locus-tag	class	description
AFK63_RS00005	COG1640	4-alpha-glucanotransferase
AFK63_RS00010	COG1278	Cold shock
AFK63_RS00020	COG1040	competence protein
AFK63_RS00045	COG1918	ferrous iron import across plasma membrane
AFK63_RS00055	COG2183	response to ionizing radiation
AFK63_RS00060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFK63_RS00080	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AFK63_RS00090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AFK63_RS00095	COG1011	Hydrolase
AFK63_RS00105	COG0494	nUDIX hydrolase
AFK63_RS00110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AFK63_RS00115	COG4972	Pilus assembly protein
AFK63_RS00135	COG4796	Type ii and iii secretion system protein
AFK63_RS00150	COG3266	domain, Protein
AFK63_RS00155	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AFK63_RS00160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFK63_RS00170	COG0180	Tryptophanyl-tRNA synthetase
AFK63_RS00175	COG2188	Transcriptional regulator
AFK63_RS00185	COG1082	Xylose isomerase domain protein TIM barrel
AFK63_RS00190	COG2222	sugar isomerase
AFK63_RS00195	COG0531	amino acid
AFK63_RS00210	COG2146	nitrite reductase [NAD(P)H] activity
AFK63_RS00215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFK63_RS00235	COG0512	Glutamine amidotransferase of anthranilate synthase
AFK63_RS00245	COG1289	transmembrane transporter activity
AFK63_RS00255	COG1765	OsmC-like protein
AFK63_RS00260	COG3954	Phosphoribulokinase
AFK63_RS00270	COG0429	hydrolase of the alpha beta-hydrolase fold
AFK63_RS00280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFK63_RS00300	COG0488	(ABC) transporter
AFK63_RS00315	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AFK63_RS00320	COG1047	Peptidyl-prolyl cis-trans
AFK63_RS00330	COG0545	Peptidyl-prolyl cis-trans isomerase
AFK63_RS00335	COG2964	Protein conserved in bacteria
AFK63_RS00390	COG0051	transcription antitermination factor activity, RNA binding
AFK63_RS00415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFK63_RS00430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFK63_RS00495	COG0201	protein transport
AFK63_RS00505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFK63_RS00530	COG0789	Transcriptional regulator
AFK63_RS00535	COG3036	rescue of stalled ribosome
AFK63_RS00565	COG0758	DNA mediated transformation
AFK63_RS00570	COG2922	Belongs to the Smg family
AFK63_RS00595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFK63_RS00630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFK63_RS00635	COG2224	Isocitrate lyase
AFK63_RS00670	COG4650	regulator
AFK63_RS00680	COG1690	Belongs to the RtcB family
AFK63_RS00685	COG3541	Predicted nucleotidyltransferase
AFK63_RS00690	COG0527	aspartate kinase activity
AFK63_RS00720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFK63_RS00725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFK63_RS00750	COG3842	ATPase activity
AFK63_RS00780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AFK63_RS00790	COG0534	Mate efflux family protein
AFK63_RS00795	COG3237	CsbD-like
AFK63_RS00800	COG0735	belongs to the Fur family
AFK63_RS00840	COG1448	Aminotransferase
AFK63_RS00845	COG2831	hemolysin activation secretion protein
AFK63_RS00855	COG2315	Protein conserved in bacteria
AFK63_RS00860	COG3210	domain, Protein
AFK63_RS00865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFK63_RS00890	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AFK63_RS00900	COG0789	Transcriptional regulator
AFK63_RS00910	COG2252	PERMEase
AFK63_RS00915	COG0025	NhaP-type Na H and K H
AFK63_RS00920	COG0673	inositol 2-dehydrogenase activity
AFK63_RS00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFK63_RS00930	COG3162	membrane
AFK63_RS00940	COG1301	dicarboxylic acid transport
AFK63_RS00955	COG0326	Molecular chaperone. Has ATPase activity
AFK63_RS00970	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AFK63_RS00975	COG2824	Alkylphosphonate utilization operon protein PhnA
AFK63_RS00980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFK63_RS01000	COG0625	glutathione transferase activity
AFK63_RS01005	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AFK63_RS01020	COG1309	transcriptional regulator
AFK63_RS01035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AFK63_RS01040	COG1027	Aspartate ammonia-lyase
AFK63_RS01045	COG3030	protein affecting phage T7 exclusion by the F plasmid
AFK63_RS01065	COG1509	lysine 2,3-aminomutase activity
AFK63_RS01075	COG5510	response to toxic substance
AFK63_RS01090	COG3040	lipid binding
AFK63_RS01105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFK63_RS01110	COG1053	succinate dehydrogenase
AFK63_RS01120	COG3264	Mechanosensitive ion channel
AFK63_RS01120	COG1511	domain protein
AFK63_RS01155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFK63_RS01160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFK63_RS01160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFK63_RS01165	COG0802	atpase or kinase
AFK63_RS01190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFK63_RS01195	COG0330	HflC and HflK could
AFK63_RS01200	COG0330	HflC and HflK could
AFK63_RS01205	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AFK63_RS01225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFK63_RS01230	COG3766	membrane
AFK63_RS01235	COG5463	Belongs to the UPF0441 family
AFK63_RS01240	COG0754	glutathionylspermidine amidase activity
AFK63_RS01245	COG1960	acyl-CoA dehydrogenase activity
AFK63_RS01260	COG3650	response to hydrogen peroxide
AFK63_RS01265	COG1073	alpha beta
AFK63_RS01280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFK63_RS01290	COG3061	Opacity-associated protein A
AFK63_RS01295	COG0545	Peptidyl-prolyl cis-trans isomerase
AFK63_RS01300	COG1113	amino acid transport
AFK63_RS01310	COG0840	transmembrane signaling receptor activity
AFK63_RS01315	COG0697	spore germination
AFK63_RS01325	COG2169	Transcriptional regulator
AFK63_RS01325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFK63_RS01335	COG0702	epimerase
AFK63_RS01340	COG1733	regulation of RNA biosynthetic process
AFK63_RS01355	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AFK63_RS01365	COG1253	flavin adenine dinucleotide binding
AFK63_RS01380	COG0729	surface antigen
AFK63_RS01385	COG2911	Protein conserved in bacteria
AFK63_RS01390	COG2105	PFAM AIG2 family protein
AFK63_RS01405	COG3188	usher protein
AFK63_RS01410	COG3121	Chaperone
AFK63_RS01420	COG3539	Fimbrial protein
AFK63_RS01445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AFK63_RS01450	COG1879	ABC-type sugar transport system periplasmic component
AFK63_RS01455	COG1129	ABC transporter
AFK63_RS01460	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFK63_RS01465	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFK63_RS01480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFK63_RS01495	COG0312	modulator of DNA gyrase
AFK63_RS01530	COG3964	amidohydrolase
AFK63_RS01545	COG3711	transcriptional antiterminator
AFK63_RS01545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK63_RS01550	COG0602	queuosine metabolic process
AFK63_RS01560	COG0583	DNA-binding transcription factor activity
AFK63_RS01565	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFK63_RS01570	COG0366	Alpha amylase catalytic
AFK63_RS01575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS01575	COG1263	PTS System
AFK63_RS01590	COG1309	transcriptional regulator
AFK63_RS01595	COG2999	glutathione oxidoreductase activity
AFK63_RS01615	COG1979	alcohol dehydrogenase
AFK63_RS01625	COG2207	Transcriptional regulator
AFK63_RS01630	COG0586	Pfam SNARE associated Golgi protein
AFK63_RS01645	COG0848	biopolymer transport protein
AFK63_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS01655	COG1349	DNA-binding transcription factor activity
AFK63_RS01680	COG0667	Aldo Keto reductase
AFK63_RS01685	COG0668	transmembrane transport
AFK63_RS01690	COG4580	involved in the transport of maltose and maltodextrins
AFK63_RS01695	COG1447	Phosphotransferase system cellobiose-specific component IIA
AFK63_RS01700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AFK63_RS01710	COG1609	Transcriptional regulator
AFK63_RS01715	COG3647	Membrane
AFK63_RS01720	COG4625	pathogenesis
AFK63_RS01735	COG1811	Na channel or pump
AFK63_RS01740	COG1982	Orn Lys Arg decarboxylase major
AFK63_RS01755	COG3493	citrate carrier protein
AFK63_RS01760	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFK63_RS01790	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AFK63_RS01805	COG1194	a g-specific adenine glycosylase
AFK63_RS01815	COG3171	Protein conserved in bacteria
AFK63_RS01840	COG0523	cobalamin synthesis protein
AFK63_RS01845	COG2879	small protein
AFK63_RS01850	COG1966	Carbon starvation protein
AFK63_RS01855	COG0840	transmembrane signaling receptor activity
AFK63_RS01895	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AFK63_RS01920	COG0358	DNA primase activity
AFK63_RS01925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFK63_RS01940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFK63_RS01955	COG4991	sh3 domain protein
AFK63_RS01960	COG3025	triphosphatase activity
AFK63_RS01975	COG2960	long-chain fatty acid transporting porin activity
AFK63_RS01990	COG3384	dioxygenase
AFK63_RS01995	COG0754	glutathionylspermidine amidase activity
AFK63_RS02005	COG1538	Outer membrane efflux protein
AFK63_RS02010	COG0494	nUDIX hydrolase
AFK63_RS02015	COG3151	Protein conserved in bacteria
AFK63_RS02020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFK63_RS02025	COG3150	esterase
AFK63_RS02070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFK63_RS02085	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AFK63_RS02090	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFK63_RS02100	COG0204	Acyl-transferase
AFK63_RS02110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFK63_RS02125	COG0762	integral membrane protein
AFK63_RS02130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFK63_RS02135	COG2805	Type II/IV secretion system protein
AFK63_RS02165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFK63_RS02170	COG2356	endonuclease I
AFK63_RS02185	COG2814	Major facilitator Superfamily
AFK63_RS02195	COG1166	arginine decarboxylase activity
AFK63_RS02205	COG0501	Belongs to the peptidase M48B family
AFK63_RS02210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFK63_RS02230	COG0191	fructose-bisphosphate aldolase activity
AFK63_RS02235	COG0668	transmembrane transport
AFK63_RS02240	COG1279	arginine transmembrane transporter activity
AFK63_RS02245	COG2968	Membrane
AFK63_RS02255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AFK63_RS02260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFK63_RS02265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFK63_RS02275	COG3079	Belongs to the UPF0149 family
AFK63_RS02280	COG0006	proline dipeptidase activity
AFK63_RS02285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFK63_RS02290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFK63_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS02315	COG2723	6-phospho-beta-galactosidase activity
AFK63_RS02320	COG1737	Transcriptional regulator
AFK63_RS02330	COG1272	protein, Hemolysin III
AFK63_RS02340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AFK63_RS02350	COG0716	FMN binding
AFK63_RS02355	COG4974	Belongs to the 'phage' integrase family
AFK63_RS02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFK63_RS02380	COG4942	peptidase
AFK63_RS02405	COG0183	Belongs to the thiolase family
AFK63_RS02415	COG0823	Involved in the tonB-independent uptake of proteins
AFK63_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS02430	COG0823	Involved in the tonB-independent uptake of proteins
AFK63_RS02440	COG3842	ATPase activity
AFK63_RS02445	COG0395	ABC-type sugar transport system, permease component
AFK63_RS02450	COG1175	transmembrane transport
AFK63_RS02455	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AFK63_RS02460	COG1917	Cupin 2, conserved barrel domain protein
AFK63_RS02465	COG1794	racemase activity, acting on amino acids and derivatives
AFK63_RS02470	COG0583	DNA-binding transcription factor activity
AFK63_RS02480	COG1609	Transcriptional regulator
AFK63_RS02485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AFK63_RS02490	COG2723	6-phospho-beta-galactosidase activity
AFK63_RS02495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AFK63_RS02500	COG2186	Transcriptional regulator
AFK63_RS02510	COG1609	Transcriptional regulator
AFK63_RS02525	COG0667	Aldo Keto reductase
AFK63_RS02535	COG0861	Integral membrane protein TerC family
AFK63_RS02565	COG2165	general secretion pathway protein
AFK63_RS02570	COG4795	General secretion pathway protein
AFK63_RS02575	COG4967	type IV pilus modification protein PilV
AFK63_RS02580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AFK63_RS02590	COG1074	ATP-dependent DNA helicase activity
AFK63_RS02595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFK63_RS02600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFK63_RS02600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFK63_RS02605	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFK63_RS02620	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AFK63_RS02625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFK63_RS02630	COG2166	iron-sulfur cluster assembly
