locus-tag	class	description
BBR43_RS00020	COG0740	serine-type endopeptidase activity
BBR43_RS00025	COG3104	oligopeptide transport
BBR43_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
BBR43_RS00035	COG2814	Major facilitator Superfamily
BBR43_RS00040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BBR43_RS00065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BBR43_RS00070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BBR43_RS00080	COG0285	dihydrofolate synthase activity
BBR43_RS00100	COG0798	PFAM Bile acid sodium symporter
BBR43_RS00110	COG0105	UTP biosynthetic process
BBR43_RS00120	COG1530	ribonuclease E activity
BBR43_RS00125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BBR43_RS00130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BBR43_RS00165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBR43_RS00180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BBR43_RS00190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBR43_RS00195	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BBR43_RS00205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBR43_RS00215	COG0406	alpha-ribazole phosphatase activity
BBR43_RS00220	COG1307	EDD domain protein, DegV family
BBR43_RS00250	COG3961	Belongs to the TPP enzyme family
BBR43_RS00265	COG0268	Binds directly to 16S ribosomal RNA
BBR43_RS00275	COG0481	GTPase activity
BBR43_RS00290	COG1473	amidohydrolase
BBR43_RS00300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBR43_RS00310	COG4172	Belongs to the ABC transporter superfamily
BBR43_RS00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBR43_RS00320	COG0601	transmembrane transport
BBR43_RS00325	COG0747	negative chemotaxis
BBR43_RS00330	COG2188	Transcriptional regulator
BBR43_RS00335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBR43_RS00340	COG1114	Component of the transport system for branched-chain amino acids
BBR43_RS00350	COG1132	(ABC) transporter
BBR43_RS00360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BBR43_RS00395	COG1518	maintenance of DNA repeat elements
BBR43_RS00405	COG2272	Belongs to the type-B carboxylesterase lipase family
BBR43_RS00420	COG1022	Amp-dependent synthetase and ligase
BBR43_RS00435	COG1253	flavin adenine dinucleotide binding
BBR43_RS00450	COG1420	regulation of RNA biosynthetic process
BBR43_RS00455	COG0484	heat shock protein binding
BBR43_RS00470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BBR43_RS00480	COG0789	Transcriptional regulator
BBR43_RS00500	COG1381	Involved in DNA repair and RecF pathway recombination
BBR43_RS00505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BBR43_RS00520	COG0423	glycine-tRNA ligase activity
BBR43_RS00575	COG0358	DNA primase activity
BBR43_RS00610	COG4988	ABC transporter
BBR43_RS00660	COG2390	Transcriptional regulator
BBR43_RS00665	COG0813	purine-nucleoside phosphorylase activity
BBR43_RS00680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBR43_RS00685	COG2860	membrane
BBR43_RS00690	COG0668	transmembrane transport
BBR43_RS00715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBR43_RS00720	COG2267	carboxylic ester hydrolase activity
BBR43_RS00725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BBR43_RS00755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBR43_RS00775	COG0557	exoribonuclease II activity
BBR43_RS00800	COG0174	glutamine synthetase
BBR43_RS00805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BBR43_RS00825	COG1129	ABC transporter
BBR43_RS00835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BBR43_RS00910	COG2963	transposase activity
BBR43_RS00915	COG2801	Transposase and inactivated derivatives
BBR43_RS00955	COG1484	DNA-dependent DNA replication
BBR43_RS00960	COG4584	PFAM Integrase catalytic
BBR43_RS00995	COG0174	glutamine synthetase
BBR43_RS01010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BBR43_RS01015	COG0321	lipoyl(octanoyl) transferase activity
BBR43_RS01020	COG0509	glycine decarboxylation via glycine cleavage system
BBR43_RS01025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BBR43_RS01030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBR43_RS01030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBR43_RS01035	COG2814	Major facilitator Superfamily
BBR43_RS01040	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBR43_RS01060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBR43_RS01065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BBR43_RS01125	COG0438	transferase activity, transferring glycosyl groups
BBR43_RS01130	COG1940	carbohydrate kinase activity
BBR43_RS01150	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BBR43_RS01170	COG0142	geranyltranstransferase activity
BBR43_RS01195	COG0275	rRNA processing
BBR43_RS01205	COG0768	penicillin binding
BBR43_RS01210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBR43_RS01220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBR43_RS01235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BBR43_RS01240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBR43_RS01245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BBR43_RS01250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBR43_RS01255	COG1496	oxidoreductase activity
BBR43_RS01260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBR43_RS01265	COG1799	cell septum assembly
BBR43_RS01275	COG3599	regulation of cell shape
BBR43_RS01285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BBR43_RS01305	COG0252	asparaginase activity
BBR43_RS01320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BBR43_RS01365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBR43_RS01370	COG1739	Uncharacterized protein family UPF0029
BBR43_RS01395	COG2176	DNA-directed DNA polymerase activity
BBR43_RS01425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BBR43_RS01430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBR43_RS01445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BBR43_RS01455	COG0483	inositol monophosphate 1-phosphatase activity
BBR43_RS01460	COG0107	imidazoleglycerol-phosphate synthase activity
BBR43_RS01480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BBR43_RS01485	COG0469	pyruvate kinase activity
BBR43_RS01495	COG0058	SHG alpha-glucan phosphorylase activity
BBR43_RS01510	COG1929	Belongs to the glycerate kinase type-1 family
BBR43_RS01515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBR43_RS01535	COG0571	ribonuclease III activity
BBR43_RS01540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBR43_RS01545	COG1115	amino acid carrier protein
BBR43_RS01550	COG1254	Belongs to the acylphosphatase family
BBR43_RS01555	COG1196	nuclear chromosome segregation
BBR43_RS01565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBR43_RS01565	COG2111	Na H antiporter
BBR43_RS01570	COG1006	Multisubunit Na H antiporter MnhC subunit
BBR43_RS01575	COG0651	ATP synthesis coupled electron transport
BBR43_RS01605	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBR43_RS01615	COG0535	radical SAM domain protein
BBR43_RS01620	COG2755	lipolytic protein G-D-S-L family
BBR43_RS01620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBR43_RS01625	COG0228	four-way junction DNA binding
BBR43_RS01640	COG0336	Belongs to the RNA methyltransferase TrmD family
BBR43_RS01665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BBR43_RS01670	COG2022	thiamine diphosphate biosynthetic process
BBR43_RS01685	COG0352	thiamine-phosphate diphosphorylase activity
BBR43_RS01695	COG0335	large ribosomal subunit rRNA binding
BBR43_RS01700	COG0681	Belongs to the peptidase S26 family
BBR43_RS01710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBR43_RS01720	COG0792	nuclease activity
BBR43_RS01735	COG4974	Belongs to the 'phage' integrase family
BBR43_RS01750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BBR43_RS01760	COG0233	cytoplasmic translational termination
BBR43_RS01765	COG0575	Belongs to the CDS family
BBR43_RS01775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BBR43_RS01785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BBR43_RS01795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BBR43_RS01800	COG0768	penicillin binding
BBR43_RS01820	COG0579	oxidoreductase
BBR43_RS01825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BBR43_RS01840	COG3022	response to hydroperoxide
BBR43_RS01845	COG0442	prolyl-tRNA aminoacylation
BBR43_RS01850	COG1652	LysM domain
BBR43_RS01855	COG2409	Drug exporters of the RND superfamily
BBR43_RS01865	COG0779	Required for maturation of 30S ribosomal subunits
BBR43_RS01880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BBR43_RS01885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BBR43_RS01900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BBR43_RS01905	COG2977	Belongs to the P-Pant transferase superfamily
BBR43_RS01910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BBR43_RS01925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BBR43_RS01940	COG1185	polyribonucleotide nucleotidyltransferase activity
BBR43_RS01955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BBR43_RS01960	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BBR43_RS01965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBR43_RS01970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBR43_RS01980	COG1674	ftsk spoiiie
BBR43_RS02005	COG1396	sequence-specific DNA binding
BBR43_RS02010	COG1842	Phage shock protein A
BBR43_RS02015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BBR43_RS02020	COG1122	ATPase activity
BBR43_RS02035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BBR43_RS02040	COG2137	regulation of response to DNA damage stimulus
BBR43_RS02045	COG0765	amino acid transport
BBR43_RS02050	COG0765	amino acid transport
BBR43_RS02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBR43_RS02060	COG1126	abc transporter atp-binding protein
BBR43_RS02080	COG1196	nuclear chromosome segregation
BBR43_RS02090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BBR43_RS02095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBR43_RS02110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBR43_RS02115	COG2233	PERMEase
BBR43_RS02120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBR43_RS02125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBR43_RS02125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBR43_RS02125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBR43_RS02130	COG1105	Belongs to the carbohydrate kinase PfkB family
BBR43_RS02135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBR43_RS02140	COG1349	DNA-binding transcription factor activity
BBR43_RS02145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BBR43_RS02155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBR43_RS02160	COG1643	Atp-dependent helicase
BBR43_RS02170	COG0583	DNA-binding transcription factor activity
BBR43_RS02175	COG0450	alkyl hydroperoxide reductase
BBR43_RS02180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BBR43_RS02200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBR43_RS02205	COG1321	iron dependent repressor
BBR43_RS02220	COG1760	l-serine dehydratase
BBR43_RS02225	COG0814	amino acid
BBR43_RS02265	COG0156	8-amino-7-oxononanoate synthase activity
BBR43_RS02285	COG2084	Dehydrogenase
BBR43_RS02290	COG2610	gluconate transmembrane transporter activity
BBR43_RS02310	COG0659	secondary active sulfate transmembrane transporter activity
BBR43_RS02315	COG3949	Membrane
BBR43_RS02320	COG0657	acetylesterase activity
BBR43_RS02405	COG2376	Dihydroxyacetone kinase
BBR43_RS02410	COG1461	Dihydroxyacetone kinase
BBR43_RS02415	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BBR43_RS02445	COG0477	Major facilitator Superfamily
BBR43_RS02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBR43_RS02455	COG1609	Transcriptional regulator
BBR43_RS02470	COG4585	Histidine kinase
BBR43_RS02475	COG2197	response regulator
BBR43_RS02525	COG0756	dUTP diphosphatase activity
BBR43_RS02540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBR43_RS02545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBR43_RS02560	COG3253	May function as heme-dependent peroxidase
BBR43_RS02565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBR43_RS02620	COG2847	Copper chaperone PCu(A)C
BBR43_RS02625	COG2837	iron assimilation
BBR43_RS02630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BBR43_RS02640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBR43_RS02645	COG1560	Kdo2-lipid A biosynthetic process
BBR43_RS02650	COG0438	transferase activity, transferring glycosyl groups
BBR43_RS02670	COG1946	Acyl-CoA thioesterase
BBR43_RS02675	COG0217	transcriptional regulatory protein
BBR43_RS02680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BBR43_RS02685	COG0632	four-way junction helicase activity
BBR43_RS02690	COG2255	four-way junction helicase activity
BBR43_RS02695	COG1862	Preprotein translocase
BBR43_RS02705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBR43_RS02710	COG0747	negative chemotaxis
BBR43_RS02715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BBR43_RS02720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBR43_RS02725	COG2323	membrane
BBR43_RS02740	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BBR43_RS02745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBR43_RS02750	COG0124	histidyl-tRNA synthetase
BBR43_RS02760	COG1760	l-serine dehydratase
BBR43_RS02775	COG0431	NADPH-dependent FMN reductase
BBR43_RS02780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBR43_RS02840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BBR43_RS02860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BBR43_RS02870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBR43_RS02880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BBR43_RS02885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BBR43_RS02890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BBR43_RS02895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBR43_RS02900	COG0006	proline dipeptidase activity
BBR43_RS02905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBR43_RS02910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBR43_RS02920	COG0765	amino acid transport
BBR43_RS02950	COG2226	methyltransferase
BBR43_RS02955	COG0539	negative regulation of cytoplasmic translation
BBR43_RS02985	COG3973	AAA domain
BBR43_RS03015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BBR43_RS03020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BBR43_RS03025	COG2314	TM2 domain
BBR43_RS03030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBR43_RS03035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BBR43_RS03040	COG0072	phenylalanine-tRNA ligase activity
BBR43_RS03040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBR43_RS03045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BBR43_RS03060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBR43_RS03065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BBR43_RS03070	COG1438	arginine binding
BBR43_RS03075	COG0137	argininosuccinate synthase activity
BBR43_RS03080	COG0165	Argininosuccinate lyase
BBR43_RS03120	COG0647	UMP catabolic process
BBR43_RS03130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BBR43_RS03150	COG0494	nUDIX hydrolase
BBR43_RS03155	COG4974	Belongs to the 'phage' integrase family
BBR43_RS03170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BBR43_RS03180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BBR43_RS03185	COG1160	GTP binding
BBR43_RS03190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BBR43_RS03205	COG1132	(ABC) transporter
BBR43_RS03230	COG0732	type I restriction modification DNA specificity domain
BBR43_RS03255	COG3012	SEC-C Motif Domain Protein
BBR43_RS03265	COG0653	protein targeting
BBR43_RS03270	COG1716	ATPase activity
BBR43_RS03300	COG0513	Belongs to the DEAD box helicase family
BBR43_RS03305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BBR43_RS03315	COG0598	Magnesium transport protein CorA
BBR43_RS03325	COG0351	phosphomethylpyrimidine kinase
BBR43_RS03325	COG0352	thiamine-phosphate diphosphorylase activity
BBR43_RS03325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BBR43_RS03330	COG1252	NADH dehydrogenase
BBR43_RS03365	COG0463	Glycosyl transferase, family 2
BBR43_RS03385	COG0300	oxidoreductase activity
BBR43_RS03425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BBR43_RS03435	COG4122	O-methyltransferase activity
BBR43_RS03440	COG1222	aaa ATPase
BBR43_RS03450	COG1362	aminopeptidase activity
BBR43_RS03465	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BBR43_RS03470	COG1027	Aspartate ammonia-lyase
BBR43_RS03475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BBR43_RS03480	COG0140	phosphoribosyl-ATP diphosphatase activity
BBR43_RS03485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBR43_RS03495	COG0215	cysteine-tRNA ligase activity
BBR43_RS03500	COG1968	undecaprenyl-diphosphatase activity
BBR43_RS03510	COG0167	dihydroorotate dehydrogenase activity
BBR43_RS03535	COG0586	Pfam SNARE associated Golgi protein
BBR43_RS03560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BBR43_RS03565	COG0791	NLP P60 protein
BBR43_RS03565	COG3883	PFAM NLP P60 protein
BBR43_RS03575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BBR43_RS03590	COG3830	Belongs to the UPF0237 family
BBR43_RS03595	COG2848	UPF0210 protein
BBR43_RS03625	COG0488	(ABC) transporter
BBR43_RS03630	COG2151	metal-sulfur cluster biosynthetic enzyme
BBR43_RS03635	COG0822	iron-sulfur transferase activity
BBR43_RS03645	COG0396	ATPase activity
BBR43_RS03650	COG0719	Fe-S assembly protein
BBR43_RS03655	COG0719	Fe-S assembly protein
BBR43_RS03700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBR43_RS03720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBR43_RS03730	COG0126	phosphoglycerate kinase activity
BBR43_RS03735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBR43_RS03740	COG1481	regulation of sporulation
BBR43_RS03750	COG1660	Displays ATPase and GTPase activities
BBR43_RS03755	COG0322	excinuclease ABC activity
BBR43_RS03765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BBR43_RS03795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BBR43_RS03800	COG0242	peptide deformylase activity
BBR43_RS03810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BBR43_RS03820	COG1758	RNA polymerase activity
BBR43_RS03840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BBR43_RS03845	COG0505	Belongs to the CarA family
BBR43_RS03850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBR43_RS03855	COG0540	Belongs to the ATCase OTCase family
BBR43_RS03895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BBR43_RS03900	COG0742	ribosomal rna small subunit methyltransferase
BBR43_RS03910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BBR43_RS03920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BBR43_RS03925	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BBR43_RS03935	COG1181	Belongs to the D-alanine--D-alanine ligase family
BBR43_RS03940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BBR43_RS03945	COG0406	alpha-ribazole phosphatase activity
BBR43_RS03945	COG0494	nUDIX hydrolase
BBR43_RS03955	COG0066	3-isopropylmalate dehydratase activity
BBR43_RS03960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BBR43_RS03970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBR43_RS03990	COG4584	PFAM Integrase catalytic
BBR43_RS04000	COG1484	DNA-dependent DNA replication
BBR43_RS04030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBR43_RS04100	COG1121	(ABC) transporter
BBR43_RS04105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBR43_RS04135	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBR43_RS04145	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BBR43_RS04150	COG0473	3-isopropylmalate dehydrogenase activity
BBR43_RS04240	COG4584	PFAM Integrase catalytic
BBR43_RS04260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BBR43_RS04265	COG0440	acetolactate synthase activity
BBR43_RS04270	COG0028	Belongs to the TPP enzyme family
BBR43_RS04280	COG0129	dihydroxy-acid dehydratase activity
BBR43_RS04285	COG5650	phosphatidylinositol metabolic process
BBR43_RS04305	COG0435	Glutathione S-transferase
BBR43_RS04310	COG0583	DNA-binding transcription factor activity
BBR43_RS04325	COG3949	Membrane
BBR43_RS04330	COG1064	alcohol dehydrogenase
BBR43_RS04340	COG0205	6-phosphofructokinase activity
BBR43_RS04365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BBR43_RS04380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BBR43_RS04415	COG0482	sulfurtransferase activity
BBR43_RS04435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BBR43_RS04440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBR43_RS04450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BBR43_RS04470	COG1119	ATPase activity
BBR43_RS04475	COG0366	Alpha amylase catalytic
BBR43_RS04485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBR43_RS04495	COG1301	dicarboxylic acid transport
BBR43_RS04515	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
BBR43_RS04525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBR43_RS04530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BBR43_RS04540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BBR43_RS04545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBR43_RS04555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBR43_RS04560	COG0356	it plays a direct role in the translocation of protons across the membrane
BBR43_RS04570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBR43_RS04585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBR43_RS04600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BBR43_RS04610	COG0315	cyclic pyranopterin monophosphate synthase activity
BBR43_RS04615	COG0746	molybdenum cofactor guanylyltransferase activity
BBR43_RS04620	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBR43_RS04620	COG0315	cyclic pyranopterin monophosphate synthase activity
BBR43_RS04635	COG1140	nitrate reductase beta subunit
BBR43_RS04685	COG0083	homoserine kinase activity
BBR43_RS04690	COG0460	homoserine dehydrogenase
BBR43_RS04695	COG0019	diaminopimelate decarboxylase activity
BBR43_RS04700	COG0018	arginyl-trna synthetase
BBR43_RS04705	COG1620	l-lactate permease
BBR43_RS04710	COG0247	lactate metabolic process
BBR43_RS04715	COG1139	Iron-sulfur cluster binding protein
BBR43_RS04720	COG1556	Lactate utilization protein
BBR43_RS04735	COG0662	Cupin 2, conserved barrel domain protein
BBR43_RS04750	COG1846	Transcriptional regulator
BBR43_RS04770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBR43_RS04775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBR43_RS04795	COG2755	lipolytic protein G-D-S-L family
BBR43_RS04800	COG1228	amidohydrolase
BBR43_RS04805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BBR43_RS04815	COG2986	histidine ammonia-lyase
BBR43_RS04825	COG0010	Belongs to the arginase family
BBR43_RS04835	COG3314	Sporulation integral membrane protein YlbJ
BBR43_RS04840	COG0494	nUDIX hydrolase
BBR43_RS04855	COG0247	lactate metabolic process
BBR43_RS04855	COG0277	FAD linked oxidase domain protein
BBR43_RS04875	COG2814	Major facilitator Superfamily
BBR43_RS04895	COG2272	Belongs to the type-B carboxylesterase lipase family
BBR43_RS04905	COG0567	Dehydrogenase, E1 component
BBR43_RS04905	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBR43_RS04930	COG1595	DNA-templated transcription, initiation
BBR43_RS04935	COG4122	O-methyltransferase activity
BBR43_RS04940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBR43_RS04945	COG0297	glycogen (starch) synthase activity
BBR43_RS04955	COG2226	methyltransferase
BBR43_RS04970	COG0463	Glycosyl transferase, family 2
BBR43_RS04980	COG1611	Belongs to the LOG family
BBR43_RS04985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBR43_RS04990	COG1113	amino acid transport
BBR43_RS05000	COG1113	amino acid transport
BBR43_RS05015	COG0564	pseudouridine synthase activity
BBR43_RS05050	COG1217	gtp-binding protein TYPA
BBR43_RS05065	COG2354	Protein conserved in bacteria
BBR43_RS05070	COG0428	transporter
BBR43_RS05100	COG0709	Synthesizes selenophosphate from selenide and ATP
BBR43_RS05110	COG2391	methyltransferase activity
BBR43_RS05120	COG0437	4 iron, 4 sulfur cluster binding
BBR43_RS05125	COG0243	molybdopterin cofactor binding
BBR43_RS05125	COG3383	formate dehydrogenase (NAD+) activity
BBR43_RS05130	COG3383	formate dehydrogenase (NAD+) activity
BBR43_RS05130	COG0243	molybdopterin cofactor binding
BBR43_RS05145	COG1301	dicarboxylic acid transport
BBR43_RS05165	COG2814	Major facilitator Superfamily
BBR43_RS05170	COG0523	cobalamin synthesis protein
BBR43_RS05180	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS05185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BBR43_RS05190	COG0012	GTP binding
BBR43_RS05195	COG0628	permease
BBR43_RS05200	COG1322	Protein conserved in bacteria
BBR43_RS05215	COG1570	exodeoxyribonuclease VII activity
BBR43_RS05220	COG1722	exodeoxyribonuclease VII activity
BBR43_RS05235	COG1494	fructose-1,6-bisphosphatase
BBR43_RS05240	COG0114	fumarate hydratase activity
BBR43_RS05245	COG1309	transcriptional regulator
BBR43_RS05255	COG0693	protein deglycase activity
BBR43_RS05265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BBR43_RS05290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBR43_RS05290	COG0512	Glutamine amidotransferase of anthranilate synthase
BBR43_RS05295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BBR43_RS05300	COG1072	(Pantothenic acid kinase))
BBR43_RS05320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BBR43_RS05375	COG0148	phosphopyruvate hydratase activity
BBR43_RS05390	COG3956	TIGRFAM MazG family protein
BBR43_RS05395	COG0531	amino acid
BBR43_RS05445	COG2132	Multicopper oxidase
BBR43_RS05455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BBR43_RS05460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BBR43_RS05475	COG0193	aminoacyl-tRNA hydrolase activity
BBR43_RS05480	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBR43_RS05485	COG2326	polyphosphate kinase activity
BBR43_RS05500	COG0193	aminoacyl-tRNA hydrolase activity
BBR43_RS05510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BBR43_RS05515	COG2610	gluconate transmembrane transporter activity
BBR43_RS05520	COG1309	transcriptional regulator
BBR43_RS05540	COG0123	including yeast histone deacetylase and acetoin utilization protein
BBR43_RS05555	COG1960	acyl-CoA dehydrogenase activity
BBR43_RS05565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBR43_RS05580	COG1024	Enoyl-CoA hydratase
BBR43_RS05585	COG0183	Belongs to the thiolase family
BBR43_RS05610	COG2409	Drug exporters of the RND superfamily
BBR43_RS05640	COG0561	phosphatase activity
BBR43_RS05645	COG2755	lipolytic protein G-D-S-L family
BBR43_RS05645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBR43_RS05665	COG0488	(ABC) transporter
BBR43_RS05685	COG3583	domain protein
BBR43_RS05690	COG0084	hydrolase, TatD family'
BBR43_RS05695	COG1247	-acetyltransferase
BBR43_RS05715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBR43_RS05725	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
BBR43_RS05735	COG2259	Doxx family
BBR43_RS05740	COG0519	Catalyzes the synthesis of GMP from XMP
BBR43_RS05760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BBR43_RS05785	COG0315	cyclic pyranopterin monophosphate synthase activity
BBR43_RS05785	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBR43_RS05790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBR43_RS05800	COG0745	RESPONSE REGULATOR receiver
BBR43_RS05810	COG0254	rRNA binding
BBR43_RS05815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BBR43_RS05825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBR43_RS05830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BBR43_RS05875	COG0138	bifunctional purine biosynthesis protein purh
BBR43_RS05925	COG1605	Chorismate mutase
BBR43_RS05930	COG2056	Na+-H+ antiporter family
BBR43_RS05955	COG3304	Inner membrane component domain
BBR43_RS05980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BBR43_RS05990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBR43_RS06015	COG1733	regulation of RNA biosynthetic process
BBR43_RS06020	COG1201	RNA secondary structure unwinding
BBR43_RS06025	COG1218	3'(2'),5'-bisphosphate nucleotidase
BBR43_RS06030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BBR43_RS06040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBR43_RS06065	COG3757	hydrolase, family 25
BBR43_RS06075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBR43_RS06090	COG0545	Peptidyl-prolyl cis-trans isomerase
BBR43_RS06095	COG0372	Belongs to the citrate synthase family
BBR43_RS06115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBR43_RS06120	COG2252	PERMEase
BBR43_RS06145	COG1652	LysM domain
BBR43_RS06180	COG1484	DNA-dependent DNA replication
BBR43_RS06185	COG4584	PFAM Integrase catalytic
BBR43_RS06235	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BBR43_RS06240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBR43_RS06260	COG0814	amino acid
BBR43_RS06275	COG2177	Part of the ABC transporter FtsEX involved in
BBR43_RS06280	COG2884	Cell division ATP-binding protein ftsE
BBR43_RS06285	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBR43_RS06290	COG0483	inositol monophosphate 1-phosphatase activity
BBR43_RS06295	COG0483	inositol monophosphate 1-phosphatase activity
BBR43_RS06305	COG2985	domain, Protein
BBR43_RS06305	COG0569	domain protein
BBR43_RS06325	COG2801	Transposase and inactivated derivatives
BBR43_RS06335	COG1132	(ABC) transporter
BBR43_RS06340	COG1132	(ABC) transporter
BBR43_RS06340	COG2375	cellular response to nickel ion
BBR43_RS06370	COG3480	Lon protease (S16) C-terminal proteolytic domain
BBR43_RS06400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBR43_RS06430	COG0513	Belongs to the DEAD box helicase family
BBR43_RS06460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBR43_RS06465	COG2135	peptidase activity
BBR43_RS06475	COG1162	GTPase activity
BBR43_RS06500	COG0653	protein targeting
BBR43_RS06505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBR43_RS06515	COG5401	PFAM Sporulation and spore germination
BBR43_RS06520	COG5002	protein histidine kinase activity
BBR43_RS06520	COG5000	phosphorelay sensor kinase activity
BBR43_RS06525	COG0745	RESPONSE REGULATOR receiver
BBR43_RS06550	COG1482	cell wall glycoprotein biosynthetic process
BBR43_RS06565	COG0730	response to heat
BBR43_RS06580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BBR43_RS06590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBR43_RS06620	COG1316	TRANSCRIPTIONal
BBR43_RS06630	COG0583	DNA-binding transcription factor activity
BBR43_RS06635	COG0028	Belongs to the TPP enzyme family
BBR43_RS06640	COG0814	amino acid
BBR43_RS06645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBR43_RS06670	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS06695	COG1175	transmembrane transport
BBR43_RS06705	COG1653	transport
BBR43_RS06710	COG3842	ATPase activity
BBR43_RS06745	COG0814	amino acid
BBR43_RS06755	COG1115	amino acid carrier protein
BBR43_RS06765	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS06775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBR43_RS06795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBR43_RS06805	COG2235	arginine
BBR43_RS06810	COG0814	amino acid
BBR43_RS06820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBR43_RS06830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBR43_RS06890	COG3265	gluconokinase activity
BBR43_RS06910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBR43_RS06910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBR43_RS06910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBR43_RS06925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBR43_RS06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBR43_RS06945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BBR43_RS06950	COG1984	allophanate hydrolase subunit 2
BBR43_RS06955	COG4770	biotin carboxylase activity
BBR43_RS06960	COG1802	Transcriptional regulator
BBR43_RS06965	COG4336	lyase activity
BBR43_RS06970	COG1914	H( )-stimulated, divalent metal cation uptake system
BBR43_RS06975	COG2040	homocysteine
BBR43_RS06980	COG0183	Belongs to the thiolase family
BBR43_RS06985	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBR43_RS06985	COG1024	Enoyl-CoA hydratase
BBR43_RS07000	COG1309	transcriptional regulator
BBR43_RS07030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBR43_RS07045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBR43_RS07060	COG1609	Transcriptional regulator
BBR43_RS07075	COG3527	Alpha-acetolactate decarboxylase
BBR43_RS07095	COG3842	ATPase activity
BBR43_RS07145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBR43_RS07150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBR43_RS07160	COG0424	maF-like protein
BBR43_RS07180	COG0189	ligase activity
BBR43_RS07185	COG2897	thiosulfate sulfurtransferase activity
BBR43_RS07190	COG4770	biotin carboxylase activity
BBR43_RS07195	COG0456	acetyltransferase
BBR43_RS07210	COG0577	efflux transmembrane transporter activity
BBR43_RS07210	COG1136	(ABC) transporter
BBR43_RS07220	COG0372	Belongs to the citrate synthase family
BBR43_RS07225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BBR43_RS07230	COG2079	MmgE PrpD family protein
BBR43_RS07235	COG1396	sequence-specific DNA binding
BBR43_RS07235	COG3800	Transcriptional regulator
BBR43_RS07250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BBR43_RS07250	COG1473	amidohydrolase
BBR43_RS07260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BBR43_RS07280	COG0657	acetylesterase activity
BBR43_RS07290	COG1686	Belongs to the peptidase S11 family
BBR43_RS07305	COG0180	Tryptophanyl-tRNA synthetase
BBR43_RS07325	COG2814	Major facilitator Superfamily
BBR43_RS07335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBR43_RS07340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBR43_RS07355	COG2838	Isocitrate dehydrogenase
BBR43_RS07395	COG0339	signal peptide processing
BBR43_RS07420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBR43_RS07430	COG1595	DNA-templated transcription, initiation
BBR43_RS07445	COG2873	o-acetylhomoserine
BBR43_RS07450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BBR43_RS07460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BBR43_RS07465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBR43_RS07510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBR43_RS07515	COG0587	DNA-directed DNA polymerase activity
BBR43_RS07525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBR43_RS07530	COG2011	ABC-type metal ion transport system permease component
BBR43_RS07560	COG2197	response regulator
BBR43_RS07580	COG1136	(ABC) transporter
BBR43_RS07585	COG0577	efflux transmembrane transporter activity
BBR43_RS07615	COG0583	DNA-binding transcription factor activity
BBR43_RS07625	COG0516	GMP reductase activity
BBR43_RS07665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBR43_RS07680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BBR43_RS07685	COG0456	acetyltransferase
BBR43_RS07700	COG2985	domain, Protein
BBR43_RS07700	COG0569	domain protein
BBR43_RS07710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBR43_RS07720	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBR43_RS07720	COG0596	Alpha beta hydrolase
BBR43_RS07740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBR43_RS07745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BBR43_RS07770	COG1674	ftsk spoiiie
BBR43_RS07780	COG1404	Belongs to the peptidase S8 family
BBR43_RS07795	COG0101	tRNA pseudouridine synthase activity
BBR43_RS07800	COG2860	membrane
BBR43_RS07805	COG0203	ribosomal protein L17
BBR43_RS07810	COG0202	RNA polymerase activity
BBR43_RS07815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BBR43_RS07820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BBR43_RS07825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BBR43_RS07845	COG0563	adenylate kinase activity
BBR43_RS07850	COG0201	protein transport
BBR43_RS07855	COG0200	Binds to the 23S rRNA
BBR43_RS07860	COG1841	ribosomal large subunit assembly
BBR43_RS07865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BBR43_RS07870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BBR43_RS07875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BBR43_RS07890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BBR43_RS07930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BBR43_RS07935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BBR43_RS07940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BBR43_RS07955	COG1621	beta-fructofuranosidase activity
BBR43_RS07960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBR43_RS08050	COG2801	Transposase and inactivated derivatives
BBR43_RS08055	COG2801	Transposase and inactivated derivatives
BBR43_RS08070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BBR43_RS08075	COG0255	Belongs to the universal ribosomal protein uL29 family
BBR43_RS08080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BBR43_RS08085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BBR43_RS08090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BBR43_RS08095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BBR43_RS08100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BBR43_RS08105	COG0089	rRNA binding
BBR43_RS08110	COG0088	Forms part of the polypeptide exit tunnel
BBR43_RS08120	COG0051	transcription antitermination factor activity, RNA binding
BBR43_RS08125	COG1302	Protein conserved in bacteria
BBR43_RS08160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBR43_RS08165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BBR43_RS08170	COG0049	tRNA binding
BBR43_RS08175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BBR43_RS08185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BBR43_RS08200	COG4172	Belongs to the ABC transporter superfamily
BBR43_RS08205	COG4721	ABC-type cobalt transport system, permease component
BBR43_RS08215	COG4584	PFAM Integrase catalytic
BBR43_RS08220	COG1484	DNA-dependent DNA replication
BBR43_RS08230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BBR43_RS08245	COG0222	ribosome binding
BBR43_RS08250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BBR43_RS08255	COG0415	Belongs to the DNA photolyase family
BBR43_RS08275	COG2197	response regulator
BBR43_RS08285	COG2151	metal-sulfur cluster biosynthetic enzyme
BBR43_RS08285	COG0489	protein tyrosine kinase activity
BBR43_RS08320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBR43_RS08365	COG0081	regulation of translation
BBR43_RS08370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BBR43_RS08375	COG0250	Participates in transcription elongation, termination and antitermination
BBR43_RS08380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBR43_RS08405	COG0142	geranyltranstransferase activity
BBR43_RS08415	COG2226	methyltransferase
BBR43_RS08420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BBR43_RS08420	COG0438	transferase activity, transferring glycosyl groups
BBR43_RS08445	COG4948	Mandelate Racemase Muconate Lactonizing
BBR43_RS08450	COG3069	C4-dicarboxylate transmembrane transporter activity
BBR43_RS08455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BBR43_RS08465	COG0803	Belongs to the bacterial solute-binding protein 9 family
BBR43_RS08470	COG1121	(ABC) transporter
BBR43_RS08490	COG1321	iron dependent repressor
BBR43_RS08525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBR43_RS08535	COG0785	Cytochrome C biogenesis protein
BBR43_RS08545	COG0406	alpha-ribazole phosphatase activity
BBR43_RS08550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BBR43_RS08560	COG2084	Dehydrogenase
BBR43_RS08590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BBR43_RS08615	COG1648	precorrin-2 dehydrogenase activity
BBR43_RS08615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BBR43_RS08620	COG0181	hydroxymethylbilane synthase activity
BBR43_RS08625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BBR43_RS08650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBR43_RS08675	COG5002	protein histidine kinase activity
BBR43_RS08685	COG0438	transferase activity, transferring glycosyl groups
BBR43_RS08690	COG0318	PFAM AMP-dependent synthetase and ligase
BBR43_RS08700	COG0318	PFAM AMP-dependent synthetase and ligase
BBR43_RS08705	COG0318	PFAM AMP-dependent synthetase and ligase
BBR43_RS08715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBR43_RS08720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BBR43_RS08765	COG1690	Belongs to the RtcB family
BBR43_RS08805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBR43_RS08810	COG1373	ATPase (AAA superfamily
BBR43_RS08820	COG1854	S-ribosylhomocysteine lyase activity
BBR43_RS08825	COG0667	Aldo Keto reductase
BBR43_RS08835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBR43_RS08855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BBR43_RS08870	COG2733	membrane
BBR43_RS08880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBR43_RS08885	COG1053	succinate dehydrogenase
BBR43_RS08895	COG1396	sequence-specific DNA binding
BBR43_RS08895	COG3800	Transcriptional regulator
BBR43_RS08900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBR43_RS08920	COG1088	dTDP-glucose 4,6-dehydratase activity
BBR43_RS08930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BBR43_RS08950	COG0318	PFAM AMP-dependent synthetase and ligase
BBR43_RS09010	COG0470	DNA polymerase III
BBR43_RS09020	COG2311	Membrane
BBR43_RS09030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBR43_RS09030	COG1754	DNA topoisomerase type I activity
BBR43_RS09040	COG1278	Cold shock
BBR43_RS09045	COG1205	dead DEAH box helicase
BBR43_RS09045	COG1111	helicase
BBR43_RS09105	COG4166	transmembrane transport
BBR43_RS09115	COG0601	transmembrane transport
BBR43_RS09120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBR43_RS09135	COG1484	DNA-dependent DNA replication
BBR43_RS09140	COG4584	PFAM Integrase catalytic
BBR43_RS09190	COG1002	Type II restriction enzyme, methylase subunits
BBR43_RS09300	COG2197	response regulator
BBR43_RS09400	COG1968	undecaprenyl-diphosphatase activity
BBR43_RS09425	COG1132	(ABC) transporter
BBR43_RS09430	COG5265	(ABC) transporter
BBR43_RS09450	COG2205	protein histidine kinase activity
BBR43_RS09455	COG0745	RESPONSE REGULATOR receiver
BBR43_RS09465	COG5640	endopeptidase activity
BBR43_RS09475	COG1192	Involved in chromosome partitioning
BBR43_RS09520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBR43_RS09530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBR43_RS09535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBR43_RS09540	COG0251	oxidation-reduction process
BBR43_RS09580	COG0659	secondary active sulfate transmembrane transporter activity
BBR43_RS09585	COG0789	Transcriptional regulator
BBR43_RS09615	COG4584	PFAM Integrase catalytic
BBR43_RS09620	COG1484	DNA-dependent DNA replication
BBR43_RS09630	COG5479	isomerase activity
BBR43_RS09630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBR43_RS09650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBR43_RS09685	COG3949	Membrane
BBR43_RS09690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBR43_RS09695	COG0527	aspartate kinase activity
BBR43_RS09700	COG0697	spore germination
BBR43_RS09735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BBR43_RS09740	COG1492	cobalamin metabolic process
BBR43_RS09765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBR43_RS09785	COG2169	Transcriptional regulator
BBR43_RS09785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBR43_RS09800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBR43_RS09800	COG2755	lipolytic protein G-D-S-L family
BBR43_RS09810	COG0025	NhaP-type Na H and K H
BBR43_RS09835	COG1100	Small GTP-binding protein
BBR43_RS09880	COG0343	queuine tRNA-ribosyltransferase activity
BBR43_RS09885	COG2409	Drug exporters of the RND superfamily
BBR43_RS09895	COG3237	CsbD-like
BBR43_RS09900	COG0590	tRNA wobble adenosine to inosine editing
BBR43_RS09910	COG0287	Prephenate dehydrogenase
BBR43_RS09930	COG0471	metal ion transport
BBR43_RS09945	COG2315	Protein conserved in bacteria
BBR43_RS09950	COG0569	domain protein
BBR43_RS09955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBR43_RS09960	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS10000	COG3961	Belongs to the TPP enzyme family
BBR43_RS10020	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBR43_RS10040	COG0604	alcohol dehydrogenase
BBR43_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
BBR43_RS10040	COG3321	synthase
BBR43_RS10065	COG1216	Glycosyl transferase, family 2
BBR43_RS10095	COG0277	FAD linked oxidase domain protein
BBR43_RS10125	COG3590	peptidase
BBR43_RS10135	COG2339	peptidase activity
BBR43_RS10150	COG2501	S4 domain
BBR43_RS10170	COG1280	lysine exporter protein (LysE YggA)
BBR43_RS10175	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BBR43_RS10180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBR43_RS10185	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS10195	COG0431	NADPH-dependent FMN reductase
BBR43_RS10210	COG1643	Atp-dependent helicase
BBR43_RS10215	COG0730	response to heat
BBR43_RS10220	COG3180	Ammonia monooxygenase
BBR43_RS10235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBR43_RS10255	COG1528	Iron-storage protein
BBR43_RS10275	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BBR43_RS10280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BBR43_RS10285	COG1764	response to oxidative stress
BBR43_RS10300	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BBR43_RS10325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBR43_RS10335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BBR43_RS10340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBR43_RS10360	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BBR43_RS10370	COG2197	response regulator
BBR43_RS10380	COG1136	(ABC) transporter
BBR43_RS10380	COG0577	efflux transmembrane transporter activity
BBR43_RS10395	COG3104	oligopeptide transport
BBR43_RS10400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BBR43_RS10445	COG0477	Major facilitator Superfamily
BBR43_RS10450	COG1309	transcriptional regulator
BBR43_RS10500	COG1484	DNA-dependent DNA replication
BBR43_RS10530	COG2132	Multicopper oxidase
BBR43_RS10540	COG0745	RESPONSE REGULATOR receiver
BBR43_RS10555	COG2217	Heavy metal translocating P-type atpase
BBR43_RS10600	COG1716	ATPase activity
BBR43_RS10600	COG1716	ATPase activity
BBR43_RS10605	COG1716	ATPase activity
BBR43_RS10620	COG0768	penicillin binding
BBR43_RS10625	COG0515	serine threonine protein kinase
BBR43_RS10630	COG0515	serine threonine protein kinase
BBR43_RS10630	COG2815	serine threonine protein kinase
BBR43_RS10685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BBR43_RS10730	COG0726	polysaccharide deacetylase
BBR43_RS10735	COG2094	Belongs to the DNA glycosylase MPG family
BBR43_RS10750	COG0045	succinate-CoA ligase (ADP-forming) activity
BBR43_RS10770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBR43_RS10795	COG0187	DNA topoisomerase II activity
BBR43_RS10805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BBR43_RS10810	COG0592	DNA-directed DNA polymerase activity
BBR43_RS10815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBR43_RS10820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BBR43_RS10825	COG0594	ribonuclease P activity
BBR43_RS10830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BBR43_RS10835	COG0706	membrane insertase activity
BBR43_RS10845	COG1192	Involved in chromosome partitioning
BBR43_RS10860	COG0860	N-Acetylmuramoyl-L-alanine amidase
BBR43_RS10860	COG3409	Peptidoglycan-binding domain 1 protein
BBR43_RS10865	COG3118	belongs to the thioredoxin family
BBR43_RS10875	COG1595	DNA-templated transcription, initiation
BBR43_RS10905	COG0617	tRNA 3'-terminal CCA addition
BBR43_RS10910	COG1678	Uncharacterized ACR, COG1678
BBR43_RS10915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BBR43_RS10935	COG1902	pentaerythritol trinitrate reductase activity
BBR43_RS10955	COG1823	symporter activity
BBR43_RS10965	COG0159	tryptophan synthase activity
BBR43_RS10975	COG0134	indole-3-glycerol-phosphate synthase activity
BBR43_RS10975	COG0135	phosphoribosylanthranilate isomerase activity
BBR43_RS10980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBR43_RS10985	COG0512	Glutamine amidotransferase of anthranilate synthase
BBR43_RS10990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBR43_RS11005	COG0477	Major facilitator Superfamily
BBR43_RS11010	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBR43_RS11015	COG1802	Transcriptional regulator
BBR43_RS11020	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS11030	COG3971	2-oxopent-4-enoate hydratase activity
BBR43_RS11055	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS11085	COG1136	(ABC) transporter
BBR43_RS11085	COG0577	efflux transmembrane transporter activity
BBR43_RS11105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BBR43_RS11110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BBR43_RS11115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBR43_RS11120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBR43_RS11125	COG1120	ATPase activity
BBR43_RS11155	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BBR43_RS11165	COG1132	(ABC) transporter
BBR43_RS11195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBR43_RS11205	COG3177	Filamentation induced by cAMP protein fic
BBR43_RS11290	COG4824	toxin secretion phage lysis holin
BBR43_RS11355	COG0740	serine-type endopeptidase activity
BBR43_RS11360	COG4695	Portal protein
BBR43_RS11365	COG1802	Transcriptional regulator
BBR43_RS11365	COG4626	Terminase
BBR43_RS11395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BBR43_RS11455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBR43_RS11455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBR43_RS11515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BBR43_RS11540	COG1715	Restriction endonuclease
BBR43_RS11545	COG3311	Transcriptional regulator
BBR43_RS11555	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BBR43_RS11570	COG2824	Alkylphosphonate utilization operon protein PhnA
BBR43_RS11580	COG1487	ribonuclease activity
BBR43_RS11585	COG0495	leucyl-tRNA aminoacylation
BBR43_RS11605	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS11605	COG2030	dehydratase
BBR43_RS11610	COG2050	protein possibly involved in aromatic compounds catabolism
BBR43_RS11620	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBR43_RS11625	COG1024	Enoyl-CoA hydratase
BBR43_RS11630	COG0183	Belongs to the thiolase family
BBR43_RS11635	COG1024	Enoyl-CoA hydratase
BBR43_RS11640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BBR43_RS11645	COG2151	metal-sulfur cluster biosynthetic enzyme
BBR43_RS11650	COG3396	Phenylacetate-CoA oxygenase
BBR43_RS11655	COG3460	Phenylacetate-CoA oxygenase
BBR43_RS11660	COG3396	Phenylacetate-CoA oxygenase
BBR43_RS11690	COG0604	alcohol dehydrogenase
BBR43_RS11700	COG2072	flavoprotein involved in K transport
BBR43_RS11705	COG2197	response regulator
BBR43_RS11710	COG4585	Histidine kinase
BBR43_RS11715	COG0577	efflux transmembrane transporter activity
BBR43_RS11720	COG0577	efflux transmembrane transporter activity
BBR43_RS11720	COG1136	(ABC) transporter
BBR43_RS11730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BBR43_RS11730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BBR43_RS11740	COG4868	Belongs to the UPF0371 family
BBR43_RS11745	COG1054	Belongs to the UPF0176 family
BBR43_RS11760	COG1846	Transcriptional regulator
BBR43_RS11770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBR43_RS11785	COG0360	Binds together with S18 to 16S ribosomal RNA
BBR43_RS11790	COG0629	single-stranded DNA binding
BBR43_RS11795	COG0359	binds to the 23S rRNA
BBR43_RS11800	COG0305	Participates in initiation and elongation during chromosome replication
BBR43_RS11825	COG4584	PFAM Integrase catalytic
BBR43_RS11825	COG2390	Transcriptional regulator
BBR43_RS11845	COG0477	Major facilitator Superfamily
BBR43_RS11860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBR43_RS11865	COG1842	Phage shock protein A
BBR43_RS11880	COG1131	(ABC) transporter
BBR43_RS11910	COG4584	PFAM Integrase catalytic
BBR43_RS11915	COG1484	DNA-dependent DNA replication
BBR43_RS11945	COG2801	Transposase and inactivated derivatives
BBR43_RS11950	COG2963	transposase activity
BBR43_RS11960	COG0564	pseudouridine synthase activity
BBR43_RS11980	COG0706	membrane insertase activity
BBR43_RS11985	COG3764	Sortase (surface protein transpeptidase)
BBR43_RS11995	COG4585	Histidine kinase
BBR43_RS11995	COG2203	Gaf domain
BBR43_RS12000	COG2197	response regulator
BBR43_RS12020	COG2814	Major facilitator Superfamily
BBR43_RS12035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBR43_RS12060	COG1316	TRANSCRIPTIONal
BBR43_RS12075	COG0077	Prephenate dehydratase
BBR43_RS12095	COG2188	Transcriptional regulator
BBR43_RS12100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BBR43_RS12110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BBR43_RS12115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBR43_RS12120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BBR43_RS12125	COG0561	phosphatase activity
BBR43_RS12140	COG1966	Carbon starvation protein
BBR43_RS12180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBR43_RS12190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BBR43_RS12210	COG1216	Glycosyl transferase, family 2
BBR43_RS12220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BBR43_RS12225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BBR43_RS12230	COG5479	isomerase activity
BBR43_RS12230	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBR43_RS12235	COG5479	isomerase activity
BBR43_RS12235	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBR43_RS12245	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BBR43_RS12250	COG0318	PFAM AMP-dependent synthetase and ligase
BBR43_RS12255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBR43_RS12255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BBR43_RS12255	COG3321	synthase
BBR43_RS12260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBR43_RS12285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BBR43_RS12320	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BBR43_RS12350	COG4981	capsule polysaccharide biosynthetic process
BBR43_RS12365	COG1472	Belongs to the glycosyl hydrolase 3 family
BBR43_RS12375	COG1132	(ABC) transporter
BBR43_RS12385	COG3764	Sortase (surface protein transpeptidase)
BBR43_RS12400	COG1132	(ABC) transporter
BBR43_RS12410	COG1132	(ABC) transporter
BBR43_RS12425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BBR43_RS12450	COG0247	lactate metabolic process
BBR43_RS12450	COG2181	nitrate reductase activity
BBR43_RS12465	COG0175	sulfate reduction
BBR43_RS12490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BBR43_RS12500	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS12505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBR43_RS12510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBR43_RS12515	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBR43_RS12520	COG1120	ATPase activity
BBR43_RS12525	COG0443	Heat shock 70 kDa protein
BBR43_RS12540	COG0789	Transcriptional regulator
BBR43_RS12545	COG1012	belongs to the aldehyde dehydrogenase family
BBR43_RS12575	COG1125	glycine betaine transport
BBR43_RS12575	COG0517	IMP dehydrogenase activity
BBR43_RS12580	COG1174	glycine betaine transport
BBR43_RS12585	COG1174	glycine betaine transport
BBR43_RS12600	COG2897	thiosulfate sulfurtransferase activity
BBR43_RS12610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBR43_RS12625	COG0191	fructose-bisphosphate aldolase activity
BBR43_RS12630	COG4129	membrane
BBR43_RS12640	COG0786	glutamate:sodium symporter activity
BBR43_RS12645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BBR43_RS12655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BBR43_RS12665	COG3711	transcriptional antiterminator
BBR43_RS12675	COG0280	phosphate acetyltransferase
BBR43_RS12680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBR43_RS12695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBR43_RS12710	COG1131	(ABC) transporter
BBR43_RS12720	COG2814	Major facilitator Superfamily
BBR43_RS12740	COG0242	peptide deformylase activity
BBR43_RS12760	COG1051	belongs to the nudix hydrolase family
BBR43_RS12765	COG1320	monovalent cation:proton antiporter activity
BBR43_RS12770	COG2212	antiporter activity
BBR43_RS12780	COG0651	ATP synthesis coupled electron transport
BBR43_RS12790	COG2111	Na H antiporter
BBR43_RS12790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBR43_RS12800	COG1297	OPT oligopeptide transporter protein
BBR43_RS12805	COG0459	protein refolding
BBR43_RS12815	COG2326	polyphosphate kinase activity
BBR43_RS12850	COG0577	efflux transmembrane transporter activity
BBR43_RS12850	COG1136	(ABC) transporter
BBR43_RS12865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBR43_RS12870	COG2027	D-alanyl-D-alanine carboxypeptidase
BBR43_RS12875	COG0037	tRNA processing
BBR43_RS12885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBR43_RS12890	COG0302	gtp cyclohydrolase
BBR43_RS12905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBR43_RS12925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BBR43_RS12940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBR43_RS12945	COG2814	Major facilitator Superfamily
BBR43_RS12960	COG0542	response to heat
BBR43_RS12980	COG1194	a g-specific adenine glycosylase
BBR43_RS12995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BBR43_RS13000	COG2847	Copper chaperone PCu(A)C
BBR43_RS13010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BBR43_RS13030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBR43_RS13035	COG3842	ATPase activity
BBR43_RS13045	COG1609	Transcriptional regulator
BBR43_RS13060	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BBR43_RS13080	COG1309	transcriptional regulator
BBR43_RS13085	COG0477	Major facilitator Superfamily
BBR43_RS13090	COG0028	Belongs to the TPP enzyme family
BBR43_RS13100	COG0745	RESPONSE REGULATOR receiver
BBR43_RS13105	COG2205	protein histidine kinase activity
BBR43_RS13120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBR43_RS13145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBR43_RS13150	COG1272	protein, Hemolysin III
BBR43_RS13160	COG0183	Belongs to the thiolase family
BBR43_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
BBR43_RS13170	COG2030	dehydratase
BBR43_RS13215	COG1597	lipid kinase activity
BBR43_RS13225	COG0456	acetyltransferase
BBR43_RS13245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBR43_RS13265	COG1132	(ABC) transporter
BBR43_RS13270	COG4988	ABC transporter
BBR43_RS13275	COG1294	oxidase, subunit
BBR43_RS13280	COG1271	oxidase subunit
BBR43_RS13295	COG1937	Protein conserved in bacteria
BBR43_RS13325	COG1045	serine acetyltransferase
BBR43_RS13330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBR43_RS13335	COG2197	response regulator
BBR43_RS13360	COG0577	efflux transmembrane transporter activity
BBR43_RS13360	COG1136	(ABC) transporter
BBR43_RS13365	COG1136	(ABC) transporter
BBR43_RS13365	COG0577	efflux transmembrane transporter activity
BBR43_RS13370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBR43_RS13375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBR43_RS13380	COG1115	amino acid carrier protein
BBR43_RS13385	COG0033	Phosphoglucomutase
BBR43_RS13415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BBR43_RS13420	COG2814	Major facilitator Superfamily
BBR43_RS13425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBR43_RS13440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBR43_RS13450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBR43_RS13455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BBR43_RS13475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BBR43_RS13485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BBR43_RS13495	COG3191	aminopeptidase activity
BBR43_RS13510	COG1234	tRNA 3'-trailer cleavage
BBR43_RS13515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BBR43_RS13545	COG1882	Formate acetyltransferase
BBR43_RS13555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BBR43_RS13570	COG0747	negative chemotaxis
BBR43_RS13580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBR43_RS13625	COG0736	holo-[acyl-carrier-protein] synthase activity
BBR43_RS13645	COG1335	isochorismatase
BBR43_RS13650	COG2066	Belongs to the glutaminase family
BBR43_RS13660	COG1376	ErfK ybiS ycfS ynhG family protein
BBR43_RS13690	COG1115	amino acid carrier protein
BBR43_RS13695	COG4221	oxidoreductase activity
BBR43_RS13715	COG0583	DNA-binding transcription factor activity
BBR43_RS13755	COG0668	transmembrane transport
BBR43_RS13780	COG3328	transposase activity
BBR43_RS13810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBR43_RS13830	COG0747	negative chemotaxis
BBR43_RS13840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBR43_RS13855	COG4221	oxidoreductase activity
BBR43_RS13860	COG2188	Transcriptional regulator
BBR43_RS13870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BBR43_RS13905	COG0544	peptidyl-prolyl cis-trans isomerase activity
BBR43_RS13920	COG1484	DNA-dependent DNA replication
BBR43_RS13950	COG4584	PFAM Integrase catalytic
BBR43_RS13955	COG1132	(ABC) transporter
BBR43_RS13960	COG2375	cellular response to nickel ion
BBR43_RS13960	COG1132	(ABC) transporter
BBR43_RS13965	COG1129	ABC transporter
BBR43_RS13985	COG2801	Transposase and inactivated derivatives
BBR43_RS13990	COG1484	DNA-dependent DNA replication
BBR43_RS14035	COG2963	transposase activity
BBR43_RS14045	COG0431	NADPH-dependent FMN reductase
BBR43_RS14055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBR43_RS14060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides