locus-tag	class	description
CpE7_RS00010	COG0592	DNA-directed DNA polymerase activity
CpE7_RS00025	COG0187	DNA topoisomerase II activity
CpE7_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CpE7_RS00135	COG1120	ATPase activity
CpE7_RS00140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS00145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS00150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpE7_RS00160	COG2815	serine threonine protein kinase
CpE7_RS00160	COG0515	serine threonine protein kinase
CpE7_RS00165	COG0515	serine threonine protein kinase
CpE7_RS00170	COG0768	penicillin binding
CpE7_RS00190	COG1716	ATPase activity
CpE7_RS00190	COG1716	ATPase activity
CpE7_RS00220	COG1120	ATPase activity
CpE7_RS00225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS00230	COG2239	Acts as a magnesium transporter
CpE7_RS00235	COG0366	Alpha amylase catalytic
CpE7_RS00290	COG0517	IMP dehydrogenase activity
CpE7_RS00290	COG1125	glycine betaine transport
CpE7_RS00300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpE7_RS00320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CpE7_RS00330	COG3409	Peptidoglycan-binding domain 1 protein
CpE7_RS00330	COG3757	hydrolase, family 25
CpE7_RS00355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CpE7_RS00380	COG1846	Transcriptional regulator
CpE7_RS00395	COG3180	Ammonia monooxygenase
CpE7_RS00405	COG0730	response to heat
CpE7_RS00420	COG1643	Atp-dependent helicase
CpE7_RS00430	COG0519	Catalyzes the synthesis of GMP from XMP
CpE7_RS00440	COG0393	Putative heavy-metal-binding
CpE7_RS00445	COG2501	S4 domain
CpE7_RS00470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CpE7_RS00475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CpE7_RS00485	COG3590	peptidase
CpE7_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
CpE7_RS00520	COG0277	FAD linked oxidase domain protein
CpE7_RS00550	COG1216	Glycosyl transferase, family 2
CpE7_RS00560	COG1121	(ABC) transporter
CpE7_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpE7_RS00575	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpE7_RS00600	COG0604	alcohol dehydrogenase
CpE7_RS00625	COG0471	metal ion transport
CpE7_RS00635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpE7_RS00635	COG1263	PTS System
CpE7_RS00640	COG1263	PTS System
CpE7_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpE7_RS00640	COG2190	(PTS) system
CpE7_RS00665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpE7_RS00680	COG0287	Prephenate dehydrogenase
CpE7_RS00705	COG0343	queuine tRNA-ribosyltransferase activity
CpE7_RS00715	COG2610	gluconate transmembrane transporter activity
CpE7_RS00720	COG3265	gluconokinase activity
CpE7_RS00725	COG1063	alcohol dehydrogenase
CpE7_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
CpE7_RS00745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpE7_RS00770	COG2610	gluconate transmembrane transporter activity
CpE7_RS00775	COG2084	Dehydrogenase
CpE7_RS00790	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpE7_RS00800	COG3442	glutamine amidotransferase
CpE7_RS00805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CpE7_RS00815	COG0778	Nitroreductase
CpE7_RS00820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CpE7_RS00825	COG2390	Transcriptional regulator
CpE7_RS00830	COG0813	purine-nucleoside phosphorylase activity
CpE7_RS00845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpE7_RS00865	COG0697	spore germination
CpE7_RS00870	COG0527	aspartate kinase activity
CpE7_RS00930	COG1840	ABC-type Fe3 transport system, periplasmic component
CpE7_RS00965	COG0651	ATP synthesis coupled electron transport
CpE7_RS00975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpE7_RS00975	COG2111	Na H antiporter
CpE7_RS00995	COG4152	abc transporter atp-binding protein
CpE7_RS01025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpE7_RS01050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CpE7_RS01070	COG0494	nUDIX hydrolase
CpE7_RS01140	COG1205	dead DEAH box helicase
CpE7_RS01140	COG1111	helicase
CpE7_RS01150	COG1754	DNA topoisomerase type I activity
CpE7_RS01150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CpE7_RS01155	COG1297	OPT oligopeptide transporter protein
CpE7_RS01165	COG0470	DNA polymerase III
CpE7_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
CpE7_RS01190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CpE7_RS01200	COG1088	dTDP-glucose 4,6-dehydratase activity
CpE7_RS01210	COG1505	serine-type exopeptidase activity
CpE7_RS01225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CpE7_RS01230	COG3800	Transcriptional regulator
CpE7_RS01230	COG1396	sequence-specific DNA binding
CpE7_RS01240	COG1053	succinate dehydrogenase
