locus-tag	class	description
CpN1_RS00010	COG0592	DNA-directed DNA polymerase activity
CpN1_RS00025	COG0187	DNA topoisomerase II activity
CpN1_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CpN1_RS00135	COG1120	ATPase activity
CpN1_RS00140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS00145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS00150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpN1_RS00160	COG2815	serine threonine protein kinase
CpN1_RS00160	COG0515	serine threonine protein kinase
CpN1_RS00165	COG0515	serine threonine protein kinase
CpN1_RS00170	COG0768	penicillin binding
CpN1_RS00190	COG1716	ATPase activity
CpN1_RS00190	COG1716	ATPase activity
CpN1_RS00220	COG1120	ATPase activity
CpN1_RS00225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS00230	COG2239	Acts as a magnesium transporter
CpN1_RS00235	COG0366	Alpha amylase catalytic
CpN1_RS00290	COG0517	IMP dehydrogenase activity
CpN1_RS00290	COG1125	glycine betaine transport
CpN1_RS00295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpN1_RS00315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CpN1_RS00325	COG3409	Peptidoglycan-binding domain 1 protein
CpN1_RS00325	COG3757	hydrolase, family 25
CpN1_RS00350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CpN1_RS00375	COG1846	Transcriptional regulator
CpN1_RS00390	COG3180	Ammonia monooxygenase
CpN1_RS00400	COG0730	response to heat
CpN1_RS00415	COG1643	Atp-dependent helicase
CpN1_RS00425	COG0519	Catalyzes the synthesis of GMP from XMP
CpN1_RS00435	COG0393	Putative heavy-metal-binding
CpN1_RS00440	COG2501	S4 domain
CpN1_RS00465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CpN1_RS00470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CpN1_RS00480	COG3590	peptidase
CpN1_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
CpN1_RS00515	COG0277	FAD linked oxidase domain protein
CpN1_RS00545	COG1216	Glycosyl transferase, family 2
CpN1_RS00560	COG1121	(ABC) transporter
CpN1_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpN1_RS00575	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpN1_RS00600	COG0604	alcohol dehydrogenase
CpN1_RS00625	COG0471	metal ion transport
CpN1_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpN1_RS00640	COG1263	PTS System
CpN1_RS00645	COG2190	(PTS) system
CpN1_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpN1_RS00645	COG1263	PTS System
CpN1_RS00670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpN1_RS00685	COG0287	Prephenate dehydrogenase
CpN1_RS00705	COG2409	Drug exporters of the RND superfamily
CpN1_RS00710	COG0343	queuine tRNA-ribosyltransferase activity
CpN1_RS00720	COG2610	gluconate transmembrane transporter activity
CpN1_RS00725	COG3265	gluconokinase activity
CpN1_RS00730	COG1063	alcohol dehydrogenase
CpN1_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
CpN1_RS00745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpN1_RS00770	COG2610	gluconate transmembrane transporter activity
CpN1_RS00775	COG2084	Dehydrogenase
CpN1_RS00790	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpN1_RS00795	COG3442	glutamine amidotransferase
CpN1_RS00800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CpN1_RS00810	COG0778	Nitroreductase
CpN1_RS00815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CpN1_RS00820	COG2390	Transcriptional regulator
CpN1_RS00825	COG0813	purine-nucleoside phosphorylase activity
CpN1_RS00840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpN1_RS00865	COG0697	spore germination
CpN1_RS00870	COG0527	aspartate kinase activity
CpN1_RS00930	COG1840	ABC-type Fe3 transport system, periplasmic component
CpN1_RS00945	COG3852	Histidine kinase
CpN1_RS00965	COG0651	ATP synthesis coupled electron transport
CpN1_RS00975	COG2111	Na H antiporter
CpN1_RS00975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpN1_RS00995	COG4152	abc transporter atp-binding protein
CpN1_RS01030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpN1_RS01050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CpN1_RS01070	COG0494	nUDIX hydrolase
CpN1_RS01140	COG1205	dead DEAH box helicase
CpN1_RS01140	COG1111	helicase
CpN1_RS01150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CpN1_RS01150	COG1754	DNA topoisomerase type I activity
CpN1_RS01155	COG1297	OPT oligopeptide transporter protein
CpN1_RS01165	COG0470	DNA polymerase III
CpN1_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
CpN1_RS01190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CpN1_RS01200	COG1088	dTDP-glucose 4,6-dehydratase activity
CpN1_RS01210	COG1505	serine-type exopeptidase activity
CpN1_RS01220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CpN1_RS01225	COG1396	sequence-specific DNA binding
CpN1_RS01225	COG3800	Transcriptional regulator
CpN1_RS01235	COG1053	succinate dehydrogenase
CpN1_RS01240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CpN1_RS01250	COG2733	membrane
CpN1_RS01260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CpN1_RS01280	COG1882	Formate acetyltransferase
CpN1_RS01300	COG0318	PFAM AMP-dependent synthetase and ligase
CpN1_RS01315	COG5002	protein histidine kinase activity
CpN1_RS01320	COG0745	RESPONSE REGULATOR receiver
CpN1_RS01340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CpN1_RS01350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CpN1_RS01350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CpN1_RS01380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpN1_RS01380	COG1648	precorrin-2 dehydrogenase activity
CpN1_RS01395	COG2217	Heavy metal translocating P-type atpase
CpN1_RS01405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CpN1_RS01420	COG0406	alpha-ribazole phosphatase activity
CpN1_RS01430	COG0785	Cytochrome C biogenesis protein
CpN1_RS01440	COG0275	rRNA processing
CpN1_RS01455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS01460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpN1_RS01490	COG3069	C4-dicarboxylate transmembrane transporter activity
CpN1_RS01495	COG4948	Mandelate Racemase Muconate Lactonizing
CpN1_RS01520	COG0039	L-malate dehydrogenase activity
CpN1_RS01525	COG0644	oxidoreductase
CpN1_RS01530	COG0142	geranyltranstransferase activity
CpN1_RS01555	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpN1_RS01585	COG1902	pentaerythritol trinitrate reductase activity
CpN1_RS01605	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpN1_RS01615	COG1121	(ABC) transporter
CpN1_RS01620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpN1_RS01650	COG2197	response regulator
CpN1_RS01660	COG1131	(ABC) transporter
CpN1_RS01675	COG0701	Predicted permease
CpN1_RS01745	COG1302	Protein conserved in bacteria
CpN1_RS01840	COG0814	amino acid
CpN1_RS01845	COG1760	l-serine dehydratase
CpN1_RS01850	COG0252	asparaginase activity
CpN1_RS01855	COG0671	phosphoesterase, PA-phosphatase related
CpN1_RS01900	COG1175	transmembrane transport
CpN1_RS01905	COG3833	ABC-type maltose transport systems, permease component
CpN1_RS01925	COG3842	ATPase activity
CpN1_RS01930	COG0201	protein transport
CpN1_RS01985	COG0203	ribosomal protein L17
CpN1_RS02005	COG1404	Belongs to the peptidase S8 family
CpN1_RS02015	COG1674	ftsk spoiiie
CpN1_RS02070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CpN1_RS02135	COG0516	GMP reductase activity
CpN1_RS02180	COG2011	ABC-type metal ion transport system permease component
CpN1_RS02190	COG1464	Belongs to the NlpA lipoprotein family
CpN1_RS02195	COG1464	Belongs to the NlpA lipoprotein family
CpN1_RS02215	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpN1_RS02220	COG1121	(ABC) transporter
CpN1_RS02230	COG1321	iron dependent repressor
CpN1_RS02230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpN1_RS02235	COG1321	iron dependent repressor
CpN1_RS02240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CpN1_RS02245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CpN1_RS02280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS02285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CpN1_RS02300	COG2838	Isocitrate dehydrogenase
CpN1_RS02305	COG2814	Major facilitator Superfamily
CpN1_RS02310	COG0789	Transcriptional regulator
CpN1_RS02310	COG4978	Transcriptional regulator
CpN1_RS02325	COG0180	Tryptophanyl-tRNA synthetase
CpN1_RS02330	COG1295	ribonuclease BN
CpN1_RS02335	COG1686	Belongs to the peptidase S11 family
CpN1_RS02370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpN1_RS02375	COG1473	amidohydrolase
CpN1_RS02375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CpN1_RS02390	COG2814	Major facilitator Superfamily
CpN1_RS02400	COG4770	biotin carboxylase activity
CpN1_RS02405	COG2897	thiosulfate sulfurtransferase activity
CpN1_RS02410	COG0189	ligase activity
CpN1_RS02415	COG2755	lipolytic protein G-D-S-L family
CpN1_RS02415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpN1_RS02425	COG0424	maF-like protein
CpN1_RS02430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CpN1_RS02435	COG1609	Transcriptional regulator
CpN1_RS02445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpN1_RS02450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpN1_RS02455	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CpN1_RS02455	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CpN1_RS02505	COG1316	TRANSCRIPTIONal
CpN1_RS02515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CpN1_RS02545	COG1482	cell wall glycoprotein biosynthetic process
CpN1_RS02570	COG0745	RESPONSE REGULATOR receiver
CpN1_RS02575	COG5002	protein histidine kinase activity
CpN1_RS02590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CpN1_RS02630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CpN1_RS02635	COG2135	peptidase activity
CpN1_RS02640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CpN1_RS02675	COG0513	Belongs to the DEAD box helicase family
CpN1_RS02700	COG0210	DNA helicase
CpN1_RS02710	COG2816	NAD+ diphosphatase activity
CpN1_RS02735	COG3480	Lon protease (S16) C-terminal proteolytic domain
CpN1_RS02850	COG0483	inositol monophosphate 1-phosphatase activity
CpN1_RS02855	COG0483	inositol monophosphate 1-phosphatase activity
CpN1_RS02870	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CpN1_RS02875	COG2884	Cell division ATP-binding protein ftsE
CpN1_RS02880	COG2177	Part of the ABC transporter FtsEX involved in
CpN1_RS02890	COG0288	reversible hydration of carbon dioxide
CpN1_RS02935	COG0564	pseudouridine synthase activity
CpN1_RS02960	COG0706	membrane insertase activity
CpN1_RS02965	COG3764	Sortase (surface protein transpeptidase)
CpN1_RS02980	COG2197	response regulator
CpN1_RS03000	COG5650	phosphatidylinositol metabolic process
CpN1_RS03015	COG2271	Major facilitator Superfamily
CpN1_RS03025	COG2814	Major facilitator Superfamily
CpN1_RS03030	COG0431	NADPH-dependent FMN reductase
CpN1_RS03060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CpN1_RS03090	COG1316	TRANSCRIPTIONal
CpN1_RS03100	COG0154	amidase activity
CpN1_RS03105	COG0077	Prephenate dehydratase
CpN1_RS03125	COG2188	Transcriptional regulator
CpN1_RS03140	COG0561	phosphatase activity
CpN1_RS03150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpN1_RS03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS03170	COG2271	Major facilitator Superfamily
CpN1_RS03175	COG0584	glycerophosphoryl diester phosphodiesterase
CpN1_RS03185	COG0671	phosphoesterase, PA-phosphatase related
CpN1_RS03195	COG1216	Glycosyl transferase, family 2
CpN1_RS03200	COG0671	phosphoesterase, PA-phosphatase related
CpN1_RS03205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CpN1_RS03210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CpN1_RS03225	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpN1_RS03225	COG5479	isomerase activity
CpN1_RS03235	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpN1_RS03240	COG0318	PFAM AMP-dependent synthetase and ligase
CpN1_RS03245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CpN1_RS03245	COG3321	synthase
CpN1_RS03245	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CpN1_RS03250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpN1_RS03295	COG0500	methyltransferase
CpN1_RS03300	COG0438	transferase activity, transferring glycosyl groups
CpN1_RS03320	COG2755	lipolytic protein G-D-S-L family
CpN1_RS03320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpN1_RS03325	COG4981	capsule polysaccharide biosynthetic process
CpN1_RS03335	COG1472	Belongs to the glycosyl hydrolase 3 family
CpN1_RS03345	COG1012	belongs to the aldehyde dehydrogenase family
CpN1_RS03360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CpN1_RS03375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpN1_RS03375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpN1_RS03395	COG0831	urea catabolic process
CpN1_RS03400	COG0832	Belongs to the urease beta subunit family
CpN1_RS03405	COG0804	urea catabolic process
CpN1_RS03410	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CpN1_RS03415	COG0830	nickel cation binding
CpN1_RS03420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CpN1_RS03425	COG0829	nickel cation binding
CpN1_RS03435	COG4139	cobalamin transport
CpN1_RS03440	COG1120	ATPase activity
CpN1_RS03455	COG2181	nitrate reductase activity
CpN1_RS03455	COG0247	lactate metabolic process
CpN1_RS03480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpN1_RS03510	COG0443	Heat shock 70 kDa protein
CpN1_RS03525	COG0789	Transcriptional regulator
CpN1_RS03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CpN1_RS03570	COG1136	(ABC) transporter
CpN1_RS03575	COG0577	efflux transmembrane transporter activity
CpN1_RS03575	COG1136	(ABC) transporter
CpN1_RS03595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CpN1_RS03625	COG1131	(ABC) transporter
CpN1_RS03665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CpN1_RS03680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CpN1_RS03695	COG0191	fructose-bisphosphate aldolase activity
CpN1_RS03730	COG4129	membrane
CpN1_RS03740	COG4129	membrane
CpN1_RS03755	COG3005	denitrification pathway
CpN1_RS03760	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CpN1_RS03770	COG1333	cytochrome c biogenesis protein
CpN1_RS03775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpN1_RS03805	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CpN1_RS03810	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CpN1_RS03830	COG0280	phosphate acetyltransferase
CpN1_RS03845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpN1_RS03870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CpN1_RS03880	COG0456	acetyltransferase
CpN1_RS03885	COG0242	peptide deformylase activity
CpN1_RS03905	COG1051	belongs to the nudix hydrolase family
CpN1_RS03925	COG0651	ATP synthesis coupled electron transport
CpN1_RS03930	COG1006	Multisubunit Na H antiporter MnhC subunit
CpN1_RS03935	COG2111	Na H antiporter
CpN1_RS03935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpN1_RS03975	COG2326	polyphosphate kinase activity
CpN1_RS03980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CpN1_RS03995	COG1301	dicarboxylic acid transport
CpN1_RS04000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CpN1_RS04000	COG0425	Belongs to the sulfur carrier protein TusA family
CpN1_RS04005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CpN1_RS04010	COG2027	D-alanyl-D-alanine carboxypeptidase
CpN1_RS04020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CpN1_RS04025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CpN1_RS04030	COG0302	gtp cyclohydrolase
CpN1_RS04035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpN1_RS04065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CpN1_RS04070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CpN1_RS04075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpN1_RS04080	COG1012	belongs to the aldehyde dehydrogenase family
CpN1_RS04085	COG1301	dicarboxylic acid transport
CpN1_RS04100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpN1_RS04115	COG1957	nucleoside hydrolase
CpN1_RS04120	COG0477	Major facilitator Superfamily
CpN1_RS04145	COG0288	reversible hydration of carbon dioxide
CpN1_RS04155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CpN1_RS04170	COG2847	Copper chaperone PCu(A)C
CpN1_RS04175	COG1329	Transcriptional regulator
CpN1_RS04195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpN1_RS04205	COG1609	Transcriptional regulator
CpN1_RS04245	COG0028	Belongs to the TPP enzyme family
CpN1_RS04275	COG0745	RESPONSE REGULATOR receiver
CpN1_RS04280	COG2205	protein histidine kinase activity
CpN1_RS04290	COG0537	adenosine 5'-monophosphoramidase activity
CpN1_RS04295	COG0151	Belongs to the GarS family
CpN1_RS04300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CpN1_RS04305	COG0569	domain protein
CpN1_RS04310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CpN1_RS04330	COG0386	Belongs to the glutathione peroxidase family
CpN1_RS04335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpN1_RS04340	COG0047	phosphoribosylformylglycinamidine synthase activity
CpN1_RS04345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpN1_RS04355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpN1_RS04360	COG1780	Probably involved in ribonucleotide reductase function
CpN1_RS04385	COG0354	folic acid binding
CpN1_RS04400	COG1597	lipid kinase activity
CpN1_RS04430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CpN1_RS04455	COG1132	(ABC) transporter
CpN1_RS04460	COG4988	ABC transporter
CpN1_RS04465	COG1294	oxidase, subunit
CpN1_RS04470	COG1271	oxidase subunit
CpN1_RS04490	COG0371	Dehydrogenase
CpN1_RS04510	COG1045	serine acetyltransferase
CpN1_RS04525	COG2197	response regulator
CpN1_RS04565	COG0647	UMP catabolic process
CpN1_RS04580	COG0497	DNA recombination
CpN1_RS04595	COG0494	nUDIX hydrolase
CpN1_RS04600	COG4974	Belongs to the 'phage' integrase family
CpN1_RS04620	COG3104	oligopeptide transport
CpN1_RS04625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CpN1_RS04635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CpN1_RS04650	COG1160	GTP binding
CpN1_RS04655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpN1_RS04665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpN1_RS04670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpN1_RS04675	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CpN1_RS04680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS04685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS04690	COG1120	ATPase activity
CpN1_RS04695	COG4264	IucA IucC family
CpN1_RS04725	COG0653	protein targeting
CpN1_RS04765	COG1253	flavin adenine dinucleotide binding
CpN1_RS04770	COG0513	Belongs to the DEAD box helicase family
CpN1_RS04775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CpN1_RS04785	COG0598	Magnesium transport protein CorA
CpN1_RS04805	COG0477	Major facilitator Superfamily
CpN1_RS04830	COG0463	Glycosyl transferase, family 2
CpN1_RS04880	COG0300	oxidoreductase activity
CpN1_RS04895	COG0805	protein transport
CpN1_RS04905	COG2378	regulation of single-species biofilm formation
CpN1_RS04925	COG4122	O-methyltransferase activity
CpN1_RS04940	COG1362	aminopeptidase activity
CpN1_RS04960	COG1027	Aspartate ammonia-lyase
CpN1_RS04965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpN1_RS04985	COG0646	methionine synthase
CpN1_RS04985	COG1410	methionine synthase
CpN1_RS05005	COG0667	Aldo Keto reductase
CpN1_RS05015	COG0167	dihydroorotate dehydrogenase activity
CpN1_RS05040	COG1461	Dihydroxyacetone kinase
CpN1_RS05045	COG2376	Dihydroxyacetone kinase
CpN1_RS05055	COG0488	(ABC) transporter
CpN1_RS05120	COG3883	PFAM NLP P60 protein
CpN1_RS05120	COG0791	NLP P60 protein
CpN1_RS05150	COG2848	UPF0210 protein
CpN1_RS05170	COG0488	(ABC) transporter
CpN1_RS05175	COG2151	metal-sulfur cluster biosynthetic enzyme
CpN1_RS05180	COG0822	iron-sulfur transferase activity
CpN1_RS05190	COG0396	ATPase activity
CpN1_RS05235	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CpN1_RS05240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CpN1_RS05260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpN1_RS05280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CpN1_RS05290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CpN1_RS05300	COG0322	excinuclease ABC activity
CpN1_RS05330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CpN1_RS05345	COG0242	peptide deformylase activity
CpN1_RS05385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CpN1_RS05395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CpN1_RS05410	COG1090	epimerase
CpN1_RS05435	COG0006	proline dipeptidase activity
CpN1_RS05440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CpN1_RS05445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CpN1_RS05450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CpN1_RS05455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CpN1_RS05475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CpN1_RS05530	COG1760	l-serine dehydratase
CpN1_RS05555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpN1_RS05560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CpN1_RS05575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CpN1_RS05590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpN1_RS05595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpN1_RS05625	COG1946	Acyl-CoA thioesterase
CpN1_RS05640	COG0156	8-amino-7-oxononanoate synthase activity
CpN1_RS05655	COG1560	Kdo2-lipid A biosynthetic process
CpN1_RS05660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CpN1_RS05675	COG2837	iron assimilation
CpN1_RS05725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CpN1_RS05730	COG3253	May function as heme-dependent peroxidase
CpN1_RS05815	COG2890	protein-(glutamine-N5) methyltransferase activity
CpN1_RS05855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CpN1_RS05860	COG0450	alkyl hydroperoxide reductase
CpN1_RS05875	COG1643	Atp-dependent helicase
CpN1_RS05895	COG1349	DNA-binding transcription factor activity
CpN1_RS05900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CpN1_RS05905	COG1349	DNA-binding transcription factor activity
CpN1_RS05910	COG1105	Belongs to the carbohydrate kinase PfkB family
CpN1_RS05915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpN1_RS05915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpN1_RS05915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CpN1_RS05920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpN1_RS05925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpN1_RS05935	COG2233	PERMEase
CpN1_RS05940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CpN1_RS05955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CpN1_RS05970	COG1196	nuclear chromosome segregation
CpN1_RS05990	COG2137	regulation of response to DNA damage stimulus
CpN1_RS05995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CpN1_RS06005	COG1268	BioY protein
CpN1_RS06010	COG1122	ATPase activity
CpN1_RS06020	COG1842	Phage shock protein A
CpN1_RS06025	COG1396	sequence-specific DNA binding
CpN1_RS06050	COG1674	ftsk spoiiie
CpN1_RS06060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CpN1_RS06100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CpN1_RS06110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CpN1_RS06115	COG0534	Mate efflux family protein
CpN1_RS06160	COG3022	response to hydroperoxide
CpN1_RS06165	COG1648	precorrin-2 dehydrogenase activity
CpN1_RS06165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpN1_RS06170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CpN1_RS06175	COG0523	cobalamin synthesis protein
CpN1_RS06180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CpN1_RS06180	COG2169	Transcriptional regulator
CpN1_RS06245	COG0750	zinc metalloprotease
CpN1_RS06300	COG4974	Belongs to the 'phage' integrase family
CpN1_RS06325	COG0681	Belongs to the peptidase S26 family
CpN1_RS06340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpN1_RS06340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpN1_RS06340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpN1_RS06350	COG0336	Belongs to the RNA methyltransferase TrmD family
