locus-tag	class	description
CPFRC_RS00015	COG0592	DNA-directed DNA polymerase activity
CPFRC_RS00030	COG0187	DNA topoisomerase II activity
CPFRC_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPFRC_RS00140	COG1120	ATPase activity
CPFRC_RS00145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS00150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS00155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPFRC_RS00165	COG0515	serine threonine protein kinase
CPFRC_RS00165	COG2815	serine threonine protein kinase
CPFRC_RS00170	COG0515	serine threonine protein kinase
CPFRC_RS00175	COG0768	penicillin binding
CPFRC_RS00195	COG1716	ATPase activity
CPFRC_RS00195	COG1716	ATPase activity
CPFRC_RS00225	COG1120	ATPase activity
CPFRC_RS00230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS00235	COG2239	Acts as a magnesium transporter
CPFRC_RS00240	COG0366	Alpha amylase catalytic
CPFRC_RS00295	COG0517	IMP dehydrogenase activity
CPFRC_RS00295	COG1125	glycine betaine transport
CPFRC_RS00305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPFRC_RS00325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPFRC_RS00335	COG3409	Peptidoglycan-binding domain 1 protein
CPFRC_RS00335	COG3757	hydrolase, family 25
CPFRC_RS00360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CPFRC_RS00385	COG1846	Transcriptional regulator
CPFRC_RS00400	COG3180	Ammonia monooxygenase
CPFRC_RS00410	COG0730	response to heat
CPFRC_RS00425	COG1643	Atp-dependent helicase
CPFRC_RS00435	COG0519	Catalyzes the synthesis of GMP from XMP
CPFRC_RS00445	COG0393	Putative heavy-metal-binding
CPFRC_RS00450	COG2501	S4 domain
CPFRC_RS00475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPFRC_RS00480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPFRC_RS00490	COG3590	peptidase
CPFRC_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
CPFRC_RS00525	COG0277	FAD linked oxidase domain protein
CPFRC_RS00555	COG1216	Glycosyl transferase, family 2
CPFRC_RS00565	COG1121	(ABC) transporter
CPFRC_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPFRC_RS00575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPFRC_RS00580	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPFRC_RS00605	COG0604	alcohol dehydrogenase
CPFRC_RS00630	COG0471	metal ion transport
CPFRC_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPFRC_RS00640	COG1263	PTS System
CPFRC_RS00645	COG2190	(PTS) system
CPFRC_RS00645	COG1263	PTS System
CPFRC_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPFRC_RS00670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPFRC_RS00685	COG0287	Prephenate dehydrogenase
CPFRC_RS00705	COG2409	Drug exporters of the RND superfamily
CPFRC_RS00710	COG0343	queuine tRNA-ribosyltransferase activity
CPFRC_RS00720	COG2610	gluconate transmembrane transporter activity
CPFRC_RS00725	COG3265	gluconokinase activity
CPFRC_RS00730	COG1063	alcohol dehydrogenase
CPFRC_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
CPFRC_RS00750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPFRC_RS00775	COG2610	gluconate transmembrane transporter activity
CPFRC_RS00780	COG2084	Dehydrogenase
CPFRC_RS00795	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPFRC_RS00805	COG3442	glutamine amidotransferase
CPFRC_RS00810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPFRC_RS00825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPFRC_RS00830	COG2390	Transcriptional regulator
CPFRC_RS00835	COG0813	purine-nucleoside phosphorylase activity
CPFRC_RS00850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPFRC_RS00875	COG0697	spore germination
CPFRC_RS00880	COG0527	aspartate kinase activity
CPFRC_RS00940	COG1840	ABC-type Fe3 transport system, periplasmic component
CPFRC_RS00945	COG2271	Major facilitator Superfamily
CPFRC_RS00955	COG3852	Histidine kinase
CPFRC_RS00985	COG2111	Na H antiporter
CPFRC_RS00985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPFRC_RS01005	COG4152	abc transporter atp-binding protein
CPFRC_RS01035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPFRC_RS01060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPFRC_RS01080	COG0494	nUDIX hydrolase
CPFRC_RS01150	COG1205	dead DEAH box helicase
CPFRC_RS01150	COG1111	helicase
CPFRC_RS01160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPFRC_RS01160	COG1754	DNA topoisomerase type I activity
CPFRC_RS01165	COG1297	OPT oligopeptide transporter protein
CPFRC_RS01175	COG0470	DNA polymerase III
CPFRC_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
CPFRC_RS01200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CPFRC_RS01210	COG1088	dTDP-glucose 4,6-dehydratase activity
CPFRC_RS01220	COG1505	serine-type exopeptidase activity
CPFRC_RS01235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPFRC_RS01240	COG1396	sequence-specific DNA binding
