locus-tag	class	description
CpsigB_RS00015	COG0592	DNA-directed DNA polymerase activity
CpsigB_RS00030	COG0187	DNA topoisomerase II activity
CpsigB_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CpsigB_RS00140	COG1120	ATPase activity
CpsigB_RS00145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS00150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS00155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpsigB_RS00165	COG0515	serine threonine protein kinase
CpsigB_RS00165	COG2815	serine threonine protein kinase
CpsigB_RS00170	COG0515	serine threonine protein kinase
CpsigB_RS00175	COG0768	penicillin binding
CpsigB_RS00195	COG1716	ATPase activity
CpsigB_RS00195	COG1716	ATPase activity
CpsigB_RS00225	COG1120	ATPase activity
CpsigB_RS00230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS00235	COG2239	Acts as a magnesium transporter
CpsigB_RS00240	COG0366	Alpha amylase catalytic
CpsigB_RS00295	COG1125	glycine betaine transport
CpsigB_RS00295	COG0517	IMP dehydrogenase activity
CpsigB_RS00305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpsigB_RS00325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CpsigB_RS00335	COG3757	hydrolase, family 25
CpsigB_RS00335	COG3409	Peptidoglycan-binding domain 1 protein
CpsigB_RS00360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CpsigB_RS00385	COG1846	Transcriptional regulator
CpsigB_RS00400	COG3180	Ammonia monooxygenase
CpsigB_RS00410	COG0730	response to heat
CpsigB_RS00425	COG1643	Atp-dependent helicase
CpsigB_RS00435	COG0519	Catalyzes the synthesis of GMP from XMP
CpsigB_RS00445	COG0393	Putative heavy-metal-binding
CpsigB_RS00450	COG2501	S4 domain
CpsigB_RS00475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CpsigB_RS00480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CpsigB_RS00490	COG3590	peptidase
CpsigB_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
CpsigB_RS00525	COG0277	FAD linked oxidase domain protein
CpsigB_RS00555	COG1216	Glycosyl transferase, family 2
CpsigB_RS00565	COG1121	(ABC) transporter
CpsigB_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpsigB_RS00575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpsigB_RS00580	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpsigB_RS00605	COG0604	alcohol dehydrogenase
CpsigB_RS00630	COG0471	metal ion transport
CpsigB_RS00640	COG1263	PTS System
CpsigB_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpsigB_RS00645	COG2190	(PTS) system
CpsigB_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpsigB_RS00645	COG1263	PTS System
CpsigB_RS00670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpsigB_RS00685	COG0287	Prephenate dehydrogenase
CpsigB_RS00705	COG2409	Drug exporters of the RND superfamily
CpsigB_RS00710	COG0343	queuine tRNA-ribosyltransferase activity
CpsigB_RS00720	COG2610	gluconate transmembrane transporter activity
CpsigB_RS00725	COG3265	gluconokinase activity
CpsigB_RS00730	COG1063	alcohol dehydrogenase
CpsigB_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
CpsigB_RS00750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpsigB_RS00775	COG2610	gluconate transmembrane transporter activity
CpsigB_RS00780	COG2084	Dehydrogenase
CpsigB_RS00795	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpsigB_RS00805	COG3442	glutamine amidotransferase
CpsigB_RS00810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CpsigB_RS00825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CpsigB_RS00830	COG2390	Transcriptional regulator
CpsigB_RS00835	COG0813	purine-nucleoside phosphorylase activity
CpsigB_RS00850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpsigB_RS00875	COG0697	spore germination
CpsigB_RS00880	COG0527	aspartate kinase activity
CpsigB_RS00940	COG1840	ABC-type Fe3 transport system, periplasmic component
CpsigB_RS00945	COG2271	Major facilitator Superfamily
CpsigB_RS00955	COG3852	Histidine kinase
CpsigB_RS00975	COG0651	ATP synthesis coupled electron transport
CpsigB_RS00985	COG2111	Na H antiporter
CpsigB_RS00985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpsigB_RS01005	COG4152	abc transporter atp-binding protein
CpsigB_RS01035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpsigB_RS01060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CpsigB_RS01080	COG0494	nUDIX hydrolase
CpsigB_RS01150	COG1111	helicase
CpsigB_RS01150	COG1205	dead DEAH box helicase
CpsigB_RS01160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CpsigB_RS01160	COG1754	DNA topoisomerase type I activity
CpsigB_RS01165	COG1297	OPT oligopeptide transporter protein
CpsigB_RS01175	COG0470	DNA polymerase III
CpsigB_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
CpsigB_RS01200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CpsigB_RS01210	COG1088	dTDP-glucose 4,6-dehydratase activity
CpsigB_RS01220	COG1505	serine-type exopeptidase activity
CpsigB_RS01235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CpsigB_RS01240	COG1396	sequence-specific DNA binding
CpsigB_RS01240	COG3800	Transcriptional regulator
CpsigB_RS01250	COG1053	succinate dehydrogenase
CpsigB_RS01255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CpsigB_RS01265	COG2733	membrane
CpsigB_RS01275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CpsigB_RS01295	COG1882	Formate acetyltransferase
CpsigB_RS01315	COG0318	PFAM AMP-dependent synthetase and ligase
CpsigB_RS01330	COG5002	protein histidine kinase activity
CpsigB_RS01335	COG0745	RESPONSE REGULATOR receiver
CpsigB_RS01355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CpsigB_RS01375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CpsigB_RS01375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CpsigB_RS01405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpsigB_RS01405	COG1648	precorrin-2 dehydrogenase activity
CpsigB_RS01420	COG2217	Heavy metal translocating P-type atpase
CpsigB_RS01430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CpsigB_RS01445	COG0406	alpha-ribazole phosphatase activity
CpsigB_RS01455	COG0785	Cytochrome C biogenesis protein
CpsigB_RS01465	COG0275	rRNA processing
CpsigB_RS01480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS01485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpsigB_RS01515	COG3069	C4-dicarboxylate transmembrane transporter activity
CpsigB_RS01520	COG4948	Mandelate Racemase Muconate Lactonizing
CpsigB_RS01535	COG0438	transferase activity, transferring glycosyl groups
CpsigB_RS01535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CpsigB_RS01545	COG0039	L-malate dehydrogenase activity
CpsigB_RS01550	COG0644	oxidoreductase
CpsigB_RS01555	COG0142	geranyltranstransferase activity
CpsigB_RS01580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpsigB_RS01605	COG3579	cysteine-type endopeptidase activity
CpsigB_RS01610	COG1902	pentaerythritol trinitrate reductase activity
CpsigB_RS01630	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpsigB_RS01640	COG1121	(ABC) transporter
CpsigB_RS01645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpsigB_RS01675	COG2197	response regulator
CpsigB_RS01685	COG1131	(ABC) transporter
CpsigB_RS01700	COG0701	Predicted permease
CpsigB_RS01770	COG1302	Protein conserved in bacteria
CpsigB_RS01865	COG0814	amino acid
CpsigB_RS01870	COG1760	l-serine dehydratase
CpsigB_RS01875	COG0252	asparaginase activity
CpsigB_RS01925	COG1175	transmembrane transport
CpsigB_RS01930	COG3833	ABC-type maltose transport systems, permease component
CpsigB_RS01950	COG3842	ATPase activity
CpsigB_RS01955	COG0201	protein transport
CpsigB_RS02005	COG0203	ribosomal protein L17
CpsigB_RS02025	COG1404	Belongs to the peptidase S8 family
CpsigB_RS02035	COG1674	ftsk spoiiie
CpsigB_RS02090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CpsigB_RS02160	COG0516	GMP reductase activity
CpsigB_RS02205	COG2011	ABC-type metal ion transport system permease component
CpsigB_RS02215	COG1464	Belongs to the NlpA lipoprotein family
CpsigB_RS02220	COG1464	Belongs to the NlpA lipoprotein family
CpsigB_RS02235	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpsigB_RS02240	COG1121	(ABC) transporter
CpsigB_RS02250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpsigB_RS02250	COG1321	iron dependent repressor
CpsigB_RS02255	COG1321	iron dependent repressor
CpsigB_RS02260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CpsigB_RS02265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CpsigB_RS02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS02305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CpsigB_RS02320	COG2838	Isocitrate dehydrogenase
CpsigB_RS02325	COG2814	Major facilitator Superfamily
CpsigB_RS02330	COG0789	Transcriptional regulator
CpsigB_RS02330	COG4978	Transcriptional regulator
CpsigB_RS02345	COG0180	Tryptophanyl-tRNA synthetase
CpsigB_RS02350	COG1295	ribonuclease BN
CpsigB_RS02355	COG1686	Belongs to the peptidase S11 family
CpsigB_RS02390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpsigB_RS02395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CpsigB_RS02395	COG1473	amidohydrolase
CpsigB_RS02410	COG2814	Major facilitator Superfamily
CpsigB_RS02420	COG4770	biotin carboxylase activity
CpsigB_RS02425	COG2897	thiosulfate sulfurtransferase activity
CpsigB_RS02435	COG2755	lipolytic protein G-D-S-L family
CpsigB_RS02435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpsigB_RS02445	COG0424	maF-like protein
CpsigB_RS02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CpsigB_RS02455	COG1609	Transcriptional regulator
CpsigB_RS02465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpsigB_RS02470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpsigB_RS02475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CpsigB_RS02475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CpsigB_RS02525	COG1316	TRANSCRIPTIONal
CpsigB_RS02535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CpsigB_RS02570	COG1482	cell wall glycoprotein biosynthetic process
CpsigB_RS02595	COG0745	RESPONSE REGULATOR receiver
CpsigB_RS02600	COG5002	protein histidine kinase activity
