locus-tag	class	description
CpE19_RS00010	COG0592	DNA-directed DNA polymerase activity
CpE19_RS00025	COG0187	DNA topoisomerase II activity
CpE19_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CpE19_RS00130	COG1518	maintenance of DNA repeat elements
CpE19_RS00175	COG1120	ATPase activity
CpE19_RS00180	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE19_RS00185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE19_RS00190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpE19_RS00200	COG2815	serine threonine protein kinase
CpE19_RS00200	COG0515	serine threonine protein kinase
CpE19_RS00205	COG0515	serine threonine protein kinase
CpE19_RS00210	COG0768	penicillin binding
CpE19_RS00215	COG0772	Belongs to the SEDS family
CpE19_RS00230	COG1716	ATPase activity
CpE19_RS00230	COG1716	ATPase activity
CpE19_RS00275	COG2239	Acts as a magnesium transporter
CpE19_RS00280	COG0366	Alpha amylase catalytic
CpE19_RS00335	COG1125	glycine betaine transport
CpE19_RS00335	COG0517	IMP dehydrogenase activity
CpE19_RS00345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpE19_RS00365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CpE19_RS00375	COG3409	Peptidoglycan-binding domain 1 protein
CpE19_RS00375	COG3757	hydrolase, family 25
CpE19_RS00400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CpE19_RS00430	COG1846	Transcriptional regulator
CpE19_RS00445	COG3180	Ammonia monooxygenase
CpE19_RS00455	COG0730	response to heat
CpE19_RS00470	COG1643	Atp-dependent helicase
CpE19_RS00480	COG0519	Catalyzes the synthesis of GMP from XMP
CpE19_RS00490	COG0393	Putative heavy-metal-binding
CpE19_RS00495	COG2501	S4 domain
CpE19_RS00515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CpE19_RS00520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CpE19_RS00530	COG3590	peptidase
CpE19_RS00560	COG1028	Short-chain dehydrogenase reductase Sdr
CpE19_RS00565	COG0277	FAD linked oxidase domain protein
CpE19_RS00595	COG1216	Glycosyl transferase, family 2
CpE19_RS00600	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpE19_RS00605	COG1121	(ABC) transporter
CpE19_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpE19_RS00615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpE19_RS00620	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpE19_RS00645	COG0604	alcohol dehydrogenase
CpE19_RS00705	COG0471	metal ion transport
CpE19_RS00715	COG1263	PTS System
CpE19_RS00715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpE19_RS00720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpE19_RS00720	COG2190	(PTS) system
CpE19_RS00720	COG1263	PTS System
CpE19_RS00745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpE19_RS00755	COG0287	Prephenate dehydrogenase
CpE19_RS00775	COG2409	Drug exporters of the RND superfamily
CpE19_RS00780	COG0343	queuine tRNA-ribosyltransferase activity
CpE19_RS00790	COG2610	gluconate transmembrane transporter activity
CpE19_RS00795	COG3265	gluconokinase activity
CpE19_RS00800	COG1063	alcohol dehydrogenase
CpE19_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
CpE19_RS00815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpE19_RS00840	COG2610	gluconate transmembrane transporter activity
CpE19_RS00845	COG2084	Dehydrogenase
CpE19_RS00855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpE19_RS00860	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpE19_RS00865	COG3442	glutamine amidotransferase
CpE19_RS00870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CpE19_RS00880	COG0778	Nitroreductase
CpE19_RS00885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CpE19_RS00890	COG2390	Transcriptional regulator
CpE19_RS00895	COG0813	purine-nucleoside phosphorylase activity
CpE19_RS00910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpE19_RS00930	COG0697	spore germination
CpE19_RS00935	COG0527	aspartate kinase activity
CpE19_RS00990	COG1840	ABC-type Fe3 transport system, periplasmic component
CpE19_RS00995	COG2271	Major facilitator Superfamily
CpE19_RS01025	COG0651	ATP synthesis coupled electron transport
CpE19_RS01035	COG2111	Na H antiporter
CpE19_RS01035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpE19_RS01065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpE19_RS01085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CpE19_RS01105	COG0494	nUDIX hydrolase
CpE19_RS01170	COG1111	helicase
CpE19_RS01170	COG1205	dead DEAH box helicase
CpE19_RS01180	COG1754	DNA topoisomerase type I activity
CpE19_RS01180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CpE19_RS01185	COG1297	OPT oligopeptide transporter protein
CpE19_RS01195	COG0470	DNA polymerase III
CpE19_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
CpE19_RS01220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CpE19_RS01230	COG1088	dTDP-glucose 4,6-dehydratase activity
CpE19_RS01240	COG1505	serine-type exopeptidase activity
CpE19_RS01250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CpE19_RS01255	COG1396	sequence-specific DNA binding
