locus-tag	class	description
G7Y29_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7Y29_RS00010	COG0592	DNA-directed DNA polymerase activity
G7Y29_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G7Y29_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
G7Y29_RS00025	COG0187	DNA topoisomerase II activity
G7Y29_RS00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G7Y29_RS00100	COG1388	LysM domain
G7Y29_RS00105	COG1511	domain protein
G7Y29_RS00135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G7Y29_RS00155	COG0515	serine threonine protein kinase
G7Y29_RS00155	COG2815	serine threonine protein kinase
G7Y29_RS00160	COG0515	serine threonine protein kinase
G7Y29_RS00165	COG0768	penicillin binding
G7Y29_RS00180	COG1716	ATPase activity
G7Y29_RS00185	COG1716	ATPase activity
G7Y29_RS00185	COG1716	ATPase activity
G7Y29_RS00205	COG3226	Transcriptional regulator
G7Y29_RS00225	COG1482	cell wall glycoprotein biosynthetic process
G7Y29_RS00245	COG2066	Belongs to the glutaminase family
G7Y29_RS00265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7Y29_RS00285	COG1278	Cold shock
G7Y29_RS00300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7Y29_RS00305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G7Y29_RS00320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G7Y29_RS00350	COG0531	amino acid
G7Y29_RS00355	COG1643	Atp-dependent helicase
G7Y29_RS00390	COG2501	S4 domain
G7Y29_RS00410	COG3590	peptidase
G7Y29_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y29_RS00435	COG0277	FAD linked oxidase domain protein
G7Y29_RS00460	COG1216	Glycosyl transferase, family 2
G7Y29_RS00510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G7Y29_RS00515	COG0569	domain protein
G7Y29_RS00520	COG2239	Acts as a magnesium transporter
G7Y29_RS00530	COG0287	Prephenate dehydrogenase
G7Y29_RS00540	COG0590	tRNA wobble adenosine to inosine editing
G7Y29_RS00540	COG0037	tRNA processing
G7Y29_RS00555	COG2409	Drug exporters of the RND superfamily
G7Y29_RS00565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G7Y29_RS00615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7Y29_RS00640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G7Y29_RS00645	COG3442	glutamine amidotransferase
G7Y29_RS00650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7Y29_RS00660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7Y29_RS00665	COG0697	spore germination
G7Y29_RS00670	COG0527	aspartate kinase activity
G7Y29_RS00675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G7Y29_RS00710	COG0651	ATP synthesis coupled electron transport
G7Y29_RS00720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G7Y29_RS00720	COG2111	Na H antiporter
G7Y29_RS00750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7Y29_RS00770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7Y29_RS00775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7Y29_RS00790	COG0494	nUDIX hydrolase
G7Y29_RS00850	COG1205	dead DEAH box helicase
G7Y29_RS00850	COG1111	helicase
G7Y29_RS00865	COG1754	DNA topoisomerase type I activity
G7Y29_RS00865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G7Y29_RS00875	COG0470	DNA polymerase III
G7Y29_RS00890	COG0798	PFAM Bile acid sodium symporter
G7Y29_RS00895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G7Y29_RS00905	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y29_RS00920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7Y29_RS00940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G7Y29_RS00960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G7Y29_RS00960	COG5479	isomerase activity
G7Y29_RS01035	COG1088	dTDP-glucose 4,6-dehydratase activity
G7Y29_RS01060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7Y29_RS01070	COG1396	sequence-specific DNA binding
G7Y29_RS01070	COG3800	Transcriptional regulator
G7Y29_RS01080	COG1053	succinate dehydrogenase
G7Y29_RS01085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G7Y29_RS01095	COG2733	membrane
G7Y29_RS01110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G7Y29_RS01130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G7Y29_RS01135	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y29_RS01140	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y29_RS01155	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y29_RS01175	COG5002	protein histidine kinase activity
G7Y29_RS01180	COG0745	RESPONSE REGULATOR receiver
G7Y29_RS01200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G7Y29_RS01225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G7Y29_RS01230	COG0181	hydroxymethylbilane synthase activity
G7Y29_RS01235	COG1648	precorrin-2 dehydrogenase activity
G7Y29_RS01235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G7Y29_RS01255	COG2608	mercury ion transmembrane transporter activity
G7Y29_RS01255	COG2217	Heavy metal translocating P-type atpase
G7Y29_RS01260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G7Y29_RS01280	COG0406	alpha-ribazole phosphatase activity
G7Y29_RS01290	COG0785	Cytochrome C biogenesis protein
G7Y29_RS01295	COG1333	cytochrome c biogenesis protein
G7Y29_RS01300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7Y29_RS01330	COG3422	double-strand break repair
G7Y29_RS01365	COG4948	Mandelate Racemase Muconate Lactonizing
G7Y29_RS01370	COG0471	metal ion transport
G7Y29_RS01380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
G7Y29_RS01390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7Y29_RS01390	COG0438	transferase activity, transferring glycosyl groups
G7Y29_RS01405	COG0142	geranyltranstransferase activity
G7Y29_RS01430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G7Y29_RS01440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G7Y29_RS01465	COG1121	(ABC) transporter
G7Y29_RS01470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G7Y29_RS01480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G7Y29_RS01510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G7Y29_RS01515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G7Y29_RS01520	COG0049	tRNA binding
