locus-tag	class	description
I6H50_RS00025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H50_RS00035	COG1396	sequence-specific DNA binding
I6H50_RS00035	COG3800	Transcriptional regulator
I6H50_RS00045	COG1053	succinate dehydrogenase
I6H50_RS00050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H50_RS00060	COG2733	membrane
I6H50_RS00075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6H50_RS00100	COG1854	S-ribosylhomocysteine lyase activity
I6H50_RS00105	COG1295	ribonuclease BN
I6H50_RS00110	COG0318	PFAM AMP-dependent synthetase and ligase
I6H50_RS00115	COG0318	PFAM AMP-dependent synthetase and ligase
I6H50_RS00120	COG2169	Transcriptional regulator
I6H50_RS00120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H50_RS00125	COG0318	PFAM AMP-dependent synthetase and ligase
I6H50_RS00130	COG0438	transferase activity, transferring glycosyl groups
I6H50_RS00135	COG0588	phosphoglycerate mutase activity
I6H50_RS00140	COG5002	protein histidine kinase activity
I6H50_RS00145	COG0745	RESPONSE REGULATOR receiver
I6H50_RS00165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H50_RS00190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6H50_RS00195	COG0181	hydroxymethylbilane synthase activity
I6H50_RS00200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H50_RS00200	COG1648	precorrin-2 dehydrogenase activity
I6H50_RS00235	COG2084	Dehydrogenase
I6H50_RS00240	COG2076	Multidrug Resistance protein
I6H50_RS00245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H50_RS00250	COG0406	alpha-ribazole phosphatase activity
I6H50_RS00260	COG0785	Cytochrome C biogenesis protein
I6H50_RS00265	COG1333	cytochrome c biogenesis protein
I6H50_RS00270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H50_RS00290	COG1575	Belongs to the MenA family. Type 1 subfamily
I6H50_RS00295	COG1321	iron dependent repressor
I6H50_RS00315	COG1121	(ABC) transporter
I6H50_RS00320	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H50_RS00335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H50_RS00345	COG4948	Mandelate Racemase Muconate Lactonizing
I6H50_RS00375	COG0438	transferase activity, transferring glycosyl groups
I6H50_RS00375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H50_RS00380	COG2226	methyltransferase
I6H50_RS00385	COG0644	oxidoreductase
I6H50_RS00390	COG0142	geranyltranstransferase activity
I6H50_RS00430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H50_RS00440	COG2814	Major facilitator Superfamily
I6H50_RS00445	COG0813	purine-nucleoside phosphorylase activity
I6H50_RS00465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H50_RS00470	COG0250	Participates in transcription elongation, termination and antitermination
I6H50_RS00475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H50_RS00480	COG0081	regulation of translation
I6H50_RS00485	COG0019	diaminopimelate decarboxylase activity
I6H50_RS00500	COG0415	Belongs to the DNA photolyase family
I6H50_RS00505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H50_RS00510	COG0222	ribosome binding
I6H50_RS00515	COG3549	Plasmid maintenance system killer
I6H50_RS00535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H50_RS00540	COG4721	ABC-type cobalt transport system, permease component
I6H50_RS00545	COG1122	ATPase activity
I6H50_RS00560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H50_RS00565	COG0049	tRNA binding
I6H50_RS00570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H50_RS00575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H50_RS00610	COG1302	Protein conserved in bacteria
I6H50_RS00615	COG0051	transcription antitermination factor activity, RNA binding
I6H50_RS00620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H50_RS00625	COG0088	Forms part of the polypeptide exit tunnel
I6H50_RS00630	COG0089	rRNA binding
I6H50_RS00635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H50_RS00640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H50_RS00645	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H50_RS00650	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H50_RS00655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H50_RS00660	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H50_RS00665	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H50_RS00680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H50_RS00685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H50_RS00690	COG1120	ATPase activity
I6H50_RS00700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H50_RS00705	COG1621	beta-fructofuranosidase activity
I6H50_RS00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H50_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H50_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H50_RS00745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H50_RS00765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H50_RS00770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H50_RS00775	COG1841	ribosomal large subunit assembly
I6H50_RS00780	COG0200	Binds to the 23S rRNA
I6H50_RS00795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H50_RS00800	COG0201	protein transport
I6H50_RS00805	COG0563	adenylate kinase activity
I6H50_RS00825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H50_RS00830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H50_RS00835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H50_RS00845	COG0203	ribosomal protein L17
I6H50_RS00850	COG0101	tRNA pseudouridine synthase activity
I6H50_RS00860	COG1404	Belongs to the peptidase S8 family
I6H50_RS00870	COG1674	ftsk spoiiie
I6H50_RS00900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H50_RS00945	COG0488	(ABC) transporter
I6H50_RS00950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H50_RS00960	COG0569	domain protein
I6H50_RS00960	COG2985	domain, Protein
I6H50_RS00970	COG1214	PFAM Peptidase M22, glycoprotease
I6H50_RS00970	COG0456	acetyltransferase
I6H50_RS00975	COG0456	acetyltransferase
I6H50_RS00980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H50_RS01005	COG0577	efflux transmembrane transporter activity
I6H50_RS01005	COG1136	(ABC) transporter
I6H50_RS01015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H50_RS01025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H50_RS01055	COG0516	GMP reductase activity
I6H50_RS01100	COG2011	ABC-type metal ion transport system permease component
I6H50_RS01110	COG1464	Belongs to the NlpA lipoprotein family
I6H50_RS01115	COG0587	DNA-directed DNA polymerase activity
I6H50_RS01130	COG3655	Transcriptional regulator
I6H50_RS01150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H50_RS01155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H50_RS01170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H50_RS01175	COG2873	o-acetylhomoserine
I6H50_RS01185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H50_RS01205	COG2838	Isocitrate dehydrogenase
I6H50_RS01210	COG2814	Major facilitator Superfamily
I6H50_RS01220	COG2860	membrane
I6H50_RS01230	COG0180	Tryptophanyl-tRNA synthetase
I6H50_RS01245	COG1686	Belongs to the peptidase S11 family
I6H50_RS01285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H50_RS01295	COG1473	amidohydrolase
I6H50_RS01295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6H50_RS01310	COG1131	(ABC) transporter
I6H50_RS01315	COG2186	Transcriptional regulator
I6H50_RS01320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6H50_RS01340	COG1129	ABC transporter
I6H50_RS01350	COG4770	biotin carboxylase activity
I6H50_RS01355	COG2897	thiosulfate sulfurtransferase activity
I6H50_RS01360	COG0189	ligase activity
I6H50_RS01385	COG0424	maF-like protein
I6H50_RS01395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H50_RS01440	COG3842	ATPase activity
I6H50_RS01455	COG3527	Alpha-acetolactate decarboxylase
I6H50_RS01490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H50_RS01500	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H50_RS01505	COG1129	ABC transporter
I6H50_RS01510	COG1609	Transcriptional regulator
I6H50_RS01540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H50_RS01545	COG0328	RNA-DNA hybrid ribonuclease activity
I6H50_RS01555	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H50_RS01560	COG4336	lyase activity
I6H50_RS01570	COG4770	biotin carboxylase activity
I6H50_RS01575	COG1984	allophanate hydrolase subunit 2
I6H50_RS01580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6H50_RS01595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H50_RS01595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H50_RS01595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H50_RS01610	COG0477	Major facilitator Superfamily
I6H50_RS01620	COG3265	gluconokinase activity
I6H50_RS01625	COG2610	gluconate transmembrane transporter activity
I6H50_RS01650	COG3842	ATPase activity
I6H50_RS01690	COG0814	amino acid
I6H50_RS01700	COG1174	glycine betaine transport
I6H50_RS01730	COG1316	TRANSCRIPTIONal
I6H50_RS01770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H50_RS01785	COG0730	response to heat
I6H50_RS01790	COG1648	precorrin-2 dehydrogenase activity
I6H50_RS01790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H50_RS01800	COG1482	cell wall glycoprotein biosynthetic process
I6H50_RS01820	COG0745	RESPONSE REGULATOR receiver
I6H50_RS01825	COG5002	protein histidine kinase activity
I6H50_RS01830	COG5401	PFAM Sporulation and spore germination
I6H50_RS01840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H50_RS01845	COG0653	protein targeting
I6H50_RS01860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H50_RS01875	COG1162	GTPase activity
I6H50_RS01880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H50_RS01885	COG2135	peptidase activity
I6H50_RS01920	COG0513	Belongs to the DEAD box helicase family
I6H50_RS01945	COG0210	DNA helicase
I6H50_RS01950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H50_RS01980	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H50_RS02005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6H50_RS02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H50_RS02015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H50_RS02020	COG1120	ATPase activity
I6H50_RS02030	COG4762	Protein conserved in bacteria
I6H50_RS02050	COG0483	inositol monophosphate 1-phosphatase activity
I6H50_RS02055	COG0483	inositol monophosphate 1-phosphatase activity
I6H50_RS02060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H50_RS02065	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6H50_RS02070	COG2884	Cell division ATP-binding protein ftsE
I6H50_RS02075	COG2177	Part of the ABC transporter FtsEX involved in
I6H50_RS02145	COG1061	Type III restriction enzyme res subunit
I6H50_RS02160	COG1652	LysM domain
I6H50_RS02185	COG2252	PERMEase
I6H50_RS02190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H50_RS02210	COG0372	Belongs to the citrate synthase family
I6H50_RS02215	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H50_RS02230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H50_RS02240	COG3757	hydrolase, family 25
I6H50_RS02245	COG1765	OsmC-like protein
I6H50_RS02260	COG3340	Belongs to the peptidase S51 family
I6H50_RS02265	COG3328	transposase activity
I6H50_RS02320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H50_RS02330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H50_RS02335	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6H50_RS02340	COG1201	RNA secondary structure unwinding
I6H50_RS02345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H50_RS02350	COG3304	Inner membrane component domain
I6H50_RS02360	COG2056	Na+-H+ antiporter family
I6H50_RS02365	COG1605	Chorismate mutase
I6H50_RS02375	COG0739	heme binding
I6H50_RS02395	COG0138	bifunctional purine biosynthesis protein purh
I6H50_RS02410	COG1309	transcriptional regulator
I6H50_RS02425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H50_RS02430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H50_RS02435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H50_RS02440	COG0254	rRNA binding
I6H50_RS02450	COG0745	RESPONSE REGULATOR receiver
I6H50_RS02455	COG2205	protein histidine kinase activity
I6H50_RS02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H50_RS02465	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H50_RS02465	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H50_RS02475	COG1970	mechanosensitive ion channel activity
I6H50_RS02485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H50_RS02490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H50_RS02500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H50_RS02510	COG0519	Catalyzes the synthesis of GMP from XMP
I6H50_RS02525	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6H50_RS02535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H50_RS02555	COG0084	hydrolase, TatD family'
I6H50_RS02560	COG3583	domain protein
I6H50_RS02580	COG0488	(ABC) transporter
I6H50_RS02610	COG0561	phosphatase activity
I6H50_RS02615	COG1024	Enoyl-CoA hydratase
I6H50_RS02630	COG2409	Drug exporters of the RND superfamily
I6H50_RS02660	COG2985	domain, Protein
I6H50_RS02660	COG0569	domain protein
I6H50_RS02665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H50_RS02675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H50_RS02685	COG0193	aminoacyl-tRNA hydrolase activity
I6H50_RS02705	COG1131	(ABC) transporter
I6H50_RS02710	COG2197	response regulator
I6H50_RS02715	COG4585	Histidine kinase
I6H50_RS02720	COG2326	polyphosphate kinase activity
I6H50_RS02725	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H50_RS02730	COG0193	aminoacyl-tRNA hydrolase activity
I6H50_RS02740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H50_RS02745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H50_RS02755	COG2860	membrane
I6H50_RS02775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6H50_RS02780	COG0531	amino acid
I6H50_RS02785	COG3956	TIGRFAM MazG family protein
I6H50_RS02795	COG0148	phosphopyruvate hydratase activity
I6H50_RS02865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6H50_RS02880	COG1072	(Pantothenic acid kinase))
I6H50_RS02885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H50_RS02905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6H50_RS02925	COG0114	fumarate hydratase activity
I6H50_RS02930	COG1494	fructose-1,6-bisphosphatase
I6H50_RS02945	COG1722	exodeoxyribonuclease VII activity
I6H50_RS02965	COG1322	Protein conserved in bacteria
I6H50_RS02970	COG0628	permease
I6H50_RS02975	COG0012	GTP binding
I6H50_RS02980	COG0693	protein deglycase activity
I6H50_RS02985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H50_RS02990	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I6H50_RS02995	COG1823	symporter activity
I6H50_RS03000	COG1525	nuclease
I6H50_RS03010	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6H50_RS03015	COG0243	molybdopterin cofactor binding
I6H50_RS03015	COG3383	formate dehydrogenase (NAD+) activity
I6H50_RS03020	COG3383	formate dehydrogenase (NAD+) activity
I6H50_RS03020	COG0243	molybdopterin cofactor binding
I6H50_RS03025	COG0437	4 iron, 4 sulfur cluster binding
I6H50_RS03065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H50_RS03070	COG0428	transporter
I6H50_RS03075	COG2354	Protein conserved in bacteria
I6H50_RS03090	COG1217	gtp-binding protein TYPA
I6H50_RS03125	COG0564	pseudouridine synthase activity
I6H50_RS03140	COG1476	TRANSCRIPTIONal
I6H50_RS03150	COG2826	transposase and inactivated derivatives, IS30 family
I6H50_RS03155	COG1113	amino acid transport
I6H50_RS03165	COG1113	amino acid transport
I6H50_RS03170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H50_RS03175	COG1611	Belongs to the LOG family
I6H50_RS03180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H50_RS03185	COG0463	Glycosyl transferase, family 2
I6H50_RS03210	COG0297	glycogen (starch) synthase activity
I6H50_RS03215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H50_RS03220	COG4122	O-methyltransferase activity
I6H50_RS03225	COG1595	DNA-templated transcription, initiation
I6H50_RS03250	COG0567	Dehydrogenase, E1 component
I6H50_RS03250	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H50_RS03260	COG2272	Belongs to the type-B carboxylesterase lipase family
I6H50_RS03280	COG2814	Major facilitator Superfamily
I6H50_RS03285	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H50_RS03305	COG3314	Sporulation integral membrane protein YlbJ
I6H50_RS03315	COG0010	Belongs to the arginase family
I6H50_RS03325	COG2986	histidine ammonia-lyase
I6H50_RS03330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H50_RS03335	COG2755	lipolytic protein G-D-S-L family
I6H50_RS03340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6H50_RS03345	COG1228	amidohydrolase
I6H50_RS03375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H50_RS03380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H50_RS03415	COG1668	transmembrane transport
I6H50_RS03420	COG4152	abc transporter atp-binding protein
I6H50_RS03445	COG1556	Lactate utilization protein
I6H50_RS03450	COG1139	Iron-sulfur cluster binding protein
I6H50_RS03455	COG0247	lactate metabolic process
I6H50_RS03460	COG0018	arginyl-trna synthetase
I6H50_RS03465	COG0019	diaminopimelate decarboxylase activity
I6H50_RS03470	COG0460	homoserine dehydrogenase
I6H50_RS03475	COG0083	homoserine kinase activity
I6H50_RS03520	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H50_RS03530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H50_RS03535	COG0318	PFAM AMP-dependent synthetase and ligase
I6H50_RS03545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H50_RS03565	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H50_RS03570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H50_RS03575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H50_RS03580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H50_RS03585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H50_RS03595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H50_RS03600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H50_RS03610	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6H50_RS03625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H50_RS03635	COG0366	Alpha amylase catalytic
I6H50_RS03640	COG1119	ATPase activity
I6H50_RS03660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6H50_RS03685	COG0482	sulfurtransferase activity
I6H50_RS03705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H50_RS03720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H50_RS03730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H50_RS03755	COG0205	6-phosphofructokinase activity
I6H50_RS03760	COG0385	Bile acid
I6H50_RS03775	COG1064	alcohol dehydrogenase
I6H50_RS03780	COG3949	Membrane
I6H50_RS03785	COG0667	Aldo Keto reductase
I6H50_RS03795	COG0583	DNA-binding transcription factor activity
I6H50_RS03820	COG0129	dihydroxy-acid dehydratase activity
I6H50_RS03830	COG0028	Belongs to the TPP enzyme family
I6H50_RS03835	COG0440	acetolactate synthase activity
I6H50_RS03840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H50_RS03865	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H50_RS03890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H50_RS03895	COG1121	(ABC) transporter
I6H50_RS03905	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H50_RS03960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H50_RS03965	COG0066	3-isopropylmalate dehydratase activity
I6H50_RS03975	COG0406	alpha-ribazole phosphatase activity
I6H50_RS03975	COG0494	nUDIX hydrolase
I6H50_RS03980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H50_RS03985	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H50_RS03995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6H50_RS04000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H50_RS04005	COG1461	Dihydroxyacetone kinase
I6H50_RS04010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H50_RS04015	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H50_RS04020	COG0742	ribosomal rna small subunit methyltransferase
I6H50_RS04025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H50_RS04040	COG0765	amino acid transport
I6H50_RS04045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H50_RS04055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H50_RS04085	COG2226	methyltransferase
I6H50_RS04090	COG0539	negative regulation of cytoplasmic translation
I6H50_RS04100	COG0237	dephospho-CoA kinase activity
I6H50_RS04130	COG3973	AAA domain
I6H50_RS04160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H50_RS04165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H50_RS04175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H50_RS04185	COG0072	phenylalanine-tRNA ligase activity
I6H50_RS04185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H50_RS04190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6H50_RS04205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H50_RS04210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H50_RS04215	COG1438	arginine binding
I6H50_RS04220	COG0137	argininosuccinate synthase activity
I6H50_RS04225	COG0165	Argininosuccinate lyase
I6H50_RS04240	COG2835	tetraacyldisaccharide 4'-kinase activity
I6H50_RS04280	COG0647	UMP catabolic process
I6H50_RS04295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H50_RS04315	COG0494	nUDIX hydrolase
I6H50_RS04320	COG4974	Belongs to the 'phage' integrase family
I6H50_RS04345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H50_RS04355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H50_RS04360	COG1160	GTP binding
I6H50_RS04365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H50_RS04375	COG1132	(ABC) transporter
I6H50_RS04380	COG1132	(ABC) transporter
I6H50_RS04405	COG4584	PFAM Integrase catalytic
I6H50_RS04415	COG2197	response regulator
I6H50_RS04440	COG1131	(ABC) transporter
I6H50_RS04455	COG3012	SEC-C Motif Domain Protein
I6H50_RS04465	COG0653	protein targeting
I6H50_RS04470	COG1716	ATPase activity
I6H50_RS04500	COG0513	Belongs to the DEAD box helicase family
I6H50_RS04505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H50_RS04515	COG3268	Saccharopine dehydrogenase
I6H50_RS04520	COG0598	Magnesium transport protein CorA
I6H50_RS04530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H50_RS04530	COG0351	phosphomethylpyrimidine kinase
I6H50_RS04530	COG0352	thiamine-phosphate diphosphorylase activity
I6H50_RS04535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H50_RS04535	COG0352	thiamine-phosphate diphosphorylase activity
I6H50_RS04535	COG0351	phosphomethylpyrimidine kinase
I6H50_RS04555	COG2837	iron assimilation
I6H50_RS04575	COG0463	Glycosyl transferase, family 2
I6H50_RS04595	COG0300	oxidoreductase activity
I6H50_RS04610	COG0805	protein transport
I6H50_RS04615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H50_RS04630	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6H50_RS04640	COG4122	O-methyltransferase activity
I6H50_RS04645	COG1222	aaa ATPase
I6H50_RS04655	COG1362	aminopeptidase activity
I6H50_RS04675	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H50_RS04680	COG2826	transposase and inactivated derivatives, IS30 family
I6H50_RS04685	COG1027	Aspartate ammonia-lyase
I6H50_RS04690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6H50_RS04710	COG0215	cysteine-tRNA ligase activity
I6H50_RS04725	COG0167	dihydroorotate dehydrogenase activity
I6H50_RS04735	COG1881	PFAM PEBP family protein
I6H50_RS04765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H50_RS04770	COG3883	PFAM NLP P60 protein
I6H50_RS04770	COG0791	NLP P60 protein
I6H50_RS04780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H50_RS04815	COG3830	Belongs to the UPF0237 family
I6H50_RS04820	COG2848	UPF0210 protein
I6H50_RS04830	COG0488	(ABC) transporter
I6H50_RS04835	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H50_RS04840	COG0822	iron-sulfur transferase activity
I6H50_RS04850	COG0396	ATPase activity
I6H50_RS04905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H50_RS04925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H50_RS04930	COG0149	triose-phosphate isomerase activity
I6H50_RS04935	COG0126	phosphoglycerate kinase activity
I6H50_RS04940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H50_RS04945	COG1620	l-lactate permease
I6H50_RS04950	COG1481	regulation of sporulation
I6H50_RS04955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6H50_RS04960	COG1660	Displays ATPase and GTPase activities
I6H50_RS04965	COG0322	excinuclease ABC activity
I6H50_RS04975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H50_RS05005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H50_RS05010	COG0242	peptide deformylase activity
I6H50_RS05020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H50_RS05030	COG1758	RNA polymerase activity
I6H50_RS05045	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H50_RS05050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H50_RS05060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H50_RS05065	COG0540	Belongs to the ATCase OTCase family
I6H50_RS05100	COG2326	polyphosphate kinase activity
I6H50_RS05105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H50_RS05110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H50_RS05120	COG0006	proline dipeptidase activity
I6H50_RS05125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H50_RS05135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H50_RS05140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H50_RS05150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H50_RS05160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H50_RS05180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H50_RS05200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H50_RS05210	COG1760	l-serine dehydratase
I6H50_RS05220	COG0124	histidyl-tRNA synthetase
I6H50_RS05225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H50_RS05230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H50_RS05235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H50_RS05255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H50_RS05265	COG0747	negative chemotaxis
I6H50_RS05270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H50_RS05275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H50_RS05285	COG2255	four-way junction helicase activity
I6H50_RS05290	COG0632	four-way junction helicase activity
I6H50_RS05295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H50_RS05300	COG0217	transcriptional regulatory protein
I6H50_RS05305	COG1946	Acyl-CoA thioesterase
I6H50_RS05320	COG0438	transferase activity, transferring glycosyl groups
I6H50_RS05325	COG1560	Kdo2-lipid A biosynthetic process
I6H50_RS05330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H50_RS05340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H50_RS05345	COG2837	iron assimilation
I6H50_RS05415	COG3253	May function as heme-dependent peroxidase
I6H50_RS05425	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6H50_RS05430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6H50_RS05435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H50_RS05465	COG0483	inositol monophosphate 1-phosphatase activity
I6H50_RS05495	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H50_RS05505	COG0814	amino acid
I6H50_RS05510	COG1760	l-serine dehydratase
I6H50_RS05525	COG1321	iron dependent repressor
I6H50_RS05530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H50_RS05550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H50_RS05555	COG0450	alkyl hydroperoxide reductase
I6H50_RS05570	COG1643	Atp-dependent helicase
I6H50_RS05575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H50_RS05580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H50_RS05585	COG1349	DNA-binding transcription factor activity
I6H50_RS05590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H50_RS05600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H50_RS05600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H50_RS05600	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6H50_RS05605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H50_RS05615	COG2233	PERMEase
I6H50_RS05620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H50_RS05635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H50_RS05640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H50_RS05650	COG1196	nuclear chromosome segregation
I6H50_RS05670	COG2137	regulation of response to DNA damage stimulus
I6H50_RS05675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H50_RS05685	COG1268	BioY protein
I6H50_RS05690	COG1122	ATPase activity
I6H50_RS05695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H50_RS05700	COG1842	Phage shock protein A
I6H50_RS05705	COG1396	sequence-specific DNA binding
I6H50_RS05730	COG1674	ftsk spoiiie
I6H50_RS05740	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6H50_RS05745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H50_RS05750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6H50_RS05755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H50_RS05770	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H50_RS05775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H50_RS05790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H50_RS05795	COG2977	Belongs to the P-Pant transferase superfamily
I6H50_RS05800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H50_RS05810	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H50_RS05815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H50_RS05830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H50_RS05845	COG0779	Required for maturation of 30S ribosomal subunits
I6H50_RS05865	COG0442	prolyl-tRNA aminoacylation
I6H50_RS05870	COG3022	response to hydroperoxide
I6H50_RS05885	COG1131	(ABC) transporter
I6H50_RS05890	COG2197	response regulator
I6H50_RS05895	COG4585	Histidine kinase
I6H50_RS05900	COG0384	phenazine biosynthesis protein PhzF
I6H50_RS05905	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6H50_RS05910	COG0579	oxidoreductase
I6H50_RS05940	COG0768	penicillin binding
I6H50_RS05945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H50_RS05955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6H50_RS05990	COG0233	cytoplasmic translational termination
I6H50_RS06000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H50_RS06005	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H50_RS06015	COG4974	Belongs to the 'phage' integrase family
I6H50_RS06040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H50_RS06050	COG0681	Belongs to the peptidase S26 family
I6H50_RS06055	COG0335	large ribosomal subunit rRNA binding
I6H50_RS06075	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H50_RS06085	COG2826	transposase and inactivated derivatives, IS30 family
I6H50_RS06135	COG1309	transcriptional regulator
I6H50_RS06145	COG3328	transposase activity
I6H50_RS06155	COG0228	four-way junction DNA binding
I6H50_RS06160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H50_RS06160	COG2755	lipolytic protein G-D-S-L family
I6H50_RS06170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6H50_RS06195	COG0651	ATP synthesis coupled electron transport
I6H50_RS06200	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H50_RS06205	COG2111	Na H antiporter
I6H50_RS06205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H50_RS06220	COG1254	Belongs to the acylphosphatase family
I6H50_RS06225	COG1115	amino acid carrier protein
I6H50_RS06230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H50_RS06235	COG0571	ribonuclease III activity
I6H50_RS06255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H50_RS06260	COG1929	Belongs to the glycerate kinase type-1 family
I6H50_RS06275	COG0058	SHG alpha-glucan phosphorylase activity
I6H50_RS06300	COG0469	pyruvate kinase activity
I6H50_RS06305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H50_RS06325	COG0107	imidazoleglycerol-phosphate synthase activity
I6H50_RS06330	COG0483	inositol monophosphate 1-phosphatase activity
I6H50_RS06340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6H50_RS06355	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H50_RS06360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H50_RS06365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H50_RS06395	COG2176	DNA-directed DNA polymerase activity
I6H50_RS06420	COG1739	Uncharacterized protein family UPF0029
I6H50_RS06425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H50_RS06440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H50_RS06475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H50_RS06490	COG0252	asparaginase activity
I6H50_RS06515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H50_RS06530	COG3599	regulation of cell shape
I6H50_RS06540	COG1799	cell septum assembly
I6H50_RS06545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H50_RS06550	COG1496	oxidoreductase activity
I6H50_RS06555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H50_RS06565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H50_RS06570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H50_RS06585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H50_RS06595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H50_RS06600	COG0768	penicillin binding
I6H50_RS06610	COG0275	rRNA processing
I6H50_RS06635	COG0142	geranyltranstransferase activity
I6H50_RS06655	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6H50_RS06680	COG1940	carbohydrate kinase activity
I6H50_RS06685	COG0438	transferase activity, transferring glycosyl groups
I6H50_RS06705	COG0723	plastoquinol--plastocyanin reductase activity
I6H50_RS06715	COG1845	cytochrome c oxidase, subunit III
I6H50_RS06745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6H50_RS06750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H50_RS06760	COG1335	isochorismatase
I6H50_RS06775	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H50_RS06780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H50_RS06780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H50_RS06785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6H50_RS06790	COG0509	glycine decarboxylation via glycine cleavage system
I6H50_RS06795	COG0321	lipoyl(octanoyl) transferase activity
I6H50_RS06800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H50_RS06815	COG0174	glutamine synthetase
I6H50_RS06855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H50_RS06885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6H50_RS06890	COG0174	glutamine synthetase
I6H50_RS06915	COG0557	exoribonuclease II activity
I6H50_RS06935	COG3323	Protein of unknown function (DUF1653)
I6H50_RS06935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H50_RS06970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6H50_RS06975	COG2267	carboxylic ester hydrolase activity
I6H50_RS06980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H50_RS07005	COG1902	pentaerythritol trinitrate reductase activity
I6H50_RS07010	COG0668	transmembrane transport
I6H50_RS07020	COG2860	membrane
I6H50_RS07060	COG1846	Transcriptional regulator
I6H50_RS07065	COG1764	response to oxidative stress
I6H50_RS07070	COG1764	response to oxidative stress
I6H50_RS07085	COG4988	ABC transporter
I6H50_RS07185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H50_RS07190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H50_RS07200	COG1215	transferase activity, transferring glycosyl groups
I6H50_RS07245	COG1682	transport, permease protein
I6H50_RS07250	COG1134	teichoic acid transport
I6H50_RS07265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6H50_RS07280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6H50_RS07340	COG0423	glycine-tRNA ligase activity
I6H50_RS07355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H50_RS07360	COG1381	Involved in DNA repair and RecF pathway recombination
I6H50_RS07375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H50_RS07390	COG0484	heat shock protein binding
I6H50_RS07395	COG1420	regulation of RNA biosynthetic process
I6H50_RS07405	COG1253	flavin adenine dinucleotide binding
I6H50_RS07410	COG1253	flavin adenine dinucleotide binding
I6H50_RS07455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6H50_RS07465	COG1132	(ABC) transporter
I6H50_RS07475	COG1114	Component of the transport system for branched-chain amino acids
I6H50_RS07480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H50_RS07490	COG2186	Transcriptional regulator
I6H50_RS07495	COG0747	negative chemotaxis
I6H50_RS07500	COG0601	transmembrane transport
I6H50_RS07505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H50_RS07510	COG4172	Belongs to the ABC transporter superfamily
I6H50_RS07525	COG2391	methyltransferase activity
I6H50_RS07535	COG2197	response regulator
I6H50_RS07540	COG4585	Histidine kinase
I6H50_RS07545	COG2197	response regulator
I6H50_RS07555	COG4585	Histidine kinase
I6H50_RS07560	COG1473	amidohydrolase
I6H50_RS07585	COG0481	GTPase activity
I6H50_RS07595	COG0268	Binds directly to 16S ribosomal RNA
I6H50_RS07615	COG1280	lysine exporter protein (LysE YggA)
I6H50_RS07640	COG1307	EDD domain protein, DegV family
I6H50_RS07650	COG0799	negative regulation of ribosome biogenesis
I6H50_RS07655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H50_RS07670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H50_RS07710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H50_RS07715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H50_RS07720	COG1530	ribonuclease E activity
I6H50_RS07730	COG0798	PFAM Bile acid sodium symporter
I6H50_RS07735	COG0640	Transcriptional regulator
I6H50_RS07740	COG0105	UTP biosynthetic process
I6H50_RS07755	COG0285	dihydrofolate synthase activity
I6H50_RS07765	COG0039	L-malate dehydrogenase activity
I6H50_RS07775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H50_RS07780	COG1028	Short-chain dehydrogenase reductase Sdr
I6H50_RS07800	COG3104	oligopeptide transport
I6H50_RS07805	COG0740	serine-type endopeptidase activity
I6H50_RS07820	COG1780	Probably involved in ribonucleotide reductase function
I6H50_RS07825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H50_RS07830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H50_RS07840	COG0431	NADPH-dependent FMN reductase
I6H50_RS07845	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H50_RS07865	COG0778	Nitroreductase
I6H50_RS07890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6H50_RS07900	COG2186	Transcriptional regulator
I6H50_RS07905	COG4221	oxidoreductase activity
I6H50_RS07920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H50_RS07945	COG0668	transmembrane transport
I6H50_RS07955	COG0686	Belongs to the AlaDH PNT family
I6H50_RS07985	COG0583	DNA-binding transcription factor activity
I6H50_RS07995	COG4221	oxidoreductase activity
I6H50_RS08000	COG1115	amino acid carrier protein
I6H50_RS08015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H50_RS08020	COG1376	ErfK ybiS ycfS ynhG family protein
I6H50_RS08030	COG1120	ATPase activity
I6H50_RS08035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H50_RS08045	COG2066	Belongs to the glutaminase family
I6H50_RS08075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H50_RS08080	COG3104	oligopeptide transport
I6H50_RS08105	COG1882	Formate acetyltransferase
I6H50_RS08110	COG2233	PERMEase
I6H50_RS08140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6H50_RS08145	COG1234	tRNA 3'-trailer cleavage
I6H50_RS08160	COG3191	aminopeptidase activity
I6H50_RS08170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6H50_RS08175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H50_RS08190	COG3830	Belongs to the UPF0237 family
I6H50_RS08190	COG0560	Phosphoserine phosphatase
I6H50_RS08195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H50_RS08200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H50_RS08210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H50_RS08230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H50_RS08235	COG2814	Major facilitator Superfamily
I6H50_RS08240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H50_RS08255	COG3634	alkyl hydroperoxide reductase activity
I6H50_RS08275	COG0033	Phosphoglucomutase
I6H50_RS08280	COG1115	amino acid carrier protein
I6H50_RS08285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H50_RS08290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H50_RS08295	COG0577	efflux transmembrane transporter activity
I6H50_RS08300	COG1136	(ABC) transporter
I6H50_RS08300	COG0577	efflux transmembrane transporter activity
I6H50_RS08330	COG2197	response regulator
I6H50_RS08335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H50_RS08340	COG1045	serine acetyltransferase
I6H50_RS08375	COG1937	Protein conserved in bacteria
I6H50_RS08400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H50_RS08420	COG0456	acetyltransferase
I6H50_RS08430	COG1597	lipid kinase activity
I6H50_RS08455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H50_RS08475	COG0252	asparaginase activity
I6H50_RS08495	COG4584	PFAM Integrase catalytic
I6H50_RS08505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H50_RS08520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H50_RS08530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H50_RS08560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H50_RS08575	COG2205	protein histidine kinase activity
I6H50_RS08580	COG0745	RESPONSE REGULATOR receiver
I6H50_RS08585	COG0028	Belongs to the TPP enzyme family
I6H50_RS08590	COG0477	Major facilitator Superfamily
I6H50_RS08595	COG1309	transcriptional regulator
I6H50_RS08615	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6H50_RS08630	COG1609	Transcriptional regulator
I6H50_RS08635	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H50_RS08640	COG3842	ATPase activity
I6H50_RS08645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H50_RS08660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H50_RS08685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H50_RS08695	COG2847	Copper chaperone PCu(A)C
I6H50_RS08700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H50_RS08715	COG1194	a g-specific adenine glycosylase
I6H50_RS08725	COG0542	response to heat
I6H50_RS08735	COG2814	Major facilitator Superfamily
I6H50_RS08755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H50_RS08765	COG1966	Carbon starvation protein
I6H50_RS08775	COG0003	Pfam Anion-transporting ATPase
I6H50_RS08780	COG3579	cysteine-type endopeptidase activity
I6H50_RS08785	COG3579	cysteine-type endopeptidase activity
I6H50_RS08795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H50_RS08830	COG0302	gtp cyclohydrolase
I6H50_RS08835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H50_RS08845	COG0037	tRNA processing
I6H50_RS08850	COG2027	D-alanyl-D-alanine carboxypeptidase
I6H50_RS08855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6H50_RS08865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H50_RS08875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H50_RS08890	COG2326	polyphosphate kinase activity
I6H50_RS08900	COG0459	protein refolding
I6H50_RS08905	COG1297	OPT oligopeptide transporter protein
I6H50_RS08915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H50_RS08915	COG2111	Na H antiporter
I6H50_RS08920	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H50_RS08925	COG0651	ATP synthesis coupled electron transport
I6H50_RS08935	COG2212	antiporter activity
I6H50_RS08940	COG1320	monovalent cation:proton antiporter activity
I6H50_RS08945	COG1051	belongs to the nudix hydrolase family
I6H50_RS08965	COG0242	peptide deformylase activity
I6H50_RS08990	COG1131	(ABC) transporter
I6H50_RS09005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H50_RS09020	COG3311	Transcriptional regulator
I6H50_RS09025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H50_RS09030	COG0280	phosphate acetyltransferase
I6H50_RS09040	COG2153	protein acetylation
I6H50_RS09065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H50_RS09075	COG4129	membrane
I6H50_RS09085	COG0191	fructose-bisphosphate aldolase activity
I6H50_RS09100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H50_RS09110	COG2897	thiosulfate sulfurtransferase activity
I6H50_RS09150	COG0789	Transcriptional regulator
I6H50_RS09165	COG0443	Heat shock 70 kDa protein
I6H50_RS09180	COG0745	RESPONSE REGULATOR receiver
I6H50_RS09185	COG1012	belongs to the aldehyde dehydrogenase family
I6H50_RS09195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H50_RS09210	COG4584	PFAM Integrase catalytic
I6H50_RS09245	COG0175	sulfate reduction
I6H50_RS09280	COG0247	lactate metabolic process
I6H50_RS09280	COG2181	nitrate reductase activity
I6H50_RS09305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6H50_RS09350	COG1132	(ABC) transporter
I6H50_RS09360	COG1472	Belongs to the glycosyl hydrolase 3 family
I6H50_RS09375	COG4981	capsule polysaccharide biosynthetic process
I6H50_RS09400	COG0500	methyltransferase
I6H50_RS09410	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6H50_RS09415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H50_RS09440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H50_RS09445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H50_RS09445	COG3321	synthase
I6H50_RS09445	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6H50_RS09450	COG0318	PFAM AMP-dependent synthetase and ligase
I6H50_RS09455	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6H50_RS09465	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H50_RS09465	COG5479	isomerase activity
I6H50_RS09470	COG1012	belongs to the aldehyde dehydrogenase family
I6H50_RS09485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6H50_RS09490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6H50_RS09500	COG1216	Glycosyl transferase, family 2
I6H50_RS09540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6H50_RS09545	COG0732	type I restriction modification DNA specificity domain
I6H50_RS09550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6H50_RS09570	COG0561	phosphatase activity
I6H50_RS09575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H50_RS09580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H50_RS09585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6H50_RS09595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H50_RS09600	COG2188	Transcriptional regulator
I6H50_RS09620	COG0077	Prephenate dehydratase
I6H50_RS09635	COG1316	TRANSCRIPTIONal
I6H50_RS09660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H50_RS09675	COG2814	Major facilitator Superfamily
I6H50_RS09700	COG2197	response regulator
I6H50_RS09705	COG4585	Histidine kinase
I6H50_RS09720	COG3764	Sortase (surface protein transpeptidase)
I6H50_RS09725	COG0706	membrane insertase activity
I6H50_RS09750	COG0564	pseudouridine synthase activity
I6H50_RS09775	COG1131	(ABC) transporter
I6H50_RS09790	COG1842	Phage shock protein A
I6H50_RS09795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H50_RS09810	COG0477	Major facilitator Superfamily
I6H50_RS09820	COG0305	Participates in initiation and elongation during chromosome replication
I6H50_RS09825	COG0359	binds to the 23S rRNA
I6H50_RS09830	COG0629	single-stranded DNA binding
I6H50_RS09835	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H50_RS09850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H50_RS09860	COG1260	myo-inositol-1-phosphate synthase
I6H50_RS09865	COG1846	Transcriptional regulator
I6H50_RS09890	COG1054	Belongs to the UPF0176 family
I6H50_RS09895	COG4868	Belongs to the UPF0371 family
I6H50_RS09900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H50_RS09905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H50_RS09905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H50_RS09910	COG0577	efflux transmembrane transporter activity
I6H50_RS09910	COG1136	(ABC) transporter
I6H50_RS09915	COG0577	efflux transmembrane transporter activity
I6H50_RS09920	COG4585	Histidine kinase
I6H50_RS09925	COG2197	response regulator
I6H50_RS09930	COG2072	flavoprotein involved in K transport
I6H50_RS09945	COG0604	alcohol dehydrogenase
I6H50_RS09960	COG0495	leucyl-tRNA aminoacylation
I6H50_RS09985	COG3547	Transposase (IS116 IS110 IS902 family)
I6H50_RS09990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H50_RS09995	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H50_RS10000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H50_RS10005	COG0135	phosphoribosylanthranilate isomerase activity
I6H50_RS10005	COG0134	indole-3-glycerol-phosphate synthase activity
I6H50_RS10015	COG0159	tryptophan synthase activity
I6H50_RS10060	COG1678	Uncharacterized ACR, COG1678
I6H50_RS10065	COG0617	tRNA 3'-terminal CCA addition
I6H50_RS10115	COG0789	Transcriptional regulator
I6H50_RS10135	COG0789	Transcriptional regulator
I6H50_RS10140	COG0659	secondary active sulfate transmembrane transporter activity
I6H50_RS10150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H50_RS10155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H50_RS10190	COG3118	belongs to the thioredoxin family
I6H50_RS10195	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H50_RS10195	COG3409	Peptidoglycan-binding domain 1 protein
I6H50_RS10210	COG1192	Involved in chromosome partitioning
I6H50_RS10225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H50_RS10230	COG0594	ribonuclease P activity
I6H50_RS10235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H50_RS10240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H50_RS10245	COG0592	DNA-directed DNA polymerase activity
I6H50_RS10250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H50_RS10260	COG0187	DNA topoisomerase II activity
I6H50_RS10290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H50_RS10310	COG2315	Protein conserved in bacteria
I6H50_RS10320	COG2094	Belongs to the DNA glycosylase MPG family
I6H50_RS10325	COG0726	polysaccharide deacetylase
I6H50_RS10360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H50_RS10400	COG0515	serine threonine protein kinase
I6H50_RS10400	COG2815	serine threonine protein kinase
I6H50_RS10405	COG0515	serine threonine protein kinase
I6H50_RS10410	COG0768	penicillin binding
I6H50_RS10430	COG1716	ATPase activity
I6H50_RS10430	COG1716	ATPase activity
I6H50_RS10460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H50_RS10465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6H50_RS10485	COG4584	PFAM Integrase catalytic
I6H50_RS10515	COG2132	Multicopper oxidase
I6H50_RS10525	COG0745	RESPONSE REGULATOR receiver
I6H50_RS10530	COG2205	protein histidine kinase activity
I6H50_RS10540	COG2217	Heavy metal translocating P-type atpase
I6H50_RS10590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H50_RS10595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H50_RS10605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H50_RS10620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H50_RS10630	COG0659	secondary active sulfate transmembrane transporter activity
I6H50_RS10665	COG3180	Ammonia monooxygenase
I6H50_RS10670	COG0730	response to heat
I6H50_RS10675	COG1643	Atp-dependent helicase
I6H50_RS10680	COG0110	maltose O-acetyltransferase activity
I6H50_RS10690	COG0431	NADPH-dependent FMN reductase
I6H50_RS10700	COG1012	belongs to the aldehyde dehydrogenase family
I6H50_RS10705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H50_RS10745	COG0393	Putative heavy-metal-binding
I6H50_RS10755	COG2501	S4 domain
I6H50_RS10765	COG3695	enzyme binding
I6H50_RS10770	COG2076	Multidrug Resistance protein
I6H50_RS10790	COG3590	peptidase
I6H50_RS10820	COG0277	FAD linked oxidase domain protein
I6H50_RS10850	COG1216	Glycosyl transferase, family 2
I6H50_RS10875	COG3321	synthase
I6H50_RS10875	COG0604	alcohol dehydrogenase
I6H50_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
I6H50_RS10885	COG2188	Transcriptional regulator
I6H50_RS10910	COG3842	ATPase activity
I6H50_RS10925	COG0314	molybdopterin synthase activity
I6H50_RS10930	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H50_RS10985	COG2239	Acts as a magnesium transporter
I6H50_RS10990	COG0471	metal ion transport
I6H50_RS10995	COG0523	cobalamin synthesis protein
I6H50_RS11005	COG2826	transposase and inactivated derivatives, IS30 family
I6H50_RS11025	COG0287	Prephenate dehydrogenase
I6H50_RS11035	COG0590	tRNA wobble adenosine to inosine editing
I6H50_RS11050	COG2409	Drug exporters of the RND superfamily
I6H50_RS11055	COG0343	queuine tRNA-ribosyltransferase activity
I6H50_RS11065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H50_RS11090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H50_RS11120	COG3442	glutamine amidotransferase
I6H50_RS11125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H50_RS11145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H50_RS11155	COG0697	spore germination
I6H50_RS11160	COG0527	aspartate kinase activity
I6H50_RS11170	COG3949	Membrane
I6H50_RS11175	COG3547	Transposase (IS116 IS110 IS902 family)
I6H50_RS11250	COG0251	oxidation-reduction process
I6H50_RS11255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H50_RS11260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H50_RS11270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H50_RS11275	COG0494	nUDIX hydrolase
I6H50_RS11285	COG0596	Alpha beta hydrolase
I6H50_RS11345	COG1111	helicase
I6H50_RS11345	COG1205	dead DEAH box helicase
I6H50_RS11350	COG1278	Cold shock
I6H50_RS11360	COG1754	DNA topoisomerase type I activity
I6H50_RS11360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H50_RS11370	COG2311	Membrane
I6H50_RS11380	COG0470	DNA polymerase III
I6H50_RS11390	COG0318	PFAM AMP-dependent synthetase and ligase
I6H50_RS11405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H50_RS11420	COG1088	dTDP-glucose 4,6-dehydratase activity