locus-tag	class	description
cpvd57_RS00010	COG0592	DNA-directed DNA polymerase activity
cpvd57_RS00025	COG0187	DNA topoisomerase II activity
cpvd57_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
cpvd57_RS00135	COG1120	ATPase activity
cpvd57_RS00140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS00145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS00150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
cpvd57_RS00160	COG2815	serine threonine protein kinase
cpvd57_RS00160	COG0515	serine threonine protein kinase
cpvd57_RS00165	COG0515	serine threonine protein kinase
cpvd57_RS00170	COG0768	penicillin binding
cpvd57_RS00190	COG1716	ATPase activity
cpvd57_RS00190	COG1716	ATPase activity
cpvd57_RS00220	COG1120	ATPase activity
cpvd57_RS00225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS00230	COG2239	Acts as a magnesium transporter
cpvd57_RS00235	COG0366	Alpha amylase catalytic
cpvd57_RS00290	COG0517	IMP dehydrogenase activity
cpvd57_RS00290	COG1125	glycine betaine transport
cpvd57_RS00295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
cpvd57_RS00315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
cpvd57_RS00325	COG3757	hydrolase, family 25
cpvd57_RS00325	COG3409	Peptidoglycan-binding domain 1 protein
cpvd57_RS00350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
cpvd57_RS00375	COG1846	Transcriptional regulator
cpvd57_RS00390	COG3180	Ammonia monooxygenase
cpvd57_RS00400	COG0730	response to heat
cpvd57_RS00415	COG1643	Atp-dependent helicase
cpvd57_RS00425	COG0519	Catalyzes the synthesis of GMP from XMP
cpvd57_RS00435	COG0393	Putative heavy-metal-binding
cpvd57_RS00440	COG2501	S4 domain
cpvd57_RS00465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
cpvd57_RS00470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
cpvd57_RS00480	COG3590	peptidase
cpvd57_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
cpvd57_RS00515	COG0277	FAD linked oxidase domain protein
cpvd57_RS00545	COG1216	Glycosyl transferase, family 2
cpvd57_RS00550	COG0803	Belongs to the bacterial solute-binding protein 9 family
cpvd57_RS00555	COG1121	(ABC) transporter
cpvd57_RS00560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
cpvd57_RS00565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
cpvd57_RS00570	COG0803	Belongs to the bacterial solute-binding protein 9 family
cpvd57_RS00595	COG0604	alcohol dehydrogenase
cpvd57_RS00620	COG0471	metal ion transport
cpvd57_RS00630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
cpvd57_RS00630	COG1263	PTS System
cpvd57_RS00635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
cpvd57_RS00635	COG1263	PTS System
cpvd57_RS00635	COG2190	(PTS) system
cpvd57_RS00660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
cpvd57_RS00675	COG0287	Prephenate dehydrogenase
cpvd57_RS00695	COG2409	Drug exporters of the RND superfamily
cpvd57_RS00700	COG0343	queuine tRNA-ribosyltransferase activity
cpvd57_RS00710	COG2610	gluconate transmembrane transporter activity
cpvd57_RS00715	COG3265	gluconokinase activity
cpvd57_RS00720	COG1063	alcohol dehydrogenase
cpvd57_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
cpvd57_RS00735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
cpvd57_RS00760	COG2610	gluconate transmembrane transporter activity
cpvd57_RS00765	COG2084	Dehydrogenase
cpvd57_RS00780	COG0179	Fumarylacetoacetate (FAA) hydrolase
cpvd57_RS00785	COG3442	glutamine amidotransferase
cpvd57_RS00790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
cpvd57_RS00805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
cpvd57_RS00810	COG2390	Transcriptional regulator
cpvd57_RS00815	COG0813	purine-nucleoside phosphorylase activity
cpvd57_RS00830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
cpvd57_RS00860	COG0697	spore germination
cpvd57_RS00865	COG0527	aspartate kinase activity
cpvd57_RS00925	COG1840	ABC-type Fe3 transport system, periplasmic component
cpvd57_RS00930	COG2271	Major facilitator Superfamily
cpvd57_RS00940	COG3852	Histidine kinase
cpvd57_RS00960	COG0651	ATP synthesis coupled electron transport
cpvd57_RS00970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
cpvd57_RS00970	COG2111	Na H antiporter
cpvd57_RS00990	COG4152	abc transporter atp-binding protein
cpvd57_RS01045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
cpvd57_RS01065	COG0494	nUDIX hydrolase
cpvd57_RS01130	COG1111	helicase
cpvd57_RS01130	COG1205	dead DEAH box helicase
cpvd57_RS01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
cpvd57_RS01140	COG1754	DNA topoisomerase type I activity
cpvd57_RS01145	COG1297	OPT oligopeptide transporter protein
cpvd57_RS01155	COG0470	DNA polymerase III
cpvd57_RS01170	COG0318	PFAM AMP-dependent synthetase and ligase
cpvd57_RS01180	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
cpvd57_RS01190	COG1088	dTDP-glucose 4,6-dehydratase activity
cpvd57_RS01200	COG1505	serine-type exopeptidase activity
cpvd57_RS01210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
cpvd57_RS01215	COG1396	sequence-specific DNA binding