CPFRC_RS01240	COG3800	Transcriptional regulator
CPFRC_RS01250	COG1053	succinate dehydrogenase
CPFRC_RS01255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CPFRC_RS01265	COG2733	membrane
CPFRC_RS01275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CPFRC_RS01295	COG1882	Formate acetyltransferase
CPFRC_RS01315	COG0318	PFAM AMP-dependent synthetase and ligase
CPFRC_RS01330	COG5002	protein histidine kinase activity
CPFRC_RS01335	COG0745	RESPONSE REGULATOR receiver
CPFRC_RS01355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPFRC_RS01375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CPFRC_RS01375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPFRC_RS01405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPFRC_RS01405	COG1648	precorrin-2 dehydrogenase activity
CPFRC_RS01420	COG2217	Heavy metal translocating P-type atpase
CPFRC_RS01445	COG0406	alpha-ribazole phosphatase activity
CPFRC_RS01455	COG0785	Cytochrome C biogenesis protein
CPFRC_RS01465	COG0275	rRNA processing
CPFRC_RS01480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS01485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPFRC_RS01515	COG3069	C4-dicarboxylate transmembrane transporter activity
CPFRC_RS01520	COG4948	Mandelate Racemase Muconate Lactonizing
CPFRC_RS01535	COG0438	transferase activity, transferring glycosyl groups
CPFRC_RS01535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPFRC_RS01545	COG0039	L-malate dehydrogenase activity
CPFRC_RS01550	COG0644	oxidoreductase
CPFRC_RS01580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPFRC_RS01605	COG3579	cysteine-type endopeptidase activity
CPFRC_RS01610	COG1902	pentaerythritol trinitrate reductase activity
CPFRC_RS01630	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPFRC_RS01640	COG1121	(ABC) transporter
CPFRC_RS01645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPFRC_RS01675	COG2197	response regulator
CPFRC_RS01685	COG1131	(ABC) transporter
CPFRC_RS01700	COG0701	Predicted permease
CPFRC_RS01770	COG1302	Protein conserved in bacteria
CPFRC_RS01865	COG0814	amino acid
CPFRC_RS01870	COG1760	l-serine dehydratase
CPFRC_RS01875	COG0252	asparaginase activity
CPFRC_RS01880	COG0671	phosphoesterase, PA-phosphatase related
CPFRC_RS01925	COG1175	transmembrane transport
CPFRC_RS01930	COG3833	ABC-type maltose transport systems, permease component
CPFRC_RS01950	COG3842	ATPase activity
CPFRC_RS01955	COG0201	protein transport
CPFRC_RS02005	COG0203	ribosomal protein L17
CPFRC_RS02025	COG1404	Belongs to the peptidase S8 family
CPFRC_RS02035	COG1674	ftsk spoiiie
CPFRC_RS02090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPFRC_RS02160	COG0516	GMP reductase activity
CPFRC_RS02205	COG2011	ABC-type metal ion transport system permease component
CPFRC_RS02215	COG1464	Belongs to the NlpA lipoprotein family
CPFRC_RS02220	COG1464	Belongs to the NlpA lipoprotein family
CPFRC_RS02235	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPFRC_RS02240	COG1121	(ABC) transporter
CPFRC_RS02250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPFRC_RS02250	COG1321	iron dependent repressor
CPFRC_RS02255	COG1321	iron dependent repressor
CPFRC_RS02260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CPFRC_RS02265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CPFRC_RS02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS02305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CPFRC_RS02320	COG2838	Isocitrate dehydrogenase
CPFRC_RS02325	COG2814	Major facilitator Superfamily
CPFRC_RS02330	COG0789	Transcriptional regulator
CPFRC_RS02330	COG4978	Transcriptional regulator
CPFRC_RS02345	COG0180	Tryptophanyl-tRNA synthetase
CPFRC_RS02350	COG1295	ribonuclease BN
CPFRC_RS02355	COG1686	Belongs to the peptidase S11 family
CPFRC_RS02390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPFRC_RS02395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CPFRC_RS02395	COG1473	amidohydrolase
CPFRC_RS02410	COG2814	Major facilitator Superfamily
CPFRC_RS02420	COG4770	biotin carboxylase activity
CPFRC_RS02425	COG2897	thiosulfate sulfurtransferase activity
CPFRC_RS02435	COG2755	lipolytic protein G-D-S-L family
CPFRC_RS02435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPFRC_RS02445	COG0424	maF-like protein
CPFRC_RS02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPFRC_RS02455	COG1609	Transcriptional regulator
CPFRC_RS02465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPFRC_RS02470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPFRC_RS02475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CPFRC_RS02475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CPFRC_RS02525	COG1316	TRANSCRIPTIONal
CPFRC_RS02535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CPFRC_RS02570	COG1482	cell wall glycoprotein biosynthetic process