AFK63_RS02635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFK63_RS02645	COG0583	DNA-binding transcription factor activity
AFK63_RS02650	COG2363	Small membrane protein
AFK63_RS02665	COG1760	l-serine dehydratase
AFK63_RS02670	COG0814	amino acid
AFK63_RS02675	COG1611	Belongs to the LOG family
AFK63_RS02690	COG3098	single-species biofilm formation
AFK63_RS02695	COG0564	pseudouridine synthase activity
AFK63_RS02700	COG0716	FMN binding
AFK63_RS02705	COG4999	Histidine kinase
AFK63_RS02705	COG3850	Histidine kinase
AFK63_RS02705	COG2205	protein histidine kinase activity
AFK63_RS02705	COG3437	response regulator, receiver
AFK63_RS02715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFK63_RS02720	COG3956	TIGRFAM MazG family protein
AFK63_RS02735	COG1737	Transcriptional regulator
AFK63_RS02745	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AFK63_RS02750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AFK63_RS02755	COG0602	queuosine metabolic process
AFK63_RS02760	COG0720	synthase
AFK63_RS02780	COG2234	aminopeptidase activity
AFK63_RS02870	COG0163	prenyltransferase activity
AFK63_RS02875	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFK63_RS02920	COG0765	amino acid transport
AFK63_RS02925	COG1126	abc transporter atp-binding protein
AFK63_RS02930	COG2951	lytic endotransglycosylase activity
AFK63_RS02935	COG1546	Belongs to the CinA family
AFK63_RS02955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFK63_RS02985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFK63_RS02990	COG1238	metal cluster binding
AFK63_RS03010	COG2814	Major facilitator Superfamily
AFK63_RS03015	COG1566	PFAM secretion protein HlyD family protein
AFK63_RS03020	COG1846	Transcriptional regulator
AFK63_RS03025	COG2814	Major facilitator Superfamily
AFK63_RS03035	COG4176	ABC-type proline glycine betaine transport system permease component
AFK63_RS03040	COG4175	Glycine betaine
AFK63_RS03050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFK63_RS03065	COG4575	ribosome binding
AFK63_RS03095	COG0840	transmembrane signaling receptor activity
AFK63_RS03120	COG1132	(ABC) transporter
AFK63_RS03125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFK63_RS03135	COG2867	negative regulation of translational initiation
AFK63_RS03150	COG0497	DNA recombination
AFK63_RS03165	COG4536	flavin adenine dinucleotide binding
AFK63_RS03170	COG4137	Cytochrome C assembly protein
AFK63_RS03175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFK63_RS03210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AFK63_RS03215	COG0287	Prephenate dehydrogenase
AFK63_RS03215	COG1605	Chorismate mutase
AFK63_RS03225	COG1605	Chorismate mutase
AFK63_RS03225	COG0077	Prephenate dehydratase
AFK63_RS03230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AFK63_RS03240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFK63_RS03255	COG0542	response to heat
AFK63_RS03280	COG0028	Belongs to the TPP enzyme family
AFK63_RS03290	COG0477	Major facilitator Superfamily
AFK63_RS03295	COG5544	Lipoprotein
AFK63_RS03300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFK63_RS03310	COG3148	PFAM DTW domain containing protein
AFK63_RS03315	COG3118	belongs to the thioredoxin family
AFK63_RS03320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFK63_RS03335	COG0513	Belongs to the DEAD box helicase family
AFK63_RS03345	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFK63_RS03365	COG3086	response to oxidative stress
AFK63_RS03375	COG0681	Belongs to the peptidase S26 family
AFK63_RS03395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AFK63_RS03405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFK63_RS03410	COG1737	Transcriptional regulator
AFK63_RS03420	COG1263	PTS System
AFK63_RS03420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS03425	COG0560	Phosphoserine phosphatase
AFK63_RS03435	COG0047	phosphoribosylformylglycinamidine synthase activity
AFK63_RS03435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFK63_RS03440	COG2205	protein histidine kinase activity
AFK63_RS03445	COG3170	Tfp pilus assembly protein FimV
AFK63_RS03450	COG2204	response regulator
AFK63_RS03455	COG0347	Belongs to the P(II) protein family
AFK63_RS03475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFK63_RS03480	COG2814	Major facilitator Superfamily
AFK63_RS03485	COG3711	transcriptional antiterminator
AFK63_RS03490	COG3683	transport system, periplasmic component
AFK63_RS03495	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AFK63_RS03520	COG0822	iron-sulfur transferase activity
AFK63_RS03540	COG0633	Ferredoxin
AFK63_RS03545	COG2975	iron-sulfur cluster assembly
AFK63_RS03570	COG1737	Transcriptional regulator
AFK63_RS03575	COG2897	thiosulfate sulfurtransferase activity
AFK63_RS03585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS03585	COG2190	(PTS) system
AFK63_RS03585	COG1263	PTS System
AFK63_RS03590	COG2373	Large extracellular alpha-helical protein
AFK63_RS03595	COG4953	penicillin-binding protein 1C
AFK63_RS03625	COG2976	Protein conserved in bacteria
AFK63_RS03640	COG1645	bacterial-type flagellum-dependent swarming motility
AFK63_RS03660	COG0517	IMP dehydrogenase activity
AFK63_RS03660	COG0516	GMP reductase activity
AFK63_RS03670	COG0582	viral genome integration into host DNA
AFK63_RS03690	COG3093	addiction module antidote protein HigA
AFK63_RS03705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFK63_RS03715	COG2200	EAL domain
AFK63_RS03730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AFK63_RS03745	COG2233	PERMEase
AFK63_RS03755	COG1393	Belongs to the ArsC family
AFK63_RS03760	COG4783	chaperone-mediated protein folding
AFK63_RS03765	COG0628	permease
AFK63_RS03770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFK63_RS03775	COG2716	regulation of RNA biosynthetic process
AFK63_RS03785	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AFK63_RS03795	COG2321	neutral zinc metallopeptidase
AFK63_RS03805	COG0400	carboxylic ester hydrolase activity
AFK63_RS03820	COG1393	Belongs to the ArsC family
AFK63_RS03830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFK63_RS03835	COG2197	response regulator
AFK63_RS03845	COG5342	invasion associated locus B
AFK63_RS03860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFK63_RS03875	COG1120	ATPase activity
AFK63_RS03880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK63_RS03885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK63_RS03895	COG4592	Periplasmic binding protein
AFK63_RS03900	COG1169	isochorismate synthase
AFK63_RS03905	COG1021	2,3-dihydroxybenzoate-AMP ligase
AFK63_RS03910	COG1535	isochorismatase
AFK63_RS03910	COG3433	isochorismatase activity
AFK63_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS03925	COG1966	Carbon starvation protein
AFK63_RS03930	COG2879	small protein
AFK63_RS03950	COG0371	Dehydrogenase
AFK63_RS03955	COG1129	ABC transporter
AFK63_RS03960	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFK63_RS03990	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFK63_RS04000	COG3111	PFAM Bacterial OB fold (BOF) protein
AFK63_RS04015	COG2837	iron assimilation
AFK63_RS04020	COG4150	thiosulfate binding
AFK63_RS04025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AFK63_RS04030	COG4208	sulfate ABC transporter
AFK63_RS04035	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFK63_RS04060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK63_RS04085	COG3530	Putative quorum-sensing-regulated virulence factor
AFK63_RS04125	COG3415	Transposase
AFK63_RS04140	COG2199	diguanylate cyclase activity
AFK63_RS04140	COG2200	EAL domain
AFK63_RS04145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AFK63_RS04160	COG0667	Aldo Keto reductase
AFK63_RS04165	COG3961	Belongs to the TPP enzyme family
AFK63_RS04175	COG3279	Response regulator of the LytR AlgR family
AFK63_RS04180	COG3275	phosphorelay sensor kinase activity
AFK63_RS04190	COG0436	Aminotransferase
AFK63_RS04250	COG0583	DNA-binding transcription factor activity
AFK63_RS04255	COG2271	Major facilitator Superfamily
AFK63_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS04265	COG3959	Transketolase, thiamine diphosphate binding domain
AFK63_RS04270	COG3958	Transketolase
AFK63_RS04295	COG2116	formate transmembrane transporter activity
AFK63_RS04300	COG4133	protoheme IX ABC transporter activity
AFK63_RS04305	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFK63_RS04310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFK63_RS04315	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFK63_RS04325	COG1138	Cytochrome C-type biogenesis protein
AFK63_RS04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFK63_RS04335	COG3088	subunit of a heme lyase
AFK63_RS04335	COG4235	cytochrome complex assembly
AFK63_RS04340	COG4235	cytochrome complex assembly
AFK63_RS04340	COG3088	subunit of a heme lyase
AFK63_RS04350	COG2067	long-chain fatty acid transport protein
AFK63_RS04355	COG3691	Protein conserved in bacteria
AFK63_RS04370	COG2062	phosphohistidine phosphatase, SixA
AFK63_RS04395	COG0730	response to heat
AFK63_RS04400	COG3101	peptidyl-lysine hydroxylation
AFK63_RS04415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFK63_RS04435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFK63_RS04445	COG0586	Pfam SNARE associated Golgi protein
AFK63_RS04455	COG0285	dihydrofolate synthase activity
AFK63_RS04460	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AFK63_RS04465	COG1286	toxin biosynthetic process
AFK63_RS04470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFK63_RS04475	COG0163	prenyltransferase activity
AFK63_RS04485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFK63_RS04495	COG4160	amino acid transport
AFK63_RS04500	COG4598	ABC transporter
AFK63_RS04515	COG1090	epimerase
AFK63_RS04520	COG0625	glutathione transferase activity
AFK63_RS04525	COG0625	glutathione transferase activity
AFK63_RS04530	COG0622	Phosphoesterase
AFK63_RS04540	COG1309	transcriptional regulator
AFK63_RS04575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFK63_RS04580	COG0490	domain, Protein
AFK63_RS04580	COG0471	metal ion transport
AFK63_RS04590	COG0436	Aminotransferase
AFK63_RS04595	COG0583	DNA-binding transcription factor activity
AFK63_RS04620	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFK63_RS04640	COG0839	Belongs to the complex I subunit 6 family
AFK63_RS04650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFK63_RS04655	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK63_RS04670	COG2153	protein acetylation
AFK63_RS04675	COG4575	ribosome binding
AFK63_RS04680	COG1169	isochorismate synthase
AFK63_RS04710	COG3647	Membrane
AFK63_RS04750	COG2271	Major facilitator Superfamily
AFK63_RS04755	COG0584	glycerophosphoryl diester phosphodiesterase
AFK63_RS04760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFK63_RS04770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFK63_RS04790	COG2197	response regulator
AFK63_RS04795	COG2198	Histidine kinase
AFK63_RS04795	COG0642	Histidine kinase
AFK63_RS04810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFK63_RS04810	COG2169	Transcriptional regulator
AFK63_RS04815	COG3145	DNA-N1-methyladenine dioxygenase activity
AFK63_RS04820	COG4615	Cyclic peptide transporter
AFK63_RS04825	COG0659	secondary active sulfate transmembrane transporter activity
AFK63_RS04850	COG3615	Tellurite resistance protein tehB
AFK63_RS04855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFK63_RS04870	COG2207	Transcriptional regulator
AFK63_RS04895	COG3083	sulfuric ester hydrolase activity
AFK63_RS04915	COG1061	Type III restriction enzyme res subunit
AFK63_RS04925	COG2814	Major facilitator Superfamily
AFK63_RS04935	COG4172	Belongs to the ABC transporter superfamily
AFK63_RS04940	COG4239	(ABC) transporter, permease
AFK63_RS04945	COG4174	ABC transporter (Permease)
AFK63_RS04950	COG4166	transmembrane transport
AFK63_RS04955	COG2200	EAL domain
AFK63_RS04960	COG0791	NLP P60 protein
AFK63_RS04965	COG0671	phosphoesterase, PA-phosphatase related
AFK63_RS04970	COG0523	cobalamin synthesis protein
AFK63_RS04975	COG0246	Mannitol dehydrogenase
AFK63_RS05010	COG1105	Belongs to the carbohydrate kinase PfkB family
AFK63_RS05015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFK63_RS05015	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AFK63_RS05015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFK63_RS05020	COG1082	Xylose isomerase domain protein TIM barrel
AFK63_RS05020	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AFK63_RS05030	COG2855	membrane
AFK63_RS05035	COG0583	DNA-binding transcription factor activity
AFK63_RS05040	COG0833	amino acid
AFK63_RS05050	COG0477	Major facilitator Superfamily
AFK63_RS05055	COG0302	gtp cyclohydrolase
AFK63_RS05060	COG2311	Membrane
AFK63_RS05070	COG1879	ABC-type sugar transport system periplasmic component
AFK63_RS05075	COG1129	ABC transporter
AFK63_RS05085	COG2949	membrane
AFK63_RS05095	COG1346	cytolysis
AFK63_RS05105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFK63_RS05120	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS05125	COG0586	Pfam SNARE associated Golgi protein
AFK63_RS05135	COG1686	Belongs to the peptidase S11 family
AFK63_RS05145	COG0277	FAD linked oxidase domain protein
AFK63_RS05150	COG1472	Belongs to the glycosyl hydrolase 3 family
AFK63_RS05155	COG1732	Glycine betaine
AFK63_RS05160	COG1174	glycine betaine transport
AFK63_RS05165	COG1125	glycine betaine transport
AFK63_RS05170	COG1174	glycine betaine transport
AFK63_RS05175	COG0789	Transcriptional regulator
AFK63_RS05185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AFK63_RS05195	COG0489	protein tyrosine kinase activity
AFK63_RS05205	COG3275	phosphorelay sensor kinase activity
AFK63_RS05215	COG0840	transmembrane signaling receptor activity
AFK63_RS05225	COG0488	(ABC) transporter
AFK63_RS05230	COG5455	response to cobalt ion
AFK63_RS05245	COG0351	phosphomethylpyrimidine kinase
AFK63_RS05250	COG1830	Aldolase
AFK63_RS05260	COG0826	peptidase U32
AFK63_RS05265	COG0745	RESPONSE REGULATOR receiver
AFK63_RS05270	COG2205	protein histidine kinase activity
AFK63_RS05295	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AFK63_RS05305	COG0443	Heat shock 70 kDa protein
AFK63_RS05310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AFK63_RS05315	COG5001	Diguanylate cyclase
AFK63_RS05315	COG5002	protein histidine kinase activity
AFK63_RS05315	COG3447	MASE1 domain protein
AFK63_RS05330	COG2982	Protein involved in outer membrane biogenesis
AFK63_RS05335	COG1253	flavin adenine dinucleotide binding
AFK63_RS05350	COG3206	protein involved in exopolysaccharide biosynthesis
AFK63_RS05350	COG0489	protein tyrosine kinase activity
AFK63_RS05355	COG0463	Glycosyl transferase, family 2
AFK63_RS05360	COG1045	serine acetyltransferase
AFK63_RS05365	COG0438	transferase activity, transferring glycosyl groups
AFK63_RS05375	COG1216	Glycosyl transferase, family 2
AFK63_RS05380	COG0110	maltose O-acetyltransferase activity
AFK63_RS05385	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AFK63_RS05390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFK63_RS05395	COG1051	belongs to the nudix hydrolase family
AFK63_RS05400	COG0297	glycogen (starch) synthase activity
AFK63_RS05405	COG0662	Cupin 2, conserved barrel domain protein
AFK63_RS05405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AFK63_RS05415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFK63_RS05420	COG2244	polysaccharide biosynthetic process
AFK63_RS05425	COG2327	Polysaccharide pyruvyl transferase
AFK63_RS05430	COG0438	transferase activity, transferring glycosyl groups
AFK63_RS05450	COG1091	dTDP-4-dehydrorhamnose reductase activity
AFK63_RS05480	COG2244	polysaccharide biosynthetic process
AFK63_RS05500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AFK63_RS05540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFK63_RS05545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFK63_RS05550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFK63_RS05555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFK63_RS05560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFK63_RS05565	COG0531	amino acid
AFK63_RS05570	COG2925	Exonuclease
AFK63_RS05590	COG1289	transmembrane transporter activity
AFK63_RS05605	COG0582	viral genome integration into host DNA
AFK63_RS05615	COG0534	Mate efflux family protein
AFK63_RS05635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFK63_RS05640	COG2200	EAL domain
AFK63_RS05645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFK63_RS05665	COG0477	Major facilitator Superfamily
AFK63_RS05690	COG3706	GGDEF domain
AFK63_RS05690	COG5001	Diguanylate cyclase
AFK63_RS05690	COG4251	negative regulation of phosphorylation
AFK63_RS05690	COG2203	Gaf domain
AFK63_RS05695	COG0583	DNA-binding transcription factor activity
AFK63_RS05705	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS05715	COG0737	Belongs to the 5'-nucleotidase family
AFK63_RS05730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AFK63_RS05735	COG1418	mRNA catabolic process
AFK63_RS05740	COG0270	DNA (cytosine-5-)-methyltransferase activity
AFK63_RS05745	COG3727	T/G mismatch-specific endonuclease activity
AFK63_RS05750	COG0697	spore germination
AFK63_RS05755	COG2354	Protein conserved in bacteria
AFK63_RS05760	COG5475	Uncharacterized small protein (DUF2158)
AFK63_RS05785	COG2197	response regulator
AFK63_RS05800	COG1338	Plays a role in the flagellum-specific transport system
AFK63_RS05820	COG1580	Controls the rotational direction of flagella during chemotaxis
AFK63_RS05835	COG1157	protein secretion by the type III secretion system
AFK63_RS05840	COG1317	bacterial-type flagellum organization
AFK63_RS05860	COG2135	peptidase activity
AFK63_RS05875	COG0425	Belongs to the sulfur carrier protein TusA family
AFK63_RS05880	COG2391	methyltransferase activity
AFK63_RS05900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFK63_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS05945	COG3959	Transketolase, thiamine diphosphate binding domain
AFK63_RS05950	COG3958	Transketolase
AFK63_RS05955	COG0318	PFAM AMP-dependent synthetase and ligase
AFK63_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFK63_RS05990	COG0765	amino acid transport
AFK63_RS05995	COG1126	abc transporter atp-binding protein
AFK63_RS06000	COG2197	response regulator
AFK63_RS06010	COG2197	response regulator
AFK63_RS06040	COG0454	-acetyltransferase
AFK63_RS06045	COG0814	amino acid
AFK63_RS06050	COG1528	Iron-storage protein
AFK63_RS06070	COG0477	Major facilitator Superfamily
AFK63_RS06090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AFK63_RS06095	COG1528	Iron-storage protein
AFK63_RS06105	COG4297	protein containing double-stranded beta helix domain
AFK63_RS06110	COG1879	ABC-type sugar transport system periplasmic component
AFK63_RS06120	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFK63_RS06165	COG0835	chemotaxis
AFK63_RS06215	COG0745	RESPONSE REGULATOR receiver
AFK63_RS06230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFK63_RS06255	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AFK63_RS06270	COG3102	Protein conserved in bacteria
AFK63_RS06285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFK63_RS06290	COG3142	Participates in the control of copper homeostasis
AFK63_RS06300	COG0443	Heat shock 70 kDa protein
AFK63_RS06305	COG2214	Heat shock protein DnaJ domain protein
AFK63_RS06310	COG1652	LysM domain
AFK63_RS06325	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AFK63_RS06330	COG1801	Protein of unknown function DUF72
AFK63_RS06335	COG1335	isochorismatase
AFK63_RS06345	COG0494	nUDIX hydrolase
AFK63_RS06370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFK63_RS06380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AFK63_RS06385	COG0739	heme binding
AFK63_RS06390	COG1560	Kdo2-lipid A biosynthetic process
AFK63_RS06400	COG4804	nuclease activity
AFK63_RS06405	COG2003	Belongs to the UPF0758 family
AFK63_RS06430	COG5489	Protein of unknown function (DUF736)
AFK63_RS06475	COG4959	Type IV secretory pathway protease TraF
AFK63_RS06500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK63_RS06570	COG0667	Aldo Keto reductase
AFK63_RS06585	COG0583	DNA-binding transcription factor activity
AFK63_RS06605	COG4962	Type ii secretion system protein e
AFK63_RS06610	COG3838	Conjugal transfer protein Trbc
AFK63_RS06620	COG3451	type IV secretory pathway VirB4
AFK63_RS06635	COG3846	protein secretion by the type IV secretion system
AFK63_RS06660	COG0469	pyruvate kinase activity
AFK63_RS06665	COG1737	Transcriptional regulator
AFK63_RS06670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFK63_RS06675	COG0129	dihydroxy-acid dehydratase activity
AFK63_RS06680	COG0800	Aldolase
AFK63_RS06690	COG3141	response to X-ray
AFK63_RS06705	COG2979	Protein of unknown function (DUF533)
AFK63_RS06710	COG1770	oligopeptidase
AFK63_RS06715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFK63_RS06725	COG2372	response to copper ion
AFK63_RS06730	COG1276	copper resistance
AFK63_RS06760	COG3008	intermembrane lipid transfer
AFK63_RS06765	COG2995	paraquat-inducible protein a
AFK63_RS06770	COG1956	GAF domain-containing protein
AFK63_RS06790	COG1414	Transcriptional regulator
AFK63_RS06820	COG2226	methyltransferase
AFK63_RS06835	COG3716	PTS system mannose fructose sorbose family IID component
AFK63_RS06840	COG3715	PTS system
AFK63_RS06845	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK63_RS06845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS06850	COG1253	flavin adenine dinucleotide binding
AFK63_RS06855	COG2200	EAL domain
AFK63_RS06860	COG1760	l-serine dehydratase
AFK63_RS06880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFK63_RS06885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFK63_RS06920	COG0251	oxidation-reduction process
AFK63_RS06925	COG1199	ATP-dependent helicase activity
AFK63_RS06935	COG3065	identical protein binding
AFK63_RS06955	COG2894	cell division
AFK63_RS06970	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFK63_RS07000	COG2719	SpoVR family
AFK63_RS07010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFK63_RS07020	COG0583	DNA-binding transcription factor activity
AFK63_RS07025	COG0667	Aldo Keto reductase
AFK63_RS07035	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFK63_RS07040	COG2807	transmembrane transport
AFK63_RS07045	COG2207	Transcriptional regulator
AFK63_RS07065	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFK63_RS07085	COG4774	siderophore transport
AFK63_RS07095	COG1609	Transcriptional regulator
AFK63_RS07105	COG3842	ATPase activity
AFK63_RS07125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFK63_RS07130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFK63_RS07145	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFK63_RS07160	COG3012	SEC-C Motif Domain Protein
AFK63_RS07160	COG3318	Belongs to the UPF0149 family
AFK63_RS07165	COG0012	GTP binding
AFK63_RS07185	COG0659	secondary active sulfate transmembrane transporter activity
AFK63_RS07215	COG2890	protein-(glutamine-N5) methyltransferase activity
AFK63_RS07235	COG0387	Pfam Sodium calcium exchanger
AFK63_RS07240	COG4572	Cation transport regulator
AFK63_RS07245	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AFK63_RS07255	COG0840	transmembrane signaling receptor activity
AFK63_RS07260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AFK63_RS07265	COG3707	response regulator
AFK63_RS07270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFK63_RS07275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFK63_RS07280	COG1116	anion transmembrane transporter activity
AFK63_RS07285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFK63_RS07285	COG2146	nitrite reductase [NAD(P)H] activity
AFK63_RS07290	COG0243	molybdopterin cofactor binding
AFK63_RS07300	COG4932	domain protein
AFK63_RS07305	COG2197	response regulator
AFK63_RS07310	COG3850	Histidine kinase
AFK63_RS07315	COG2223	nitrite transmembrane transporter activity
AFK63_RS07320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AFK63_RS07325	COG1140	nitrate reductase beta subunit
AFK63_RS07330	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AFK63_RS07335	COG2181	nitrate reductase activity
AFK63_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS07360	COG0477	Major facilitator Superfamily
AFK63_RS07375	COG0788	formyltetrahydrofolate deformylase activity
AFK63_RS07385	COG0745	RESPONSE REGULATOR receiver
AFK63_RS07390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFK63_RS07410	COG1435	thymidine kinase activity
AFK63_RS07415	COG1012	belongs to the aldehyde dehydrogenase family
AFK63_RS07415	COG1454	alcohol dehydrogenase
AFK63_RS07420	COG2095	MarC family integral membrane protein
AFK63_RS07430	COG0601	transmembrane transport
AFK63_RS07435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFK63_RS07440	COG0444	Belongs to the ABC transporter superfamily
AFK63_RS07445	COG4608	Belongs to the ABC transporter superfamily
AFK63_RS07450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFK63_RS07470	COG2350	Protein conserved in bacteria
AFK63_RS07500	COG0727	PFAM Uncharacterised protein family (UPF0153)
AFK63_RS07505	COG3047	cAMP biosynthetic process
AFK63_RS07530	COG0512	Glutamine amidotransferase of anthranilate synthase
AFK63_RS07530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFK63_RS07535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFK63_RS07540	COG0613	PHP domain protein
AFK63_RS07545	COG0009	L-threonylcarbamoyladenylate synthase
AFK63_RS07555	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AFK63_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS07565	COG0616	signal peptide processing
AFK63_RS07595	COG0671	phosphoesterase, PA-phosphatase related
AFK63_RS07600	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AFK63_RS07605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AFK63_RS07615	COG0023	Translation Initiation Factor
AFK63_RS07625	COG1349	DNA-binding transcription factor activity
AFK63_RS07630	COG1882	Formate acetyltransferase
AFK63_RS07635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AFK63_RS07650	COG1024	Enoyl-CoA hydratase
AFK63_RS07655	COG5001	Diguanylate cyclase
AFK63_RS07665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFK63_RS07665	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFK63_RS07675	COG4172	Belongs to the ABC transporter superfamily
