locus-tag	class	description
CKALI_RS00010	COG0592	DNA-directed DNA polymerase activity
CKALI_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CKALI_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CKALI_RS00025	COG0187	DNA topoisomerase II activity
CKALI_RS00030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CKALI_RS00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CKALI_RS00105	COG2608	mercury ion transmembrane transporter activity
CKALI_RS00135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CKALI_RS00155	COG2815	serine threonine protein kinase
CKALI_RS00155	COG0515	serine threonine protein kinase
CKALI_RS00160	COG0515	serine threonine protein kinase
CKALI_RS00165	COG0768	penicillin binding
CKALI_RS00180	COG1716	ATPase activity
CKALI_RS00185	COG1716	ATPase activity
CKALI_RS00185	COG1716	ATPase activity
CKALI_RS00200	COG0789	Transcriptional regulator
CKALI_RS00220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CKALI_RS00230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CKALI_RS00265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CKALI_RS00340	COG5290	Psort location Cytoplasmic, score
CKALI_RS00410	COG0577	efflux transmembrane transporter activity
CKALI_RS00410	COG1136	(ABC) transporter
CKALI_RS00470	COG2124	cytochrome p450
CKALI_RS00475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CKALI_RS00490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CKALI_RS00520	COG0577	efflux transmembrane transporter activity
CKALI_RS00520	COG1136	(ABC) transporter
CKALI_RS00535	COG0438	transferase activity, transferring glycosyl groups
CKALI_RS00560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CKALI_RS00565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CKALI_RS00570	COG1086	Polysaccharide biosynthesis protein
CKALI_RS00575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CKALI_RS00580	COG0489	protein tyrosine kinase activity
CKALI_RS00605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CKALI_RS00615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CKALI_RS00630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CKALI_RS00645	COG3180	Ammonia monooxygenase
CKALI_RS00655	COG0671	phosphoesterase, PA-phosphatase related
CKALI_RS00660	COG3620	sequence-specific DNA binding
CKALI_RS00680	COG1643	Atp-dependent helicase
CKALI_RS00700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CKALI_RS00710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CKALI_RS00715	COG0798	PFAM Bile acid sodium symporter
CKALI_RS00730	COG2814	Major facilitator Superfamily
CKALI_RS00735	COG0583	DNA-binding transcription factor activity
CKALI_RS00755	COG2076	Multidrug Resistance protein
CKALI_RS00760	COG0431	NADPH-dependent FMN reductase
CKALI_RS00780	COG0519	Catalyzes the synthesis of GMP from XMP
CKALI_RS00790	COG0393	Putative heavy-metal-binding
CKALI_RS00795	COG2501	S4 domain
CKALI_RS00815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CKALI_RS00840	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CKALI_RS00850	COG3590	peptidase
CKALI_RS00870	COG0659	secondary active sulfate transmembrane transporter activity
CKALI_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
CKALI_RS00890	COG0277	FAD linked oxidase domain protein
CKALI_RS00925	COG1216	Glycosyl transferase, family 2
CKALI_RS00970	COG1316	TRANSCRIPTIONal
CKALI_RS00995	COG0154	amidase activity
CKALI_RS01000	COG0077	Prephenate dehydratase
CKALI_RS01020	COG2188	Transcriptional regulator
CKALI_RS01025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CKALI_RS01035	COG0561	phosphatase activity
CKALI_RS01060	COG1216	Glycosyl transferase, family 2
CKALI_RS01065	COG0671	phosphoesterase, PA-phosphatase related
CKALI_RS01070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CKALI_RS01080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CKALI_RS01080	COG5479	isomerase activity
CKALI_RS01090	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CKALI_RS01095	COG0318	PFAM AMP-dependent synthetase and ligase
CKALI_RS01100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CKALI_RS01100	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CKALI_RS01100	COG3321	synthase
CKALI_RS01105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CKALI_RS01130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CKALI_RS01140	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CKALI_RS01145	COG0500	methyltransferase
CKALI_RS01150	COG0438	transferase activity, transferring glycosyl groups
CKALI_RS01165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CKALI_RS01165	COG2755	lipolytic protein G-D-S-L family
CKALI_RS01180	COG4981	capsule polysaccharide biosynthetic process
CKALI_RS01195	COG1472	Belongs to the glycosyl hydrolase 3 family
CKALI_RS01205	COG0183	Belongs to the thiolase family
CKALI_RS01210	COG1024	Enoyl-CoA hydratase
CKALI_RS01225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CKALI_RS01235	COG1960	acyl-CoA dehydrogenase activity
CKALI_RS01255	COG0123	including yeast histone deacetylase and acetoin utilization protein
CKALI_RS01280	COG0084	hydrolase, TatD family'
CKALI_RS01285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CKALI_RS01300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CKALI_RS01345	COG2181	nitrate reductase activity
CKALI_RS01345	COG0247	lactate metabolic process
CKALI_RS01365	COG0484	heat shock protein binding
CKALI_RS01370	COG0789	Transcriptional regulator
CKALI_RS01405	COG0477	Major facilitator Superfamily
CKALI_RS01415	COG2072	flavoprotein involved in K transport
CKALI_RS01420	COG0542	response to heat
CKALI_RS01465	COG0191	fructose-bisphosphate aldolase activity
CKALI_RS01485	COG4129	membrane
CKALI_RS01505	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CKALI_RS01520	COG2153	protein acetylation
CKALI_RS01535	COG0280	phosphate acetyltransferase
CKALI_RS01550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CKALI_RS01565	COG1131	(ABC) transporter
CKALI_RS01580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CKALI_RS01605	COG0242	peptide deformylase activity
CKALI_RS01630	COG2212	antiporter activity
CKALI_RS01640	COG0651	ATP synthesis coupled electron transport
CKALI_RS01645	COG1006	Multisubunit Na H antiporter MnhC subunit
CKALI_RS01650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CKALI_RS01650	COG2111	Na H antiporter
CKALI_RS01665	COG0459	protein refolding
CKALI_RS01680	COG2326	polyphosphate kinase activity
