locus-tag	class	description
DR71_RS00005	COG1725	Transcriptional regulator
DR71_RS00010	COG1131	(ABC) transporter
DR71_RS00020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DR71_RS00030	COG0109	protoheme IX farnesyltransferase activity
DR71_RS00045	COG1131	(ABC) transporter
DR71_RS00070	COG0396	ATPase activity
DR71_RS00080	COG0822	iron-sulfur transferase activity
DR71_RS00090	COG0833	amino acid
DR71_RS00100	COG0488	(ABC) transporter
DR71_RS00130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DR71_RS00140	COG3883	PFAM NLP P60 protein
DR71_RS00140	COG0791	NLP P60 protein
DR71_RS00145	COG0714	Associated with various cellular activities
DR71_RS00155	COG2304	oxidoreductase activity
DR71_RS00160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DR71_RS00210	COG0640	Transcriptional regulator
DR71_RS00230	COG0167	dihydroorotate dehydrogenase activity
DR71_RS00245	COG1968	undecaprenyl-diphosphatase activity
DR71_RS00250	COG0215	cysteine-tRNA ligase activity
DR71_RS00260	COG1410	methionine synthase
DR71_RS00260	COG0646	methionine synthase
DR71_RS00270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR71_RS00285	COG1027	Aspartate ammonia-lyase
DR71_RS00290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DR71_RS00305	COG1222	aaa ATPase
DR71_RS00320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DR71_RS00340	COG0805	protein transport
DR71_RS00355	COG0318	PFAM AMP-dependent synthetase and ligase
DR71_RS00450	COG1253	flavin adenine dinucleotide binding
DR71_RS00460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DR71_RS00470	COG3573	Dehydrogenase
DR71_RS00490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DR71_RS00495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DR71_RS00495	COG0352	thiamine-phosphate diphosphorylase activity
DR71_RS00495	COG0351	phosphomethylpyrimidine kinase
DR71_RS00505	COG1253	flavin adenine dinucleotide binding
DR71_RS00540	COG1716	ATPase activity
DR71_RS00545	COG0653	protein targeting
DR71_RS00550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DR71_RS00565	COG1160	GTP binding
DR71_RS00575	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DR71_RS00580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DR71_RS00590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DR71_RS00610	COG0494	nUDIX hydrolase
DR71_RS00615	COG0504	CTP synthase activity
DR71_RS00625	COG0693	protein deglycase activity
DR71_RS00650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DR71_RS00660	COG1201	RNA secondary structure unwinding
DR71_RS00690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DR71_RS00705	COG0647	UMP catabolic process
DR71_RS00715	COG0328	RNA-DNA hybrid ribonuclease activity
DR71_RS00770	COG0165	Argininosuccinate lyase
DR71_RS00775	COG0137	argininosuccinate synthase activity
DR71_RS00780	COG1438	arginine binding
DR71_RS00785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DR71_RS00790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DR71_RS00795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DR71_RS00800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DR71_RS00805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DR71_RS00815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR71_RS00815	COG0072	phenylalanine-tRNA ligase activity
DR71_RS00820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DR71_RS00825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR71_RS00830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DR71_RS00835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DR71_RS00855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DR71_RS00895	COG1131	(ABC) transporter
DR71_RS00905	COG4585	Histidine kinase
DR71_RS00910	COG2197	response regulator
DR71_RS00925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DR71_RS00935	COG0237	dephospho-CoA kinase activity
DR71_RS00940	COG0435	Glutathione S-transferase
DR71_RS00950	COG0539	negative regulation of cytoplasmic translation
DR71_RS01005	COG2873	o-acetylhomoserine
DR71_RS01015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR71_RS01020	COG0765	amino acid transport
DR71_RS01025	COG1126	abc transporter atp-binding protein
DR71_RS01035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DR71_RS01050	COG1473	amidohydrolase
DR71_RS01055	COG0469	pyruvate kinase activity
DR71_RS01060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DR71_RS01065	COG0159	tryptophan synthase activity
DR71_RS01075	COG0134	indole-3-glycerol-phosphate synthase activity
DR71_RS01085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR71_RS01090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DR71_RS01095	COG0107	imidazoleglycerol-phosphate synthase activity
DR71_RS01100	COG0483	inositol monophosphate 1-phosphatase activity
DR71_RS01105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DR71_RS01110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DR71_RS01140	COG0131	Imidazoleglycerol-phosphate dehydratase
DR71_RS01145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DR71_RS01150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DR71_RS01175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DR71_RS01180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DR71_RS01200	COG1309	transcriptional regulator
DR71_RS01205	COG2056	Na+-H+ antiporter family
DR71_RS01265	COG1739	Uncharacterized protein family UPF0029
DR71_RS01280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DR71_RS01315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DR71_RS01330	COG0252	asparaginase activity
DR71_RS01340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DR71_RS01345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DR71_RS01350	COG3599	regulation of cell shape
DR71_RS01360	COG1799	cell septum assembly
DR71_RS01365	COG1496	oxidoreductase activity
DR71_RS01370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DR71_RS01380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DR71_RS01385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DR71_RS01395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DR71_RS01400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DR71_RS01410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DR71_RS01415	COG0768	penicillin binding
DR71_RS01425	COG0275	rRNA processing
DR71_RS01430	COG2001	Belongs to the MraZ family
DR71_RS01445	COG0456	acetyltransferase
DR71_RS01460	COG0142	geranyltranstransferase activity
