locus-tag class description CPFRC_RS00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CPFRC_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CPFRC_RS00050 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CPFRC_RS00095 ENOG4107SDZ Galactoside transport system permease protein mglC CPFRC_RS00100 ENOG4105C2J ABC transporter CPFRC_RS00140 ENOG4105E0A ABC, transporter CPFRC_RS00145 ENOG4105TVJ transport system, permease CPFRC_RS00150 ENOG4105DQ5 transport system permease protein CPFRC_RS00155 ENOG4108MES Periplasmic binding protein CPFRC_RS00160 ENOG4105XBB septation inhibitor protein CPFRC_RS00165 ENOG4108DT4 serine threonine protein kinase CPFRC_RS00175 ENOG4105CJN penicillin-binding protein CPFRC_RS00195 ENOG4105TV9 FHA Domain-Containing protein CPFRC_RS00195 ENOG4105TV9 FHA Domain-Containing protein CPFRC_RS00225 ENOG4105E0A ABC, transporter CPFRC_RS00230 ENOG4105EHG Permease protein CPFRC_RS00235 ENOG4105CJW magnesium transporter CPFRC_RS00240 ENOG4105CG3 alpha amylase, catalytic region CPFRC_RS00265 ENOG4105K6V RNA polymerase CPFRC_RS00295 ENOG4108IJ8 ABC transporter CPFRC_RS00305 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CPFRC_RS00325 ENOG4105FYV Amp nucleosidase CPFRC_RS00335 ENOG4107YXZ hydrolase, family 25 CPFRC_RS00360 ENOG4108Z0R Transferase CPFRC_RS00375 ENOG4108URH decarboxylase CPFRC_RS00385 ENOG4105K56 Transcriptional regulator CPFRC_RS00400 ENOG4108KK1 membrane protein AbrB duplication CPFRC_RS00410 ENOG4105EJ9 Membrane CPFRC_RS00415 ENOG4106ETB IIa component CPFRC_RS00425 ENOG4105CQ7 ATP-dependent helicase CPFRC_RS00435 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CPFRC_RS00445 ENOG4105K8R UPF0145 protein CPFRC_RS00450 ENOG410848D S4 domain protein YaaA CPFRC_RS00475 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CPFRC_RS00480 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CPFRC_RS00490 ENOG4105C9K Endothelin-converting enzyme 1 CPFRC_RS00510 ENOG4105J1Z Arabinosyltransferase CPFRC_RS00515 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases CPFRC_RS00520 ENOG4108RG3 short-chain dehydrogenase reductase CPFRC_RS00525 ENOG4105IQ5 FAD linked oxidase domain protein CPFRC_RS00555 ENOG4108MKI Glycosyl transferase, family 2 CPFRC_RS00565 ENOG4105DIK (ABC) transporter CPFRC_RS00570 ENOG4107RPQ ABC transporter CPFRC_RS00575 ENOG4107RBD ABC, transporter CPFRC_RS00580 ENOG4105DSE periplasmic solute binding protein CPFRC_RS00605 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CPFRC_RS00630 ENOG4105C8P )-transporter CPFRC_RS00645 ENOG4105CI1 PTS System CPFRC_RS00655 ENOG4105DSQ Nitric oxide reductase CPFRC_RS00670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CPFRC_RS00685 ENOG4105EVN Prephenate dehydrogenase CPFRC_RS00695 ENOG4108Z6B deaminase CPFRC_RS00705 ENOG4105EYF MMPL domain protein CPFRC_RS00710 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CPFRC_RS00720 ENOG4105C6Z Gluconate CPFRC_RS00725 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CPFRC_RS00730 ENOG4105CPQ Dehydrogenase CPFRC_RS00735 ENOG4105CHR reductase CPFRC_RS00750 ENOG4105XT2 Transcriptional regulator CPFRC_RS00775 ENOG4105C6Z Gluconate CPFRC_RS00780 ENOG4105ZXK Dehydrogenase CPFRC_RS00795 ENOG4105ERH Fumarylacetoacetate hydrolase CPFRC_RS00805 ENOG4105F1K Glutamine amidotransferase CPFRC_RS00810 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CPFRC_RS00830 ENOG4107RHR regulatoR CPFRC_RS00835 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CPFRC_RS00850 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CPFRC_RS00860 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CPFRC_RS00875 ENOG4105PP6 Membrane CPFRC_RS00880 ENOG4105CFH Aspartokinase CPFRC_RS00885 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CPFRC_RS00900 ENOG4105CH6 catalase CPFRC_RS00940 ENOG4107QKW extracellular solute-binding protein family 1 CPFRC_RS00945 ENOG4105CXY transporter CPFRC_RS00950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CPFRC_RS00955 ENOG4105BZU Histidine kinase CPFRC_RS00975 ENOG4108JPZ Monovalent cation H antiporter subunit D CPFRC_RS00985 ENOG4105D65 subunit l CPFRC_RS00995 ENOG4108NJC CPFRC_RS01005 ENOG4108IUX (ABC) transporter CPFRC_RS01035 ENOG4105BZ4 penicillin-binding protein CPFRC_RS01040 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CPFRC_RS01060 ENOG4105IJJ transcriptional regulator, crp fnr family CPFRC_RS01080 ENOG4105P8F nudix hydrolase