locus-tag	class	description
CpPa04_RS00010	COG0592	DNA-directed DNA polymerase activity
CpPa04_RS00025	COG0187	DNA topoisomerase II activity
CpPa04_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CpPa04_RS00135	COG1120	ATPase activity
CpPa04_RS00140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS00145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS00150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpPa04_RS00160	COG0515	serine threonine protein kinase
CpPa04_RS00160	COG2815	serine threonine protein kinase
CpPa04_RS00165	COG0515	serine threonine protein kinase
CpPa04_RS00170	COG0768	penicillin binding
CpPa04_RS00190	COG1716	ATPase activity
CpPa04_RS00190	COG1716	ATPase activity
CpPa04_RS00220	COG1120	ATPase activity
CpPa04_RS00225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS00230	COG2239	Acts as a magnesium transporter
CpPa04_RS00235	COG0366	Alpha amylase catalytic
CpPa04_RS00290	COG0517	IMP dehydrogenase activity
CpPa04_RS00290	COG1125	glycine betaine transport
CpPa04_RS00300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpPa04_RS00320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CpPa04_RS00330	COG3409	Peptidoglycan-binding domain 1 protein
CpPa04_RS00330	COG3757	hydrolase, family 25
CpPa04_RS00355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CpPa04_RS00380	COG1846	Transcriptional regulator
CpPa04_RS00395	COG3180	Ammonia monooxygenase
CpPa04_RS00405	COG0730	response to heat
CpPa04_RS00420	COG1643	Atp-dependent helicase
CpPa04_RS00430	COG0519	Catalyzes the synthesis of GMP from XMP
CpPa04_RS00440	COG0393	Putative heavy-metal-binding
CpPa04_RS00445	COG2501	S4 domain
CpPa04_RS00470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CpPa04_RS00475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CpPa04_RS00485	COG3590	peptidase
CpPa04_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
CpPa04_RS00520	COG0277	FAD linked oxidase domain protein
CpPa04_RS00550	COG1216	Glycosyl transferase, family 2
CpPa04_RS00560	COG1121	(ABC) transporter
CpPa04_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpPa04_RS00575	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpPa04_RS00600	COG0604	alcohol dehydrogenase
CpPa04_RS00625	COG0471	metal ion transport
CpPa04_RS00640	COG1263	PTS System
CpPa04_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpPa04_RS00645	COG2190	(PTS) system
CpPa04_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpPa04_RS00645	COG1263	PTS System
CpPa04_RS00670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpPa04_RS00685	COG0287	Prephenate dehydrogenase
CpPa04_RS00705	COG2409	Drug exporters of the RND superfamily
CpPa04_RS00710	COG0343	queuine tRNA-ribosyltransferase activity
CpPa04_RS00720	COG2610	gluconate transmembrane transporter activity
CpPa04_RS00725	COG3265	gluconokinase activity
CpPa04_RS00730	COG1063	alcohol dehydrogenase
CpPa04_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
CpPa04_RS00750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpPa04_RS00775	COG2610	gluconate transmembrane transporter activity
CpPa04_RS00780	COG2084	Dehydrogenase
CpPa04_RS00795	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpPa04_RS00805	COG3442	glutamine amidotransferase
CpPa04_RS00810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CpPa04_RS00820	COG0778	Nitroreductase
CpPa04_RS00825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CpPa04_RS00830	COG2390	Transcriptional regulator
CpPa04_RS00835	COG0813	purine-nucleoside phosphorylase activity
CpPa04_RS00850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpPa04_RS00875	COG0697	spore germination
CpPa04_RS00880	COG0527	aspartate kinase activity
CpPa04_RS00940	COG1840	ABC-type Fe3 transport system, periplasmic component
CpPa04_RS00975	COG0651	ATP synthesis coupled electron transport
CpPa04_RS00985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpPa04_RS00985	COG2111	Na H antiporter
CpPa04_RS01005	COG4152	abc transporter atp-binding protein
CpPa04_RS01055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CpPa04_RS01075	COG0494	nUDIX hydrolase
CpPa04_RS01145	COG1111	helicase
CpPa04_RS01145	COG1205	dead DEAH box helicase
CpPa04_RS01155	COG1754	DNA topoisomerase type I activity
CpPa04_RS01155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CpPa04_RS01160	COG1297	OPT oligopeptide transporter protein
CpPa04_RS01170	COG0470	DNA polymerase III
CpPa04_RS01185	COG0318	PFAM AMP-dependent synthetase and ligase
CpPa04_RS01195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CpPa04_RS01205	COG1088	dTDP-glucose 4,6-dehydratase activity
CpPa04_RS01215	COG1505	serine-type exopeptidase activity
CpPa04_RS01230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CpPa04_RS01235	COG3800	Transcriptional regulator
CpPa04_RS01235	COG1396	sequence-specific DNA binding
CpPa04_RS01245	COG1053	succinate dehydrogenase
CpPa04_RS01250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CpPa04_RS01260	COG2733	membrane
CpPa04_RS01270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CpPa04_RS01290	COG1882	Formate acetyltransferase
CpPa04_RS01310	COG0318	PFAM AMP-dependent synthetase and ligase
CpPa04_RS01325	COG5002	protein histidine kinase activity
CpPa04_RS01330	COG0745	RESPONSE REGULATOR receiver
CpPa04_RS01350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CpPa04_RS01370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CpPa04_RS01370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CpPa04_RS01400	COG1648	precorrin-2 dehydrogenase activity
CpPa04_RS01400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpPa04_RS01415	COG2217	Heavy metal translocating P-type atpase
CpPa04_RS01425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CpPa04_RS01440	COG0406	alpha-ribazole phosphatase activity
CpPa04_RS01450	COG0785	Cytochrome C biogenesis protein
CpPa04_RS01460	COG0275	rRNA processing
CpPa04_RS01475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS01480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpPa04_RS01515	COG4948	Mandelate Racemase Muconate Lactonizing
CpPa04_RS01540	COG0039	L-malate dehydrogenase activity
CpPa04_RS01545	COG0644	oxidoreductase
CpPa04_RS01550	COG0142	geranyltranstransferase activity
CpPa04_RS01575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpPa04_RS01605	COG1902	pentaerythritol trinitrate reductase activity
CpPa04_RS01625	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpPa04_RS01635	COG1121	(ABC) transporter
CpPa04_RS01640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpPa04_RS01670	COG2197	response regulator
CpPa04_RS01680	COG1131	(ABC) transporter
CpPa04_RS01695	COG0701	Predicted permease
CpPa04_RS01765	COG1302	Protein conserved in bacteria
CpPa04_RS01865	COG0814	amino acid
CpPa04_RS01870	COG1760	l-serine dehydratase
CpPa04_RS01875	COG0252	asparaginase activity
CpPa04_RS01880	COG0671	phosphoesterase, PA-phosphatase related
CpPa04_RS01930	COG1175	transmembrane transport
CpPa04_RS01935	COG3833	ABC-type maltose transport systems, permease component
CpPa04_RS01955	COG3842	ATPase activity
CpPa04_RS01960	COG0201	protein transport
CpPa04_RS02015	COG0203	ribosomal protein L17
CpPa04_RS02035	COG1404	Belongs to the peptidase S8 family
CpPa04_RS02105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CpPa04_RS02175	COG0516	GMP reductase activity
CpPa04_RS02220	COG2011	ABC-type metal ion transport system permease component
CpPa04_RS02230	COG1464	Belongs to the NlpA lipoprotein family
CpPa04_RS02235	COG1464	Belongs to the NlpA lipoprotein family
CpPa04_RS02255	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpPa04_RS02260	COG1121	(ABC) transporter
CpPa04_RS02270	COG1321	iron dependent repressor
CpPa04_RS02270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpPa04_RS02275	COG1321	iron dependent repressor
CpPa04_RS02280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CpPa04_RS02285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CpPa04_RS02320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS02325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CpPa04_RS02340	COG2838	Isocitrate dehydrogenase
CpPa04_RS02345	COG2814	Major facilitator Superfamily
CpPa04_RS02350	COG4978	Transcriptional regulator
CpPa04_RS02350	COG0789	Transcriptional regulator
CpPa04_RS02365	COG0180	Tryptophanyl-tRNA synthetase
CpPa04_RS02370	COG1295	ribonuclease BN
CpPa04_RS02375	COG1686	Belongs to the peptidase S11 family
CpPa04_RS02410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpPa04_RS02415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CpPa04_RS02415	COG1473	amidohydrolase
CpPa04_RS02430	COG2814	Major facilitator Superfamily
CpPa04_RS02440	COG4770	biotin carboxylase activity
CpPa04_RS02445	COG2897	thiosulfate sulfurtransferase activity
CpPa04_RS02450	COG0189	ligase activity
CpPa04_RS02455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpPa04_RS02455	COG2755	lipolytic protein G-D-S-L family
CpPa04_RS02465	COG0424	maF-like protein
CpPa04_RS02470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CpPa04_RS02475	COG1609	Transcriptional regulator
CpPa04_RS02485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpPa04_RS02490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpPa04_RS02495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CpPa04_RS02495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CpPa04_RS02545	COG1316	TRANSCRIPTIONal
CpPa04_RS02555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CpPa04_RS02590	COG1482	cell wall glycoprotein biosynthetic process
CpPa04_RS02615	COG0745	RESPONSE REGULATOR receiver
CpPa04_RS02620	COG5002	protein histidine kinase activity
CpPa04_RS02635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CpPa04_RS02675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CpPa04_RS02680	COG2135	peptidase activity
CpPa04_RS02685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CpPa04_RS02720	COG0513	Belongs to the DEAD box helicase family
CpPa04_RS02745	COG0210	DNA helicase
CpPa04_RS02755	COG2816	NAD+ diphosphatase activity
CpPa04_RS02780	COG3480	Lon protease (S16) C-terminal proteolytic domain
CpPa04_RS02905	COG0483	inositol monophosphate 1-phosphatase activity
CpPa04_RS02910	COG0483	inositol monophosphate 1-phosphatase activity
CpPa04_RS02925	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CpPa04_RS02935	COG2884	Cell division ATP-binding protein ftsE
CpPa04_RS02940	COG2177	Part of the ABC transporter FtsEX involved in
CpPa04_RS02955	COG0288	reversible hydration of carbon dioxide
CpPa04_RS03015	COG1061	Type III restriction enzyme res subunit
CpPa04_RS03030	COG1652	LysM domain
CpPa04_RS03055	COG2252	PERMEase
CpPa04_RS03060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpPa04_RS03080	COG0372	Belongs to the citrate synthase family
CpPa04_RS03085	COG0545	Peptidyl-prolyl cis-trans isomerase
CpPa04_RS03100	COG0656	L-ascorbic acid biosynthetic process
CpPa04_RS03105	COG1024	Enoyl-CoA hydratase
CpPa04_RS03115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpPa04_RS03125	COG3757	hydrolase, family 25
CpPa04_RS03140	COG0534	Mate efflux family protein
CpPa04_RS03145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CpPa04_RS03150	COG0019	diaminopimelate decarboxylase activity
CpPa04_RS03165	COG4166	transmembrane transport
CpPa04_RS03170	COG0601	transmembrane transport
CpPa04_RS03180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpPa04_RS03205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CpPa04_RS03220	COG1218	3'(2'),5'-bisphosphate nucleotidase
CpPa04_RS03230	COG1201	RNA secondary structure unwinding
CpPa04_RS03240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpPa04_RS03290	COG1126	abc transporter atp-binding protein
CpPa04_RS03295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpPa04_RS03300	COG0765	amino acid transport
CpPa04_RS03305	COG0765	amino acid transport
CpPa04_RS03315	COG1309	transcriptional regulator
CpPa04_RS03345	COG0254	rRNA binding
CpPa04_RS03355	COG0745	RESPONSE REGULATOR receiver
CpPa04_RS03360	COG2205	protein histidine kinase activity
CpPa04_RS03365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CpPa04_RS03370	COG0521	Mo-molybdopterin cofactor biosynthetic process
CpPa04_RS03370	COG0315	cyclic pyranopterin monophosphate synthase activity
CpPa04_RS03395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CpPa04_RS03415	COG2259	Doxx family
CpPa04_RS03425	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CpPa04_RS03435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpPa04_RS03440	COG3949	Membrane
CpPa04_RS03455	COG0084	hydrolase, TatD family'
CpPa04_RS03460	COG3583	domain protein
CpPa04_RS03475	COG0488	(ABC) transporter
CpPa04_RS03490	COG2326	polyphosphate kinase activity
CpPa04_RS03500	COG0561	phosphatase activity
CpPa04_RS03530	COG0596	Alpha beta hydrolase
CpPa04_RS03535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CpPa04_RS03545	COG0193	aminoacyl-tRNA hydrolase activity
CpPa04_RS03570	COG1523	belongs to the glycosyl hydrolase 13 family
CpPa04_RS03575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CpPa04_RS03580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CpPa04_RS03585	COG2132	Multicopper oxidase
CpPa04_RS03600	COG1309	transcriptional regulator
CpPa04_RS03610	COG0531	amino acid
CpPa04_RS03615	COG3956	TIGRFAM MazG family protein
CpPa04_RS03680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CpPa04_RS03750	COG0114	fumarate hydratase activity
CpPa04_RS03755	COG1494	fructose-1,6-bisphosphatase
CpPa04_RS03790	COG0012	GTP binding
CpPa04_RS03805	COG2824	Alkylphosphonate utilization operon protein PhnA
CpPa04_RS03810	COG1132	(ABC) transporter
CpPa04_RS03820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CpPa04_RS03825	COG2354	Protein conserved in bacteria
CpPa04_RS03835	COG4721	ABC-type cobalt transport system, permease component
CpPa04_RS03840	COG1122	ATPase activity
CpPa04_RS03850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CpPa04_RS03860	COG4166	transmembrane transport
CpPa04_RS03865	COG0601	transmembrane transport
CpPa04_RS03870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpPa04_RS03900	COG1217	gtp-binding protein TYPA
CpPa04_RS03905	COG4166	transmembrane transport
CpPa04_RS03940	COG1113	amino acid transport
CpPa04_RS03950	COG1113	amino acid transport
CpPa04_RS03960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpPa04_RS03965	COG1611	Belongs to the LOG family
CpPa04_RS03970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpPa04_RS03975	COG0463	Glycosyl transferase, family 2
CpPa04_RS04005	COG0297	glycogen (starch) synthase activity
CpPa04_RS04015	COG4122	O-methyltransferase activity
CpPa04_RS04045	COG2239	Acts as a magnesium transporter
CpPa04_RS04055	COG0567	Dehydrogenase, E1 component
CpPa04_RS04055	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpPa04_RS04060	COG1132	(ABC) transporter
CpPa04_RS04070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CpPa04_RS04075	COG2272	Belongs to the type-B carboxylesterase lipase family
CpPa04_RS04095	COG2017	converts alpha-aldose to the beta-anomer
CpPa04_RS04115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CpPa04_RS04150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CpPa04_RS04190	COG1349	DNA-binding transcription factor activity
CpPa04_RS04205	COG1556	Lactate utilization protein
CpPa04_RS04210	COG1139	Iron-sulfur cluster binding protein
CpPa04_RS04215	COG0247	lactate metabolic process
CpPa04_RS04220	COG1620	l-lactate permease
CpPa04_RS04230	COG0019	diaminopimelate decarboxylase activity
CpPa04_RS04235	COG0460	homoserine dehydrogenase
CpPa04_RS04285	COG0356	it plays a direct role in the translocation of protons across the membrane
CpPa04_RS04290	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CpPa04_RS04295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CpPa04_RS04340	COG0346	lactoylglutathione lyase activity
CpPa04_RS04365	COG1119	ATPase activity
CpPa04_RS04385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CpPa04_RS04450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS04455	COG1120	ATPase activity
CpPa04_RS04465	COG0205	6-phosphofructokinase activity
CpPa04_RS04475	COG0667	Aldo Keto reductase
CpPa04_RS04485	COG0583	DNA-binding transcription factor activity
CpPa04_RS04510	COG0668	transmembrane transport
CpPa04_RS04550	COG0473	3-isopropylmalate dehydrogenase activity
CpPa04_RS04570	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpPa04_RS04600	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpPa04_RS04655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CpPa04_RS04660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CpPa04_RS04665	COG1461	Dihydroxyacetone kinase
CpPa04_RS04675	COG0511	ligase activity, forming carbon-carbon bonds
CpPa04_RS04680	COG0742	ribosomal rna small subunit methyltransferase
CpPa04_RS04705	COG0765	amino acid transport
CpPa04_RS04730	COG2226	methyltransferase
CpPa04_RS04735	COG0539	negative regulation of cytoplasmic translation
CpPa04_RS04745	COG0237	dephospho-CoA kinase activity
CpPa04_RS04765	COG3973	AAA domain
CpPa04_RS04775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpPa04_RS04790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CpPa04_RS04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpPa04_RS04820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CpPa04_RS04835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CpPa04_RS04855	COG0165	Argininosuccinate lyase
CpPa04_RS04860	COG2835	tetraacyldisaccharide 4'-kinase activity
CpPa04_RS04895	COG0647	UMP catabolic process
CpPa04_RS04910	COG0497	DNA recombination
CpPa04_RS04925	COG0494	nUDIX hydrolase
CpPa04_RS04930	COG4974	Belongs to the 'phage' integrase family
CpPa04_RS04950	COG3104	oligopeptide transport
CpPa04_RS04955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CpPa04_RS04965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CpPa04_RS04980	COG1160	GTP binding
CpPa04_RS04995	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpPa04_RS05000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpPa04_RS05005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CpPa04_RS05010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS05015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS05020	COG1120	ATPase activity
CpPa04_RS05025	COG4264	IucA IucC family
CpPa04_RS05035	COG3547	Transposase (IS116 IS110 IS902 family)
CpPa04_RS05060	COG3012	SEC-C Motif Domain Protein
CpPa04_RS05070	COG0653	protein targeting
CpPa04_RS05110	COG1253	flavin adenine dinucleotide binding
CpPa04_RS05115	COG0513	Belongs to the DEAD box helicase family
CpPa04_RS05120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CpPa04_RS05130	COG0598	Magnesium transport protein CorA
CpPa04_RS05150	COG0477	Major facilitator Superfamily
CpPa04_RS05180	COG0463	Glycosyl transferase, family 2
CpPa04_RS05230	COG0300	oxidoreductase activity
CpPa04_RS05245	COG0805	protein transport
CpPa04_RS05255	COG2378	regulation of single-species biofilm formation
CpPa04_RS05275	COG4122	O-methyltransferase activity
CpPa04_RS05290	COG1362	aminopeptidase activity
CpPa04_RS05310	COG1027	Aspartate ammonia-lyase
CpPa04_RS05315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpPa04_RS05335	COG1410	methionine synthase
CpPa04_RS05335	COG0646	methionine synthase
CpPa04_RS05355	COG0667	Aldo Keto reductase
CpPa04_RS05365	COG0167	dihydroorotate dehydrogenase activity
CpPa04_RS05390	COG1461	Dihydroxyacetone kinase
CpPa04_RS05395	COG2376	Dihydroxyacetone kinase
CpPa04_RS05405	COG3842	ATPase activity
CpPa04_RS05410	COG0488	(ABC) transporter
CpPa04_RS05475	COG3883	PFAM NLP P60 protein
CpPa04_RS05475	COG0791	NLP P60 protein
CpPa04_RS05505	COG2848	UPF0210 protein
CpPa04_RS05525	COG0488	(ABC) transporter
CpPa04_RS05530	COG2151	metal-sulfur cluster biosynthetic enzyme
CpPa04_RS05535	COG0822	iron-sulfur transferase activity
CpPa04_RS05545	COG0396	ATPase activity
CpPa04_RS05590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CpPa04_RS05595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CpPa04_RS05615	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpPa04_RS05635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CpPa04_RS05645	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CpPa04_RS05655	COG0322	excinuclease ABC activity
CpPa04_RS05685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CpPa04_RS05700	COG0242	peptide deformylase activity
CpPa04_RS05740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CpPa04_RS05750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CpPa04_RS05765	COG1090	epimerase
CpPa04_RS05790	COG0006	proline dipeptidase activity
CpPa04_RS05795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CpPa04_RS05800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CpPa04_RS05805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CpPa04_RS05810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CpPa04_RS05830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CpPa04_RS05885	COG1760	l-serine dehydratase
CpPa04_RS05910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpPa04_RS05915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CpPa04_RS05930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CpPa04_RS05945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpPa04_RS05950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpPa04_RS05980	COG1946	Acyl-CoA thioesterase
CpPa04_RS05995	COG0156	8-amino-7-oxononanoate synthase activity
CpPa04_RS06010	COG1560	Kdo2-lipid A biosynthetic process
CpPa04_RS06015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CpPa04_RS06030	COG2837	iron assimilation
CpPa04_RS06085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CpPa04_RS06090	COG3253	May function as heme-dependent peroxidase
CpPa04_RS06175	COG2890	protein-(glutamine-N5) methyltransferase activity
CpPa04_RS06215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CpPa04_RS06220	COG0450	alkyl hydroperoxide reductase
CpPa04_RS06235	COG1643	Atp-dependent helicase
CpPa04_RS06255	COG1349	DNA-binding transcription factor activity
CpPa04_RS06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CpPa04_RS06265	COG1349	DNA-binding transcription factor activity
CpPa04_RS06270	COG1105	Belongs to the carbohydrate kinase PfkB family
CpPa04_RS06275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpPa04_RS06275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpPa04_RS06275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CpPa04_RS06285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpPa04_RS06290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpPa04_RS06300	COG2233	PERMEase
CpPa04_RS06305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CpPa04_RS06320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CpPa04_RS06335	COG1196	nuclear chromosome segregation
CpPa04_RS06355	COG2137	regulation of response to DNA damage stimulus
CpPa04_RS06360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CpPa04_RS06370	COG1268	BioY protein
CpPa04_RS06375	COG1122	ATPase activity
CpPa04_RS06385	COG1842	Phage shock protein A
CpPa04_RS06390	COG1396	sequence-specific DNA binding
CpPa04_RS06415	COG1674	ftsk spoiiie
CpPa04_RS06425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CpPa04_RS06465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CpPa04_RS06475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CpPa04_RS06480	COG0534	Mate efflux family protein
CpPa04_RS06525	COG3022	response to hydroperoxide
CpPa04_RS06530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpPa04_RS06530	COG1648	precorrin-2 dehydrogenase activity
CpPa04_RS06540	COG0523	cobalamin synthesis protein
CpPa04_RS06545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CpPa04_RS06545	COG2169	Transcriptional regulator
CpPa04_RS06610	COG0750	zinc metalloprotease
CpPa04_RS06670	COG4974	Belongs to the 'phage' integrase family
CpPa04_RS06700	COG0681	Belongs to the peptidase S26 family
CpPa04_RS06715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpPa04_RS06715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpPa04_RS06715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpPa04_RS06725	COG0336	Belongs to the RNA methyltransferase TrmD family
CpPa04_RS06730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CpPa04_RS06750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CpPa04_RS06780	COG1115	amino acid carrier protein
CpPa04_RS06785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpPa04_RS06810	COG0686	Belongs to the AlaDH PNT family
CpPa04_RS06815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CpPa04_RS06820	COG1929	Belongs to the glycerate kinase type-1 family
CpPa04_RS06845	COG0058	SHG alpha-glucan phosphorylase activity
CpPa04_RS06855	COG0469	pyruvate kinase activity
CpPa04_RS06865	COG0134	indole-3-glycerol-phosphate synthase activity
CpPa04_RS06885	COG0483	inositol monophosphate 1-phosphatase activity
CpPa04_RS06950	COG2176	DNA-directed DNA polymerase activity
CpPa04_RS06975	COG1739	Uncharacterized protein family UPF0029
CpPa04_RS06980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CpPa04_RS07005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CpPa04_RS07020	COG0252	asparaginase activity
CpPa04_RS07040	COG3599	regulation of cell shape
CpPa04_RS07050	COG1799	cell septum assembly
CpPa04_RS07060	COG1496	oxidoreductase activity
CpPa04_RS07065	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CpPa04_RS07075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CpPa04_RS07105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CpPa04_RS07110	COG0768	penicillin binding
CpPa04_RS07155	COG0142	geranyltranstransferase activity
CpPa04_RS07175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CpPa04_RS07195	COG1940	carbohydrate kinase activity
CpPa04_RS07200	COG0438	transferase activity, transferring glycosyl groups
CpPa04_RS07210	COG0791	NLP P60 protein
CpPa04_RS07260	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CpPa04_RS07265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CpPa04_RS07275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CpPa04_RS07290	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpPa04_RS07295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpPa04_RS07295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpPa04_RS07300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CpPa04_RS07305	COG0509	glycine decarboxylation via glycine cleavage system
CpPa04_RS07335	COG0174	glutamine synthetase
CpPa04_RS07480	COG2056	Na+-H+ antiporter family
CpPa04_RS07490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CpPa04_RS07515	COG0174	glutamine synthetase
CpPa04_RS07540	COG0557	exoribonuclease II activity
CpPa04_RS07560	COG3323	Protein of unknown function (DUF1653)
CpPa04_RS07560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CpPa04_RS07600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CpPa04_RS07605	COG0596	Alpha beta hydrolase
CpPa04_RS07630	COG2860	membrane
CpPa04_RS07700	COG0423	glycine-tRNA ligase activity
CpPa04_RS07730	COG1381	Involved in DNA repair and RecF pathway recombination
CpPa04_RS07785	COG1022	Amp-dependent synthetase and ligase
CpPa04_RS07830	COG1132	(ABC) transporter
CpPa04_RS07835	COG1114	Component of the transport system for branched-chain amino acids
CpPa04_RS07840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpPa04_RS07850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpPa04_RS07865	COG0747	negative chemotaxis
CpPa04_RS07870	COG0601	transmembrane transport
CpPa04_RS07875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpPa04_RS07880	COG4172	Belongs to the ABC transporter superfamily
CpPa04_RS07890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CpPa04_RS07895	COG2391	methyltransferase activity
CpPa04_RS07905	COG4171	peptide transport system, permease
CpPa04_RS07925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpPa04_RS07930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpPa04_RS07955	COG1280	lysine exporter protein (LysE YggA)
CpPa04_RS07980	COG1307	EDD domain protein, DegV family
CpPa04_RS07985	COG0406	alpha-ribazole phosphatase activity
CpPa04_RS07995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CpPa04_RS08010	COG2832	Protein of unknown function (DUF454)
CpPa04_RS08015	COG2985	domain, Protein
CpPa04_RS08015	COG0569	domain protein
CpPa04_RS08040	COG1530	ribonuclease E activity
CpPa04_RS08055	COG2423	ornithine cyclodeaminase activity
CpPa04_RS08065	COG0285	dihydrofolate synthase activity
CpPa04_RS08105	COG0544	peptidyl-prolyl cis-trans isomerase activity
CpPa04_RS08140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CpPa04_RS08150	COG0668	transmembrane transport
CpPa04_RS08230	COG1131	(ABC) transporter
CpPa04_RS08235	COG3336	cytochrome c oxidase
CpPa04_RS08240	COG1966	Carbon starvation protein
CpPa04_RS08260	COG0604	alcohol dehydrogenase
CpPa04_RS08285	COG1376	ErfK ybiS ycfS ynhG family protein
CpPa04_RS08295	COG2130	NADP-dependent
CpPa04_RS08300	COG1335	isochorismatase
CpPa04_RS08345	COG2197	response regulator
CpPa04_RS08395	COG1234	tRNA 3'-trailer cleavage
CpPa04_RS08420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CpPa04_RS08465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpPa04_RS08475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpPa04_RS08495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CpPa04_RS08565	COG0033	Phosphoglucomutase
CpPa04_RS08580	COG1136	(ABC) transporter
CpPa04_RS08580	COG0577	efflux transmembrane transporter activity
CpPa04_RS08585	COG0577	efflux transmembrane transporter activity
CpPa04_RS08585	COG1136	(ABC) transporter
CpPa04_RS08620	COG2197	response regulator
CpPa04_RS08635	COG1045	serine acetyltransferase
CpPa04_RS08655	COG0371	Dehydrogenase
CpPa04_RS08675	COG1271	oxidase subunit
CpPa04_RS08680	COG1294	oxidase, subunit
CpPa04_RS08685	COG4988	ABC transporter
CpPa04_RS08690	COG1132	(ABC) transporter
CpPa04_RS08715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CpPa04_RS08745	COG1597	lipid kinase activity
CpPa04_RS08760	COG0354	folic acid binding
CpPa04_RS08785	COG1780	Probably involved in ribonucleotide reductase function
CpPa04_RS08790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpPa04_RS08800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpPa04_RS08805	COG0047	phosphoribosylformylglycinamidine synthase activity
CpPa04_RS08810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpPa04_RS08815	COG0386	Belongs to the glutathione peroxidase family
CpPa04_RS08835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CpPa04_RS08840	COG0569	domain protein
CpPa04_RS08845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CpPa04_RS08850	COG0151	Belongs to the GarS family
CpPa04_RS08855	COG0537	adenosine 5'-monophosphoramidase activity
CpPa04_RS08865	COG2205	protein histidine kinase activity
CpPa04_RS08870	COG0745	RESPONSE REGULATOR receiver
CpPa04_RS08900	COG0028	Belongs to the TPP enzyme family
CpPa04_RS08945	COG1609	Transcriptional regulator
CpPa04_RS08955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpPa04_RS08975	COG1329	Transcriptional regulator
CpPa04_RS08980	COG2847	Copper chaperone PCu(A)C
CpPa04_RS08995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CpPa04_RS09005	COG0288	reversible hydration of carbon dioxide
CpPa04_RS09035	COG0477	Major facilitator Superfamily
CpPa04_RS09040	COG1957	nucleoside hydrolase
CpPa04_RS09055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpPa04_RS09070	COG1301	dicarboxylic acid transport
CpPa04_RS09075	COG1012	belongs to the aldehyde dehydrogenase family
CpPa04_RS09080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpPa04_RS09085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CpPa04_RS09090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CpPa04_RS09120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpPa04_RS09125	COG0302	gtp cyclohydrolase
CpPa04_RS09130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CpPa04_RS09135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CpPa04_RS09145	COG2027	D-alanyl-D-alanine carboxypeptidase
CpPa04_RS09150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CpPa04_RS09155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CpPa04_RS09155	COG0425	Belongs to the sulfur carrier protein TusA family
CpPa04_RS09160	COG1301	dicarboxylic acid transport
CpPa04_RS09180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CpPa04_RS09185	COG2326	polyphosphate kinase activity
CpPa04_RS09230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpPa04_RS09230	COG2111	Na H antiporter
CpPa04_RS09235	COG1006	Multisubunit Na H antiporter MnhC subunit
CpPa04_RS09240	COG0651	ATP synthesis coupled electron transport
CpPa04_RS09260	COG1051	belongs to the nudix hydrolase family
CpPa04_RS09280	COG0242	peptide deformylase activity
CpPa04_RS09285	COG0456	acetyltransferase
CpPa04_RS09295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CpPa04_RS09320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpPa04_RS09335	COG0280	phosphate acetyltransferase
CpPa04_RS09355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CpPa04_RS09390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpPa04_RS09395	COG1333	cytochrome c biogenesis protein
CpPa04_RS09405	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CpPa04_RS09410	COG3005	denitrification pathway
CpPa04_RS09425	COG4129	membrane
CpPa04_RS09470	COG0191	fructose-bisphosphate aldolase activity
CpPa04_RS09485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CpPa04_RS09540	COG1131	(ABC) transporter
CpPa04_RS09570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CpPa04_RS09590	COG1136	(ABC) transporter
CpPa04_RS09590	COG0577	efflux transmembrane transporter activity
CpPa04_RS09595	COG1136	(ABC) transporter
CpPa04_RS09600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CpPa04_RS09640	COG0789	Transcriptional regulator
CpPa04_RS09655	COG0443	Heat shock 70 kDa protein
CpPa04_RS09710	COG0247	lactate metabolic process
CpPa04_RS09710	COG2181	nitrate reductase activity
CpPa04_RS09725	COG1120	ATPase activity
CpPa04_RS09730	COG4139	cobalamin transport
CpPa04_RS09740	COG0829	nickel cation binding
CpPa04_RS09745	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CpPa04_RS09750	COG0830	nickel cation binding
CpPa04_RS09755	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CpPa04_RS09760	COG0804	urea catabolic process
CpPa04_RS09765	COG0832	Belongs to the urease beta subunit family
CpPa04_RS09770	COG0831	urea catabolic process
CpPa04_RS09795	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpPa04_RS09795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpPa04_RS09810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CpPa04_RS09825	COG1012	belongs to the aldehyde dehydrogenase family
CpPa04_RS09835	COG1472	Belongs to the glycosyl hydrolase 3 family
CpPa04_RS09845	COG4981	capsule polysaccharide biosynthetic process
CpPa04_RS09850	COG2755	lipolytic protein G-D-S-L family
CpPa04_RS09850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpPa04_RS09865	COG0438	transferase activity, transferring glycosyl groups
CpPa04_RS09870	COG0500	methyltransferase
CpPa04_RS09915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpPa04_RS09920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CpPa04_RS09920	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CpPa04_RS09920	COG3321	synthase
CpPa04_RS09925	COG0318	PFAM AMP-dependent synthetase and ligase
CpPa04_RS09930	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpPa04_RS09955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CpPa04_RS09965	COG1216	Glycosyl transferase, family 2
CpPa04_RS09975	COG0671	phosphoesterase, PA-phosphatase related
CpPa04_RS09985	COG0584	glycerophosphoryl diester phosphodiesterase
CpPa04_RS09990	COG2271	Major facilitator Superfamily
CpPa04_RS10005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpPa04_RS10010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpPa04_RS10020	COG0561	phosphatase activity
CpPa04_RS10035	COG2188	Transcriptional regulator
CpPa04_RS10060	COG0154	amidase activity
CpPa04_RS10070	COG1316	TRANSCRIPTIONal
CpPa04_RS10100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CpPa04_RS10130	COG0431	NADPH-dependent FMN reductase
CpPa04_RS10135	COG2814	Major facilitator Superfamily
CpPa04_RS10150	COG2271	Major facilitator Superfamily
CpPa04_RS10165	COG5650	phosphatidylinositol metabolic process
CpPa04_RS10185	COG2197	response regulator
CpPa04_RS10200	COG3764	Sortase (surface protein transpeptidase)
CpPa04_RS10205	COG0706	membrane insertase activity
CpPa04_RS10230	COG0564	pseudouridine synthase activity
CpPa04_RS10260	COG1131	(ABC) transporter
CpPa04_RS10275	COG1842	Phage shock protein A
CpPa04_RS10280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CpPa04_RS10295	COG0477	Major facilitator Superfamily
CpPa04_RS10300	COG0305	Participates in initiation and elongation during chromosome replication
CpPa04_RS10305	COG3387	PFAM Glycoside hydrolase 15-related
CpPa04_RS10320	COG0629	single-stranded DNA binding
CpPa04_RS10365	COG0300	oxidoreductase activity
CpPa04_RS10380	COG0586	Pfam SNARE associated Golgi protein
CpPa04_RS10385	COG0783	Belongs to the Dps family
CpPa04_RS10390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpPa04_RS10395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CpPa04_RS10395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CpPa04_RS10405	COG1511	domain protein
CpPa04_RS10415	COG1136	(ABC) transporter
CpPa04_RS10415	COG0577	efflux transmembrane transporter activity
CpPa04_RS10435	COG4585	Histidine kinase
CpPa04_RS10440	COG2197	response regulator
CpPa04_RS10455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CpPa04_RS10470	COG2186	Transcriptional regulator
CpPa04_RS10475	COG0747	negative chemotaxis
CpPa04_RS10480	COG0601	transmembrane transport
CpPa04_RS10485	COG0444	Belongs to the ABC transporter superfamily
CpPa04_RS10490	COG4608	Belongs to the ABC transporter superfamily
CpPa04_RS10495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CpPa04_RS10535	COG3422	double-strand break repair
CpPa04_RS10550	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CpPa04_RS10570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CpPa04_RS10575	COG0512	Glutamine amidotransferase of anthranilate synthase
CpPa04_RS10585	COG0134	indole-3-glycerol-phosphate synthase activity
CpPa04_RS10585	COG0135	phosphoribosylanthranilate isomerase activity
CpPa04_RS10620	COG1687	branched-chain amino acid
CpPa04_RS10625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CpPa04_RS10630	COG1678	Uncharacterized ACR, COG1678
CpPa04_RS10635	COG0617	tRNA 3'-terminal CCA addition
CpPa04_RS10670	COG0860	N-Acetylmuramoyl-L-alanine amidase
CpPa04_RS10670	COG3409	Peptidoglycan-binding domain 1 protein
CpPa04_RS10685	COG1192	Involved in chromosome partitioning
CpPa04_RS10700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CpPa04_RS10710	COG0230	Belongs to the bacterial ribosomal protein bL34 family