G7Y29_RS01525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7Y29_RS01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7Y29_RS01565	COG1302	Protein conserved in bacteria
G7Y29_RS01570	COG0051	transcription antitermination factor activity, RNA binding
G7Y29_RS01580	COG0088	Forms part of the polypeptide exit tunnel
G7Y29_RS01590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G7Y29_RS01595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G7Y29_RS01600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G7Y29_RS01610	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G7Y29_RS01620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G7Y29_RS01630	COG0351	phosphomethylpyrimidine kinase
G7Y29_RS01630	COG0352	thiamine-phosphate diphosphorylase activity
G7Y29_RS01630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G7Y29_RS01635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G7Y29_RS01650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G7Y29_RS01675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G7Y29_RS01690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G7Y29_RS01695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G7Y29_RS01700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G7Y29_RS01705	COG1841	ribosomal large subunit assembly
G7Y29_RS01710	COG0200	Binds to the 23S rRNA
G7Y29_RS01720	COG0201	protein transport
G7Y29_RS01725	COG0563	adenylate kinase activity
G7Y29_RS01735	COG1376	ErfK ybiS ycfS ynhG family protein
G7Y29_RS01745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G7Y29_RS01750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G7Y29_RS01760	COG0202	RNA polymerase activity
G7Y29_RS01770	COG0101	tRNA pseudouridine synthase activity
G7Y29_RS01790	COG1404	Belongs to the peptidase S8 family
G7Y29_RS01800	COG1674	ftsk spoiiie
G7Y29_RS01830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G7Y29_RS01835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G7Y29_RS01870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G7Y29_RS01875	COG0802	atpase or kinase
G7Y29_RS01890	COG0456	acetyltransferase
G7Y29_RS01900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G7Y29_RS01905	COG0459	protein refolding
G7Y29_RS01935	COG0516	GMP reductase activity
G7Y29_RS01940	COG0519	Catalyzes the synthesis of GMP from XMP
G7Y29_RS01940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G7Y29_RS01970	COG0747	negative chemotaxis
G7Y29_RS01975	COG0601	transmembrane transport
G7Y29_RS01980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7Y29_RS01995	COG2197	response regulator
G7Y29_RS02005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G7Y29_RS02020	COG2011	ABC-type metal ion transport system permease component
G7Y29_RS02030	COG1464	Belongs to the NlpA lipoprotein family
G7Y29_RS02035	COG1464	Belongs to the NlpA lipoprotein family
G7Y29_RS02040	COG0247	lactate metabolic process
G7Y29_RS02045	COG1139	Iron-sulfur cluster binding protein
G7Y29_RS02050	COG1556	Lactate utilization protein
G7Y29_RS02055	COG0587	DNA-directed DNA polymerase activity
G7Y29_RS02085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G7Y29_RS02090	COG2873	o-acetylhomoserine
G7Y29_RS02100	COG2838	Isocitrate dehydrogenase
G7Y29_RS02110	COG2860	membrane
G7Y29_RS02115	COG0180	Tryptophanyl-tRNA synthetase
G7Y29_RS02125	COG1686	Belongs to the peptidase S11 family
G7Y29_RS02135	COG2860	membrane
G7Y29_RS02160	COG1917	Cupin 2, conserved barrel domain protein
G7Y29_RS02160	COG1396	sequence-specific DNA binding
G7Y29_RS02165	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G7Y29_RS02165	COG1473	amidohydrolase
G7Y29_RS02175	COG1396	sequence-specific DNA binding
G7Y29_RS02175	COG3800	Transcriptional regulator
G7Y29_RS02180	COG2079	MmgE PrpD family protein
G7Y29_RS02185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G7Y29_RS02190	COG0372	Belongs to the citrate synthase family
G7Y29_RS02195	COG1473	amidohydrolase
G7Y29_RS02200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G7Y29_RS02210	COG4770	biotin carboxylase activity
G7Y29_RS02215	COG2897	thiosulfate sulfurtransferase activity
G7Y29_RS02240	COG0424	maF-like protein
G7Y29_RS02265	COG0753	catalase activity
G7Y29_RS02310	COG0515	serine threonine protein kinase
G7Y29_RS02360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G7Y29_RS02360	COG5479	isomerase activity
G7Y29_RS02405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G7Y29_RS02410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7Y29_RS02415	COG0736	holo-[acyl-carrier-protein] synthase activity
G7Y29_RS02470	COG1316	TRANSCRIPTIONal
G7Y29_RS02480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G7Y29_RS02520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G7Y29_RS02530	COG0745	RESPONSE REGULATOR receiver
G7Y29_RS02535	COG5002	protein histidine kinase activity
G7Y29_RS02535	COG5000	phosphorelay sensor kinase activity
G7Y29_RS02540	COG5401	PFAM Sporulation and spore germination
G7Y29_RS02550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G7Y29_RS02575	COG1162	GTPase activity
G7Y29_RS02580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G7Y29_RS02645	COG0513	Belongs to the DEAD box helicase family
G7Y29_RS02675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G7Y29_RS02700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7Y29_RS02745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G7Y29_RS02765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G7Y29_RS02770	COG2022	thiamine diphosphate biosynthetic process
G7Y29_RS02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7Y29_RS02780	COG2022	thiamine diphosphate biosynthetic process
G7Y29_RS02795	COG0352	thiamine-phosphate diphosphorylase activity
G7Y29_RS02800	COG2311	Membrane
G7Y29_RS02805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G7Y29_RS02815	COG0483	inositol monophosphate 1-phosphatase activity
G7Y29_RS02820	COG0483	inositol monophosphate 1-phosphatase activity
G7Y29_RS02835	COG2884	Cell division ATP-binding protein ftsE
G7Y29_RS02840	COG2177	Part of the ABC transporter FtsEX involved in
G7Y29_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y29_RS02920	COG1511	domain protein