CPFRC_RS01150 ENOG4108I5C dEAD DEAH box helicase CPFRC_RS01160 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CPFRC_RS01165 ENOG4105EPD Oligopeptide transporter, Opt family CPFRC_RS01175 ENOG4107QRG dna polymerase iii CPFRC_RS01190 ENOG4105CEY Amp-dependent synthetase and ligase CPFRC_RS01200 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CPFRC_RS01210 ENOG4105C1B dTDP-glucose 4-6-dehydratase CPFRC_RS01235 ENOG4107QN2 dihydrolipoyl dehydrogenase CPFRC_RS01240 ENOG4105CFF transcriptional regulator CPFRC_RS01255 ENOG4105E33 succinate dehydrogenase CPFRC_RS01265 ENOG4106BRA Membrane CPFRC_RS01275 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CPFRC_RS01295 ENOG4105C6N Formate acetyltransferase CPFRC_RS01315 ENOG4105CEY Amp-dependent synthetase and ligase CPFRC_RS01330 ENOG4105BZU Histidine kinase CPFRC_RS01335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CPFRC_RS01355 ENOG4105II7 pyrroline-5-carboxylate reductase CPFRC_RS01375 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CPFRC_RS01405 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CPFRC_RS01420 ENOG4105C59 p-type ATPase CPFRC_RS01430 ENOG4105C1Q protoporphyrinogen oxidase CPFRC_RS01445 ENOG4108RH7 phosphoglycerate mutase CPFRC_RS01455 ENOG4107QIV Cytochrome c biogenesis protein CPFRC_RS01465 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CPFRC_RS01480 ENOG4105EHG Permease protein CPFRC_RS01485 ENOG4105CRE cytochrome C CPFRC_RS01515 ENOG4105CEE C4-dicarboxylate transporter CPFRC_RS01520 ENOG4107TCW O-succinylbenzoate synthase CPFRC_RS01535 ENOG4105BZF Glycosyl transferase (Group 1 CPFRC_RS01545 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CPFRC_RS01550 ENOG4105P52 geranylgeranyl reductase CPFRC_RS01580 ENOG410683Z Preprotein translocase SecE subunit CPFRC_RS01605 ENOG4105CTZ aminopeptidase c CPFRC_RS01610 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CPFRC_RS01630 ENOG4105DSE periplasmic solute binding protein CPFRC_RS01640 ENOG4105DIK (ABC) transporter CPFRC_RS01645 ENOG4105CC5 ABC transporter CPFRC_RS01670 ENOG4105BZU Histidine kinase CPFRC_RS01675 ENOG4105WH1 Two component transcriptional regulator luxr family CPFRC_RS01685 ENOG4105CJ1 ABC, transporter CPFRC_RS01700 ENOG4108PJD permease CPFRC_RS01770 ENOG4105VBF alkaline shock protein CPFRC_RS01865 ENOG4105C44 Serine transporter CPFRC_RS01870 ENOG4105EJQ L-serine dehydratase CPFRC_RS01875 ENOG4105HDK L-asparaginase CPFRC_RS01880 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CPFRC_RS01930 ENOG4105EG2 ABC transporter, permease CPFRC_RS01955 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CPFRC_RS02005 ENOG4108ZT0 50S ribosomal protein l17 CPFRC_RS02035 ENOG4105EC2 ftsk spoIIIe CPFRC_RS02090 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CPFRC_RS02135 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CPFRC_RS02160 ENOG4107QVP Dehydrogenase CPFRC_RS02205 ENOG4108UMI ABC transporter, permease CPFRC_RS02215 ENOG4105D01 (LipO)protein CPFRC_RS02220 ENOG4105D01 (LipO)protein CPFRC_RS02235 ENOG4105DSE periplasmic solute binding protein CPFRC_RS02240 ENOG4105DIK (ABC) transporter CPFRC_RS02245 ENOG4107RBD ABC, transporter CPFRC_RS02250 ENOG4107RPQ ABC transporter CPFRC_RS02255 ENOG4107R5H iron (metal) dependent repressor, dtxr family CPFRC_RS02260 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CPFRC_RS02265 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CPFRC_RS02300 ENOG4105DQ5 transport system permease protein CPFRC_RS02305 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CPFRC_RS02320 ENOG4105E9K Isocitrate dehydrogenase CPFRC_RS02325 ENOG4105F27 Major Facilitator CPFRC_RS02330 ENOG4108Z5V transcriptional regulator, merr family CPFRC_RS02345 ENOG4105C31 Tryptophanyl-tRNA synthetase CPFRC_RS02350 ENOG4107H3J ribonuclease CPFRC_RS02355 ENOG4105DZ1 carboxypeptidase CPFRC_RS02390 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CPFRC_RS02395 ENOG4107RM1 amidohydrolase CPFRC_RS02420 ENOG4108JIK carboxylase CPFRC_RS02425 ENOG4105KHC sulfurtransferase CPFRC_RS02435 ENOG4105EXC Acyl-transferase CPFRC_RS02445 ENOG4107WR6 Maf-like protein CPFRC_RS02450 ENOG4108RVA ribokinase CPFRC_RS02455 ENOG4105ETE Transcriptional regulator (LacI family CPFRC_RS02465 ENOG4105D8K carboxyl transferase CPFRC_RS02470 ENOG4105D8K carboxyl transferase CPFRC_RS02475 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CPFRC_RS02525 ENOG4107TB5 TRANSCRIPTIONal CPFRC_RS02545 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CPFRC_RS02570 ENOG4105EIP mannose-6-phosphate isomerase CPFRC_RS02595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CPFRC_RS02600 ENOG4105BZU Histidine kinase CPFRC_RS02615 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea CPFRC_RS02655 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CPFRC_RS02660 ENOG4108RAV Conserved protein CPFRC_RS02665 ENOG4108Z66 YbaK ebsC protein CPFRC_RS02700 ENOG4105C1J atp-dependent rna helicase CPFRC_RS02725 ENOG4105C4R Atp-dependent dna helicase CPFRC_RS02735 ENOG4105E09 nadh pyrophosphatase CPFRC_RS02760 ENOG41063PX domain protein CPFRC_RS02805 ENOG4108F3G Type I restriction-modification system, R subunit CPFRC_RS02855 ENOG4105C85 amino acid CPFRC_RS02860 ENOG4107QSA Oxaloacetate decarboxylase CPFRC_RS02865 ENOG4107QX3 carboxylase CPFRC_RS02875 ENOG4107QSA Oxaloacetate decarboxylase CPFRC_RS02885 ENOG4107TK4 histidinol-phosphate phosphatase CPFRC_RS02890 ENOG4107TK4 histidinol-phosphate phosphatase CPFRC_RS02905 ENOG4105CFC Transporter CPFRC_RS02915 ENOG4105CAK Cell division ATP-binding protein ftsE CPFRC_RS02920 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) CPFRC_RS02935 ENOG4107B2H carbonic anhydrase CPFRC_RS02950 ENOG4105CM4 permease protein CPFRC_RS02955 ENOG4108IPW abc transporter atp-binding protein CPFRC_RS02990 ENOG4105CFI type iii restriction protein res subunit CPFRC_RS03000 ENOG4105MS9 Resuscitation-promoting factor CPFRC_RS03025 ENOG4105C7N Xanthine uracil vitamin C permease CPFRC_RS03030 ENOG4105FCS tRNA rRNA methyltransferase CPFRC_RS03050 ENOG4105BZN citrate synthase CPFRC_RS03055 ENOG41081K0 peptidylprolyl cis-trans isomerase CPFRC_RS03070 ENOG4105CV8 reductase CPFRC_RS03075 ENOG4108VUG Enoyl-CoA hydratase CPFRC_RS03085 ENOG4107QN1 sodium solute CPFRC_RS03095 ENOG4108WKN secreted protein CPFRC_RS03110 ENOG4107QI1 Mate efflux family protein CPFRC_RS03135 ENOG4108J59 Extracellular solute-binding protein, family 5 CPFRC_RS03175 ENOG4105ZIR glutaredoxin-like protein CPFRC_RS03190 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo CPFRC_RS03195 ENOG4107QRT dEAD DEAH box helicase CPFRC_RS03205 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CPFRC_RS03255 ENOG4105CDA abc transporter atp-binding protein CPFRC_RS03260 ENOG4107UBR Extracellular solute-binding protein family 3 CPFRC_RS03265 ENOG4108Q1T ABC transporter CPFRC_RS03270 ENOG4105DRP amino acid AbC transporter CPFRC_RS03280 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CPFRC_RS03310 ENOG4105NRA 50s ribosomal protein l31 type b CPFRC_RS03320 ENOG4105ETX regulatoR CPFRC_RS03325 ENOG41062D9 Histidine kinase CPFRC_RS03330 ENOG4105C0H protease CPFRC_RS03335 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CPFRC_RS03360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CPFRC_RS03380 ENOG4108VGI doxx family CPFRC_RS03390 ENOG4105FF9 glycosyl transferase, family 39 CPFRC_RS03400 ENOG4105C94 Transporter CPFRC_RS03405 ENOG4108K88 Membrane CPFRC_RS03420 ENOG4105F8V Hydrolase, tatD family CPFRC_RS03425 ENOG4106839 domain protein CPFRC_RS03440 ENOG4105C5H ABC transporter CPFRC_RS03455 ENOG4105CSR polyphosphate kinase 2 CPFRC_RS03495 ENOG4108HGY Proline imino-peptidase CPFRC_RS03500 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CPFRC_RS03510 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CPFRC_RS03515 ENOG4105EA8 2-Nitropropane dioxygenase CPFRC_RS03535 ENOG4108IUM Glycogen debranching enzyme CPFRC_RS03540 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CPFRC_RS03545 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CPFRC_RS03550 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CPFRC_RS03560 ENOG41082JN Transcriptional regulator CPFRC_RS03570 ENOG4105D5Q Arginine ornithine antiporter CPFRC_RS03575 ENOG4105DXN mazG family CPFRC_RS03635 ENOG4105T1M mycothiol conjugate amidase mca CPFRC_RS03745 ENOG4105C3G gtp-binding protein CPFRC_RS03760 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CPFRC_RS03765 ENOG4105BZ1 (ABC) transporter CPFRC_RS03780 ENOG4105CKW Inner membrane protein yedI CPFRC_RS03790 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CPFRC_RS03795 ENOG4108JJB ABC transporter CPFRC_RS03805 ENOG4105CAT Cytidine monophosphate kinase CPFRC_RS03815 ENOG4108J59 Extracellular solute-binding protein, family 5 CPFRC_RS03820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CPFRC_RS03825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CPFRC_RS03855 ENOG4105CI3 gtp-binding protein typa CPFRC_RS03875 ENOG4108Z4U Ferredoxin CPFRC_RS03895 ENOG4105C85 amino acid CPFRC_RS03905 ENOG4105C85 amino acid CPFRC_RS03925 ENOG4105EEI dihydropteroate synthase CPFRC_RS03930 ENOG4105C3Q Glycosyl transferase, family 2 CPFRC_RS03955 ENOG4107FQX Alpha-acetolactate decarboxylase CPFRC_RS03960 ENOG4107QPH glycogen) synthase CPFRC_RS03970 ENOG4107ZBN O-methyltransferase CPFRC_RS04000 ENOG4105CJW magnesium transporter CPFRC_RS04010 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CPFRC_RS04015 ENOG4105BZ1 (ABC) transporter CPFRC_RS04025 ENOG4105F9E Shikimate 5-dehydrogenase CPFRC_RS04030 ENOG4105EBR Carboxylesterase CPFRC_RS04050 ENOG4107WI4 Aldose-1-epimerase CPFRC_RS04070 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CPFRC_RS04100 ENOG4105CK7 Sodium proline symporter CPFRC_RS04105 ENOG4105C0D helicase CPFRC_RS04130 ENOG4105FS7 Transcriptional regulator CPFRC_RS04160 ENOG41080R8 Conserved Protein CPFRC_RS04165 ENOG4107QR9 Iron-sulfur cluster binding protein CPFRC_RS04170 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CPFRC_RS04175 ENOG4105DAA L-lactate CPFRC_RS04185 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CPFRC_RS04190 ENOG4105D6E homoserine dehydrogenase CPFRC_RS04240 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) CPFRC_RS04245 ENOG4105ZA1 atp synthase CPFRC_RS04250 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CPFRC_RS04320 ENOG4105DKW ABC transporter CPFRC_RS04340 ENOG4105C10 Electron transfer flavoprotein CPFRC_RS04405 ENOG4105EHG Permease protein CPFRC_RS04410 ENOG4105E0A ABC, transporter CPFRC_RS04420 ENOG4105CTQ phosphohexokinase CPFRC_RS04430 ENOG4105CPC Aldo Keto reductase CPFRC_RS04440 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CPFRC_RS04505 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CPFRC_RS04525 ENOG4105ERH Fumarylacetoacetate hydrolase CPFRC_RS04610 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CPFRC_RS04615 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CPFRC_RS04620 ENOG4105DP4 dak2 domain fusion protein ylov CPFRC_RS04630 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CPFRC_RS04635 ENOG4106H78 methyltransferase CPFRC_RS04655 ENOG4108JEH abc transporter atp-binding protein CPFRC_RS04660 ENOG4105E5Q amino acid AbC transporter CPFRC_RS04685 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CPFRC_RS04690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CPFRC_RS04700 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CPFRC_RS04720 ENOG4105EEM helicase CPFRC_RS04730 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CPFRC_RS04745 ENOG41084BS 50S ribosomal protein L35 CPFRC_RS04775 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CPFRC_RS04810 ENOG4105CH7 arginosuccinase CPFRC_RS04815 ENOG4105W49 UPF0434 protein CPFRC_RS04850 ENOG4105DSU hydrolase CPFRC_RS04885 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CPFRC_RS04895 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CPFRC_RS04905 ENOG4105DUX Transporter CPFRC_RS04910 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CPFRC_RS04920 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CPFRC_RS04935 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CPFRC_RS04940 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CPFRC_RS04950 ENOG4108SEA Esterase CPFRC_RS04955 ENOG4105FF5 Membrane CPFRC_RS04960 ENOG4108HUF Transporter CPFRC_RS04965 ENOG4105DQ5 transport system permease protein CPFRC_RS04970 ENOG4108U1V ABC transporter, permease CPFRC_RS04975 ENOG4105E0A ABC, transporter CPFRC_RS04980 ENOG4105DUU IucA IucC family protein CPFRC_RS04990 ENOG410836F Transposase CPFRC_RS05015 ENOG4105K5B UPF0225 protein CPFRC_RS05025 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CPFRC_RS05065 ENOG4105C37 (CBS) domain CPFRC_RS05070 ENOG4105C1J atp-dependent rna helicase CPFRC_RS05075 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CPFRC_RS05085 ENOG4105D7N magnesium and cobalt transport protein CorA CPFRC_RS05105 ENOG4105CSH Transporter CPFRC_RS05130 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CPFRC_RS05145 ENOG4105CTK cobaltochelatase, cobn subunit CPFRC_RS05180 ENOG4108RG3 short-chain dehydrogenase reductase CPFRC_RS05195 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CPFRC_RS05205 ENOG4107TMB Transcriptional regulator CPFRC_RS05225 ENOG4105E5F proteasome CPFRC_RS05240 ENOG4105DFM M18 family aminopeptidase CPFRC_RS05260 ENOG4108IJ0 Aspartate ammonia-lyase CPFRC_RS05265 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CPFRC_RS05285 ENOG4105C3R Methionine synthase CPFRC_RS05305 ENOG4107SET aldo keto reductase CPFRC_RS05315 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CPFRC_RS05340 ENOG4108UTZ Dihydroxyacetone kinase CPFRC_RS05345 ENOG4105CMT Dihydroxyacetone kinase CPFRC_RS05355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CPFRC_RS05360 ENOG4105C5H ABC transporter CPFRC_RS05425 ENOG4105ZXU NLP P60 protein CPFRC_RS05455 ENOG4105CAG UPF0210 protein CPFRC_RS05480 ENOG4105VG1 fes assembly suf system protein CPFRC_RS05485 ENOG4108UNV SUF system FeS assembly protein, NifU family CPFRC_RS05495 ENOG4105C3K feS assembly ATPase SufC CPFRC_RS05515 ENOG4107JC6 Membrane CPFRC_RS05540 ENOG4105CV1 Transketolase (EC 2.2.1.1) CPFRC_RS05545 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CPFRC_RS05585 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CPFRC_RS05595 ENOG4105CHW UPF0052 protein CPFRC_RS05605 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CPFRC_RS05635 ENOG4105DJV ribulose-phosphate 3-epimerase CPFRC_RS05650 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CPFRC_RS05690 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CPFRC_RS05700 ENOG4105CD3 dihydroorotase CPFRC_RS05740 ENOG4105DC7 peptidase M24 CPFRC_RS05760 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CPFRC_RS05780 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CPFRC_RS05830 ENOG4108UZX fmn reductase CPFRC_RS05835 ENOG4105EJQ L-serine dehydratase CPFRC_RS05860 ENOG4105C5X domain protein CPFRC_RS05865 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CPFRC_RS05880 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CPFRC_RS05895 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CPFRC_RS05930 ENOG4105C29 acyl-CoA thioesterase CPFRC_RS05945 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CPFRC_RS05960 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase CPFRC_RS05980 ENOG4105DBE peroxidase CPFRC_RS06035 ENOG4105E0X reductase CPFRC_RS06040 ENOG4107JTW chlorite dismutase CPFRC_RS06125 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CPFRC_RS06165 ENOG4105JNJ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CPFRC_RS06170 ENOG4105D3R alkyl hydroperoxide reductase CPFRC_RS06175 ENOG4105C5Q Transcriptional regulator CPFRC_RS06185 ENOG4105CQ7 ATP-dependent helicase CPFRC_RS06205 ENOG4105E98 transcriptional regulator DeoR family CPFRC_RS06210 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CPFRC_RS06215 ENOG4105E98 transcriptional regulator DeoR family CPFRC_RS06220 ENOG4105DE4 1-phosphofructokinase CPFRC_RS06225 ENOG4105DM4 PTS System CPFRC_RS06235 ENOG4105KRI phosphocarrier protein (HPr CPFRC_RS06240 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CPFRC_RS06250 ENOG4105C2W permease CPFRC_RS06255 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CPFRC_RS06270 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CPFRC_RS06285 ENOG4105C99 atpase involved in dna repair CPFRC_RS06320 ENOG4107ZYJ bioY protein CPFRC_RS06325 ENOG4108JJB ABC transporter CPFRC_RS06330 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CPFRC_RS06340 ENOG4105WBV Transcriptional regulator CPFRC_RS06375 ENOG4105CN5 Metallo-Beta-Lactamase CPFRC_RS06415 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CPFRC_RS06430 ENOG4107QMU Mate efflux family protein CPFRC_RS06475 ENOG4107XFJ UPF0246 protein CPFRC_RS06480 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CPFRC_RS06485 ENOG4105CNG UPF0061 protein CPFRC_RS06490 ENOG4105CKI cobalamin synthesis protein CPFRC_RS06495 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CPFRC_RS06505 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CPFRC_RS06560 ENOG4105DZP Membrane-associated zinc metalloprotease CPFRC_RS06570 ENOG41068X0 Protein of unknown function (DUF2631) CPFRC_RS06615 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CPFRC_RS06640 ENOG4107QYR Signal peptidase i CPFRC_RS06655 ENOG4105DM4 PTS System CPFRC_RS06665 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CPFRC_RS06670 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CPFRC_RS06690 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CPFRC_RS06725 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CPFRC_RS06750 