locus-tag	class	description
CPTC_RS00020	COG2197	response regulator
CPTC_RS00070	COG1234	tRNA 3'-trailer cleavage
CPTC_RS00095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPTC_RS00140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPTC_RS00150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPTC_RS00170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CPTC_RS00235	COG0033	Phosphoglucomutase
CPTC_RS00250	COG1136	(ABC) transporter
CPTC_RS00250	COG0577	efflux transmembrane transporter activity
CPTC_RS00255	COG1136	(ABC) transporter
CPTC_RS00255	COG0577	efflux transmembrane transporter activity
CPTC_RS00295	COG0288	reversible hydration of carbon dioxide
CPTC_RS00305	COG2177	Part of the ABC transporter FtsEX involved in
CPTC_RS00310	COG2884	Cell division ATP-binding protein ftsE
CPTC_RS00315	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CPTC_RS00330	COG0483	inositol monophosphate 1-phosphatase activity
CPTC_RS00335	COG0483	inositol monophosphate 1-phosphatase activity
CPTC_RS00450	COG3480	Lon protease (S16) C-terminal proteolytic domain
CPTC_RS00475	COG2816	NAD+ diphosphatase activity
CPTC_RS00485	COG0210	DNA helicase
CPTC_RS00510	COG0513	Belongs to the DEAD box helicase family
CPTC_RS00545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPTC_RS00550	COG2135	peptidase activity
CPTC_RS00555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CPTC_RS00595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CPTC_RS00610	COG5002	protein histidine kinase activity
CPTC_RS00615	COG0745	RESPONSE REGULATOR receiver
CPTC_RS00640	COG1482	cell wall glycoprotein biosynthetic process
CPTC_RS00670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CPTC_RS00680	COG1316	TRANSCRIPTIONal
CPTC_RS00730	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CPTC_RS00730	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CPTC_RS00735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPTC_RS00740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPTC_RS00750	COG1609	Transcriptional regulator
CPTC_RS00755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPTC_RS00760	COG0424	maF-like protein
CPTC_RS00770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPTC_RS00770	COG2755	lipolytic protein G-D-S-L family
CPTC_RS00775	COG0189	ligase activity
CPTC_RS00780	COG2897	thiosulfate sulfurtransferase activity
CPTC_RS00785	COG4770	biotin carboxylase activity
CPTC_RS00795	COG2814	Major facilitator Superfamily
CPTC_RS00810	COG1473	amidohydrolase
CPTC_RS00810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CPTC_RS00815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPTC_RS00850	COG1686	Belongs to the peptidase S11 family
CPTC_RS00855	COG1295	ribonuclease BN
CPTC_RS00860	COG0180	Tryptophanyl-tRNA synthetase
CPTC_RS00875	COG0789	Transcriptional regulator
CPTC_RS00875	COG4978	Transcriptional regulator
CPTC_RS00880	COG2814	Major facilitator Superfamily
CPTC_RS00885	COG2838	Isocitrate dehydrogenase
CPTC_RS00900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CPTC_RS00905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS00940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CPTC_RS00945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CPTC_RS00950	COG1321	iron dependent repressor
CPTC_RS00955	COG1321	iron dependent repressor
CPTC_RS00955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPTC_RS00965	COG1121	(ABC) transporter
CPTC_RS00970	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPTC_RS00990	COG1464	Belongs to the NlpA lipoprotein family
CPTC_RS00995	COG1464	Belongs to the NlpA lipoprotein family
CPTC_RS01005	COG2011	ABC-type metal ion transport system permease component
CPTC_RS01050	COG0516	GMP reductase activity
CPTC_RS01120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPTC_RS01175	COG1674	ftsk spoiiie
CPTC_RS01185	COG1404	Belongs to the peptidase S8 family
CPTC_RS01205	COG0203	ribosomal protein L17
CPTC_RS01260	COG0201	protein transport
CPTC_RS01265	COG3842	ATPase activity
CPTC_RS01285	COG3833	ABC-type maltose transport systems, permease component
CPTC_RS01290	COG1175	transmembrane transport
CPTC_RS01335	COG0671	phosphoesterase, PA-phosphatase related
CPTC_RS01340	COG0252	asparaginase activity
CPTC_RS01345	COG1760	l-serine dehydratase
CPTC_RS01350	COG0814	amino acid
CPTC_RS01445	COG1302	Protein conserved in bacteria
CPTC_RS01515	COG0701	Predicted permease
CPTC_RS01530	COG1131	(ABC) transporter
CPTC_RS01570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPTC_RS01575	COG1121	(ABC) transporter
CPTC_RS01585	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPTC_RS01605	COG1902	pentaerythritol trinitrate reductase activity
CPTC_RS01610	COG3579	cysteine-type endopeptidase activity
CPTC_RS01635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPTC_RS01660	COG0142	geranyltranstransferase activity