G7Y29_RS02935	COG3634	alkyl hydroperoxide reductase activity
G7Y29_RS02940	COG1668	transmembrane transport
G7Y29_RS02945	COG4152	abc transporter atp-binding protein
G7Y29_RS02960	COG2391	methyltransferase activity
G7Y29_RS02965	COG1652	LysM domain
G7Y29_RS02970	COG1278	Cold shock
G7Y29_RS02995	COG2252	PERMEase
G7Y29_RS03000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7Y29_RS03020	COG0372	Belongs to the citrate synthase family
G7Y29_RS03025	COG0545	Peptidyl-prolyl cis-trans isomerase
G7Y29_RS03030	COG0656	L-ascorbic acid biosynthetic process
G7Y29_RS03040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7Y29_RS03045	COG3757	hydrolase, family 25
G7Y29_RS03050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G7Y29_RS03060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G7Y29_RS03065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G7Y29_RS03090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G7Y29_RS03100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G7Y29_RS03110	COG1201	RNA secondary structure unwinding
G7Y29_RS03120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G7Y29_RS03125	COG0586	Pfam SNARE associated Golgi protein
G7Y29_RS03145	COG1605	Chorismate mutase
G7Y29_RS03155	COG0739	heme binding
G7Y29_RS03200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G7Y29_RS03205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G7Y29_RS03225	COG0254	rRNA binding
G7Y29_RS03235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7Y29_RS03240	COG0521	Mo-molybdopterin cofactor biosynthetic process
G7Y29_RS03240	COG0315	cyclic pyranopterin monophosphate synthase activity
G7Y29_RS03265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G7Y29_RS03290	COG2818	Glycosylase
G7Y29_RS03305	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
G7Y29_RS03315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G7Y29_RS03340	COG0084	hydrolase, TatD family'
G7Y29_RS03345	COG3583	domain protein
G7Y29_RS03355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G7Y29_RS03365	COG0488	(ABC) transporter
G7Y29_RS03370	COG1914	H( )-stimulated, divalent metal cation uptake system
G7Y29_RS03375	COG4770	biotin carboxylase activity
G7Y29_RS03385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G7Y29_RS03395	COG2326	polyphosphate kinase activity
G7Y29_RS03400	COG2094	Belongs to the DNA glycosylase MPG family
G7Y29_RS03405	COG0561	phosphatase activity
G7Y29_RS03410	COG1024	Enoyl-CoA hydratase
G7Y29_RS03420	COG1063	alcohol dehydrogenase
G7Y29_RS03430	COG0438	transferase activity, transferring glycosyl groups
G7Y29_RS03440	COG3573	Dehydrogenase
G7Y29_RS03445	COG0471	metal ion transport
G7Y29_RS03450	COG3037	sugar-specific permease SgaT UlaA
G7Y29_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y29_RS03495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G7Y29_RS03500	COG0431	NADPH-dependent FMN reductase
G7Y29_RS03505	COG0193	aminoacyl-tRNA hydrolase activity
G7Y29_RS03515	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7Y29_RS03520	COG0193	aminoacyl-tRNA hydrolase activity
G7Y29_RS03525	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G7Y29_RS03530	COG0477	Major facilitator Superfamily
G7Y29_RS03535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G7Y29_RS03540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G7Y29_RS03550	COG1309	transcriptional regulator
G7Y29_RS03615	COG1174	glycine betaine transport
G7Y29_RS03620	COG1174	glycine betaine transport
G7Y29_RS03625	COG1125	glycine betaine transport
G7Y29_RS03625	COG0517	IMP dehydrogenase activity
G7Y29_RS03640	COG0415	Belongs to the DNA photolyase family
G7Y29_RS03665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G7Y29_RS03680	COG1072	(Pantothenic acid kinase))
G7Y29_RS03720	COG0114	fumarate hydratase activity
G7Y29_RS03725	COG1494	fructose-1,6-bisphosphatase
G7Y29_RS03735	COG1722	exodeoxyribonuclease VII activity
G7Y29_RS03740	COG1570	exodeoxyribonuclease VII activity
G7Y29_RS03755	COG1322	Protein conserved in bacteria
G7Y29_RS03765	COG0012	GTP binding
G7Y29_RS03820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G7Y29_RS03830	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G7Y29_RS03835	COG1793	dna ligase
G7Y29_RS03835	COG3285	dna ligase
G7Y29_RS03865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7Y29_RS03865	COG1116	anion transmembrane transporter activity
G7Y29_RS03870	COG4120	Belongs to the binding-protein-dependent transport system permease family
G7Y29_RS03895	COG4085	toxin activity
G7Y29_RS03895	COG1525	nuclease
G7Y29_RS03895	COG0737	Belongs to the 5'-nucleotidase family
G7Y29_RS03900	COG0259	pyridoxamine-phosphate oxidase activity
G7Y29_RS03905	COG0385	Bile acid
G7Y29_RS03920	COG0662	Cupin 2, conserved barrel domain protein
G7Y29_RS03930	COG2354	Protein conserved in bacteria
G7Y29_RS03940	COG4166	transmembrane transport
G7Y29_RS03945	COG0601	transmembrane transport
G7Y29_RS03960	COG4721	ABC-type cobalt transport system, permease component
G7Y29_RS03965	COG4172	Belongs to the ABC transporter superfamily
G7Y29_RS03975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G7Y29_RS03990	COG1217	gtp-binding protein TYPA
G7Y29_RS04030	COG1113	amino acid transport
G7Y29_RS04035	COG1113	amino acid transport
G7Y29_RS04045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7Y29_RS04050	COG1611	Belongs to the LOG family
G7Y29_RS04075	COG0297	glycogen (starch) synthase activity
G7Y29_RS04080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G7Y29_RS04090	COG1595	DNA-templated transcription, initiation
G7Y29_RS04105	COG0489	protein tyrosine kinase activity
G7Y29_RS04105	COG2151	metal-sulfur cluster biosynthetic enzyme
G7Y29_RS04120	COG0567	Dehydrogenase, E1 component
G7Y29_RS04120	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7Y29_RS04125	COG1132	(ABC) transporter
G7Y29_RS04135	COG2272	Belongs to the type-B carboxylesterase lipase family
G7Y29_RS04150	COG2814	Major facilitator Superfamily
G7Y29_RS04160	COG0039	L-malate dehydrogenase activity
G7Y29_RS04190	COG0494	nUDIX hydrolase
