locus-tag	class	description
HWB01_gp005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWB01_gp043	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWB01_gp057	COG0419	ATPase involved in DNA repair
HWB01_gp064	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWB01_gp065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWB01_gp067	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWB01_gp069	COG0322	excinuclease ABC activity
HWB01_gp136	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HWB01_gp141	COG1435	thymidine kinase activity
HWB01_gp154	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWB01_gp182	COG0494	nUDIX hydrolase
HWB01_gp256	COG1328	CTP reductase activity
HWB01_gp273	COG5301	cellulose 1,4-beta-cellobiosidase activity