CpE19_RS01255	COG3800	Transcriptional regulator
CpE19_RS01265	COG1053	succinate dehydrogenase
CpE19_RS01270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CpE19_RS01280	COG2733	membrane
CpE19_RS01290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CpE19_RS01310	COG1882	Formate acetyltransferase
CpE19_RS01330	COG0318	PFAM AMP-dependent synthetase and ligase
CpE19_RS01345	COG5002	protein histidine kinase activity
CpE19_RS01350	COG0745	RESPONSE REGULATOR receiver
CpE19_RS01360	COG0248	Ppx GppA phosphatase
CpE19_RS01385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CpE19_RS01385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CpE19_RS01415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpE19_RS01415	COG1648	precorrin-2 dehydrogenase activity
CpE19_RS01430	COG2217	Heavy metal translocating P-type atpase
CpE19_RS01440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CpE19_RS01455	COG0406	alpha-ribazole phosphatase activity
CpE19_RS01465	COG0785	Cytochrome C biogenesis protein
CpE19_RS01475	COG0275	rRNA processing
CpE19_RS01490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE19_RS01495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpE19_RS01525	COG3069	C4-dicarboxylate transmembrane transporter activity
CpE19_RS01530	COG4948	Mandelate Racemase Muconate Lactonizing
CpE19_RS01545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CpE19_RS01545	COG0438	transferase activity, transferring glycosyl groups
CpE19_RS01555	COG0039	L-malate dehydrogenase activity
CpE19_RS01560	COG0644	oxidoreductase
CpE19_RS01565	COG0142	geranyltranstransferase activity
CpE19_RS01590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpE19_RS01615	COG3579	cysteine-type endopeptidase activity
CpE19_RS01620	COG1902	pentaerythritol trinitrate reductase activity
CpE19_RS01640	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpE19_RS01650	COG1121	(ABC) transporter
CpE19_RS01655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpE19_RS01685	COG2197	response regulator
CpE19_RS01690	COG1131	(ABC) transporter
CpE19_RS01705	COG0701	Predicted permease
CpE19_RS01775	COG1302	Protein conserved in bacteria
CpE19_RS01870	COG0814	amino acid
CpE19_RS01875	COG1760	l-serine dehydratase
CpE19_RS01880	COG0252	asparaginase activity
CpE19_RS01920	COG1140	nitrate reductase beta subunit
CpE19_RS01945	COG0746	molybdenum cofactor guanylyltransferase activity
CpE19_RS01950	COG0315	cyclic pyranopterin monophosphate synthase activity
CpE19_RS01960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CpE19_RS02010	COG1175	transmembrane transport
CpE19_RS02015	COG3833	ABC-type maltose transport systems, permease component
CpE19_RS02035	COG3842	ATPase activity
CpE19_RS02040	COG0201	protein transport
CpE19_RS02090	COG0203	ribosomal protein L17
CpE19_RS02110	COG1404	Belongs to the peptidase S8 family
CpE19_RS02120	COG1674	ftsk spoiiie
CpE19_RS02175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CpE19_RS02240	COG0516	GMP reductase activity
CpE19_RS02285	COG2011	ABC-type metal ion transport system permease component
CpE19_RS02295	COG1464	Belongs to the NlpA lipoprotein family
CpE19_RS02305	COG1464	Belongs to the NlpA lipoprotein family
CpE19_RS02320	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpE19_RS02325	COG1121	(ABC) transporter
CpE19_RS02335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpE19_RS02335	COG1321	iron dependent repressor
CpE19_RS02340	COG1321	iron dependent repressor
CpE19_RS02345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CpE19_RS02350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CpE19_RS02385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE19_RS02390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CpE19_RS02400	COG2873	o-acetylhomoserine
CpE19_RS02405	COG2838	Isocitrate dehydrogenase
CpE19_RS02410	COG2814	Major facilitator Superfamily
CpE19_RS02430	COG0180	Tryptophanyl-tRNA synthetase
CpE19_RS02435	COG1295	ribonuclease BN
CpE19_RS02440	COG1686	Belongs to the peptidase S11 family
CpE19_RS02475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpE19_RS02480	COG1473	amidohydrolase
CpE19_RS02480	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CpE19_RS02495	COG2814	Major facilitator Superfamily
CpE19_RS02505	COG4770	biotin carboxylase activity
CpE19_RS02510	COG2897	thiosulfate sulfurtransferase activity
CpE19_RS02515	COG0189	ligase activity
CpE19_RS02520	COG2755	lipolytic protein G-D-S-L family
CpE19_RS02520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpE19_RS02530	COG0424	maF-like protein
CpE19_RS02535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CpE19_RS02540	COG1609	Transcriptional regulator
CpE19_RS02550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpE19_RS02555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpE19_RS02560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CpE19_RS02560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CpE19_RS02610	COG1316	TRANSCRIPTIONal