AFK63_RS07685	COG4171	peptide transport system, permease
AFK63_RS07700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AFK63_RS07705	COG1842	Phage shock protein A
AFK63_RS07715	COG1983	PspC domain protein
AFK63_RS07725	COG0366	Alpha amylase catalytic
AFK63_RS07730	COG1653	transport
AFK63_RS07735	COG1175	transmembrane transport
AFK63_RS07740	COG0395	ABC-type sugar transport system, permease component
AFK63_RS07745	COG1063	alcohol dehydrogenase
AFK63_RS07750	COG1082	Xylose isomerase domain protein TIM barrel
AFK63_RS07770	COG1396	sequence-specific DNA binding
AFK63_RS07785	COG1846	Transcriptional regulator
AFK63_RS07830	COG3772	lysozyme
AFK63_RS07850	COG1802	Transcriptional regulator
AFK63_RS07850	COG4626	Terminase
AFK63_RS07890	COG4386	tail sheath protein
AFK63_RS07930	COG3299	homolog of phage Mu protein gp47
AFK63_RS07935	COG3778	Protein conserved in bacteria
AFK63_RS07960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFK63_RS07965	COG1393	Belongs to the ArsC family
AFK63_RS07970	COG0431	NADPH-dependent FMN reductase
AFK63_RS07995	COG0673	inositol 2-dehydrogenase activity
AFK63_RS08000	COG1554	hydrolase, family 65, central catalytic
AFK63_RS08005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFK63_RS08015	COG0456	acetyltransferase
AFK63_RS08020	COG1609	Transcriptional regulator
AFK63_RS08025	COG3106	COG3106 Predicted ATPase
AFK63_RS08045	COG4948	Mandelate Racemase Muconate Lactonizing
AFK63_RS08050	COG2866	Carboxypeptidase
AFK63_RS08055	COG4166	transmembrane transport
AFK63_RS08070	COG4774	siderophore transport
AFK63_RS08075	COG2382	esterase
AFK63_RS08090	COG3729	General stress protein
AFK63_RS08095	COG5001	Diguanylate cyclase
AFK63_RS08095	COG3300	MHYT domain
AFK63_RS08130	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS08140	COG3284	Transcriptional regulator
AFK63_RS08160	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFK63_RS08160	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFK63_RS08160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK63_RS08160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFK63_RS08165	COG3042	response to heat
AFK63_RS08170	COG3187	Heat shock protein
AFK63_RS08175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFK63_RS08180	COG2911	Protein conserved in bacteria
AFK63_RS08190	COG3784	Protein of unknown function (DUF1318)
AFK63_RS08205	COG1643	Atp-dependent helicase
AFK63_RS08210	COG4122	O-methyltransferase activity
AFK63_RS08245	COG0477	Major facilitator Superfamily
AFK63_RS08250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AFK63_RS08255	COG1012	belongs to the aldehyde dehydrogenase family
AFK63_RS08260	COG2755	lipolytic protein G-D-S-L family
AFK63_RS08260	COG0657	acetylesterase activity
AFK63_RS08265	COG3038	cytochrome b561
AFK63_RS08270	COG0477	Major facilitator Superfamily
AFK63_RS08300	COG0840	transmembrane signaling receptor activity
AFK63_RS08305	COG3685	Protein conserved in bacteria
AFK63_RS08310	COG1902	pentaerythritol trinitrate reductase activity
AFK63_RS08315	COG0583	DNA-binding transcription factor activity
AFK63_RS08320	COG5383	Protein conserved in bacteria
AFK63_RS08335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFK63_RS08340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFK63_RS08345	COG0500	methyltransferase
AFK63_RS08355	COG3135	benzoate transporter
AFK63_RS08360	COG1396	sequence-specific DNA binding
AFK63_RS08365	COG0826	peptidase U32
AFK63_RS08370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFK63_RS08400	COG3591	Belongs to the peptidase S1B family
AFK63_RS08405	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AFK63_RS08410	COG2814	Major facilitator Superfamily
AFK63_RS08415	COG0583	DNA-binding transcription factor activity
AFK63_RS08420	COG1940	carbohydrate kinase activity
AFK63_RS08450	COG3136	membrane protein required for alginate biosynthesis
AFK63_RS08455	COG3381	protein complex oligomerization
AFK63_RS08460	COG3302	dmso reductase anchor subunit
AFK63_RS08465	COG0437	4 iron, 4 sulfur cluster binding
AFK63_RS08470	COG0243	molybdopterin cofactor binding
AFK63_RS08485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFK63_RS08500	COG4948	Mandelate Racemase Muconate Lactonizing
AFK63_RS08505	COG2271	Major facilitator Superfamily
AFK63_RS08510	COG0246	Mannitol dehydrogenase
AFK63_RS08525	COG1802	Transcriptional regulator
AFK63_RS08530	COG4221	oxidoreductase activity
AFK63_RS08535	COG0339	signal peptide processing
AFK63_RS08545	COG3781	membrane
AFK63_RS08550	COG3729	General stress protein
AFK63_RS08560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFK63_RS08605	COG2814	Major facilitator Superfamily
AFK63_RS08620	COG4977	sequence-specific DNA binding
AFK63_RS08625	COG1846	Transcriptional regulator
AFK63_RS08630	COG2814	Major facilitator Superfamily
AFK63_RS08640	COG0039	L-malate dehydrogenase activity
AFK63_RS08650	COG0583	DNA-binding transcription factor activity
AFK63_RS08655	COG1012	belongs to the aldehyde dehydrogenase family
AFK63_RS08660	COG0840	transmembrane signaling receptor activity
AFK63_RS08675	COG2199	diguanylate cyclase activity
AFK63_RS08685	COG3447	MASE1 domain protein
AFK63_RS08685	COG5002	protein histidine kinase activity
AFK63_RS08685	COG5001	Diguanylate cyclase
AFK63_RS08710	COG3250	beta-galactosidase activity
AFK63_RS08715	COG2205	protein histidine kinase activity
AFK63_RS08715	COG5002	protein histidine kinase activity
AFK63_RS08715	COG0784	Response regulator, receiver
AFK63_RS08780	COG0456	acetyltransferase
AFK63_RS08780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFK63_RS08790	COG0596	Alpha beta hydrolase
AFK63_RS08795	COG0789	Transcriptional regulator
AFK63_RS08800	COG0791	NLP P60 protein
AFK63_RS08835	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AFK63_RS08860	COG3209	COG3209 Rhs family protein
AFK63_RS08880	COG2207	Transcriptional regulator
AFK63_RS08885	COG4221	oxidoreductase activity
AFK63_RS08905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFK63_RS08915	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS08920	COG1064	alcohol dehydrogenase
AFK63_RS08935	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AFK63_RS08940	COG3685	Protein conserved in bacteria
AFK63_RS08945	COG3546	catalase activity
AFK63_RS08955	COG0778	Nitroreductase
AFK63_RS08980	COG2175	clavaminate synthase activity
AFK63_RS08985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AFK63_RS08990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFK63_RS09000	COG4772	TonB-dependent receptor
AFK63_RS09005	COG0366	Alpha amylase catalytic
AFK63_RS09010	COG4221	oxidoreductase activity
AFK63_RS09015	COG0840	transmembrane signaling receptor activity
AFK63_RS09025	COG1802	Transcriptional regulator
AFK63_RS09040	COG0601	transmembrane transport
AFK63_RS09060	COG2130	NADP-dependent
AFK63_RS09070	COG1247	-acetyltransferase
AFK63_RS09075	COG3238	Protein conserved in bacteria
AFK63_RS09080	COG2084	Dehydrogenase
AFK63_RS09090	COG0747	negative chemotaxis
AFK63_RS09110	COG4677	pectinesterase activity
AFK63_RS09125	COG0840	transmembrane signaling receptor activity
AFK63_RS09140	COG3302	dmso reductase anchor subunit
AFK63_RS09145	COG0437	4 iron, 4 sulfur cluster binding
AFK63_RS09150	COG0243	molybdopterin cofactor binding
AFK63_RS09160	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AFK63_RS09190	COG1012	belongs to the aldehyde dehydrogenase family
AFK63_RS09195	COG1177	transmembrane transport
AFK63_RS09200	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFK63_RS09205	COG3842	ATPase activity
AFK63_RS09210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AFK63_RS09215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFK63_RS09220	COG1271	oxidase subunit
AFK63_RS09225	COG1294	oxidase, subunit
AFK63_RS09235	COG2076	Multidrug Resistance protein
AFK63_RS09240	COG2211	Major facilitator Superfamily
AFK63_RS09255	COG0747	negative chemotaxis
AFK63_RS09260	COG0601	transmembrane transport
AFK63_RS09265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFK63_RS09270	COG4172	Belongs to the ABC transporter superfamily
AFK63_RS09275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFK63_RS09285	COG0561	phosphatase activity
AFK63_RS09290	COG2840	Smr protein MutS2
AFK63_RS09295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFK63_RS09300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFK63_RS09305	COG0589	response to stress
AFK63_RS09310	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AFK63_RS09315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AFK63_RS09325	COG0531	amino acid
AFK63_RS09335	COG0745	RESPONSE REGULATOR receiver
AFK63_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS09350	COG2205	protein histidine kinase activity
AFK63_RS09360	COG0114	fumarate hydratase activity
AFK63_RS09370	COG1482	cell wall glycoprotein biosynthetic process
AFK63_RS09375	COG5339	Protein conserved in bacteria
AFK63_RS09380	COG1609	Transcriptional regulator
AFK63_RS09385	COG1263	PTS System
AFK63_RS09385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS09390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFK63_RS09395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFK63_RS09400	COG0385	Bile acid
AFK63_RS09405	COG0673	inositol 2-dehydrogenase activity
AFK63_RS09450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFK63_RS09460	COG0625	glutathione transferase activity
AFK63_RS09465	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AFK63_RS09505	COG1566	PFAM secretion protein HlyD family protein
AFK63_RS09510	COG1289	transmembrane transporter activity
AFK63_RS09520	COG4989	oxidoreductase activity
AFK63_RS09525	COG3313	Fe-S protein
AFK63_RS09535	COG1309	transcriptional regulator
AFK63_RS09540	COG1902	pentaerythritol trinitrate reductase activity
AFK63_RS09545	COG0346	lactoylglutathione lyase activity
AFK63_RS09555	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AFK63_RS09560	COG0791	NLP P60 protein
AFK63_RS09565	COG2814	Major facilitator Superfamily
AFK63_RS09575	COG0583	DNA-binding transcription factor activity
AFK63_RS09580	COG2814	Major facilitator Superfamily
AFK63_RS09585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFK63_RS09590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AFK63_RS09595	COG2723	6-phospho-beta-galactosidase activity
AFK63_RS09600	COG1609	Transcriptional regulator
AFK63_RS09605	COG0307	riboflavin synthase, alpha
AFK63_RS09635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFK63_RS09660	COG1733	regulation of RNA biosynthetic process
AFK63_RS09670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFK63_RS09690	COG0583	DNA-binding transcription factor activity
AFK63_RS09695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFK63_RS09715	COG2814	Major facilitator Superfamily
AFK63_RS09720	COG0583	DNA-binding transcription factor activity
AFK63_RS09725	COG3383	formate dehydrogenase (NAD+) activity
AFK63_RS09730	COG3383	formate dehydrogenase (NAD+) activity
AFK63_RS09735	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AFK63_RS09740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AFK63_RS09745	COG3383	formate dehydrogenase (NAD+) activity
AFK63_RS09750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFK63_RS09760	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AFK63_RS09770	COG3260	NADH ubiquinone oxidoreductase 20
AFK63_RS09775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFK63_RS09780	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AFK63_RS09780	COG3261	NADH dehydrogenase
AFK63_RS09785	COG0650	Formate hydrogenlyase subunit 4
AFK63_RS09790	COG0651	ATP synthesis coupled electron transport
AFK63_RS09795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFK63_RS09805	COG0375	protein maturation
AFK63_RS09810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AFK63_RS09815	COG0298	carbon dioxide binding
AFK63_RS09820	COG0409	Hydrogenase expression formation protein
AFK63_RS09825	COG0309	Hydrogenase expression formation protein (HypE)
AFK63_RS09835	COG0531	amino acid
AFK63_RS09840	COG0174	glutamine synthetase
AFK63_RS09845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFK63_RS09850	COG1396	sequence-specific DNA binding
AFK63_RS09850	COG1917	Cupin 2, conserved barrel domain protein
AFK63_RS09855	COG1012	belongs to the aldehyde dehydrogenase family
AFK63_RS09860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFK63_RS09865	COG3468	outer membrane autotransporter barrel domain protein
AFK63_RS09865	COG3468	outer membrane autotransporter barrel domain protein
AFK63_RS09885	COG1376	ErfK ybiS ycfS ynhG family protein
AFK63_RS09900	COG0719	Fe-S assembly protein
AFK63_RS09905	COG0396	ATPase activity
AFK63_RS09910	COG0719	Fe-S assembly protein
AFK63_RS09915	COG0316	Belongs to the HesB IscA family
AFK63_RS09920	COG2050	protein possibly involved in aromatic compounds catabolism
AFK63_RS09925	COG0247	lactate metabolic process
AFK63_RS09925	COG0277	FAD linked oxidase domain protein
AFK63_RS09930	COG0628	permease
AFK63_RS09935	COG1472	Belongs to the glycosyl hydrolase 3 family
AFK63_RS09940	COG2211	Major facilitator Superfamily
AFK63_RS09945	COG0574	Belongs to the PEP-utilizing enzyme family