DR71_RS01490	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DR71_RS01510	COG0438	transferase activity, transferring glycosyl groups
DR71_RS01520	COG0791	NLP P60 protein
DR71_RS01530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DR71_RS01545	COG0723	plastoquinol--plastocyanin reductase activity
DR71_RS01555	COG0488	(ABC) transporter
DR71_RS01590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DR71_RS01595	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DR71_RS01605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DR71_RS01610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DR71_RS01615	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR71_RS01625	COG0321	lipoyl(octanoyl) transferase activity
DR71_RS01640	COG2985	domain, Protein
DR71_RS01640	COG0569	domain protein
DR71_RS01650	COG0174	glutamine synthetase
DR71_RS01665	COG0174	glutamine synthetase
DR71_RS01670	COG1983	PspC domain protein
DR71_RS01685	COG2818	Glycosylase
DR71_RS01705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DR71_RS01710	COG1114	Component of the transport system for branched-chain amino acids
DR71_RS01720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DR71_RS01725	COG0028	Belongs to the TPP enzyme family
DR71_RS01730	COG2223	nitrite transmembrane transporter activity
DR71_RS01740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DR71_RS01745	COG0174	glutamine synthetase
DR71_RS01750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DR71_RS01780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DR71_RS01780	COG3323	Protein of unknown function (DUF1653)
DR71_RS01790	COG0546	phosphoglycolate phosphatase activity
DR71_RS01830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DR71_RS01850	COG1823	symporter activity
DR71_RS01855	COG0477	Major facilitator Superfamily
DR71_RS01865	COG1435	thymidine kinase activity
DR71_RS01870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DR71_RS01870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DR71_RS01900	COG3842	ATPase activity
DR71_RS01905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DR71_RS01915	COG1136	(ABC) transporter
DR71_RS01925	COG2197	response regulator
DR71_RS01930	COG1012	belongs to the aldehyde dehydrogenase family
DR71_RS01960	COG0358	DNA primase activity
DR71_RS01970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DR71_RS01990	COG0423	glycine-tRNA ligase activity
DR71_RS02000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DR71_RS02005	COG1381	Involved in DNA repair and RecF pathway recombination
DR71_RS02020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DR71_RS02025	COG1702	phosphate starvation-inducible protein PhoH
DR71_RS02040	COG1420	regulation of RNA biosynthetic process
DR71_RS02055	COG1022	Amp-dependent synthetase and ligase
DR71_RS02070	COG0339	signal peptide processing
DR71_RS02075	COG2272	Belongs to the type-B carboxylesterase lipase family
DR71_RS02080	COG3402	PFAM membrane-flanked domain
DR71_RS02090	COG0366	Alpha amylase catalytic
DR71_RS02100	COG1132	(ABC) transporter
DR71_RS02110	COG0277	FAD linked oxidase domain protein
DR71_RS02125	COG0671	phosphoesterase, PA-phosphatase related
DR71_RS02150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DR71_RS02155	COG1335	isochorismatase
DR71_RS02160	COG2354	Protein conserved in bacteria
DR71_RS02165	COG3012	SEC-C Motif Domain Protein
DR71_RS02175	COG2066	Belongs to the glutaminase family
DR71_RS02245	COG2217	Heavy metal translocating P-type atpase
DR71_RS02255	COG2205	protein histidine kinase activity
DR71_RS02260	COG0745	RESPONSE REGULATOR receiver
DR71_RS02270	COG2132	Multicopper oxidase
DR71_RS02295	COG0789	Transcriptional regulator
DR71_RS02315	COG0012	GTP binding
DR71_RS02335	COG1722	exodeoxyribonuclease VII activity
DR71_RS02345	COG1494	fructose-1,6-bisphosphatase
DR71_RS02350	COG0114	fumarate hydratase activity
DR71_RS02380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DR71_RS02385	COG1960	acyl-CoA dehydrogenase activity
DR71_RS02390	COG0733	neurotransmitter:sodium symporter activity
DR71_RS02400	COG1024	Enoyl-CoA hydratase
DR71_RS02420	COG1072	(Pantothenic acid kinase))
DR71_RS02430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR71_RS02440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DR71_RS02450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR71_RS02465	COG1012	belongs to the aldehyde dehydrogenase family
DR71_RS02490	COG0148	phosphopyruvate hydratase activity
DR71_RS02500	COG3956	TIGRFAM MazG family protein
DR71_RS02520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DR71_RS02525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DR71_RS02530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DR71_RS02535	COG0193	aminoacyl-tRNA hydrolase activity
DR71_RS02540	COG1132	(ABC) transporter
DR71_RS02545	COG1132	(ABC) transporter
DR71_RS02545	COG2375	cellular response to nickel ion
DR71_RS02550	COG2890	protein-(glutamine-N5) methyltransferase activity
DR71_RS02585	COG1122	ATPase activity
DR71_RS02610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DR71_RS02645	COG2326	polyphosphate kinase activity
DR71_RS02650	COG2177	Part of the ABC transporter FtsEX involved in
DR71_RS02655	COG2884	Cell division ATP-binding protein ftsE
DR71_RS02665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DR71_RS02670	COG0483	inositol monophosphate 1-phosphatase activity
DR71_RS02675	COG0483	inositol monophosphate 1-phosphatase activity
DR71_RS02685	COG0798	PFAM Bile acid sodium symporter
DR71_RS02690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DR71_RS02755	COG0659	secondary active sulfate transmembrane transporter activity
DR71_RS02770	COG1615	UPF0182 protein
DR71_RS02780	COG2755	lipolytic protein G-D-S-L family
DR71_RS02785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DR71_RS02790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DR71_RS02800	COG1230	cation diffusion facilitator family transporter
DR71_RS02805	COG0488	(ABC) transporter
DR71_RS02810	COG0494	nUDIX hydrolase
DR71_RS02820	COG3583	domain protein
DR71_RS02825	COG0084	hydrolase, TatD family'
DR71_RS02835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR71_RS02840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR71_RS02850	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
DR71_RS02880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DR71_RS02885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DR71_RS02895	COG1970	mechanosensitive ion channel activity