CKALI_RS01720	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CKALI_RS01730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CKALI_RS01735	COG2027	D-alanyl-D-alanine carboxypeptidase
CKALI_RS01740	COG0037	tRNA processing
CKALI_RS01745	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CKALI_RS01750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CKALI_RS01755	COG0302	gtp cyclohydrolase
CKALI_RS01795	COG1959	2 iron, 2 sulfur cluster binding
CKALI_RS01800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CKALI_RS01800	COG1017	nitric oxide dioxygenase activity
CKALI_RS01805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CKALI_RS01815	COG3711	transcriptional antiterminator
CKALI_RS01840	COG0542	response to heat
CKALI_RS01850	COG1194	a g-specific adenine glycosylase
CKALI_RS01855	COG0288	reversible hydration of carbon dioxide
CKALI_RS01865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CKALI_RS01870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CKALI_RS01875	COG2847	Copper chaperone PCu(A)C
CKALI_RS01885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CKALI_RS01890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CKALI_RS01895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CKALI_RS01900	COG0215	cysteine-tRNA ligase activity
CKALI_RS01905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CKALI_RS01910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CKALI_RS01915	COG1121	(ABC) transporter
CKALI_RS01925	COG1609	Transcriptional regulator
CKALI_RS01965	COG0028	Belongs to the TPP enzyme family
CKALI_RS01970	COG1748	Saccharopine dehydrogenase
CKALI_RS01980	COG0789	Transcriptional regulator
CKALI_RS01980	COG4978	Transcriptional regulator
CKALI_RS01985	COG0745	RESPONSE REGULATOR receiver
CKALI_RS01990	COG5002	protein histidine kinase activity
CKALI_RS02000	COG0537	adenosine 5'-monophosphoramidase activity
CKALI_RS02005	COG0151	Belongs to the GarS family
CKALI_RS02010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CKALI_RS02015	COG0569	domain protein
CKALI_RS02020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CKALI_RS02035	COG1301	dicarboxylic acid transport
CKALI_RS02045	COG0386	Belongs to the glutathione peroxidase family
CKALI_RS02080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CKALI_RS02110	COG0456	acetyltransferase
CKALI_RS02125	COG0581	inorganic phosphate transmembrane transporter activity
CKALI_RS02130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CKALI_RS02150	COG4988	ABC transporter
CKALI_RS02155	COG4988	ABC transporter
CKALI_RS02160	COG1294	oxidase, subunit
CKALI_RS02165	COG1271	oxidase subunit
CKALI_RS02180	COG1136	(ABC) transporter
CKALI_RS02180	COG0577	efflux transmembrane transporter activity
CKALI_RS02235	COG1045	serine acetyltransferase
CKALI_RS02245	COG2197	response regulator
CKALI_RS02255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CKALI_RS02280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CKALI_RS02285	COG1115	amino acid carrier protein
CKALI_RS02290	COG0033	Phosphoglucomutase
CKALI_RS02320	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CKALI_RS02325	COG1140	nitrate reductase beta subunit
CKALI_RS02340	COG0521	Mo-molybdopterin cofactor biosynthetic process
CKALI_RS02340	COG0315	cyclic pyranopterin monophosphate synthase activity
CKALI_RS02350	COG0315	cyclic pyranopterin monophosphate synthase activity
CKALI_RS02370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CKALI_RS02405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CKALI_RS02410	COG2814	Major facilitator Superfamily
CKALI_RS02415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CKALI_RS02430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CKALI_RS02450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CKALI_RS02485	COG0318	PFAM AMP-dependent synthetase and ligase
CKALI_RS02520	COG0443	Heat shock 70 kDa protein
CKALI_RS02535	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CKALI_RS02540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CKALI_RS02550	COG3191	aminopeptidase activity
CKALI_RS02560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CKALI_RS02570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CKALI_RS02575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CKALI_RS02580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CKALI_RS02585	COG4608	Belongs to the ABC transporter superfamily
CKALI_RS02590	COG0444	Belongs to the ABC transporter superfamily
CKALI_RS02600	COG0747	negative chemotaxis
CKALI_RS02605	COG2186	Transcriptional regulator
CKALI_RS02655	COG2197	response regulator
CKALI_RS02665	COG1131	(ABC) transporter
CKALI_RS02675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CKALI_RS02685	COG3321	synthase
CKALI_RS02685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CKALI_RS02685	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CKALI_RS02695	COG3949	Membrane
CKALI_RS02710	COG1175	transmembrane transport
CKALI_RS02715	COG0395	ABC-type sugar transport system, permease component
CKALI_RS02725	COG3842	ATPase activity
CKALI_RS02730	COG0736	holo-[acyl-carrier-protein] synthase activity
CKALI_RS02750	COG1335	isochorismatase
CKALI_RS02765	COG1376	ErfK ybiS ycfS ynhG family protein
CKALI_RS02780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CKALI_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
CKALI_RS02800	COG3336	cytochrome c oxidase
CKALI_RS02830	COG0668	transmembrane transport
CKALI_RS02850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CKALI_RS02890	COG0544	peptidyl-prolyl cis-trans isomerase activity
CKALI_RS02920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CKALI_RS02930	COG0039	L-malate dehydrogenase activity
CKALI_RS02945	COG0525	valine-tRNA ligase activity
CKALI_RS02950	COG0443	Heat shock 70 kDa protein
CKALI_RS02955	COG0285	dihydrofolate synthase activity
CKALI_RS02970	COG0105	UTP biosynthetic process
CKALI_RS02975	COG1530	ribonuclease E activity
CKALI_RS03000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CKALI_RS03010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CKALI_RS03020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CKALI_RS03035	COG0406	alpha-ribazole phosphatase activity
CKALI_RS03040	COG1307	EDD domain protein, DegV family
CKALI_RS03060	COG1280	lysine exporter protein (LysE YggA)
CKALI_RS03065	COG0730	response to heat
CKALI_RS03085	COG0175	sulfate reduction
CKALI_RS03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CKALI_RS03130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CKALI_RS03135	COG1120	ATPase activity
CKALI_RS03155	COG3340	Belongs to the peptidase S51 family