CPTC_RS01665	COG0644	oxidoreductase
CPTC_RS01670	COG0039	L-malate dehydrogenase activity
CPTC_RS01680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPTC_RS01680	COG0438	transferase activity, transferring glycosyl groups
CPTC_RS01695	COG4948	Mandelate Racemase Muconate Lactonizing
CPTC_RS01700	COG3069	C4-dicarboxylate transmembrane transporter activity
CPTC_RS01730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPTC_RS01735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS01750	COG0275	rRNA processing
CPTC_RS01760	COG0785	Cytochrome C biogenesis protein
CPTC_RS01770	COG0406	alpha-ribazole phosphatase activity
CPTC_RS01785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CPTC_RS01795	COG2217	Heavy metal translocating P-type atpase
CPTC_RS01810	COG1648	precorrin-2 dehydrogenase activity
CPTC_RS01810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPTC_RS01840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CPTC_RS01840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPTC_RS01850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPTC_RS01870	COG0745	RESPONSE REGULATOR receiver
CPTC_RS01875	COG5002	protein histidine kinase activity
CPTC_RS01890	COG0318	PFAM AMP-dependent synthetase and ligase
CPTC_RS01910	COG1882	Formate acetyltransferase
CPTC_RS01930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CPTC_RS01940	COG2733	membrane
CPTC_RS01950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CPTC_RS01955	COG1053	succinate dehydrogenase
CPTC_RS01965	COG1396	sequence-specific DNA binding
CPTC_RS01965	COG3800	Transcriptional regulator
CPTC_RS01970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPTC_RS01980	COG1505	serine-type exopeptidase activity
CPTC_RS01990	COG1088	dTDP-glucose 4,6-dehydratase activity
CPTC_RS02000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CPTC_RS02010	COG0318	PFAM AMP-dependent synthetase and ligase
CPTC_RS02025	COG0470	DNA polymerase III
CPTC_RS02035	COG1297	OPT oligopeptide transporter protein
CPTC_RS02040	COG1754	DNA topoisomerase type I activity
CPTC_RS02040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPTC_RS02050	COG1205	dead DEAH box helicase
CPTC_RS02050	COG1111	helicase
CPTC_RS02115	COG0494	nUDIX hydrolase
CPTC_RS02135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPTC_RS02155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPTC_RS02210	COG2111	Na H antiporter
CPTC_RS02210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPTC_RS02220	COG0651	ATP synthesis coupled electron transport
CPTC_RS02240	COG3852	Histidine kinase
CPTC_RS02250	COG2271	Major facilitator Superfamily
CPTC_RS02255	COG1840	ABC-type Fe3 transport system, periplasmic component
CPTC_RS02315	COG0527	aspartate kinase activity
CPTC_RS02320	COG0697	spore germination
CPTC_RS02350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPTC_RS02365	COG0813	purine-nucleoside phosphorylase activity
CPTC_RS02370	COG2390	Transcriptional regulator
CPTC_RS02375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPTC_RS02390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPTC_RS02395	COG3442	glutamine amidotransferase
CPTC_RS02400	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPTC_RS02415	COG2084	Dehydrogenase
CPTC_RS02420	COG2610	gluconate transmembrane transporter activity
CPTC_RS02445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPTC_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
CPTC_RS02460	COG1063	alcohol dehydrogenase
CPTC_RS02465	COG3265	gluconokinase activity
CPTC_RS02470	COG2610	gluconate transmembrane transporter activity
CPTC_RS02480	COG0343	queuine tRNA-ribosyltransferase activity
CPTC_RS02485	COG2409	Drug exporters of the RND superfamily
CPTC_RS02505	COG0287	Prephenate dehydrogenase
CPTC_RS02520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPTC_RS02545	COG1263	PTS System
CPTC_RS02545	COG2190	(PTS) system
CPTC_RS02545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPTC_RS02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPTC_RS02550	COG1263	PTS System
CPTC_RS02565	COG0471	metal ion transport
CPTC_RS02590	COG0604	alcohol dehydrogenase
CPTC_RS02615	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPTC_RS02620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPTC_RS02625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPTC_RS02630	COG1121	(ABC) transporter
CPTC_RS02635	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPTC_RS02645	COG1216	Glycosyl transferase, family 2
CPTC_RS02675	COG0277	FAD linked oxidase domain protein
CPTC_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
CPTC_RS02710	COG3590	peptidase
CPTC_RS02720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPTC_RS02725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPTC_RS02750	COG2501	S4 domain
CPTC_RS02755	COG0393	Putative heavy-metal-binding
CPTC_RS02765	COG0519	Catalyzes the synthesis of GMP from XMP
CPTC_RS02775	COG1643	Atp-dependent helicase
CPTC_RS02790	COG0730	response to heat
CPTC_RS02800	COG3180	Ammonia monooxygenase
CPTC_RS02815	COG1846	Transcriptional regulator
CPTC_RS02840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CPTC_RS02865	COG3409	Peptidoglycan-binding domain 1 protein
CPTC_RS02865	COG3757	hydrolase, family 25
CPTC_RS02875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPTC_RS02895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPTC_RS02900	COG0517	IMP dehydrogenase activity
CPTC_RS02900	COG1125	glycine betaine transport
CPTC_RS02955	COG0366	Alpha amylase catalytic
CPTC_RS02960	COG2239	Acts as a magnesium transporter
CPTC_RS02965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS02970	COG1120	ATPase activity
CPTC_RS03000	COG1716	ATPase activity
CPTC_RS03000	COG1716	ATPase activity
CPTC_RS03020	COG0768	penicillin binding
CPTC_RS03025	COG0515	serine threonine protein kinase
CPTC_RS03030	COG2815	serine threonine protein kinase
CPTC_RS03030	COG0515	serine threonine protein kinase
CPTC_RS03040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPTC_RS03045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS03050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS03055	COG1120	ATPase activity
CPTC_RS03145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPTC_RS03165	COG0187	DNA topoisomerase II activity
CPTC_RS03180	COG0592	DNA-directed DNA polymerase activity
CPTC_RS03190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CPTC_RS03200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPTC_RS03215	COG1192	Involved in chromosome partitioning
CPTC_RS03230	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPTC_RS03230	COG3409	Peptidoglycan-binding domain 1 protein
CPTC_RS03265	COG0617	tRNA 3'-terminal CCA addition
CPTC_RS03270	COG1678	Uncharacterized ACR, COG1678
CPTC_RS03275	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CPTC_RS03280	COG1687	branched-chain amino acid
CPTC_RS03315	COG0135	phosphoribosylanthranilate isomerase activity
CPTC_RS03315	COG0134	indole-3-glycerol-phosphate synthase activity
CPTC_RS03325	COG0512	Glutamine amidotransferase of anthranilate synthase
CPTC_RS03330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CPTC_RS03350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CPTC_RS03365	COG3422	double-strand break repair
CPTC_RS03405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPTC_RS03410	COG4608	Belongs to the ABC transporter superfamily
CPTC_RS03415	COG0444	Belongs to the ABC transporter superfamily
CPTC_RS03420	COG0601	transmembrane transport
CPTC_RS03425	COG0747	negative chemotaxis
CPTC_RS03430	COG2186	Transcriptional regulator
CPTC_RS03445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CPTC_RS03460	COG2197	response regulator
CPTC_RS03485	COG1136	(ABC) transporter
CPTC_RS03485	COG0577	efflux transmembrane transporter activity
CPTC_RS03495	COG1511	domain protein
CPTC_RS03505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPTC_RS03505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CPTC_RS03510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPTC_RS03515	COG0783	Belongs to the Dps family
CPTC_RS03520	COG0586	Pfam SNARE associated Golgi protein
CPTC_RS03535	COG0300	oxidoreductase activity
CPTC_RS03555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPTC_RS03575	COG0629	single-stranded DNA binding
CPTC_RS03585	COG3387	PFAM Glycoside hydrolase 15-related
CPTC_RS03590	COG0305	Participates in initiation and elongation during chromosome replication
CPTC_RS03610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPTC_RS03615	COG1842	Phage shock protein A
CPTC_RS03630	COG1131	(ABC) transporter
CPTC_RS03655	COG0564	pseudouridine synthase activity
CPTC_RS03680	COG0706	membrane insertase activity
CPTC_RS03685	COG3764	Sortase (surface protein transpeptidase)
CPTC_RS03705	COG2197	response regulator
CPTC_RS03725	COG5650	phosphatidylinositol metabolic process
CPTC_RS03740	COG2271	Major facilitator Superfamily
CPTC_RS03750	COG2814	Major facilitator Superfamily
CPTC_RS03755	COG0431	NADPH-dependent FMN reductase
CPTC_RS03785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPTC_RS03815	COG1316	TRANSCRIPTIONal
CPTC_RS03830	COG0077	Prephenate dehydratase
CPTC_RS03850	COG2188	Transcriptional regulator
CPTC_RS03865	COG0561	phosphatase activity
CPTC_RS03875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPTC_RS03880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS03895	COG2271	Major facilitator Superfamily
CPTC_RS03900	COG0584	glycerophosphoryl diester phosphodiesterase
CPTC_RS03910	COG0671	phosphoesterase, PA-phosphatase related
CPTC_RS03920	COG1216	Glycosyl transferase, family 2
CPTC_RS03925	COG0671	phosphoesterase, PA-phosphatase related
CPTC_RS03930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CPTC_RS03935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CPTC_RS03950	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPTC_RS03950	COG5479	isomerase activity
CPTC_RS03960	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CPTC_RS03965	COG0318	PFAM AMP-dependent synthetase and ligase
CPTC_RS03970	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CPTC_RS03970	COG3321	synthase
CPTC_RS03970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPTC_RS03975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPTC_RS04020	COG0500	methyltransferase
CPTC_RS04025	COG0438	transferase activity, transferring glycosyl groups
CPTC_RS04045	COG2755	lipolytic protein G-D-S-L family
CPTC_RS04045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPTC_RS04050	COG4981	capsule polysaccharide biosynthetic process
CPTC_RS04060	COG1472	Belongs to the glycosyl hydrolase 3 family
CPTC_RS04085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CPTC_RS04105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPTC_RS04105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPTC_RS04125	COG0831	urea catabolic process
CPTC_RS04130	COG0832	Belongs to the urease beta subunit family
CPTC_RS04135	COG0804	urea catabolic process
CPTC_RS04140	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CPTC_RS04145	COG0830	nickel cation binding
CPTC_RS04150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CPTC_RS04155	COG0829	nickel cation binding
CPTC_RS04165	COG4139	cobalamin transport
CPTC_RS04170	COG1120	ATPase activity
CPTC_RS04185	COG2181	nitrate reductase activity
CPTC_RS04185	COG0247	lactate metabolic process
CPTC_RS04205	COG0601	transmembrane transport
CPTC_RS04240	COG0443	Heat shock 70 kDa protein
CPTC_RS04255	COG0789	Transcriptional regulator
CPTC_RS04295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPTC_RS04300	COG1136	(ABC) transporter
CPTC_RS04305	COG1136	(ABC) transporter
CPTC_RS04305	COG0577	efflux transmembrane transporter activity
CPTC_RS04325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPTC_RS04355	COG1131	(ABC) transporter
CPTC_RS04395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CPTC_RS04410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CPTC_RS04425	COG0191	fructose-bisphosphate aldolase activity
CPTC_RS04470	COG4129	membrane
CPTC_RS04485	COG3005	denitrification pathway
CPTC_RS04490	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CPTC_RS04500	COG1333	cytochrome c biogenesis protein
CPTC_RS04505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPTC_RS04535	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CPTC_RS04540	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CPTC_RS04560	COG0280	phosphate acetyltransferase
CPTC_RS04575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPTC_RS04600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPTC_RS04610	COG0456	acetyltransferase
CPTC_RS04615	COG0242	peptide deformylase activity
CPTC_RS04635	COG1051	belongs to the nudix hydrolase family
CPTC_RS04655	COG0651	ATP synthesis coupled electron transport
CPTC_RS04660	COG1006	Multisubunit Na H antiporter MnhC subunit
CPTC_RS04665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPTC_RS04665	COG2111	Na H antiporter
CPTC_RS04705	COG2326	polyphosphate kinase activity
CPTC_RS04710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CPTC_RS04725	COG1301	dicarboxylic acid transport
CPTC_RS04730	COG0425	Belongs to the sulfur carrier protein TusA family
CPTC_RS04730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPTC_RS04735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CPTC_RS04740	COG2027	D-alanyl-D-alanine carboxypeptidase
CPTC_RS04750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CPTC_RS04755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPTC_RS04760	COG0302	gtp cyclohydrolase
CPTC_RS04765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPTC_RS04795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPTC_RS04800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CPTC_RS04805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPTC_RS04810	COG1012	belongs to the aldehyde dehydrogenase family
CPTC_RS04815	COG1301	dicarboxylic acid transport
CPTC_RS04830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPTC_RS04845	COG1957	nucleoside hydrolase
CPTC_RS04850	COG0477	Major facilitator Superfamily
CPTC_RS04860	COG0542	response to heat
CPTC_RS04875	COG0288	reversible hydration of carbon dioxide
CPTC_RS04885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPTC_RS04900	COG2847	Copper chaperone PCu(A)C
CPTC_RS04905	COG1329	Transcriptional regulator
CPTC_RS04925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPTC_RS04935	COG1609	Transcriptional regulator
CPTC_RS04975	COG0028	Belongs to the TPP enzyme family
CPTC_RS05005	COG0745	RESPONSE REGULATOR receiver
CPTC_RS05010	COG2205	protein histidine kinase activity
CPTC_RS05020	COG0537	adenosine 5'-monophosphoramidase activity
CPTC_RS05025	COG0151	Belongs to the GarS family
CPTC_RS05030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPTC_RS05035	COG0569	domain protein
CPTC_RS05040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPTC_RS05060	COG0386	Belongs to the glutathione peroxidase family
CPTC_RS05065	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPTC_RS05070	COG0047	phosphoribosylformylglycinamidine synthase activity
CPTC_RS05075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPTC_RS05085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPTC_RS05090	COG1780	Probably involved in ribonucleotide reductase function
CPTC_RS05115	COG0354	folic acid binding
CPTC_RS05130	COG1597	lipid kinase activity
CPTC_RS05160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPTC_RS05185	COG1132	(ABC) transporter
CPTC_RS05190	COG4988	ABC transporter
CPTC_RS05195	COG1294	oxidase, subunit
CPTC_RS05200	COG1271	oxidase subunit
CPTC_RS05220	COG0371	Dehydrogenase
CPTC_RS05240	COG1045	serine acetyltransferase
CPTC_RS05255	COG2197	response regulator
CPTC_RS05295	COG1061	Type III restriction enzyme res subunit
CPTC_RS05310	COG1652	LysM domain
CPTC_RS05335	COG2252	PERMEase
CPTC_RS05340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPTC_RS05360	COG0372	Belongs to the citrate synthase family
CPTC_RS05365	COG0545	Peptidyl-prolyl cis-trans isomerase
CPTC_RS05380	COG0656	L-ascorbic acid biosynthetic process
CPTC_RS05385	COG1024	Enoyl-CoA hydratase
CPTC_RS05395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPTC_RS05405	COG3757	hydrolase, family 25
CPTC_RS05420	COG0534	Mate efflux family protein
CPTC_RS05425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPTC_RS05430	COG0019	diaminopimelate decarboxylase activity
CPTC_RS05460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPTC_RS05480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CPTC_RS05500	COG1201	RNA secondary structure unwinding
CPTC_RS05510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPTC_RS05560	COG1126	abc transporter atp-binding protein
CPTC_RS05565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPTC_RS05570	COG0765	amino acid transport
CPTC_RS05575	COG0765	amino acid transport
CPTC_RS05585	COG1309	transcriptional regulator
CPTC_RS05615	COG0254	rRNA binding
CPTC_RS05625	COG0745	RESPONSE REGULATOR receiver
CPTC_RS05630	COG2205	protein histidine kinase activity
CPTC_RS05635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPTC_RS05640	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPTC_RS05640	COG0315	cyclic pyranopterin monophosphate synthase activity
CPTC_RS05660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CPTC_RS05680	COG2259	Doxx family
CPTC_RS05690	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CPTC_RS05695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPTC_RS05700	COG3949	Membrane
CPTC_RS05715	COG0084	hydrolase, TatD family'
CPTC_RS05720	COG3583	domain protein
CPTC_RS05735	COG0488	(ABC) transporter
CPTC_RS05750	COG2326	polyphosphate kinase activity
CPTC_RS05785	COG0596	Alpha beta hydrolase
CPTC_RS05790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPTC_RS05800	COG0193	aminoacyl-tRNA hydrolase activity
CPTC_RS05805	COG2070	2-Nitropropane dioxygenase
CPTC_RS05825	COG1523	belongs to the glycosyl hydrolase 13 family
CPTC_RS05830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPTC_RS05835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPTC_RS05840	COG2132	Multicopper oxidase
CPTC_RS05855	COG1309	transcriptional regulator
CPTC_RS05865	COG0531	amino acid
CPTC_RS05870	COG3956	TIGRFAM MazG family protein
CPTC_RS05930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CPTC_RS06000	COG0114	fumarate hydratase activity
CPTC_RS06005	COG1494	fructose-1,6-bisphosphatase
CPTC_RS06040	COG0012	GTP binding
CPTC_RS06055	COG2824	Alkylphosphonate utilization operon protein PhnA
CPTC_RS06060	COG1132	(ABC) transporter
CPTC_RS06070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPTC_RS06075	COG2354	Protein conserved in bacteria
CPTC_RS06085	COG4721	ABC-type cobalt transport system, permease component
CPTC_RS06090	COG1122	ATPase activity
CPTC_RS06100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPTC_RS06110	COG4166	transmembrane transport
CPTC_RS06115	COG0601	transmembrane transport
CPTC_RS06120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPTC_RS06150	COG1217	gtp-binding protein TYPA
CPTC_RS06155	COG4166	transmembrane transport
CPTC_RS06190	COG1113	amino acid transport
CPTC_RS06200	COG1113	amino acid transport
CPTC_RS06210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPTC_RS06215	COG1611	Belongs to the LOG family
CPTC_RS06220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPTC_RS06225	COG0463	Glycosyl transferase, family 2
CPTC_RS06245	COG3527	Alpha-acetolactate decarboxylase
CPTC_RS06250	COG0297	glycogen (starch) synthase activity
CPTC_RS06260	COG4122	O-methyltransferase activity
CPTC_RS06290	COG2239	Acts as a magnesium transporter
CPTC_RS06300	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPTC_RS06300	COG0567	Dehydrogenase, E1 component
CPTC_RS06305	COG1132	(ABC) transporter
CPTC_RS06315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPTC_RS06320	COG2272	Belongs to the type-B carboxylesterase lipase family
CPTC_RS06335	COG2017	converts alpha-aldose to the beta-anomer
CPTC_RS06355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CPTC_RS06385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPTC_RS06390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CPTC_RS06415	COG1846	Transcriptional regulator
CPTC_RS06445	COG1556	Lactate utilization protein
CPTC_RS06450	COG1139	Iron-sulfur cluster binding protein
CPTC_RS06455	COG0247	lactate metabolic process
CPTC_RS06460	COG1620	l-lactate permease
CPTC_RS06470	COG0019	diaminopimelate decarboxylase activity
CPTC_RS06475	COG0460	homoserine dehydrogenase
CPTC_RS06525	COG0356	it plays a direct role in the translocation of protons across the membrane
CPTC_RS06530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPTC_RS06535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPTC_RS06575	COG0346	lactoylglutathione lyase activity
CPTC_RS06600	COG1119	ATPase activity
CPTC_RS06620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CPTC_RS06690	COG1120	ATPase activity
CPTC_RS06700	COG0205	6-phosphofructokinase activity
CPTC_RS06710	COG0667	Aldo Keto reductase
CPTC_RS06720	COG0583	DNA-binding transcription factor activity
CPTC_RS06745	COG0668	transmembrane transport
CPTC_RS06785	COG0473	3-isopropylmalate dehydrogenase activity
CPTC_RS06805	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPTC_RS06835	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CPTC_RS06870	COG0406	alpha-ribazole phosphatase activity
CPTC_RS06870	COG0494	nUDIX hydrolase
CPTC_RS06890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CPTC_RS06895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CPTC_RS06900	COG1461	Dihydroxyacetone kinase
CPTC_RS06910	COG0511	ligase activity, forming carbon-carbon bonds
CPTC_RS06915	COG0742	ribosomal rna small subunit methyltransferase
CPTC_RS06940	COG0765	amino acid transport
CPTC_RS06965	COG2226	methyltransferase
CPTC_RS06970	COG0539	negative regulation of cytoplasmic translation
CPTC_RS06980	COG0237	dephospho-CoA kinase activity
CPTC_RS07000	COG3973	AAA domain
CPTC_RS07010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPTC_RS07025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPTC_RS07040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPTC_RS07055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CPTC_RS07070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CPTC_RS07090	COG0165	Argininosuccinate lyase
CPTC_RS07095	COG2835	tetraacyldisaccharide 4'-kinase activity
CPTC_RS07125	COG0647	UMP catabolic process
CPTC_RS07155	COG0494	nUDIX hydrolase
CPTC_RS07160	COG4974	Belongs to the 'phage' integrase family
CPTC_RS07180	COG3104	oligopeptide transport
CPTC_RS07185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CPTC_RS07195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPTC_RS07210	COG1160	GTP binding
CPTC_RS07215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CPTC_RS07220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CPTC_RS07225	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPTC_RS07230	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPTC_RS07235	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CPTC_RS07240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS07245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPTC_RS07250	COG1120	ATPase activity
CPTC_RS07255	COG4264	IucA IucC family
CPTC_RS07285	COG0653	protein targeting
CPTC_RS07325	COG1253	flavin adenine dinucleotide binding
CPTC_RS07330	COG0513	Belongs to the DEAD box helicase family
CPTC_RS07335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CPTC_RS07345	COG0598	Magnesium transport protein CorA
CPTC_RS07365	COG0477	Major facilitator Superfamily
CPTC_RS07385	COG0463	Glycosyl transferase, family 2
CPTC_RS07435	COG0300	oxidoreductase activity
CPTC_RS07450	COG0805	protein transport
CPTC_RS07460	COG2378	regulation of single-species biofilm formation
CPTC_RS07480	COG4122	O-methyltransferase activity
CPTC_RS07495	COG1362	aminopeptidase activity