CpN1_RS06355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CpN1_RS06375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CpN1_RS06405	COG1115	amino acid carrier protein
CpN1_RS06410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpN1_RS06435	COG0686	Belongs to the AlaDH PNT family
CpN1_RS06440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CpN1_RS06445	COG1929	Belongs to the glycerate kinase type-1 family
CpN1_RS06465	COG0058	SHG alpha-glucan phosphorylase activity
CpN1_RS06475	COG0469	pyruvate kinase activity
CpN1_RS06485	COG0134	indole-3-glycerol-phosphate synthase activity
CpN1_RS06505	COG0483	inositol monophosphate 1-phosphatase activity
CpN1_RS06570	COG2176	DNA-directed DNA polymerase activity
CpN1_RS06595	COG1739	Uncharacterized protein family UPF0029
CpN1_RS06600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CpN1_RS06625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CpN1_RS06640	COG0252	asparaginase activity
CpN1_RS06660	COG3599	regulation of cell shape
CpN1_RS06670	COG1799	cell septum assembly
CpN1_RS06675	COG1496	oxidoreductase activity
CpN1_RS06680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CpN1_RS06690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CpN1_RS06720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CpN1_RS06725	COG0768	penicillin binding
CpN1_RS06765	COG0142	geranyltranstransferase activity
CpN1_RS06780	COG2815	serine threonine protein kinase
CpN1_RS06780	COG0515	serine threonine protein kinase
CpN1_RS06785	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CpN1_RS06805	COG1940	carbohydrate kinase activity
CpN1_RS06810	COG0438	transferase activity, transferring glycosyl groups
CpN1_RS06820	COG0791	NLP P60 protein
CpN1_RS06870	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CpN1_RS06875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CpN1_RS06885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CpN1_RS06900	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpN1_RS06905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpN1_RS06905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpN1_RS06910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CpN1_RS06915	COG0509	glycine decarboxylation via glycine cleavage system
CpN1_RS06945	COG0174	glutamine synthetase
CpN1_RS07030	COG1074	ATP-dependent DNA helicase activity
CpN1_RS07095	COG2056	Na+-H+ antiporter family
CpN1_RS07105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CpN1_RS07130	COG0174	glutamine synthetase
CpN1_RS07155	COG0557	exoribonuclease II activity
CpN1_RS07170	COG3323	Protein of unknown function (DUF1653)
CpN1_RS07170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CpN1_RS07210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CpN1_RS07215	COG0596	Alpha beta hydrolase
CpN1_RS07240	COG2860	membrane
CpN1_RS07310	COG0423	glycine-tRNA ligase activity
CpN1_RS07335	COG1381	Involved in DNA repair and RecF pathway recombination
CpN1_RS07390	COG1022	Amp-dependent synthetase and ligase
CpN1_RS07440	COG1114	Component of the transport system for branched-chain amino acids
CpN1_RS07445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpN1_RS07455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpN1_RS07470	COG0747	negative chemotaxis
CpN1_RS07475	COG0601	transmembrane transport
CpN1_RS07480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpN1_RS07485	COG4172	Belongs to the ABC transporter superfamily
CpN1_RS07495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CpN1_RS07500	COG2391	methyltransferase activity
CpN1_RS07505	COG4171	peptide transport system, permease
CpN1_RS07525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpN1_RS07530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpN1_RS07555	COG1280	lysine exporter protein (LysE YggA)
CpN1_RS07580	COG1307	EDD domain protein, DegV family
CpN1_RS07585	COG0406	alpha-ribazole phosphatase activity
CpN1_RS07595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CpN1_RS07610	COG2832	Protein of unknown function (DUF454)
CpN1_RS07615	COG2985	domain, Protein
CpN1_RS07615	COG0569	domain protein
CpN1_RS07640	COG1530	ribonuclease E activity
CpN1_RS07655	COG2423	ornithine cyclodeaminase activity
CpN1_RS07665	COG0285	dihydrofolate synthase activity
CpN1_RS07705	COG0544	peptidyl-prolyl cis-trans isomerase activity
CpN1_RS07740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CpN1_RS07755	COG0668	transmembrane transport
CpN1_RS07830	COG1131	(ABC) transporter
CpN1_RS07835	COG3336	cytochrome c oxidase
CpN1_RS07840	COG1966	Carbon starvation protein
CpN1_RS07855	COG0604	alcohol dehydrogenase
CpN1_RS07880	COG1376	ErfK ybiS ycfS ynhG family protein
CpN1_RS07890	COG2130	NADP-dependent
CpN1_RS07895	COG1335	isochorismatase
CpN1_RS07940	COG2197	response regulator