DR71_RS02905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR71_RS02910	COG2205	protein histidine kinase activity
DR71_RS02915	COG0745	RESPONSE REGULATOR receiver
DR71_RS02925	COG0254	rRNA binding
DR71_RS02930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DR71_RS02935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DR71_RS02940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DR71_RS02960	COG0069	glutamate synthase activity
DR71_RS02985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DR71_RS02990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DR71_RS03005	COG1476	TRANSCRIPTIONal
DR71_RS03015	COG0189	ligase activity
DR71_RS03025	COG4770	biotin carboxylase activity
DR71_RS03050	COG3415	Transposase
DR71_RS03050	COG2801	Transposase and inactivated derivatives
DR71_RS03070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DR71_RS03075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR71_RS03085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DR71_RS03095	COG0656	L-ascorbic acid biosynthetic process
DR71_RS03110	COG4152	abc transporter atp-binding protein
DR71_RS03115	COG1668	transmembrane transport
DR71_RS03120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR71_RS03130	COG0545	Peptidyl-prolyl cis-trans isomerase
DR71_RS03135	COG0372	Belongs to the citrate synthase family
DR71_RS03155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR71_RS03160	COG2252	PERMEase
DR71_RS03180	COG1278	Cold shock
DR71_RS03185	COG1652	LysM domain
DR71_RS03200	COG1061	Type III restriction enzyme res subunit
DR71_RS03265	COG2197	response regulator
DR71_RS03280	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
DR71_RS03285	COG0310	cobalt ion transport
DR71_RS03295	COG1045	serine acetyltransferase
DR71_RS03350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR71_RS03370	COG0456	acetyltransferase
DR71_RS03380	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DR71_RS03400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DR71_RS03415	COG1607	acyl-coa hydrolase
DR71_RS03430	COG0386	Belongs to the glutathione peroxidase family
DR71_RS03440	COG0778	Nitroreductase
DR71_RS03460	COG1028	Short-chain dehydrogenase reductase Sdr
DR71_RS03470	COG1780	Probably involved in ribonucleotide reductase function
DR71_RS03475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR71_RS03480	COG0431	NADPH-dependent FMN reductase
DR71_RS03500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DR71_RS03515	COG1126	abc transporter atp-binding protein
DR71_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR71_RS03525	COG0765	amino acid transport
DR71_RS03530	COG0765	amino acid transport
DR71_RS03535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR71_RS03550	COG2022	thiamine diphosphate biosynthetic process
DR71_RS03560	COG2022	thiamine diphosphate biosynthetic process
DR71_RS03560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR71_RS03565	COG0352	thiamine-phosphate diphosphorylase activity
DR71_RS03570	COG0569	domain protein
DR71_RS03575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR71_RS03580	COG0133	tryptophan synthase activity
DR71_RS03590	COG0436	Aminotransferase
DR71_RS03595	COG0151	Belongs to the GarS family
DR71_RS03600	COG0537	adenosine 5'-monophosphoramidase activity
DR71_RS03650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DR71_RS03655	COG1609	Transcriptional regulator
DR71_RS03665	COG1116	anion transmembrane transporter activity
DR71_RS03670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DR71_RS03675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR71_RS03690	COG2847	Copper chaperone PCu(A)C
DR71_RS03710	COG1194	a g-specific adenine glycosylase
DR71_RS03760	COG0443	Heat shock 70 kDa protein
DR71_RS03795	COG0318	PFAM AMP-dependent synthetase and ligase
DR71_RS03810	COG1960	acyl-CoA dehydrogenase activity
DR71_RS03815	COG1960	acyl-CoA dehydrogenase activity
DR71_RS03825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DR71_RS03835	COG3766	membrane
DR71_RS03860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DR71_RS03865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DR71_RS03890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DR71_RS03900	COG0302	gtp cyclohydrolase
DR71_RS03905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DR71_RS03915	COG0037	tRNA processing
DR71_RS03920	COG0154	amidase activity
DR71_RS03925	COG2027	D-alanyl-D-alanine carboxypeptidase
DR71_RS03930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DR71_RS03945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DR71_RS03950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DR71_RS03955	COG2837	iron assimilation
DR71_RS03960	COG2326	polyphosphate kinase activity
DR71_RS03985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DR71_RS03985	COG2111	Na H antiporter
DR71_RS03990	COG1006	Multisubunit Na H antiporter MnhC subunit
DR71_RS03995	COG0651	ATP synthesis coupled electron transport
DR71_RS04005	COG2212	antiporter activity
DR71_RS04035	COG0242	peptide deformylase activity
DR71_RS04075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR71_RS04080	COG0515	serine threonine protein kinase
DR71_RS04090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DR71_RS04095	COG0280	phosphate acetyltransferase
DR71_RS04110	COG2895	sulfate adenylyltransferase (ATP) activity
DR71_RS04125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DR71_RS04130	COG0730	response to heat
DR71_RS04140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DR71_RS04170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DR71_RS04185	COG4129	membrane
DR71_RS04210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DR71_RS04240	COG0542	response to heat
DR71_RS04245	COG3588	fructose-bisphosphate aldolase
DR71_RS04250	COG2860	membrane
DR71_RS04270	COG0789	Transcriptional regulator
DR71_RS04275	COG0484	heat shock protein binding
DR71_RS04280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DR71_RS04285	COG0443	Heat shock 70 kDa protein
DR71_RS04300	COG1024	Enoyl-CoA hydratase
DR71_RS04310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR71_RS04320	COG0247	lactate metabolic process
DR71_RS04320	COG2181	nitrate reductase activity
DR71_RS04330	COG2197	response regulator
DR71_RS04355	COG0431	NADPH-dependent FMN reductase
DR71_RS04380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DR71_RS04385	COG0717	Belongs to the dCTP deaminase family