G7Y29_RS04215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G7Y29_RS04235	COG2353	YceI-like domain
G7Y29_RS04245	COG1983	PspC domain protein
G7Y29_RS04250	COG0657	acetylesterase activity
G7Y29_RS04270	COG0019	diaminopimelate decarboxylase activity
G7Y29_RS04275	COG0460	homoserine dehydrogenase
G7Y29_RS04280	COG0083	homoserine kinase activity
G7Y29_RS04310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7Y29_RS04320	COG0356	it plays a direct role in the translocation of protons across the membrane
G7Y29_RS04325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7Y29_RS04330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G7Y29_RS04335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7Y29_RS04340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G7Y29_RS04350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G7Y29_RS04365	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
G7Y29_RS04385	COG0366	Alpha amylase catalytic
G7Y29_RS04390	COG1119	ATPase activity
G7Y29_RS04405	COG0477	Major facilitator Superfamily
G7Y29_RS04410	COG1957	nucleoside hydrolase
G7Y29_RS04425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G7Y29_RS04435	COG0482	sulfurtransferase activity
G7Y29_RS04450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G7Y29_RS04480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7Y29_RS04485	COG0154	amidase activity
G7Y29_RS04495	COG0205	6-phosphofructokinase activity
G7Y29_RS04515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7Y29_RS04520	COG3949	Membrane
G7Y29_RS04530	COG0435	Glutathione S-transferase
G7Y29_RS04555	COG0668	transmembrane transport
G7Y29_RS04560	COG0028	Belongs to the TPP enzyme family
G7Y29_RS04565	COG0440	acetolactate synthase activity
G7Y29_RS04570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G7Y29_RS04635	COG1966	Carbon starvation protein
G7Y29_RS04665	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7Y29_RS04690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G7Y29_RS04720	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7Y29_RS04740	COG2801	Transposase and inactivated derivatives
G7Y29_RS04745	COG3586	endonuclease activity
G7Y29_RS04805	COG0019	diaminopimelate decarboxylase activity
G7Y29_RS04815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G7Y29_RS04820	COG0066	3-isopropylmalate dehydratase activity
G7Y29_RS04835	COG0406	alpha-ribazole phosphatase activity
G7Y29_RS04835	COG0494	nUDIX hydrolase
G7Y29_RS04840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G7Y29_RS04855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G7Y29_RS04860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G7Y29_RS04875	COG0742	ribosomal rna small subunit methyltransferase
G7Y29_RS04880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G7Y29_RS04890	COG4598	ABC transporter
G7Y29_RS04895	COG0765	amino acid transport
G7Y29_RS04900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7Y29_RS04910	COG1272	protein, Hemolysin III
G7Y29_RS04940	COG2226	methyltransferase
G7Y29_RS04945	COG0539	negative regulation of cytoplasmic translation
G7Y29_RS04950	COG0237	dephospho-CoA kinase activity
G7Y29_RS04975	COG3973	AAA domain
G7Y29_RS04985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7Y29_RS05010	COG2197	response regulator
G7Y29_RS05025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G7Y29_RS05035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G7Y29_RS05050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7Y29_RS05050	COG0072	phenylalanine-tRNA ligase activity
G7Y29_RS05055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G7Y29_RS05060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G7Y29_RS05070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G7Y29_RS05075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G7Y29_RS05080	COG1438	arginine binding
G7Y29_RS05085	COG0137	argininosuccinate synthase activity
G7Y29_RS05090	COG0165	Argininosuccinate lyase
G7Y29_RS05095	COG2835	tetraacyldisaccharide 4'-kinase activity
G7Y29_RS05100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G7Y29_RS05125	COG0647	UMP catabolic process
G7Y29_RS05135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G7Y29_RS05140	COG0497	DNA recombination
G7Y29_RS05155	COG0494	nUDIX hydrolase
G7Y29_RS05160	COG4974	Belongs to the 'phage' integrase family
G7Y29_RS05180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G7Y29_RS05190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G7Y29_RS05195	COG1160	GTP binding
G7Y29_RS05245	COG0653	protein targeting
G7Y29_RS05250	COG1716	ATPase activity
G7Y29_RS05280	COG1253	flavin adenine dinucleotide binding
G7Y29_RS05285	COG0513	Belongs to the DEAD box helicase family
G7Y29_RS05290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G7Y29_RS05300	COG0598	Magnesium transport protein CorA
G7Y29_RS05305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G7Y29_RS05315	COG1882	Formate acetyltransferase
G7Y29_RS05320	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7Y29_RS05340	COG0463	Glycosyl transferase, family 2
G7Y29_RS05395	COG2378	regulation of single-species biofilm formation
G7Y29_RS05400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G7Y29_RS05420	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G7Y29_RS05425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7Y29_RS05435	COG1222	aaa ATPase
G7Y29_RS05445	COG1362	aminopeptidase activity
G7Y29_RS05460	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G7Y29_RS05465	COG1027	Aspartate ammonia-lyase
G7Y29_RS05470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G7Y29_RS05480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7Y29_RS05490	COG0215	cysteine-tRNA ligase activity
G7Y29_RS05495	COG1968	undecaprenyl-diphosphatase activity
G7Y29_RS05555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G7Y29_RS05560	COG3883	PFAM NLP P60 protein
G7Y29_RS05560	COG0791	NLP P60 protein
G7Y29_RS05570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G7Y29_RS05585	COG3830	Belongs to the UPF0237 family
G7Y29_RS05590	COG2848	UPF0210 protein
G7Y29_RS05605	COG0488	(ABC) transporter