CpN1_RS07985	COG1234	tRNA 3'-trailer cleavage
CpN1_RS08010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CpN1_RS08060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpN1_RS08070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpN1_RS08090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CpN1_RS08155	COG0033	Phosphoglucomutase
CpN1_RS08170	COG1136	(ABC) transporter
CpN1_RS08170	COG0577	efflux transmembrane transporter activity
CpN1_RS08175	COG0577	efflux transmembrane transporter activity
CpN1_RS08175	COG1136	(ABC) transporter
CpN1_RS08205	COG2835	tetraacyldisaccharide 4'-kinase activity
CpN1_RS08210	COG0165	Argininosuccinate lyase
CpN1_RS08230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CpN1_RS08245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CpN1_RS08260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpN1_RS08275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CpN1_RS08290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpN1_RS08300	COG3973	AAA domain
CpN1_RS08320	COG0237	dephospho-CoA kinase activity
CpN1_RS08330	COG0539	negative regulation of cytoplasmic translation
CpN1_RS08335	COG2226	methyltransferase
CpN1_RS08360	COG0765	amino acid transport
CpN1_RS08385	COG0742	ribosomal rna small subunit methyltransferase
CpN1_RS08390	COG0511	ligase activity, forming carbon-carbon bonds
CpN1_RS08400	COG1461	Dihydroxyacetone kinase
CpN1_RS08405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CpN1_RS08410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CpN1_RS08465	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpN1_RS08495	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpN1_RS08515	COG0473	3-isopropylmalate dehydrogenase activity
CpN1_RS08555	COG0668	transmembrane transport
CpN1_RS08580	COG0583	DNA-binding transcription factor activity
CpN1_RS08590	COG0667	Aldo Keto reductase
CpN1_RS08600	COG0205	6-phosphofructokinase activity
CpN1_RS08610	COG1120	ATPase activity
CpN1_RS08615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpN1_RS08680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CpN1_RS08700	COG1119	ATPase activity
CpN1_RS08725	COG0346	lactoylglutathione lyase activity
CpN1_RS08765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CpN1_RS08770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CpN1_RS08775	COG0356	it plays a direct role in the translocation of protons across the membrane
CpN1_RS08825	COG0460	homoserine dehydrogenase
CpN1_RS08830	COG0019	diaminopimelate decarboxylase activity
CpN1_RS08840	COG1620	l-lactate permease
CpN1_RS08845	COG0247	lactate metabolic process
CpN1_RS08850	COG1139	Iron-sulfur cluster binding protein
CpN1_RS08855	COG1556	Lactate utilization protein
CpN1_RS08910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CpN1_RS08915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpN1_RS08945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CpN1_RS08965	COG2017	converts alpha-aldose to the beta-anomer
CpN1_RS08980	COG2272	Belongs to the type-B carboxylesterase lipase family
CpN1_RS08985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CpN1_RS08995	COG1132	(ABC) transporter
CpN1_RS09000	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpN1_RS09000	COG0567	Dehydrogenase, E1 component
CpN1_RS09010	COG2239	Acts as a magnesium transporter
CpN1_RS09040	COG4122	O-methyltransferase activity
CpN1_RS09050	COG0297	glycogen (starch) synthase activity
CpN1_RS09075	COG0463	Glycosyl transferase, family 2
CpN1_RS09080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpN1_RS09085	COG1611	Belongs to the LOG family
CpN1_RS09090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpN1_RS09100	COG1113	amino acid transport
CpN1_RS09110	COG1113	amino acid transport
CpN1_RS09145	COG4166	transmembrane transport
CpN1_RS09150	COG1217	gtp-binding protein TYPA
CpN1_RS09180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpN1_RS09185	COG0601	transmembrane transport
CpN1_RS09190	COG4166	transmembrane transport
CpN1_RS09200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CpN1_RS09210	COG1122	ATPase activity
CpN1_RS09215	COG4721	ABC-type cobalt transport system, permease component
CpN1_RS09225	COG2354	Protein conserved in bacteria
CpN1_RS09230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CpN1_RS09240	COG1132	(ABC) transporter
CpN1_RS09245	COG2824	Alkylphosphonate utilization operon protein PhnA
CpN1_RS09260	COG0012	GTP binding
CpN1_RS09295	COG1494	fructose-1,6-bisphosphatase
CpN1_RS09300	COG0114	fumarate hydratase activity
CpN1_RS09370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CpN1_RS09430	COG3956	TIGRFAM MazG family protein
CpN1_RS09435	COG0531	amino acid
CpN1_RS09445	COG1309	transcriptional regulator
CpN1_RS09460	COG2132	Multicopper oxidase