CPFRC_RS02595	COG0745	RESPONSE REGULATOR receiver
CPFRC_RS02600	COG5002	protein histidine kinase activity
CPFRC_RS02615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CPFRC_RS02655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CPFRC_RS02660	COG2135	peptidase activity
CPFRC_RS02665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPFRC_RS02700	COG0513	Belongs to the DEAD box helicase family
CPFRC_RS02725	COG0210	DNA helicase
CPFRC_RS02735	COG2816	NAD+ diphosphatase activity
CPFRC_RS02760	COG3480	Lon protease (S16) C-terminal proteolytic domain
CPFRC_RS02885	COG0483	inositol monophosphate 1-phosphatase activity
CPFRC_RS02890	COG0483	inositol monophosphate 1-phosphatase activity
CPFRC_RS02905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CPFRC_RS02915	COG2884	Cell division ATP-binding protein ftsE
CPFRC_RS02920	COG2177	Part of the ABC transporter FtsEX involved in
CPFRC_RS02935	COG0288	reversible hydration of carbon dioxide
CPFRC_RS02990	COG1061	Type III restriction enzyme res subunit
CPFRC_RS03000	COG1652	LysM domain
CPFRC_RS03025	COG2252	PERMEase
CPFRC_RS03030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPFRC_RS03050	COG0372	Belongs to the citrate synthase family
CPFRC_RS03055	COG0545	Peptidyl-prolyl cis-trans isomerase
CPFRC_RS03070	COG0656	L-ascorbic acid biosynthetic process
CPFRC_RS03075	COG1024	Enoyl-CoA hydratase
CPFRC_RS03085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPFRC_RS03095	COG3757	hydrolase, family 25
CPFRC_RS03110	COG0534	Mate efflux family protein
CPFRC_RS03115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPFRC_RS03120	COG0019	diaminopimelate decarboxylase activity
CPFRC_RS03135	COG4166	transmembrane transport
CPFRC_RS03150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPFRC_RS03175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CPFRC_RS03190	COG1218	3'(2'),5'-bisphosphate nucleotidase
CPFRC_RS03195	COG1201	RNA secondary structure unwinding
CPFRC_RS03205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPFRC_RS03255	COG1126	abc transporter atp-binding protein
CPFRC_RS03260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPFRC_RS03265	COG0765	amino acid transport
CPFRC_RS03270	COG0765	amino acid transport
CPFRC_RS03310	COG0254	rRNA binding
CPFRC_RS03320	COG0745	RESPONSE REGULATOR receiver
CPFRC_RS03325	COG2205	protein histidine kinase activity
CPFRC_RS03330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPFRC_RS03335	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPFRC_RS03335	COG0315	cyclic pyranopterin monophosphate synthase activity
CPFRC_RS03360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CPFRC_RS03380	COG2259	Doxx family
CPFRC_RS03390	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CPFRC_RS03400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPFRC_RS03405	COG3949	Membrane
CPFRC_RS03420	COG0084	hydrolase, TatD family'
CPFRC_RS03425	COG3583	domain protein
CPFRC_RS03440	COG0488	(ABC) transporter
CPFRC_RS03455	COG2326	polyphosphate kinase activity
CPFRC_RS03495	COG0596	Alpha beta hydrolase
CPFRC_RS03500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPFRC_RS03510	COG0193	aminoacyl-tRNA hydrolase activity
CPFRC_RS03515	COG2070	2-Nitropropane dioxygenase
CPFRC_RS03535	COG1523	belongs to the glycosyl hydrolase 13 family
CPFRC_RS03540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPFRC_RS03545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPFRC_RS03550	COG2132	Multicopper oxidase
CPFRC_RS03560	COG1309	transcriptional regulator
CPFRC_RS03570	COG0531	amino acid
CPFRC_RS03575	COG3956	TIGRFAM MazG family protein
CPFRC_RS03635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CPFRC_RS03705	COG0114	fumarate hydratase activity
CPFRC_RS03710	COG1494	fructose-1,6-bisphosphatase
CPFRC_RS03745	COG0012	GTP binding
CPFRC_RS03760	COG2824	Alkylphosphonate utilization operon protein PhnA
CPFRC_RS03765	COG1132	(ABC) transporter
CPFRC_RS03780	COG2354	Protein conserved in bacteria
CPFRC_RS03790	COG4721	ABC-type cobalt transport system, permease component
CPFRC_RS03795	COG1122	ATPase activity
CPFRC_RS03805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPFRC_RS03815	COG4166	transmembrane transport
CPFRC_RS03820	COG0601	transmembrane transport
CPFRC_RS03860	COG4166	transmembrane transport
CPFRC_RS03895	COG1113	amino acid transport
CPFRC_RS03905	COG1113	amino acid transport
CPFRC_RS03915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPFRC_RS03920	COG1611	Belongs to the LOG family
CPFRC_RS03925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPFRC_RS03930	COG0463	Glycosyl transferase, family 2
CPFRC_RS03955	COG3527	Alpha-acetolactate decarboxylase
CPFRC_RS03960	COG0297	glycogen (starch) synthase activity