G7Y29_RS05615	COG0822	iron-sulfur transferase activity
G7Y29_RS05625	COG0396	ATPase activity
G7Y29_RS05660	COG1612	heme a metabolic process
G7Y29_RS05680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G7Y29_RS05695	COG0363	glucosamine-6-phosphate deaminase activity
G7Y29_RS05700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G7Y29_RS05710	COG0126	phosphoglycerate kinase activity
G7Y29_RS05715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G7Y29_RS05720	COG1481	regulation of sporulation
G7Y29_RS05725	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G7Y29_RS05730	COG1660	Displays ATPase and GTPase activities
G7Y29_RS05735	COG0322	excinuclease ABC activity
G7Y29_RS05780	COG0242	peptide deformylase activity
G7Y29_RS05785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G7Y29_RS05790	COG2514	catechol 2,3-dioxygenase activity
G7Y29_RS05805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G7Y29_RS05820	COG0194	GDP metabolic process
G7Y29_RS05830	COG0284	orotidine-5'-phosphate decarboxylase activity
G7Y29_RS05835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G7Y29_RS05845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G7Y29_RS05855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G7Y29_RS05890	COG2326	polyphosphate kinase activity
G7Y29_RS05895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7Y29_RS05900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G7Y29_RS05905	COG0006	proline dipeptidase activity
G7Y29_RS05920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7Y29_RS05925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G7Y29_RS05935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7Y29_RS05945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G7Y29_RS05965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G7Y29_RS05985	COG0431	NADPH-dependent FMN reductase
G7Y29_RS05990	COG1760	l-serine dehydratase
G7Y29_RS05995	COG0124	histidyl-tRNA synthetase
G7Y29_RS06005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G7Y29_RS06020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7Y29_RS06040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7Y29_RS06045	COG1862	Preprotein translocase
G7Y29_RS06050	COG2255	four-way junction helicase activity
G7Y29_RS06055	COG0632	four-way junction helicase activity
G7Y29_RS06060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G7Y29_RS06070	COG1946	Acyl-CoA thioesterase
G7Y29_RS06080	COG0438	transferase activity, transferring glycosyl groups
G7Y29_RS06085	COG1560	Kdo2-lipid A biosynthetic process
G7Y29_RS06090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G7Y29_RS06100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G7Y29_RS06175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7Y29_RS06190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G7Y29_RS06200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7Y29_RS06210	COG0756	dUTP diphosphatase activity
G7Y29_RS06260	COG2264	protein methyltransferase activity
G7Y29_RS06275	COG1321	iron dependent repressor
G7Y29_RS06280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G7Y29_RS06305	COG1643	Atp-dependent helicase
G7Y29_RS06310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7Y29_RS06320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G7Y29_RS06325	COG1349	DNA-binding transcription factor activity
G7Y29_RS06335	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
G7Y29_RS06335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7Y29_RS06335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7Y29_RS06340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y29_RS06345	COG2233	PERMEase
G7Y29_RS06350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G7Y29_RS06365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G7Y29_RS06390	COG1196	nuclear chromosome segregation
G7Y29_RS06440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G7Y29_RS06450	COG2801	Transposase and inactivated derivatives
G7Y29_RS06520	COG1126	abc transporter atp-binding protein
G7Y29_RS06525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7Y29_RS06530	COG0765	amino acid transport
G7Y29_RS06535	COG0765	amino acid transport
G7Y29_RS06540	COG2137	regulation of response to DNA damage stimulus
G7Y29_RS06555	COG1268	BioY protein
G7Y29_RS06560	COG1122	ATPase activity
G7Y29_RS06565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G7Y29_RS06570	COG1842	Phage shock protein A
G7Y29_RS06575	COG1396	sequence-specific DNA binding
G7Y29_RS06580	COG1058	Belongs to the CinA family
G7Y29_RS06580	COG1546	Belongs to the CinA family
G7Y29_RS06595	COG1674	ftsk spoiiie
G7Y29_RS06605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G7Y29_RS06610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7Y29_RS06615	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
G7Y29_RS06630	COG1185	polyribonucleotide nucleotidyltransferase activity
G7Y29_RS06635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G7Y29_RS06640	COG1957	nucleoside hydrolase
G7Y29_RS06650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G7Y29_RS06655	COG2977	Belongs to the P-Pant transferase superfamily
G7Y29_RS06660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G7Y29_RS06670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G7Y29_RS06675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G7Y29_RS06680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G7Y29_RS06695	COG0779	Required for maturation of 30S ribosomal subunits
G7Y29_RS06705	COG2409	Drug exporters of the RND superfamily
G7Y29_RS06715	COG0442	prolyl-tRNA aminoacylation
G7Y29_RS06720	COG3022	response to hydroperoxide
G7Y29_RS06740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G7Y29_RS06740	COG1648	precorrin-2 dehydrogenase activity
G7Y29_RS06745	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G7Y29_RS06750	COG0579	oxidoreductase
G7Y29_RS06785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G7Y29_RS06790	COG0750	zinc metalloprotease
G7Y29_RS06795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G7Y29_RS06805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G7Y29_RS06825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G7Y29_RS06825	COG2755	lipolytic protein G-D-S-L family
G7Y29_RS06850	COG4974	Belongs to the 'phage' integrase family
G7Y29_RS06865	COG0792	nuclease activity
G7Y29_RS06880	COG0681	Belongs to the peptidase S26 family
G7Y29_RS06885	COG0335	large ribosomal subunit rRNA binding
G7Y29_RS06895	COG0336	Belongs to the RNA methyltransferase TrmD family
G7Y29_RS06900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G7Y29_RS06905	COG0228	four-way junction DNA binding
G7Y29_RS06945	COG1254	Belongs to the acylphosphatase family
G7Y29_RS06950	COG1115	amino acid carrier protein
G7Y29_RS06955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G7Y29_RS06960	COG0571	ribonuclease III activity
G7Y29_RS06975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G7Y29_RS06980	COG1929	Belongs to the glycerate kinase type-1 family
G7Y29_RS07000	COG0058	SHG alpha-glucan phosphorylase activity
G7Y29_RS07005	COG0590	tRNA wobble adenosine to inosine editing
G7Y29_RS07010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G7Y29_RS07010	COG0512	Glutamine amidotransferase of anthranilate synthase
G7Y29_RS07020	COG0469	pyruvate kinase activity
G7Y29_RS07025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G7Y29_RS07040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G7Y29_RS07045	COG0107	imidazoleglycerol-phosphate synthase activity
G7Y29_RS07055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G7Y29_RS07060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G7Y29_RS07075	COG0131	Imidazoleglycerol-phosphate dehydratase
G7Y29_RS07085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G7Y29_RS07105	COG1309	transcriptional regulator
G7Y29_RS07145	COG1739	Uncharacterized protein family UPF0029
G7Y29_RS07155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7Y29_RS07180	COG0577	efflux transmembrane transporter activity
G7Y29_RS07185	COG1136	(ABC) transporter
G7Y29_RS07205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G7Y29_RS07215	COG0488	(ABC) transporter
G7Y29_RS07225	COG0252	asparaginase activity
G7Y29_RS07240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G7Y29_RS07245	COG3599	regulation of cell shape
G7Y29_RS07255	COG1799	cell septum assembly
G7Y29_RS07260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G7Y29_RS07265	COG1496	oxidoreductase activity
G7Y29_RS07270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G7Y29_RS07275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G7Y29_RS07280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7Y29_RS07285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7Y29_RS07300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7Y29_RS07310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7Y29_RS07315	COG0768	penicillin binding
G7Y29_RS07325	COG0275	rRNA processing
G7Y29_RS07350	COG0142	geranyltranstransferase activity
G7Y29_RS07370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G7Y29_RS07390	COG1940	carbohydrate kinase activity
G7Y29_RS07395	COG0438	transferase activity, transferring glycosyl groups
G7Y29_RS07405	COG0791	NLP P60 protein
G7Y29_RS07410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G7Y29_RS07415	COG0723	plastoquinol--plastocyanin reductase activity
G7Y29_RS07420	COG2010	Cytochrome c
G7Y29_RS07435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G7Y29_RS07455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G7Y29_RS07460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G7Y29_RS07475	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7Y29_RS07480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7Y29_RS07480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7Y29_RS07485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G7Y29_RS07490	COG0509	glycine decarboxylation via glycine cleavage system
G7Y29_RS07495	COG0321	lipoyl(octanoyl) transferase activity
G7Y29_RS07505	COG1960	acyl-CoA dehydrogenase activity
G7Y29_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y29_RS07520	COG2030	dehydratase
G7Y29_RS07535	COG0174	glutamine synthetase
G7Y29_RS07560	COG1051	belongs to the nudix hydrolase family
G7Y29_RS07575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G7Y29_RS07590	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G7Y29_RS07595	COG0174	glutamine synthetase
G7Y29_RS07615	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
G7Y29_RS07645	COG0546	phosphoglycolate phosphatase activity
G7Y29_RS07675	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G7Y29_RS07690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7Y29_RS07700	COG1012	belongs to the aldehyde dehydrogenase family
G7Y29_RS07715	COG2860	membrane
G7Y29_RS07735	COG2860	membrane
G7Y29_RS07750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G7Y29_RS07820	COG1134	teichoic acid transport
G7Y29_RS07860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G7Y29_RS07870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G7Y29_RS07915	COG3956	TIGRFAM MazG family protein
G7Y29_RS07925	COG0358	DNA primase activity
G7Y29_RS07940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G7Y29_RS07960	COG0423	glycine-tRNA ligase activity
G7Y29_RS07975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G7Y29_RS07980	COG1381	Involved in DNA repair and RecF pathway recombination
G7Y29_RS08005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G7Y29_RS08025	COG1420	regulation of RNA biosynthetic process
G7Y29_RS08040	COG1022	Amp-dependent synthetase and ligase
G7Y29_RS08055	COG0339	signal peptide processing
G7Y29_RS08060	COG2272	Belongs to the type-B carboxylesterase lipase family
G7Y29_RS08070	COG1132	(ABC) transporter
G7Y29_RS08080	COG0366	Alpha amylase catalytic
G7Y29_RS08090	COG1114	Component of the transport system for branched-chain amino acids
G7Y29_RS08095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7Y29_RS08105	COG0601	transmembrane transport
G7Y29_RS08110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7Y29_RS08140	COG0481	GTPase activity
G7Y29_RS08150	COG0268	Binds directly to 16S ribosomal RNA