CpsigB_RS02615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CpsigB_RS02655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CpsigB_RS02660	COG2135	peptidase activity
CpsigB_RS02665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CpsigB_RS02700	COG0513	Belongs to the DEAD box helicase family
CpsigB_RS02725	COG0210	DNA helicase
CpsigB_RS02735	COG2816	NAD+ diphosphatase activity
CpsigB_RS02760	COG3480	Lon protease (S16) C-terminal proteolytic domain
CpsigB_RS02885	COG0483	inositol monophosphate 1-phosphatase activity
CpsigB_RS02890	COG0483	inositol monophosphate 1-phosphatase activity
CpsigB_RS02905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CpsigB_RS02915	COG2884	Cell division ATP-binding protein ftsE
CpsigB_RS02920	COG2177	Part of the ABC transporter FtsEX involved in
CpsigB_RS02935	COG0288	reversible hydration of carbon dioxide
CpsigB_RS02980	COG0564	pseudouridine synthase activity
CpsigB_RS03005	COG0706	membrane insertase activity
CpsigB_RS03010	COG3764	Sortase (surface protein transpeptidase)
CpsigB_RS03025	COG2197	response regulator
CpsigB_RS03045	COG5650	phosphatidylinositol metabolic process
CpsigB_RS03055	COG2271	Major facilitator Superfamily
CpsigB_RS03065	COG2814	Major facilitator Superfamily
CpsigB_RS03070	COG0431	NADPH-dependent FMN reductase
CpsigB_RS03100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CpsigB_RS03130	COG1316	TRANSCRIPTIONal
CpsigB_RS03140	COG0154	amidase activity
CpsigB_RS03165	COG2188	Transcriptional regulator
CpsigB_RS03180	COG0561	phosphatase activity
CpsigB_RS03190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpsigB_RS03195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS03210	COG2271	Major facilitator Superfamily
CpsigB_RS03215	COG0584	glycerophosphoryl diester phosphodiesterase
CpsigB_RS03225	COG0671	phosphoesterase, PA-phosphatase related
CpsigB_RS03235	COG1216	Glycosyl transferase, family 2
CpsigB_RS03240	COG0671	phosphoesterase, PA-phosphatase related
CpsigB_RS03245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CpsigB_RS03250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CpsigB_RS03265	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpsigB_RS03265	COG5479	isomerase activity
CpsigB_RS03275	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CpsigB_RS03280	COG0318	PFAM AMP-dependent synthetase and ligase
CpsigB_RS03285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CpsigB_RS03285	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CpsigB_RS03285	COG3321	synthase
CpsigB_RS03290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpsigB_RS03335	COG0500	methyltransferase
CpsigB_RS03340	COG0438	transferase activity, transferring glycosyl groups
CpsigB_RS03355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpsigB_RS03355	COG2755	lipolytic protein G-D-S-L family
CpsigB_RS03360	COG4981	capsule polysaccharide biosynthetic process
CpsigB_RS03370	COG1472	Belongs to the glycosyl hydrolase 3 family
CpsigB_RS03380	COG1012	belongs to the aldehyde dehydrogenase family
CpsigB_RS03395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CpsigB_RS03415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpsigB_RS03415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpsigB_RS03440	COG0831	urea catabolic process
CpsigB_RS03445	COG0832	Belongs to the urease beta subunit family
CpsigB_RS03450	COG0804	urea catabolic process
CpsigB_RS03455	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CpsigB_RS03460	COG0830	nickel cation binding
CpsigB_RS03465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CpsigB_RS03470	COG0829	nickel cation binding
CpsigB_RS03480	COG4139	cobalamin transport
CpsigB_RS03485	COG1120	ATPase activity
CpsigB_RS03500	COG2181	nitrate reductase activity
CpsigB_RS03500	COG0247	lactate metabolic process
CpsigB_RS03520	COG0601	transmembrane transport
CpsigB_RS03555	COG0443	Heat shock 70 kDa protein
CpsigB_RS03570	COG0789	Transcriptional regulator
CpsigB_RS03610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CpsigB_RS03615	COG1136	(ABC) transporter
CpsigB_RS03620	COG0577	efflux transmembrane transporter activity
CpsigB_RS03620	COG1136	(ABC) transporter
CpsigB_RS03640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CpsigB_RS03670	COG1131	(ABC) transporter
CpsigB_RS03710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CpsigB_RS03725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CpsigB_RS03740	COG0191	fructose-bisphosphate aldolase activity
CpsigB_RS03785	COG4129	membrane
CpsigB_RS03800	COG3005	denitrification pathway
CpsigB_RS03805	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CpsigB_RS03815	COG1333	cytochrome c biogenesis protein
CpsigB_RS03820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpsigB_RS03850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CpsigB_RS03855	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CpsigB_RS03875	COG0280	phosphate acetyltransferase
CpsigB_RS03890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpsigB_RS03915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CpsigB_RS03925	COG0456	acetyltransferase
CpsigB_RS03930	COG0242	peptide deformylase activity
CpsigB_RS03950	COG1051	belongs to the nudix hydrolase family
CpsigB_RS03970	COG0651	ATP synthesis coupled electron transport
CpsigB_RS03975	COG1006	Multisubunit Na H antiporter MnhC subunit
CpsigB_RS03980	COG2111	Na H antiporter
CpsigB_RS03980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpsigB_RS04020	COG2326	polyphosphate kinase activity
CpsigB_RS04025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CpsigB_RS04045	COG1301	dicarboxylic acid transport
CpsigB_RS04050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CpsigB_RS04050	COG0425	Belongs to the sulfur carrier protein TusA family
CpsigB_RS04055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CpsigB_RS04060	COG2027	D-alanyl-D-alanine carboxypeptidase
CpsigB_RS04070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CpsigB_RS04075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CpsigB_RS04080	COG0302	gtp cyclohydrolase
CpsigB_RS04085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpsigB_RS04115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CpsigB_RS04120	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CpsigB_RS04125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpsigB_RS04130	COG1012	belongs to the aldehyde dehydrogenase family
CpsigB_RS04135	COG1301	dicarboxylic acid transport
CpsigB_RS04150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpsigB_RS04165	COG1957	nucleoside hydrolase
CpsigB_RS04170	COG0477	Major facilitator Superfamily
CpsigB_RS04180	COG0542	response to heat
CpsigB_RS04200	COG0288	reversible hydration of carbon dioxide
CpsigB_RS04210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CpsigB_RS04225	COG2847	Copper chaperone PCu(A)C
CpsigB_RS04230	COG1329	Transcriptional regulator
CpsigB_RS04250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpsigB_RS04260	COG1609	Transcriptional regulator
CpsigB_RS04305	COG0028	Belongs to the TPP enzyme family
CpsigB_RS04335	COG0745	RESPONSE REGULATOR receiver
CpsigB_RS04340	COG2205	protein histidine kinase activity
CpsigB_RS04350	COG0537	adenosine 5'-monophosphoramidase activity
CpsigB_RS04355	COG0151	Belongs to the GarS family
CpsigB_RS04360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CpsigB_RS04365	COG0569	domain protein
CpsigB_RS04370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CpsigB_RS04390	COG0386	Belongs to the glutathione peroxidase family
CpsigB_RS04395	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpsigB_RS04400	COG0047	phosphoribosylformylglycinamidine synthase activity
CpsigB_RS04405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpsigB_RS04415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpsigB_RS04420	COG1780	Probably involved in ribonucleotide reductase function
CpsigB_RS04445	COG0354	folic acid binding
CpsigB_RS04460	COG1597	lipid kinase activity
CpsigB_RS04490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CpsigB_RS04515	COG1132	(ABC) transporter
CpsigB_RS04520	COG4988	ABC transporter
CpsigB_RS04525	COG1294	oxidase, subunit
CpsigB_RS04530	COG1271	oxidase subunit
CpsigB_RS04570	COG1045	serine acetyltransferase
CpsigB_RS04585	COG2197	response regulator
CpsigB_RS04620	COG0577	efflux transmembrane transporter activity
CpsigB_RS04620	COG1136	(ABC) transporter
CpsigB_RS04625	COG0577	efflux transmembrane transporter activity
CpsigB_RS04625	COG1136	(ABC) transporter
CpsigB_RS04640	COG0033	Phosphoglucomutase
CpsigB_RS04705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CpsigB_RS04725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpsigB_RS04735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpsigB_RS04780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CpsigB_RS04805	COG1234	tRNA 3'-trailer cleavage
CpsigB_RS04855	COG2197	response regulator
CpsigB_RS04900	COG1335	isochorismatase
CpsigB_RS04905	COG2130	NADP-dependent
CpsigB_RS04915	COG1376	ErfK ybiS ycfS ynhG family protein
CpsigB_RS04940	COG0604	alcohol dehydrogenase
CpsigB_RS04960	COG1966	Carbon starvation protein
CpsigB_RS04965	COG3336	cytochrome c oxidase
CpsigB_RS04970	COG1131	(ABC) transporter
CpsigB_RS05050	COG0668	transmembrane transport
CpsigB_RS05060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CpsigB_RS05095	COG0544	peptidyl-prolyl cis-trans isomerase activity
CpsigB_RS05135	COG0285	dihydrofolate synthase activity
CpsigB_RS05145	COG2423	ornithine cyclodeaminase activity
CpsigB_RS05160	COG1530	ribonuclease E activity
CpsigB_RS05185	COG0569	domain protein
CpsigB_RS05185	COG2985	domain, Protein
CpsigB_RS05190	COG2832	Protein of unknown function (DUF454)
CpsigB_RS05205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CpsigB_RS05215	COG0406	alpha-ribazole phosphatase activity
CpsigB_RS05220	COG1307	EDD domain protein, DegV family
CpsigB_RS05245	COG1280	lysine exporter protein (LysE YggA)
CpsigB_RS05270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpsigB_RS05275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpsigB_RS05295	COG0601	transmembrane transport
CpsigB_RS05305	COG2391	methyltransferase activity
CpsigB_RS05310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CpsigB_RS05320	COG4172	Belongs to the ABC transporter superfamily
CpsigB_RS05325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpsigB_RS05330	COG0601	transmembrane transport
CpsigB_RS05335	COG0747	negative chemotaxis
CpsigB_RS05350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpsigB_RS05360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpsigB_RS05365	COG1114	Component of the transport system for branched-chain amino acids
CpsigB_RS05420	COG1022	Amp-dependent synthetase and ligase
CpsigB_RS05475	COG1381	Involved in DNA repair and RecF pathway recombination
CpsigB_RS05505	COG0423	glycine-tRNA ligase activity
CpsigB_RS05575	COG2860	membrane
CpsigB_RS05605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CpsigB_RS05645	COG3323	Protein of unknown function (DUF1653)
CpsigB_RS05645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CpsigB_RS05665	COG0557	exoribonuclease II activity
CpsigB_RS05690	COG0174	glutamine synthetase
CpsigB_RS05715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CpsigB_RS05725	COG2056	Na+-H+ antiporter family
CpsigB_RS05875	COG0174	glutamine synthetase
CpsigB_RS05905	COG0509	glycine decarboxylation via glycine cleavage system
CpsigB_RS05910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CpsigB_RS05915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpsigB_RS05915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpsigB_RS05920	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpsigB_RS05935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CpsigB_RS05945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CpsigB_RS05950	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CpsigB_RS06000	COG0791	NLP P60 protein
CpsigB_RS06010	COG0438	transferase activity, transferring glycosyl groups
CpsigB_RS06015	COG1940	carbohydrate kinase activity
CpsigB_RS06035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CpsigB_RS06040	COG2815	serine threonine protein kinase
CpsigB_RS06040	COG0515	serine threonine protein kinase
CpsigB_RS06055	COG0142	geranyltranstransferase activity
CpsigB_RS06100	COG0768	penicillin binding
CpsigB_RS06105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CpsigB_RS06135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CpsigB_RS06145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CpsigB_RS06150	COG1496	oxidoreductase activity
CpsigB_RS06155	COG1799	cell septum assembly
CpsigB_RS06165	COG3599	regulation of cell shape
CpsigB_RS06185	COG0252	asparaginase activity
CpsigB_RS06200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CpsigB_RS06225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CpsigB_RS06230	COG1739	Uncharacterized protein family UPF0029
CpsigB_RS06255	COG2176	DNA-directed DNA polymerase activity
CpsigB_RS06320	COG0483	inositol monophosphate 1-phosphatase activity
CpsigB_RS06340	COG0134	indole-3-glycerol-phosphate synthase activity
CpsigB_RS06350	COG0469	pyruvate kinase activity
CpsigB_RS06360	COG0058	SHG alpha-glucan phosphorylase activity
CpsigB_RS06385	COG1929	Belongs to the glycerate kinase type-1 family
CpsigB_RS06390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CpsigB_RS06395	COG0686	Belongs to the AlaDH PNT family
CpsigB_RS06420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpsigB_RS06425	COG1115	amino acid carrier protein
CpsigB_RS06455	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CpsigB_RS06475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CpsigB_RS06480	COG0336	Belongs to the RNA methyltransferase TrmD family
CpsigB_RS06490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpsigB_RS06490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpsigB_RS06490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpsigB_RS06505	COG0681	Belongs to the peptidase S26 family
CpsigB_RS06530	COG4974	Belongs to the 'phage' integrase family
CpsigB_RS06585	COG0750	zinc metalloprotease
CpsigB_RS06650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CpsigB_RS06650	COG2169	Transcriptional regulator
CpsigB_RS06655	COG0523	cobalamin synthesis protein
CpsigB_RS06660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CpsigB_RS06665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpsigB_RS06665	COG1648	precorrin-2 dehydrogenase activity
CpsigB_RS06670	COG3022	response to hydroperoxide
CpsigB_RS06715	COG0534	Mate efflux family protein
CpsigB_RS06720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CpsigB_RS06730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CpsigB_RS06770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CpsigB_RS06780	COG1674	ftsk spoiiie
CpsigB_RS06805	COG1396	sequence-specific DNA binding
CpsigB_RS06810	COG1842	Phage shock protein A
CpsigB_RS06820	COG1122	ATPase activity
