locus-tag	class	description
CPSIGH_RS00015	COG0592	DNA-directed DNA polymerase activity
CPSIGH_RS00030	COG0187	DNA topoisomerase II activity
CPSIGH_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPSIGH_RS00140	COG1120	ATPase activity
CPSIGH_RS00145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS00150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS00155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPSIGH_RS00165	COG0515	serine threonine protein kinase
CPSIGH_RS00165	COG2815	serine threonine protein kinase
CPSIGH_RS00170	COG0515	serine threonine protein kinase
CPSIGH_RS00175	COG0768	penicillin binding
CPSIGH_RS00195	COG1716	ATPase activity
CPSIGH_RS00195	COG1716	ATPase activity
CPSIGH_RS00225	COG1120	ATPase activity
CPSIGH_RS00230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS00235	COG2239	Acts as a magnesium transporter
CPSIGH_RS00240	COG0366	Alpha amylase catalytic
CPSIGH_RS00295	COG0517	IMP dehydrogenase activity
CPSIGH_RS00295	COG1125	glycine betaine transport
CPSIGH_RS00305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPSIGH_RS00325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPSIGH_RS00335	COG3757	hydrolase, family 25
CPSIGH_RS00335	COG3409	Peptidoglycan-binding domain 1 protein
CPSIGH_RS00360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CPSIGH_RS00385	COG1846	Transcriptional regulator
CPSIGH_RS00400	COG3180	Ammonia monooxygenase
CPSIGH_RS00410	COG0730	response to heat
CPSIGH_RS00425	COG1643	Atp-dependent helicase
CPSIGH_RS00435	COG0519	Catalyzes the synthesis of GMP from XMP
CPSIGH_RS00445	COG0393	Putative heavy-metal-binding
CPSIGH_RS00450	COG2501	S4 domain
CPSIGH_RS00475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPSIGH_RS00480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPSIGH_RS00490	COG3590	peptidase
CPSIGH_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
CPSIGH_RS00525	COG0277	FAD linked oxidase domain protein
CPSIGH_RS00555	COG1216	Glycosyl transferase, family 2
CPSIGH_RS00565	COG1121	(ABC) transporter
CPSIGH_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPSIGH_RS00575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPSIGH_RS00580	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPSIGH_RS00605	COG0604	alcohol dehydrogenase
CPSIGH_RS00630	COG0471	metal ion transport
CPSIGH_RS00640	COG1263	PTS System
CPSIGH_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPSIGH_RS00645	COG2190	(PTS) system
CPSIGH_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPSIGH_RS00645	COG1263	PTS System
CPSIGH_RS00670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPSIGH_RS00685	COG0287	Prephenate dehydrogenase
CPSIGH_RS00705	COG2409	Drug exporters of the RND superfamily
CPSIGH_RS00710	COG0343	queuine tRNA-ribosyltransferase activity
CPSIGH_RS00720	COG2610	gluconate transmembrane transporter activity
CPSIGH_RS00725	COG3265	gluconokinase activity
CPSIGH_RS00730	COG1063	alcohol dehydrogenase
CPSIGH_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
CPSIGH_RS00750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPSIGH_RS00775	COG2610	gluconate transmembrane transporter activity
CPSIGH_RS00780	COG2084	Dehydrogenase
CPSIGH_RS00795	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPSIGH_RS00805	COG3442	glutamine amidotransferase
CPSIGH_RS00810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPSIGH_RS00825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPSIGH_RS00830	COG2390	Transcriptional regulator
CPSIGH_RS00835	COG0813	purine-nucleoside phosphorylase activity
CPSIGH_RS00850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPSIGH_RS00875	COG0697	spore germination
CPSIGH_RS00880	COG0527	aspartate kinase activity
CPSIGH_RS00940	COG1840	ABC-type Fe3 transport system, periplasmic component
CPSIGH_RS00945	COG2271	Major facilitator Superfamily
CPSIGH_RS00955	COG3852	Histidine kinase
CPSIGH_RS00975	COG0651	ATP synthesis coupled electron transport
CPSIGH_RS00985	COG2111	Na H antiporter
CPSIGH_RS00985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPSIGH_RS01005	COG4152	abc transporter atp-binding protein
CPSIGH_RS01035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPSIGH_RS01060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPSIGH_RS01080	COG0494	nUDIX hydrolase
CPSIGH_RS01150	COG1111	helicase
CPSIGH_RS01150	COG1205	dead DEAH box helicase
CPSIGH_RS01160	COG1754	DNA topoisomerase type I activity
CPSIGH_RS01160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPSIGH_RS01165	COG1297	OPT oligopeptide transporter protein
CPSIGH_RS01175	COG0470	DNA polymerase III
CPSIGH_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
CPSIGH_RS01200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CPSIGH_RS01210	COG1088	dTDP-glucose 4,6-dehydratase activity
CPSIGH_RS01220	COG1505	serine-type exopeptidase activity
CPSIGH_RS01235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPSIGH_RS01240	COG3800	Transcriptional regulator
CPSIGH_RS01240	COG1396	sequence-specific DNA binding
CPSIGH_RS01250	COG1053	succinate dehydrogenase
CPSIGH_RS01255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CPSIGH_RS01265	COG2733	membrane
CPSIGH_RS01275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CPSIGH_RS01295	COG1882	Formate acetyltransferase
CPSIGH_RS01315	COG0318	PFAM AMP-dependent synthetase and ligase
CPSIGH_RS01330	COG5002	protein histidine kinase activity
CPSIGH_RS01335	COG0745	RESPONSE REGULATOR receiver
CPSIGH_RS01355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPSIGH_RS01375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CPSIGH_RS01375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPSIGH_RS01405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPSIGH_RS01405	COG1648	precorrin-2 dehydrogenase activity
CPSIGH_RS01420	COG2217	Heavy metal translocating P-type atpase
CPSIGH_RS01430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CPSIGH_RS01445	COG0406	alpha-ribazole phosphatase activity
CPSIGH_RS01455	COG0785	Cytochrome C biogenesis protein
CPSIGH_RS01465	COG0275	rRNA processing
CPSIGH_RS01480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS01485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPSIGH_RS01515	COG3069	C4-dicarboxylate transmembrane transporter activity
CPSIGH_RS01520	COG4948	Mandelate Racemase Muconate Lactonizing
CPSIGH_RS01535	COG0438	transferase activity, transferring glycosyl groups
CPSIGH_RS01535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPSIGH_RS01545	COG0039	L-malate dehydrogenase activity
CPSIGH_RS01550	COG0644	oxidoreductase
CPSIGH_RS01555	COG0142	geranyltranstransferase activity
CPSIGH_RS01580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPSIGH_RS01605	COG3579	cysteine-type endopeptidase activity
CPSIGH_RS01610	COG1902	pentaerythritol trinitrate reductase activity
CPSIGH_RS01630	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPSIGH_RS01640	COG1121	(ABC) transporter
CPSIGH_RS01645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPSIGH_RS01675	COG2197	response regulator
CPSIGH_RS01685	COG1131	(ABC) transporter
CPSIGH_RS01700	COG0701	Predicted permease
CPSIGH_RS01770	COG1302	Protein conserved in bacteria
CPSIGH_RS01865	COG0814	amino acid
CPSIGH_RS01870	COG1760	l-serine dehydratase
CPSIGH_RS01875	COG0252	asparaginase activity
CPSIGH_RS01925	COG1175	transmembrane transport
CPSIGH_RS01930	COG3833	ABC-type maltose transport systems, permease component
CPSIGH_RS01950	COG3842	ATPase activity
CPSIGH_RS01955	COG0201	protein transport
CPSIGH_RS02005	COG0203	ribosomal protein L17
CPSIGH_RS02025	COG1404	Belongs to the peptidase S8 family
CPSIGH_RS02035	COG1674	ftsk spoiiie
CPSIGH_RS02090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPSIGH_RS02160	COG0516	GMP reductase activity
CPSIGH_RS02205	COG2011	ABC-type metal ion transport system permease component
CPSIGH_RS02215	COG1464	Belongs to the NlpA lipoprotein family
CPSIGH_RS02220	COG1464	Belongs to the NlpA lipoprotein family
CPSIGH_RS02235	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPSIGH_RS02240	COG1121	(ABC) transporter
CPSIGH_RS02250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPSIGH_RS02250	COG1321	iron dependent repressor
CPSIGH_RS02255	COG1321	iron dependent repressor
CPSIGH_RS02260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CPSIGH_RS02265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CPSIGH_RS02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS02305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CPSIGH_RS02320	COG2838	Isocitrate dehydrogenase
CPSIGH_RS02325	COG2814	Major facilitator Superfamily
CPSIGH_RS02330	COG4978	Transcriptional regulator
CPSIGH_RS02330	COG0789	Transcriptional regulator
CPSIGH_RS02345	COG0180	Tryptophanyl-tRNA synthetase
CPSIGH_RS02350	COG1295	ribonuclease BN
CPSIGH_RS02355	COG1686	Belongs to the peptidase S11 family
CPSIGH_RS02390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPSIGH_RS02395	COG1473	amidohydrolase
CPSIGH_RS02395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CPSIGH_RS02410	COG2814	Major facilitator Superfamily
CPSIGH_RS02420	COG4770	biotin carboxylase activity
CPSIGH_RS02425	COG2897	thiosulfate sulfurtransferase activity
CPSIGH_RS02435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPSIGH_RS02435	COG2755	lipolytic protein G-D-S-L family
CPSIGH_RS02445	COG0424	maF-like protein
CPSIGH_RS02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPSIGH_RS02455	COG1609	Transcriptional regulator
CPSIGH_RS02465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPSIGH_RS02470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPSIGH_RS02475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CPSIGH_RS02475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CPSIGH_RS02525	COG1316	TRANSCRIPTIONal
CPSIGH_RS02535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CPSIGH_RS02570	COG1482	cell wall glycoprotein biosynthetic process
CPSIGH_RS02595	COG0745	RESPONSE REGULATOR receiver
CPSIGH_RS02600	COG5002	protein histidine kinase activity
CPSIGH_RS02615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CPSIGH_RS02655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CPSIGH_RS02660	COG2135	peptidase activity
CPSIGH_RS02665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPSIGH_RS02730	COG0513	Belongs to the DEAD box helicase family
CPSIGH_RS02755	COG0210	DNA helicase
CPSIGH_RS02765	COG2816	NAD+ diphosphatase activity
CPSIGH_RS02790	COG3480	Lon protease (S16) C-terminal proteolytic domain
CPSIGH_RS02915	COG0483	inositol monophosphate 1-phosphatase activity
CPSIGH_RS02920	COG0483	inositol monophosphate 1-phosphatase activity
CPSIGH_RS02935	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CPSIGH_RS02945	COG2884	Cell division ATP-binding protein ftsE
CPSIGH_RS02950	COG2177	Part of the ABC transporter FtsEX involved in
CPSIGH_RS02965	COG0288	reversible hydration of carbon dioxide
CPSIGH_RS03010	COG0564	pseudouridine synthase activity
CPSIGH_RS03035	COG0706	membrane insertase activity
CPSIGH_RS03040	COG3764	Sortase (surface protein transpeptidase)
CPSIGH_RS03055	COG2197	response regulator
CPSIGH_RS03075	COG5650	phosphatidylinositol metabolic process
CPSIGH_RS03085	COG2271	Major facilitator Superfamily
CPSIGH_RS03095	COG2814	Major facilitator Superfamily
CPSIGH_RS03100	COG0431	NADPH-dependent FMN reductase
CPSIGH_RS03130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPSIGH_RS03160	COG1316	TRANSCRIPTIONal
CPSIGH_RS03170	COG0154	amidase activity
CPSIGH_RS03195	COG2188	Transcriptional regulator
CPSIGH_RS03210	COG0561	phosphatase activity
CPSIGH_RS03220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPSIGH_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS03240	COG2271	Major facilitator Superfamily
CPSIGH_RS03245	COG0584	glycerophosphoryl diester phosphodiesterase
CPSIGH_RS03255	COG0671	phosphoesterase, PA-phosphatase related
CPSIGH_RS03265	COG1216	Glycosyl transferase, family 2
CPSIGH_RS03270	COG0671	phosphoesterase, PA-phosphatase related
CPSIGH_RS03275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CPSIGH_RS03280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CPSIGH_RS03295	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPSIGH_RS03295	COG5479	isomerase activity
CPSIGH_RS03305	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CPSIGH_RS03310	COG0318	PFAM AMP-dependent synthetase and ligase
CPSIGH_RS03315	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CPSIGH_RS03315	COG3321	synthase
CPSIGH_RS03315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPSIGH_RS03320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPSIGH_RS03365	COG0500	methyltransferase
CPSIGH_RS03370	COG0438	transferase activity, transferring glycosyl groups
CPSIGH_RS03385	COG2755	lipolytic protein G-D-S-L family
CPSIGH_RS03385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPSIGH_RS03390	COG4981	capsule polysaccharide biosynthetic process
CPSIGH_RS03400	COG1472	Belongs to the glycosyl hydrolase 3 family
CPSIGH_RS03410	COG1012	belongs to the aldehyde dehydrogenase family
CPSIGH_RS03425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CPSIGH_RS03445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPSIGH_RS03445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPSIGH_RS03470	COG0831	urea catabolic process
CPSIGH_RS03475	COG0832	Belongs to the urease beta subunit family
CPSIGH_RS03480	COG0804	urea catabolic process
CPSIGH_RS03485	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CPSIGH_RS03490	COG0830	nickel cation binding
CPSIGH_RS03495	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CPSIGH_RS03500	COG0829	nickel cation binding
CPSIGH_RS03510	COG4139	cobalamin transport
CPSIGH_RS03515	COG1120	ATPase activity
CPSIGH_RS03530	COG2181	nitrate reductase activity
CPSIGH_RS03530	COG0247	lactate metabolic process
CPSIGH_RS03555	COG0601	transmembrane transport
CPSIGH_RS03590	COG0443	Heat shock 70 kDa protein
CPSIGH_RS03605	COG0789	Transcriptional regulator
CPSIGH_RS03645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPSIGH_RS03650	COG1136	(ABC) transporter
CPSIGH_RS03655	COG0577	efflux transmembrane transporter activity
CPSIGH_RS03655	COG1136	(ABC) transporter
CPSIGH_RS03675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPSIGH_RS03705	COG1131	(ABC) transporter
CPSIGH_RS03745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CPSIGH_RS03760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CPSIGH_RS03775	COG0191	fructose-bisphosphate aldolase activity
CPSIGH_RS03820	COG4129	membrane
CPSIGH_RS03835	COG3005	denitrification pathway
CPSIGH_RS03840	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CPSIGH_RS03850	COG1333	cytochrome c biogenesis protein
CPSIGH_RS03855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPSIGH_RS03885	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CPSIGH_RS03890	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CPSIGH_RS03910	COG0280	phosphate acetyltransferase
CPSIGH_RS03925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPSIGH_RS03950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPSIGH_RS03960	COG0456	acetyltransferase
CPSIGH_RS03965	COG0242	peptide deformylase activity
CPSIGH_RS03985	COG1051	belongs to the nudix hydrolase family
CPSIGH_RS04005	COG0651	ATP synthesis coupled electron transport
CPSIGH_RS04010	COG1006	Multisubunit Na H antiporter MnhC subunit
CPSIGH_RS04015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPSIGH_RS04015	COG2111	Na H antiporter
CPSIGH_RS04055	COG2326	polyphosphate kinase activity
CPSIGH_RS04060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CPSIGH_RS04080	COG1301	dicarboxylic acid transport
CPSIGH_RS04085	COG0425	Belongs to the sulfur carrier protein TusA family
CPSIGH_RS04085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPSIGH_RS04090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CPSIGH_RS04095	COG2027	D-alanyl-D-alanine carboxypeptidase
CPSIGH_RS04105	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CPSIGH_RS04110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPSIGH_RS04115	COG0302	gtp cyclohydrolase
CPSIGH_RS04120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPSIGH_RS04150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPSIGH_RS04155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CPSIGH_RS04160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPSIGH_RS04165	COG1012	belongs to the aldehyde dehydrogenase family
CPSIGH_RS04170	COG1301	dicarboxylic acid transport
CPSIGH_RS04185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPSIGH_RS04200	COG1957	nucleoside hydrolase
CPSIGH_RS04205	COG0477	Major facilitator Superfamily
CPSIGH_RS04215	COG0542	response to heat
CPSIGH_RS04235	COG0288	reversible hydration of carbon dioxide
CPSIGH_RS04245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPSIGH_RS04260	COG2847	Copper chaperone PCu(A)C
CPSIGH_RS04265	COG1329	Transcriptional regulator
CPSIGH_RS04285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPSIGH_RS04295	COG1609	Transcriptional regulator
CPSIGH_RS04340	COG0028	Belongs to the TPP enzyme family
CPSIGH_RS04370	COG0745	RESPONSE REGULATOR receiver
CPSIGH_RS04375	COG2205	protein histidine kinase activity
CPSIGH_RS04385	COG0537	adenosine 5'-monophosphoramidase activity
CPSIGH_RS04390	COG0151	Belongs to the GarS family
CPSIGH_RS04395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPSIGH_RS04400	COG0569	domain protein
CPSIGH_RS04405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPSIGH_RS04425	COG0386	Belongs to the glutathione peroxidase family
CPSIGH_RS04430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPSIGH_RS04435	COG0047	phosphoribosylformylglycinamidine synthase activity
CPSIGH_RS04440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPSIGH_RS04450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPSIGH_RS04455	COG1780	Probably involved in ribonucleotide reductase function
CPSIGH_RS04480	COG0354	folic acid binding
CPSIGH_RS04495	COG1597	lipid kinase activity
CPSIGH_RS04525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPSIGH_RS04550	COG1132	(ABC) transporter
CPSIGH_RS04555	COG4988	ABC transporter
CPSIGH_RS04560	COG1294	oxidase, subunit
CPSIGH_RS04565	COG1271	oxidase subunit
CPSIGH_RS04605	COG1045	serine acetyltransferase
CPSIGH_RS04620	COG2197	response regulator
CPSIGH_RS04655	COG0577	efflux transmembrane transporter activity
CPSIGH_RS04655	COG1136	(ABC) transporter
CPSIGH_RS04660	COG1136	(ABC) transporter
CPSIGH_RS04660	COG0577	efflux transmembrane transporter activity
CPSIGH_RS04675	COG0033	Phosphoglucomutase
CPSIGH_RS04740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CPSIGH_RS04760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPSIGH_RS04770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPSIGH_RS04815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPSIGH_RS04840	COG1234	tRNA 3'-trailer cleavage
CPSIGH_RS04890	COG2197	response regulator
CPSIGH_RS04935	COG1335	isochorismatase
CPSIGH_RS04940	COG2130	NADP-dependent
CPSIGH_RS04950	COG1376	ErfK ybiS ycfS ynhG family protein
CPSIGH_RS04975	COG0604	alcohol dehydrogenase
CPSIGH_RS04995	COG1966	Carbon starvation protein
CPSIGH_RS05000	COG3336	cytochrome c oxidase
CPSIGH_RS05005	COG1131	(ABC) transporter
CPSIGH_RS05085	COG0668	transmembrane transport
CPSIGH_RS05095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CPSIGH_RS05130	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPSIGH_RS05170	COG0285	dihydrofolate synthase activity
CPSIGH_RS05180	COG2423	ornithine cyclodeaminase activity
CPSIGH_RS05195	COG1530	ribonuclease E activity
CPSIGH_RS05220	COG2985	domain, Protein
CPSIGH_RS05220	COG0569	domain protein
CPSIGH_RS05225	COG2832	Protein of unknown function (DUF454)
CPSIGH_RS05240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPSIGH_RS05250	COG0406	alpha-ribazole phosphatase activity
CPSIGH_RS05255	COG1307	EDD domain protein, DegV family
CPSIGH_RS05280	COG1280	lysine exporter protein (LysE YggA)
CPSIGH_RS05305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPSIGH_RS05310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPSIGH_RS05330	COG0601	transmembrane transport
CPSIGH_RS05340	COG2391	methyltransferase activity
CPSIGH_RS05345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPSIGH_RS05355	COG4172	Belongs to the ABC transporter superfamily
CPSIGH_RS05360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPSIGH_RS05365	COG0601	transmembrane transport
CPSIGH_RS05370	COG0747	negative chemotaxis
CPSIGH_RS05385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPSIGH_RS05395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPSIGH_RS05400	COG1114	Component of the transport system for branched-chain amino acids
CPSIGH_RS05455	COG1022	Amp-dependent synthetase and ligase
CPSIGH_RS05510	COG1381	Involved in DNA repair and RecF pathway recombination
CPSIGH_RS05540	COG0423	glycine-tRNA ligase activity
CPSIGH_RS05610	COG2860	membrane
CPSIGH_RS05640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CPSIGH_RS05680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CPSIGH_RS05680	COG3323	Protein of unknown function (DUF1653)
CPSIGH_RS05700	COG0557	exoribonuclease II activity
CPSIGH_RS05725	COG0174	glutamine synthetase
CPSIGH_RS05750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CPSIGH_RS05760	COG2056	Na+-H+ antiporter family
CPSIGH_RS05910	COG0174	glutamine synthetase
CPSIGH_RS05940	COG0509	glycine decarboxylation via glycine cleavage system
CPSIGH_RS05945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CPSIGH_RS05950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPSIGH_RS05950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPSIGH_RS05970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPSIGH_RS05980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CPSIGH_RS05985	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CPSIGH_RS06035	COG0791	NLP P60 protein
CPSIGH_RS06045	COG0438	transferase activity, transferring glycosyl groups
CPSIGH_RS06050	COG1940	carbohydrate kinase activity
CPSIGH_RS06070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CPSIGH_RS06075	COG0515	serine threonine protein kinase
CPSIGH_RS06075	COG2815	serine threonine protein kinase
CPSIGH_RS06090	COG0142	geranyltranstransferase activity
CPSIGH_RS06135	COG0768	penicillin binding
CPSIGH_RS06140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPSIGH_RS06170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPSIGH_RS06180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CPSIGH_RS06185	COG1496	oxidoreductase activity
CPSIGH_RS06190	COG1799	cell septum assembly
CPSIGH_RS06200	COG3599	regulation of cell shape
CPSIGH_RS06220	COG0252	asparaginase activity
CPSIGH_RS06235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CPSIGH_RS06260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPSIGH_RS06265	COG1739	Uncharacterized protein family UPF0029
CPSIGH_RS06290	COG2176	DNA-directed DNA polymerase activity
CPSIGH_RS06355	COG0483	inositol monophosphate 1-phosphatase activity
CPSIGH_RS06375	COG0134	indole-3-glycerol-phosphate synthase activity
CPSIGH_RS06385	COG0469	pyruvate kinase activity
CPSIGH_RS06395	COG0058	SHG alpha-glucan phosphorylase activity
CPSIGH_RS06420	COG1929	Belongs to the glycerate kinase type-1 family
CPSIGH_RS06425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPSIGH_RS06430	COG0686	Belongs to the AlaDH PNT family
CPSIGH_RS06455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPSIGH_RS06460	COG1115	amino acid carrier protein
CPSIGH_RS06490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CPSIGH_RS06510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CPSIGH_RS06515	COG0336	Belongs to the RNA methyltransferase TrmD family
CPSIGH_RS06525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPSIGH_RS06525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPSIGH_RS06525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPSIGH_RS06540	COG0681	Belongs to the peptidase S26 family
CPSIGH_RS06565	COG4974	Belongs to the 'phage' integrase family
CPSIGH_RS06620	COG0750	zinc metalloprotease
CPSIGH_RS06685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPSIGH_RS06685	COG2169	Transcriptional regulator
CPSIGH_RS06690	COG0523	cobalamin synthesis protein
CPSIGH_RS06695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CPSIGH_RS06700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPSIGH_RS06700	COG1648	precorrin-2 dehydrogenase activity
CPSIGH_RS06705	COG3022	response to hydroperoxide
CPSIGH_RS06750	COG0534	Mate efflux family protein
CPSIGH_RS06755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CPSIGH_RS06765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPSIGH_RS06805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPSIGH_RS06815	COG1674	ftsk spoiiie
CPSIGH_RS06840	COG1396	sequence-specific DNA binding
CPSIGH_RS06845	COG1842	Phage shock protein A
CPSIGH_RS06855	COG1122	ATPase activity
CPSIGH_RS06860	COG1268	BioY protein
CPSIGH_RS06870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CPSIGH_RS06875	COG2137	regulation of response to DNA damage stimulus
CPSIGH_RS06895	COG1196	nuclear chromosome segregation
CPSIGH_RS06910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CPSIGH_RS06925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPSIGH_RS06930	COG2233	PERMEase
CPSIGH_RS06940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPSIGH_RS06945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPSIGH_RS06955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPSIGH_RS06955	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CPSIGH_RS06955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPSIGH_RS06960	COG1105	Belongs to the carbohydrate kinase PfkB family
CPSIGH_RS06965	COG1349	DNA-binding transcription factor activity
CPSIGH_RS06970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPSIGH_RS06975	COG1349	DNA-binding transcription factor activity
CPSIGH_RS07000	COG1643	Atp-dependent helicase
CPSIGH_RS07015	COG0450	alkyl hydroperoxide reductase
CPSIGH_RS07020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPSIGH_RS07060	COG2890	protein-(glutamine-N5) methyltransferase activity
CPSIGH_RS07145	COG3253	May function as heme-dependent peroxidase
CPSIGH_RS07150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPSIGH_RS07205	COG2837	iron assimilation
CPSIGH_RS07220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPSIGH_RS07225	COG1560	Kdo2-lipid A biosynthetic process
CPSIGH_RS07240	COG0156	8-amino-7-oxononanoate synthase activity
CPSIGH_RS07255	COG1946	Acyl-CoA thioesterase
CPSIGH_RS07285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPSIGH_RS07290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPSIGH_RS07305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPSIGH_RS07320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CPSIGH_RS07325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPSIGH_RS07350	COG1760	l-serine dehydratase
CPSIGH_RS07405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPSIGH_RS07425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CPSIGH_RS07430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CPSIGH_RS07435	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CPSIGH_RS07440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPSIGH_RS07445	COG0006	proline dipeptidase activity
CPSIGH_RS07470	COG1090	epimerase
CPSIGH_RS07485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPSIGH_RS07495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPSIGH_RS07540	COG0242	peptide deformylase activity
CPSIGH_RS07555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPSIGH_RS07585	COG0322	excinuclease ABC activity
CPSIGH_RS07595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CPSIGH_RS07605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPSIGH_RS07625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPSIGH_RS07645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPSIGH_RS07650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPSIGH_RS07695	COG0396	ATPase activity
CPSIGH_RS07705	COG0822	iron-sulfur transferase activity
CPSIGH_RS07710	COG2151	metal-sulfur cluster biosynthetic enzyme
CPSIGH_RS07735	COG2848	UPF0210 protein
CPSIGH_RS07765	COG3883	PFAM NLP P60 protein
CPSIGH_RS07765	COG0791	NLP P60 protein
CPSIGH_RS07830	COG0488	(ABC) transporter
CPSIGH_RS07835	COG3842	ATPase activity
CPSIGH_RS07845	COG2376	Dihydroxyacetone kinase
CPSIGH_RS07850	COG1461	Dihydroxyacetone kinase
CPSIGH_RS07875	COG0167	dihydroorotate dehydrogenase activity
CPSIGH_RS07885	COG0667	Aldo Keto reductase
CPSIGH_RS07905	COG0646	methionine synthase
CPSIGH_RS07905	COG1410	methionine synthase
CPSIGH_RS07925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CPSIGH_RS07930	COG1027	Aspartate ammonia-lyase
CPSIGH_RS07950	COG1362	aminopeptidase activity
CPSIGH_RS07965	COG4122	O-methyltransferase activity
CPSIGH_RS07985	COG2378	regulation of single-species biofilm formation
CPSIGH_RS07995	COG0805	protein transport
CPSIGH_RS08010	COG0300	oxidoreductase activity
CPSIGH_RS08060	COG0463	Glycosyl transferase, family 2
CPSIGH_RS08085	COG0477	Major facilitator Superfamily
CPSIGH_RS08105	COG0598	Magnesium transport protein CorA
CPSIGH_RS08115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CPSIGH_RS08120	COG0513	Belongs to the DEAD box helicase family
CPSIGH_RS08125	COG1253	flavin adenine dinucleotide binding
CPSIGH_RS08165	COG0653	protein targeting
CPSIGH_RS08175	COG3012	SEC-C Motif Domain Protein
CPSIGH_RS08200	COG3547	Transposase (IS116 IS110 IS902 family)
CPSIGH_RS08210	COG4264	IucA IucC family
CPSIGH_RS08215	COG1120	ATPase activity
CPSIGH_RS08220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS08225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS08230	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CPSIGH_RS08235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPSIGH_RS08240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPSIGH_RS08245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CPSIGH_RS08250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CPSIGH_RS08255	COG1160	GTP binding
CPSIGH_RS08270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPSIGH_RS08280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CPSIGH_RS08285	COG3104	oligopeptide transport
CPSIGH_RS08305	COG4974	Belongs to the 'phage' integrase family
CPSIGH_RS08310	COG0494	nUDIX hydrolase
CPSIGH_RS08340	COG0647	UMP catabolic process
CPSIGH_RS08375	COG2835	tetraacyldisaccharide 4'-kinase activity
CPSIGH_RS08380	COG0165	Argininosuccinate lyase
CPSIGH_RS08400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CPSIGH_RS08415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CPSIGH_RS08430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPSIGH_RS08445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPSIGH_RS08460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPSIGH_RS08470	COG3973	AAA domain
CPSIGH_RS08490	COG0237	dephospho-CoA kinase activity
CPSIGH_RS08500	COG0539	negative regulation of cytoplasmic translation
CPSIGH_RS08505	COG2226	methyltransferase
CPSIGH_RS08530	COG0765	amino acid transport
CPSIGH_RS08555	COG0742	ribosomal rna small subunit methyltransferase
CPSIGH_RS08560	COG0511	ligase activity, forming carbon-carbon bonds
CPSIGH_RS08570	COG1461	Dihydroxyacetone kinase
CPSIGH_RS08575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CPSIGH_RS08580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CPSIGH_RS08600	COG0406	alpha-ribazole phosphatase activity
CPSIGH_RS08600	COG0494	nUDIX hydrolase
CPSIGH_RS08655	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPSIGH_RS08675	COG0473	3-isopropylmalate dehydrogenase activity
CPSIGH_RS08715	COG0668	transmembrane transport
CPSIGH_RS08740	COG0583	DNA-binding transcription factor activity
CPSIGH_RS08750	COG0667	Aldo Keto reductase
CPSIGH_RS08760	COG0205	6-phosphofructokinase activity
CPSIGH_RS08770	COG1120	ATPase activity
CPSIGH_RS08775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPSIGH_RS08840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CPSIGH_RS08860	COG1119	ATPase activity
CPSIGH_RS08885	COG0346	lactoylglutathione lyase activity
CPSIGH_RS08930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPSIGH_RS08935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPSIGH_RS08940	COG0356	it plays a direct role in the translocation of protons across the membrane
CPSIGH_RS08990	COG0460	homoserine dehydrogenase
CPSIGH_RS08995	COG0019	diaminopimelate decarboxylase activity
CPSIGH_RS09005	COG1620	l-lactate permease
CPSIGH_RS09010	COG0247	lactate metabolic process
CPSIGH_RS09015	COG1139	Iron-sulfur cluster binding protein
CPSIGH_RS09020	COG1556	Lactate utilization protein
CPSIGH_RS09050	COG1846	Transcriptional regulator
CPSIGH_RS09075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CPSIGH_RS09080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPSIGH_RS09110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CPSIGH_RS09130	COG2017	converts alpha-aldose to the beta-anomer
CPSIGH_RS09150	COG2272	Belongs to the type-B carboxylesterase lipase family
CPSIGH_RS09155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPSIGH_RS09165	COG1132	(ABC) transporter
CPSIGH_RS09170	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPSIGH_RS09170	COG0567	Dehydrogenase, E1 component
CPSIGH_RS09180	COG2239	Acts as a magnesium transporter
CPSIGH_RS09210	COG4122	O-methyltransferase activity
CPSIGH_RS09220	COG0297	glycogen (starch) synthase activity
CPSIGH_RS09225	COG3527	Alpha-acetolactate decarboxylase
CPSIGH_RS09250	COG0463	Glycosyl transferase, family 2
CPSIGH_RS09255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPSIGH_RS09260	COG1611	Belongs to the LOG family
CPSIGH_RS09265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPSIGH_RS09275	COG1113	amino acid transport
CPSIGH_RS09285	COG1113	amino acid transport
CPSIGH_RS09320	COG4166	transmembrane transport
CPSIGH_RS09325	COG1217	gtp-binding protein TYPA
CPSIGH_RS09355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPSIGH_RS09365	COG4166	transmembrane transport
CPSIGH_RS09375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPSIGH_RS09385	COG1122	ATPase activity
CPSIGH_RS09390	COG4721	ABC-type cobalt transport system, permease component
CPSIGH_RS09400	COG2354	Protein conserved in bacteria
CPSIGH_RS09405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPSIGH_RS09415	COG1132	(ABC) transporter
CPSIGH_RS09420	COG2824	Alkylphosphonate utilization operon protein PhnA
CPSIGH_RS09435	COG0012	GTP binding
CPSIGH_RS09470	COG1494	fructose-1,6-bisphosphatase
CPSIGH_RS09475	COG0114	fumarate hydratase activity
CPSIGH_RS09545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CPSIGH_RS09605	COG3956	TIGRFAM MazG family protein
CPSIGH_RS09610	COG0531	amino acid
CPSIGH_RS09620	COG1309	transcriptional regulator
CPSIGH_RS09630	COG2132	Multicopper oxidase
CPSIGH_RS09635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPSIGH_RS09640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPSIGH_RS09645	COG1523	belongs to the glycosyl hydrolase 13 family
CPSIGH_RS09665	COG2070	2-Nitropropane dioxygenase
CPSIGH_RS09670	COG0193	aminoacyl-tRNA hydrolase activity
CPSIGH_RS09680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPSIGH_RS09685	COG0596	Alpha beta hydrolase
CPSIGH_RS09725	COG2326	polyphosphate kinase activity
CPSIGH_RS09740	COG0488	(ABC) transporter
CPSIGH_RS09755	COG3583	domain protein
CPSIGH_RS09760	COG0084	hydrolase, TatD family'
CPSIGH_RS09775	COG3949	Membrane
CPSIGH_RS09780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CPSIGH_RS09790	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CPSIGH_RS09800	COG2259	Doxx family
CPSIGH_RS09820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CPSIGH_RS09845	COG0315	cyclic pyranopterin monophosphate synthase activity
CPSIGH_RS09845	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPSIGH_RS09850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPSIGH_RS09855	COG2205	protein histidine kinase activity
CPSIGH_RS09860	COG0745	RESPONSE REGULATOR receiver
CPSIGH_RS09870	COG0254	rRNA binding
CPSIGH_RS09900	COG1309	transcriptional regulator
CPSIGH_RS09910	COG0765	amino acid transport
CPSIGH_RS09915	COG0765	amino acid transport
CPSIGH_RS09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPSIGH_RS09925	COG1126	abc transporter atp-binding protein
CPSIGH_RS09975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPSIGH_RS09985	COG1201	RNA secondary structure unwinding
CPSIGH_RS09990	COG1218	3'(2'),5'-bisphosphate nucleotidase
CPSIGH_RS10005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CPSIGH_RS10030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPSIGH_RS10045	COG4166	transmembrane transport
CPSIGH_RS10060	COG0019	diaminopimelate decarboxylase activity
CPSIGH_RS10065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPSIGH_RS10070	COG0534	Mate efflux family protein
CPSIGH_RS10085	COG3757	hydrolase, family 25
CPSIGH_RS10095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPSIGH_RS10105	COG1024	Enoyl-CoA hydratase
CPSIGH_RS10110	COG0656	L-ascorbic acid biosynthetic process
CPSIGH_RS10125	COG0545	Peptidyl-prolyl cis-trans isomerase
CPSIGH_RS10130	COG0372	Belongs to the citrate synthase family
CPSIGH_RS10150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPSIGH_RS10155	COG2252	PERMEase
CPSIGH_RS10180	COG1652	LysM domain
CPSIGH_RS10190	COG1061	Type III restriction enzyme res subunit
CPSIGH_RS10230	COG1131	(ABC) transporter
CPSIGH_RS10245	COG1842	Phage shock protein A
CPSIGH_RS10250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPSIGH_RS10265	COG0477	Major facilitator Superfamily
CPSIGH_RS10270	COG0305	Participates in initiation and elongation during chromosome replication
CPSIGH_RS10275	COG3387	PFAM Glycoside hydrolase 15-related
CPSIGH_RS10290	COG0629	single-stranded DNA binding
CPSIGH_RS10315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPSIGH_RS10335	COG0300	oxidoreductase activity
CPSIGH_RS10350	COG0586	Pfam SNARE associated Golgi protein
CPSIGH_RS10355	COG0783	Belongs to the Dps family
CPSIGH_RS10360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPSIGH_RS10365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CPSIGH_RS10365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPSIGH_RS10375	COG1511	domain protein
CPSIGH_RS10385	COG0577	efflux transmembrane transporter activity
CPSIGH_RS10385	COG1136	(ABC) transporter
CPSIGH_RS10405	COG4585	Histidine kinase
CPSIGH_RS10410	COG2197	response regulator
CPSIGH_RS10425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CPSIGH_RS10440	COG2186	Transcriptional regulator
CPSIGH_RS10445	COG0747	negative chemotaxis
CPSIGH_RS10450	COG0601	transmembrane transport
CPSIGH_RS10455	COG0444	Belongs to the ABC transporter superfamily
CPSIGH_RS10460	COG4608	Belongs to the ABC transporter superfamily
CPSIGH_RS10465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPSIGH_RS10505	COG3422	double-strand break repair
CPSIGH_RS10520	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CPSIGH_RS10540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CPSIGH_RS10545	COG0512	Glutamine amidotransferase of anthranilate synthase
CPSIGH_RS10555	COG0134	indole-3-glycerol-phosphate synthase activity
CPSIGH_RS10555	COG0135	phosphoribosylanthranilate isomerase activity
CPSIGH_RS10585	COG1687	branched-chain amino acid
CPSIGH_RS10590	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CPSIGH_RS10595	COG1678	Uncharacterized ACR, COG1678
CPSIGH_RS10600	COG0617	tRNA 3'-terminal CCA addition
CPSIGH_RS10635	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPSIGH_RS10635	COG3409	Peptidoglycan-binding domain 1 protein
CPSIGH_RS10650	COG1192	Involved in chromosome partitioning
CPSIGH_RS10665	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPSIGH_RS10675	COG0230	Belongs to the bacterial ribosomal protein bL34 family