CKALI_RS03175	COG1840	ABC-type Fe3 transport system, periplasmic component
CKALI_RS03180	COG1175	transmembrane transport
CKALI_RS03185	COG3842	ATPase activity
CKALI_RS03205	COG0154	amidase activity
CKALI_RS03215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CKALI_RS03220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CKALI_RS03255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CKALI_RS03255	COG4651	solute:proton antiporter activity
CKALI_RS03270	COG2390	Transcriptional regulator
CKALI_RS03275	COG0813	purine-nucleoside phosphorylase activity
CKALI_RS03280	COG2814	Major facilitator Superfamily
CKALI_RS03290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CKALI_RS03295	COG0438	transferase activity, transferring glycosyl groups
CKALI_RS03310	COG0601	transmembrane transport
CKALI_RS03315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CKALI_RS03320	COG1124	(ABC) transporter
CKALI_RS03345	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CKALI_RS03350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CKALI_RS03350	COG1473	amidohydrolase
CKALI_RS03365	COG2391	methyltransferase activity
CKALI_RS03375	COG0156	8-amino-7-oxononanoate synthase activity
CKALI_RS03385	COG2855	membrane
CKALI_RS03405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CKALI_RS03415	COG0747	negative chemotaxis
CKALI_RS03425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CKALI_RS03430	COG1114	Component of the transport system for branched-chain amino acids
CKALI_RS03435	COG1132	(ABC) transporter
CKALI_RS03455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CKALI_RS03465	COG0366	Alpha amylase catalytic
CKALI_RS03490	COG1022	Amp-dependent synthetase and ligase
CKALI_RS03525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CKALI_RS03540	COG1381	Involved in DNA repair and RecF pathway recombination
CKALI_RS03545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CKALI_RS03565	COG0423	glycine-tRNA ligase activity
CKALI_RS03675	COG1061	Type III restriction enzyme res subunit
CKALI_RS03715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CKALI_RS03725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CKALI_RS03745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CKALI_RS03760	COG0546	phosphoglycolate phosphatase activity
CKALI_RS03820	COG0174	glutamine synthetase
CKALI_RS03825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CKALI_RS03840	COG2271	Major facilitator Superfamily
CKALI_RS03875	COG0174	glutamine synthetase
CKALI_RS03885	COG2985	domain, Protein
CKALI_RS03885	COG0569	domain protein
CKALI_RS03910	COG0509	glycine decarboxylation via glycine cleavage system
CKALI_RS03915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CKALI_RS03920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CKALI_RS03920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CKALI_RS03925	COG0508	dehydrogenase complex catalyzes the overall conversion of
CKALI_RS03940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CKALI_RS03945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CKALI_RS03950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CKALI_RS03985	COG1845	cytochrome c oxidase, subunit III
CKALI_RS03990	COG2010	Cytochrome c
CKALI_RS03995	COG0723	plastoquinol--plastocyanin reductase activity
CKALI_RS04000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CKALI_RS04005	COG0791	NLP P60 protein
CKALI_RS04015	COG0438	transferase activity, transferring glycosyl groups
CKALI_RS04020	COG1940	carbohydrate kinase activity
CKALI_RS04040	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CKALI_RS04045	COG5650	phosphatidylinositol metabolic process
CKALI_RS04050	COG2815	serine threonine protein kinase
CKALI_RS04050	COG0515	serine threonine protein kinase
CKALI_RS04065	COG0142	geranyltranstransferase activity
CKALI_RS04105	COG0768	penicillin binding
CKALI_RS04110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CKALI_RS04120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CKALI_RS04125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CKALI_RS04135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CKALI_RS04140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CKALI_RS04145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CKALI_RS04150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CKALI_RS04155	COG1496	oxidoreductase activity
CKALI_RS04160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CKALI_RS04165	COG1799	cell septum assembly
CKALI_RS04170	COG2072	flavoprotein involved in K transport
CKALI_RS04180	COG3599	regulation of cell shape
CKALI_RS04190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CKALI_RS04205	COG0567	Dehydrogenase, E1 component
CKALI_RS04205	COG0508	dehydrogenase complex catalyzes the overall conversion of
CKALI_RS04210	COG1132	(ABC) transporter
CKALI_RS04220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CKALI_RS04240	COG2271	Major facilitator Superfamily
CKALI_RS04270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CKALI_RS04285	COG1113	amino acid transport
CKALI_RS04310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CKALI_RS04315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CKALI_RS04325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CKALI_RS04335	COG2353	YceI-like domain
CKALI_RS04360	COG1556	Lactate utilization protein
CKALI_RS04365	COG1139	Iron-sulfur cluster binding protein
CKALI_RS04370	COG0247	lactate metabolic process
CKALI_RS04375	COG1620	l-lactate permease
CKALI_RS04385	COG0019	diaminopimelate decarboxylase activity
CKALI_RS04390	COG0460	homoserine dehydrogenase
CKALI_RS04395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CKALI_RS04405	COG0318	PFAM AMP-dependent synthetase and ligase
CKALI_RS04410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CKALI_RS04410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CKALI_RS04430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CKALI_RS04440	COG0356	it plays a direct role in the translocation of protons across the membrane
CKALI_RS04445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CKALI_RS04450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CKALI_RS04485	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CKALI_RS04500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CKALI_RS04505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CKALI_RS04510	COG0366	Alpha amylase catalytic
CKALI_RS04515	COG1119	ATPase activity
CKALI_RS04535	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CKALI_RS04545	COG0310	cobalt ion transport
CKALI_RS04565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CKALI_RS04620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CKALI_RS04625	COG0450	alkyl hydroperoxide reductase
CKALI_RS04635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CKALI_RS04650	COG0154	amidase activity
CKALI_RS04655	COG1064	alcohol dehydrogenase
CKALI_RS04675	COG0205	6-phosphofructokinase activity
CKALI_RS04680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CKALI_RS04700	COG0583	DNA-binding transcription factor activity
CKALI_RS04715	COG0129	dihydroxy-acid dehydratase activity
CKALI_RS04725	COG0028	Belongs to the TPP enzyme family
CKALI_RS04735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CKALI_RS04750	COG0473	3-isopropylmalate dehydrogenase activity
CKALI_RS04765	COG0179	Fumarylacetoacetate (FAA) hydrolase
CKALI_RS04770	COG2813	Specifically methylates the guanine in position
CKALI_RS04830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CKALI_RS04840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CKALI_RS04845	COG0066	3-isopropylmalate dehydratase activity
CKALI_RS04855	COG0494	nUDIX hydrolase
CKALI_RS04855	COG0406	alpha-ribazole phosphatase activity
CKALI_RS04860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CKALI_RS04865	COG1181	Belongs to the D-alanine--D-alanine ligase family
CKALI_RS04875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CKALI_RS04880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CKALI_RS04885	COG1461	Dihydroxyacetone kinase
CKALI_RS04890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CKALI_RS04895	COG4770	biotin carboxylase activity
CKALI_RS04900	COG0742	ribosomal rna small subunit methyltransferase
CKALI_RS04905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CKALI_RS04915	COG1126	abc transporter atp-binding protein
CKALI_RS04920	COG0765	amino acid transport
CKALI_RS04925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CKALI_RS04935	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CKALI_RS04965	COG1073	alpha beta
CKALI_RS04965	COG2226	methyltransferase
CKALI_RS04970	COG0539	negative regulation of cytoplasmic translation
CKALI_RS04975	COG0237	dephospho-CoA kinase activity
CKALI_RS04980	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CKALI_RS05000	COG3973	AAA domain
CKALI_RS05010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CKALI_RS05055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CKALI_RS05070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CKALI_RS05075	COG0072	phenylalanine-tRNA ligase activity
CKALI_RS05075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CKALI_RS05080	COG2116	formate transmembrane transporter activity
CKALI_RS05085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CKALI_RS05100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CKALI_RS05115	COG0137	argininosuccinate synthase activity
CKALI_RS05130	COG2304	oxidoreductase activity
CKALI_RS05140	COG2835	tetraacyldisaccharide 4'-kinase activity
CKALI_RS05170	COG0647	UMP catabolic process
CKALI_RS05185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CKALI_RS05190	COG0497	DNA recombination
CKALI_RS05205	COG0494	nUDIX hydrolase
CKALI_RS05210	COG4974	Belongs to the 'phage' integrase family
CKALI_RS05220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CKALI_RS05230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CKALI_RS05235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CKALI_RS05250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CKALI_RS05255	COG1160	GTP binding
CKALI_RS05280	COG3012	SEC-C Motif Domain Protein
CKALI_RS05290	COG0653	protein targeting
CKALI_RS05295	COG1716	ATPase activity
CKALI_RS05330	COG1253	flavin adenine dinucleotide binding
CKALI_RS05340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CKALI_RS05355	COG0351	phosphomethylpyrimidine kinase
CKALI_RS05355	COG0352	thiamine-phosphate diphosphorylase activity
CKALI_RS05355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CKALI_RS05380	COG2318	DinB family
CKALI_RS05405	COG0463	Glycosyl transferase, family 2
CKALI_RS05450	COG3226	Transcriptional regulator
CKALI_RS05510	COG0300	oxidoreductase activity
CKALI_RS05515	COG3384	dioxygenase
CKALI_RS05535	COG0805	protein transport
CKALI_RS05545	COG2378	regulation of single-species biofilm formation
CKALI_RS05565	COG4122	O-methyltransferase activity
CKALI_RS05585	COG1362	aminopeptidase activity
CKALI_RS05590	COG0714	Associated with various cellular activities
CKALI_RS05595	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CKALI_RS05600	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CKALI_RS05610	COG3831	ATPase activity
CKALI_RS05640	COG3842	ATPase activity
CKALI_RS05645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CKALI_RS05650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CKALI_RS05655	COG1027	Aspartate ammonia-lyase
CKALI_RS05665	COG0140	phosphoribosyl-ATP diphosphatase activity
CKALI_RS05670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CKALI_RS05675	COG1410	methionine synthase
CKALI_RS05675	COG0646	methionine synthase
CKALI_RS05685	COG0215	cysteine-tRNA ligase activity
CKALI_RS05695	COG0667	Aldo Keto reductase
CKALI_RS05705	COG0167	dihydroorotate dehydrogenase activity
CKALI_RS05720	COG1132	(ABC) transporter
CKALI_RS05725	COG1132	(ABC) transporter
CKALI_RS05750	COG0662	Cupin 2, conserved barrel domain protein
CKALI_RS05800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CKALI_RS05805	COG0791	NLP P60 protein
CKALI_RS05805	COG3883	PFAM NLP P60 protein
CKALI_RS05825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CKALI_RS05825	COG0519	Catalyzes the synthesis of GMP from XMP
CKALI_RS05830	COG0363	glucosamine-6-phosphate deaminase activity
CKALI_RS05840	COG3830	Belongs to the UPF0237 family
CKALI_RS05845	COG2848	UPF0210 protein
CKALI_RS05855	COG0488	(ABC) transporter
CKALI_RS05870	COG2151	metal-sulfur cluster biosynthetic enzyme
CKALI_RS05875	COG0822	iron-sulfur transferase activity
CKALI_RS05885	COG0396	ATPase activity
CKALI_RS05910	COG1131	(ABC) transporter
CKALI_RS05930	COG0109	protoheme IX farnesyltransferase activity
CKALI_RS05935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CKALI_RS05940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CKALI_RS05955	COG0363	glucosamine-6-phosphate deaminase activity
CKALI_RS05965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CKALI_RS05970	COG0149	triose-phosphate isomerase activity