G7Y29_RS08155	COG1280	lysine exporter protein (LysE YggA)
G7Y29_RS08175	COG1596	polysaccharide export
G7Y29_RS08175	COG1555	photosystem II stabilization
G7Y29_RS08180	COG1307	EDD domain protein, DegV family
G7Y29_RS08185	COG0406	alpha-ribazole phosphatase activity
G7Y29_RS08195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G7Y29_RS08205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G7Y29_RS08215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G7Y29_RS08225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G7Y29_RS08235	COG1530	ribonuclease E activity
G7Y29_RS08245	COG0105	UTP biosynthetic process
G7Y29_RS08260	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y29_RS08270	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7Y29_RS08270	COG1024	Enoyl-CoA hydratase
G7Y29_RS08275	COG0183	Belongs to the thiolase family
G7Y29_RS08285	COG0285	dihydrofolate synthase activity
G7Y29_RS08290	COG0525	valine-tRNA ligase activity
G7Y29_RS08295	COG0039	L-malate dehydrogenase activity
G7Y29_RS08305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G7Y29_RS08315	COG0740	serine-type endopeptidase activity
G7Y29_RS08330	COG0544	peptidyl-prolyl cis-trans isomerase activity
G7Y29_RS08355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G7Y29_RS08375	COG2837	iron assimilation
G7Y29_RS08405	COG1215	transferase activity, transferring glycosyl groups
G7Y29_RS08410	COG0698	ribose 5-phosphate isomerase
G7Y29_RS08415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G7Y29_RS08425	COG2188	Transcriptional regulator
G7Y29_RS08435	COG0668	transmembrane transport
G7Y29_RS08485	COG0477	Major facilitator Superfamily
G7Y29_RS08500	COG1024	Enoyl-CoA hydratase
G7Y29_RS08505	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7Y29_RS08505	COG1902	pentaerythritol trinitrate reductase activity
G7Y29_RS08525	COG3655	Transcriptional regulator
G7Y29_RS08535	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G7Y29_RS08550	COG1376	ErfK ybiS ycfS ynhG family protein
G7Y29_RS08560	COG1335	isochorismatase
G7Y29_RS08595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G7Y29_RS08595	COG2308	Evidence 4 Homologs of previously reported genes of
G7Y29_RS08620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G7Y29_RS08625	COG1234	tRNA 3'-trailer cleavage
G7Y29_RS08630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G7Y29_RS08640	COG3191	aminopeptidase activity
G7Y29_RS08655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G7Y29_RS08660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G7Y29_RS08680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G7Y29_RS08685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7Y29_RS08695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7Y29_RS08710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G7Y29_RS08715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G7Y29_RS08725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G7Y29_RS08750	COG0033	Phosphoglucomutase
G7Y29_RS08755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G7Y29_RS08760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G7Y29_RS08765	COG4591	ABC-type transport system involved in lipoprotein release permease component
G7Y29_RS08770	COG0577	efflux transmembrane transporter activity
G7Y29_RS08770	COG1136	(ABC) transporter
G7Y29_RS08790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7Y29_RS08795	COG2197	response regulator
G7Y29_RS08805	COG1045	serine acetyltransferase
G7Y29_RS08835	COG1937	Protein conserved in bacteria
G7Y29_RS08870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G7Y29_RS08890	COG0456	acetyltransferase
G7Y29_RS08905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G7Y29_RS08920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G7Y29_RS08945	COG0047	phosphoribosylformylglycinamidine synthase activity
G7Y29_RS08950	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G7Y29_RS08980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G7Y29_RS08990	COG0151	Belongs to the GarS family
G7Y29_RS08995	COG0537	adenosine 5'-monophosphoramidase activity
G7Y29_RS09005	COG2205	protein histidine kinase activity
G7Y29_RS09010	COG0745	RESPONSE REGULATOR receiver
G7Y29_RS09015	COG0477	Major facilitator Superfamily
G7Y29_RS09035	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G7Y29_RS09050	COG1609	Transcriptional regulator
G7Y29_RS09060	COG1120	ATPase activity
G7Y29_RS09065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G7Y29_RS09075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7Y29_RS09080	COG0215	cysteine-tRNA ligase activity
G7Y29_RS09085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7Y29_RS09090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G7Y29_RS09100	COG2847	Copper chaperone PCu(A)C
G7Y29_RS09105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G7Y29_RS09110	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
G7Y29_RS09120	COG0288	reversible hydration of carbon dioxide
G7Y29_RS09125	COG1194	a g-specific adenine glycosylase
G7Y29_RS09135	COG0428	transporter
G7Y29_RS09145	COG0542	response to heat
G7Y29_RS09150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7Y29_RS09165	COG3711	transcriptional antiterminator
G7Y29_RS09175	COG2314	TM2 domain
G7Y29_RS09180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G7Y29_RS09190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G7Y29_RS09215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G7Y29_RS09225	COG0302	gtp cyclohydrolase
G7Y29_RS09230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7Y29_RS09240	COG0037	tRNA processing
G7Y29_RS09245	COG2027	D-alanyl-D-alanine carboxypeptidase
G7Y29_RS09250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G7Y29_RS09265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7Y29_RS09305	COG2326	polyphosphate kinase activity
G7Y29_RS09335	COG1297	OPT oligopeptide transporter protein
G7Y29_RS09350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G7Y29_RS09350	COG2111	Na H antiporter
G7Y29_RS09355	COG1006	Multisubunit Na H antiporter MnhC subunit
G7Y29_RS09360	COG0651	ATP synthesis coupled electron transport
