locus-tag	class	description
CULFRC58_RS00010	COG0592	DNA-directed DNA polymerase activity
CULFRC58_RS00025	COG0187	DNA topoisomerase II activity
CULFRC58_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CULFRC58_RS00140	COG1518	maintenance of DNA repeat elements
CULFRC58_RS00185	COG1120	ATPase activity
CULFRC58_RS00190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS00195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS00200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CULFRC58_RS00210	COG2815	serine threonine protein kinase
CULFRC58_RS00210	COG0515	serine threonine protein kinase
CULFRC58_RS00215	COG0515	serine threonine protein kinase
CULFRC58_RS00220	COG0768	penicillin binding
CULFRC58_RS00240	COG1716	ATPase activity
CULFRC58_RS00240	COG1716	ATPase activity
CULFRC58_RS00275	COG2897	thiosulfate sulfurtransferase activity
CULFRC58_RS00295	COG1120	ATPase activity
CULFRC58_RS00300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS00305	COG2239	Acts as a magnesium transporter
CULFRC58_RS00310	COG0366	Alpha amylase catalytic
CULFRC58_RS00320	COG1131	(ABC) transporter
CULFRC58_RS00330	COG2197	response regulator
CULFRC58_RS00385	COG0517	IMP dehydrogenase activity
CULFRC58_RS00385	COG1125	glycine betaine transport
CULFRC58_RS00395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULFRC58_RS00415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CULFRC58_RS00435	COG3757	hydrolase, family 25
CULFRC58_RS00435	COG3409	Peptidoglycan-binding domain 1 protein
CULFRC58_RS00455	COG0477	Major facilitator Superfamily
CULFRC58_RS00510	COG1201	RNA secondary structure unwinding
CULFRC58_RS00535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CULFRC58_RS00560	COG1846	Transcriptional regulator
CULFRC58_RS00575	COG3180	Ammonia monooxygenase
CULFRC58_RS00585	COG0730	response to heat
CULFRC58_RS00595	COG3037	sugar-specific permease SgaT UlaA
CULFRC58_RS00600	COG1643	Atp-dependent helicase
CULFRC58_RS00605	COG0110	maltose O-acetyltransferase activity
CULFRC58_RS00615	COG0519	Catalyzes the synthesis of GMP from XMP
CULFRC58_RS00625	COG1280	lysine exporter protein (LysE YggA)
CULFRC58_RS00630	COG0393	Putative heavy-metal-binding
CULFRC58_RS00635	COG2501	S4 domain
CULFRC58_RS00655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CULFRC58_RS00660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CULFRC58_RS00670	COG3590	peptidase
CULFRC58_RS00700	COG1028	Short-chain dehydrogenase reductase Sdr
CULFRC58_RS00705	COG0277	FAD linked oxidase domain protein
CULFRC58_RS00735	COG1216	Glycosyl transferase, family 2
CULFRC58_RS00740	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULFRC58_RS00745	COG1121	(ABC) transporter
CULFRC58_RS00750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULFRC58_RS00755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULFRC58_RS00760	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULFRC58_RS00785	COG0604	alcohol dehydrogenase
CULFRC58_RS00815	COG0471	metal ion transport
CULFRC58_RS00825	COG1263	PTS System
CULFRC58_RS00825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CULFRC58_RS00830	COG2190	(PTS) system
CULFRC58_RS00830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CULFRC58_RS00830	COG1263	PTS System
CULFRC58_RS00870	COG2963	transposase activity
CULFRC58_RS00875	COG2801	Transposase and inactivated derivatives
CULFRC58_RS00895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CULFRC58_RS00915	COG0287	Prephenate dehydrogenase
CULFRC58_RS00935	COG2409	Drug exporters of the RND superfamily
CULFRC58_RS00940	COG0343	queuine tRNA-ribosyltransferase activity
CULFRC58_RS00950	COG2610	gluconate transmembrane transporter activity
CULFRC58_RS00955	COG3265	gluconokinase activity
CULFRC58_RS00960	COG1063	alcohol dehydrogenase
CULFRC58_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
CULFRC58_RS00975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CULFRC58_RS01000	COG2610	gluconate transmembrane transporter activity
CULFRC58_RS01005	COG2084	Dehydrogenase
CULFRC58_RS01015	COG2186	Transcriptional regulator
CULFRC58_RS01020	COG0179	Fumarylacetoacetate (FAA) hydrolase
CULFRC58_RS01030	COG3442	glutamine amidotransferase
CULFRC58_RS01035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CULFRC58_RS01050	COG0778	Nitroreductase
CULFRC58_RS01060	COG2390	Transcriptional regulator
CULFRC58_RS01065	COG0813	purine-nucleoside phosphorylase activity
CULFRC58_RS01070	COG2814	Major facilitator Superfamily
CULFRC58_RS01080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CULFRC58_RS01090	COG3266	domain, Protein
CULFRC58_RS01090	COG4932	domain protein
CULFRC58_RS01090	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CULFRC58_RS01100	COG0697	spore germination
CULFRC58_RS01105	COG1131	(ABC) transporter
CULFRC58_RS01115	COG0527	aspartate kinase activity
CULFRC58_RS01125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CULFRC58_RS01175	COG1840	ABC-type Fe3 transport system, periplasmic component
CULFRC58_RS01180	COG2271	Major facilitator Superfamily
CULFRC58_RS01190	COG3852	Histidine kinase
CULFRC58_RS01210	COG0651	ATP synthesis coupled electron transport
CULFRC58_RS01220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CULFRC58_RS01220	COG2111	Na H antiporter
CULFRC58_RS01250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CULFRC58_RS01270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CULFRC58_RS01290	COG0494	nUDIX hydrolase
CULFRC58_RS01360	COG1205	dead DEAH box helicase
CULFRC58_RS01360	COG1111	helicase
CULFRC58_RS01370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CULFRC58_RS01370	COG1754	DNA topoisomerase type I activity
CULFRC58_RS01375	COG1297	OPT oligopeptide transporter protein
CULFRC58_RS01385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CULFRC58_RS01395	COG4974	Belongs to the 'phage' integrase family
CULFRC58_RS01615	COG0318	PFAM AMP-dependent synthetase and ligase
CULFRC58_RS01635	COG1088	dTDP-glucose 4,6-dehydratase activity
CULFRC58_RS01645	COG1505	serine-type exopeptidase activity
CULFRC58_RS01655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CULFRC58_RS01660	COG3800	Transcriptional regulator
CULFRC58_RS01660	COG1396	sequence-specific DNA binding
CULFRC58_RS01670	COG1053	succinate dehydrogenase
CULFRC58_RS01675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CULFRC58_RS01685	COG2733	membrane
CULFRC58_RS01695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CULFRC58_RS01705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CULFRC58_RS01715	COG1882	Formate acetyltransferase
CULFRC58_RS01735	COG0318	PFAM AMP-dependent synthetase and ligase
CULFRC58_RS01750	COG5002	protein histidine kinase activity
CULFRC58_RS01755	COG0745	RESPONSE REGULATOR receiver
CULFRC58_RS01775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CULFRC58_RS01785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CULFRC58_RS01785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CULFRC58_RS01815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CULFRC58_RS01815	COG1648	precorrin-2 dehydrogenase activity
CULFRC58_RS01830	COG2217	Heavy metal translocating P-type atpase
CULFRC58_RS01840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CULFRC58_RS01855	COG0406	alpha-ribazole phosphatase activity
CULFRC58_RS01865	COG0785	Cytochrome C biogenesis protein
CULFRC58_RS01880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CULFRC58_RS01910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CULFRC58_RS01920	COG3069	C4-dicarboxylate transmembrane transporter activity
CULFRC58_RS01925	COG4948	Mandelate Racemase Muconate Lactonizing
CULFRC58_RS01940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CULFRC58_RS01940	COG0438	transferase activity, transferring glycosyl groups
CULFRC58_RS01950	COG0039	L-malate dehydrogenase activity
CULFRC58_RS01955	COG0644	oxidoreductase
CULFRC58_RS01960	COG0142	geranyltranstransferase activity
CULFRC58_RS01985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CULFRC58_RS02015	COG1902	pentaerythritol trinitrate reductase activity
CULFRC58_RS02045	COG1121	(ABC) transporter
CULFRC58_RS02050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULFRC58_RS02090	COG2197	response regulator
CULFRC58_RS02110	COG1131	(ABC) transporter
CULFRC58_RS02125	COG0701	Predicted permease
CULFRC58_RS02200	COG1302	Protein conserved in bacteria
CULFRC58_RS02260	COG0747	negative chemotaxis
CULFRC58_RS02295	COG0814	amino acid
CULFRC58_RS02300	COG1760	l-serine dehydratase
CULFRC58_RS02305	COG0252	asparaginase activity
CULFRC58_RS02315	COG0671	phosphoesterase, PA-phosphatase related
CULFRC58_RS02360	COG1175	transmembrane transport
CULFRC58_RS02365	COG3833	ABC-type maltose transport systems, permease component
CULFRC58_RS02385	COG3842	ATPase activity
CULFRC58_RS02390	COG0201	protein transport
CULFRC58_RS02395	COG0563	adenylate kinase activity
CULFRC58_RS02440	COG0203	ribosomal protein L17
CULFRC58_RS02460	COG1404	Belongs to the peptidase S8 family
CULFRC58_RS02470	COG1674	ftsk spoiiie
CULFRC58_RS02525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CULFRC58_RS02550	COG0456	acetyltransferase
CULFRC58_RS02590	COG0516	GMP reductase activity
CULFRC58_RS02635	COG2011	ABC-type metal ion transport system permease component
CULFRC58_RS02645	COG1464	Belongs to the NlpA lipoprotein family
CULFRC58_RS02650	COG1464	Belongs to the NlpA lipoprotein family
CULFRC58_RS02665	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULFRC58_RS02670	COG1121	(ABC) transporter
CULFRC58_RS02675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULFRC58_RS02680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULFRC58_RS02680	COG1321	iron dependent repressor
CULFRC58_RS02690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CULFRC58_RS02730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS02735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CULFRC58_RS02745	COG2873	o-acetylhomoserine
CULFRC58_RS02750	COG2838	Isocitrate dehydrogenase
CULFRC58_RS02755	COG2814	Major facilitator Superfamily
CULFRC58_RS02760	COG4978	Transcriptional regulator
CULFRC58_RS02760	COG0789	Transcriptional regulator
CULFRC58_RS02780	COG0180	Tryptophanyl-tRNA synthetase
CULFRC58_RS02785	COG1295	ribonuclease BN
CULFRC58_RS02825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CULFRC58_RS02830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CULFRC58_RS02830	COG1473	amidohydrolase
CULFRC58_RS02840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CULFRC58_RS02845	COG2814	Major facilitator Superfamily
CULFRC58_RS02855	COG4770	biotin carboxylase activity
CULFRC58_RS02860	COG2897	thiosulfate sulfurtransferase activity
CULFRC58_RS02865	COG0189	ligase activity
CULFRC58_RS02870	COG2755	lipolytic protein G-D-S-L family
CULFRC58_RS02870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CULFRC58_RS02880	COG0424	maF-like protein
CULFRC58_RS02885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CULFRC58_RS02890	COG1609	Transcriptional regulator
CULFRC58_RS02900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULFRC58_RS02905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULFRC58_RS02910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CULFRC58_RS02910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CULFRC58_RS02930	COG4555	ABC transporter
CULFRC58_RS02955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS02960	COG1120	ATPase activity
CULFRC58_RS02990	COG1316	TRANSCRIPTIONal
CULFRC58_RS03000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CULFRC58_RS03030	COG1482	cell wall glycoprotein biosynthetic process
CULFRC58_RS03055	COG0745	RESPONSE REGULATOR receiver
CULFRC58_RS03060	COG5002	protein histidine kinase activity
CULFRC58_RS03070	COG1040	competence protein
CULFRC58_RS03075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CULFRC58_RS03110	COG1162	GTPase activity
CULFRC58_RS03120	COG2135	peptidase activity
CULFRC58_RS03125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CULFRC58_RS03160	COG0513	Belongs to the DEAD box helicase family
CULFRC58_RS03185	COG0210	DNA helicase
CULFRC58_RS03220	COG3480	Lon protease (S16) C-terminal proteolytic domain
CULFRC58_RS03315	COG0483	inositol monophosphate 1-phosphatase activity
CULFRC58_RS03320	COG0483	inositol monophosphate 1-phosphatase activity
CULFRC58_RS03330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CULFRC58_RS03335	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CULFRC58_RS03340	COG2884	Cell division ATP-binding protein ftsE
CULFRC58_RS03345	COG2177	Part of the ABC transporter FtsEX involved in
CULFRC58_RS03355	COG0288	reversible hydration of carbon dioxide
CULFRC58_RS03425	COG1652	LysM domain
CULFRC58_RS03435	COG1278	Cold shock
CULFRC58_RS03455	COG2252	PERMEase
CULFRC58_RS03460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULFRC58_RS03480	COG0372	Belongs to the citrate synthase family
CULFRC58_RS03485	COG0545	Peptidyl-prolyl cis-trans isomerase
CULFRC58_RS03500	COG0656	L-ascorbic acid biosynthetic process
CULFRC58_RS03505	COG1024	Enoyl-CoA hydratase
CULFRC58_RS03515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CULFRC58_RS03525	COG3757	hydrolase, family 25
CULFRC58_RS03545	COG0534	Mate efflux family protein
CULFRC58_RS03550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CULFRC58_RS03555	COG0019	diaminopimelate decarboxylase activity
CULFRC58_RS03570	COG4166	transmembrane transport
CULFRC58_RS03580	COG4171	peptide transport system, permease
CULFRC58_RS03615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CULFRC58_RS03630	COG1218	3'(2'),5'-bisphosphate nucleotidase
CULFRC58_RS03635	COG1201	RNA secondary structure unwinding
CULFRC58_RS03645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CULFRC58_RS03665	COG1605	Chorismate mutase
CULFRC58_RS03695	COG1126	abc transporter atp-binding protein
CULFRC58_RS03700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CULFRC58_RS03705	COG0765	amino acid transport
CULFRC58_RS03710	COG0765	amino acid transport
CULFRC58_RS03720	COG1309	transcriptional regulator
CULFRC58_RS03750	COG0254	rRNA binding
CULFRC58_RS03760	COG0745	RESPONSE REGULATOR receiver
CULFRC58_RS03765	COG2205	protein histidine kinase activity
CULFRC58_RS03770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CULFRC58_RS03775	COG0521	Mo-molybdopterin cofactor biosynthetic process
CULFRC58_RS03775	COG0315	cyclic pyranopterin monophosphate synthase activity
CULFRC58_RS03780	COG1970	mechanosensitive ion channel activity
CULFRC58_RS03795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CULFRC58_RS03815	COG2259	Doxx family
CULFRC58_RS03825	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CULFRC58_RS03830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULFRC58_RS03835	COG3949	Membrane
CULFRC58_RS03850	COG0084	hydrolase, TatD family'
CULFRC58_RS03855	COG3583	domain protein
CULFRC58_RS03870	COG0488	(ABC) transporter
CULFRC58_RS03895	COG2326	polyphosphate kinase activity
CULFRC58_RS03940	COG0596	Alpha beta hydrolase
CULFRC58_RS03945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CULFRC58_RS03955	COG0193	aminoacyl-tRNA hydrolase activity
CULFRC58_RS03960	COG2070	2-Nitropropane dioxygenase
CULFRC58_RS03980	COG1523	belongs to the glycosyl hydrolase 13 family
CULFRC58_RS03985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CULFRC58_RS03990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CULFRC58_RS03995	COG2132	Multicopper oxidase
CULFRC58_RS04010	COG1309	transcriptional regulator
CULFRC58_RS04020	COG0531	amino acid
CULFRC58_RS04025	COG3956	TIGRFAM MazG family protein
CULFRC58_RS04090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CULFRC58_RS04160	COG0114	fumarate hydratase activity
CULFRC58_RS04165	COG1494	fructose-1,6-bisphosphatase
CULFRC58_RS04200	COG0012	GTP binding
CULFRC58_RS04210	COG2824	Alkylphosphonate utilization operon protein PhnA
CULFRC58_RS04215	COG1132	(ABC) transporter
CULFRC58_RS04220	COG1132	(ABC) transporter
CULFRC58_RS04225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CULFRC58_RS04230	COG2354	Protein conserved in bacteria
CULFRC58_RS04240	COG4721	ABC-type cobalt transport system, permease component
CULFRC58_RS04245	COG4172	Belongs to the ABC transporter superfamily
CULFRC58_RS04255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CULFRC58_RS04260	COG1051	belongs to the nudix hydrolase family
CULFRC58_RS04265	COG4166	transmembrane transport
CULFRC58_RS04270	COG0601	transmembrane transport
CULFRC58_RS04275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULFRC58_RS04290	COG1136	(ABC) transporter
CULFRC58_RS04320	COG1217	gtp-binding protein TYPA
CULFRC58_RS04360	COG1113	amino acid transport
CULFRC58_RS04370	COG1113	amino acid transport
CULFRC58_RS04380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULFRC58_RS04390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CULFRC58_RS04395	COG0463	Glycosyl transferase, family 2
CULFRC58_RS04415	COG3527	Alpha-acetolactate decarboxylase
CULFRC58_RS04420	COG0297	glycogen (starch) synthase activity
CULFRC58_RS04430	COG4122	O-methyltransferase activity
CULFRC58_RS04435	COG1595	DNA-templated transcription, initiation
CULFRC58_RS04460	COG2239	Acts as a magnesium transporter
CULFRC58_RS04470	COG0567	Dehydrogenase, E1 component
CULFRC58_RS04470	COG0508	dehydrogenase complex catalyzes the overall conversion of
CULFRC58_RS04475	COG1132	(ABC) transporter
CULFRC58_RS04485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CULFRC58_RS04490	COG2272	Belongs to the type-B carboxylesterase lipase family
CULFRC58_RS04510	COG2017	converts alpha-aldose to the beta-anomer
CULFRC58_RS04530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CULFRC58_RS04560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CULFRC58_RS04565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CULFRC58_RS04590	COG1846	Transcriptional regulator
CULFRC58_RS04605	COG1349	DNA-binding transcription factor activity
CULFRC58_RS04625	COG1556	Lactate utilization protein
CULFRC58_RS04630	COG1139	Iron-sulfur cluster binding protein
CULFRC58_RS04635	COG0247	lactate metabolic process
CULFRC58_RS04640	COG1620	l-lactate permease
CULFRC58_RS04650	COG0019	diaminopimelate decarboxylase activity
CULFRC58_RS04655	COG0460	homoserine dehydrogenase
CULFRC58_RS04705	COG0356	it plays a direct role in the translocation of protons across the membrane
CULFRC58_RS04710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CULFRC58_RS04715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CULFRC58_RS04755	COG0346	lactoylglutathione lyase activity
CULFRC58_RS04780	COG1119	ATPase activity
CULFRC58_RS04800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CULFRC58_RS04865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS04870	COG1120	ATPase activity
CULFRC58_RS04890	COG0205	6-phosphofructokinase activity
CULFRC58_RS04900	COG0667	Aldo Keto reductase
CULFRC58_RS04910	COG0583	DNA-binding transcription factor activity
CULFRC58_RS04915	COG0435	Glutathione S-transferase
CULFRC58_RS04940	COG0668	transmembrane transport
CULFRC58_RS04945	COG0028	Belongs to the TPP enzyme family
CULFRC58_RS04985	COG0473	3-isopropylmalate dehydrogenase activity
CULFRC58_RS05005	COG0179	Fumarylacetoacetate (FAA) hydrolase
CULFRC58_RS05040	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CULFRC58_RS05055	COG0601	transmembrane transport
CULFRC58_RS05060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULFRC58_RS05065	COG0444	Belongs to the ABC transporter superfamily
CULFRC58_RS05070	COG4608	Belongs to the ABC transporter superfamily
CULFRC58_RS05075	COG0747	negative chemotaxis
CULFRC58_RS05105	COG0494	nUDIX hydrolase
CULFRC58_RS05105	COG0406	alpha-ribazole phosphatase activity
CULFRC58_RS05125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CULFRC58_RS05130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CULFRC58_RS05135	COG1461	Dihydroxyacetone kinase
CULFRC58_RS05145	COG0511	ligase activity, forming carbon-carbon bonds
CULFRC58_RS05150	COG0742	ribosomal rna small subunit methyltransferase
CULFRC58_RS05175	COG0765	amino acid transport
CULFRC58_RS05205	COG0539	negative regulation of cytoplasmic translation
CULFRC58_RS05240	COG3973	AAA domain
CULFRC58_RS05250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CULFRC58_RS05265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CULFRC58_RS05280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULFRC58_RS05310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CULFRC58_RS05315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CULFRC58_RS05330	COG0165	Argininosuccinate lyase
CULFRC58_RS05335	COG2835	tetraacyldisaccharide 4'-kinase activity
CULFRC58_RS05365	COG0647	UMP catabolic process
CULFRC58_RS05395	COG0494	nUDIX hydrolase
CULFRC58_RS05400	COG4974	Belongs to the 'phage' integrase family
CULFRC58_RS05420	COG3104	oligopeptide transport
CULFRC58_RS05425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CULFRC58_RS05435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CULFRC58_RS05455	COG1160	GTP binding
CULFRC58_RS05460	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CULFRC58_RS05465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CULFRC58_RS05470	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CULFRC58_RS05475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CULFRC58_RS05480	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CULFRC58_RS05490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS05495	COG1120	ATPase activity
CULFRC58_RS05500	COG4264	IucA IucC family
CULFRC58_RS05520	COG3012	SEC-C Motif Domain Protein
CULFRC58_RS05570	COG1253	flavin adenine dinucleotide binding
CULFRC58_RS05575	COG0513	Belongs to the DEAD box helicase family
CULFRC58_RS05580	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CULFRC58_RS05590	COG0598	Magnesium transport protein CorA
CULFRC58_RS05600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CULFRC58_RS05625	COG0477	Major facilitator Superfamily
CULFRC58_RS05630	COG0277	FAD linked oxidase domain protein
CULFRC58_RS05665	COG0463	Glycosyl transferase, family 2
CULFRC58_RS05720	COG0300	oxidoreductase activity
CULFRC58_RS05735	COG0805	protein transport
CULFRC58_RS05745	COG2378	regulation of single-species biofilm formation
CULFRC58_RS05765	COG4122	O-methyltransferase activity
CULFRC58_RS05780	COG1362	aminopeptidase activity
CULFRC58_RS05800	COG1027	Aspartate ammonia-lyase
CULFRC58_RS05805	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CULFRC58_RS05820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CULFRC58_RS05825	COG1410	methionine synthase
CULFRC58_RS05825	COG0646	methionine synthase
CULFRC58_RS05845	COG0667	Aldo Keto reductase
CULFRC58_RS05855	COG0167	dihydroorotate dehydrogenase activity
CULFRC58_RS05870	COG1881	PFAM PEBP family protein
CULFRC58_RS05880	COG1461	Dihydroxyacetone kinase
CULFRC58_RS05885	COG2376	Dihydroxyacetone kinase
CULFRC58_RS05895	COG0488	(ABC) transporter
CULFRC58_RS05960	COG0791	NLP P60 protein
CULFRC58_RS05960	COG3883	PFAM NLP P60 protein
CULFRC58_RS05990	COG2848	UPF0210 protein
CULFRC58_RS06010	COG0488	(ABC) transporter
CULFRC58_RS06015	COG2151	metal-sulfur cluster biosynthetic enzyme
CULFRC58_RS06020	COG0822	iron-sulfur transferase activity
CULFRC58_RS06030	COG0396	ATPase activity
CULFRC58_RS06075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CULFRC58_RS06080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CULFRC58_RS06100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CULFRC58_RS06120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CULFRC58_RS06130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CULFRC58_RS06140	COG0322	excinuclease ABC activity
CULFRC58_RS06185	COG0242	peptide deformylase activity
CULFRC58_RS06225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CULFRC58_RS06235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CULFRC58_RS06250	COG1090	epimerase
CULFRC58_RS06275	COG0006	proline dipeptidase activity
CULFRC58_RS06280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CULFRC58_RS06285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CULFRC58_RS06295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CULFRC58_RS06315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CULFRC58_RS06370	COG1760	l-serine dehydratase
CULFRC58_RS06380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CULFRC58_RS06385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CULFRC58_RS06400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CULFRC58_RS06410	COG0747	negative chemotaxis
CULFRC58_RS06415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CULFRC58_RS06420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CULFRC58_RS06440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CULFRC58_RS06450	COG1946	Acyl-CoA thioesterase
CULFRC58_RS06465	COG0156	8-amino-7-oxononanoate synthase activity
CULFRC58_RS06475	COG0438	transferase activity, transferring glycosyl groups
CULFRC58_RS06480	COG1560	Kdo2-lipid A biosynthetic process
CULFRC58_RS06485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CULFRC58_RS06500	COG2837	iron assimilation
CULFRC58_RS06555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CULFRC58_RS06560	COG3253	May function as heme-dependent peroxidase
CULFRC58_RS06685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CULFRC58_RS06690	COG0450	alkyl hydroperoxide reductase
CULFRC58_RS06705	COG1643	Atp-dependent helicase
CULFRC58_RS06725	COG1349	DNA-binding transcription factor activity
CULFRC58_RS06730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CULFRC58_RS06735	COG1349	DNA-binding transcription factor activity
CULFRC58_RS06745	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CULFRC58_RS06745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULFRC58_RS06745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULFRC58_RS06750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CULFRC58_RS06770	COG2233	PERMEase
CULFRC58_RS06775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CULFRC58_RS06790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CULFRC58_RS06805	COG1196	nuclear chromosome segregation
CULFRC58_RS06825	COG2137	regulation of response to DNA damage stimulus
CULFRC58_RS06830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CULFRC58_RS06835	COG1268	BioY protein
CULFRC58_RS06840	COG1122	ATPase activity
CULFRC58_RS06845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CULFRC58_RS06850	COG1842	Phage shock protein A
CULFRC58_RS06855	COG1396	sequence-specific DNA binding
CULFRC58_RS06860	COG1546	Belongs to the CinA family
CULFRC58_RS06860	COG1058	Belongs to the CinA family
CULFRC58_RS06880	COG1674	ftsk spoiiie
CULFRC58_RS06890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CULFRC58_RS06930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CULFRC58_RS06940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CULFRC58_RS06945	COG0534	Mate efflux family protein
CULFRC58_RS06990	COG3022	response to hydroperoxide
CULFRC58_RS06995	COG1648	precorrin-2 dehydrogenase activity
CULFRC58_RS06995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CULFRC58_RS07000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CULFRC58_RS07005	COG0523	cobalamin synthesis protein
CULFRC58_RS07010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CULFRC58_RS07010	COG2169	Transcriptional regulator
CULFRC58_RS07065	COG0768	penicillin binding
CULFRC58_RS07075	COG0750	zinc metalloprotease
CULFRC58_RS07130	COG4974	Belongs to the 'phage' integrase family
CULFRC58_RS07145	COG0792	nuclease activity
CULFRC58_RS07160	COG0352	thiamine-phosphate diphosphorylase activity
CULFRC58_RS07165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CULFRC58_RS07165	COG2022	thiamine diphosphate biosynthetic process
CULFRC58_RS07175	COG2022	thiamine diphosphate biosynthetic process
CULFRC58_RS07180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CULFRC58_RS07185	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CULFRC58_RS07185	COG0352	thiamine-phosphate diphosphorylase activity
CULFRC58_RS07185	COG0351	phosphomethylpyrimidine kinase
CULFRC58_RS07200	COG0681	Belongs to the peptidase S26 family
CULFRC58_RS07215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULFRC58_RS07215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CULFRC58_RS07215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULFRC58_RS07225	COG0336	Belongs to the RNA methyltransferase TrmD family
CULFRC58_RS07230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CULFRC58_RS07250	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CULFRC58_RS07275	COG1254	Belongs to the acylphosphatase family
CULFRC58_RS07280	COG1115	amino acid carrier protein
CULFRC58_RS07310	COG0686	Belongs to the AlaDH PNT family
CULFRC58_RS07315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CULFRC58_RS07320	COG1929	Belongs to the glycerate kinase type-1 family
CULFRC58_RS07340	COG0058	SHG alpha-glucan phosphorylase activity
CULFRC58_RS07350	COG0469	pyruvate kinase activity
CULFRC58_RS07360	COG0134	indole-3-glycerol-phosphate synthase activity
CULFRC58_RS07380	COG0483	inositol monophosphate 1-phosphatase activity
CULFRC58_RS07445	COG2176	DNA-directed DNA polymerase activity
CULFRC58_RS07470	COG1739	Uncharacterized protein family UPF0029
CULFRC58_RS07475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CULFRC58_RS07500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CULFRC58_RS07515	COG0252	asparaginase activity
CULFRC58_RS07535	COG3599	regulation of cell shape
CULFRC58_RS07545	COG1799	cell septum assembly
CULFRC58_RS07550	COG1496	oxidoreductase activity
CULFRC58_RS07555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CULFRC58_RS07560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CULFRC58_RS07565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CULFRC58_RS07595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CULFRC58_RS07600	COG0768	penicillin binding
CULFRC58_RS07640	COG0142	geranyltranstransferase activity
CULFRC58_RS07655	COG0515	serine threonine protein kinase
CULFRC58_RS07655	COG2815	serine threonine protein kinase
CULFRC58_RS07660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CULFRC58_RS07680	COG1940	carbohydrate kinase activity
CULFRC58_RS07685	COG0438	transferase activity, transferring glycosyl groups
CULFRC58_RS07695	COG0791	NLP P60 protein
CULFRC58_RS07750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CULFRC58_RS07760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CULFRC58_RS07775	COG0508	dehydrogenase complex catalyzes the overall conversion of
CULFRC58_RS07785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CULFRC58_RS07785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CULFRC58_RS07790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CULFRC58_RS07795	COG0509	glycine decarboxylation via glycine cleavage system
CULFRC58_RS07815	COG1120	ATPase activity
CULFRC58_RS07820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS07825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS07850	COG0174	glutamine synthetase
CULFRC58_RS07865	COG3547	Transposase (IS116 IS110 IS902 family)
CULFRC58_RS07880	COG3237	CsbD-like
CULFRC58_RS07890	COG2056	Na+-H+ antiporter family
CULFRC58_RS07900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CULFRC58_RS07930	COG0174	glutamine synthetase
CULFRC58_RS07950	COG0557	exoribonuclease II activity
CULFRC58_RS07990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CULFRC58_RS08005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CULFRC58_RS08010	COG0596	Alpha beta hydrolase
CULFRC58_RS08035	COG2860	membrane
CULFRC58_RS08230	COG0629	single-stranded DNA binding
CULFRC58_RS08270	COG0756	dUTP diphosphatase activity
CULFRC58_RS08395	COG0423	glycine-tRNA ligase activity
CULFRC58_RS08420	COG1381	Involved in DNA repair and RecF pathway recombination
CULFRC58_RS08475	COG1022	Amp-dependent synthetase and ligase
CULFRC58_RS08525	COG1132	(ABC) transporter
CULFRC58_RS08530	COG1114	Component of the transport system for branched-chain amino acids
CULFRC58_RS08535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CULFRC58_RS08545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULFRC58_RS08560	COG0747	negative chemotaxis
CULFRC58_RS08565	COG0601	transmembrane transport
CULFRC58_RS08570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULFRC58_RS08575	COG4172	Belongs to the ABC transporter superfamily
CULFRC58_RS08585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CULFRC58_RS08590	COG2391	methyltransferase activity
CULFRC58_RS08615	COG4172	Belongs to the ABC transporter superfamily
CULFRC58_RS08620	COG1116	anion transmembrane transporter activity
CULFRC58_RS08645	COG1280	lysine exporter protein (LysE YggA)
CULFRC58_RS08670	COG1307	EDD domain protein, DegV family
CULFRC58_RS08675	COG0406	alpha-ribazole phosphatase activity
CULFRC58_RS08685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CULFRC58_RS08700	COG2832	Protein of unknown function (DUF454)
CULFRC58_RS08705	COG2985	domain, Protein
CULFRC58_RS08705	COG0569	domain protein
CULFRC58_RS08730	COG1530	ribonuclease E activity
CULFRC58_RS08745	COG2423	ornithine cyclodeaminase activity
CULFRC58_RS08755	COG0285	dihydrofolate synthase activity
CULFRC58_RS08795	COG0544	peptidyl-prolyl cis-trans isomerase activity
CULFRC58_RS08830	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CULFRC58_RS08845	COG0668	transmembrane transport
CULFRC58_RS08920	COG1131	(ABC) transporter
CULFRC58_RS08925	COG3336	cytochrome c oxidase
CULFRC58_RS08930	COG1966	Carbon starvation protein
CULFRC58_RS08950	COG0604	alcohol dehydrogenase
CULFRC58_RS08975	COG1376	ErfK ybiS ycfS ynhG family protein
CULFRC58_RS08985	COG2130	NADP-dependent
CULFRC58_RS08990	COG1335	isochorismatase
CULFRC58_RS09035	COG2197	response regulator
CULFRC58_RS09045	COG0726	polysaccharide deacetylase
CULFRC58_RS09085	COG1234	tRNA 3'-trailer cleavage
CULFRC58_RS09110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CULFRC58_RS09145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULFRC58_RS09155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULFRC58_RS09175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CULFRC58_RS09210	COG0640	Transcriptional regulator
CULFRC58_RS09215	COG2217	Heavy metal translocating P-type atpase
CULFRC58_RS09235	COG0033	Phosphoglucomutase
CULFRC58_RS09250	COG0577	efflux transmembrane transporter activity
CULFRC58_RS09250	COG1136	(ABC) transporter
CULFRC58_RS09255	COG1136	(ABC) transporter
CULFRC58_RS09255	COG0577	efflux transmembrane transporter activity
CULFRC58_RS09285	COG2197	response regulator
CULFRC58_RS09295	COG1045	serine acetyltransferase
CULFRC58_RS09315	COG0371	Dehydrogenase
CULFRC58_RS09335	COG1271	oxidase subunit
CULFRC58_RS09340	COG1294	oxidase, subunit
CULFRC58_RS09345	COG4988	ABC transporter
CULFRC58_RS09350	COG1132	(ABC) transporter
CULFRC58_RS09375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CULFRC58_RS09405	COG1597	lipid kinase activity
CULFRC58_RS09420	COG0354	folic acid binding
CULFRC58_RS09445	COG1780	Probably involved in ribonucleotide reductase function
CULFRC58_RS09450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULFRC58_RS09460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CULFRC58_RS09465	COG0047	phosphoribosylformylglycinamidine synthase activity
CULFRC58_RS09470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CULFRC58_RS09475	COG0386	Belongs to the glutathione peroxidase family
CULFRC58_RS09495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CULFRC58_RS09500	COG0569	domain protein
CULFRC58_RS09505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CULFRC58_RS09510	COG0151	Belongs to the GarS family
CULFRC58_RS09515	COG0537	adenosine 5'-monophosphoramidase activity
CULFRC58_RS09525	COG2205	protein histidine kinase activity
CULFRC58_RS09530	COG0745	RESPONSE REGULATOR receiver
CULFRC58_RS09560	COG0028	Belongs to the TPP enzyme family
CULFRC58_RS09620	COG1609	Transcriptional regulator
CULFRC58_RS09625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULFRC58_RS09645	COG1329	Transcriptional regulator
CULFRC58_RS09650	COG2847	Copper chaperone PCu(A)C
CULFRC58_RS09660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CULFRC58_RS09670	COG0288	reversible hydration of carbon dioxide
CULFRC58_RS09685	COG0542	response to heat
CULFRC58_RS09695	COG0477	Major facilitator Superfamily
CULFRC58_RS09700	COG1957	nucleoside hydrolase
CULFRC58_RS09735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CULFRC58_RS09750	COG1301	dicarboxylic acid transport
CULFRC58_RS09755	COG1012	belongs to the aldehyde dehydrogenase family
CULFRC58_RS09760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULFRC58_RS09765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CULFRC58_RS09770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CULFRC58_RS09805	COG0302	gtp cyclohydrolase
CULFRC58_RS09810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CULFRC58_RS09815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CULFRC58_RS09825	COG2027	D-alanyl-D-alanine carboxypeptidase
CULFRC58_RS09830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CULFRC58_RS09835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CULFRC58_RS09840	COG1301	dicarboxylic acid transport
CULFRC58_RS09860	COG2326	polyphosphate kinase activity
CULFRC58_RS09905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CULFRC58_RS09905	COG2111	Na H antiporter
CULFRC58_RS09910	COG1006	Multisubunit Na H antiporter MnhC subunit
CULFRC58_RS09915	COG0651	ATP synthesis coupled electron transport
CULFRC58_RS09935	COG1051	belongs to the nudix hydrolase family
CULFRC58_RS09955	COG0242	peptide deformylase activity
CULFRC58_RS09965	COG0708	Exodeoxyribonuclease III
CULFRC58_RS09970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CULFRC58_RS09980	COG1131	(ABC) transporter
CULFRC58_RS09995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CULFRC58_RS10010	COG0280	phosphate acetyltransferase
CULFRC58_RS10030	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CULFRC58_RS10035	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CULFRC58_RS10075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CULFRC58_RS10090	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CULFRC58_RS10095	COG3005	denitrification pathway
CULFRC58_RS10110	COG4129	membrane
CULFRC58_RS10120	COG4129	membrane
CULFRC58_RS10155	COG0191	fructose-bisphosphate aldolase activity
CULFRC58_RS10170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CULFRC58_RS10185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CULFRC58_RS10225	COG1131	(ABC) transporter
CULFRC58_RS10280	COG1136	(ABC) transporter
CULFRC58_RS10280	COG0577	efflux transmembrane transporter activity
CULFRC58_RS10285	COG1136	(ABC) transporter
CULFRC58_RS10290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CULFRC58_RS10295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CULFRC58_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
CULFRC58_RS10330	COG0789	Transcriptional regulator
CULFRC58_RS10345	COG0443	Heat shock 70 kDa protein
CULFRC58_RS10375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULFRC58_RS10380	COG0601	transmembrane transport
CULFRC58_RS10400	COG0247	lactate metabolic process
CULFRC58_RS10400	COG2181	nitrate reductase activity
CULFRC58_RS10415	COG1120	ATPase activity
CULFRC58_RS10420	COG4139	cobalamin transport
CULFRC58_RS10430	COG0829	nickel cation binding
CULFRC58_RS10435	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CULFRC58_RS10440	COG0830	nickel cation binding
CULFRC58_RS10445	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CULFRC58_RS10450	COG0804	urea catabolic process
CULFRC58_RS10455	COG0832	Belongs to the urease beta subunit family
CULFRC58_RS10460	COG0831	urea catabolic process
CULFRC58_RS10480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CULFRC58_RS10480	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CULFRC58_RS10500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CULFRC58_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
CULFRC58_RS10525	COG1132	(ABC) transporter
CULFRC58_RS10535	COG1129	ABC transporter
CULFRC58_RS10555	COG1472	Belongs to the glycosyl hydrolase 3 family
CULFRC58_RS10565	COG4981	capsule polysaccharide biosynthetic process
CULFRC58_RS10570	COG2755	lipolytic protein G-D-S-L family
CULFRC58_RS10570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CULFRC58_RS10590	COG0500	methyltransferase
CULFRC58_RS10635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULFRC58_RS10640	COG3321	synthase
CULFRC58_RS10640	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CULFRC58_RS10640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CULFRC58_RS10645	COG0318	PFAM AMP-dependent synthetase and ligase
CULFRC58_RS10650	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CULFRC58_RS10660	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CULFRC58_RS10660	COG5479	isomerase activity
CULFRC58_RS10665	COG5650	phosphatidylinositol metabolic process
CULFRC58_RS10675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CULFRC58_RS10680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CULFRC58_RS10685	COG0671	phosphoesterase, PA-phosphatase related
CULFRC58_RS10690	COG1216	Glycosyl transferase, family 2
CULFRC58_RS10700	COG0671	phosphoesterase, PA-phosphatase related
CULFRC58_RS10710	COG0584	glycerophosphoryl diester phosphodiesterase
CULFRC58_RS10715	COG2271	Major facilitator Superfamily
CULFRC58_RS10725	COG1120	ATPase activity
CULFRC58_RS10730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULFRC58_RS10735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CULFRC58_RS10745	COG0561	phosphatase activity
CULFRC58_RS10760	COG2188	Transcriptional regulator
CULFRC58_RS10780	COG0077	Prephenate dehydratase
CULFRC58_RS10795	COG1316	TRANSCRIPTIONal
CULFRC58_RS10810	COG1115	amino acid carrier protein
CULFRC58_RS10825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CULFRC58_RS10855	COG0431	NADPH-dependent FMN reductase
CULFRC58_RS10860	COG0583	DNA-binding transcription factor activity
CULFRC58_RS10865	COG2814	Major facilitator Superfamily
CULFRC58_RS10880	COG5650	phosphatidylinositol metabolic process
CULFRC58_RS10900	COG2197	response regulator
CULFRC58_RS10920	COG3764	Sortase (surface protein transpeptidase)
CULFRC58_RS10925	COG0706	membrane insertase activity
CULFRC58_RS10950	COG0564	pseudouridine synthase activity
CULFRC58_RS10975	COG1131	(ABC) transporter
CULFRC58_RS10990	COG1842	Phage shock protein A
CULFRC58_RS10995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CULFRC58_RS11020	COG0596	Alpha beta hydrolase
CULFRC58_RS11035	COG0477	Major facilitator Superfamily
CULFRC58_RS11040	COG0305	Participates in initiation and elongation during chromosome replication
CULFRC58_RS11045	COG3387	PFAM Glycoside hydrolase 15-related
CULFRC58_RS11055	COG0629	single-stranded DNA binding
CULFRC58_RS11075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CULFRC58_RS11095	COG4221	oxidoreductase activity
CULFRC58_RS11110	COG0586	Pfam SNARE associated Golgi protein
CULFRC58_RS11120	COG0783	Belongs to the Dps family
CULFRC58_RS11125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CULFRC58_RS11130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CULFRC58_RS11130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CULFRC58_RS11175	COG3851	Histidine kinase
CULFRC58_RS11180	COG2197	response regulator
CULFRC58_RS11210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CULFRC58_RS11220	COG1940	carbohydrate kinase activity
CULFRC58_RS11225	COG2186	Transcriptional regulator
CULFRC58_RS11230	COG0747	negative chemotaxis
CULFRC58_RS11235	COG0601	transmembrane transport
CULFRC58_RS11240	COG0444	Belongs to the ABC transporter superfamily
CULFRC58_RS11245	COG4608	Belongs to the ABC transporter superfamily
CULFRC58_RS11250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CULFRC58_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
CULFRC58_RS11320	COG3422	double-strand break repair
CULFRC58_RS11335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CULFRC58_RS11355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CULFRC58_RS11360	COG0512	Glutamine amidotransferase of anthranilate synthase
CULFRC58_RS11370	COG0134	indole-3-glycerol-phosphate synthase activity
CULFRC58_RS11370	COG0135	phosphoribosylanthranilate isomerase activity
CULFRC58_RS11375	COG0133	tryptophan synthase activity
CULFRC58_RS11405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CULFRC58_RS11410	COG1678	Uncharacterized ACR, COG1678
CULFRC58_RS11415	COG0617	tRNA 3'-terminal CCA addition
CULFRC58_RS11450	COG3409	Peptidoglycan-binding domain 1 protein
CULFRC58_RS11450	COG0860	N-Acetylmuramoyl-L-alanine amidase
CULFRC58_RS11465	COG1192	Involved in chromosome partitioning
CULFRC58_RS11485	COG0230	Belongs to the bacterial ribosomal protein bL34 family