ENOG4105DCF alanine dehydrogenase CPFRC_RS06755 ENOG4107R37 Glutamate dehydrogenase CPFRC_RS06760 ENOG4105BZW Glycerate kinase CPFRC_RS06775 ENOG4105CH2 amidohydrolase CPFRC_RS06795 ENOG4105CA9 Pyruvate kinase CPFRC_RS06805 ENOG4105DK0 Indole-3-glycerol phosphate synthase CPFRC_RS06825 ENOG4108MWI inositol mono-phosphatase CPFRC_RS06890 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CPFRC_RS06915 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CPFRC_RS06920 ENOG4105C7B Threonine dehydratase CPFRC_RS06960 ENOG4105HDK L-asparaginase CPFRC_RS06980 ENOG4107VQS DivIVA family CPFRC_RS06990 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CPFRC_RS06995 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CPFRC_RS07000 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CPFRC_RS07010 ENOG4105DFU Cell wall formation (By similarity) CPFRC_RS07040 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CPFRC_RS07045 ENOG4105CJN penicillin-binding protein CPFRC_RS07095 ENOG41072RD Membrane CPFRC_RS07100 ENOG4105KYH transcriptional regulatory protein CPFRC_RS07110 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CPFRC_RS07130 ENOG4105DKQ ROK family CPFRC_RS07135 ENOG4105JNK Glycosyl transferase (Group 1 CPFRC_RS07145 ENOG4105K4H Nlp p60 protein CPFRC_RS07195 ENOG4108YZT Adenosylcobinamide kinase CPFRC_RS07200 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CPFRC_RS07210 ENOG4105CM2 brancheD-chain amino acid aminotransferase CPFRC_RS07230 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CPFRC_RS07235 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CPFRC_RS07270 ENOG4105C5F glutamine synthetase CPFRC_RS07340 ENOG4107QMH DNA methylase CPFRC_RS07420 ENOG4105D3Y Na H antiporter CPFRC_RS07425 ENOG4105E09 nadh pyrophosphatase CPFRC_RS07430 ENOG4105D98 threonine synthase CPFRC_RS07455 ENOG4105C5F glutamine synthetase CPFRC_RS07480 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CPFRC_RS07500 ENOG4105EGD dinuclear metal center protein, YbgI family CPFRC_RS07525 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CPFRC_RS07540 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CPFRC_RS07545 ENOG4108YIQ Alpha beta hydrolase CPFRC_RS07570 ENOG4105EN6 Membrane CPFRC_RS07640 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CPFRC_RS07670 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CPFRC_RS07725 ENOG4108IQE Amp-dependent synthetase and ligase CPFRC_RS07740 ENOG4105DGW oligopeptidase A CPFRC_RS07745 ENOG4105EBR Carboxylesterase CPFRC_RS07775 ENOG4105CWM branched-chain amino acid transport system II carrier protein CPFRC_RS07780 ENOG4105DEN Luciferase family CPFRC_RS07790 ENOG4105C94 Transporter CPFRC_RS07805 ENOG4105DEF Extracellular solute-binding protein, family 5 CPFRC_RS07815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CPFRC_RS07820 ENOG4108JQ5 ABC transporter CPFRC_RS07830 ENOG4105DFA alanine racemase domain protein CPFRC_RS07835 ENOG4105CUC YeeE YedE family protein CPFRC_RS07865 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CPFRC_RS07870 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CPFRC_RS07895 ENOG4105CCF Lysine exporter protein (Lyse ygga) CPFRC_RS07920 ENOG4107Z8D degv family CPFRC_RS07925 ENOG4105CVJ phosphoglycerate mutase CPFRC_RS07935 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CPFRC_RS07950 ENOG4105WD1 Membrane CPFRC_RS07955 ENOG4105D0C transport protein CPFRC_RS07980 ENOG4105C03 ribonuclease CPFRC_RS07995 ENOG4105CIF Ornithine Cyclodeaminase CPFRC_RS08005 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CPFRC_RS08045 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CPFRC_RS08070 ENOG4105EUB pirin domain protein CPFRC_RS08080 ENOG4105MC2 DSBA oxidoreductase CPFRC_RS08090 ENOG4105D8X mechanosensitive ion channel CPFRC_RS08170 ENOG4108M15 ABC transporter CPFRC_RS08175 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein CPFRC_RS08180 ENOG4105D22 carbon starvation protein CPFRC_RS08195 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CPFRC_RS08200 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CPFRC_RS08205 ENOG4105EMU Dehydrogenase CPFRC_RS08225 ENOG4107UBC ErfK ybiS ycfS ynhG family protein CPFRC_RS08235 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CPFRC_RS08240 ENOG4108RWI nicotinamidase CPFRC_RS08285 ENOG4105WH1 Two component transcriptional regulator luxr family CPFRC_RS08335 