CpsigB_RS06825	COG1268	BioY protein
CpsigB_RS06835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CpsigB_RS06840	COG2137	regulation of response to DNA damage stimulus
CpsigB_RS06860	COG1196	nuclear chromosome segregation
CpsigB_RS06875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CpsigB_RS06890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CpsigB_RS06895	COG2233	PERMEase
CpsigB_RS06905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpsigB_RS06910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpsigB_RS06920	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CpsigB_RS06920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpsigB_RS06920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpsigB_RS06925	COG1105	Belongs to the carbohydrate kinase PfkB family
CpsigB_RS06930	COG1349	DNA-binding transcription factor activity
CpsigB_RS06935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CpsigB_RS06940	COG1349	DNA-binding transcription factor activity
CpsigB_RS06965	COG1643	Atp-dependent helicase
CpsigB_RS06980	COG0450	alkyl hydroperoxide reductase
CpsigB_RS06985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CpsigB_RS07055	COG2890	protein-(glutamine-N5) methyltransferase activity
CpsigB_RS07140	COG3253	May function as heme-dependent peroxidase
CpsigB_RS07145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CpsigB_RS07200	COG2837	iron assimilation
CpsigB_RS07215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CpsigB_RS07220	COG1560	Kdo2-lipid A biosynthetic process
CpsigB_RS07235	COG0156	8-amino-7-oxononanoate synthase activity
CpsigB_RS07250	COG1946	Acyl-CoA thioesterase
CpsigB_RS07280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpsigB_RS07285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpsigB_RS07300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CpsigB_RS07315	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CpsigB_RS07320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpsigB_RS07345	COG1760	l-serine dehydratase
CpsigB_RS07400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CpsigB_RS07420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CpsigB_RS07425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CpsigB_RS07430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CpsigB_RS07435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CpsigB_RS07440	COG0006	proline dipeptidase activity
CpsigB_RS07465	COG1090	epimerase
CpsigB_RS07480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CpsigB_RS07490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CpsigB_RS07535	COG0242	peptide deformylase activity
CpsigB_RS07550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CpsigB_RS07580	COG0322	excinuclease ABC activity
CpsigB_RS07590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CpsigB_RS07600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CpsigB_RS07620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpsigB_RS07640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CpsigB_RS07645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CpsigB_RS07690	COG0396	ATPase activity
CpsigB_RS07700	COG0822	iron-sulfur transferase activity
CpsigB_RS07705	COG2151	metal-sulfur cluster biosynthetic enzyme
CpsigB_RS07730	COG2848	UPF0210 protein
CpsigB_RS07760	COG0791	NLP P60 protein
CpsigB_RS07760	COG3883	PFAM NLP P60 protein
CpsigB_RS07825	COG0488	(ABC) transporter
CpsigB_RS07830	COG3842	ATPase activity
CpsigB_RS07840	COG2376	Dihydroxyacetone kinase
CpsigB_RS07845	COG1461	Dihydroxyacetone kinase
CpsigB_RS07870	COG0167	dihydroorotate dehydrogenase activity
CpsigB_RS07880	COG0667	Aldo Keto reductase
CpsigB_RS07900	COG0646	methionine synthase
CpsigB_RS07900	COG1410	methionine synthase
CpsigB_RS07920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpsigB_RS07925	COG1027	Aspartate ammonia-lyase
CpsigB_RS07945	COG1362	aminopeptidase activity
CpsigB_RS07960	COG4122	O-methyltransferase activity
CpsigB_RS07980	COG2378	regulation of single-species biofilm formation
CpsigB_RS07990	COG0805	protein transport
CpsigB_RS08005	COG0300	oxidoreductase activity
CpsigB_RS08055	COG0463	Glycosyl transferase, family 2
CpsigB_RS08080	COG0477	Major facilitator Superfamily
CpsigB_RS08100	COG0598	Magnesium transport protein CorA
CpsigB_RS08110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CpsigB_RS08115	COG0513	Belongs to the DEAD box helicase family
CpsigB_RS08120	COG1253	flavin adenine dinucleotide binding
CpsigB_RS08160	COG0653	protein targeting
CpsigB_RS08170	COG3012	SEC-C Motif Domain Protein
CpsigB_RS08195	COG3547	Transposase (IS116 IS110 IS902 family)
CpsigB_RS08205	COG4264	IucA IucC family
CpsigB_RS08210	COG1120	ATPase activity
CpsigB_RS08215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS08220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS08225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CpsigB_RS08230	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpsigB_RS08235	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpsigB_RS08240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CpsigB_RS08245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpsigB_RS08250	COG1160	GTP binding