CpE19_RS02620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CpE19_RS02650	COG1482	cell wall glycoprotein biosynthetic process
CpE19_RS02675	COG0745	RESPONSE REGULATOR receiver
CpE19_RS02680	COG5002	protein histidine kinase activity
CpE19_RS02695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CpE19_RS02735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CpE19_RS02740	COG2135	peptidase activity
CpE19_RS02745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CpE19_RS02780	COG0513	Belongs to the DEAD box helicase family
CpE19_RS02815	COG2816	NAD+ diphosphatase activity
CpE19_RS02840	COG3480	Lon protease (S16) C-terminal proteolytic domain
CpE19_RS02945	COG0483	inositol monophosphate 1-phosphatase activity
CpE19_RS02950	COG0483	inositol monophosphate 1-phosphatase activity
CpE19_RS02965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CpE19_RS02970	COG2884	Cell division ATP-binding protein ftsE
CpE19_RS02975	COG2177	Part of the ABC transporter FtsEX involved in
CpE19_RS03000	COG0288	reversible hydration of carbon dioxide
CpE19_RS03060	COG1061	Type III restriction enzyme res subunit
CpE19_RS03075	COG1652	LysM domain
CpE19_RS03100	COG2252	PERMEase
CpE19_RS03105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpE19_RS03125	COG0372	Belongs to the citrate synthase family
CpE19_RS03130	COG0545	Peptidyl-prolyl cis-trans isomerase
CpE19_RS03145	COG0656	L-ascorbic acid biosynthetic process
CpE19_RS03150	COG1024	Enoyl-CoA hydratase
CpE19_RS03160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpE19_RS03170	COG3757	hydrolase, family 25
CpE19_RS03185	COG0534	Mate efflux family protein
CpE19_RS03190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CpE19_RS03195	COG0019	diaminopimelate decarboxylase activity
CpE19_RS03210	COG4166	transmembrane transport
CpE19_RS03215	COG0601	transmembrane transport
CpE19_RS03225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpE19_RS03245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CpE19_RS03260	COG1218	3'(2'),5'-bisphosphate nucleotidase
CpE19_RS03265	COG1201	RNA secondary structure unwinding
CpE19_RS03275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpE19_RS03325	COG1126	abc transporter atp-binding protein
CpE19_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpE19_RS03335	COG0765	amino acid transport
CpE19_RS03340	COG0765	amino acid transport
CpE19_RS03350	COG1309	transcriptional regulator
CpE19_RS03380	COG0254	rRNA binding
CpE19_RS03390	COG0745	RESPONSE REGULATOR receiver
CpE19_RS03395	COG2205	protein histidine kinase activity
CpE19_RS03400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CpE19_RS03405	COG0315	cyclic pyranopterin monophosphate synthase activity
CpE19_RS03405	COG0521	Mo-molybdopterin cofactor biosynthetic process
CpE19_RS03430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CpE19_RS03450	COG2259	Doxx family
CpE19_RS03475	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CpE19_RS03480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpE19_RS03485	COG3949	Membrane
CpE19_RS03500	COG0084	hydrolase, TatD family'
CpE19_RS03505	COG3583	domain protein
CpE19_RS03520	COG0488	(ABC) transporter
CpE19_RS03535	COG2326	polyphosphate kinase activity
CpE19_RS03545	COG0561	phosphatase activity
CpE19_RS03570	COG0596	Alpha beta hydrolase
CpE19_RS03575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CpE19_RS03585	COG0193	aminoacyl-tRNA hydrolase activity
CpE19_RS03590	COG2070	2-Nitropropane dioxygenase
CpE19_RS03610	COG1523	belongs to the glycosyl hydrolase 13 family
CpE19_RS03615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CpE19_RS03620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CpE19_RS03625	COG2132	Multicopper oxidase
CpE19_RS03640	COG1309	transcriptional regulator
CpE19_RS03650	COG0531	amino acid
CpE19_RS03655	COG3956	TIGRFAM MazG family protein
CpE19_RS03720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CpE19_RS03790	COG0114	fumarate hydratase activity
CpE19_RS03795	COG1494	fructose-1,6-bisphosphatase
CpE19_RS03820	COG2801	Transposase and inactivated derivatives
CpE19_RS03840	COG0012	GTP binding
CpE19_RS03850	COG2824	Alkylphosphonate utilization operon protein PhnA
CpE19_RS03855	COG1132	(ABC) transporter
CpE19_RS03860	COG1132	(ABC) transporter
CpE19_RS03865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CpE19_RS03870	COG2354	Protein conserved in bacteria
CpE19_RS03880	COG4721	ABC-type cobalt transport system, permease component
CpE19_RS03885	COG1122	ATPase activity
CpE19_RS03895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CpE19_RS03905	COG4166	transmembrane transport
CpE19_RS03910	COG0601	transmembrane transport
CpE19_RS03915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpE19_RS03945	COG1217	gtp-binding protein TYPA
CpE19_RS03950	COG4166	transmembrane transport
CpE19_RS03985	COG1113	amino acid transport
CpE19_RS03995	COG1113	amino acid transport
CpE19_RS04005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpE19_RS04010	COG1611	Belongs to the LOG family
CpE19_RS04015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpE19_RS04020	COG0463	Glycosyl transferase, family 2
CpE19_RS04040	COG3527	Alpha-acetolactate decarboxylase
CpE19_RS04045	COG0297	glycogen (starch) synthase activity
CpE19_RS04055	COG4122	O-methyltransferase activity
CpE19_RS04085	COG2239	Acts as a magnesium transporter
CpE19_RS04095	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpE19_RS04095	COG0567	Dehydrogenase, E1 component
CpE19_RS04100	COG1132	(ABC) transporter
CpE19_RS04110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CpE19_RS04115	COG2272	Belongs to the type-B carboxylesterase lipase family
CpE19_RS04130	COG2017	converts alpha-aldose to the beta-anomer
CpE19_RS04150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CpE19_RS04180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpE19_RS04185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CpE19_RS04210	COG1846	Transcriptional regulator
CpE19_RS04240	COG1556	Lactate utilization protein
CpE19_RS04245	COG1139	Iron-sulfur cluster binding protein
CpE19_RS04250	COG0247	lactate metabolic process
CpE19_RS04255	COG1620	l-lactate permease
CpE19_RS04265	COG0019	diaminopimelate decarboxylase activity
CpE19_RS04270	COG0460	homoserine dehydrogenase
CpE19_RS04320	COG0356	it plays a direct role in the translocation of protons across the membrane
CpE19_RS04325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CpE19_RS04330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CpE19_RS04370	COG0346	lactoylglutathione lyase activity
CpE19_RS04395	COG1119	ATPase activity
CpE19_RS04415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CpE19_RS04480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE19_RS04485	COG1120	ATPase activity
CpE19_RS04495	COG0205	6-phosphofructokinase activity
CpE19_RS04505	COG0667	Aldo Keto reductase
CpE19_RS04515	COG0583	DNA-binding transcription factor activity
CpE19_RS04540	COG0668	transmembrane transport
CpE19_RS04545	COG0028	Belongs to the TPP enzyme family
CpE19_RS04580	COG0473	3-isopropylmalate dehydrogenase activity
CpE19_RS04600	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpE19_RS04630	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpE19_RS04665	COG0494	nUDIX hydrolase
CpE19_RS04665	COG0406	alpha-ribazole phosphatase activity
CpE19_RS04685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CpE19_RS04690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CpE19_RS04695	COG1461	Dihydroxyacetone kinase
CpE19_RS04705	COG0511	ligase activity, forming carbon-carbon bonds
CpE19_RS04710	COG0742	ribosomal rna small subunit methyltransferase
CpE19_RS04735	COG0765	amino acid transport
CpE19_RS04780	COG2226	methyltransferase
CpE19_RS04785	COG0539	negative regulation of cytoplasmic translation
CpE19_RS04795	COG0237	dephospho-CoA kinase activity
CpE19_RS04815	COG3973	AAA domain
CpE19_RS04840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CpE19_RS04855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpE19_RS04870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CpE19_RS04885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CpE19_RS04905	COG0165	Argininosuccinate lyase
CpE19_RS04910	COG2835	tetraacyldisaccharide 4'-kinase activity
CpE19_RS04945	COG0647	UMP catabolic process
CpE19_RS04975	COG0494	nUDIX hydrolase
CpE19_RS04980	COG4974	Belongs to the 'phage' integrase family
CpE19_RS05000	COG3104	oligopeptide transport
CpE19_RS05005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CpE19_RS05015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CpE19_RS05030	COG1160	GTP binding
CpE19_RS05035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpE19_RS05045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpE19_RS05050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpE19_RS05055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CpE19_RS05060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE19_RS05065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE19_RS05070	COG1120	ATPase activity
CpE19_RS05075	COG4264	IucA IucC family
CpE19_RS05095	COG0653	protein targeting
CpE19_RS05135	COG1253	flavin adenine dinucleotide binding
CpE19_RS05140	COG0513	Belongs to the DEAD box helicase family
CpE19_RS05145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CpE19_RS05155	COG0598	Magnesium transport protein CorA
CpE19_RS05175	COG0477	Major facilitator Superfamily
CpE19_RS05200	COG0463	Glycosyl transferase, family 2
CpE19_RS05250	COG0300	oxidoreductase activity
CpE19_RS05265	COG0805	protein transport
CpE19_RS05275	COG2378	regulation of single-species biofilm formation
CpE19_RS05295	COG4122	O-methyltransferase activity
CpE19_RS05310	COG1362	aminopeptidase activity
CpE19_RS05330	COG1027	Aspartate ammonia-lyase
CpE19_RS05335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpE19_RS05355	COG1410	methionine synthase
CpE19_RS05355	COG0646	methionine synthase
CpE19_RS05375	COG0667	Aldo Keto reductase
CpE19_RS05385	COG0167	dihydroorotate dehydrogenase activity
CpE19_RS05410	COG1461	Dihydroxyacetone kinase
CpE19_RS05415	COG2376	Dihydroxyacetone kinase
CpE19_RS05425	COG0488	(ABC) transporter
CpE19_RS05490	COG3883	PFAM NLP P60 protein
CpE19_RS05490	COG0791	NLP P60 protein
CpE19_RS05520	COG2848	UPF0210 protein
CpE19_RS05535	COG4932	domain protein
CpE19_RS05535	COG1388	LysM domain
CpE19_RS05540	COG0488	(ABC) transporter
CpE19_RS05545	COG2151	metal-sulfur cluster biosynthetic enzyme
CpE19_RS05550	COG0822	iron-sulfur transferase activity
CpE19_RS05560	COG0396	ATPase activity
CpE19_RS05605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CpE19_RS05610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CpE19_RS05630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpE19_RS05650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CpE19_RS05660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CpE19_RS05700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CpE19_RS05715	COG0242	peptide deformylase activity
CpE19_RS05755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CpE19_RS05765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CpE19_RS05780	COG1090	epimerase
CpE19_RS05805	COG0006	proline dipeptidase activity
CpE19_RS05810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CpE19_RS05815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CpE19_RS05820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CpE19_RS05825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CpE19_RS05835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CpE19_RS05845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CpE19_RS05900	COG1760	l-serine dehydratase
CpE19_RS05930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpE19_RS05935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CpE19_RS05950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CpE19_RS05965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpE19_RS05970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpE19_RS06000	COG1946	Acyl-CoA thioesterase
CpE19_RS06015	COG0156	8-amino-7-oxononanoate synthase activity
CpE19_RS06030	COG1560	Kdo2-lipid A biosynthetic process
CpE19_RS06035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CpE19_RS06050	COG2837	iron assimilation
CpE19_RS06095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CpE19_RS06100	COG3253	May function as heme-dependent peroxidase
CpE19_RS06185	COG2890	protein-(glutamine-N5) methyltransferase activity
CpE19_RS06225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CpE19_RS06230	COG0450	alkyl hydroperoxide reductase
CpE19_RS06245	COG1643	Atp-dependent helicase
CpE19_RS06265	COG1349	DNA-binding transcription factor activity
CpE19_RS06270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CpE19_RS06275	COG1349	DNA-binding transcription factor activity
CpE19_RS06280	COG1105	Belongs to the carbohydrate kinase PfkB family
CpE19_RS06285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE19_RS06285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE19_RS06285	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CpE19_RS06290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpE19_RS06295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpE19_RS06305	COG2233	PERMEase
CpE19_RS06310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CpE19_RS06325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CpE19_RS06340	COG1196	nuclear chromosome segregation
CpE19_RS06360	COG2137	regulation of response to DNA damage stimulus
CpE19_RS06365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CpE19_RS06375	COG1268	BioY protein
CpE19_RS06380	COG1122	ATPase activity
CpE19_RS06390	COG1842	Phage shock protein A
CpE19_RS06395	COG1396	sequence-specific DNA binding
CpE19_RS06420	COG1674	ftsk spoiiie
CpE19_RS06430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CpE19_RS06470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CpE19_RS06480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CpE19_RS06485	COG0534	Mate efflux family protein
CpE19_RS06530	COG3022	response to hydroperoxide
CpE19_RS06535	COG1648	precorrin-2 dehydrogenase activity
CpE19_RS06535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpE19_RS06540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CpE19_RS06545	COG0523	cobalamin synthesis protein
CpE19_RS06550	COG2169	Transcriptional regulator
CpE19_RS06550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CpE19_RS06615	COG0750	zinc metalloprotease
CpE19_RS06675	COG4974	Belongs to the 'phage' integrase family
CpE19_RS06700	COG0681	Belongs to the peptidase S26 family
CpE19_RS06715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE19_RS06715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpE19_RS06715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE19_RS06725	COG0336	Belongs to the RNA methyltransferase TrmD family
CpE19_RS06730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CpE19_RS06750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CpE19_RS06780	COG1115	amino acid carrier protein
CpE19_RS06785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpE19_RS06810	COG0686	Belongs to the AlaDH PNT family
CpE19_RS06815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CpE19_RS06825	COG1929	Belongs to the glycerate kinase type-1 family
CpE19_RS06845	COG0058	SHG alpha-glucan phosphorylase activity
CpE19_RS06855	COG0469	pyruvate kinase activity
CpE19_RS06865	COG0134	indole-3-glycerol-phosphate synthase activity
CpE19_RS06885	COG0483	inositol monophosphate 1-phosphatase activity
CpE19_RS06975	COG1739	Uncharacterized protein family UPF0029
CpE19_RS06980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CpE19_RS07005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CpE19_RS07020	COG0252	asparaginase activity
CpE19_RS07040	COG3599	regulation of cell shape
CpE19_RS07050	COG1799	cell septum assembly
CpE19_RS07055	COG1496	oxidoreductase activity
CpE19_RS07060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CpE19_RS07070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CpE19_RS07100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CpE19_RS07105	COG0768	penicillin binding
CpE19_RS07145	COG0142	geranyltranstransferase activity
CpE19_RS07160	COG0515	serine threonine protein kinase
CpE19_RS07160	COG2815	serine threonine protein kinase
CpE19_RS07165	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CpE19_RS07185	COG1940	carbohydrate kinase activity
CpE19_RS07190	COG0438	transferase activity, transferring glycosyl groups
CpE19_RS07200	COG0791	NLP P60 protein
CpE19_RS07250	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CpE19_RS07255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CpE19_RS07280	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpE19_RS07285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpE19_RS07285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpE19_RS07290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CpE19_RS07295	COG0509	glycine decarboxylation via glycine cleavage system
CpE19_RS07325	COG0174	glutamine synthetase
CpE19_RS07360	COG3547	Transposase (IS116 IS110 IS902 family)
CpE19_RS07365	COG3547	Transposase (IS116 IS110 IS902 family)
CpE19_RS07395	COG2056	Na+-H+ antiporter family
CpE19_RS07405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CpE19_RS07430	COG0174	glutamine synthetase
CpE19_RS07450	COG0557	exoribonuclease II activity
CpE19_RS07465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CpE19_RS07465	COG3323	Protein of unknown function (DUF1653)
CpE19_RS07505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CpE19_RS07510	COG0596	Alpha beta hydrolase
CpE19_RS07535	COG2860	membrane
CpE19_RS07605	COG0423	glycine-tRNA ligase activity
CpE19_RS07630	COG1381	Involved in DNA repair and RecF pathway recombination
CpE19_RS07685	COG1022	Amp-dependent synthetase and ligase
CpE19_RS07730	COG1132	(ABC) transporter
CpE19_RS07735	COG1114	Component of the transport system for branched-chain amino acids
CpE19_RS07750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpE19_RS07765	COG0747	negative chemotaxis
CpE19_RS07770	COG0601	transmembrane transport
CpE19_RS07775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpE19_RS07780	COG4172	Belongs to the ABC transporter superfamily
CpE19_RS07790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CpE19_RS07795	COG2391	methyltransferase activity
CpE19_RS07805	COG0601	transmembrane transport
CpE19_RS07820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpE19_RS07825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpE19_RS07845	COG1280	lysine exporter protein (LysE YggA)
CpE19_RS07865	COG1596	polysaccharide export
CpE19_RS07865	COG1555	photosystem II stabilization
CpE19_RS07870	COG1307	EDD domain protein, DegV family
CpE19_RS07875	COG0406	alpha-ribazole phosphatase activity
CpE19_RS07885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CpE19_RS07900	COG2832	Protein of unknown function (DUF454)
CpE19_RS07905	COG2985	domain, Protein
CpE19_RS07905	COG0569	domain protein
CpE19_RS07930	COG1530	ribonuclease E activity
CpE19_RS07945	COG2423	ornithine cyclodeaminase activity
CpE19_RS07955	COG0285	dihydrofolate synthase activity
CpE19_RS07995	COG0544	peptidyl-prolyl cis-trans isomerase activity
CpE19_RS08030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CpE19_RS08040	COG0668	transmembrane transport
CpE19_RS08115	COG1131	(ABC) transporter
CpE19_RS08120	COG3336	cytochrome c oxidase
CpE19_RS08125	COG1966	Carbon starvation protein
CpE19_RS08140	COG0604	alcohol dehydrogenase
CpE19_RS08165	COG1376	ErfK ybiS ycfS ynhG family protein
CpE19_RS08215	COG1335	isochorismatase
CpE19_RS08260	COG2197	response regulator
CpE19_RS08310	COG1234	tRNA 3'-trailer cleavage
CpE19_RS08335	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CpE19_RS08465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpE19_RS08475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpE19_RS08495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CpE19_RS08515	COG2217	Heavy metal translocating P-type atpase
CpE19_RS08545	COG0033	Phosphoglucomutase
CpE19_RS08560	COG1136	(ABC) transporter
CpE19_RS08560	COG0577	efflux transmembrane transporter activity
CpE19_RS08565	COG0577	efflux transmembrane transporter activity
CpE19_RS08565	COG1136	(ABC) transporter
CpE19_RS08600	COG2197	response regulator
CpE19_RS08615	COG1045	serine acetyltransferase
CpE19_RS08635	COG0371	Dehydrogenase
CpE19_RS08655	COG1271	oxidase subunit
CpE19_RS08660	COG1294	oxidase, subunit
CpE19_RS08665	COG4988	ABC transporter
CpE19_RS08670	COG4988	ABC transporter
CpE19_RS08695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CpE19_RS08725	COG1597	lipid kinase activity
CpE19_RS08740	COG0354	folic acid binding
CpE19_RS08765	COG1780	Probably involved in ribonucleotide reductase function
CpE19_RS08770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpE19_RS08780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpE19_RS08785	COG0047	phosphoribosylformylglycinamidine synthase activity
CpE19_RS08790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpE19_RS08795	COG0386	Belongs to the glutathione peroxidase family
CpE19_RS08815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CpE19_RS08820	COG0569	domain protein
CpE19_RS08825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CpE19_RS08835	COG0537	adenosine 5'-monophosphoramidase activity
CpE19_RS08845	COG2205	protein histidine kinase activity
CpE19_RS08850	COG0745	RESPONSE REGULATOR receiver
CpE19_RS08880	COG0028	Belongs to the TPP enzyme family
CpE19_RS08925	COG1609	Transcriptional regulator
CpE19_RS08935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpE19_RS08955	COG1329	Transcriptional regulator
CpE19_RS08960	COG2847	Copper chaperone PCu(A)C
CpE19_RS08975	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CpE19_RS08985	COG0288	reversible hydration of carbon dioxide
CpE19_RS09010	COG0477	Major facilitator Superfamily
CpE19_RS09015	COG1957	nucleoside hydrolase
CpE19_RS09030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpE19_RS09045	COG1301	dicarboxylic acid transport
CpE19_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
CpE19_RS09055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpE19_RS09060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CpE19_RS09065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CpE19_RS09095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpE19_RS09100	COG0302	gtp cyclohydrolase
CpE19_RS09105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CpE19_RS09110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CpE19_RS09120	COG2027	D-alanyl-D-alanine carboxypeptidase
CpE19_RS09125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CpE19_RS09130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CpE19_RS09130	COG0425	Belongs to the sulfur carrier protein TusA family
CpE19_RS09135	COG1301	dicarboxylic acid transport
CpE19_RS09155	COG2326	polyphosphate kinase activity
CpE19_RS09195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpE19_RS09195	COG2111	Na H antiporter
CpE19_RS09200	COG1006	Multisubunit Na H antiporter MnhC subunit
CpE19_RS09205	COG0651	ATP synthesis coupled electron transport
CpE19_RS09225	COG1051	belongs to the nudix hydrolase family
CpE19_RS09245	COG0242	peptide deformylase activity
CpE19_RS09250	COG0456	acetyltransferase
CpE19_RS09260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CpE19_RS09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpE19_RS09300	COG0280	phosphate acetyltransferase
CpE19_RS09325	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CpE19_RS09355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpE19_RS09360	COG1333	cytochrome c biogenesis protein
CpE19_RS09370	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CpE19_RS09375	COG3005	denitrification pathway
CpE19_RS09400	COG4129	membrane
CpE19_RS09435	COG0191	fructose-bisphosphate aldolase activity
CpE19_RS09450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CpE19_RS09465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CpE19_RS09525	COG3547	Transposase (IS116 IS110 IS902 family)
CpE19_RS09540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CpE19_RS09560	COG1136	(ABC) transporter
CpE19_RS09560	COG0577	efflux transmembrane transporter activity
CpE19_RS09565	COG1136	(ABC) transporter
CpE19_RS09590	COG1012	belongs to the aldehyde dehydrogenase family
CpE19_RS09605	COG0789	Transcriptional regulator
CpE19_RS09620	COG0443	Heat shock 70 kDa protein
CpE19_RS09650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpE19_RS09655	COG0601	transmembrane transport
CpE19_RS09675	COG0247	lactate metabolic process
CpE19_RS09675	COG2181	nitrate reductase activity
CpE19_RS09690	COG1120	ATPase activity
CpE19_RS09695	COG4139	cobalamin transport
CpE19_RS09705	COG0829	nickel cation binding
CpE19_RS09710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CpE19_RS09715	COG0830	nickel cation binding
CpE19_RS09720	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CpE19_RS09725	COG0804	urea catabolic process
CpE19_RS09730	COG0832	Belongs to the urease beta subunit family
CpE19_RS09735	COG0831	urea catabolic process
CpE19_RS09755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpE19_RS09755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpE19_RS09775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CpE19_RS09790	COG1012	belongs to the aldehyde dehydrogenase family
CpE19_RS09800	COG1472	Belongs to the glycosyl hydrolase 3 family
CpE19_RS09810	COG4981	capsule polysaccharide biosynthetic process
CpE19_RS09815	COG2755	lipolytic protein G-D-S-L family
CpE19_RS09815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpE19_RS09825	COG0438	transferase activity, transferring glycosyl groups
CpE19_RS09830	COG0500	methyltransferase
CpE19_RS09875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpE19_RS09880	COG3321	synthase
CpE19_RS09880	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CpE19_RS09880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CpE19_RS09885	COG0318	PFAM AMP-dependent synthetase and ligase
CpE19_RS09890	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpE19_RS09900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpE19_RS09900	COG5479	isomerase activity
CpE19_RS09915	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CpE19_RS09920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CpE19_RS09925	COG0671	phosphoesterase, PA-phosphatase related
CpE19_RS09930	COG1216	Glycosyl transferase, family 2
CpE19_RS09950	COG0584	glycerophosphoryl diester phosphodiesterase
CpE19_RS09955	COG2271	Major facilitator Superfamily
CpE19_RS09975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpE19_RS09985	COG0561	phosphatase activity
CpE19_RS10000	COG2188	Transcriptional regulator
CpE19_RS10020	COG0077	Prephenate dehydratase
CpE19_RS10025	COG0154	amidase activity
CpE19_RS10035	COG1316	TRANSCRIPTIONal
CpE19_RS10050	COG1115	amino acid carrier protein
CpE19_RS10070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CpE19_RS10100	COG0431	NADPH-dependent FMN reductase
CpE19_RS10105	COG2814	Major facilitator Superfamily
CpE19_RS10120	COG2271	Major facilitator Superfamily
CpE19_RS10135	COG5650	phosphatidylinositol metabolic process
CpE19_RS10155	COG2197	response regulator
CpE19_RS10170	COG3764	Sortase (surface protein transpeptidase)
CpE19_RS10175	COG0706	membrane insertase activity
CpE19_RS10200	COG0564	pseudouridine synthase activity
CpE19_RS10245	COG1842	Phage shock protein A
CpE19_RS10250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CpE19_RS10265	COG0477	Major facilitator Superfamily
CpE19_RS10270	COG0305	Participates in initiation and elongation during chromosome replication
CpE19_RS10305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpE19_RS10325	COG0300	oxidoreductase activity
CpE19_RS10340	COG0586	Pfam SNARE associated Golgi protein
CpE19_RS10345	COG0783	Belongs to the Dps family
CpE19_RS10350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpE19_RS10355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CpE19_RS10355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CpE19_RS10365	COG1511	domain protein
CpE19_RS10390	COG4585	Histidine kinase
CpE19_RS10395	COG2197	response regulator
CpE19_RS10410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CpE19_RS10425	COG2186	Transcriptional regulator
CpE19_RS10430	COG0747	negative chemotaxis
CpE19_RS10435	COG0601	transmembrane transport
CpE19_RS10440	COG0444	Belongs to the ABC transporter superfamily
CpE19_RS10445	COG4608	Belongs to the ABC transporter superfamily
CpE19_RS10450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CpE19_RS10490	COG3422	double-strand break repair
CpE19_RS10505	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CpE19_RS10525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CpE19_RS10530	COG0512	Glutamine amidotransferase of anthranilate synthase
CpE19_RS10540	COG0134	indole-3-glycerol-phosphate synthase activity
CpE19_RS10540	COG0135	phosphoribosylanthranilate isomerase activity
CpE19_RS10575	COG1687	branched-chain amino acid
CpE19_RS10580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CpE19_RS10585	COG1678	Uncharacterized ACR, COG1678
CpE19_RS10590	COG0617	tRNA 3'-terminal CCA addition
CpE19_RS10625	COG3409	Peptidoglycan-binding domain 1 protein
CpE19_RS10625	COG0860	N-Acetylmuramoyl-L-alanine amidase
CpE19_RS10640	COG1192	Involved in chromosome partitioning
CpE19_RS10655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CpE19_RS10665	COG0230	Belongs to the bacterial ribosomal protein bL34 family