CPTC_RS07515	COG1027	Aspartate ammonia-lyase
CPTC_RS07520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CPTC_RS07540	COG0646	methionine synthase
CPTC_RS07540	COG1410	methionine synthase
CPTC_RS07560	COG0667	Aldo Keto reductase
CPTC_RS07570	COG0167	dihydroorotate dehydrogenase activity
CPTC_RS07595	COG1461	Dihydroxyacetone kinase
CPTC_RS07600	COG2376	Dihydroxyacetone kinase
CPTC_RS07610	COG0488	(ABC) transporter
CPTC_RS07675	COG3883	PFAM NLP P60 protein
CPTC_RS07675	COG0791	NLP P60 protein
CPTC_RS07705	COG2848	UPF0210 protein
CPTC_RS07730	COG2151	metal-sulfur cluster biosynthetic enzyme
CPTC_RS07735	COG0822	iron-sulfur transferase activity
CPTC_RS07745	COG0396	ATPase activity
CPTC_RS07790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPTC_RS07795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPTC_RS07815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPTC_RS07835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPTC_RS07845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CPTC_RS07855	COG0322	excinuclease ABC activity
CPTC_RS07885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPTC_RS07900	COG0242	peptide deformylase activity
CPTC_RS07940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPTC_RS07950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPTC_RS07965	COG1090	epimerase
CPTC_RS07990	COG0006	proline dipeptidase activity
CPTC_RS07995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPTC_RS08000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CPTC_RS08005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CPTC_RS08010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CPTC_RS08030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPTC_RS08085	COG1760	l-serine dehydratase
CPTC_RS08110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPTC_RS08115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CPTC_RS08130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPTC_RS08145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPTC_RS08150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPTC_RS08180	COG1946	Acyl-CoA thioesterase
CPTC_RS08195	COG0156	8-amino-7-oxononanoate synthase activity
CPTC_RS08210	COG1560	Kdo2-lipid A biosynthetic process
CPTC_RS08215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPTC_RS08230	COG2837	iron assimilation
CPTC_RS08280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPTC_RS08285	COG3253	May function as heme-dependent peroxidase
CPTC_RS08410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPTC_RS08415	COG0450	alkyl hydroperoxide reductase
CPTC_RS08430	COG1643	Atp-dependent helicase
CPTC_RS08450	COG1349	DNA-binding transcription factor activity
CPTC_RS08455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPTC_RS08460	COG1349	DNA-binding transcription factor activity
CPTC_RS08465	COG1105	Belongs to the carbohydrate kinase PfkB family
CPTC_RS08470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CPTC_RS08470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPTC_RS08470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPTC_RS08475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPTC_RS08480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPTC_RS08490	COG2233	PERMEase
CPTC_RS08495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPTC_RS08510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CPTC_RS08525	COG1196	nuclear chromosome segregation
CPTC_RS08545	COG2137	regulation of response to DNA damage stimulus
CPTC_RS08550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CPTC_RS08560	COG1268	BioY protein
CPTC_RS08565	COG1122	ATPase activity
CPTC_RS08575	COG1842	Phage shock protein A
CPTC_RS08580	COG1396	sequence-specific DNA binding
CPTC_RS08605	COG1674	ftsk spoiiie
CPTC_RS08615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPTC_RS08655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPTC_RS08665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CPTC_RS08670	COG0534	Mate efflux family protein
CPTC_RS08715	COG3022	response to hydroperoxide
CPTC_RS08720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPTC_RS08720	COG1648	precorrin-2 dehydrogenase activity
CPTC_RS08725	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CPTC_RS08730	COG0523	cobalamin synthesis protein
CPTC_RS08735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPTC_RS08735	COG2169	Transcriptional regulator
CPTC_RS08800	COG0750	zinc metalloprotease
CPTC_RS08855	COG4974	Belongs to the 'phage' integrase family
CPTC_RS08880	COG0681	Belongs to the peptidase S26 family
CPTC_RS08895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPTC_RS08895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPTC_RS08895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPTC_RS08905	COG0336	Belongs to the RNA methyltransferase TrmD family