CpE7_RS01245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CpE7_RS01255	COG2733	membrane
CpE7_RS01265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CpE7_RS01285	COG1882	Formate acetyltransferase
CpE7_RS01305	COG0318	PFAM AMP-dependent synthetase and ligase
CpE7_RS01320	COG5002	protein histidine kinase activity
CpE7_RS01325	COG0745	RESPONSE REGULATOR receiver
CpE7_RS01345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CpE7_RS01365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CpE7_RS01365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CpE7_RS01395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpE7_RS01395	COG1648	precorrin-2 dehydrogenase activity
CpE7_RS01410	COG2217	Heavy metal translocating P-type atpase
CpE7_RS01420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CpE7_RS01435	COG0406	alpha-ribazole phosphatase activity
CpE7_RS01445	COG0785	Cytochrome C biogenesis protein
CpE7_RS01455	COG0275	rRNA processing
CpE7_RS01470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS01475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpE7_RS01510	COG4948	Mandelate Racemase Muconate Lactonizing
CpE7_RS01535	COG0039	L-malate dehydrogenase activity
CpE7_RS01540	COG0644	oxidoreductase
CpE7_RS01545	COG0142	geranyltranstransferase activity
CpE7_RS01570	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpE7_RS01600	COG1902	pentaerythritol trinitrate reductase activity
CpE7_RS01620	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpE7_RS01630	COG1121	(ABC) transporter
CpE7_RS01635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpE7_RS01665	COG2197	response regulator
CpE7_RS01675	COG1131	(ABC) transporter
CpE7_RS01690	COG0701	Predicted permease
CpE7_RS01760	COG1302	Protein conserved in bacteria
CpE7_RS01860	COG0814	amino acid
CpE7_RS01865	COG1760	l-serine dehydratase
CpE7_RS01870	COG0252	asparaginase activity
CpE7_RS01875	COG0671	phosphoesterase, PA-phosphatase related
CpE7_RS01925	COG1175	transmembrane transport
CpE7_RS01930	COG3833	ABC-type maltose transport systems, permease component
CpE7_RS01950	COG3842	ATPase activity
CpE7_RS01955	COG0201	protein transport
CpE7_RS02005	COG0203	ribosomal protein L17
CpE7_RS02025	COG1404	Belongs to the peptidase S8 family
CpE7_RS02095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CpE7_RS02165	COG0516	GMP reductase activity
CpE7_RS02210	COG2011	ABC-type metal ion transport system permease component
CpE7_RS02220	COG1464	Belongs to the NlpA lipoprotein family
CpE7_RS02225	COG1464	Belongs to the NlpA lipoprotein family
CpE7_RS02245	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpE7_RS02250	COG1121	(ABC) transporter
CpE7_RS02260	COG1321	iron dependent repressor
CpE7_RS02260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpE7_RS02265	COG1321	iron dependent repressor
CpE7_RS02270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CpE7_RS02275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CpE7_RS02310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS02315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CpE7_RS02330	COG2838	Isocitrate dehydrogenase
CpE7_RS02335	COG2814	Major facilitator Superfamily
CpE7_RS02340	COG4978	Transcriptional regulator
CpE7_RS02340	COG0789	Transcriptional regulator
CpE7_RS02355	COG0180	Tryptophanyl-tRNA synthetase
CpE7_RS02360	COG1295	ribonuclease BN
CpE7_RS02365	COG1686	Belongs to the peptidase S11 family
CpE7_RS02400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpE7_RS02405	COG1473	amidohydrolase
CpE7_RS02405	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CpE7_RS02430	COG4770	biotin carboxylase activity
CpE7_RS02435	COG2897	thiosulfate sulfurtransferase activity
CpE7_RS02445	COG2755	lipolytic protein G-D-S-L family
CpE7_RS02445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpE7_RS02455	COG0424	maF-like protein
CpE7_RS02460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CpE7_RS02465	COG1609	Transcriptional regulator
CpE7_RS02475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpE7_RS02480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpE7_RS02485	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CpE7_RS02485	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CpE7_RS02535	COG1316	TRANSCRIPTIONal
CpE7_RS02545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CpE7_RS02580	COG1482	cell wall glycoprotein biosynthetic process
CpE7_RS02605	COG0745	RESPONSE REGULATOR receiver
CpE7_RS02610	COG5002	protein histidine kinase activity
CpE7_RS02625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CpE7_RS02665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CpE7_RS02670	COG2135	peptidase activity
CpE7_RS02675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CpE7_RS02710	COG0513	Belongs to the DEAD box helicase family
CpE7_RS02735	COG0210	DNA helicase
CpE7_RS02745	COG2816	NAD+ diphosphatase activity
CpE7_RS02770	COG3480	Lon protease (S16) C-terminal proteolytic domain
CpE7_RS02895	COG0483	inositol monophosphate 1-phosphatase activity
CpE7_RS02900	COG0483	inositol monophosphate 1-phosphatase activity
CpE7_RS02915	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CpE7_RS02925	COG2884	Cell division ATP-binding protein ftsE
CpE7_RS02930	COG2177	Part of the ABC transporter FtsEX involved in
CpE7_RS02945	COG0288	reversible hydration of carbon dioxide
CpE7_RS02995	COG0564	pseudouridine synthase activity
CpE7_RS03020	COG0706	membrane insertase activity
CpE7_RS03025	COG3764	Sortase (surface protein transpeptidase)
CpE7_RS03040	COG2197	response regulator
CpE7_RS03060	COG5650	phosphatidylinositol metabolic process
CpE7_RS03070	COG2271	Major facilitator Superfamily
CpE7_RS03090	COG2814	Major facilitator Superfamily
CpE7_RS03095	COG0431	NADPH-dependent FMN reductase
CpE7_RS03125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CpE7_RS03155	COG1316	TRANSCRIPTIONal
CpE7_RS03165	COG0154	amidase activity
CpE7_RS03190	COG2188	Transcriptional regulator
CpE7_RS03205	COG0561	phosphatase activity
CpE7_RS03215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpE7_RS03220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS03235	COG2271	Major facilitator Superfamily
CpE7_RS03240	COG0584	glycerophosphoryl diester phosphodiesterase
CpE7_RS03250	COG0671	phosphoesterase, PA-phosphatase related
CpE7_RS03260	COG1216	Glycosyl transferase, family 2
CpE7_RS03265	COG0671	phosphoesterase, PA-phosphatase related
CpE7_RS03270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CpE7_RS03275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CpE7_RS03290	COG5479	isomerase activity
CpE7_RS03290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpE7_RS03300	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpE7_RS03305	COG0318	PFAM AMP-dependent synthetase and ligase
CpE7_RS03310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CpE7_RS03310	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CpE7_RS03310	COG3321	synthase
CpE7_RS03315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpE7_RS03360	COG0500	methyltransferase
CpE7_RS03365	COG0438	transferase activity, transferring glycosyl groups
CpE7_RS03380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpE7_RS03380	COG2755	lipolytic protein G-D-S-L family
CpE7_RS03385	COG4981	capsule polysaccharide biosynthetic process
CpE7_RS03395	COG1472	Belongs to the glycosyl hydrolase 3 family
CpE7_RS03405	COG1012	belongs to the aldehyde dehydrogenase family
CpE7_RS03420	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CpE7_RS03435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpE7_RS03435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpE7_RS03460	COG0831	urea catabolic process
CpE7_RS03465	COG0832	Belongs to the urease beta subunit family
CpE7_RS03470	COG0804	urea catabolic process
CpE7_RS03475	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CpE7_RS03480	COG0830	nickel cation binding
CpE7_RS03485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CpE7_RS03490	COG0829	nickel cation binding
CpE7_RS03500	COG4139	cobalamin transport
CpE7_RS03505	COG1120	ATPase activity
CpE7_RS03520	COG2181	nitrate reductase activity
CpE7_RS03520	COG0247	lactate metabolic process
CpE7_RS03575	COG0443	Heat shock 70 kDa protein
CpE7_RS03590	COG0789	Transcriptional regulator
CpE7_RS03630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CpE7_RS03635	COG1136	(ABC) transporter
CpE7_RS03640	COG0577	efflux transmembrane transporter activity
CpE7_RS03640	COG1136	(ABC) transporter
CpE7_RS03690	COG1131	(ABC) transporter
CpE7_RS03730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CpE7_RS03745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CpE7_RS03760	COG0191	fructose-bisphosphate aldolase activity
CpE7_RS03805	COG4129	membrane
CpE7_RS03820	COG3005	denitrification pathway
CpE7_RS03825	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CpE7_RS03835	COG1333	cytochrome c biogenesis protein
CpE7_RS03840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpE7_RS03870	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CpE7_RS03875	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CpE7_RS03895	COG0280	phosphate acetyltransferase
CpE7_RS03910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpE7_RS03935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CpE7_RS03945	COG0456	acetyltransferase
CpE7_RS03950	COG0242	peptide deformylase activity
CpE7_RS03970	COG1051	belongs to the nudix hydrolase family
CpE7_RS03990	COG0651	ATP synthesis coupled electron transport
CpE7_RS03995	COG1006	Multisubunit Na H antiporter MnhC subunit
CpE7_RS04000	COG2111	Na H antiporter
CpE7_RS04000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpE7_RS04045	COG2326	polyphosphate kinase activity
CpE7_RS04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CpE7_RS04070	COG1301	dicarboxylic acid transport
CpE7_RS04075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CpE7_RS04075	COG0425	Belongs to the sulfur carrier protein TusA family
CpE7_RS04080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CpE7_RS04085	COG2027	D-alanyl-D-alanine carboxypeptidase
CpE7_RS04095	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CpE7_RS04100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CpE7_RS04105	COG0302	gtp cyclohydrolase
CpE7_RS04110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpE7_RS04140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CpE7_RS04145	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CpE7_RS04150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpE7_RS04155	COG1012	belongs to the aldehyde dehydrogenase family
CpE7_RS04160	COG1301	dicarboxylic acid transport
CpE7_RS04175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpE7_RS04190	COG1957	nucleoside hydrolase
CpE7_RS04195	COG0477	Major facilitator Superfamily
CpE7_RS04225	COG0288	reversible hydration of carbon dioxide
CpE7_RS04235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CpE7_RS04250	COG2847	Copper chaperone PCu(A)C
CpE7_RS04255	COG1329	Transcriptional regulator
CpE7_RS04275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpE7_RS04285	COG1609	Transcriptional regulator
CpE7_RS04335	COG0028	Belongs to the TPP enzyme family
CpE7_RS04365	COG0745	RESPONSE REGULATOR receiver
CpE7_RS04370	COG2205	protein histidine kinase activity
CpE7_RS04380	COG0537	adenosine 5'-monophosphoramidase activity
CpE7_RS04385	COG0151	Belongs to the GarS family
CpE7_RS04390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CpE7_RS04395	COG0569	domain protein
CpE7_RS04400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CpE7_RS04420	COG0386	Belongs to the glutathione peroxidase family
CpE7_RS04425	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpE7_RS04430	COG0047	phosphoribosylformylglycinamidine synthase activity
CpE7_RS04435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpE7_RS04445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpE7_RS04450	COG1780	Probably involved in ribonucleotide reductase function
CpE7_RS04475	COG0354	folic acid binding
CpE7_RS04490	COG1597	lipid kinase activity
CpE7_RS04520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CpE7_RS04545	COG1132	(ABC) transporter
CpE7_RS04550	COG4988	ABC transporter
CpE7_RS04555	COG1294	oxidase, subunit
CpE7_RS04560	COG1271	oxidase subunit
CpE7_RS04580	COG0371	Dehydrogenase
CpE7_RS04600	COG1045	serine acetyltransferase
CpE7_RS04615	COG2197	response regulator
CpE7_RS04655	COG0647	UMP catabolic process
CpE7_RS04670	COG0497	DNA recombination
CpE7_RS04685	COG0494	nUDIX hydrolase
CpE7_RS04690	COG4974	Belongs to the 'phage' integrase family
CpE7_RS04710	COG3104	oligopeptide transport
CpE7_RS04715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CpE7_RS04725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CpE7_RS04740	COG1160	GTP binding
CpE7_RS04755	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpE7_RS04760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpE7_RS04765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CpE7_RS04770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS04780	COG1120	ATPase activity
CpE7_RS04785	COG4264	IucA IucC family
CpE7_RS04795	COG3547	Transposase (IS116 IS110 IS902 family)
CpE7_RS04820	COG3012	SEC-C Motif Domain Protein
CpE7_RS04830	COG0653	protein targeting
CpE7_RS04870	COG1253	flavin adenine dinucleotide binding
CpE7_RS04875	COG0513	Belongs to the DEAD box helicase family
CpE7_RS04880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CpE7_RS04890	COG0598	Magnesium transport protein CorA
CpE7_RS04910	COG0477	Major facilitator Superfamily
CpE7_RS04940	COG0463	Glycosyl transferase, family 2
CpE7_RS04990	COG0300	oxidoreductase activity
CpE7_RS05005	COG0805	protein transport
CpE7_RS05015	COG2378	regulation of single-species biofilm formation
CpE7_RS05035	COG4122	O-methyltransferase activity
CpE7_RS05050	COG1362	aminopeptidase activity
CpE7_RS05070	COG1027	Aspartate ammonia-lyase
CpE7_RS05075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpE7_RS05095	COG1410	methionine synthase
CpE7_RS05095	COG0646	methionine synthase
CpE7_RS05115	COG0667	Aldo Keto reductase
CpE7_RS05125	COG0167	dihydroorotate dehydrogenase activity
CpE7_RS05150	COG1461	Dihydroxyacetone kinase
CpE7_RS05155	COG2376	Dihydroxyacetone kinase
CpE7_RS05165	COG3842	ATPase activity
CpE7_RS05170	COG0488	(ABC) transporter
CpE7_RS05235	COG3883	PFAM NLP P60 protein
CpE7_RS05235	COG0791	NLP P60 protein
CpE7_RS05265	COG2848	UPF0210 protein
CpE7_RS05285	COG0488	(ABC) transporter
CpE7_RS05290	COG2151	metal-sulfur cluster biosynthetic enzyme
CpE7_RS05295	COG0822	iron-sulfur transferase activity
CpE7_RS05305	COG0396	ATPase activity
CpE7_RS05350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CpE7_RS05355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CpE7_RS05375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpE7_RS05395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CpE7_RS05405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CpE7_RS05415	COG0322	excinuclease ABC activity
CpE7_RS05445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CpE7_RS05460	COG0242	peptide deformylase activity
CpE7_RS05500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CpE7_RS05510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CpE7_RS05525	COG1090	epimerase
CpE7_RS05550	COG0006	proline dipeptidase activity
CpE7_RS05555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CpE7_RS05560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CpE7_RS05565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CpE7_RS05570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CpE7_RS05590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CpE7_RS05645	COG1760	l-serine dehydratase
CpE7_RS05670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpE7_RS05675	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CpE7_RS05690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CpE7_RS05705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpE7_RS05710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpE7_RS05740	COG1946	Acyl-CoA thioesterase
CpE7_RS05755	COG0156	8-amino-7-oxononanoate synthase activity
CpE7_RS05770	COG1560	Kdo2-lipid A biosynthetic process
CpE7_RS05775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CpE7_RS05790	COG2837	iron assimilation
CpE7_RS05845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CpE7_RS05850	COG3253	May function as heme-dependent peroxidase
CpE7_RS05935	COG2890	protein-(glutamine-N5) methyltransferase activity
CpE7_RS05975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CpE7_RS05980	COG0450	alkyl hydroperoxide reductase
CpE7_RS05995	COG1643	Atp-dependent helicase
CpE7_RS06015	COG1349	DNA-binding transcription factor activity
CpE7_RS06020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CpE7_RS06025	COG1349	DNA-binding transcription factor activity
CpE7_RS06030	COG1105	Belongs to the carbohydrate kinase PfkB family
CpE7_RS06035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE7_RS06035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CpE7_RS06035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE7_RS06045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpE7_RS06050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpE7_RS06060	COG2233	PERMEase
CpE7_RS06065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CpE7_RS06080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CpE7_RS06095	COG1196	nuclear chromosome segregation
CpE7_RS06115	COG2137	regulation of response to DNA damage stimulus
CpE7_RS06120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CpE7_RS06130	COG1268	BioY protein
CpE7_RS06135	COG1122	ATPase activity
CpE7_RS06145	COG1842	Phage shock protein A
CpE7_RS06150	COG1396	sequence-specific DNA binding
CpE7_RS06175	COG1674	ftsk spoiiie
CpE7_RS06185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CpE7_RS06225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CpE7_RS06235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CpE7_RS06240	COG0534	Mate efflux family protein
CpE7_RS06285	COG3022	response to hydroperoxide
CpE7_RS06290	COG1648	precorrin-2 dehydrogenase activity
CpE7_RS06290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpE7_RS06300	COG0523	cobalamin synthesis protein
CpE7_RS06305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CpE7_RS06305	COG2169	Transcriptional regulator
CpE7_RS06370	COG0750	zinc metalloprotease
CpE7_RS06425	COG4974	Belongs to the 'phage' integrase family
CpE7_RS06455	COG0681	Belongs to the peptidase S26 family
CpE7_RS06470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE7_RS06470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpE7_RS06470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpE7_RS06480	COG0336	Belongs to the RNA methyltransferase TrmD family
CpE7_RS06485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CpE7_RS06505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CpE7_RS06535	COG1115	amino acid carrier protein