cpvd57_RS01215	COG3800	Transcriptional regulator
cpvd57_RS01225	COG1053	succinate dehydrogenase
cpvd57_RS01230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
cpvd57_RS01240	COG2733	membrane
cpvd57_RS01250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
cpvd57_RS01270	COG1882	Formate acetyltransferase
cpvd57_RS01290	COG0318	PFAM AMP-dependent synthetase and ligase
cpvd57_RS01305	COG5002	protein histidine kinase activity
cpvd57_RS01310	COG0745	RESPONSE REGULATOR receiver
cpvd57_RS01330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
cpvd57_RS01340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
cpvd57_RS01340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
cpvd57_RS01370	COG1648	precorrin-2 dehydrogenase activity
cpvd57_RS01370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
cpvd57_RS01385	COG2217	Heavy metal translocating P-type atpase
cpvd57_RS01395	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
cpvd57_RS01410	COG0406	alpha-ribazole phosphatase activity
cpvd57_RS01420	COG0785	Cytochrome C biogenesis protein
cpvd57_RS01430	COG0275	rRNA processing
cpvd57_RS01445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS01450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
cpvd57_RS01480	COG3069	C4-dicarboxylate transmembrane transporter activity
cpvd57_RS01485	COG4948	Mandelate Racemase Muconate Lactonizing
cpvd57_RS01500	COG0438	transferase activity, transferring glycosyl groups
cpvd57_RS01500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
cpvd57_RS01510	COG0039	L-malate dehydrogenase activity
cpvd57_RS01515	COG0644	oxidoreductase
cpvd57_RS01520	COG0142	geranyltranstransferase activity
cpvd57_RS01545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
cpvd57_RS01570	COG3579	cysteine-type endopeptidase activity
cpvd57_RS01575	COG1902	pentaerythritol trinitrate reductase activity
cpvd57_RS01595	COG0803	Belongs to the bacterial solute-binding protein 9 family
cpvd57_RS01605	COG1121	(ABC) transporter
cpvd57_RS01610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
cpvd57_RS01650	COG1131	(ABC) transporter
cpvd57_RS01665	COG0701	Predicted permease
cpvd57_RS01735	COG1302	Protein conserved in bacteria
cpvd57_RS01830	COG0814	amino acid
cpvd57_RS01835	COG1760	l-serine dehydratase
cpvd57_RS01840	COG0252	asparaginase activity
cpvd57_RS01890	COG1175	transmembrane transport
cpvd57_RS01895	COG3833	ABC-type maltose transport systems, permease component
cpvd57_RS01915	COG3842	ATPase activity
cpvd57_RS01920	COG0201	protein transport
cpvd57_RS01975	COG0203	ribosomal protein L17
cpvd57_RS01995	COG1404	Belongs to the peptidase S8 family
cpvd57_RS02005	COG1674	ftsk spoiiie
cpvd57_RS02060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
cpvd57_RS02130	COG0516	GMP reductase activity
cpvd57_RS02175	COG2011	ABC-type metal ion transport system permease component
cpvd57_RS02185	COG1464	Belongs to the NlpA lipoprotein family
cpvd57_RS02190	COG1464	Belongs to the NlpA lipoprotein family
cpvd57_RS02210	COG0803	Belongs to the bacterial solute-binding protein 9 family
cpvd57_RS02215	COG1121	(ABC) transporter
cpvd57_RS02225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
cpvd57_RS02225	COG1321	iron dependent repressor
cpvd57_RS02230	COG1321	iron dependent repressor
cpvd57_RS02235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
cpvd57_RS02240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
cpvd57_RS02275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS02280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
cpvd57_RS02295	COG2838	Isocitrate dehydrogenase
cpvd57_RS02300	COG2814	Major facilitator Superfamily
cpvd57_RS02305	COG0789	Transcriptional regulator
cpvd57_RS02305	COG4978	Transcriptional regulator
cpvd57_RS02320	COG0180	Tryptophanyl-tRNA synthetase
cpvd57_RS02325	COG1295	ribonuclease BN
cpvd57_RS02330	COG1686	Belongs to the peptidase S11 family
cpvd57_RS02365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
cpvd57_RS02370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
cpvd57_RS02370	COG1473	amidohydrolase
cpvd57_RS02385	COG2814	Major facilitator Superfamily
cpvd57_RS02395	COG4770	biotin carboxylase activity
cpvd57_RS02400	COG2897	thiosulfate sulfurtransferase activity
cpvd57_RS02410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
cpvd57_RS02410	COG2755	lipolytic protein G-D-S-L family
cpvd57_RS02420	COG0424	maF-like protein
cpvd57_RS02425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
cpvd57_RS02430	COG1609	Transcriptional regulator
cpvd57_RS02440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
cpvd57_RS02445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
cpvd57_RS02450	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
cpvd57_RS02450	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
cpvd57_RS02500	COG1316	TRANSCRIPTIONal
cpvd57_RS02510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
cpvd57_RS02540	COG1482	cell wall glycoprotein biosynthetic process
cpvd57_RS02565	COG0745	RESPONSE REGULATOR receiver
cpvd57_RS02570	COG5002	protein histidine kinase activity
cpvd57_RS02585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
cpvd57_RS02625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
cpvd57_RS02630	COG2135	peptidase activity
cpvd57_RS02635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
cpvd57_RS02670	COG0513	Belongs to the DEAD box helicase family
cpvd57_RS02695	COG0210	DNA helicase
cpvd57_RS02705	COG2816	NAD+ diphosphatase activity
cpvd57_RS02730	COG3480	Lon protease (S16) C-terminal proteolytic domain
cpvd57_RS02845	COG0483	inositol monophosphate 1-phosphatase activity
cpvd57_RS02850	COG0483	inositol monophosphate 1-phosphatase activity
cpvd57_RS02865	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
cpvd57_RS02870	COG2884	Cell division ATP-binding protein ftsE
cpvd57_RS02875	COG2177	Part of the ABC transporter FtsEX involved in
cpvd57_RS02885	COG0288	reversible hydration of carbon dioxide
cpvd57_RS02935	COG1061	Type III restriction enzyme res subunit
cpvd57_RS02950	COG1652	LysM domain
cpvd57_RS02975	COG2252	PERMEase
cpvd57_RS02980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
cpvd57_RS03000	COG0372	Belongs to the citrate synthase family
cpvd57_RS03005	COG0545	Peptidyl-prolyl cis-trans isomerase
cpvd57_RS03020	COG0656	L-ascorbic acid biosynthetic process
cpvd57_RS03025	COG1024	Enoyl-CoA hydratase
cpvd57_RS03035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
cpvd57_RS03045	COG3757	hydrolase, family 25
cpvd57_RS03060	COG0534	Mate efflux family protein
cpvd57_RS03065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
cpvd57_RS03070	COG0019	diaminopimelate decarboxylase activity
cpvd57_RS03085	COG4166	transmembrane transport
cpvd57_RS03100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
cpvd57_RS03120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
cpvd57_RS03135	COG1218	3'(2'),5'-bisphosphate nucleotidase
cpvd57_RS03140	COG1201	RNA secondary structure unwinding
cpvd57_RS03150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
cpvd57_RS03200	COG1126	abc transporter atp-binding protein
cpvd57_RS03205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
cpvd57_RS03210	COG0765	amino acid transport
cpvd57_RS03215	COG0765	amino acid transport
cpvd57_RS03225	COG1309	transcriptional regulator
cpvd57_RS03255	COG0254	rRNA binding
cpvd57_RS03265	COG0745	RESPONSE REGULATOR receiver
cpvd57_RS03270	COG2205	protein histidine kinase activity
cpvd57_RS03275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
cpvd57_RS03280	COG0521	Mo-molybdopterin cofactor biosynthetic process
cpvd57_RS03280	COG0315	cyclic pyranopterin monophosphate synthase activity
cpvd57_RS03305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
cpvd57_RS03325	COG2259	Doxx family
cpvd57_RS03335	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
cpvd57_RS03340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
cpvd57_RS03345	COG3949	Membrane
cpvd57_RS03360	COG0084	hydrolase, TatD family'
cpvd57_RS03365	COG3583	domain protein
cpvd57_RS03380	COG0488	(ABC) transporter
cpvd57_RS03395	COG2326	polyphosphate kinase activity
cpvd57_RS03430	COG0596	Alpha beta hydrolase
cpvd57_RS03435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
cpvd57_RS03445	COG0193	aminoacyl-tRNA hydrolase activity
cpvd57_RS03450	COG2070	2-Nitropropane dioxygenase
cpvd57_RS03470	COG1523	belongs to the glycosyl hydrolase 13 family
cpvd57_RS03475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
cpvd57_RS03480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
cpvd57_RS03485	COG2132	Multicopper oxidase
cpvd57_RS03500	COG1309	transcriptional regulator
cpvd57_RS03510	COG0531	amino acid
cpvd57_RS03515	COG3956	TIGRFAM MazG family protein
cpvd57_RS03575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
cpvd57_RS03645	COG0114	fumarate hydratase activity
cpvd57_RS03650	COG1494	fructose-1,6-bisphosphatase
cpvd57_RS03685	COG0012	GTP binding
cpvd57_RS03700	COG2824	Alkylphosphonate utilization operon protein PhnA
cpvd57_RS03705	COG1132	(ABC) transporter
cpvd57_RS03715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
cpvd57_RS03720	COG2354	Protein conserved in bacteria
cpvd57_RS03730	COG4721	ABC-type cobalt transport system, permease component
cpvd57_RS03735	COG1122	ATPase activity
cpvd57_RS03755	COG4166	transmembrane transport
cpvd57_RS03765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
cpvd57_RS03795	COG1217	gtp-binding protein TYPA
cpvd57_RS03800	COG4166	transmembrane transport
cpvd57_RS03835	COG1113	amino acid transport
cpvd57_RS03845	COG1113	amino acid transport
cpvd57_RS03855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
cpvd57_RS03860	COG1611	Belongs to the LOG family
cpvd57_RS03865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
cpvd57_RS03870	COG0463	Glycosyl transferase, family 2
cpvd57_RS03890	COG3527	Alpha-acetolactate decarboxylase
cpvd57_RS03895	COG0297	glycogen (starch) synthase activity
cpvd57_RS03905	COG4122	O-methyltransferase activity
cpvd57_RS03935	COG2239	Acts as a magnesium transporter
cpvd57_RS03945	COG0567	Dehydrogenase, E1 component
cpvd57_RS03945	COG0508	dehydrogenase complex catalyzes the overall conversion of
cpvd57_RS03950	COG1132	(ABC) transporter
cpvd57_RS03960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
cpvd57_RS03965	COG2272	Belongs to the type-B carboxylesterase lipase family
cpvd57_RS03980	COG2017	converts alpha-aldose to the beta-anomer
cpvd57_RS04000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
cpvd57_RS04030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
cpvd57_RS04035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
cpvd57_RS04060	COG1846	Transcriptional regulator
cpvd57_RS04075	COG1349	DNA-binding transcription factor activity
cpvd57_RS04090	COG1556	Lactate utilization protein
cpvd57_RS04095	COG1139	Iron-sulfur cluster binding protein
cpvd57_RS04100	COG0247	lactate metabolic process
cpvd57_RS04105	COG1620	l-lactate permease
cpvd57_RS04115	COG0019	diaminopimelate decarboxylase activity
cpvd57_RS04120	COG0460	homoserine dehydrogenase
cpvd57_RS04170	COG0356	it plays a direct role in the translocation of protons across the membrane
cpvd57_RS04175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
cpvd57_RS04180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
cpvd57_RS04220	COG0346	lactoylglutathione lyase activity
cpvd57_RS04245	COG1119	ATPase activity
cpvd57_RS04265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
cpvd57_RS04330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS04335	COG1120	ATPase activity
cpvd57_RS04345	COG0205	6-phosphofructokinase activity
cpvd57_RS04355	COG0667	Aldo Keto reductase
cpvd57_RS04365	COG0583	DNA-binding transcription factor activity
cpvd57_RS04390	COG0668	transmembrane transport
cpvd57_RS04430	COG0473	3-isopropylmalate dehydrogenase activity
cpvd57_RS04450	COG0179	Fumarylacetoacetate (FAA) hydrolase
cpvd57_RS04480	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
cpvd57_RS04515	COG0406	alpha-ribazole phosphatase activity
cpvd57_RS04515	COG0494	nUDIX hydrolase
cpvd57_RS04535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
cpvd57_RS04540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
cpvd57_RS04545	COG1461	Dihydroxyacetone kinase
cpvd57_RS04555	COG0511	ligase activity, forming carbon-carbon bonds
cpvd57_RS04560	COG0742	ribosomal rna small subunit methyltransferase
cpvd57_RS04590	COG0765	amino acid transport
cpvd57_RS04615	COG2226	methyltransferase
cpvd57_RS04620	COG0539	negative regulation of cytoplasmic translation
cpvd57_RS04630	COG0237	dephospho-CoA kinase activity
cpvd57_RS04650	COG3973	AAA domain
cpvd57_RS04660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
cpvd57_RS04675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
cpvd57_RS04690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
cpvd57_RS04705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
cpvd57_RS04720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
cpvd57_RS04740	COG0165	Argininosuccinate lyase
cpvd57_RS04745	COG2835	tetraacyldisaccharide 4'-kinase activity
cpvd57_RS04775	COG0647	UMP catabolic process
cpvd57_RS04805	COG0494	nUDIX hydrolase
cpvd57_RS04810	COG4974	Belongs to the 'phage' integrase family
cpvd57_RS04830	COG3104	oligopeptide transport
cpvd57_RS04835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
cpvd57_RS04845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
cpvd57_RS04860	COG1160	GTP binding
cpvd57_RS04865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
cpvd57_RS04870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
cpvd57_RS04875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
cpvd57_RS04880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
cpvd57_RS04885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
cpvd57_RS04890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS04895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS04900	COG1120	ATPase activity
cpvd57_RS04905	COG4264	IucA IucC family
cpvd57_RS04935	COG0653	protein targeting
cpvd57_RS04975	COG1253	flavin adenine dinucleotide binding
cpvd57_RS04980	COG0513	Belongs to the DEAD box helicase family
cpvd57_RS04985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
cpvd57_RS04995	COG0598	Magnesium transport protein CorA
cpvd57_RS05015	COG0477	Major facilitator Superfamily
cpvd57_RS05040	COG0463	Glycosyl transferase, family 2
cpvd57_RS05090	COG0300	oxidoreductase activity
cpvd57_RS05105	COG0805	protein transport
cpvd57_RS05115	COG2378	regulation of single-species biofilm formation
cpvd57_RS05135	COG4122	O-methyltransferase activity
cpvd57_RS05150	COG1362	aminopeptidase activity
cpvd57_RS05170	COG1027	Aspartate ammonia-lyase
cpvd57_RS05175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
cpvd57_RS05195	COG0646	methionine synthase
cpvd57_RS05195	COG1410	methionine synthase
cpvd57_RS05215	COG0667	Aldo Keto reductase
cpvd57_RS05225	COG0167	dihydroorotate dehydrogenase activity
cpvd57_RS05250	COG1461	Dihydroxyacetone kinase
cpvd57_RS05255	COG2376	Dihydroxyacetone kinase
cpvd57_RS05265	COG0488	(ABC) transporter
cpvd57_RS05330	COG0791	NLP P60 protein
cpvd57_RS05330	COG3883	PFAM NLP P60 protein
cpvd57_RS05360	COG2848	UPF0210 protein
cpvd57_RS05385	COG2151	metal-sulfur cluster biosynthetic enzyme
cpvd57_RS05390	COG0822	iron-sulfur transferase activity
cpvd57_RS05400	COG0396	ATPase activity
cpvd57_RS05445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
cpvd57_RS05450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
cpvd57_RS05470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
cpvd57_RS05490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
cpvd57_RS05500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
cpvd57_RS05510	COG0322	excinuclease ABC activity
cpvd57_RS05540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
cpvd57_RS05555	COG0242	peptide deformylase activity
cpvd57_RS05595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
cpvd57_RS05605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
cpvd57_RS05620	COG1090	epimerase
cpvd57_RS05645	COG0006	proline dipeptidase activity
cpvd57_RS05650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
cpvd57_RS05655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
cpvd57_RS05660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
cpvd57_RS05665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
cpvd57_RS05685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
cpvd57_RS05740	COG1760	l-serine dehydratase
cpvd57_RS05765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
cpvd57_RS05770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
cpvd57_RS05785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
cpvd57_RS05800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
cpvd57_RS05805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
cpvd57_RS05835	COG1946	Acyl-CoA thioesterase
cpvd57_RS05850	COG0156	8-amino-7-oxononanoate synthase activity
cpvd57_RS05865	COG1560	Kdo2-lipid A biosynthetic process
cpvd57_RS05870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
cpvd57_RS05885	COG2837	iron assimilation
cpvd57_RS05935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
cpvd57_RS05940	COG3253	May function as heme-dependent peroxidase
cpvd57_RS06025	COG2890	protein-(glutamine-N5) methyltransferase activity
cpvd57_RS06065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
cpvd57_RS06070	COG0450	alkyl hydroperoxide reductase
cpvd57_RS06085	COG1643	Atp-dependent helicase
cpvd57_RS06105	COG1349	DNA-binding transcription factor activity
cpvd57_RS06110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
cpvd57_RS06115	COG1349	DNA-binding transcription factor activity
cpvd57_RS06120	COG1105	Belongs to the carbohydrate kinase PfkB family
cpvd57_RS06125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
cpvd57_RS06125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
cpvd57_RS06125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
cpvd57_RS06130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
cpvd57_RS06135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
cpvd57_RS06145	COG2233	PERMEase
cpvd57_RS06150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
cpvd57_RS06165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
cpvd57_RS06180	COG1196	nuclear chromosome segregation
cpvd57_RS06200	COG2137	regulation of response to DNA damage stimulus
cpvd57_RS06205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
cpvd57_RS06215	COG1268	BioY protein
cpvd57_RS06220	COG1122	ATPase activity
cpvd57_RS06230	COG1842	Phage shock protein A
cpvd57_RS06235	COG1396	sequence-specific DNA binding
cpvd57_RS06260	COG1674	ftsk spoiiie
cpvd57_RS06270	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
cpvd57_RS06310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
cpvd57_RS06320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
cpvd57_RS06325	COG0534	Mate efflux family protein
cpvd57_RS06370	COG3022	response to hydroperoxide
cpvd57_RS06375	COG1648	precorrin-2 dehydrogenase activity
cpvd57_RS06375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
cpvd57_RS06380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
cpvd57_RS06385	COG0523	cobalamin synthesis protein
cpvd57_RS06390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
cpvd57_RS06390	COG2169	Transcriptional regulator
cpvd57_RS06455	COG0750	zinc metalloprotease
cpvd57_RS06510	COG4974	Belongs to the 'phage' integrase family
cpvd57_RS06535	COG0681	Belongs to the peptidase S26 family
cpvd57_RS06550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
cpvd57_RS06550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
cpvd57_RS06550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
cpvd57_RS06560	COG0336	Belongs to the RNA methyltransferase TrmD family
cpvd57_RS06565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
cpvd57_RS06585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
cpvd57_RS06615	COG1115	amino acid carrier protein
cpvd57_RS06620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
cpvd57_RS06645	COG0686	Belongs to the AlaDH PNT family
cpvd57_RS06650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
cpvd57_RS06655	COG1929	Belongs to the glycerate kinase type-1 family
cpvd57_RS06675	COG0058	SHG alpha-glucan phosphorylase activity
cpvd57_RS06685	COG0469	pyruvate kinase activity
cpvd57_RS06695	COG0134	indole-3-glycerol-phosphate synthase activity
cpvd57_RS06715	COG0483	inositol monophosphate 1-phosphatase activity
cpvd57_RS06780	COG2176	DNA-directed DNA polymerase activity
cpvd57_RS06805	COG1739	Uncharacterized protein family UPF0029
cpvd57_RS06810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
cpvd57_RS06835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
cpvd57_RS06850	COG0252	asparaginase activity
cpvd57_RS06870	COG3599	regulation of cell shape
cpvd57_RS06880	COG1799	cell septum assembly
cpvd57_RS06885	COG1496	oxidoreductase activity
cpvd57_RS06890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
cpvd57_RS06900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
cpvd57_RS06930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
cpvd57_RS06935	COG0768	penicillin binding
cpvd57_RS06975	COG0142	geranyltranstransferase activity
cpvd57_RS06990	COG0515	serine threonine protein kinase
cpvd57_RS06990	COG2815	serine threonine protein kinase
cpvd57_RS06995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
cpvd57_RS07015	COG1940	carbohydrate kinase activity
cpvd57_RS07020	COG0438	transferase activity, transferring glycosyl groups
cpvd57_RS07030	COG0791	NLP P60 protein
cpvd57_RS07080	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
cpvd57_RS07085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
cpvd57_RS07095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
cpvd57_RS07115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
cpvd57_RS07115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
cpvd57_RS07120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
cpvd57_RS07125	COG0509	glycine decarboxylation via glycine cleavage system
cpvd57_RS07155	COG0174	glutamine synthetase
cpvd57_RS07305	COG2056	Na+-H+ antiporter family
cpvd57_RS07315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
cpvd57_RS07340	COG0174	glutamine synthetase
cpvd57_RS07365	COG0557	exoribonuclease II activity
cpvd57_RS07380	COG3323	Protein of unknown function (DUF1653)
cpvd57_RS07380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
cpvd57_RS07420	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
cpvd57_RS07450	COG2860	membrane
cpvd57_RS07520	COG0423	glycine-tRNA ligase activity
cpvd57_RS07545	COG1381	Involved in DNA repair and RecF pathway recombination
cpvd57_RS07600	COG1022	Amp-dependent synthetase and ligase
cpvd57_RS07655	COG1114	Component of the transport system for branched-chain amino acids
cpvd57_RS07660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
cpvd57_RS07670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
cpvd57_RS07685	COG0747	negative chemotaxis
cpvd57_RS07690	COG0601	transmembrane transport
cpvd57_RS07695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
cpvd57_RS07700	COG4172	Belongs to the ABC transporter superfamily
cpvd57_RS07710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
cpvd57_RS07715	COG2391	methyltransferase activity
cpvd57_RS07720	COG0601	transmembrane transport
cpvd57_RS07740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
cpvd57_RS07745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
cpvd57_RS07770	COG1280	lysine exporter protein (LysE YggA)
cpvd57_RS07795	COG1307	EDD domain protein, DegV family
cpvd57_RS07800	COG0406	alpha-ribazole phosphatase activity
cpvd57_RS07810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
cpvd57_RS07825	COG2832	Protein of unknown function (DUF454)
cpvd57_RS07830	COG0569	domain protein
cpvd57_RS07830	COG2985	domain, Protein
cpvd57_RS07855	COG1530	ribonuclease E activity
cpvd57_RS07870	COG2423	ornithine cyclodeaminase activity
cpvd57_RS07880	COG0285	dihydrofolate synthase activity
cpvd57_RS07920	COG0544	peptidyl-prolyl cis-trans isomerase activity
cpvd57_RS07955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
cpvd57_RS07970	COG0668	transmembrane transport
cpvd57_RS08045	COG1131	(ABC) transporter
cpvd57_RS08050	COG3336	cytochrome c oxidase
cpvd57_RS08055	COG1966	Carbon starvation protein
cpvd57_RS08075	COG0604	alcohol dehydrogenase
cpvd57_RS08100	COG1376	ErfK ybiS ycfS ynhG family protein
cpvd57_RS08110	COG2130	NADP-dependent
cpvd57_RS08115	COG1335	isochorismatase
cpvd57_RS08160	COG2197	response regulator
cpvd57_RS08210	COG1234	tRNA 3'-trailer cleavage
cpvd57_RS08235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
cpvd57_RS08280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
cpvd57_RS08290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
cpvd57_RS08310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
cpvd57_RS08375	COG0033	Phosphoglucomutase
cpvd57_RS08390	COG1136	(ABC) transporter
cpvd57_RS08390	COG0577	efflux transmembrane transporter activity
cpvd57_RS08395	COG1136	(ABC) transporter
cpvd57_RS08395	COG0577	efflux transmembrane transporter activity
cpvd57_RS08425	COG2197	response regulator
cpvd57_RS08435	COG1045	serine acetyltransferase
cpvd57_RS08475	COG1271	oxidase subunit
cpvd57_RS08480	COG1294	oxidase, subunit
cpvd57_RS08485	COG4988	ABC transporter
cpvd57_RS08490	COG1132	(ABC) transporter
cpvd57_RS08515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
cpvd57_RS08545	COG1597	lipid kinase activity
cpvd57_RS08560	COG0354	folic acid binding
cpvd57_RS08585	COG1780	Probably involved in ribonucleotide reductase function
cpvd57_RS08590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
cpvd57_RS08600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
cpvd57_RS08605	COG0047	phosphoribosylformylglycinamidine synthase activity
cpvd57_RS08610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
cpvd57_RS08615	COG0386	Belongs to the glutathione peroxidase family
cpvd57_RS08635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
cpvd57_RS08640	COG0569	domain protein
cpvd57_RS08645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
cpvd57_RS08650	COG0151	Belongs to the GarS family
cpvd57_RS08655	COG0537	adenosine 5'-monophosphoramidase activity
cpvd57_RS08665	COG2205	protein histidine kinase activity
cpvd57_RS08670	COG0745	RESPONSE REGULATOR receiver
cpvd57_RS08700	COG0028	Belongs to the TPP enzyme family
cpvd57_RS08740	COG1609	Transcriptional regulator
cpvd57_RS08750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
cpvd57_RS08770	COG1329	Transcriptional regulator
cpvd57_RS08775	COG2847	Copper chaperone PCu(A)C
cpvd57_RS08790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
cpvd57_RS08800	COG0288	reversible hydration of carbon dioxide
cpvd57_RS08815	COG0542	response to heat
cpvd57_RS08825	COG0477	Major facilitator Superfamily
cpvd57_RS08830	COG1957	nucleoside hydrolase
cpvd57_RS08845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
cpvd57_RS08860	COG1301	dicarboxylic acid transport
cpvd57_RS08865	COG1012	belongs to the aldehyde dehydrogenase family
cpvd57_RS08870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
cpvd57_RS08875	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
cpvd57_RS08880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
cpvd57_RS08910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
cpvd57_RS08915	COG0302	gtp cyclohydrolase
cpvd57_RS08920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
cpvd57_RS08925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
cpvd57_RS08935	COG2027	D-alanyl-D-alanine carboxypeptidase
cpvd57_RS08940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
cpvd57_RS08945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
cpvd57_RS08945	COG0425	Belongs to the sulfur carrier protein TusA family
cpvd57_RS08950	COG1301	dicarboxylic acid transport
cpvd57_RS08965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
cpvd57_RS08970	COG2326	polyphosphate kinase activity
cpvd57_RS09010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
cpvd57_RS09010	COG2111	Na H antiporter
cpvd57_RS09015	COG1006	Multisubunit Na H antiporter MnhC subunit
cpvd57_RS09020	COG0651	ATP synthesis coupled electron transport
cpvd57_RS09040	COG1051	belongs to the nudix hydrolase family
cpvd57_RS09060	COG0242	peptide deformylase activity
cpvd57_RS09065	COG0456	acetyltransferase
cpvd57_RS09075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
cpvd57_RS09100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
cpvd57_RS09115	COG0280	phosphate acetyltransferase
cpvd57_RS09135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
cpvd57_RS09140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
cpvd57_RS09170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
cpvd57_RS09175	COG1333	cytochrome c biogenesis protein
cpvd57_RS09185	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
cpvd57_RS09190	COG3005	denitrification pathway
cpvd57_RS09205	COG4129	membrane
cpvd57_RS09250	COG0191	fructose-bisphosphate aldolase activity
cpvd57_RS09265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
cpvd57_RS09280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
cpvd57_RS09320	COG1131	(ABC) transporter
cpvd57_RS09350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
cpvd57_RS09370	COG0577	efflux transmembrane transporter activity
cpvd57_RS09370	COG1136	(ABC) transporter
cpvd57_RS09375	COG1136	(ABC) transporter
cpvd57_RS09380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
cpvd57_RS09420	COG0789	Transcriptional regulator
cpvd57_RS09435	COG0443	Heat shock 70 kDa protein
cpvd57_RS09470	COG0601	transmembrane transport
cpvd57_RS09490	COG2181	nitrate reductase activity
cpvd57_RS09490	COG0247	lactate metabolic process
cpvd57_RS09505	COG1120	ATPase activity
cpvd57_RS09510	COG4139	cobalamin transport
cpvd57_RS09520	COG0829	nickel cation binding
cpvd57_RS09525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
cpvd57_RS09530	COG0830	nickel cation binding
cpvd57_RS09535	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
cpvd57_RS09540	COG0804	urea catabolic process
cpvd57_RS09545	COG0832	Belongs to the urease beta subunit family
cpvd57_RS09550	COG0831	urea catabolic process
cpvd57_RS09570	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
cpvd57_RS09570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
cpvd57_RS09590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
cpvd57_RS09605	COG1012	belongs to the aldehyde dehydrogenase family
cpvd57_RS09615	COG1472	Belongs to the glycosyl hydrolase 3 family
cpvd57_RS09625	COG4981	capsule polysaccharide biosynthetic process
cpvd57_RS09630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
cpvd57_RS09630	COG2755	lipolytic protein G-D-S-L family
cpvd57_RS09640	COG0438	transferase activity, transferring glycosyl groups
cpvd57_RS09645	COG0500	methyltransferase
cpvd57_RS09690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
cpvd57_RS09695	COG3321	synthase
cpvd57_RS09695	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
cpvd57_RS09695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
cpvd57_RS09700	COG0318	PFAM AMP-dependent synthetase and ligase
cpvd57_RS09705	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
cpvd57_RS09715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
cpvd57_RS09715	COG5479	isomerase activity
cpvd57_RS09730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
cpvd57_RS09735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
cpvd57_RS09740	COG0671	phosphoesterase, PA-phosphatase related
cpvd57_RS09745	COG1216	Glycosyl transferase, family 2
cpvd57_RS09755	COG0671	phosphoesterase, PA-phosphatase related
cpvd57_RS09765	COG0584	glycerophosphoryl diester phosphodiesterase
cpvd57_RS09770	COG2271	Major facilitator Superfamily
cpvd57_RS09785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
cpvd57_RS09790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
cpvd57_RS09800	COG0561	phosphatase activity
cpvd57_RS09815	COG2188	Transcriptional regulator
cpvd57_RS09835	COG0077	Prephenate dehydratase
cpvd57_RS09840	COG0154	amidase activity
cpvd57_RS09850	COG1316	TRANSCRIPTIONal
cpvd57_RS09880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
cpvd57_RS09910	COG0431	NADPH-dependent FMN reductase
cpvd57_RS09915	COG2814	Major facilitator Superfamily
cpvd57_RS09925	COG2271	Major facilitator Superfamily
cpvd57_RS09940	COG5650	phosphatidylinositol metabolic process
cpvd57_RS09960	COG2197	response regulator
cpvd57_RS09980	COG3764	Sortase (surface protein transpeptidase)
cpvd57_RS09985	COG0706	membrane insertase activity
cpvd57_RS10010	COG0564	pseudouridine synthase activity
cpvd57_RS10035	COG1131	(ABC) transporter
cpvd57_RS10050	COG1842	Phage shock protein A
cpvd57_RS10055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
cpvd57_RS10070	COG0477	Major facilitator Superfamily
cpvd57_RS10075	COG0305	Participates in initiation and elongation during chromosome replication
cpvd57_RS10080	COG3387	PFAM Glycoside hydrolase 15-related
cpvd57_RS10090	COG0629	single-stranded DNA binding
cpvd57_RS10110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
cpvd57_RS10130	COG0300	oxidoreductase activity
cpvd57_RS10145	COG0586	Pfam SNARE associated Golgi protein
cpvd57_RS10150	COG0783	Belongs to the Dps family
cpvd57_RS10155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
cpvd57_RS10160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
cpvd57_RS10160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
cpvd57_RS10170	COG1511	domain protein
cpvd57_RS10180	COG1136	(ABC) transporter
cpvd57_RS10180	COG0577	efflux transmembrane transporter activity
cpvd57_RS10200	COG4585	Histidine kinase
cpvd57_RS10205	COG2197	response regulator
cpvd57_RS10220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
cpvd57_RS10235	COG2186	Transcriptional regulator
cpvd57_RS10240	COG0747	negative chemotaxis
cpvd57_RS10245	COG0601	transmembrane transport
cpvd57_RS10250	COG0444	Belongs to the ABC transporter superfamily
cpvd57_RS10255	COG4608	Belongs to the ABC transporter superfamily
cpvd57_RS10260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
cpvd57_RS10300	COG3422	double-strand break repair
cpvd57_RS10315	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
cpvd57_RS10335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
cpvd57_RS10340	COG0512	Glutamine amidotransferase of anthranilate synthase
cpvd57_RS10350	COG0135	phosphoribosylanthranilate isomerase activity
cpvd57_RS10350	COG0134	indole-3-glycerol-phosphate synthase activity
cpvd57_RS10385	COG1687	branched-chain amino acid
cpvd57_RS10390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
cpvd57_RS10395	COG1678	Uncharacterized ACR, COG1678
cpvd57_RS10400	COG0617	tRNA 3'-terminal CCA addition
cpvd57_RS10435	COG3409	Peptidoglycan-binding domain 1 protein
cpvd57_RS10435	COG0860	N-Acetylmuramoyl-L-alanine amidase
cpvd57_RS10450	COG1192	Involved in chromosome partitioning
cpvd57_RS10465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
cpvd57_RS10475	COG0230	Belongs to the bacterial ribosomal protein bL34 family