CPFRC_RS03970	COG4122	O-methyltransferase activity
CPFRC_RS04000	COG2239	Acts as a magnesium transporter
CPFRC_RS04010	COG0567	Dehydrogenase, E1 component
CPFRC_RS04010	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPFRC_RS04015	COG1132	(ABC) transporter
CPFRC_RS04025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPFRC_RS04030	COG2272	Belongs to the type-B carboxylesterase lipase family
CPFRC_RS04050	COG2017	converts alpha-aldose to the beta-anomer
CPFRC_RS04070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CPFRC_RS04100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPFRC_RS04105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CPFRC_RS04130	COG1846	Transcriptional regulator
CPFRC_RS04160	COG1556	Lactate utilization protein
CPFRC_RS04165	COG1139	Iron-sulfur cluster binding protein
CPFRC_RS04170	COG0247	lactate metabolic process
CPFRC_RS04175	COG1620	l-lactate permease
CPFRC_RS04185	COG0019	diaminopimelate decarboxylase activity
CPFRC_RS04190	COG0460	homoserine dehydrogenase
CPFRC_RS04240	COG0356	it plays a direct role in the translocation of protons across the membrane
CPFRC_RS04245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPFRC_RS04250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPFRC_RS04295	COG0346	lactoylglutathione lyase activity
CPFRC_RS04320	COG1119	ATPase activity
CPFRC_RS04340	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CPFRC_RS04405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS04410	COG1120	ATPase activity
CPFRC_RS04420	COG0205	6-phosphofructokinase activity
CPFRC_RS04430	COG0667	Aldo Keto reductase
CPFRC_RS04440	COG0583	DNA-binding transcription factor activity
CPFRC_RS04465	COG0668	transmembrane transport
CPFRC_RS04505	COG0473	3-isopropylmalate dehydrogenase activity
CPFRC_RS04525	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPFRC_RS04610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CPFRC_RS04615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CPFRC_RS04620	COG1461	Dihydroxyacetone kinase
CPFRC_RS04630	COG0511	ligase activity, forming carbon-carbon bonds
CPFRC_RS04635	COG0742	ribosomal rna small subunit methyltransferase
CPFRC_RS04660	COG0765	amino acid transport
CPFRC_RS04685	COG2226	methyltransferase
CPFRC_RS04690	COG0539	negative regulation of cytoplasmic translation
CPFRC_RS04700	COG0237	dephospho-CoA kinase activity
CPFRC_RS04720	COG3973	AAA domain
CPFRC_RS04730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPFRC_RS04745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPFRC_RS04760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPFRC_RS04775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CPFRC_RS04810	COG0165	Argininosuccinate lyase
CPFRC_RS04815	COG2835	tetraacyldisaccharide 4'-kinase activity
CPFRC_RS04850	COG0647	UMP catabolic process
CPFRC_RS04885	COG4974	Belongs to the 'phage' integrase family
CPFRC_RS04905	COG3104	oligopeptide transport
CPFRC_RS04910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CPFRC_RS04920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPFRC_RS04935	COG1160	GTP binding
CPFRC_RS04940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CPFRC_RS04945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CPFRC_RS04950	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPFRC_RS04955	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPFRC_RS04960	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CPFRC_RS04965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS04970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS04975	COG1120	ATPase activity
CPFRC_RS04980	COG4264	IucA IucC family
CPFRC_RS04990	COG3547	Transposase (IS116 IS110 IS902 family)
CPFRC_RS05015	COG3012	SEC-C Motif Domain Protein
CPFRC_RS05025	COG0653	protein targeting
CPFRC_RS05065	COG1253	flavin adenine dinucleotide binding
CPFRC_RS05070	COG0513	Belongs to the DEAD box helicase family
CPFRC_RS05075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CPFRC_RS05085	COG0598	Magnesium transport protein CorA
CPFRC_RS05105	COG0477	Major facilitator Superfamily
CPFRC_RS05130	COG0463	Glycosyl transferase, family 2
CPFRC_RS05180	COG0300	oxidoreductase activity
CPFRC_RS05195	COG0805	protein transport
CPFRC_RS05205	COG2378	regulation of single-species biofilm formation
CPFRC_RS05225	COG4122	O-methyltransferase activity
CPFRC_RS05240	COG1362	aminopeptidase activity
CPFRC_RS05260	COG1027	Aspartate ammonia-lyase
CPFRC_RS05265	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CPFRC_RS05285	COG1410	methionine synthase
CPFRC_RS05285	COG0646	methionine synthase
CPFRC_RS05305	COG0667	Aldo Keto reductase
CPFRC_RS05315	COG0167	dihydroorotate dehydrogenase activity
CPFRC_RS05340	COG1461	Dihydroxyacetone kinase
CPFRC_RS05345	COG2376	Dihydroxyacetone kinase
CPFRC_RS05355	COG3842	ATPase activity
CPFRC_RS05425	COG3883	PFAM NLP P60 protein
CPFRC_RS05425	COG0791	NLP P60 protein
CPFRC_RS05455	COG2848	UPF0210 protein
CPFRC_RS05480	COG2151	metal-sulfur cluster biosynthetic enzyme
CPFRC_RS05485	COG0822	iron-sulfur transferase activity
CPFRC_RS05495	COG0396	ATPase activity
CPFRC_RS05540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPFRC_RS05545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPFRC_RS05565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPFRC_RS05585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPFRC_RS05595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CPFRC_RS05605	COG0322	excinuclease ABC activity
CPFRC_RS05635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPFRC_RS05650	COG0242	peptide deformylase activity
CPFRC_RS05690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPFRC_RS05700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPFRC_RS05715	COG1090	epimerase
CPFRC_RS05740	COG0006	proline dipeptidase activity
CPFRC_RS05745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPFRC_RS05750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CPFRC_RS05755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CPFRC_RS05760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CPFRC_RS05780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPFRC_RS05835	COG1760	l-serine dehydratase
CPFRC_RS05860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPFRC_RS05865	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CPFRC_RS05880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPFRC_RS05895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPFRC_RS05900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPFRC_RS05930	COG1946	Acyl-CoA thioesterase
CPFRC_RS05945	COG0156	8-amino-7-oxononanoate synthase activity
CPFRC_RS05960	COG1560	Kdo2-lipid A biosynthetic process
CPFRC_RS05965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPFRC_RS05980	COG2837	iron assimilation
CPFRC_RS06035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPFRC_RS06125	COG2890	protein-(glutamine-N5) methyltransferase activity
CPFRC_RS06165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPFRC_RS06170	COG0450	alkyl hydroperoxide reductase
CPFRC_RS06185	COG1643	Atp-dependent helicase
CPFRC_RS06205	COG1349	DNA-binding transcription factor activity
CPFRC_RS06210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPFRC_RS06215	COG1349	DNA-binding transcription factor activity
CPFRC_RS06220	COG1105	Belongs to the carbohydrate kinase PfkB family
CPFRC_RS06225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPFRC_RS06225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPFRC_RS06225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CPFRC_RS06235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPFRC_RS06240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPFRC_RS06250	COG2233	PERMEase
CPFRC_RS06255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPFRC_RS06270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CPFRC_RS06285	COG1196	nuclear chromosome segregation
CPFRC_RS06305	COG2137	regulation of response to DNA damage stimulus
CPFRC_RS06310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CPFRC_RS06320	COG1268	BioY protein
CPFRC_RS06325	COG1122	ATPase activity
CPFRC_RS06340	COG1396	sequence-specific DNA binding
CPFRC_RS06365	COG1674	ftsk spoiiie
CPFRC_RS06375	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPFRC_RS06415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPFRC_RS06430	COG0534	Mate efflux family protein
CPFRC_RS06475	COG3022	response to hydroperoxide
CPFRC_RS06480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPFRC_RS06480	COG1648	precorrin-2 dehydrogenase activity
CPFRC_RS06485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CPFRC_RS06490	COG0523	cobalamin synthesis protein
CPFRC_RS06495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPFRC_RS06495	COG2169	Transcriptional regulator
CPFRC_RS06560	COG0750	zinc metalloprotease
CPFRC_RS06615	COG4974	Belongs to the 'phage' integrase family
CPFRC_RS06640	COG0681	Belongs to the peptidase S26 family
CPFRC_RS06655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPFRC_RS06655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPFRC_RS06655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPFRC_RS06665	COG0336	Belongs to the RNA methyltransferase TrmD family
CPFRC_RS06670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CPFRC_RS06690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CPFRC_RS06720	COG1115	amino acid carrier protein
CPFRC_RS06725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPFRC_RS06750	COG0686	Belongs to the AlaDH PNT family