CpsigB_RS08265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CpsigB_RS08275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CpsigB_RS08280	COG3104	oligopeptide transport
CpsigB_RS08300	COG4974	Belongs to the 'phage' integrase family
CpsigB_RS08305	COG0494	nUDIX hydrolase
CpsigB_RS08335	COG0647	UMP catabolic process
CpsigB_RS08370	COG2835	tetraacyldisaccharide 4'-kinase activity
CpsigB_RS08375	COG0165	Argininosuccinate lyase
CpsigB_RS08395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CpsigB_RS08410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CpsigB_RS08425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpsigB_RS08440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CpsigB_RS08455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpsigB_RS08465	COG3973	AAA domain
CpsigB_RS08485	COG0237	dephospho-CoA kinase activity
CpsigB_RS08495	COG0539	negative regulation of cytoplasmic translation
CpsigB_RS08500	COG2226	methyltransferase
CpsigB_RS08525	COG0765	amino acid transport
CpsigB_RS08550	COG0742	ribosomal rna small subunit methyltransferase
CpsigB_RS08555	COG0511	ligase activity, forming carbon-carbon bonds
CpsigB_RS08565	COG1461	Dihydroxyacetone kinase
CpsigB_RS08570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CpsigB_RS08575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CpsigB_RS08595	COG0406	alpha-ribazole phosphatase activity
CpsigB_RS08595	COG0494	nUDIX hydrolase
CpsigB_RS08650	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpsigB_RS08670	COG0473	3-isopropylmalate dehydrogenase activity
CpsigB_RS08710	COG0668	transmembrane transport
CpsigB_RS08735	COG0583	DNA-binding transcription factor activity
CpsigB_RS08745	COG0667	Aldo Keto reductase
CpsigB_RS08755	COG0205	6-phosphofructokinase activity
CpsigB_RS08765	COG1120	ATPase activity
CpsigB_RS08770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpsigB_RS08835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CpsigB_RS08855	COG1119	ATPase activity
CpsigB_RS08880	COG0346	lactoylglutathione lyase activity
CpsigB_RS08925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CpsigB_RS08930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CpsigB_RS08935	COG0356	it plays a direct role in the translocation of protons across the membrane
CpsigB_RS08985	COG0460	homoserine dehydrogenase
CpsigB_RS08990	COG0019	diaminopimelate decarboxylase activity
CpsigB_RS09000	COG1620	l-lactate permease
CpsigB_RS09005	COG0247	lactate metabolic process
CpsigB_RS09010	COG1139	Iron-sulfur cluster binding protein
CpsigB_RS09015	COG1556	Lactate utilization protein
CpsigB_RS09045	COG1846	Transcriptional regulator
CpsigB_RS09070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CpsigB_RS09075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpsigB_RS09105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CpsigB_RS09125	COG2017	converts alpha-aldose to the beta-anomer
CpsigB_RS09145	COG2272	Belongs to the type-B carboxylesterase lipase family
CpsigB_RS09150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CpsigB_RS09160	COG1132	(ABC) transporter
CpsigB_RS09165	COG0567	Dehydrogenase, E1 component
CpsigB_RS09165	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpsigB_RS09175	COG2239	Acts as a magnesium transporter
CpsigB_RS09205	COG4122	O-methyltransferase activity
CpsigB_RS09215	COG0297	glycogen (starch) synthase activity
CpsigB_RS09220	COG3527	Alpha-acetolactate decarboxylase
CpsigB_RS09245	COG0463	Glycosyl transferase, family 2
CpsigB_RS09250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpsigB_RS09255	COG1611	Belongs to the LOG family
CpsigB_RS09260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpsigB_RS09270	COG1113	amino acid transport
CpsigB_RS09280	COG1113	amino acid transport
CpsigB_RS09315	COG4166	transmembrane transport
CpsigB_RS09320	COG1217	gtp-binding protein TYPA
CpsigB_RS09350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpsigB_RS09360	COG4166	transmembrane transport
CpsigB_RS09370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CpsigB_RS09380	COG1122	ATPase activity
CpsigB_RS09385	COG4721	ABC-type cobalt transport system, permease component
CpsigB_RS09395	COG2354	Protein conserved in bacteria
CpsigB_RS09400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CpsigB_RS09410	COG1132	(ABC) transporter
CpsigB_RS09415	COG2824	Alkylphosphonate utilization operon protein PhnA
CpsigB_RS09430	COG0012	GTP binding
CpsigB_RS09465	COG1494	fructose-1,6-bisphosphatase
CpsigB_RS09470	COG0114	fumarate hydratase activity
CpsigB_RS09540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CpsigB_RS09600	COG3956	TIGRFAM MazG family protein
CpsigB_RS09605	COG0531	amino acid
CpsigB_RS09615	COG1309	transcriptional regulator
CpsigB_RS09625	COG2132	Multicopper oxidase