CKALI_RS05975	COG0126	phosphoglycerate kinase activity
CKALI_RS05980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CKALI_RS05985	COG1481	regulation of sporulation
CKALI_RS05990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CKALI_RS06000	COG0322	excinuclease ABC activity
CKALI_RS06010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CKALI_RS06045	COG0242	peptide deformylase activity
CKALI_RS06055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CKALI_RS06065	COG1758	RNA polymerase activity
CKALI_RS06070	COG0194	GDP metabolic process
CKALI_RS06080	COG0284	orotidine-5'-phosphate decarboxylase activity
CKALI_RS06085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CKALI_RS06090	COG0505	Belongs to the CarA family
CKALI_RS06095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CKALI_RS06105	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CKALI_RS06125	COG2326	polyphosphate kinase activity
CKALI_RS06130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CKALI_RS06135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CKALI_RS06140	COG0006	proline dipeptidase activity
CKALI_RS06145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CKALI_RS06150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CKALI_RS06155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CKALI_RS06160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CKALI_RS06170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CKALI_RS06175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CKALI_RS06180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CKALI_RS06230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CKALI_RS06240	COG1760	l-serine dehydratase
CKALI_RS06250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CKALI_RS06255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CKALI_RS06265	COG4085	toxin activity
CKALI_RS06265	COG1525	nuclease
CKALI_RS06265	COG0737	Belongs to the 5'-nucleotidase family
CKALI_RS06270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CKALI_RS06280	COG0747	negative chemotaxis
CKALI_RS06285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CKALI_RS06290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CKALI_RS06300	COG0632	four-way junction helicase activity
CKALI_RS06305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CKALI_RS06315	COG0217	transcriptional regulatory protein
CKALI_RS06320	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CKALI_RS06325	COG1946	Acyl-CoA thioesterase
CKALI_RS06335	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CKALI_RS06345	COG0438	transferase activity, transferring glycosyl groups
CKALI_RS06350	COG1560	Kdo2-lipid A biosynthetic process
CKALI_RS06355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CKALI_RS06365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CKALI_RS06480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CKALI_RS06485	COG3253	May function as heme-dependent peroxidase
CKALI_RS06500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CKALI_RS06505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CKALI_RS06520	COG0756	dUTP diphosphatase activity
CKALI_RS06540	COG1940	carbohydrate kinase activity
CKALI_RS06575	COG2890	protein-(glutamine-N5) methyltransferase activity
CKALI_RS06615	COG0583	DNA-binding transcription factor activity
CKALI_RS06620	COG1643	Atp-dependent helicase
CKALI_RS06635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CKALI_RS06640	COG1349	DNA-binding transcription factor activity
CKALI_RS06650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CKALI_RS06655	COG1349	DNA-binding transcription factor activity
CKALI_RS06665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CKALI_RS06665	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CKALI_RS06665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CKALI_RS06675	COG2233	PERMEase
CKALI_RS06680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CKALI_RS06705	COG1196	nuclear chromosome segregation
CKALI_RS06720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CKALI_RS06725	COG1126	abc transporter atp-binding protein
CKALI_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CKALI_RS06735	COG0765	amino acid transport
CKALI_RS06740	COG0765	amino acid transport
CKALI_RS06745	COG2137	regulation of response to DNA damage stimulus
CKALI_RS06760	COG1268	BioY protein
CKALI_RS06765	COG1122	ATPase activity
CKALI_RS06775	COG1842	Phage shock protein A
CKALI_RS06780	COG1396	sequence-specific DNA binding
CKALI_RS06805	COG1674	ftsk spoiiie
CKALI_RS06815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CKALI_RS06820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CKALI_RS06825	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CKALI_RS06845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CKALI_RS06855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CKALI_RS06865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CKALI_RS06870	COG0534	Mate efflux family protein
CKALI_RS06875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CKALI_RS06880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CKALI_RS06910	COG0442	prolyl-tRNA aminoacylation
CKALI_RS06920	COG3022	response to hydroperoxide
CKALI_RS06930	COG2409	Drug exporters of the RND superfamily
CKALI_RS06940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CKALI_RS06970	COG0579	oxidoreductase
CKALI_RS07005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CKALI_RS07010	COG0750	zinc metalloprotease
CKALI_RS07015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CKALI_RS07025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CKALI_RS07065	COG4974	Belongs to the 'phage' integrase family
CKALI_RS07080	COG0792	nuclease activity
CKALI_RS07095	COG0681	Belongs to the peptidase S26 family
CKALI_RS07110	COG0252	asparaginase activity
CKALI_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
CKALI_RS07125	COG1396	sequence-specific DNA binding
CKALI_RS07135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CKALI_RS07185	COG1254	Belongs to the acylphosphatase family
CKALI_RS07190	COG1115	amino acid carrier protein
CKALI_RS07195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CKALI_RS07200	COG0571	ribonuclease III activity
CKALI_RS07215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CKALI_RS07220	COG1929	Belongs to the glycerate kinase type-1 family
CKALI_RS07240	COG1802	Transcriptional regulator
CKALI_RS07245	COG0058	SHG alpha-glucan phosphorylase activity
CKALI_RS07250	COG0469	pyruvate kinase activity
CKALI_RS07255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CKALI_RS07260	COG0134	indole-3-glycerol-phosphate synthase activity
CKALI_RS07275	COG0107	imidazoleglycerol-phosphate synthase activity
CKALI_RS07280	COG0483	inositol monophosphate 1-phosphatase activity
CKALI_RS07285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CKALI_RS07305	COG0131	Imidazoleglycerol-phosphate dehydratase
CKALI_RS07395	COG1739	Uncharacterized protein family UPF0029
CKALI_RS07415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CKALI_RS07445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CKALI_RS07455	COG0488	(ABC) transporter
CKALI_RS07470	COG0252	asparaginase activity
CKALI_RS07490	COG0598	Magnesium transport protein CorA
CKALI_RS07500	COG2239	Acts as a magnesium transporter
CKALI_RS07515	COG2072	flavoprotein involved in K transport
CKALI_RS07520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CKALI_RS07530	COG1595	DNA-templated transcription, initiation
CKALI_RS07540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CKALI_RS07545	COG0297	glycogen (starch) synthase activity
CKALI_RS07550	COG1621	beta-fructofuranosidase activity
CKALI_RS07560	COG1621	beta-fructofuranosidase activity
CKALI_RS07585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CKALI_RS07600	COG1113	amino acid transport
CKALI_RS07605	COG1113	amino acid transport
CKALI_RS07610	COG1476	TRANSCRIPTIONal
CKALI_RS07650	COG0747	negative chemotaxis
CKALI_RS07660	COG1217	gtp-binding protein TYPA
CKALI_RS07685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CKALI_RS07690	COG0601	transmembrane transport
CKALI_RS07695	COG4166	transmembrane transport
CKALI_RS07710	COG1122	ATPase activity
CKALI_RS07715	COG4721	ABC-type cobalt transport system, permease component
CKALI_RS07730	COG2354	Protein conserved in bacteria
CKALI_RS07735	COG0428	transporter
CKALI_RS07770	COG0012	GTP binding
CKALI_RS07780	COG1322	Protein conserved in bacteria
CKALI_RS07800	COG1722	exodeoxyribonuclease VII activity
CKALI_RS07810	COG1494	fructose-1,6-bisphosphatase
CKALI_RS07815	COG0114	fumarate hydratase activity
CKALI_RS07820	COG1802	Transcriptional regulator
CKALI_RS07825	COG1914	H( )-stimulated, divalent metal cation uptake system
CKALI_RS07830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CKALI_RS07835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CKALI_RS07840	COG1984	allophanate hydrolase subunit 2
CKALI_RS07860	COG0577	efflux transmembrane transporter activity
CKALI_RS07865	COG1136	(ABC) transporter
CKALI_RS07875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CKALI_RS07910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CKALI_RS07920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CKALI_RS07980	COG3956	TIGRFAM MazG family protein
CKALI_RS07985	COG0531	amino acid
CKALI_RS07995	COG1309	transcriptional regulator
CKALI_RS08040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CKALI_RS08045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CKALI_RS08050	COG1902	pentaerythritol trinitrate reductase activity
CKALI_RS08055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CKALI_RS08060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CKALI_RS08065	COG0193	aminoacyl-tRNA hydrolase activity
CKALI_RS08070	COG0446	pyridine nucleotide-disulphide oxidoreductase
CKALI_RS08085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CKALI_RS08090	COG2409	Drug exporters of the RND superfamily
CKALI_RS08105	COG2409	Drug exporters of the RND superfamily
CKALI_RS08135	COG2326	polyphosphate kinase activity
CKALI_RS08140	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CKALI_RS08160	COG0577	efflux transmembrane transporter activity
CKALI_RS08160	COG1136	(ABC) transporter
CKALI_RS08175	COG0488	(ABC) transporter
CKALI_RS08190	COG3583	domain protein
CKALI_RS08195	COG0084	hydrolase, TatD family'
CKALI_RS08200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CKALI_RS08210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CKALI_RS08220	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CKALI_RS08240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CKALI_RS08250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CKALI_RS08255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CKALI_RS08265	COG1970	mechanosensitive ion channel activity
CKALI_RS08280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CKALI_RS08285	COG2205	protein histidine kinase activity
CKALI_RS08290	COG0745	RESPONSE REGULATOR receiver
CKALI_RS08310	COG4585	Histidine kinase
CKALI_RS08320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CKALI_RS08325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CKALI_RS08330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CKALI_RS08350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CKALI_RS08380	COG0318	PFAM AMP-dependent synthetase and ligase
CKALI_RS08390	COG2030	dehydratase
CKALI_RS08395	COG1960	acyl-CoA dehydrogenase activity
CKALI_RS08405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CKALI_RS08425	COG0446	pyridine nucleotide-disulphide oxidoreductase
CKALI_RS08440	COG0138	bifunctional purine biosynthesis protein purh
CKALI_RS08455	COG0739	heme binding
CKALI_RS08465	COG1605	Chorismate mutase
CKALI_RS08480	COG0586	Pfam SNARE associated Golgi protein
CKALI_RS08495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CKALI_RS08500	COG1201	RNA secondary structure unwinding
CKALI_RS08505	COG1218	3'(2'),5'-bisphosphate nucleotidase
CKALI_RS08525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CKALI_RS08560	COG3757	hydrolase, family 25
CKALI_RS08570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CKALI_RS08580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CKALI_RS08585	COG1024	Enoyl-CoA hydratase
CKALI_RS08590	COG0656	L-ascorbic acid biosynthetic process
CKALI_RS08595	COG1396	sequence-specific DNA binding
CKALI_RS08615	COG0545	Peptidyl-prolyl cis-trans isomerase
CKALI_RS08620	COG0372	Belongs to the citrate synthase family
CKALI_RS08640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CKALI_RS08645	COG2252	PERMEase
CKALI_RS08680	COG1652	LysM domain
CKALI_RS08690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CKALI_RS08705	COG1061	Type III restriction enzyme res subunit
CKALI_RS08750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CKALI_RS08775	COG2177	Part of the ABC transporter FtsEX involved in
CKALI_RS08780	COG2884	Cell division ATP-binding protein ftsE
CKALI_RS08800	COG0483	inositol monophosphate 1-phosphatase activity
CKALI_RS08805	COG0483	inositol monophosphate 1-phosphatase activity
CKALI_RS08890	COG3480	Lon protease (S16) C-terminal proteolytic domain
CKALI_RS08915	COG2816	NAD+ diphosphatase activity
CKALI_RS08920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CKALI_RS08920	COG0475	glutathione-regulated potassium exporter activity
CKALI_RS08925	COG0210	DNA helicase
CKALI_RS08965	COG1597	lipid kinase activity
CKALI_RS08985	COG1131	(ABC) transporter
CKALI_RS09000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CKALI_RS09005	COG2135	peptidase activity
CKALI_RS09010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CKALI_RS09055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CKALI_RS09065	COG5401	PFAM Sporulation and spore germination
CKALI_RS09070	COG5002	protein histidine kinase activity
CKALI_RS09075	COG0745	RESPONSE REGULATOR receiver
CKALI_RS09095	COG1482	cell wall glycoprotein biosynthetic process
CKALI_RS09125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CKALI_RS09135	COG1091	dTDP-4-dehydrorhamnose reductase activity
CKALI_RS09140	COG1316	TRANSCRIPTIONal
CKALI_RS09150	COG3842	ATPase activity
CKALI_RS09175	COG0298	carbon dioxide binding
CKALI_RS09180	COG3259	Nickel-dependent hydrogenase
CKALI_RS09190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CKALI_RS09215	COG0375	protein maturation
CKALI_RS09220	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CKALI_RS09230	COG0298	carbon dioxide binding
CKALI_RS09235	COG0409	Hydrogenase expression formation protein
CKALI_RS09240	COG1131	(ABC) transporter
CKALI_RS09250	COG4585	Histidine kinase
CKALI_RS09255	COG2197	response regulator
CKALI_RS09290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CKALI_RS09295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CKALI_RS09320	COG1297	OPT oligopeptide transporter protein
CKALI_RS09325	COG0039	L-malate dehydrogenase activity
CKALI_RS09335	COG2897	thiosulfate sulfurtransferase activity
CKALI_RS09340	COG4770	biotin carboxylase activity
CKALI_RS09360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CKALI_RS09365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CKALI_RS09370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CKALI_RS09385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CKALI_RS09385	COG1473	amidohydrolase
CKALI_RS09390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CKALI_RS09395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CKALI_RS09425	COG1295	ribonuclease BN
CKALI_RS09430	COG1404	Belongs to the peptidase S8 family
CKALI_RS09435	COG0180	Tryptophanyl-tRNA synthetase
CKALI_RS09440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CKALI_RS09445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CKALI_RS09465	COG2814	Major facilitator Superfamily
CKALI_RS09470	COG2838	Isocitrate dehydrogenase
CKALI_RS09485	COG1215	transferase activity, transferring glycosyl groups
CKALI_RS09495	COG3268	Saccharopine dehydrogenase
CKALI_RS09510	COG1966	Carbon starvation protein
CKALI_RS09515	COG2873	o-acetylhomoserine
CKALI_RS09520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CKALI_RS09530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CKALI_RS09535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CKALI_RS09550	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CKALI_RS09555	COG2860	membrane
CKALI_RS09560	COG0587	DNA-directed DNA polymerase activity
CKALI_RS09565	COG1464	Belongs to the NlpA lipoprotein family
CKALI_RS09575	COG2011	ABC-type metal ion transport system permease component
CKALI_RS09585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CKALI_RS09655	COG2197	response regulator
CKALI_RS09680	COG0516	GMP reductase activity
CKALI_RS09715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CKALI_RS09730	COG0456	acetyltransferase
CKALI_RS09745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CKALI_RS09755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CKALI_RS09810	COG1674	ftsk spoiiie
CKALI_RS09820	COG1404	Belongs to the peptidase S8 family
CKALI_RS09835	COG0101	tRNA pseudouridine synthase activity
CKALI_RS09855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CKALI_RS09885	COG0563	adenylate kinase activity
CKALI_RS09890	COG0201	protein transport
CKALI_RS09905	COG0200	Binds to the 23S rRNA
CKALI_RS09910	COG1841	ribosomal large subunit assembly
CKALI_RS09915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CKALI_RS09920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CKALI_RS09935	COG2610	gluconate transmembrane transporter activity
CKALI_RS09940	COG1309	transcriptional regulator
CKALI_RS09955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CKALI_RS09960	COG2224	Isocitrate lyase
CKALI_RS09975	COG0277	FAD linked oxidase domain protein
CKALI_RS10005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CKALI_RS10025	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CKALI_RS10075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CKALI_RS10085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CKALI_RS10090	COG0089	rRNA binding
CKALI_RS10105	COG0051	transcription antitermination factor activity, RNA binding
CKALI_RS10110	COG1302	Protein conserved in bacteria
CKALI_RS10165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CKALI_RS10210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CKALI_RS10245	COG0142	geranyltranstransferase activity
CKALI_RS10250	COG0644	oxidoreductase
CKALI_RS10255	COG2226	methyltransferase
CKALI_RS10260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CKALI_RS10260	COG0438	transferase activity, transferring glycosyl groups
CKALI_RS10270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CKALI_RS10275	COG4948	Mandelate Racemase Muconate Lactonizing
CKALI_RS10285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CKALI_RS10290	COG3949	Membrane
CKALI_RS10320	COG0640	Transcriptional regulator
CKALI_RS10325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CKALI_RS10330	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CKALI_RS10335	COG1088	dTDP-glucose 4,6-dehydratase activity
CKALI_RS10340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CKALI_RS10355	COG0785	Cytochrome C biogenesis protein
CKALI_RS10365	COG0406	alpha-ribazole phosphatase activity
CKALI_RS10375	COG2076	Multidrug Resistance protein
CKALI_RS10385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CKALI_RS10405	COG0113	porphobilinogen synthase activity
CKALI_RS10410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CKALI_RS10410	COG1648	precorrin-2 dehydrogenase activity
CKALI_RS10415	COG0181	hydroxymethylbilane synthase activity
CKALI_RS10420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CKALI_RS10445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CKALI_RS10470	COG5002	protein histidine kinase activity
CKALI_RS10485	COG0438	transferase activity, transferring glycosyl groups
CKALI_RS10490	COG0318	PFAM AMP-dependent synthetase and ligase
CKALI_RS10495	COG0318	PFAM AMP-dependent synthetase and ligase
CKALI_RS10520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CKALI_RS10525	COG0788	formyltetrahydrofolate deformylase activity
CKALI_RS10535	COG2733	membrane
CKALI_RS10545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CKALI_RS10550	COG1053	succinate dehydrogenase
CKALI_RS10560	COG1396	sequence-specific DNA binding
CKALI_RS10560	COG3800	Transcriptional regulator
CKALI_RS10570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CKALI_RS10575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CKALI_RS10575	COG5479	isomerase activity
CKALI_RS10585	COG1505	serine-type exopeptidase activity
CKALI_RS10600	COG1216	Glycosyl transferase, family 2
CKALI_RS10660	COG1754	DNA topoisomerase type I activity
CKALI_RS10660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CKALI_RS10670	COG1205	dead DEAH box helicase
CKALI_RS10670	COG1111	helicase
CKALI_RS10735	COG0494	nUDIX hydrolase
CKALI_RS10750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CKALI_RS10755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CKALI_RS10775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CKALI_RS10810	COG1937	Protein conserved in bacteria
CKALI_RS10820	COG2111	Na H antiporter
CKALI_RS10820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CKALI_RS10830	COG0651	ATP synthesis coupled electron transport
CKALI_RS10855	COG1764	response to oxidative stress
CKALI_RS10910	COG0527	aspartate kinase activity
CKALI_RS10915	COG0697	spore germination
CKALI_RS10925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CKALI_RS10940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CKALI_RS10945	COG1492	cobalamin metabolic process
CKALI_RS10965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CKALI_RS10990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CKALI_RS11045	COG0343	queuine tRNA-ribosyltransferase activity
CKALI_RS11050	COG2094	Belongs to the DNA glycosylase MPG family
CKALI_RS11055	COG2409	Drug exporters of the RND superfamily
CKALI_RS11065	COG3237	CsbD-like
CKALI_RS11080	COG0287	Prephenate dehydrogenase
CKALI_RS11390	COG4974	Belongs to the 'phage' integrase family
CKALI_RS11435	COG0469	pyruvate kinase activity
CKALI_RS11450	COG2197	response regulator
CKALI_RS11455	COG4585	Histidine kinase
CKALI_RS11470	COG0706	membrane insertase activity
CKALI_RS11495	COG1136	(ABC) transporter
CKALI_RS11495	COG0577	efflux transmembrane transporter activity
CKALI_RS11500	COG1136	(ABC) transporter
CKALI_RS11500	COG0577	efflux transmembrane transporter activity
CKALI_RS11505	COG1136	(ABC) transporter
CKALI_RS11505	COG0577	efflux transmembrane transporter activity
CKALI_RS11510	COG0577	efflux transmembrane transporter activity
CKALI_RS11515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CKALI_RS11565	COG1131	(ABC) transporter
CKALI_RS11570	COG2186	Transcriptional regulator
CKALI_RS11580	COG1842	Phage shock protein A
CKALI_RS11585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CKALI_RS11605	COG0179	Fumarylacetoacetate (FAA) hydrolase
CKALI_RS11610	COG0305	Participates in initiation and elongation during chromosome replication
CKALI_RS11615	COG1309	transcriptional regulator
CKALI_RS11630	COG0629	single-stranded DNA binding
CKALI_RS11635	COG0360	Binds together with S18 to 16S ribosomal RNA
CKALI_RS11650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CKALI_RS11655	COG1260	myo-inositol-1-phosphate synthase
CKALI_RS11670	COG0300	oxidoreductase activity
CKALI_RS11710	COG0668	transmembrane transport
CKALI_RS11745	COG0477	Major facilitator Superfamily
CKALI_RS11765	COG3396	Phenylacetate-CoA oxygenase
CKALI_RS11770	COG3460	Phenylacetate-CoA oxygenase
CKALI_RS11775	COG3396	Phenylacetate-CoA oxygenase
CKALI_RS11780	COG2151	metal-sulfur cluster biosynthetic enzyme
CKALI_RS11785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CKALI_RS11790	COG1024	Enoyl-CoA hydratase
CKALI_RS11795	COG0183	Belongs to the thiolase family
CKALI_RS11800	COG1024	Enoyl-CoA hydratase
CKALI_RS11805	COG1250	3-hydroxyacyl-CoA dehydrogenase
CKALI_RS11815	COG2030	dehydratase
CKALI_RS11815	COG1012	belongs to the aldehyde dehydrogenase family
CKALI_RS11825	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CKALI_RS11830	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CKALI_RS11840	COG5002	protein histidine kinase activity
CKALI_RS11860	COG2315	Protein conserved in bacteria
CKALI_RS11875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CKALI_RS11890	COG0352	thiamine-phosphate diphosphorylase activity
CKALI_RS11895	COG2022	thiamine diphosphate biosynthetic process
CKALI_RS11895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CKALI_RS11905	COG2022	thiamine diphosphate biosynthetic process
CKALI_RS11935	COG1012	belongs to the aldehyde dehydrogenase family
CKALI_RS11950	COG0495	leucyl-tRNA aminoacylation
CKALI_RS11975	COG1136	(ABC) transporter
CKALI_RS12000	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CKALI_RS12015	COG0133	tryptophan synthase activity
CKALI_RS12020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CKALI_RS12025	COG0512	Glutamine amidotransferase of anthranilate synthase
CKALI_RS12030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CKALI_RS12035	COG0134	indole-3-glycerol-phosphate synthase activity
CKALI_RS12035	COG0135	phosphoribosylanthranilate isomerase activity
CKALI_RS12060	COG1131	(ABC) transporter
CKALI_RS12075	COG1902	pentaerythritol trinitrate reductase activity
CKALI_RS12090	COG1678	Uncharacterized ACR, COG1678
CKALI_RS12095	COG0617	tRNA 3'-terminal CCA addition
CKALI_RS12115	COG1595	DNA-templated transcription, initiation
CKALI_RS12125	COG3118	belongs to the thioredoxin family
CKALI_RS12130	COG0860	N-Acetylmuramoyl-L-alanine amidase
CKALI_RS12130	COG3409	Peptidoglycan-binding domain 1 protein
CKALI_RS12145	COG1192	Involved in chromosome partitioning
CKALI_RS12155	COG0706	membrane insertase activity
CKALI_RS12160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CKALI_RS12165	COG0594	ribonuclease P activity
CKALI_RS12170	COG0230	Belongs to the bacterial ribosomal protein bL34 family