DR71_RS04395	COG2197	response regulator
DR71_RS04405	COG2807	transmembrane transport
DR71_RS04420	COG4981	capsule polysaccharide biosynthetic process
DR71_RS04440	COG0438	transferase activity, transferring glycosyl groups
DR71_RS04445	COG0500	methyltransferase
DR71_RS04455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR71_RS04460	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR71_RS04465	COG1120	ATPase activity
DR71_RS04475	COG1764	response to oxidative stress
DR71_RS04480	COG0183	Belongs to the thiolase family
DR71_RS04485	COG1024	Enoyl-CoA hydratase
DR71_RS04485	COG1250	3-hydroxyacyl-CoA dehydrogenase
DR71_RS04495	COG2258	MOSC domain
DR71_RS04510	COG0601	transmembrane transport
DR71_RS04515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR71_RS04535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DR71_RS04545	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DR71_RS04560	COG2391	methyltransferase activity
DR71_RS04575	COG1012	belongs to the aldehyde dehydrogenase family
DR71_RS04580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR71_RS04585	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DR71_RS04590	COG2070	2-Nitropropane dioxygenase
DR71_RS04605	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DR71_RS04625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DR71_RS04645	COG3104	oligopeptide transport
DR71_RS04650	COG3830	Belongs to the UPF0237 family
DR71_RS04655	COG2848	UPF0210 protein
DR71_RS04665	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
DR71_RS04685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DR71_RS04690	COG0671	phosphoesterase, PA-phosphatase related
DR71_RS04695	COG1216	Glycosyl transferase, family 2
DR71_RS04725	COG0561	phosphatase activity
DR71_RS04735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DR71_RS04740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DR71_RS04745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DR71_RS04750	COG2267	carboxylic ester hydrolase activity
DR71_RS04755	COG1695	Transcriptional regulator
DR71_RS04770	COG3842	ATPase activity
DR71_RS04785	COG1280	lysine exporter protein (LysE YggA)
DR71_RS04810	COG0077	Prephenate dehydratase
DR71_RS04820	COG3001	Fructosamine kinase
DR71_RS04840	COG0469	pyruvate kinase activity
DR71_RS04910	COG0577	efflux transmembrane transporter activity
DR71_RS04910	COG1136	(ABC) transporter
DR71_RS04915	COG0577	efflux transmembrane transporter activity
DR71_RS04975	COG1842	Phage shock protein A
DR71_RS04985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DR71_RS05000	COG0305	Participates in initiation and elongation during chromosome replication
DR71_RS05005	COG0359	binds to the 23S rRNA
DR71_RS05010	COG0629	single-stranded DNA binding
DR71_RS05015	COG0360	Binds together with S18 to 16S ribosomal RNA
DR71_RS05025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR71_RS05030	COG1260	myo-inositol-1-phosphate synthase
DR71_RS05050	COG0495	leucyl-tRNA aminoacylation
DR71_RS05080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DR71_RS05085	COG1678	Uncharacterized ACR, COG1678
DR71_RS05090	COG0617	tRNA 3'-terminal CCA addition
DR71_RS05120	COG3118	belongs to the thioredoxin family
DR71_RS05125	COG0860	N-Acetylmuramoyl-L-alanine amidase
DR71_RS05125	COG3409	Peptidoglycan-binding domain 1 protein
DR71_RS05140	COG1192	Involved in chromosome partitioning
DR71_RS05145	COG0357	Ribosomal RNA small subunit methyltransferase G
DR71_RS05160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DR71_RS05165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DR71_RS05170	COG0592	DNA-directed DNA polymerase activity
DR71_RS05175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DR71_RS05180	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DR71_RS05185	COG0187	DNA topoisomerase II activity
DR71_RS05210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DR71_RS05245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DR71_RS05260	COG0515	serine threonine protein kinase
DR71_RS05260	COG2815	serine threonine protein kinase
DR71_RS05265	COG0515	serine threonine protein kinase
DR71_RS05270	COG0768	penicillin binding
DR71_RS05285	COG1716	ATPase activity
DR71_RS05290	COG1716	ATPase activity
DR71_RS05290	COG1716	ATPase activity
DR71_RS05305	COG5646	InterPro IPR014922
DR71_RS05340	COG2072	flavoprotein involved in K transport
DR71_RS05345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DR71_RS05350	COG0667	Aldo Keto reductase
DR71_RS05390	COG1518	maintenance of DNA repeat elements
DR71_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
DR71_RS05420	COG3268	Saccharopine dehydrogenase
DR71_RS05425	COG2814	Major facilitator Superfamily
DR71_RS05430	COG3177	Filamentation induced by cAMP protein fic
DR71_RS05440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DR71_RS05445	COG5650	phosphatidylinositol metabolic process
DR71_RS05450	COG1643	Atp-dependent helicase
DR71_RS05455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DR71_RS05465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DR71_RS05475	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR71_RS05475	COG1902	pentaerythritol trinitrate reductase activity
DR71_RS05490	COG0318	PFAM AMP-dependent synthetase and ligase
DR71_RS05500	COG0069	glutamate synthase activity
DR71_RS05500	COG0070	glutamate synthase
DR71_RS05500	COG0067	glutamate synthase
DR71_RS05535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DR71_RS05545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DR71_RS05560	COG2501	S4 domain
DR71_RS05570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DR71_RS05570	COG0473	3-isopropylmalate dehydrogenase activity
DR71_RS05585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR71_RS05590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DR71_RS05605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR71_RS05625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR71_RS05635	COG2390	Transcriptional regulator
DR71_RS05640	COG3590	peptidase
DR71_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
DR71_RS05670	COG0277	FAD linked oxidase domain protein
DR71_RS05695	COG1216	Glycosyl transferase, family 2
DR71_RS05710	COG1216	Glycosyl transferase, family 2
DR71_RS05730	COG0604	alcohol dehydrogenase
DR71_RS05730	COG4221	oxidoreductase activity
DR71_RS05730	COG3321	synthase
DR71_RS05730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DR71_RS05765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DR71_RS05775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DR71_RS05780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DR71_RS05785	COG0287	Prephenate dehydrogenase
DR71_RS05800	COG3237	CsbD-like
DR71_RS05805	COG1748	Saccharopine dehydrogenase
DR71_RS05815	COG2409	Drug exporters of the RND superfamily
DR71_RS05820	COG0343	queuine tRNA-ribosyltransferase activity
DR71_RS05825	COG1131	(ABC) transporter
DR71_RS05845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR71_RS05880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DR71_RS05900	COG1937	Protein conserved in bacteria
DR71_RS05930	COG0659	secondary active sulfate transmembrane transporter activity
DR71_RS05935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR71_RS05955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DR71_RS05960	COG3442	glutamine amidotransferase
DR71_RS05965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DR71_RS05980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DR71_RS05990	COG1511	domain protein
DR71_RS06000	COG0697	spore germination
DR71_RS06005	COG0527	aspartate kinase activity
DR71_RS06095	COG4591	ABC-type transport system involved in lipoprotein release permease component
DR71_RS06095	COG1136	(ABC) transporter
DR71_RS06135	COG0651	ATP synthesis coupled electron transport
DR71_RS06140	COG1006	Multisubunit Na H antiporter MnhC subunit
DR71_RS06145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DR71_RS06145	COG2111	Na H antiporter
DR71_RS06155	COG1408	metallophosphoesterase
DR71_RS06185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR71_RS06245	COG3415	Transposase
DR71_RS06245	COG2801	Transposase and inactivated derivatives
DR71_RS06255	COG0697	spore germination
DR71_RS06260	COG0583	DNA-binding transcription factor activity
DR71_RS06295	COG1002	Type II restriction enzyme, methylase subunits
DR71_RS06320	COG1111	helicase
DR71_RS06320	COG1205	dead DEAH box helicase
DR71_RS06330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR71_RS06330	COG1754	DNA topoisomerase type I activity
DR71_RS06345	COG3655	Transcriptional regulator
DR71_RS06355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DR71_RS06385	COG0477	Major facilitator Superfamily
DR71_RS06390	COG2814	Major facilitator Superfamily
DR71_RS06395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DR71_RS06430	COG1505	serine-type exopeptidase activity
DR71_RS06435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR71_RS06440	COG1396	sequence-specific DNA binding
DR71_RS06440	COG3800	Transcriptional regulator
DR71_RS06445	COG2224	Isocitrate lyase
DR71_RS06450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DR71_RS06470	COG1053	succinate dehydrogenase
DR71_RS06475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DR71_RS06485	COG2733	membrane
DR71_RS06495	COG0788	formyltetrahydrofolate deformylase activity
DR71_RS06515	COG0318	PFAM AMP-dependent synthetase and ligase
DR71_RS06520	COG0438	transferase activity, transferring glycosyl groups
DR71_RS06530	COG0588	phosphoglycerate mutase activity
DR71_RS06535	COG5002	protein histidine kinase activity
DR71_RS06560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DR71_RS06580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DR71_RS06585	COG0181	hydroxymethylbilane synthase activity
DR71_RS06620	COG0406	alpha-ribazole phosphatase activity
DR71_RS06635	COG1333	cytochrome c biogenesis protein
DR71_RS06640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DR71_RS06645	COG1088	dTDP-glucose 4,6-dehydratase activity
DR71_RS06650	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DR71_RS06655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DR71_RS06690	COG3949	Membrane
DR71_RS06700	COG1131	(ABC) transporter
DR71_RS06705	COG2197	response regulator
DR71_RS06710	COG4585	Histidine kinase
DR71_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
DR71_RS06725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DR71_RS06735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DR71_RS06740	COG4948	Mandelate Racemase Muconate Lactonizing
DR71_RS06745	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DR71_RS06755	COG0438	transferase activity, transferring glycosyl groups
DR71_RS06755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DR71_RS06765	COG0644	oxidoreductase
DR71_RS06770	COG0142	geranyltranstransferase activity
DR71_RS06800	COG0250	Participates in transcription elongation, termination and antitermination
DR71_RS06805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DR71_RS06820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DR71_RS06825	COG0222	ribosome binding
DR71_RS06835	COG0085	RNA polymerase activity
DR71_RS06840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DR71_RS06845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DR71_RS06845	COG0519	Catalyzes the synthesis of GMP from XMP
DR71_RS06855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DR71_RS06860	COG0830	nickel cation binding
DR71_RS06865	COG0804	urea catabolic process
DR71_RS06875	COG0831	urea catabolic process
DR71_RS06895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DR71_RS06910	COG0049	tRNA binding
DR71_RS06920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DR71_RS06925	COG0051	transcription antitermination factor activity, RNA binding
DR71_RS06930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DR71_RS06935	COG0088	Forms part of the polypeptide exit tunnel
DR71_RS06940	COG0089	rRNA binding
DR71_RS06945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DR71_RS06950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DR71_RS06955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DR71_RS06960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DR71_RS06965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DR71_RS06970	COG0255	Belongs to the universal ribosomal protein uL29 family
DR71_RS06980	COG2239	Acts as a magnesium transporter
DR71_RS06985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DR71_RS07000	COG2814	Major facilitator Superfamily
DR71_RS07010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DR71_RS07030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DR71_RS07040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DR71_RS07045	COG1841	ribosomal large subunit assembly
DR71_RS07050	COG0200	Binds to the 23S rRNA
DR71_RS07055	COG0156	8-amino-7-oxononanoate synthase activity
DR71_RS07060	COG0201	protein transport
DR71_RS07065	COG0563	adenylate kinase activity
DR71_RS07080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DR71_RS07085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DR71_RS07090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DR71_RS07095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DR71_RS07130	COG1404	Belongs to the peptidase S8 family
DR71_RS07140	COG1674	ftsk spoiiie
DR71_RS07165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DR71_RS07170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DR71_RS07170	COG2755	lipolytic protein G-D-S-L family
DR71_RS07180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR71_RS07185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DR71_RS07210	COG3425	synthase
DR71_RS07235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DR71_RS07250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DR71_RS07250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DR71_RS07255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DR71_RS07260	COG1214	PFAM Peptidase M22, glycoprotease
DR71_RS07260	COG0456	acetyltransferase
DR71_RS07265	COG0456	acetyltransferase
DR71_RS07270	COG0028	Belongs to the TPP enzyme family
DR71_RS07285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DR71_RS07290	COG0459	protein refolding
DR71_RS07310	COG0516	GMP reductase activity
DR71_RS07320	COG0519	Catalyzes the synthesis of GMP from XMP
DR71_RS07320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DR71_RS07340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DR71_RS07355	COG2011	ABC-type metal ion transport system permease component
DR71_RS07360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DR71_RS07365	COG1464	Belongs to the NlpA lipoprotein family
DR71_RS07370	COG0587	DNA-directed DNA polymerase activity
DR71_RS07380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DR71_RS07385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DR71_RS07395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DR71_RS07400	COG2873	o-acetylhomoserine
DR71_RS07405	COG2838	Isocitrate dehydrogenase
DR71_RS07415	COG2814	Major facilitator Superfamily
DR71_RS07435	COG0180	Tryptophanyl-tRNA synthetase
DR71_RS07440	COG1295	ribonuclease BN
DR71_RS07445	COG1686	Belongs to the peptidase S11 family
DR71_RS07460	COG0791	NLP P60 protein
DR71_RS07485	COG1473	amidohydrolase
DR71_RS07485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DR71_RS07495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DR71_RS07500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DR71_RS07505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DR71_RS07510	COG1218	3'(2'),5'-bisphosphate nucleotidase
DR71_RS07525	COG1605	Chorismate mutase
DR71_RS07555	COG0138	bifunctional purine biosynthesis protein purh
DR71_RS07565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DR71_RS07575	COG1960	acyl-CoA dehydrogenase activity
DR71_RS07590	COG0318	PFAM AMP-dependent synthetase and ligase
DR71_RS07595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DR71_RS07605	COG0183	Belongs to the thiolase family
DR71_RS07615	COG0409	Hydrogenase expression formation protein
DR71_RS07620	COG0298	carbon dioxide binding
DR71_RS07625	COG0309	Hydrogenase expression formation protein (HypE)
DR71_RS07630	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DR71_RS07635	COG0375	protein maturation
DR71_RS07650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DR71_RS07660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DR71_RS07665	COG0375	protein maturation
DR71_RS07670	COG3259	Nickel-dependent hydrogenase
DR71_RS07680	COG1316	TRANSCRIPTIONal
DR71_RS07725	COG1482	cell wall glycoprotein biosynthetic process
DR71_RS07740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DR71_RS07755	COG5002	protein histidine kinase activity
DR71_RS07770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR71_RS07775	COG0653	protein targeting
DR71_RS07810	COG1162	GTPase activity
DR71_RS07815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DR71_RS07825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DR71_RS07835	COG5662	AntiSigma factor
DR71_RS07850	COG1597	lipid kinase activity
DR71_RS07865	COG0513	Belongs to the DEAD box helicase family
DR71_RS07885	COG0210	DNA helicase
DR71_RS07890	COG0210	DNA helicase
DR71_RS07920	COG3480	Lon protease (S16) C-terminal proteolytic domain
DR71_RS07925	COG1115	amino acid carrier protein
DR71_RS07935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DR71_RS07970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DR71_RS07975	COG2814	Major facilitator Superfamily
DR71_RS07980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DR71_RS07995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR71_RS08005	COG2814	Major facilitator Superfamily
DR71_RS08010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR71_RS08015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DR71_RS08020	COG0560	Phosphoserine phosphatase
DR71_RS08020	COG3830	Belongs to the UPF0237 family
DR71_RS08030	COG0318	PFAM AMP-dependent synthetase and ligase
DR71_RS08040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DR71_RS08045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DR71_RS08055	COG3191	aminopeptidase activity
DR71_RS08065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DR71_RS08075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DR71_RS08165	COG1376	ErfK ybiS ycfS ynhG family protein
DR71_RS08170	COG2197	response regulator
DR71_RS08175	COG4585	Histidine kinase
DR71_RS08180	COG0577	efflux transmembrane transporter activity
DR71_RS08185	COG0577	efflux transmembrane transporter activity
DR71_RS08185	COG1136	(ABC) transporter
DR71_RS08195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DR71_RS08210	COG3336	cytochrome c oxidase
DR71_RS08215	COG0629	single-stranded DNA binding
DR71_RS08245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DR71_RS08250	COG0535	radical SAM domain protein
DR71_RS08255	COG0698	ribose 5-phosphate isomerase
DR71_RS08285	COG0544	peptidyl-prolyl cis-trans isomerase activity
DR71_RS08290	COG0740	serine-type endopeptidase activity
DR71_RS08295	COG0740	serine-type endopeptidase activity
DR71_RS08310	COG0039	L-malate dehydrogenase activity
DR71_RS08315	COG0525	valine-tRNA ligase activity
DR71_RS08320	COG0285	dihydrofolate synthase activity
DR71_RS08335	COG1530	ribonuclease E activity
DR71_RS08340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DR71_RS08345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DR71_RS08350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DR71_RS08355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DR71_RS08360	COG3764	Sortase (surface protein transpeptidase)
DR71_RS08370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DR71_RS08375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DR71_RS08385	COG0406	alpha-ribazole phosphatase activity
DR71_RS08390	COG1307	EDD domain protein, DegV family
DR71_RS08415	COG0268	Binds directly to 16S ribosomal RNA
DR71_RS08435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DR71_RS08435	COG4651	solute:proton antiporter activity
DR71_RS08445	COG0406	alpha-ribazole phosphatase activity
DR71_RS08465	COG0363	glucosamine-6-phosphate deaminase activity
DR71_RS08500	COG2130	NADP-dependent
DR71_RS08510	COG2860	membrane
DR71_RS08520	COG1132	(ABC) transporter
DR71_RS08525	COG1132	(ABC) transporter
DR71_RS08540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR71_RS08550	COG2271	Major facilitator Superfamily
DR71_RS08555	COG1393	Belongs to the ArsC family
DR71_RS08565	COG1121	(ABC) transporter
DR71_RS08570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DR71_RS08580	COG1321	iron dependent repressor
DR71_RS08595	COG3321	synthase
DR71_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
DR71_RS08595	COG0604	alcohol dehydrogenase
DR71_RS08605	COG1914	H( )-stimulated, divalent metal cation uptake system
DR71_RS08610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DR71_RS08615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DR71_RS08620	COG1984	allophanate hydrolase subunit 2
DR71_RS08630	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DR71_RS08635	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DR71_RS08645	COG1309	transcriptional regulator
DR71_RS08650	COG0477	Major facilitator Superfamily
DR71_RS08665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DR71_RS08685	COG1362	aminopeptidase activity
DR71_RS08690	COG1473	amidohydrolase
DR71_RS08695	COG0366	Alpha amylase catalytic
DR71_RS08710	COG4721	ABC-type cobalt transport system, permease component
DR71_RS08715	COG4172	Belongs to the ABC transporter superfamily
DR71_RS08760	COG1217	gtp-binding protein TYPA
DR71_RS08765	COG4166	transmembrane transport
DR71_RS08770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DR71_RS08790	COG0564	pseudouridine synthase activity
DR71_RS08800	COG1113	amino acid transport
DR71_RS08815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DR71_RS08820	COG1611	Belongs to the LOG family
DR71_RS08825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DR71_RS08835	COG3527	Alpha-acetolactate decarboxylase
DR71_RS08845	COG0297	glycogen (starch) synthase activity
DR71_RS08850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DR71_RS08855	COG4122	O-methyltransferase activity
DR71_RS08870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR71_RS08875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DR71_RS08890	COG0598	Magnesium transport protein CorA
DR71_RS08900	COG0567	Dehydrogenase, E1 component
DR71_RS08900	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR71_RS08905	COG1132	(ABC) transporter
DR71_RS08945	COG0494	nUDIX hydrolase
DR71_RS08955	COG0385	Bile acid
DR71_RS08975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR71_RS08980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DR71_RS08990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DR71_RS09015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR71_RS09020	COG1120	ATPase activity
DR71_RS09030	COG1556	Lactate utilization protein
DR71_RS09035	COG1139	Iron-sulfur cluster binding protein
DR71_RS09040	COG0247	lactate metabolic process
DR71_RS09045	COG0018	arginyl-trna synthetase
DR71_RS09050	COG0019	diaminopimelate decarboxylase activity
DR71_RS09055	COG0460	homoserine dehydrogenase
DR71_RS09060	COG0083	homoserine kinase activity
DR71_RS09065	COG0318	PFAM AMP-dependent synthetase and ligase
DR71_RS09075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DR71_RS09090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DR71_RS09100	COG0356	it plays a direct role in the translocation of protons across the membrane
DR71_RS09105	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DR71_RS09110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DR71_RS09115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DR71_RS09120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DR71_RS09125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DR71_RS09130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DR71_RS09185	COG0366	Alpha amylase catalytic
DR71_RS09190	COG1119	ATPase activity
DR71_RS09210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DR71_RS09220	COG0482	sulfurtransferase activity
DR71_RS09235	COG2409	Drug exporters of the RND superfamily
DR71_RS09250	COG0058	SHG alpha-glucan phosphorylase activity
DR71_RS09260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DR71_RS09265	COG0154	amidase activity
DR71_RS09270	COG4139	cobalamin transport
DR71_RS09275	COG1120	ATPase activity
DR71_RS09285	COG0205	6-phosphofructokinase activity
DR71_RS09290	COG3949	Membrane
DR71_RS09300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DR71_RS09320	COG0129	dihydroxy-acid dehydratase activity
DR71_RS09330	COG0668	transmembrane transport
DR71_RS09335	COG0028	Belongs to the TPP enzyme family
DR71_RS09345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DR71_RS09365	COG0523	cobalamin synthesis protein
DR71_RS09380	COG0473	3-isopropylmalate dehydrogenase activity
DR71_RS09400	COG0179	Fumarylacetoacetate (FAA) hydrolase
DR71_RS09415	COG3622	Belongs to the hyi family
DR71_RS09420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR71_RS09450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DR71_RS09465	COG0039	L-malate dehydrogenase activity
DR71_RS09480	COG0583	DNA-binding transcription factor activity
DR71_RS09490	COG1126	abc transporter atp-binding protein
DR71_RS09495	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DR71_RS09515	COG2271	Major facilitator Superfamily
DR71_RS09525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DR71_RS09540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DR71_RS09545	COG0406	alpha-ribazole phosphatase activity
DR71_RS09545	COG0494	nUDIX hydrolase
DR71_RS09550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DR71_RS09565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DR71_RS09585	COG4770	biotin carboxylase activity
DR71_RS09590	COG0742	ribosomal rna small subunit methyltransferase
DR71_RS09595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DR71_RS09610	COG0571	ribonuclease III activity
DR71_RS09620	COG1115	amino acid carrier protein
DR71_RS09630	COG1196	nuclear chromosome segregation
DR71_RS09665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DR71_RS09670	COG0336	Belongs to the RNA methyltransferase TrmD family
DR71_RS09675	COG0671	phosphoesterase, PA-phosphatase related
DR71_RS09700	COG0335	large ribosomal subunit rRNA binding
DR71_RS09705	COG0681	Belongs to the peptidase S26 family
DR71_RS09710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DR71_RS09720	COG0792	nuclease activity
DR71_RS09735	COG4974	Belongs to the 'phage' integrase family
DR71_RS09745	COG0052	Belongs to the universal ribosomal protein uS2 family
DR71_RS09755	COG0528	UMP kinase activity
DR71_RS09760	COG0233	cytoplasmic translational termination
DR71_RS09765	COG0575	Belongs to the CDS family
DR71_RS09775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DR71_RS09815	COG0579	oxidoreductase
DR71_RS09830	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DR71_RS09840	COG1648	precorrin-2 dehydrogenase activity
DR71_RS09840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DR71_RS09855	COG0442	prolyl-tRNA aminoacylation
DR71_RS09865	COG0779	Required for maturation of 30S ribosomal subunits
DR71_RS09880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DR71_RS09895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DR71_RS09920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DR71_RS09925	COG1185	polyribonucleotide nucleotidyltransferase activity
DR71_RS09930	COG2017	converts alpha-aldose to the beta-anomer
DR71_RS09950	COG2814	Major facilitator Superfamily
DR71_RS09955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DR71_RS09970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DR71_RS09980	COG1674	ftsk spoiiie
DR71_RS10000	COG1396	sequence-specific DNA binding
DR71_RS10005	COG1842	Phage shock protein A
DR71_RS10010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DR71_RS10015	COG1122	ATPase activity
DR71_RS10020	COG1268	BioY protein
DR71_RS10030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DR71_RS10035	COG2137	regulation of response to DNA damage stimulus
DR71_RS10040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DR71_RS10050	COG1196	nuclear chromosome segregation
DR71_RS10060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DR71_RS10085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DR71_RS10090	COG2233	PERMEase
DR71_RS10100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR71_RS10100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR71_RS10100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR71_RS10105	COG1105	Belongs to the carbohydrate kinase PfkB family
DR71_RS10110	COG1349	DNA-binding transcription factor activity
DR71_RS10115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DR71_RS10125	COG1643	Atp-dependent helicase
DR71_RS10130	COG1054	Belongs to the UPF0176 family
DR71_RS10135	COG4868	Belongs to the UPF0371 family
DR71_RS10155	COG0450	alkyl hydroperoxide reductase
DR71_RS10160	COG0583	DNA-binding transcription factor activity
DR71_RS10180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR71_RS10185	COG1321	iron dependent repressor
DR71_RS10200	COG2890	protein-(glutamine-N5) methyltransferase activity
DR71_RS10225	COG0471	metal ion transport
DR71_RS10245	COG0483	inositol monophosphate 1-phosphatase activity
DR71_RS10265	COG0756	dUTP diphosphatase activity
DR71_RS10295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DR71_RS10305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR71_RS10370	COG2837	iron assimilation
DR71_RS10385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DR71_RS10390	COG1560	Kdo2-lipid A biosynthetic process
DR71_RS10395	COG0438	transferase activity, transferring glycosyl groups
DR71_RS10405	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DR71_RS10410	COG1946	Acyl-CoA thioesterase
DR71_RS10415	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DR71_RS10420	COG0217	transcriptional regulatory protein
DR71_RS10430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DR71_RS10435	COG0632	four-way junction helicase activity
DR71_RS10450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR71_RS10455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR71_RS10465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DR71_RS10470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DR71_RS10480	COG0124	histidyl-tRNA synthetase
DR71_RS10490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DR71_RS10510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DR71_RS10530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DR71_RS10535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DR71_RS10540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DR71_RS10550	COG0006	proline dipeptidase activity
DR71_RS10555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DR71_RS10560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DR71_RS10570	COG0540	Belongs to the ATCase OTCase family
DR71_RS10575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DR71_RS10585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DR71_RS10590	COG0284	orotidine-5'-phosphate decarboxylase activity
DR71_RS10600	COG0194	GDP metabolic process
DR71_RS10605	COG1758	RNA polymerase activity
DR71_RS10615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DR71_RS10620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DR71_RS10625	COG0242	peptide deformylase activity
DR71_RS10630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DR71_RS10660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DR71_RS10670	COG0322	excinuclease ABC activity
DR71_RS10675	COG1660	Displays ATPase and GTPase activities
DR71_RS10685	COG1481	regulation of sporulation
DR71_RS10690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DR71_RS10695	COG0126	phosphoglycerate kinase activity
DR71_RS10705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DR71_RS10710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR71_RS10755	COG1316	TRANSCRIPTIONal
DR71_RS10785	COG0829	nickel cation binding