CpN1_RS09465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CpN1_RS09470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CpN1_RS09475	COG1523	belongs to the glycosyl hydrolase 13 family
CpN1_RS09500	COG0193	aminoacyl-tRNA hydrolase activity
CpN1_RS09510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CpN1_RS09515	COG0596	Alpha beta hydrolase
CpN1_RS09540	COG0561	phosphatase activity
CpN1_RS09550	COG2326	polyphosphate kinase activity
CpN1_RS09565	COG0488	(ABC) transporter
CpN1_RS09580	COG3583	domain protein
CpN1_RS09585	COG0084	hydrolase, TatD family'
CpN1_RS09600	COG3949	Membrane
CpN1_RS09605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpN1_RS09610	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CpN1_RS09620	COG2259	Doxx family
CpN1_RS09640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CpN1_RS09660	COG0521	Mo-molybdopterin cofactor biosynthetic process
CpN1_RS09660	COG0315	cyclic pyranopterin monophosphate synthase activity
CpN1_RS09665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CpN1_RS09670	COG2205	protein histidine kinase activity
CpN1_RS09675	COG0745	RESPONSE REGULATOR receiver
CpN1_RS09685	COG0254	rRNA binding
CpN1_RS09715	COG1309	transcriptional regulator
CpN1_RS09725	COG0765	amino acid transport
CpN1_RS09730	COG0765	amino acid transport
CpN1_RS09735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpN1_RS09740	COG1126	abc transporter atp-binding protein
CpN1_RS09790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpN1_RS09800	COG1201	RNA secondary structure unwinding
CpN1_RS09805	COG1218	3'(2'),5'-bisphosphate nucleotidase
CpN1_RS09820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CpN1_RS09840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpN1_RS09850	COG0601	transmembrane transport
CpN1_RS09855	COG4166	transmembrane transport
CpN1_RS09870	COG0019	diaminopimelate decarboxylase activity
CpN1_RS09875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CpN1_RS09880	COG0534	Mate efflux family protein
CpN1_RS09895	COG3757	hydrolase, family 25
CpN1_RS09905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpN1_RS09915	COG1024	Enoyl-CoA hydratase
CpN1_RS09920	COG0656	L-ascorbic acid biosynthetic process
CpN1_RS09935	COG0545	Peptidyl-prolyl cis-trans isomerase
CpN1_RS09940	COG0372	Belongs to the citrate synthase family
CpN1_RS09960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpN1_RS09965	COG2252	PERMEase
CpN1_RS09990	COG1652	LysM domain
CpN1_RS10005	COG1061	Type III restriction enzyme res subunit
CpN1_RS10045	COG1131	(ABC) transporter
CpN1_RS10060	COG1842	Phage shock protein A
CpN1_RS10065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CpN1_RS10080	COG0477	Major facilitator Superfamily
CpN1_RS10085	COG0305	Participates in initiation and elongation during chromosome replication
CpN1_RS10090	COG3387	PFAM Glycoside hydrolase 15-related
CpN1_RS10100	COG0629	single-stranded DNA binding
CpN1_RS10120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpN1_RS10140	COG0300	oxidoreductase activity
CpN1_RS10155	COG0586	Pfam SNARE associated Golgi protein
CpN1_RS10160	COG0783	Belongs to the Dps family
CpN1_RS10165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpN1_RS10170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CpN1_RS10170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CpN1_RS10180	COG1511	domain protein
CpN1_RS10190	COG0577	efflux transmembrane transporter activity
CpN1_RS10190	COG1136	(ABC) transporter
CpN1_RS10210	COG4585	Histidine kinase
CpN1_RS10215	COG2197	response regulator
CpN1_RS10230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CpN1_RS10245	COG2186	Transcriptional regulator
CpN1_RS10250	COG0747	negative chemotaxis
CpN1_RS10255	COG0601	transmembrane transport
CpN1_RS10260	COG0444	Belongs to the ABC transporter superfamily
CpN1_RS10265	COG4608	Belongs to the ABC transporter superfamily
CpN1_RS10270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CpN1_RS10310	COG3422	double-strand break repair
CpN1_RS10325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CpN1_RS10345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CpN1_RS10350	COG0512	Glutamine amidotransferase of anthranilate synthase
CpN1_RS10360	COG0134	indole-3-glycerol-phosphate synthase activity
CpN1_RS10360	COG0135	phosphoribosylanthranilate isomerase activity
CpN1_RS10395	COG1687	branched-chain amino acid
CpN1_RS10400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CpN1_RS10405	COG1678	Uncharacterized ACR, COG1678
CpN1_RS10410	COG0617	tRNA 3'-terminal CCA addition
CpN1_RS10445	COG3409	Peptidoglycan-binding domain 1 protein
CpN1_RS10445	COG0860	N-Acetylmuramoyl-L-alanine amidase
CpN1_RS10460	COG1192	Involved in chromosome partitioning
CpN1_RS10475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CpN1_RS10485	COG0230	Belongs to the bacterial ribosomal protein bL34 family