3995_RS02875	COG0483	inositol monophosphate 1-phosphatase activity
CP3995_RS02890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CP3995_RS02895	COG2884	Cell division ATP-binding protein ftsE
CP3995_RS02900	COG2177	Part of the ABC transporter FtsEX involved in
CP3995_RS02910	COG0288	reversible hydration of carbon dioxide
CP3995_RS02960	COG1061	Type III restriction enzyme res subunit
CP3995_RS02975	COG1652	LysM domain
CP3995_RS03000	COG2252	PERMEase
CP3995_RS03005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP3995_RS03025	COG0372	Belongs to the citrate synthase family
CP3995_RS03030	COG0545	Peptidyl-prolyl cis-trans isomerase
CP3995_RS03045	COG0656	L-ascorbic acid biosynthetic process
CP3995_RS03050	COG1024	Enoyl-CoA hydratase
CP3995_RS03060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP3995_RS03070	COG3757	hydrolase, family 25
CP3995_RS03085	COG0534	Mate efflux family protein
CP3995_RS03090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP3995_RS03095	COG0019	diaminopimelate decarboxylase activity
CP3995_RS03110	COG4166	transmembrane transport
CP3995_RS03125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP3995_RS03145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CP3995_RS03160	COG1218	3'(2'),5'-bisphosphate nucleotidase
CP3995_RS03165	COG1201	RNA secondary structure unwinding
CP3995_RS03175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP3995_RS03225	COG1126	abc transporter atp-binding protein
CP3995_RS03230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP3995_RS03235	COG0765	amino acid transport
CP3995_RS03240	COG0765	amino acid transport
CP3995_RS03250	COG1309	transcriptional regulator
CP3995_RS03280	COG0254	rRNA binding
CP3995_RS03290	COG0745	RESPONSE REGULATOR receiver
CP3995_RS03295	COG2205	protein histidine kinase activity
CP3995_RS03300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP3995_RS03305	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP3995_RS03305	COG0315	cyclic pyranopterin monophosphate synthase activity
CP3995_RS03325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP3995_RS03345	COG2259	Doxx family
CP3995_RS03355	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CP3995_RS03360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP3995_RS03365	COG3949	Membrane
CP3995_RS03380	COG0084	hydrolase, TatD family'
CP3995_RS03385	COG3583	domain protein
CP3995_RS03400	COG0488	(ABC) transporter
CP3995_RS03415	COG2326	polyphosphate kinase activity
CP3995_RS03450	COG0596	Alpha beta hydrolase
CP3995_RS03455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CP3995_RS03465	COG0193	aminoacyl-tRNA hydrolase activity
CP3995_RS03470	COG2070	2-Nitropropane dioxygenase
CP3995_RS03490	COG1523	belongs to the glycosyl hydrolase 13 family
CP3995_RS03495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP3995_RS03500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP3995_RS03505	COG2132	Multicopper oxidase
CP3995_RS03520	COG1309	transcriptional regulator
CP3995_RS03530	COG0531	amino acid
CP3995_RS03535	COG3956	TIGRFAM MazG family protein
CP3995_RS03600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP3995_RS03670	COG0114	fumarate hydratase activity
CP3995_RS03675	COG1494	fructose-1,6-bisphosphatase
CP3995_RS03710	COG0012	GTP binding
CP3995_RS03725	COG2824	Alkylphosphonate utilization operon protein PhnA
CP3995_RS03730	COG1132	(ABC) transporter
CP3995_RS03745	COG2354	Protein conserved in bacteria
CP3995_RS03755	COG4721	ABC-type cobalt transport system, permease component
CP3995_RS03760	COG1122	ATPase activity
CP3995_RS03770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP3995_RS03780	COG4166	transmembrane transport
CP3995_RS03785	COG0601	transmembrane transport
CP3995_RS03790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP3995_RS03820	COG1217	gtp-binding protein TYPA
CP3995_RS03825	COG4166	transmembrane transport
CP3995_RS03860	COG1113	amino acid transport
CP3995_RS03870	COG1113	amino acid transport
CP3995_RS03880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP3995_RS03885	COG1611	Belongs to the LOG family
CP3995_RS03890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP3995_RS03895	COG0463	Glycosyl transferase, family 2
CP3995_RS03915	COG3527	Alpha-acetolactate decarboxylase
CP3995_RS03920	COG0297	glycogen (starch) synthase activity
CP3995_RS03930	COG4122	O-methyltransferase activity
CP3995_RS03960	COG2239	Acts as a magnesium transporter
CP3995_RS03970	COG0567	Dehydrogenase, E1 component
CP3995_RS03970	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP3995_RS03975	COG1132	(ABC) transporter
CP3995_RS03985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP3995_RS03990	COG2272	Belongs to the type-B carboxylesterase lipase family
CP3995_RS04005	COG2017	converts alpha-aldose to the beta-anomer
CP3995_RS04025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CP3995_RS04055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP3995_RS04060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP3995_RS04085	COG1846	Transcriptional regulator
CP3995_RS04100	COG1349	DNA-binding transcription factor activity
CP3995_RS04115	COG1556	Lactate utilization protein
CP3995_RS04120	COG1139	Iron-sulfur cluster binding protein
CP3995_RS04125	COG0247	lactate metabolic process
CP3995_RS04130	COG1620	l-lactate permease
CP3995_RS04140	COG0019	diaminopimelate decarboxylase activity
CP3995_RS04145	COG0460	homoserine dehydrogenase
CP3995_RS04195	COG0356	it plays a direct role in the translocation of protons across the membrane
CP3995_RS04200	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP3995_RS04205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP3995_RS04245	COG0346	lactoylglutathione lyase activity
CP3995_RS04270	COG1119	ATPase activity
CP3995_RS04290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP3995_RS04355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS04360	COG1120	ATPase activity
CP3995_RS04370	COG0205	6-phosphofructokinase activity
CP3995_RS04380	COG0667	Aldo Keto reductase
CP3995_RS04390	COG0583	DNA-binding transcription factor activity
CP3995_RS04415	COG0668	transmembrane transport
CP3995_RS04455	COG0473	3-isopropylmalate dehydrogenase activity
CP3995_RS04475	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP3995_RS04505	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CP3995_RS04540	COG0494	nUDIX hydrolase
CP3995_RS04540	COG0406	alpha-ribazole phosphatase activity
CP3995_RS04560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CP3995_RS04565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP3995_RS04570	COG1461	Dihydroxyacetone kinase
CP3995_RS04580	COG0511	ligase activity, forming carbon-carbon bonds
CP3995_RS04585	COG0742	ribosomal rna small subunit methyltransferase
CP3995_RS04610	COG0765	amino acid transport
CP3995_RS04635	COG2226	methyltransferase
CP3995_RS04640	COG0539	negative regulation of cytoplasmic translation
CP3995_RS04650	COG0237	dephospho-CoA kinase activity
CP3995_RS04670	COG3973	AAA domain
CP3995_RS04680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP3995_RS04695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP3995_RS04710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP3995_RS04725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP3995_RS04740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP3995_RS04745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP3995_RS04765	COG0165	Argininosuccinate lyase
CP3995_RS04770	COG2835	tetraacyldisaccharide 4'-kinase activity
CP3995_RS04800	COG0647	UMP catabolic process
CP3995_RS04830	COG0494	nUDIX hydrolase
CP3995_RS04835	COG4974	Belongs to the 'phage' integrase family
CP3995_RS04855	COG3104	oligopeptide transport
CP3995_RS04860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP3995_RS04870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP3995_RS04885	COG1160	GTP binding
CP3995_RS04890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CP3995_RS04895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP3995_RS04900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CP3995_RS04905	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP3995_RS04910	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CP3995_RS04915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS04920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS04925	COG1120	ATPase activity
CP3995_RS04930	COG4264	IucA IucC family
CP3995_RS04960	COG0653	protein targeting
CP3995_RS05000	COG1253	flavin adenine dinucleotide binding
CP3995_RS05005	COG0513	Belongs to the DEAD box helicase family
CP3995_RS05010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CP3995_RS05020	COG0598	Magnesium transport protein CorA
CP3995_RS05040	COG0477	Major facilitator Superfamily
CP3995_RS05060	COG0463	Glycosyl transferase, family 2
CP3995_RS05110	COG0300	oxidoreductase activity
CP3995_RS05125	COG0805	protein transport
CP3995_RS05135	COG2378	regulation of single-species biofilm formation
CP3995_RS05155	COG4122	O-methyltransferase activity
CP3995_RS05170	COG1362	aminopeptidase activity
CP3995_RS05190	COG1027	Aspartate ammonia-lyase
CP3995_RS05195	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CP3995_RS05215	COG0646	methionine synthase
CP3995_RS05215	COG1410	methionine synthase
CP3995_RS05235	COG0667	Aldo Keto reductase
CP3995_RS05245	COG0167	dihydroorotate dehydrogenase activity
CP3995_RS05270	COG1461	Dihydroxyacetone kinase
CP3995_RS05275	COG2376	Dihydroxyacetone kinase
CP3995_RS05285	COG0488	(ABC) transporter
CP3995_RS05350	COG0791	NLP P60 protein
CP3995_RS05350	COG3883	PFAM NLP P60 protein
CP3995_RS05380	COG2848	UPF0210 protein
CP3995_RS05405	COG2151	metal-sulfur cluster biosynthetic enzyme
CP3995_RS05410	COG0822	iron-sulfur transferase activity
CP3995_RS05420	COG0396	ATPase activity
CP3995_RS05465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CP3995_RS05470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP3995_RS05490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP3995_RS05510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP3995_RS05520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP3995_RS05530	COG0322	excinuclease ABC activity
CP3995_RS05560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP3995_RS05575	COG0242	peptide deformylase activity
CP3995_RS05615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP3995_RS05625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP3995_RS05640	COG1090	epimerase
CP3995_RS05665	COG0006	proline dipeptidase activity
CP3995_RS05670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP3995_RS05675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP3995_RS05680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP3995_RS05685	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP3995_RS05705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP3995_RS05760	COG1760	l-serine dehydratase
CP3995_RS05785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP3995_RS05790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CP3995_RS05805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP3995_RS05820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP3995_RS05825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP3995_RS05855	COG1946	Acyl-CoA thioesterase
CP3995_RS05870	COG0156	8-amino-7-oxononanoate synthase activity
CP3995_RS05885	COG1560	Kdo2-lipid A biosynthetic process
CP3995_RS05890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP3995_RS05905	COG2837	iron assimilation
CP3995_RS05955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP3995_RS05960	COG3253	May function as heme-dependent peroxidase
CP3995_RS06045	COG2890	protein-(glutamine-N5) methyltransferase activity
CP3995_RS06085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP3995_RS06090	COG0450	alkyl hydroperoxide reductase
CP3995_RS06105	COG1643	Atp-dependent helicase
CP3995_RS06125	COG1349	DNA-binding transcription factor activity
CP3995_RS06130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP3995_RS06135	COG1349	DNA-binding transcription factor activity
CP3995_RS06140	COG1105	Belongs to the carbohydrate kinase PfkB family
CP3995_RS06145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CP3995_RS06145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP3995_RS06145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP3995_RS06150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP3995_RS06155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP3995_RS06165	COG2233	PERMEase
CP3995_RS06170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP3995_RS06185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP3995_RS06200	COG1196	nuclear chromosome segregation
CP3995_RS06220	COG2137	regulation of response to DNA damage stimulus
CP3995_RS06225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CP3995_RS06235	COG1268	BioY protein
CP3995_RS06240	COG1122	ATPase activity
CP3995_RS06250	COG1842	Phage shock protein A
CP3995_RS06255	COG1396	sequence-specific DNA binding
CP3995_RS06280	COG1674	ftsk spoiiie
CP3995_RS06290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP3995_RS06330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP3995_RS06340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP3995_RS06345	COG0534	Mate efflux family protein
CP3995_RS06390	COG3022	response to hydroperoxide
CP3995_RS06395	COG1648	precorrin-2 dehydrogenase activity
CP3995_RS06395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP3995_RS06400	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CP3995_RS06405	COG0523	cobalamin synthesis protein
CP3995_RS06410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP3995_RS06410	COG2169	Transcriptional regulator
CP3995_RS06475	COG0750	zinc metalloprotease
CP3995_RS06530	COG4974	Belongs to the 'phage' integrase family
CP3995_RS06560	COG0681	Belongs to the peptidase S26 family
CP3995_RS06575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP3995_RS06575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP3995_RS06575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP3995_RS06585	COG0336	Belongs to the RNA methyltransferase TrmD family
CP3995_RS06590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP3995_RS06610	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP3995_RS06640	COG1115	amino acid carrier protein
CP3995_RS06645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP3995_RS06670	COG0686	Belongs to the AlaDH PNT family
CP3995_RS06675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CP3995_RS06680	COG1929	Belongs to the glycerate kinase type-1 family
CP3995_RS06700	COG0058	SHG alpha-glucan phosphorylase activity
CP3995_RS06710	COG0469	pyruvate kinase activity
CP3995_RS06720	COG0134	indole-3-glycerol-phosphate synthase activity
CP3995_RS06740	COG0483	inositol monophosphate 1-phosphatase activity
CP3995_RS06805	COG2176	DNA-directed DNA polymerase activity
CP3995_RS06830	COG1739	Uncharacterized protein family UPF0029
CP3995_RS06835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP3995_RS06860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP3995_RS06875	COG0252	asparaginase activity
CP3995_RS06895	COG3599	regulation of cell shape
CP3995_RS06905	COG1799	cell septum assembly
CP3995_RS06910	COG1496	oxidoreductase activity
CP3995_RS06915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CP3995_RS06925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP3995_RS06955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP3995_RS06960	COG0768	penicillin binding
CP3995_RS07000	COG0142	geranyltranstransferase activity
CP3995_RS07015	COG2815	serine threonine protein kinase
CP3995_RS07015	COG0515	serine threonine protein kinase
CP3995_RS07020	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP3995_RS07040	COG1940	carbohydrate kinase activity
CP3995_RS07045	COG0438	transferase activity, transferring glycosyl groups
CP3995_RS07055	COG0791	NLP P60 protein
CP3995_RS07105	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CP3995_RS07110	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP3995_RS07120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP3995_RS07135	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP3995_RS07140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP3995_RS07140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP3995_RS07145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP3995_RS07150	COG0509	glycine decarboxylation via glycine cleavage system
CP3995_RS07180	COG0174	glutamine synthetase
CP3995_RS07330	COG2056	Na+-H+ antiporter family
CP3995_RS07340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP3995_RS07365	COG0174	glutamine synthetase
CP3995_RS07390	COG0557	exoribonuclease II activity
CP3995_RS07405	COG3323	Protein of unknown function (DUF1653)
CP3995_RS07405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CP3995_RS07445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP3995_RS07450	COG0596	Alpha beta hydrolase
CP3995_RS07475	COG2860	membrane
CP3995_RS07545	COG0423	glycine-tRNA ligase activity
CP3995_RS07570	COG1381	Involved in DNA repair and RecF pathway recombination
CP3995_RS07625	COG1022	Amp-dependent synthetase and ligase
CP3995_RS07680	COG1114	Component of the transport system for branched-chain amino acids
CP3995_RS07685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP3995_RS07695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP3995_RS07710	COG0747	negative chemotaxis
CP3995_RS07715	COG0601	transmembrane transport
CP3995_RS07720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP3995_RS07725	COG4172	Belongs to the ABC transporter superfamily
CP3995_RS07735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CP3995_RS07740	COG2391	methyltransferase activity
CP3995_RS07745	COG0601	transmembrane transport
CP3995_RS07760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP3995_RS07765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP3995_RS07790	COG1280	lysine exporter protein (LysE YggA)
CP3995_RS07815	COG1307	EDD domain protein, DegV family
CP3995_RS07820	COG0406	alpha-ribazole phosphatase activity
CP3995_RS07830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP3995_RS07845	COG2832	Protein of unknown function (DUF454)
CP3995_RS07850	COG2985	domain, Protein
CP3995_RS07850	COG0569	domain protein
CP3995_RS07875	COG1530	ribonuclease E activity
CP3995_RS07890	COG2423	ornithine cyclodeaminase activity
CP3995_RS07900	COG0285	dihydrofolate synthase activity
CP3995_RS07940	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP3995_RS07975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP3995_RS07995	COG0668	transmembrane transport
CP3995_RS08070	COG1131	(ABC) transporter
CP3995_RS08075	COG3336	cytochrome c oxidase
CP3995_RS08080	COG1966	Carbon starvation protein
CP3995_RS08100	COG0604	alcohol dehydrogenase
CP3995_RS08125	COG1376	ErfK ybiS ycfS ynhG family protein
CP3995_RS08135	COG2130	NADP-dependent
CP3995_RS08140	COG1335	isochorismatase
CP3995_RS08185	COG2197	response regulator
CP3995_RS08235	COG1234	tRNA 3'-trailer cleavage
CP3995_RS08260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CP3995_RS08305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP3995_RS08315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP3995_RS08335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP3995_RS08400	COG0033	Phosphoglucomutase
CP3995_RS08415	COG0577	efflux transmembrane transporter activity
CP3995_RS08415	COG1136	(ABC) transporter
CP3995_RS08420	COG0577	efflux transmembrane transporter activity
CP3995_RS08420	COG1136	(ABC) transporter
CP3995_RS08450	COG2197	response regulator
CP3995_RS08460	COG1045	serine acetyltransferase
CP3995_RS08480	COG0371	Dehydrogenase
CP3995_RS08500	COG1271	oxidase subunit
CP3995_RS08505	COG1294	oxidase, subunit
CP3995_RS08510	COG4988	ABC transporter
CP3995_RS08515	COG1132	(ABC) transporter
CP3995_RS08540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP3995_RS08570	COG1597	lipid kinase activity
CP3995_RS08585	COG0354	folic acid binding
CP3995_RS08610	COG1780	Probably involved in ribonucleotide reductase function
CP3995_RS08615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP3995_RS08625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP3995_RS08630	COG0047	phosphoribosylformylglycinamidine synthase activity
CP3995_RS08635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP3995_RS08640	COG0386	Belongs to the glutathione peroxidase family
CP3995_RS08660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP3995_RS08665	COG0569	domain protein
CP3995_RS08670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CP3995_RS08675	COG0151	Belongs to the GarS family
CP3995_RS08680	COG0537	adenosine 5'-monophosphoramidase activity
CP3995_RS08690	COG2205	protein histidine kinase activity
CP3995_RS08695	COG0745	RESPONSE REGULATOR receiver
CP3995_RS08725	COG0028	Belongs to the TPP enzyme family
CP3995_RS08765	COG1609	Transcriptional regulator
CP3995_RS08775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP3995_RS08795	COG1329	Transcriptional regulator
CP3995_RS08800	COG2847	Copper chaperone PCu(A)C
CP3995_RS08815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CP3995_RS08825	COG0288	reversible hydration of carbon dioxide
CP3995_RS08840	COG0542	response to heat
CP3995_RS08850	COG0477	Major facilitator Superfamily
CP3995_RS08855	COG1957	nucleoside hydrolase
CP3995_RS08870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP3995_RS08885	COG1301	dicarboxylic acid transport
CP3995_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
CP3995_RS08895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP3995_RS08900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CP3995_RS08905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP3995_RS08935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP3995_RS08940	COG0302	gtp cyclohydrolase
CP3995_RS08945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP3995_RS08950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CP3995_RS08960	COG2027	D-alanyl-D-alanine carboxypeptidase
CP3995_RS08965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP3995_RS08970	COG0425	Belongs to the sulfur carrier protein TusA family
CP3995_RS08970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP3995_RS08975	COG1301	dicarboxylic acid transport
CP3995_RS08990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP3995_RS08995	COG2326	polyphosphate kinase activity
CP3995_RS09035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP3995_RS09035	COG2111	Na H antiporter
CP3995_RS09040	COG1006	Multisubunit Na H antiporter MnhC subunit
CP3995_RS09045	COG0651	ATP synthesis coupled electron transport
CP3995_RS09065	COG1051	belongs to the nudix hydrolase family
CP3995_RS09085	COG0242	peptide deformylase activity
CP3995_RS09090	COG0456	acetyltransferase
CP3995_RS09100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP3995_RS09125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP3995_RS09140	COG0280	phosphate acetyltransferase
CP3995_RS09160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CP3995_RS09165	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CP3995_RS09195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP3995_RS09200	COG1333	cytochrome c biogenesis protein
CP3995_RS09210	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CP3995_RS09215	COG3005	denitrification pathway
CP3995_RS09230	COG4129	membrane
CP3995_RS09280	COG0191	fructose-bisphosphate aldolase activity
CP3995_RS09295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP3995_RS09310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP3995_RS09350	COG1131	(ABC) transporter
CP3995_RS09380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP3995_RS09400	COG0577	efflux transmembrane transporter activity
CP3995_RS09400	COG1136	(ABC) transporter
CP3995_RS09405	COG1136	(ABC) transporter
CP3995_RS09410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP3995_RS09450	COG0789	Transcriptional regulator
CP3995_RS09465	COG0443	Heat shock 70 kDa protein
CP3995_RS09500	COG0601	transmembrane transport
CP3995_RS09520	COG0247	lactate metabolic process
CP3995_RS09520	COG2181	nitrate reductase activity
CP3995_RS09535	COG1120	ATPase activity
CP3995_RS09540	COG4139	cobalamin transport
CP3995_RS09550	COG0829	nickel cation binding
CP3995_RS09555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP3995_RS09560	COG0830	nickel cation binding
CP3995_RS09565	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CP3995_RS09570	COG0804	urea catabolic process
CP3995_RS09575	COG0832	Belongs to the urease beta subunit family
CP3995_RS09580	COG0831	urea catabolic process
CP3995_RS09600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP3995_RS09600	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP3995_RS09620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP3995_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
CP3995_RS09645	COG1472	Belongs to the glycosyl hydrolase 3 family
CP3995_RS09655	COG4981	capsule polysaccharide biosynthetic process
CP3995_RS09660	COG2755	lipolytic protein G-D-S-L family
CP3995_RS09660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP3995_RS09670	COG0438	transferase activity, transferring glycosyl groups
CP3995_RS09675	COG0500	methyltransferase
CP3995_RS09720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP3995_RS09725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP3995_RS09725	COG3321	synthase
CP3995_RS09725	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CP3995_RS09730	COG0318	PFAM AMP-dependent synthetase and ligase
CP3995_RS09735	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CP3995_RS09745	COG5479	isomerase activity
CP3995_RS09745	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CP3995_RS09760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CP3995_RS09765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP3995_RS09770	COG0671	phosphoesterase, PA-phosphatase related
CP3995_RS09775	COG1216	Glycosyl transferase, family 2
CP3995_RS09785	COG0671	phosphoesterase, PA-phosphatase related
CP3995_RS09795	COG0584	glycerophosphoryl diester phosphodiesterase
CP3995_RS09800	COG2271	Major facilitator Superfamily
CP3995_RS09815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP3995_RS09820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP3995_RS09830	COG0561	phosphatase activity
CP3995_RS09845	COG2188	Transcriptional regulator
CP3995_RS09865	COG0077	Prephenate dehydratase
CP3995_RS09870	COG0154	amidase activity
CP3995_RS09880	COG1316	TRANSCRIPTIONal
CP3995_RS09910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CP3995_RS09940	COG0431	NADPH-dependent FMN reductase
CP3995_RS09945	COG2814	Major facilitator Superfamily
CP3995_RS09970	COG5650	phosphatidylinositol metabolic process
CP3995_RS09990	COG2197	response regulator
CP3995_RS10010	COG3764	Sortase (surface protein transpeptidase)
CP3995_RS10015	COG0706	membrane insertase activity
CP3995_RS10040	COG0564	pseudouridine synthase activity
CP3995_RS10065	COG1131	(ABC) transporter
CP3995_RS10080	COG1842	Phage shock protein A
CP3995_RS10085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP3995_RS10100	COG0477	Major facilitator Superfamily
CP3995_RS10105	COG0305	Participates in initiation and elongation during chromosome replication
CP3995_RS10110	COG3387	PFAM Glycoside hydrolase 15-related
CP3995_RS10120	COG0629	single-stranded DNA binding
CP3995_RS10140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP3995_RS10160	COG0300	oxidoreductase activity
CP3995_RS10175	COG0586	Pfam SNARE associated Golgi protein
CP3995_RS10180	COG0783	Belongs to the Dps family
CP3995_RS10185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP3995_RS10190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CP3995_RS10190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CP3995_RS10200	COG1511	domain protein
CP3995_RS10210	COG1136	(ABC) transporter
CP3995_RS10210	COG0577	efflux transmembrane transporter activity
CP3995_RS10230	COG4585	Histidine kinase
CP3995_RS10235	COG2197	response regulator
CP3995_RS10250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CP3995_RS10265	COG2186	Transcriptional regulator
CP3995_RS10270	COG0747	negative chemotaxis
CP3995_RS10275	COG0601	transmembrane transport
CP3995_RS10280	COG0444	Belongs to the ABC transporter superfamily
CP3995_RS10285	COG4608	Belongs to the ABC transporter superfamily
CP3995_RS10290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP3995_RS10330	COG3422	double-strand break repair
CP3995_RS10345	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CP3995_RS10365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP3995_RS10370	COG0512	Glutamine amidotransferase of anthranilate synthase
CP3995_RS10380	COG0135	phosphoribosylanthranilate isomerase activity
CP3995_RS10380	COG0134	indole-3-glycerol-phosphate synthase activity
CP3995_RS10415	COG1687	branched-chain amino acid
CP3995_RS10420	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CP3995_RS10425	COG1678	Uncharacterized ACR, COG1678
CP3995_RS10430	COG0617	tRNA 3'-terminal CCA addition
CP3995_RS10465	COG3409	Peptidoglycan-binding domain 1 protein
CP3995_RS10465	COG0860	N-Acetylmuramoyl-L-alanine amidase
CP3995_RS10480	COG1192	Involved in chromosome partitioning
CP3995_RS10495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CP3995_RS10505	COG0230	Belongs to the bacterial ribosomal protein bL34 family