CPFRC_RS06755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPFRC_RS06760	COG1929	Belongs to the glycerate kinase type-1 family
CPFRC_RS06775	COG1473	amidohydrolase
CPFRC_RS06785	COG0058	SHG alpha-glucan phosphorylase activity
CPFRC_RS06795	COG0469	pyruvate kinase activity
CPFRC_RS06805	COG0134	indole-3-glycerol-phosphate synthase activity
CPFRC_RS06825	COG0483	inositol monophosphate 1-phosphatase activity
CPFRC_RS06890	COG2176	DNA-directed DNA polymerase activity
CPFRC_RS06915	COG1739	Uncharacterized protein family UPF0029
CPFRC_RS06920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPFRC_RS06945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CPFRC_RS06960	COG0252	asparaginase activity
CPFRC_RS06980	COG3599	regulation of cell shape
CPFRC_RS06990	COG1799	cell septum assembly
CPFRC_RS07000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CPFRC_RS07010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPFRC_RS07040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPFRC_RS07045	COG0768	penicillin binding
CPFRC_RS07105	COG0515	serine threonine protein kinase
CPFRC_RS07105	COG2815	serine threonine protein kinase
CPFRC_RS07110	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CPFRC_RS07130	COG1940	carbohydrate kinase activity
CPFRC_RS07135	COG0438	transferase activity, transferring glycosyl groups
CPFRC_RS07145	COG0791	NLP P60 protein
CPFRC_RS07195	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CPFRC_RS07200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CPFRC_RS07210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPFRC_RS07230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPFRC_RS07230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPFRC_RS07235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CPFRC_RS07240	COG0509	glycine decarboxylation via glycine cleavage system
CPFRC_RS07270	COG0174	glutamine synthetase
CPFRC_RS07420	COG2056	Na+-H+ antiporter family
CPFRC_RS07430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CPFRC_RS07455	COG0174	glutamine synthetase
CPFRC_RS07480	COG0557	exoribonuclease II activity
CPFRC_RS07500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CPFRC_RS07500	COG3323	Protein of unknown function (DUF1653)
CPFRC_RS07540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CPFRC_RS07545	COG0596	Alpha beta hydrolase
CPFRC_RS07570	COG2860	membrane
CPFRC_RS07640	COG0423	glycine-tRNA ligase activity
CPFRC_RS07670	COG1381	Involved in DNA repair and RecF pathway recombination
CPFRC_RS07725	COG1022	Amp-dependent synthetase and ligase
CPFRC_RS07775	COG1114	Component of the transport system for branched-chain amino acids
CPFRC_RS07780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPFRC_RS07790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPFRC_RS07805	COG0747	negative chemotaxis
CPFRC_RS07810	COG0601	transmembrane transport
CPFRC_RS07815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPFRC_RS07820	COG4172	Belongs to the ABC transporter superfamily
CPFRC_RS07830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPFRC_RS07835	COG2391	methyltransferase activity
CPFRC_RS07845	COG0601	transmembrane transport
CPFRC_RS07865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPFRC_RS07870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPFRC_RS07895	COG1280	lysine exporter protein (LysE YggA)
CPFRC_RS07920	COG1307	EDD domain protein, DegV family
CPFRC_RS07925	COG0406	alpha-ribazole phosphatase activity
CPFRC_RS07935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPFRC_RS07950	COG2832	Protein of unknown function (DUF454)
CPFRC_RS07955	COG2985	domain, Protein
CPFRC_RS07955	COG0569	domain protein
CPFRC_RS07980	COG1530	ribonuclease E activity
CPFRC_RS07995	COG2423	ornithine cyclodeaminase activity
CPFRC_RS08005	COG0285	dihydrofolate synthase activity
CPFRC_RS08045	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPFRC_RS08080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CPFRC_RS08090	COG0668	transmembrane transport
CPFRC_RS08170	COG1131	(ABC) transporter
CPFRC_RS08175	COG3336	cytochrome c oxidase
CPFRC_RS08180	COG1966	Carbon starvation protein
CPFRC_RS08200	COG0604	alcohol dehydrogenase
CPFRC_RS08205	COG4221	oxidoreductase activity
CPFRC_RS08225	COG1376	ErfK ybiS ycfS ynhG family protein
CPFRC_RS08235	COG2130	NADP-dependent
CPFRC_RS08240	COG1335	isochorismatase
CPFRC_RS08285	COG2197	response regulator
CPFRC_RS08335	COG1234	tRNA 3'-trailer cleavage
CPFRC_RS08360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPFRC_RS08405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPFRC_RS08415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPFRC_RS08435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CPFRC_RS08500	COG0033	Phosphoglucomutase
CPFRC_RS08515	COG1136	(ABC) transporter