AFK63_RS09945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFK63_RS09970	COG1486	melibiose metabolic process
AFK63_RS09975	COG0791	NLP P60 protein
AFK63_RS09985	COG0386	Belongs to the glutathione peroxidase family
AFK63_RS09990	COG4139	cobalamin transport
AFK63_RS10030	COG0456	acetyltransferase
AFK63_RS10035	COG0583	DNA-binding transcription factor activity
AFK63_RS10055	COG3546	catalase activity
AFK63_RS10070	COG3137	Salt-induced outer membrane protein
AFK63_RS10075	COG1105	Belongs to the carbohydrate kinase PfkB family
AFK63_RS10085	COG3001	Fructosamine kinase
AFK63_RS10095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFK63_RS10100	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS10105	COG1988	membrane-bound metal-dependent
AFK63_RS10110	COG1823	symporter activity
AFK63_RS10120	COG0753	catalase activity
AFK63_RS10125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFK63_RS10140	COG0322	excinuclease ABC activity
AFK63_RS10150	COG3678	ATP-independent chaperone mediated protein folding
AFK63_RS10180	COG0708	Exodeoxyribonuclease III
AFK63_RS10185	COG0494	nUDIX hydrolase
AFK63_RS10195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFK63_RS10205	COG0778	Nitroreductase
AFK63_RS10210	COG0616	signal peptide processing
AFK63_RS10215	COG0252	asparaginase activity
AFK63_RS10220	COG1335	isochorismatase
AFK63_RS10225	COG3139	Protein of unknown function (DUF1315)
AFK63_RS10235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFK63_RS10245	COG3713	MltA-interacting MipA family protein
AFK63_RS10250	COG2766	serine protein kinase
AFK63_RS10260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AFK63_RS10265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFK63_RS10275	COG2807	transmembrane transport
AFK63_RS10280	COG0504	CTP synthase activity
AFK63_RS10285	COG3189	MarR family transcriptional regulator
AFK63_RS10295	COG2990	Protein conserved in bacteria
AFK63_RS10300	COG0835	chemotaxis
AFK63_RS10300	COG0784	Response regulator, receiver
AFK63_RS10310	COG1278	Cold shock
AFK63_RS10315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFK63_RS10350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFK63_RS10360	COG1253	flavin adenine dinucleotide binding
AFK63_RS10365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFK63_RS10380	COG2132	Multicopper oxidase
AFK63_RS10395	COG1276	copper resistance
AFK63_RS10400	COG0745	RESPONSE REGULATOR receiver
AFK63_RS10405	COG2205	protein histidine kinase activity
AFK63_RS10580	COG3179	chitinase
AFK63_RS10600	COG0484	heat shock protein binding
AFK63_RS10610	COG3646	Phage regulatory protein
AFK63_RS10610	COG3645	SOS response
AFK63_RS10615	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
AFK63_RS10630	COG4725	Belongs to the MT-A70-like family
AFK63_RS10640	COG1802	Transcriptional regulator
AFK63_RS10640	COG4626	Terminase
AFK63_RS10685	COG0582	viral genome integration into host DNA
AFK63_RS10690	COG0538	isocitrate dehydrogenase activity
AFK63_RS10695	COG1187	pseudouridine synthase activity
AFK63_RS10705	COG0840	transmembrane signaling receptor activity
AFK63_RS10720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFK63_RS10735	COG2850	peptidyl-arginine hydroxylation
AFK63_RS10760	COG1177	transmembrane transport
AFK63_RS10780	COG4591	ABC-type transport system involved in lipoprotein release permease component
AFK63_RS10790	COG4591	ABC-type transport system involved in lipoprotein release permease component
AFK63_RS10795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFK63_RS10800	COG1388	LysM domain
AFK63_RS10800	COG1376	ErfK ybiS ycfS ynhG family protein
AFK63_RS10810	COG1309	transcriptional regulator
AFK63_RS10815	COG3134	Outer membrane lipoprotein
AFK63_RS10820	COG1252	NADH dehydrogenase
AFK63_RS10835	COG0510	thiamine kinase activity
AFK63_RS10845	COG5633	Lipoprotein
AFK63_RS10850	COG0537	adenosine 5'-monophosphoramidase activity
AFK63_RS10855	COG4773	Receptor
AFK63_RS10860	COG1263	PTS System
AFK63_RS10860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS10865	COG0084	hydrolase, TatD family'
AFK63_RS10870	COG0470	DNA polymerase III
AFK63_RS10880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFK63_RS10885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFK63_RS10890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFK63_RS10900	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS10930	COG0424	maF-like protein
AFK63_RS10945	COG1530	ribonuclease E activity
AFK63_RS10950	COG0583	DNA-binding transcription factor activity
AFK63_RS10955	COG2814	Major facilitator Superfamily
AFK63_RS10965	COG1256	bacterial-type flagellum assembly
AFK63_RS10985	COG4786	Flagellar basal body rod
AFK63_RS11005	COG1558	bacterial-type flagellum-dependent cell motility
AFK63_RS11010	COG1815	bacterial-type flagellum-dependent cell motility
AFK63_RS11035	COG0673	inositol 2-dehydrogenase activity
AFK63_RS11045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFK63_RS11055	COG2999	glutathione oxidoreductase activity
AFK63_RS11085	COG3038	cytochrome b561
AFK63_RS11100	COG1560	Kdo2-lipid A biosynthetic process
AFK63_RS11110	COG5645	(Lipo)protein
AFK63_RS11130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFK63_RS11150	COG3381	protein complex oligomerization
AFK63_RS11170	COG3188	usher protein
AFK63_RS11175	COG3121	Chaperone
AFK63_RS11190	COG0243	molybdopterin cofactor binding
AFK63_RS11205	COG1702	phosphate starvation-inducible protein PhoH
AFK63_RS11215	COG2822	iron ion transport
AFK63_RS11225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AFK63_RS11235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFK63_RS11240	COG0506	proline dehydrogenase activity
AFK63_RS11240	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AFK63_RS11240	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AFK63_RS11245	COG1309	transcriptional regulator
AFK63_RS11280	COG2233	PERMEase
AFK63_RS11315	COG0641	radical SAM
AFK63_RS11350	COG0670	Belongs to the BI1 family
AFK63_RS11375	COG1832	CoA-binding protein
AFK63_RS11385	COG0210	DNA helicase
AFK63_RS11390	COG3304	Inner membrane component domain
AFK63_RS11395	COG1289	transmembrane transporter activity
AFK63_RS11400	COG3070	regulator of competence-specific genes
AFK63_RS11420	COG1067	ATP-dependent peptidase activity
AFK63_RS11430	COG3009	Protein conserved in bacteria
AFK63_RS11435	COG3008	intermembrane lipid transfer
AFK63_RS11435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AFK63_RS11440	COG2995	paraquat-inducible protein a
AFK63_RS11445	COG0488	(ABC) transporter
AFK63_RS11455	COG3217	Mosc domain protein beta barrel domain protein
AFK63_RS11455	COG0633	Ferredoxin
AFK63_RS11470	COG0431	NADPH-dependent FMN reductase
AFK63_RS11475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFK63_RS11485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFK63_RS11495	COG0308	aminopeptidase N
AFK63_RS11515	COG1448	Aminotransferase
AFK63_RS11520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFK63_RS11525	COG3108	Peptidase M15
AFK63_RS11530	COG2989	Protein conserved in bacteria
AFK63_RS11540	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AFK63_RS11550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFK63_RS11555	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AFK63_RS11560	COG3173	Aminoglycoside phosphotransferase
AFK63_RS11570	COG1522	sequence-specific DNA binding
AFK63_RS11585	COG3214	Protein conserved in bacteria
AFK63_RS11600	COG2333	competence protein COMEC
AFK63_RS11600	COG0658	competence protein
AFK63_RS11610	COG0539	negative regulation of cytoplasmic translation
AFK63_RS11615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFK63_RS11620	COG0501	Belongs to the peptidase M48B family
AFK63_RS11635	COG2323	membrane
AFK63_RS11640	COG1944	ATP diphosphatase activity
AFK63_RS11645	COG2116	formate transmembrane transporter activity
AFK63_RS11650	COG1882	Formate acetyltransferase
AFK63_RS11655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AFK63_RS11660	COG0477	Major facilitator Superfamily
AFK63_RS11670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFK63_RS11680	COG1674	ftsk spoiiie
AFK63_RS11680	COG1178	ABC-type Fe3 transport system permease component
AFK63_RS11690	COG0492	ferredoxin-NADP+ reductase activity
AFK63_RS11695	COG4988	ABC transporter
AFK63_RS11700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AFK63_RS11715	COG0542	response to heat
AFK63_RS11725	COG1278	Cold shock
AFK63_RS11735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFK63_RS11740	COG2990	Protein conserved in bacteria
AFK63_RS11745	COG3593	DNA synthesis involved in DNA repair
AFK63_RS11750	COG2431	L-lysine efflux transmembrane transporter activity
AFK63_RS11760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFK63_RS11770	COG0028	Belongs to the TPP enzyme family
AFK63_RS11775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AFK63_RS11780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFK63_RS11785	COG3023	N-Acetylmuramoyl-L-alanine amidase
AFK63_RS11800	COG1126	abc transporter atp-binding protein
AFK63_RS11805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFK63_RS11810	COG4215	(ABC) transporter
AFK63_RS11815	COG4160	amino acid transport
AFK63_RS11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFK63_RS11825	COG2207	Transcriptional regulator
AFK63_RS11835	COG2211	Major facilitator Superfamily
AFK63_RS11840	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AFK63_RS11855	COG1177	transmembrane transport
AFK63_RS11860	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFK63_RS11865	COG3842	ATPase activity
AFK63_RS11870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AFK63_RS11915	COG3226	Transcriptional regulator
AFK63_RS11920	COG0738	Major facilitator superfamily
AFK63_RS11930	COG0561	phosphatase activity
AFK63_RS11935	COG2814	Major facilitator Superfamily
AFK63_RS11945	COG0671	phosphoesterase, PA-phosphatase related
AFK63_RS11950	COG1349	DNA-binding transcription factor activity
AFK63_RS11955	COG1686	Belongs to the peptidase S11 family
AFK63_RS11960	COG0625	glutathione transferase activity
AFK63_RS11965	COG2133	pyrroloquinoline quinone binding
AFK63_RS11985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFK63_RS12030	COG0747	negative chemotaxis
AFK63_RS12040	COG0303	'Molybdopterin
AFK63_RS12045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFK63_RS12050	COG1609	Transcriptional regulator
AFK63_RS12055	COG2271	Major facilitator Superfamily
AFK63_RS12065	COG0488	(ABC) transporter
AFK63_RS12070	COG1376	ErfK ybiS ycfS ynhG family protein
AFK63_RS12080	COG2814	Major facilitator Superfamily
AFK63_RS12085	COG1566	PFAM secretion protein HlyD family protein
AFK63_RS12090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFK63_RS12095	COG1321	iron dependent repressor
AFK63_RS12100	COG2194	sulfuric ester hydrolase activity
AFK63_RS12105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AFK63_RS12120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFK63_RS12125	COG0765	amino acid transport
AFK63_RS12130	COG1126	abc transporter atp-binding protein
AFK63_RS12135	COG0668	transmembrane transport
AFK63_RS12150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFK63_RS12160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFK63_RS12170	COG3121	Chaperone
AFK63_RS12175	COG3188	usher protein
AFK63_RS12190	COG1199	ATP-dependent helicase activity
AFK63_RS12195	COG3711	transcriptional antiterminator
AFK63_RS12200	COG1263	PTS System
AFK63_RS12200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS12200	COG2190	(PTS) system
AFK63_RS12205	COG2723	6-phospho-beta-galactosidase activity
AFK63_RS12210	COG2723	6-phospho-beta-galactosidase activity
AFK63_RS12215	COG1486	melibiose metabolic process
AFK63_RS12220	COG1263	PTS System
AFK63_RS12220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS12225	COG2188	Transcriptional regulator
AFK63_RS12230	COG0513	Belongs to the DEAD box helicase family
AFK63_RS12240	COG3568	Endonuclease Exonuclease Phosphatase
AFK63_RS12245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFK63_RS12250	COG0392	lysyltransferase activity
AFK63_RS12255	COG0670	Belongs to the BI1 family
AFK63_RS12260	COG0314	molybdopterin synthase activity
AFK63_RS12265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AFK63_RS12275	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFK63_RS12300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFK63_RS12330	COG1881	PFAM PEBP family protein
AFK63_RS12335	COG4677	pectinesterase activity
AFK63_RS12345	COG0561	phosphatase activity
AFK63_RS12355	COG4149	molybdate abc transporter
AFK63_RS12360	COG0725	ABC transporter, periplasmic molybdate-binding protein
AFK63_RS12365	COG2005	Transcriptional regulator
AFK63_RS12365	COG3585	molybdate ion transport
AFK63_RS12370	COG1119	ATPase activity
AFK63_RS12380	COG1085	galactose-1-phosphate uridylyltransferase
AFK63_RS12390	COG2017	converts alpha-aldose to the beta-anomer
AFK63_RS12400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AFK63_RS12410	COG1230	cation diffusion facilitator family transporter
AFK63_RS12415	COG3201	nicotinamide mononucleotide transporter
AFK63_RS12420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFK63_RS12455	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AFK63_RS12460	COG2885	chlorophyll binding
AFK63_RS12470	COG3064	Membrane
AFK63_RS12475	COG0848	biopolymer transport protein
AFK63_RS12480	COG0811	peptide transport
AFK63_RS12485	COG0824	Thioesterase
AFK63_RS12490	COG3790	cyd operon protein YbgE
AFK63_RS12495	COG1294	oxidase, subunit
AFK63_RS12500	COG1271	oxidase subunit
AFK63_RS12505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFK63_RS12515	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFK63_RS12520	COG0567	Dehydrogenase, E1 component
AFK63_RS12525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFK63_RS12530	COG1053	succinate dehydrogenase
AFK63_RS12535	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AFK63_RS12540	COG2009	succinate dehydrogenase
AFK63_RS12545	COG0372	Belongs to the citrate synthase family
AFK63_RS12580	COG1984	allophanate hydrolase subunit 2
AFK63_RS12585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AFK63_RS12600	COG3272	Protein of unknown function (DUF1722)
AFK63_RS12615	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AFK63_RS12625	COG2205	protein histidine kinase activity
AFK63_RS12630	COG0745	RESPONSE REGULATOR receiver
AFK63_RS12635	COG1982	Orn Lys Arg decarboxylase major
AFK63_RS12640	COG0531	amino acid
AFK63_RS12645	COG0033	Phosphoglucomutase
AFK63_RS12655	COG0596	Alpha beta hydrolase
AFK63_RS12665	COG0716	FMN binding
AFK63_RS12670	COG0735	belongs to the Fur family
AFK63_RS12700	COG1263	PTS System
AFK63_RS12700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS12700	COG2190	(PTS) system
AFK63_RS12710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AFK63_RS12715	COG1846	Transcriptional regulator
AFK63_RS12715	COG1940	carbohydrate kinase activity
AFK63_RS12720	COG0647	UMP catabolic process
AFK63_RS12725	COG0367	asparagine synthase
AFK63_RS12765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFK63_RS12775	COG1702	phosphate starvation-inducible protein PhoH
AFK63_RS12800	COG0765	amino acid transport
AFK63_RS12805	COG0765	amino acid transport
AFK63_RS12810	COG1126	abc transporter atp-binding protein
AFK63_RS12825	COG2888	peptidyl-tyrosine sulfation
AFK63_RS12840	COG1466	dna polymerase III delta subunit
AFK63_RS12850	COG0799	negative regulation of ribosome biogenesis
AFK63_RS12860	COG0768	penicillin binding
AFK63_RS12865	COG0772	Belongs to the SEDS family
AFK63_RS12870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AFK63_RS12875	COG1686	Belongs to the peptidase S11 family
AFK63_RS12890	COG0583	DNA-binding transcription factor activity
AFK63_RS12905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFK63_RS12925	COG3069	C4-dicarboxylate transmembrane transporter activity
AFK63_RS12930	COG3719	Belongs to the RNase T2 family
AFK63_RS12940	COG0366	Alpha amylase catalytic
AFK63_RS12945	COG0366	Alpha amylase catalytic
AFK63_RS12950	COG3842	ATPase activity
AFK63_RS12965	COG1653	transport
AFK63_RS12975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFK63_RS12980	COG1063	alcohol dehydrogenase
AFK63_RS12985	COG0589	response to stress
AFK63_RS12990	COG3634	alkyl hydroperoxide reductase activity
AFK63_RS13000	COG0583	DNA-binding transcription factor activity
AFK63_RS13005	COG0436	Aminotransferase
AFK63_RS13025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFK63_RS13025	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AFK63_RS13030	COG3251	PFAM MbtH domain protein
AFK63_RS13035	COG2382	esterase
AFK63_RS13040	COG4771	TonB-dependent receptor
AFK63_RS13045	COG2977	Belongs to the P-Pant transferase superfamily
AFK63_RS13060	COG0840	transmembrane signaling receptor activity
AFK63_RS13065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK63_RS13070	COG0640	Transcriptional regulator
AFK63_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
AFK63_RS13100	COG0386	Belongs to the glutathione peroxidase family
AFK63_RS13115	COG2501	S4 domain
AFK63_RS13120	COG2190	(PTS) system
AFK63_RS13120	COG1263	PTS System
AFK63_RS13120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS13125	COG1609	Transcriptional regulator
AFK63_RS13135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFK63_RS13145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFK63_RS13150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AFK63_RS13155	COG0626	cystathionine gamma-synthase activity
AFK63_RS13165	COG2011	ABC-type metal ion transport system permease component
AFK63_RS13175	COG1464	Belongs to the NlpA lipoprotein family
AFK63_RS13180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AFK63_RS13185	COG4181	ATPase activity
AFK63_RS13190	COG2755	lipolytic protein G-D-S-L family
AFK63_RS13195	COG0300	oxidoreductase activity
AFK63_RS13200	COG3118	belongs to the thioredoxin family
AFK63_RS13205	COG0330	HflC and HflK could
AFK63_RS13210	COG1585	Membrane protein implicated in regulation of membrane protease activity
AFK63_RS13235	COG3735	TraB family
AFK63_RS13245	COG0737	Belongs to the 5'-nucleotidase family
AFK63_RS13255	COG4651	solute:proton antiporter activity
AFK63_RS13255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFK63_RS13260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFK63_RS13270	COG1929	Belongs to the glycerate kinase type-1 family
AFK63_RS13275	COG2610	gluconate transmembrane transporter activity
AFK63_RS13280	COG3835	regulator
AFK63_RS13315	COG2832	Protein of unknown function (DUF454)
AFK63_RS13320	COG3923	Primosomal replication protein n
AFK63_RS13325	COG1196	nuclear chromosome segregation
AFK63_RS13325	COG3264	Mechanosensitive ion channel
AFK63_RS13330	COG1309	transcriptional regulator
AFK63_RS13335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFK63_RS13340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFK63_RS13355	COG0110	maltose O-acetyltransferase activity
AFK63_RS13395	COG2011	ABC-type metal ion transport system permease component
AFK63_RS13400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AFK63_RS13405	COG0456	acetyltransferase
AFK63_RS13405	COG1214	PFAM Peptidase M22, glycoprotease
AFK63_RS13410	COG2364	Membrane
AFK63_RS13415	COG0436	Aminotransferase
AFK63_RS13430	COG3695	enzyme binding
AFK63_RS13435	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AFK63_RS13440	COG1946	Acyl-CoA thioesterase
AFK63_RS13445	COG0004	ammonium transporteR
AFK63_RS13450	COG0347	Belongs to the P(II) protein family
AFK63_RS13455	COG1132	(ABC) transporter
AFK63_RS13460	COG1132	(ABC) transporter
AFK63_RS13465	COG1522	sequence-specific DNA binding
AFK63_RS13500	COG4533	DNA binding
AFK63_RS13515	COG0824	Thioesterase
AFK63_RS13520	COG1555	photosystem II stabilization
AFK63_RS13525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFK63_RS13530	COG0776	regulation of translation
AFK63_RS13535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFK63_RS13555	COG0271	Belongs to the BolA IbaG family
AFK63_RS13560	COG3056	Lipoprotein
AFK63_RS13565	COG2223	nitrite transmembrane transporter activity
AFK63_RS13575	COG0443	Heat shock 70 kDa protein
AFK63_RS13580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFK63_RS13585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFK63_RS13590	COG1845	cytochrome c oxidase, subunit III
AFK63_RS13595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AFK63_RS13605	COG2814	Major facilitator Superfamily
AFK63_RS13615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AFK63_RS13635	COG0142	geranyltranstransferase activity
AFK63_RS13645	COG0667	Aldo Keto reductase
AFK63_RS13650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFK63_RS13655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFK63_RS13670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFK63_RS13670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFK63_RS13680	COG4238	major outer membrane lipoprotein
AFK63_RS13685	COG3248	Nucleoside-binding outer membrane protein
AFK63_RS13690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFK63_RS13695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFK63_RS13700	COG1862	Preprotein translocase
AFK63_RS13730	COG0366	Alpha amylase catalytic
AFK63_RS13740	COG1114	Component of the transport system for branched-chain amino acids
AFK63_RS13745	COG5002	protein histidine kinase activity
AFK63_RS13755	COG0420	3'-5' exonuclease activity
AFK63_RS13760	COG0419	ATPase involved in DNA repair
AFK63_RS13765	COG1940	carbohydrate kinase activity
AFK63_RS13780	COG4126	flavin adenine dinucleotide binding
AFK63_RS13795	COG3416	Protein conserved in bacteria
AFK63_RS13805	COG2323	membrane
AFK63_RS13815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFK63_RS13820	COG2814	Major facilitator Superfamily
AFK63_RS13830	COG2814	Major facilitator Superfamily
AFK63_RS13840	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFK63_RS13860	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AFK63_RS13870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFK63_RS13875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFK63_RS13885	COG1546	Belongs to the CinA family
AFK63_RS13890	COG0113	porphobilinogen synthase activity
AFK63_RS13905	COG2175	clavaminate synthase activity
AFK63_RS13910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFK63_RS13920	COG4521	taurine ABC transporter
AFK63_RS13925	COG2040	homocysteine
AFK63_RS13930	COG0833	amino acid
AFK63_RS13935	COG1271	oxidase subunit
AFK63_RS13950	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AFK63_RS13955	COG0531	amino acid
AFK63_RS13960	COG4303	Ethanolamine ammonia lyase large subunit
AFK63_RS13965	COG4302	ethanolamine ammonia-lyase activity
AFK63_RS13970	COG1560	Kdo2-lipid A biosynthetic process
AFK63_RS13975	COG1349	DNA-binding transcription factor activity
AFK63_RS13980	COG0494	nUDIX hydrolase
AFK63_RS13990	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AFK63_RS13995	COG1609	Transcriptional regulator
AFK63_RS14005	COG2211	Major facilitator Superfamily
AFK63_RS14015	COG0288	reversible hydration of carbon dioxide
AFK63_RS14020	COG0659	secondary active sulfate transmembrane transporter activity
AFK63_RS14025	COG0628	permease
AFK63_RS14030	COG4993	Dehydrogenase
AFK63_RS14035	COG0583	DNA-binding transcription factor activity
AFK63_RS14055	COG3479	Phenolic acid decarboxylase
AFK63_RS14060	COG3387	PFAM Glycoside hydrolase 15-related
AFK63_RS14065	COG1464	Belongs to the NlpA lipoprotein family
AFK63_RS14070	COG2011	ABC-type metal ion transport system permease component
AFK63_RS14085	COG2814	Major facilitator Superfamily
AFK63_RS14095	COG1082	Xylose isomerase domain protein TIM barrel
AFK63_RS14105	COG3962	Belongs to the TPP enzyme family
AFK63_RS14110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFK63_RS14120	COG3718	enzyme involved in inositol metabolism
AFK63_RS14145	COG2223	nitrite transmembrane transporter activity
AFK63_RS14175	COG2226	methyltransferase
AFK63_RS14180	COG1309	transcriptional regulator
AFK63_RS14185	COG0251	oxidation-reduction process
AFK63_RS14190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFK63_RS14245	COG0747	negative chemotaxis
AFK63_RS14250	COG2195	Cleaves the N-terminal amino acid of tripeptides
AFK63_RS14295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AFK63_RS14315	COG2195	Cleaves the N-terminal amino acid of tripeptides
AFK63_RS14325	COG3034	peptidoglycan biosynthetic process
AFK63_RS14330	COG0121	glutamine amidotransferase
AFK63_RS14345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFK63_RS14365	COG2226	methyltransferase
AFK63_RS14375	COG0741	lytic transglycosylase activity
AFK63_RS14375	COG1388	LysM domain
AFK63_RS14380	COG2226	methyltransferase
AFK63_RS14385	COG3021	interspecies interaction between organisms
AFK63_RS14390	COG2814	Major facilitator Superfamily
AFK63_RS14395	COG0583	DNA-binding transcription factor activity
AFK63_RS14400	COG0656	L-ascorbic acid biosynthetic process
AFK63_RS14435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFK63_RS14440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFK63_RS14445	COG2011	ABC-type metal ion transport system permease component
AFK63_RS14450	COG1464	Belongs to the NlpA lipoprotein family
AFK63_RS14460	COG1720	tRNA m6t6A37 methyltransferase activity
AFK63_RS14470	COG3015	lipoprotein NlpE involved in copper resistance
AFK63_RS14475	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFK63_RS14480	COG4681	YaeQ
AFK63_RS14490	COG4568	rho-dependent transcription termination
AFK63_RS14500	COG0037	tRNA processing
AFK63_RS14505	COG0346	lactoylglutathione lyase activity
AFK63_RS14510	COG1982	Orn Lys Arg decarboxylase major
AFK63_RS14565	COG0750	zinc metalloprotease
AFK63_RS14570	COG0575	Belongs to the CDS family
AFK63_RS14580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFK63_RS14625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFK63_RS14645	COG2860	membrane
AFK63_RS14665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFK63_RS14670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFK63_RS14675	COG1120	ATPase activity
AFK63_RS14680	COG4774	siderophore transport
AFK63_RS14685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFK63_RS14690	COG1643	Atp-dependent helicase
AFK63_RS14695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AFK63_RS14715	COG0617	tRNA 3'-terminal CCA addition