CpE7_RS06540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpE7_RS06565	COG0686	Belongs to the AlaDH PNT family
CpE7_RS06570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CpE7_RS06575	COG1929	Belongs to the glycerate kinase type-1 family
CpE7_RS06600	COG0058	SHG alpha-glucan phosphorylase activity
CpE7_RS06610	COG0469	pyruvate kinase activity
CpE7_RS06620	COG0134	indole-3-glycerol-phosphate synthase activity
CpE7_RS06640	COG0483	inositol monophosphate 1-phosphatase activity
CpE7_RS06705	COG2176	DNA-directed DNA polymerase activity
CpE7_RS06730	COG1739	Uncharacterized protein family UPF0029
CpE7_RS06735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CpE7_RS06760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CpE7_RS06775	COG0252	asparaginase activity
CpE7_RS06795	COG3599	regulation of cell shape
CpE7_RS06805	COG1799	cell septum assembly
CpE7_RS06815	COG1496	oxidoreductase activity
CpE7_RS06820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CpE7_RS06830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CpE7_RS06860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CpE7_RS06865	COG0768	penicillin binding
CpE7_RS06910	COG0142	geranyltranstransferase activity
CpE7_RS06925	COG2815	serine threonine protein kinase
CpE7_RS06925	COG0515	serine threonine protein kinase
CpE7_RS06930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CpE7_RS06950	COG1940	carbohydrate kinase activity
CpE7_RS06955	COG0438	transferase activity, transferring glycosyl groups
CpE7_RS06965	COG0791	NLP P60 protein
CpE7_RS07015	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CpE7_RS07020	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CpE7_RS07030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CpE7_RS07045	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpE7_RS07050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpE7_RS07050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpE7_RS07055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CpE7_RS07060	COG0509	glycine decarboxylation via glycine cleavage system
CpE7_RS07090	COG0174	glutamine synthetase
CpE7_RS07235	COG2056	Na+-H+ antiporter family
CpE7_RS07245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CpE7_RS07270	COG0174	glutamine synthetase
CpE7_RS07295	COG0557	exoribonuclease II activity
CpE7_RS07315	COG3323	Protein of unknown function (DUF1653)
CpE7_RS07315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CpE7_RS07355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CpE7_RS07360	COG0596	Alpha beta hydrolase
CpE7_RS07385	COG2860	membrane
CpE7_RS07455	COG0423	glycine-tRNA ligase activity
CpE7_RS07485	COG1381	Involved in DNA repair and RecF pathway recombination
CpE7_RS07540	COG1022	Amp-dependent synthetase and ligase
CpE7_RS07595	COG1114	Component of the transport system for branched-chain amino acids
CpE7_RS07600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpE7_RS07610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpE7_RS07625	COG0747	negative chemotaxis
CpE7_RS07630	COG0601	transmembrane transport
CpE7_RS07635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpE7_RS07640	COG4172	Belongs to the ABC transporter superfamily
CpE7_RS07650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CpE7_RS07655	COG2391	methyltransferase activity
CpE7_RS07665	COG4171	peptide transport system, permease
CpE7_RS07685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpE7_RS07690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpE7_RS07715	COG1280	lysine exporter protein (LysE YggA)
CpE7_RS07740	COG1307	EDD domain protein, DegV family
CpE7_RS07745	COG0406	alpha-ribazole phosphatase activity
CpE7_RS07755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CpE7_RS07770	COG2832	Protein of unknown function (DUF454)
CpE7_RS07775	COG2985	domain, Protein
CpE7_RS07775	COG0569	domain protein
CpE7_RS07800	COG1530	ribonuclease E activity
CpE7_RS07815	COG2423	ornithine cyclodeaminase activity
CpE7_RS07825	COG0285	dihydrofolate synthase activity
CpE7_RS07865	COG0544	peptidyl-prolyl cis-trans isomerase activity
CpE7_RS07900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CpE7_RS07910	COG0668	transmembrane transport
CpE7_RS07990	COG1131	(ABC) transporter
CpE7_RS07995	COG3336	cytochrome c oxidase
CpE7_RS08000	COG1966	Carbon starvation protein
CpE7_RS08020	COG0604	alcohol dehydrogenase
CpE7_RS08045	COG1376	ErfK ybiS ycfS ynhG family protein
CpE7_RS08055	COG2130	NADP-dependent
CpE7_RS08060	COG1335	isochorismatase
CpE7_RS08105	COG2197	response regulator
CpE7_RS08155	COG1234	tRNA 3'-trailer cleavage
CpE7_RS08180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CpE7_RS08225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpE7_RS08235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpE7_RS08255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CpE7_RS08320	COG0033	Phosphoglucomutase
CpE7_RS08335	COG0577	efflux transmembrane transporter activity
CpE7_RS08335	COG1136	(ABC) transporter
CpE7_RS08340	COG0577	efflux transmembrane transporter activity
CpE7_RS08340	COG1136	(ABC) transporter
CpE7_RS08370	COG2835	tetraacyldisaccharide 4'-kinase activity
CpE7_RS08375	COG0165	Argininosuccinate lyase
CpE7_RS08395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CpE7_RS08410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CpE7_RS08425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpE7_RS08440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CpE7_RS08455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpE7_RS08465	COG3973	AAA domain
CpE7_RS08485	COG0237	dephospho-CoA kinase activity
CpE7_RS08495	COG0539	negative regulation of cytoplasmic translation
CpE7_RS08500	COG2226	methyltransferase
CpE7_RS08525	COG0765	amino acid transport
CpE7_RS08550	COG0742	ribosomal rna small subunit methyltransferase
CpE7_RS08555	COG0511	ligase activity, forming carbon-carbon bonds
CpE7_RS08565	COG1461	Dihydroxyacetone kinase
CpE7_RS08570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CpE7_RS08575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CpE7_RS08630	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpE7_RS08660	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpE7_RS08680	COG0473	3-isopropylmalate dehydrogenase activity
CpE7_RS08720	COG0668	transmembrane transport
CpE7_RS08745	COG0583	DNA-binding transcription factor activity
CpE7_RS08755	COG0667	Aldo Keto reductase
CpE7_RS08765	COG0205	6-phosphofructokinase activity
CpE7_RS08775	COG1120	ATPase activity
CpE7_RS08780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpE7_RS08845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CpE7_RS08865	COG1119	ATPase activity
CpE7_RS08890	COG0346	lactoylglutathione lyase activity
CpE7_RS08935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CpE7_RS08940	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CpE7_RS08945	COG0356	it plays a direct role in the translocation of protons across the membrane
CpE7_RS08995	COG0460	homoserine dehydrogenase
CpE7_RS09000	COG0019	diaminopimelate decarboxylase activity
CpE7_RS09010	COG1620	l-lactate permease
CpE7_RS09015	COG0247	lactate metabolic process
CpE7_RS09020	COG1139	Iron-sulfur cluster binding protein
CpE7_RS09025	COG1556	Lactate utilization protein
CpE7_RS09080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CpE7_RS09085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpE7_RS09115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CpE7_RS09135	COG2017	converts alpha-aldose to the beta-anomer
CpE7_RS09155	COG2272	Belongs to the type-B carboxylesterase lipase family
CpE7_RS09160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CpE7_RS09170	COG1132	(ABC) transporter
CpE7_RS09175	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpE7_RS09175	COG0567	Dehydrogenase, E1 component
CpE7_RS09185	COG2239	Acts as a magnesium transporter
CpE7_RS09215	COG4122	O-methyltransferase activity
CpE7_RS09225	COG0297	glycogen (starch) synthase activity
CpE7_RS09255	COG0463	Glycosyl transferase, family 2
CpE7_RS09260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpE7_RS09265	COG1611	Belongs to the LOG family
CpE7_RS09270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpE7_RS09280	COG1113	amino acid transport
CpE7_RS09290	COG1113	amino acid transport
CpE7_RS09325	COG4166	transmembrane transport
CpE7_RS09330	COG1217	gtp-binding protein TYPA
CpE7_RS09360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpE7_RS09365	COG0601	transmembrane transport
CpE7_RS09370	COG4166	transmembrane transport
CpE7_RS09380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CpE7_RS09390	COG1122	ATPase activity
CpE7_RS09395	COG4721	ABC-type cobalt transport system, permease component
CpE7_RS09405	COG2354	Protein conserved in bacteria
CpE7_RS09410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CpE7_RS09420	COG1132	(ABC) transporter
CpE7_RS09425	COG2824	Alkylphosphonate utilization operon protein PhnA
CpE7_RS09440	COG0012	GTP binding
CpE7_RS09475	COG1494	fructose-1,6-bisphosphatase
CpE7_RS09480	COG0114	fumarate hydratase activity
CpE7_RS09550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CpE7_RS09615	COG3956	TIGRFAM MazG family protein
CpE7_RS09620	COG0531	amino acid
CpE7_RS09630	COG1309	transcriptional regulator
CpE7_RS09645	COG2132	Multicopper oxidase
CpE7_RS09650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CpE7_RS09655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CpE7_RS09660	COG1523	belongs to the glycosyl hydrolase 13 family
CpE7_RS09685	COG0193	aminoacyl-tRNA hydrolase activity
CpE7_RS09695	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CpE7_RS09740	COG2326	polyphosphate kinase activity
CpE7_RS09755	COG0488	(ABC) transporter
CpE7_RS09770	COG3583	domain protein
CpE7_RS09775	COG0084	hydrolase, TatD family'
CpE7_RS09790	COG3949	Membrane
CpE7_RS09795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpE7_RS09805	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CpE7_RS09815	COG2259	Doxx family
CpE7_RS09835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CpE7_RS09860	COG0315	cyclic pyranopterin monophosphate synthase activity
CpE7_RS09860	COG0521	Mo-molybdopterin cofactor biosynthetic process
CpE7_RS09865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CpE7_RS09870	COG2205	protein histidine kinase activity
CpE7_RS09875	COG0745	RESPONSE REGULATOR receiver
CpE7_RS09885	COG0254	rRNA binding
CpE7_RS09915	COG1309	transcriptional regulator
CpE7_RS09925	COG0765	amino acid transport
CpE7_RS09930	COG0765	amino acid transport
CpE7_RS09935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpE7_RS09940	COG1126	abc transporter atp-binding protein
CpE7_RS09990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpE7_RS10000	COG1201	RNA secondary structure unwinding
CpE7_RS10005	COG1218	3'(2'),5'-bisphosphate nucleotidase
CpE7_RS10020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CpE7_RS10045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpE7_RS10055	COG0601	transmembrane transport
CpE7_RS10060	COG4166	transmembrane transport
CpE7_RS10075	COG0019	diaminopimelate decarboxylase activity
CpE7_RS10080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CpE7_RS10085	COG0534	Mate efflux family protein
CpE7_RS10100	COG3757	hydrolase, family 25
CpE7_RS10110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpE7_RS10120	COG1024	Enoyl-CoA hydratase
CpE7_RS10125	COG0656	L-ascorbic acid biosynthetic process
CpE7_RS10140	COG0545	Peptidyl-prolyl cis-trans isomerase
CpE7_RS10145	COG0372	Belongs to the citrate synthase family
CpE7_RS10165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpE7_RS10170	COG2252	PERMEase
CpE7_RS10195	COG1652	LysM domain
CpE7_RS10205	COG1061	Type III restriction enzyme res subunit
CpE7_RS10245	COG1131	(ABC) transporter
CpE7_RS10260	COG1842	Phage shock protein A
CpE7_RS10265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CpE7_RS10280	COG0477	Major facilitator Superfamily
CpE7_RS10285	COG0305	Participates in initiation and elongation during chromosome replication
CpE7_RS10290	COG3387	PFAM Glycoside hydrolase 15-related
CpE7_RS10305	COG0629	single-stranded DNA binding
CpE7_RS10330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpE7_RS10350	COG0300	oxidoreductase activity
CpE7_RS10365	COG0586	Pfam SNARE associated Golgi protein
CpE7_RS10370	COG0783	Belongs to the Dps family
CpE7_RS10375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpE7_RS10380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CpE7_RS10380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CpE7_RS10390	COG1511	domain protein
CpE7_RS10400	COG1136	(ABC) transporter
CpE7_RS10400	COG0577	efflux transmembrane transporter activity
CpE7_RS10420	COG4585	Histidine kinase
CpE7_RS10425	COG2197	response regulator
CpE7_RS10440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CpE7_RS10455	COG2186	Transcriptional regulator
CpE7_RS10460	COG0747	negative chemotaxis
CpE7_RS10465	COG0601	transmembrane transport
CpE7_RS10470	COG0444	Belongs to the ABC transporter superfamily
CpE7_RS10475	COG4608	Belongs to the ABC transporter superfamily
CpE7_RS10480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CpE7_RS10520	COG3422	double-strand break repair
CpE7_RS10535	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CpE7_RS10555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CpE7_RS10560	COG0512	Glutamine amidotransferase of anthranilate synthase
CpE7_RS10570	COG0134	indole-3-glycerol-phosphate synthase activity
CpE7_RS10570	COG0135	phosphoribosylanthranilate isomerase activity
CpE7_RS10605	COG1687	branched-chain amino acid
CpE7_RS10610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CpE7_RS10615	COG1678	Uncharacterized ACR, COG1678
CpE7_RS10620	COG0617	tRNA 3'-terminal CCA addition
CpE7_RS10655	COG0860	N-Acetylmuramoyl-L-alanine amidase
CpE7_RS10655	COG3409	Peptidoglycan-binding domain 1 protein
CpE7_RS10670	COG1192	Involved in chromosome partitioning
CpE7_RS10685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CpE7_RS10695	COG0230	Belongs to the bacterial ribosomal protein bL34 family