CpsigB_RS09630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CpsigB_RS09635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CpsigB_RS09640	COG1523	belongs to the glycosyl hydrolase 13 family
CpsigB_RS09660	COG2070	2-Nitropropane dioxygenase
CpsigB_RS09665	COG0193	aminoacyl-tRNA hydrolase activity
CpsigB_RS09675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CpsigB_RS09680	COG0596	Alpha beta hydrolase
CpsigB_RS09720	COG2326	polyphosphate kinase activity
CpsigB_RS09735	COG0488	(ABC) transporter
CpsigB_RS09750	COG3583	domain protein
CpsigB_RS09755	COG0084	hydrolase, TatD family'
CpsigB_RS09770	COG3949	Membrane
CpsigB_RS09775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpsigB_RS09785	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CpsigB_RS09795	COG2259	Doxx family
CpsigB_RS09815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CpsigB_RS09840	COG0315	cyclic pyranopterin monophosphate synthase activity
CpsigB_RS09840	COG0521	Mo-molybdopterin cofactor biosynthetic process
CpsigB_RS09845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CpsigB_RS09850	COG2205	protein histidine kinase activity
CpsigB_RS09855	COG0745	RESPONSE REGULATOR receiver
CpsigB_RS09865	COG0254	rRNA binding
CpsigB_RS09895	COG1309	transcriptional regulator
CpsigB_RS09905	COG0765	amino acid transport
CpsigB_RS09910	COG0765	amino acid transport
CpsigB_RS09915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpsigB_RS09920	COG1126	abc transporter atp-binding protein
CpsigB_RS09970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpsigB_RS09980	COG1201	RNA secondary structure unwinding
CpsigB_RS09985	COG1218	3'(2'),5'-bisphosphate nucleotidase
CpsigB_RS10000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CpsigB_RS10025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpsigB_RS10040	COG4166	transmembrane transport
CpsigB_RS10055	COG0019	diaminopimelate decarboxylase activity
CpsigB_RS10060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CpsigB_RS10065	COG0534	Mate efflux family protein
CpsigB_RS10080	COG3757	hydrolase, family 25
CpsigB_RS10090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpsigB_RS10100	COG1024	Enoyl-CoA hydratase
CpsigB_RS10105	COG0656	L-ascorbic acid biosynthetic process
CpsigB_RS10120	COG0545	Peptidyl-prolyl cis-trans isomerase
CpsigB_RS10125	COG0372	Belongs to the citrate synthase family
CpsigB_RS10145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpsigB_RS10150	COG2252	PERMEase
CpsigB_RS10175	COG1652	LysM domain
CpsigB_RS10185	COG1061	Type III restriction enzyme res subunit
CpsigB_RS10225	COG1131	(ABC) transporter
CpsigB_RS10240	COG1842	Phage shock protein A
CpsigB_RS10245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CpsigB_RS10260	COG0477	Major facilitator Superfamily
CpsigB_RS10265	COG0305	Participates in initiation and elongation during chromosome replication
CpsigB_RS10270	COG3387	PFAM Glycoside hydrolase 15-related
CpsigB_RS10285	COG0629	single-stranded DNA binding
CpsigB_RS10310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpsigB_RS10330	COG0300	oxidoreductase activity
CpsigB_RS10345	COG0586	Pfam SNARE associated Golgi protein
CpsigB_RS10350	COG0783	Belongs to the Dps family
CpsigB_RS10355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpsigB_RS10360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CpsigB_RS10360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CpsigB_RS10370	COG1511	domain protein
CpsigB_RS10380	COG1136	(ABC) transporter
CpsigB_RS10380	COG0577	efflux transmembrane transporter activity
CpsigB_RS10400	COG4585	Histidine kinase
CpsigB_RS10405	COG2197	response regulator
CpsigB_RS10420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CpsigB_RS10435	COG2186	Transcriptional regulator
CpsigB_RS10440	COG0747	negative chemotaxis
CpsigB_RS10445	COG0601	transmembrane transport
CpsigB_RS10450	COG0444	Belongs to the ABC transporter superfamily
CpsigB_RS10455	COG4608	Belongs to the ABC transporter superfamily
CpsigB_RS10460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CpsigB_RS10500	COG3422	double-strand break repair
CpsigB_RS10515	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CpsigB_RS10535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CpsigB_RS10540	COG0512	Glutamine amidotransferase of anthranilate synthase
CpsigB_RS10550	COG0134	indole-3-glycerol-phosphate synthase activity
CpsigB_RS10550	COG0135	phosphoribosylanthranilate isomerase activity
CpsigB_RS10580	COG1687	branched-chain amino acid
CpsigB_RS10585	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CpsigB_RS10590	COG1678	Uncharacterized ACR, COG1678
CpsigB_RS10595	COG0617	tRNA 3'-terminal CCA addition
CpsigB_RS10630	COG3409	Peptidoglycan-binding domain 1 protein
CpsigB_RS10630	COG0860	N-Acetylmuramoyl-L-alanine amidase
CpsigB_RS10645	COG1192	Involved in chromosome partitioning
CpsigB_RS10660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CpsigB_RS10670	COG0230	Belongs to the bacterial ribosomal protein bL34 family