CPFRC_RS08515	COG0577	efflux transmembrane transporter activity
CPFRC_RS08520	COG0577	efflux transmembrane transporter activity
CPFRC_RS08520	COG1136	(ABC) transporter
CPFRC_RS08555	COG2197	response regulator
CPFRC_RS08570	COG1045	serine acetyltransferase
CPFRC_RS08590	COG0371	Dehydrogenase
CPFRC_RS08610	COG1271	oxidase subunit
CPFRC_RS08615	COG1294	oxidase, subunit
CPFRC_RS08620	COG4988	ABC transporter
CPFRC_RS08625	COG4988	ABC transporter
CPFRC_RS08650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPFRC_RS08680	COG1597	lipid kinase activity
CPFRC_RS08695	COG0354	folic acid binding
CPFRC_RS08720	COG1780	Probably involved in ribonucleotide reductase function
CPFRC_RS08725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPFRC_RS08735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPFRC_RS08740	COG0047	phosphoribosylformylglycinamidine synthase activity
CPFRC_RS08745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPFRC_RS08750	COG0386	Belongs to the glutathione peroxidase family
CPFRC_RS08770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPFRC_RS08775	COG0569	domain protein
CPFRC_RS08780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPFRC_RS08785	COG0151	Belongs to the GarS family
CPFRC_RS08790	COG0537	adenosine 5'-monophosphoramidase activity
CPFRC_RS08800	COG2205	protein histidine kinase activity
CPFRC_RS08805	COG0745	RESPONSE REGULATOR receiver
CPFRC_RS08835	COG0028	Belongs to the TPP enzyme family
CPFRC_RS08880	COG1609	Transcriptional regulator
CPFRC_RS08890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPFRC_RS08910	COG1329	Transcriptional regulator
CPFRC_RS08915	COG2847	Copper chaperone PCu(A)C
CPFRC_RS08930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPFRC_RS08940	COG0288	reversible hydration of carbon dioxide
CPFRC_RS08960	COG0542	response to heat
CPFRC_RS08970	COG0477	Major facilitator Superfamily
CPFRC_RS08975	COG1957	nucleoside hydrolase
CPFRC_RS08990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPFRC_RS09005	COG1301	dicarboxylic acid transport
CPFRC_RS09010	COG1012	belongs to the aldehyde dehydrogenase family
CPFRC_RS09015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPFRC_RS09020	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CPFRC_RS09025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPFRC_RS09055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPFRC_RS09060	COG0302	gtp cyclohydrolase
CPFRC_RS09065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPFRC_RS09080	COG2027	D-alanyl-D-alanine carboxypeptidase
CPFRC_RS09085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CPFRC_RS09090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPFRC_RS09090	COG0425	Belongs to the sulfur carrier protein TusA family
CPFRC_RS09095	COG1301	dicarboxylic acid transport
CPFRC_RS09115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CPFRC_RS09120	COG2326	polyphosphate kinase activity
CPFRC_RS09140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPFRC_RS09160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPFRC_RS09160	COG2111	Na H antiporter
CPFRC_RS09190	COG1051	belongs to the nudix hydrolase family
CPFRC_RS09210	COG0242	peptide deformylase activity
CPFRC_RS09215	COG0456	acetyltransferase
CPFRC_RS09225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPFRC_RS09250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPFRC_RS09265	COG0280	phosphate acetyltransferase
CPFRC_RS09285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CPFRC_RS09290	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CPFRC_RS09320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPFRC_RS09325	COG1333	cytochrome c biogenesis protein
CPFRC_RS09335	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CPFRC_RS09340	COG3005	denitrification pathway
CPFRC_RS09355	COG4129	membrane
CPFRC_RS09400	COG0191	fructose-bisphosphate aldolase activity
CPFRC_RS09415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CPFRC_RS09430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CPFRC_RS09470	COG1131	(ABC) transporter
CPFRC_RS09500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPFRC_RS09510	COG1136	(ABC) transporter
CPFRC_RS09510	COG0577	efflux transmembrane transporter activity
CPFRC_RS09515	COG1136	(ABC) transporter
CPFRC_RS09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPFRC_RS09560	COG0789	Transcriptional regulator
CPFRC_RS09575	COG0443	Heat shock 70 kDa protein
CPFRC_RS09610	COG0601	transmembrane transport
CPFRC_RS09630	COG2181	nitrate reductase activity
CPFRC_RS09630	COG0247	lactate metabolic process
CPFRC_RS09645	COG1120	ATPase activity
CPFRC_RS09650	COG4139	cobalamin transport
CPFRC_RS09660	COG0829	nickel cation binding