AFK63_RS14720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFK63_RS14740	COG0726	polysaccharide deacetylase
AFK63_RS14745	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK63_RS14750	COG0842	Transport permease protein
AFK63_RS14755	COG1131	(ABC) transporter
AFK63_RS14760	COG0288	reversible hydration of carbon dioxide
AFK63_RS14770	COG4993	Dehydrogenase
AFK63_RS14800	COG1203	CRISPR-associated helicase, Cas3
AFK63_RS14805	COG1518	maintenance of DNA repeat elements
AFK63_RS14835	COG1049	propionate catabolic process, 2-methylcitrate cycle
AFK63_RS14840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFK63_RS14845	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFK63_RS14850	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFK63_RS14855	COG2186	Transcriptional regulator
AFK63_RS14860	COG1113	amino acid transport
AFK63_RS14865	COG2211	Major facilitator Superfamily
AFK63_RS14870	COG3940	Belongs to the glycosyl hydrolase 43 family
AFK63_RS14875	COG3725	Membrane protein required for beta-lactamase induction
AFK63_RS14890	COG4969	Belongs to the N-Me-Phe pilin family
AFK63_RS14895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFK63_RS14900	COG1459	type II secretion system
AFK63_RS14905	COG0516	GMP reductase activity
AFK63_RS14925	COG0494	nUDIX hydrolase
AFK63_RS14945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFK63_RS14950	COG0849	cell division
AFK63_RS14975	COG0772	Belongs to the SEDS family
AFK63_RS14990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFK63_RS15000	COG0768	penicillin binding
AFK63_RS15020	COG1609	Transcriptional regulator
AFK63_RS15030	COG0028	Belongs to the TPP enzyme family
AFK63_RS15060	COG2814	Major facilitator Superfamily
AFK63_RS15070	COG4143	(ABC) transporter
AFK63_RS15075	COG1178	ABC-type Fe3 transport system permease component
AFK63_RS15085	COG0586	Pfam SNARE associated Golgi protein
AFK63_RS15090	COG4977	sequence-specific DNA binding
AFK63_RS15100	COG2160	L-arabinose isomerase activity
AFK63_RS15105	COG0235	Class ii aldolase
AFK63_RS15110	COG0417	DNA replication proofreading
AFK63_RS15120	COG0564	pseudouridine synthase activity
AFK63_RS15135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFK63_RS15165	COG1280	lysine exporter protein (LysE YggA)
AFK63_RS15195	COG0505	Belongs to the CarA family
AFK63_RS15205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFK63_RS15225	COG1047	Peptidyl-prolyl cis-trans
AFK63_RS15240	COG0196	riboflavin kinase activity
AFK63_RS15250	COG0583	DNA-binding transcription factor activity
AFK63_RS15295	COG1584	GPR1 FUN34 yaaH family protein
AFK63_RS15300	COG0477	Major facilitator Superfamily
AFK63_RS15305	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFK63_RS15315	COG1115	amino acid carrier protein
AFK63_RS15330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFK63_RS15340	COG0527	aspartate kinase activity
AFK63_RS15340	COG0460	homoserine dehydrogenase
AFK63_RS15345	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AFK63_RS15350	COG0745	RESPONSE REGULATOR receiver
AFK63_RS15355	COG4452	Inner membrane protein CreD
AFK63_RS15360	COG2205	protein histidine kinase activity
AFK63_RS15365	COG0745	RESPONSE REGULATOR receiver
AFK63_RS15370	COG3045	CreA protein
AFK63_RS15375	COG2207	Transcriptional regulator
AFK63_RS15375	COG3708	Transcriptional regulator
AFK63_RS15395	COG0741	lytic transglycosylase activity
AFK63_RS15400	COG0488	(ABC) transporter
AFK63_RS15430	COG1442	glycosyl transferase family 8
AFK63_RS15430	COG1216	Glycosyl transferase, family 2
AFK63_RS15465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFK63_RS15470	COG0560	Phosphoserine phosphatase
AFK63_RS15475	COG3726	membrane protein affecting hemolysin expression
AFK63_RS15505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AFK63_RS15510	COG0084	hydrolase, TatD family'
AFK63_RS15515	COG4667	esterase of the alpha-beta hydrolase superfamily
AFK63_RS15520	COG2823	Periplasmic or secreted lipoprotein
AFK63_RS15530	COG1011	Hydrolase
AFK63_RS15535	COG0456	acetyltransferase
AFK63_RS15540	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AFK63_RS15570	COG3706	GGDEF domain
AFK63_RS15575	COG4114	ferric iron reductase
AFK63_RS15580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AFK63_RS15585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFK63_RS15590	COG2197	response regulator
AFK63_RS15595	COG2197	response regulator
AFK63_RS15600	COG2966	Psort location CytoplasmicMembrane, score
AFK63_RS15610	COG1846	Transcriptional regulator
AFK63_RS15615	COG1764	response to oxidative stress
AFK63_RS15625	COG1484	DNA-dependent DNA replication
AFK63_RS15645	COG0840	transmembrane signaling receptor activity
AFK63_RS15660	COG0402	S-adenosylhomocysteine deaminase activity
AFK63_RS15670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AFK63_RS15675	COG2723	6-phospho-beta-galactosidase activity
AFK63_RS15680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS15680	COG1263	PTS System
AFK63_RS15685	COG1609	Transcriptional regulator
AFK63_RS15695	COG1566	PFAM secretion protein HlyD family protein
AFK63_RS15705	COG1609	Transcriptional regulator
AFK63_RS15715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFK63_RS15715	COG1263	PTS System
AFK63_RS15720	COG1874	Beta-galactosidase
AFK63_RS15725	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AFK63_RS15730	COG3833	ABC-type maltose transport systems, permease component
AFK63_RS15735	COG1175	transmembrane transport
AFK63_RS15740	COG2182	Extracellular solute-binding protein
AFK63_RS15755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFK63_RS15760	COG2733	membrane
AFK63_RS15770	COG3157	Type VI secretion system effector, Hcp
AFK63_RS15780	COG0371	Dehydrogenase
AFK63_RS15815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFK63_RS15820	COG2197	response regulator
AFK63_RS15860	COG1064	alcohol dehydrogenase
AFK63_RS15890	COG0795	lipopolysaccharide-transporting ATPase activity
AFK63_RS15895	COG0795	lipopolysaccharide-transporting ATPase activity
AFK63_RS15900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFK63_RS15905	COG2927	DNA polymerase III (CHI subunit)
AFK63_RS15910	COG0525	valine-tRNA ligase activity
AFK63_RS15915	COG4269	membrane
AFK63_RS15945	COG2731	YhcH YjgK YiaL family protein
AFK63_RS15950	COG2235	arginine
AFK63_RS15960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFK63_RS15965	COG1288	antiporter activity
AFK63_RS15970	COG1438	arginine binding
AFK63_RS15985	COG0251	oxidation-reduction process
AFK63_RS15990	COG1032	radical SAM domain protein
AFK63_RS15995	COG2375	cellular response to nickel ion
AFK63_RS16000	COG1695	Transcriptional regulator
AFK63_RS16005	COG0840	transmembrane signaling receptor activity
AFK63_RS16010	COG0840	transmembrane signaling receptor activity
AFK63_RS16015	COG3706	GGDEF domain
AFK63_RS16030	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFK63_RS16030	COG1902	pentaerythritol trinitrate reductase activity
AFK63_RS16040	COG1451	nucleotide metabolic process
AFK63_RS16045	COG2949	membrane
AFK63_RS16050	COG0673	inositol 2-dehydrogenase activity
AFK63_RS16070	COG2721	sulfolactate sulfo-lyase activity
AFK63_RS16080	COG2271	Major facilitator Superfamily
AFK63_RS16085	COG2186	Transcriptional regulator
AFK63_RS16090	COG0586	Pfam SNARE associated Golgi protein
AFK63_RS16100	COG1422	Protein of unknown function (DUF1090)
AFK63_RS16105	COG4575	ribosome binding
AFK63_RS16110	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AFK63_RS16120	COG2259	Doxx family
AFK63_RS16125	COG0435	Glutathione S-transferase
AFK63_RS16130	COG3152	Membrane
AFK63_RS16160	COG0583	DNA-binding transcription factor activity
AFK63_RS16165	COG1741	Belongs to the pirin family
AFK63_RS16185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK63_RS16190	COG3414	Phosphotransferase system galactitol-specific IIB component
AFK63_RS16195	COG3775	system Galactitol-specific IIC component
AFK63_RS16200	COG1063	alcohol dehydrogenase
AFK63_RS16210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AFK63_RS16215	COG3107	peptidoglycan biosynthetic process
AFK63_RS16225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFK63_RS16230	COG2823	Periplasmic or secreted lipoprotein
AFK63_RS16235	COG0701	Predicted permease
AFK63_RS16240	COG0702	epimerase
AFK63_RS16245	COG0693	protein deglycase activity
AFK63_RS16260	COG3153	acetyltransferase
AFK63_RS16265	COG3154	lipid carrier protein
AFK63_RS16270	COG0826	peptidase U32
AFK63_RS16275	COG0826	peptidase U32
AFK63_RS16280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFK63_RS16285	COG0814	amino acid
AFK63_RS16295	COG0513	Belongs to the DEAD box helicase family
AFK63_RS16330	COG0195	Participates in both transcription termination and antitermination
AFK63_RS16350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFK63_RS16360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFK63_RS16365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFK63_RS16375	COG1534	Rna-binding protein
AFK63_RS16380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFK63_RS16385	COG2027	D-alanyl-D-alanine carboxypeptidase
AFK63_RS16390	COG0745	RESPONSE REGULATOR receiver
AFK63_RS16395	COG0642	Histidine kinase
AFK63_RS16405	COG0697	spore germination
AFK63_RS16420	COG0142	geranyltranstransferase activity
AFK63_RS16425	COG3423	Transcriptional regulator
AFK63_RS16435	COG5007	Belongs to the BolA IbaG family
AFK63_RS16445	COG2854	intermembrane phospholipid transfer
AFK63_RS16450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AFK63_RS16455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFK63_RS16460	COG1127	ABC transporter
AFK63_RS16465	COG0530	calcium, potassium:sodium antiporter activity
AFK63_RS16475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AFK63_RS16480	COG3117	lipopolysaccharide transmembrane transporter activity
AFK63_RS16485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AFK63_RS16490	COG1137	ATPase activity
AFK63_RS16495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AFK63_RS16515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK63_RS16540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AFK63_RS16545	COG5002	protein histidine kinase activity
AFK63_RS16545	COG0784	Response regulator, receiver
AFK63_RS16545	COG2198	Histidine kinase
AFK63_RS16550	COG1242	4 iron, 4 sulfur cluster binding
AFK63_RS16560	COG0067	glutamate synthase
AFK63_RS16560	COG0069	glutamate synthase activity
AFK63_RS16560	COG0070	glutamate synthase
AFK63_RS16565	COG0493	'glutamate synthase
AFK63_RS16575	COG2969	positive regulation of protein catabolic process
AFK63_RS16580	COG0625	glutathione transferase activity
AFK63_RS16595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AFK63_RS16600	COG3105	Protein conserved in bacteria
AFK63_RS16605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFK63_RS16610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFK63_RS16635	COG2732	(Barnase) inhibitor
AFK63_RS16645	COG1289	transmembrane transporter activity
AFK63_RS16660	COG0583	DNA-binding transcription factor activity
AFK63_RS16665	COG0312	modulator of DNA gyrase
AFK63_RS16670	COG3164	Protein of unknown function
AFK63_RS16685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AFK63_RS16690	COG1792	Involved in formation and maintenance of cell shape
AFK63_RS16695	COG1077	Cell shape determining protein MreB Mrl
AFK63_RS16700	COG2200	EAL domain
AFK63_RS16700	COG2199	diguanylate cyclase activity
AFK63_RS16705	COG0604	alcohol dehydrogenase
AFK63_RS16720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFK63_RS16725	COG0511	ligase activity, forming carbon-carbon bonds
AFK63_RS16730	COG0439	Biotin carboxylase
AFK63_RS16735	COG3924	membrane
AFK63_RS16740	COG4145	pantothenate transmembrane transporter activity
AFK63_RS16770	COG1309	transcriptional regulator
AFK63_RS16775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFK63_RS16780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFK63_RS16790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFK63_RS16795	COG4597	amino acid ABC transporter
AFK63_RS16800	COG0765	amino acid transport
AFK63_RS16805	COG1126	abc transporter atp-binding protein
AFK63_RS16845	COG0151	Belongs to the GarS family
AFK63_RS16880	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AFK63_RS16895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFK63_RS16900	COG2104	thiamine diphosphate biosynthetic process
AFK63_RS16910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFK63_RS16920	COG1447	Phosphotransferase system cellobiose-specific component IIA
AFK63_RS16960	COG0250	Participates in transcription elongation, termination and antitermination
AFK63_RS16965	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFK63_RS17005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFK63_RS17045	COG1739	Uncharacterized protein family UPF0029
AFK63_RS17095	COG0805	protein transport
AFK63_RS17105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFK63_RS17125	COG1322	Protein conserved in bacteria
AFK63_RS17150	COG0583	DNA-binding transcription factor activity
AFK63_RS17155	COG0697	spore germination
AFK63_RS17160	COG0561	phosphatase activity
AFK63_RS17165	COG2267	carboxylic ester hydrolase activity
AFK63_RS17170	COG1280	lysine exporter protein (LysE YggA)
AFK63_RS17175	COG1280	lysine exporter protein (LysE YggA)
AFK63_RS17185	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AFK63_RS17215	COG0210	DNA helicase
AFK63_RS17220	COG1011	Hydrolase
AFK63_RS17265	COG2959	enzyme of heme biosynthesis
AFK63_RS17270	COG3071	HemY protein
AFK63_RS17320	COG2244	polysaccharide biosynthetic process
AFK63_RS17325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFK63_RS17330	COG0456	acetyltransferase
AFK63_RS17335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AFK63_RS17340	COG1088	dTDP-glucose 4,6-dehydratase activity
AFK63_RS17345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AFK63_RS17350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AFK63_RS17360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFK63_RS17365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AFK63_RS17370	COG3118	belongs to the thioredoxin family
AFK63_RS17385	COG0210	DNA helicase
AFK63_RS17400	COG0583	DNA-binding transcription factor activity
AFK63_RS17415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFK63_RS17420	COG3978	acetolactate synthase activity
AFK63_RS17430	COG0606	chelatase, subunit chli
AFK63_RS17435	COG3085	chromosome segregation
AFK63_RS17510	COG0583	DNA-binding transcription factor activity
AFK63_RS17530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFK63_RS17570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AFK63_RS17575	COG0527	aspartate kinase activity
AFK63_RS17575	COG0460	homoserine dehydrogenase
AFK63_RS17580	COG0626	cystathionine gamma-synthase activity
AFK63_RS17595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFK63_RS17600	COG1609	Transcriptional regulator
AFK63_RS17605	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AFK63_RS17610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AFK63_RS17620	COG1575	Belongs to the MenA family. Type 1 subfamily
AFK63_RS17635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFK63_RS17655	COG2186	Transcriptional regulator
AFK63_RS17665	COG2258	MOSC domain
AFK63_RS17670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AFK63_RS17685	COG4977	sequence-specific DNA binding
AFK63_RS17710	COG1129	ABC transporter
AFK63_RS17715	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFK63_RS17720	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFK63_RS17725	COG1454	alcohol dehydrogenase
AFK63_RS17735	COG2211	Major facilitator Superfamily
AFK63_RS17755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AFK63_RS17775	COG0243	molybdopterin cofactor binding
AFK63_RS17775	COG3383	formate dehydrogenase (NAD+) activity
AFK63_RS17780	COG3383	formate dehydrogenase (NAD+) activity
AFK63_RS17780	COG0243	molybdopterin cofactor binding
AFK63_RS17785	COG0437	4 iron, 4 sulfur cluster binding
AFK63_RS17790	COG2864	formate dehydrogenase
AFK63_RS17805	COG2211	Major facilitator Superfamily
AFK63_RS17820	COG1940	carbohydrate kinase activity
AFK63_RS17825	COG1454	alcohol dehydrogenase
AFK63_RS17830	COG3276	selenocysteine insertion sequence binding
AFK63_RS17840	COG0625	glutathione transferase activity
AFK63_RS17845	COG2213	PTS system mannitol-specific
AFK63_RS17845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFK63_RS17855	COG3722	fumarate hydratase activity
AFK63_RS17860	COG1494	fructose-1,6-bisphosphatase
AFK63_RS17870	COG3152	Membrane
AFK63_RS17880	COG0149	triose-phosphate isomerase activity
AFK63_RS18060	COG0515	serine threonine protein kinase
AFK63_RS18160	COG1360	Flagellar Motor Protein
AFK63_RS18190	COG2814	Major facilitator Superfamily
AFK63_RS18205	COG2149	membrane
AFK63_RS18215	COG0071	Belongs to the small heat shock protein (HSP20) family
AFK63_RS18225	COG5645	(Lipo)protein
AFK63_RS18230	COG0823	Involved in the tonB-independent uptake of proteins
AFK63_RS18235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFK63_RS18245	COG2271	Major facilitator Superfamily
AFK63_RS18255	COG0800	Aldolase
AFK63_RS18260	COG3734	2-keto-3-deoxy-galactonokinase
AFK63_RS18265	COG2186	Transcriptional regulator
AFK63_RS18270	COG0561	phosphatase activity
AFK63_RS18275	COG0187	DNA topoisomerase II activity
AFK63_RS18285	COG0592	DNA-directed DNA polymerase activity
AFK63_RS18325	COG0644	oxidoreductase
AFK63_RS18330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFK63_RS18335	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AFK63_RS18360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFK63_RS18360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AFK63_RS18400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AFK63_RS18420	COG2091	lysine biosynthetic process via aminoadipic acid
AFK63_RS18425	COG0431	NADPH-dependent FMN reductase
AFK63_RS18430	COG2252	PERMEase
AFK63_RS18435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFK63_RS18440	COG2382	esterase
AFK63_RS18445	COG0704	Plays a role in the regulation of phosphate uptake
AFK63_RS18450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFK63_RS18455	COG0581	inorganic phosphate transmembrane transporter activity
AFK63_RS18460	COG0573	inorganic phosphate transmembrane transporter activity
AFK63_RS18465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFK63_RS18525	COG3312	ion transport
AFK63_RS18540	COG0716	FMN binding
AFK63_RS18545	COG1522	sequence-specific DNA binding
AFK63_RS18575	COG1129	ABC transporter
AFK63_RS18580	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFK63_RS18590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFK63_RS18595	COG1609	Transcriptional regulator
AFK63_RS18600	COG0477	Major facilitator Superfamily
AFK63_RS18605	COG2186	Transcriptional regulator
AFK63_RS18630	COG1763	Mo-molybdopterin cofactor biosynthetic process
AFK63_RS18635	COG0746	molybdenum cofactor guanylyltransferase activity
AFK63_RS18640	COG3084	Protein conserved in bacteria
AFK63_RS18645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFK63_RS18655	COG0204	Acyl-transferase
AFK63_RS18675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFK63_RS18685	COG3852	Histidine kinase
AFK63_RS18705	COG2211	Major facilitator Superfamily
AFK63_RS18710	COG1501	Belongs to the glycosyl hydrolase 31 family
AFK63_RS18730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFK63_RS18735	COG1349	DNA-binding transcription factor activity
AFK63_RS18740	COG1011	Hydrolase
AFK63_RS18755	COG0456	acetyltransferase
AFK63_RS18760	COG2982	Protein involved in outer membrane biogenesis
AFK63_RS18765	COG2233	PERMEase
AFK63_RS18810	COG3121	Chaperone
AFK63_RS18815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFK63_RS18820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFK63_RS18825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFK63_RS18835	COG0194	GDP metabolic process
AFK63_RS18845	COG2860	membrane
AFK63_RS18850	COG1561	YicC-like family, N-terminal region
AFK63_RS18875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFK63_RS18885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFK63_RS18890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFK63_RS18910	COG1519	Transferase
AFK63_RS18920	COG1216	Glycosyl transferase, family 2
AFK63_RS18925	COG0438	transferase activity, transferring glycosyl groups
AFK63_RS18935	COG0859	PFAM glycosyl transferase family 9
AFK63_RS18940	COG0859	PFAM glycosyl transferase family 9
AFK63_RS18945	COG0859	PFAM glycosyl transferase family 9
AFK63_RS18955	COG0156	8-amino-7-oxononanoate synthase activity
AFK63_RS18965	COG2194	sulfuric ester hydrolase activity
AFK63_RS18970	COG3307	-O-antigen
AFK63_RS18975	COG0463	Glycosyl transferase, family 2
AFK63_RS18985	COG2861	carbohydrate metabolic process
AFK63_RS18990	COG4942	peptidase
AFK63_RS19000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFK63_RS19005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFK63_RS19025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFK63_RS19030	COG2205	protein histidine kinase activity
AFK63_RS19035	COG0745	RESPONSE REGULATOR receiver
AFK63_RS19040	COG3678	ATP-independent chaperone mediated protein folding
AFK63_RS19055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AFK63_RS19075	COG2351	hydroxyisourate hydrolase activity
AFK63_RS19080	COG0745	RESPONSE REGULATOR receiver
AFK63_RS19085	COG2205	protein histidine kinase activity
AFK63_RS19100	COG1064	alcohol dehydrogenase
AFK63_RS19115	COG0457	Tetratricopeptide repeat
AFK63_RS19115	COG0463	Glycosyl transferase, family 2
AFK63_RS19120	COG2080	2 iron, 2 sulfur cluster binding
AFK63_RS19125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AFK63_RS19130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFK63_RS19135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFK63_RS19140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFK63_RS19145	COG0667	Aldo Keto reductase
AFK63_RS19215	COG0582	viral genome integration into host DNA
AFK63_RS19225	COG2211	Major facilitator Superfamily
AFK63_RS19230	COG1501	Belongs to the glycosyl hydrolase 31 family
AFK63_RS19235	COG3977	Valine--pyruvate aminotransferase
AFK63_RS19240	COG0366	Alpha amylase catalytic
AFK63_RS19245	COG2992	FlgJ-related protein
AFK63_RS19250	COG1609	Transcriptional regulator
AFK63_RS19250	COG2207	Transcriptional regulator
AFK63_RS19255	COG4214	carbohydrate transport
AFK63_RS19265	COG4213	ABC transporter substrate-binding protein
AFK63_RS19275	COG1070	Carbohydrate kinase
AFK63_RS19280	COG1335	isochorismatase
AFK63_RS19290	COG3274	enterobacterial common antigen metabolic process
AFK63_RS19310	COG2944	sequence-specific DNA binding
AFK63_RS19330	COG3842	ATPase activity
AFK63_RS19335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFK63_RS19360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFK63_RS19370	COG1609	Transcriptional regulator
AFK63_RS19375	COG3443	Belongs to the bacterial solute-binding protein 9 family
AFK63_RS19380	COG2885	chlorophyll binding
AFK63_RS19385	COG0243	molybdopterin cofactor binding
AFK63_RS19390	COG0456	acetyltransferase
AFK63_RS19395	COG2818	Glycosylase
AFK63_RS19400	COG5571	outer membrane autotransporter
AFK63_RS19405	COG2223	nitrite transmembrane transporter activity
AFK63_RS19410	COG1764	response to oxidative stress
AFK63_RS19430	COG0747	negative chemotaxis
AFK63_RS19435	COG0601	transmembrane transport
AFK63_RS19440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFK63_RS19445	COG0444	Belongs to the ABC transporter superfamily
AFK63_RS19450	COG4608	Belongs to the ABC transporter superfamily
AFK63_RS19475	COG1192	Involved in chromosome partitioning
AFK63_RS19480	COG1215	transferase activity, transferring glycosyl groups
AFK63_RS19485	COG1215	transferase activity, transferring glycosyl groups
AFK63_RS19495	COG0457	Tetratricopeptide repeat
AFK63_RS19495	COG3118	belongs to the thioredoxin family
AFK63_RS19500	COG2200	EAL domain
AFK63_RS19500	COG2199	diguanylate cyclase activity
AFK63_RS19510	COG0612	Peptidase, M16
AFK63_RS19520	COG2200	EAL domain
AFK63_RS19525	COG2982	Protein involved in outer membrane biogenesis
AFK63_RS19530	COG0477	Major facilitator Superfamily
AFK63_RS19535	COG1295	ribonuclease BN
AFK63_RS19540	COG0583	DNA-binding transcription factor activity
AFK63_RS19550	COG3111	PFAM Bacterial OB fold (BOF) protein
AFK63_RS19570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFK63_RS19575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AFK63_RS19610	COG0306	phosphate transporter
AFK63_RS19615	COG2081	HI0933 family
AFK63_RS19625	COG0174	glutamine synthetase
AFK63_RS19630	COG0791	NLP P60 protein
AFK63_RS19635	COG0628	permease
AFK63_RS19650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AFK63_RS19660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFK63_RS19680	COG3714	YhhN family
AFK63_RS19690	COG3776	membrane
AFK63_RS19695	COG0742	ribosomal rna small subunit methyltransferase
AFK63_RS19700	COG0552	protein localization to endoplasmic reticulum
AFK63_RS19705	COG2884	Cell division ATP-binding protein ftsE
AFK63_RS19710	COG2177	Part of the ABC transporter FtsEX involved in
AFK63_RS19715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFK63_RS19725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFK63_RS19735	COG0683	leucine binding
AFK63_RS19745	COG0683	leucine binding
AFK63_RS19755	COG4177	L-phenylalanine transmembrane transporter activity
AFK63_RS19765	COG0410	ABC transporter
AFK63_RS19800	COG0584	glycerophosphoryl diester phosphodiesterase
AFK63_RS19810	COG0405	Gamma-glutamyltransferase
AFK63_RS19815	COG1247	-acetyltransferase
AFK63_RS19820	COG0673	inositol 2-dehydrogenase activity
AFK63_RS19825	COG1741	Belongs to the pirin family
AFK63_RS19830	COG1609	Transcriptional regulator
AFK63_RS19835	COG3265	gluconokinase activity
AFK63_RS19840	COG2610	gluconate transmembrane transporter activity
AFK63_RS19845	COG2095	MarC family integral membrane protein
AFK63_RS19875	COG0058	SHG alpha-glucan phosphorylase activity
AFK63_RS19885	COG2203	Gaf domain
AFK63_RS19885	COG3706	GGDEF domain
AFK63_RS19885	COG4251	negative regulation of phosphorylation
AFK63_RS19885	COG5001	Diguanylate cyclase
AFK63_RS19890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AFK63_RS19905	COG1349	DNA-binding transcription factor activity
AFK63_RS19915	COG0058	SHG alpha-glucan phosphorylase activity