CPTC_RS08910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CPTC_RS08930	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CPTC_RS08960	COG1115	amino acid carrier protein
CPTC_RS08965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPTC_RS08990	COG0686	Belongs to the AlaDH PNT family
CPTC_RS08995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPTC_RS09000	COG1929	Belongs to the glycerate kinase type-1 family
CPTC_RS09020	COG0058	SHG alpha-glucan phosphorylase activity
CPTC_RS09030	COG0469	pyruvate kinase activity
CPTC_RS09040	COG0134	indole-3-glycerol-phosphate synthase activity
CPTC_RS09060	COG0483	inositol monophosphate 1-phosphatase activity
CPTC_RS09125	COG2176	DNA-directed DNA polymerase activity
CPTC_RS09150	COG1739	Uncharacterized protein family UPF0029
CPTC_RS09155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPTC_RS09180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CPTC_RS09195	COG0252	asparaginase activity
CPTC_RS09215	COG3599	regulation of cell shape
CPTC_RS09225	COG1799	cell septum assembly
CPTC_RS09230	COG1496	oxidoreductase activity
CPTC_RS09235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CPTC_RS09245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPTC_RS09275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPTC_RS09280	COG0768	penicillin binding
CPTC_RS09320	COG0142	geranyltranstransferase activity
CPTC_RS09335	COG2815	serine threonine protein kinase
CPTC_RS09335	COG0515	serine threonine protein kinase
CPTC_RS09340	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CPTC_RS09360	COG1940	carbohydrate kinase activity
CPTC_RS09365	COG0438	transferase activity, transferring glycosyl groups
CPTC_RS09375	COG0791	NLP P60 protein
CPTC_RS09425	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CPTC_RS09430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CPTC_RS09440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPTC_RS09455	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPTC_RS09460	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPTC_RS09465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPTC_RS09465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPTC_RS09470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CPTC_RS09475	COG0509	glycine decarboxylation via glycine cleavage system
CPTC_RS09505	COG0174	glutamine synthetase
CPTC_RS09655	COG2056	Na+-H+ antiporter family
CPTC_RS09670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CPTC_RS09695	COG0174	glutamine synthetase
CPTC_RS09720	COG0557	exoribonuclease II activity
CPTC_RS09735	COG3323	Protein of unknown function (DUF1653)
CPTC_RS09735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CPTC_RS09775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CPTC_RS09780	COG0596	Alpha beta hydrolase
CPTC_RS09805	COG2860	membrane
CPTC_RS09875	COG0423	glycine-tRNA ligase activity
CPTC_RS09900	COG1381	Involved in DNA repair and RecF pathway recombination
CPTC_RS09955	COG1022	Amp-dependent synthetase and ligase
CPTC_RS10010	COG1114	Component of the transport system for branched-chain amino acids
CPTC_RS10015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPTC_RS10025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPTC_RS10040	COG0747	negative chemotaxis
CPTC_RS10045	COG0601	transmembrane transport
CPTC_RS10050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPTC_RS10055	COG4172	Belongs to the ABC transporter superfamily
CPTC_RS10065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPTC_RS10070	COG2391	methyltransferase activity
CPTC_RS10075	COG4171	peptide transport system, permease
CPTC_RS10095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPTC_RS10100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPTC_RS10125	COG1280	lysine exporter protein (LysE YggA)
CPTC_RS10150	COG1307	EDD domain protein, DegV family
CPTC_RS10155	COG0406	alpha-ribazole phosphatase activity
CPTC_RS10165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPTC_RS10180	COG2832	Protein of unknown function (DUF454)
CPTC_RS10185	COG2985	domain, Protein
CPTC_RS10185	COG0569	domain protein
CPTC_RS10210	COG1530	ribonuclease E activity
CPTC_RS10225	COG2423	ornithine cyclodeaminase activity
CPTC_RS10235	COG0285	dihydrofolate synthase activity
CPTC_RS10275	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPTC_RS10310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CPTC_RS10330	COG0668	transmembrane transport
CPTC_RS10405	COG1131	(ABC) transporter
CPTC_RS10410	COG3336	cytochrome c oxidase
CPTC_RS10415	COG1966	Carbon starvation protein
CPTC_RS10435	COG0604	alcohol dehydrogenase
CPTC_RS10460	COG1376	ErfK ybiS ycfS ynhG family protein
CPTC_RS10470	COG2130	NADP-dependent
CPTC_RS10475	COG1335	isochorismatase