CPFRC_RS09665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CPFRC_RS09670	COG0830	nickel cation binding
CPFRC_RS09675	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CPFRC_RS09680	COG0804	urea catabolic process
CPFRC_RS09685	COG0832	Belongs to the urease beta subunit family
CPFRC_RS09690	COG0831	urea catabolic process
CPFRC_RS09715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPFRC_RS09715	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPFRC_RS09735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CPFRC_RS09750	COG1012	belongs to the aldehyde dehydrogenase family
CPFRC_RS09760	COG1472	Belongs to the glycosyl hydrolase 3 family
CPFRC_RS09770	COG4981	capsule polysaccharide biosynthetic process
CPFRC_RS09775	COG2755	lipolytic protein G-D-S-L family
CPFRC_RS09775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPFRC_RS09790	COG0438	transferase activity, transferring glycosyl groups
CPFRC_RS09795	COG0500	methyltransferase
CPFRC_RS09840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPFRC_RS09845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CPFRC_RS09845	COG3321	synthase
CPFRC_RS09850	COG0318	PFAM AMP-dependent synthetase and ligase
CPFRC_RS09865	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPFRC_RS09865	COG5479	isomerase activity
CPFRC_RS09880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CPFRC_RS09885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CPFRC_RS09890	COG0671	phosphoesterase, PA-phosphatase related
CPFRC_RS09895	COG1216	Glycosyl transferase, family 2
CPFRC_RS09905	COG0671	phosphoesterase, PA-phosphatase related
CPFRC_RS09915	COG0584	glycerophosphoryl diester phosphodiesterase
CPFRC_RS09920	COG2271	Major facilitator Superfamily
CPFRC_RS09935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPFRC_RS09940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPFRC_RS09950	COG0561	phosphatase activity
CPFRC_RS09965	COG2188	Transcriptional regulator
CPFRC_RS09990	COG0154	amidase activity
CPFRC_RS10000	COG1316	TRANSCRIPTIONal
CPFRC_RS10030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPFRC_RS10060	COG0431	NADPH-dependent FMN reductase
CPFRC_RS10065	COG2814	Major facilitator Superfamily
CPFRC_RS10085	COG5650	phosphatidylinositol metabolic process
CPFRC_RS10105	COG2197	response regulator
CPFRC_RS10120	COG3764	Sortase (surface protein transpeptidase)
CPFRC_RS10125	COG0706	membrane insertase activity
CPFRC_RS10150	COG0564	pseudouridine synthase activity
CPFRC_RS10180	COG1131	(ABC) transporter
CPFRC_RS10200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPFRC_RS10215	COG0477	Major facilitator Superfamily
CPFRC_RS10220	COG0305	Participates in initiation and elongation during chromosome replication
CPFRC_RS10225	COG3387	PFAM Glycoside hydrolase 15-related
CPFRC_RS10240	COG0629	single-stranded DNA binding
CPFRC_RS10265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPFRC_RS10285	COG0300	oxidoreductase activity
CPFRC_RS10300	COG0586	Pfam SNARE associated Golgi protein
CPFRC_RS10305	COG0783	Belongs to the Dps family
CPFRC_RS10310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPFRC_RS10315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPFRC_RS10315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CPFRC_RS10325	COG1511	domain protein
CPFRC_RS10335	COG0577	efflux transmembrane transporter activity
CPFRC_RS10335	COG1136	(ABC) transporter
CPFRC_RS10355	COG4585	Histidine kinase
CPFRC_RS10360	COG2197	response regulator
CPFRC_RS10375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CPFRC_RS10390	COG2186	Transcriptional regulator
CPFRC_RS10395	COG0747	negative chemotaxis
CPFRC_RS10400	COG0601	transmembrane transport
CPFRC_RS10405	COG0444	Belongs to the ABC transporter superfamily
CPFRC_RS10410	COG4608	Belongs to the ABC transporter superfamily
CPFRC_RS10415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPFRC_RS10455	COG3422	double-strand break repair
CPFRC_RS10470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CPFRC_RS10490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CPFRC_RS10495	COG0512	Glutamine amidotransferase of anthranilate synthase
CPFRC_RS10505	COG0134	indole-3-glycerol-phosphate synthase activity
CPFRC_RS10505	COG0135	phosphoribosylanthranilate isomerase activity
CPFRC_RS10535	COG1687	branched-chain amino acid
CPFRC_RS10540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CPFRC_RS10545	COG1678	Uncharacterized ACR, COG1678
CPFRC_RS10550	COG0617	tRNA 3'-terminal CCA addition
CPFRC_RS10585	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPFRC_RS10585	COG3409	Peptidoglycan-binding domain 1 protein
CPFRC_RS10600	COG1192	Involved in chromosome partitioning
CPFRC_RS10615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPFRC_RS10625	COG0230	Belongs to the bacterial ribosomal protein bL34 family