ENOG4108RQ5 Beta-lactamase domain-containing protein CPFRC_RS08360 ENOG4107RKP Nicotinate phosphoribosyltransferase CPFRC_RS08405 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CPFRC_RS08415 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CPFRC_RS08420 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CPFRC_RS08425 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CPFRC_RS08435 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CPFRC_RS08500 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CPFRC_RS08515 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CPFRC_RS08520 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CPFRC_RS08570 ENOG4105D7W serine acetyltransferase CPFRC_RS08610 ENOG4105C4M (Ubiquinol oxidase) subunit I CPFRC_RS08615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CPFRC_RS08620 ENOG4108JJ9 ABC, transporter CPFRC_RS08625 ENOG4108JJ9 ABC, transporter CPFRC_RS08650 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CPFRC_RS08680 ENOG4105CBD Diacylglycerol kinase CPFRC_RS08695 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CPFRC_RS08720 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CPFRC_RS08725 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CPFRC_RS08735 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CPFRC_RS08740 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CPFRC_RS08745 ENOG410839H phosphoribosylformylglycinamidine synthase CPFRC_RS08750 ENOG4108V06 Glutathione peroxidase CPFRC_RS08770 ENOG4105C83 adenylosuccinate lyase CPFRC_RS08775 ENOG4107ZYR domain protein CPFRC_RS08780 ENOG4105CZN Potassium uptake protein CPFRC_RS08785 ENOG4105C12 Phosphoribosylglycinamide synthetase CPFRC_RS08790 ENOG4107ZUX Histidine triad (HIT) protein CPFRC_RS08800 ENOG4105BZU Histidine kinase CPFRC_RS08805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CPFRC_RS08835 ENOG4105C7K acetolactate synthase CPFRC_RS08890 ENOG4105C2N RNA methyltransferase TrmH family group 3 CPFRC_RS08910 ENOG4108VJ1 Transcriptional regulator (CarD family CPFRC_RS08930 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CPFRC_RS08940 ENOG4108V9Q carbonic anhydrase CPFRC_RS08960 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CPFRC_RS08970 ENOG41080V3 Major Facilitator superfamily CPFRC_RS08975 ENOG4105DU0 nucleoside hydrolase CPFRC_RS08990 ENOG4105CRK lysyL-tRNA synthetase CPFRC_RS09015 ENOG4105C94 Transporter CPFRC_RS09025 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CPFRC_RS09055 ENOG4105EEI dihydropteroate synthase CPFRC_RS09060 ENOG4105EUJ GTP cyclohydrolase i CPFRC_RS09065 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CPFRC_RS09070 ENOG4108UGV hypoxanthine phosphoribosyltransferase CPFRC_RS09085 ENOG4105F0N pyrophosphate phospho-hydrolase CPFRC_RS09090 ENOG4105VFE sira family CPFRC_RS09095 ENOG4107QJT sodium dicarboxylate symporter CPFRC_RS09115 ENOG4105CEY Amp-dependent synthetase and ligase CPFRC_RS09120 ENOG4105CSR polyphosphate kinase 2 CPFRC_RS09140 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CPFRC_RS09160 ENOG4105D65 subunit l CPFRC_RS09165 ENOG4105MKQ Monovalent cation H antiporter subunit C CPFRC_RS09170 ENOG4108JPZ Monovalent cation H antiporter subunit D CPFRC_RS09190 ENOG4108U8T Mannosyltransferase CPFRC_RS09210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CPFRC_RS09215 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CPFRC_RS09220 ENOG4105CGK Exodeoxyribonuclease III CPFRC_RS09225 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CPFRC_RS09250 ENOG4105CT1 (ABC) transporter CPFRC_RS09265 ENOG4108IJ2 phosphate acetyltransferase CPFRC_RS09285 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CPFRC_RS09290 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CPFRC_RS09320 ENOG4105CRE cytochrome C CPFRC_RS09325 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) CPFRC_RS09335 ENOG4105EAU Plays a role in nitrite reduction (By similarity) CPFRC_RS09340 ENOG4108W6G cytochrome C CPFRC_RS09400 ENOG4107RCW fructose-bisphosphate aldolase CPFRC_RS09415 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CPFRC_RS09430 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CPFRC_RS09470 ENOG4105CJ1 ABC, transporter CPFRC_RS09500 ENOG4105DWV Homoserine O-trans-acetylase CPFRC_RS09510 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CPFRC_RS09515 ENOG4105C19 ABC transporter CPFRC_RS09520 ENOG4105DJY efflux transporter, rnd family, mfp subunit CPFRC_RS09560 ENOG4105KNI merR family transcriptional Regulator CPFRC_RS09575 ENOG4105CFG Acts as a chaperone (By similarity) CPFRC_RS09630 ENOG4105DF6 Fe-S oxidoreductase CPFRC_RS09645 ENOG4105E0A ABC, transporter CPFRC_RS09650 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CPFRC_RS09660 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CPFRC_RS09665 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CPFRC_RS09670 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CPFRC_RS09675 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CPFRC_RS09680 ENOG4105CQM Urea amidohydrolase subunit alpha CPFRC_RS09685 ENOG4105KI2 Urea amidohydrolase subunit beta CPFRC_RS09690 ENOG4108YZ9 Urea amidohydrolase subunit gamma CPFRC_RS09715 ENOG4105CRK lysyL-tRNA synthetase CPFRC_RS09735 ENOG4105C6Y Udp-glucose 6-dehydrogenase CPFRC_RS09750 ENOG4105C26 Dehydrogenase CPFRC_RS09770 ENOG41073B4 coagulation factor 5 8 type domain-containing protein CPFRC_RS09775 ENOG4105EXC Acyl-transferase CPFRC_RS09790 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CPFRC_RS09795 ENOG4108M6P methyltransferase CPFRC_RS09840 ENOG4105D8K carboxyl transferase CPFRC_RS09845 ENOG4107EEY synthase CPFRC_RS09850 ENOG4107RCI amp-dependent synthetase and ligase CPFRC_RS09865 ENOG4107YB1 Trehalose corynomycolyl transferase CPFRC_RS09880 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids CPFRC_RS09885 ENOG4106YN8 Prenyltransferase CPFRC_RS09895 ENOG410602S Transferase CPFRC_RS09905 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CPFRC_RS09915 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CPFRC_RS09920 ENOG4105CXY transporter CPFRC_RS09935 ENOG4105EHG Permease protein CPFRC_RS09940 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CPFRC_RS09950 ENOG4108KP7 hydrolase CPFRC_RS09965 ENOG4105FDP GntR family transcriptional regulator CPFRC_RS09990 ENOG4105DV0 amidase (EC 3.5.1.4 CPFRC_RS10000 ENOG4108KGH TRANSCRIPTIONal CPFRC_RS10030 ENOG4105D9N nucleoside CPFRC_RS10060 ENOG4108YYH Nadph-dependent fmn reductase CPFRC_RS10065 ENOG4105D94 Major Facilitator Superfamily CPFRC_RS10085 ENOG4108VJY integral membrane protein CPFRC_RS10105 ENOG4105WH1 Two component transcriptional regulator luxr family CPFRC_RS10120 ENOG4108RN7 integral membrane protein CPFRC_RS10125 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CPFRC_RS10180 ENOG4105DVE abc transporter atp-binding protein CPFRC_RS10200 ENOG41080RH Thioredoxin CPFRC_RS10215 ENOG41079KZ Major Facilitator Superfamily CPFRC_RS10225 ENOG4105BZP glycoside hydrolase 15-related CPFRC_RS10240 ENOG4107YH6 single-stranded DNA-binding protein CPFRC_RS10265 ENOG4105BZ4 penicillin-binding protein CPFRC_RS10285 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CPFRC_RS10300 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CPFRC_RS10305 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CPFRC_RS10310 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CPFRC_RS10325 ENOG4105ECB domain protein CPFRC_RS10335 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CPFRC_RS10355 ENOG4105ENE Histidine kinase CPFRC_RS10360 ENOG4105WH1 Two component transcriptional regulator luxr family CPFRC_RS10375 ENOG4105CE4 GlcNAc 6-P deacetylase CPFRC_RS10390 ENOG4107EJG GntR family transcriptional regulator CPFRC_RS10395 ENOG4105DEF Extracellular solute-binding protein, family 5 CPFRC_RS10400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CPFRC_RS10410 ENOG4108JQ7 (ABC) transporter CPFRC_RS10415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CPFRC_RS10455 ENOG4106178 UPF0339 protein CPFRC_RS10470 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CPFRC_RS10480 ENOG4105EWK phytoene CPFRC_RS10490 ENOG4105CRQ synthase (Component I) CPFRC_RS10495 ENOG4105RGK anthranilate synthase component ii CPFRC_RS10505 ENOG4105DK0 Indole-3-glycerol phosphate synthase CPFRC_RS10525 ENOG4105DHU Bile acid CPFRC_RS10535 ENOG4105KMT branched-chain amino acid CPFRC_RS10540 ENOG4108UMN azlc family CPFRC_RS10545 ENOG4108UJU UPF0301 protein CPFRC_RS10550 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CPFRC_RS10570 ENOG4105EMN RNA polymerase sigma factor CPFRC_RS10575 ENOG4105C3M thioredoxin reductase CPFRC_RS10580 ENOG4105K63 Thioredoxin CPFRC_RS10585 ENOG4108E1C hydrolase CPFRC_RS10600 ENOG4107QJE Chromosome Partitioning Protein CPFRC_RS10625 ENOG41084CH 50S ribosomal protein l34