G7Y29_RS09370	COG2212	antiporter activity
G7Y29_RS09380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G7Y29_RS09400	COG0242	peptide deformylase activity
G7Y29_RS09415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7Y29_RS09425	COG1131	(ABC) transporter
G7Y29_RS09440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7Y29_RS09445	COG0515	serine threonine protein kinase
G7Y29_RS09450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G7Y29_RS09455	COG0280	phosphate acetyltransferase
G7Y29_RS09475	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
G7Y29_RS09490	COG4129	membrane
G7Y29_RS09495	COG0191	fructose-bisphosphate aldolase activity
G7Y29_RS09520	COG2897	thiosulfate sulfurtransferase activity
G7Y29_RS09530	COG0542	response to heat
G7Y29_RS09560	COG0028	Belongs to the TPP enzyme family
G7Y29_RS09570	COG0789	Transcriptional regulator
G7Y29_RS09580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G7Y29_RS09585	COG0443	Heat shock 70 kDa protein
G7Y29_RS09590	COG1012	belongs to the aldehyde dehydrogenase family
G7Y29_RS09605	COG0693	protein deglycase activity
G7Y29_RS09620	COG0095	Lipoate-protein ligase
G7Y29_RS09625	COG0730	response to heat
G7Y29_RS09655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G7Y29_RS09660	COG0493	'glutamate synthase
G7Y29_RS09685	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7Y29_RS09710	COG1518	maintenance of DNA repeat elements
G7Y29_RS09745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G7Y29_RS09760	COG2814	Major facilitator Superfamily
G7Y29_RS09775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G7Y29_RS09780	COG3119	arylsulfatase activity
G7Y29_RS09790	COG1472	Belongs to the glycosyl hydrolase 3 family
G7Y29_RS09800	COG4981	capsule polysaccharide biosynthetic process
G7Y29_RS09825	COG0438	transferase activity, transferring glycosyl groups
G7Y29_RS09835	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G7Y29_RS09840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G7Y29_RS09865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7Y29_RS09870	COG3321	synthase
G7Y29_RS09870	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G7Y29_RS09870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7Y29_RS09875	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y29_RS09880	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G7Y29_RS09890	COG5479	isomerase activity
G7Y29_RS09890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G7Y29_RS09905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G7Y29_RS09910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G7Y29_RS09915	COG0671	phosphoesterase, PA-phosphatase related
G7Y29_RS09920	COG1216	Glycosyl transferase, family 2
G7Y29_RS09960	COG3546	catalase activity
G7Y29_RS10005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7Y29_RS10010	COG0561	phosphatase activity
G7Y29_RS10020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G7Y29_RS10025	COG2188	Transcriptional regulator
G7Y29_RS10045	COG0077	Prephenate dehydratase
G7Y29_RS10055	COG1316	TRANSCRIPTIONal
G7Y29_RS10065	COG1115	amino acid carrier protein
G7Y29_RS10070	COG0010	Belongs to the arginase family
G7Y29_RS10075	COG1113	amino acid transport
G7Y29_RS10100	COG2986	histidine ammonia-lyase
G7Y29_RS10105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G7Y29_RS10110	COG1228	amidohydrolase
G7Y29_RS10135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7Y29_RS10145	COG2814	Major facilitator Superfamily
G7Y29_RS10160	COG2197	response regulator
G7Y29_RS10165	COG4585	Histidine kinase
G7Y29_RS10180	COG2755	lipolytic protein G-D-S-L family
G7Y29_RS10195	COG0706	membrane insertase activity
G7Y29_RS10220	COG0564	pseudouridine synthase activity
G7Y29_RS10250	COG2186	Transcriptional regulator
G7Y29_RS10260	COG1842	Phage shock protein A
G7Y29_RS10265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7Y29_RS10280	COG0477	Major facilitator Superfamily
G7Y29_RS10290	COG0305	Participates in initiation and elongation during chromosome replication
G7Y29_RS10315	COG0359	binds to the 23S rRNA
G7Y29_RS10320	COG0629	single-stranded DNA binding
G7Y29_RS10340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7Y29_RS10365	COG1054	Belongs to the UPF0176 family
G7Y29_RS10375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G7Y29_RS10380	COG2224	Isocitrate lyase
G7Y29_RS10385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7Y29_RS10395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G7Y29_RS10395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G7Y29_RS10425	COG2197	response regulator
G7Y29_RS10430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y29_RS10435	COG2814	Major facilitator Superfamily
G7Y29_RS10455	COG2149	membrane
G7Y29_RS10465	COG0604	alcohol dehydrogenase
G7Y29_RS10475	COG0495	leucyl-tRNA aminoacylation
G7Y29_RS10505	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7Y29_RS10525	COG3842	ATPase activity
G7Y29_RS10540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G7Y29_RS10545	COG0512	Glutamine amidotransferase of anthranilate synthase
G7Y29_RS10555	COG0135	phosphoribosylanthranilate isomerase activity
G7Y29_RS10555	COG0134	indole-3-glycerol-phosphate synthase activity
G7Y29_RS10565	COG0159	tryptophan synthase activity
G7Y29_RS10585	COG1678	Uncharacterized ACR, COG1678
G7Y29_RS10590	COG0617	tRNA 3'-terminal CCA addition
G7Y29_RS10610	COG1595	DNA-templated transcription, initiation
G7Y29_RS10620	COG3118	belongs to the thioredoxin family
G7Y29_RS10625	COG3409	Peptidoglycan-binding domain 1 protein
G7Y29_RS10625	COG0860	N-Acetylmuramoyl-L-alanine amidase
G7Y29_RS10640	COG1192	Involved in chromosome partitioning
G7Y29_RS10645	COG0357	Ribosomal RNA small subunit methyltransferase G
G7Y29_RS10655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G7Y29_RS10665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G7Y29_RS10670	COG1192	Involved in chromosome partitioning
G7Y29_RS10700	COG1136	(ABC) transporter
G7Y29_RS10710	COG2197	response regulator
G7Y29_RS10745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD