locus-tag	class	description
ESA_RS00005	COG0051	transcription antitermination factor activity, RNA binding
ESA_RS00030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ESA_RS00110	COG0201	protein transport
ESA_RS00120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ESA_RS00145	COG0789	Transcriptional regulator
ESA_RS00175	COG0758	DNA mediated transformation
ESA_RS00185	COG0551	DNA topoisomerase type I activity
ESA_RS00205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ESA_RS00240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ESA_RS00245	COG2224	Isocitrate lyase
ESA_RS00260	COG1410	methionine synthase
ESA_RS00260	COG0646	methionine synthase
ESA_RS00265	COG1283	sodium-dependent phosphate transmembrane transporter activity
ESA_RS00280	COG4650	regulator
ESA_RS00295	COG1690	Belongs to the RtcB family
ESA_RS00300	COG3541	Predicted nucleotidyltransferase
ESA_RS00305	COG0527	aspartate kinase activity
ESA_RS00330	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ESA_RS00390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ESA_RS00400	COG0534	Mate efflux family protein
ESA_RS00405	COG3237	CsbD-like
ESA_RS00410	COG0735	belongs to the Fur family
ESA_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ESA_RS00450	COG1448	Aminotransferase
ESA_RS00455	COG2831	hemolysin activation secretion protein
ESA_RS00460	COG0432	Pfam Uncharacterised protein family UPF0047
ESA_RS00465	COG2315	Protein conserved in bacteria
ESA_RS00480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ESA_RS00485	COG0629	single-stranded DNA binding
ESA_RS00505	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ESA_RS00515	COG0789	Transcriptional regulator
ESA_RS00525	COG2252	PERMEase
ESA_RS00530	COG0025	NhaP-type Na H and K H
ESA_RS00535	COG0673	inositol 2-dehydrogenase activity
ESA_RS00540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESA_RS00545	COG3162	membrane
ESA_RS00555	COG1301	dicarboxylic acid transport
ESA_RS00570	COG0326	Molecular chaperone. Has ATPase activity
ESA_RS00585	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ESA_RS00590	COG2824	Alkylphosphonate utilization operon protein PhnA
ESA_RS00595	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ESA_RS00615	COG0625	glutathione transferase activity
ESA_RS00620	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ESA_RS00660	COG1309	transcriptional regulator
ESA_RS00675	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ESA_RS00680	COG1027	Aspartate ammonia-lyase
ESA_RS00685	COG3030	protein affecting phage T7 exclusion by the F plasmid
ESA_RS00705	COG1509	lysine 2,3-aminomutase activity
ESA_RS00715	COG5510	response to toxic substance
ESA_RS00730	COG3040	lipid binding
ESA_RS00745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ESA_RS00750	COG1053	succinate dehydrogenase
ESA_RS00760	COG1511	domain protein
ESA_RS00760	COG3264	Mechanosensitive ion channel
ESA_RS00800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ESA_RS00805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ESA_RS00805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ESA_RS00810	COG0802	atpase or kinase
ESA_RS00815	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESA_RS00835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ESA_RS00840	COG0330	HflC and HflK could
ESA_RS00845	COG0330	HflC and HflK could
ESA_RS00850	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ESA_RS00865	COG0557	exoribonuclease II activity
ESA_RS00870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESA_RS00875	COG3766	membrane
ESA_RS00880	COG5463	Belongs to the UPF0441 family
ESA_RS00885	COG0754	glutathionylspermidine amidase activity
ESA_RS00890	COG1960	acyl-CoA dehydrogenase activity
ESA_RS00905	COG3650	response to hydrogen peroxide
ESA_RS00910	COG1073	alpha beta
ESA_RS00925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ESA_RS00935	COG3061	Opacity-associated protein A
ESA_RS00945	COG0545	Peptidyl-prolyl cis-trans isomerase
ESA_RS00950	COG1113	amino acid transport
ESA_RS00960	COG0840	transmembrane signaling receptor activity
ESA_RS00965	COG0697	spore germination
ESA_RS00975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ESA_RS00975	COG2169	Transcriptional regulator
ESA_RS00985	COG0702	epimerase
ESA_RS00990	COG1733	regulation of RNA biosynthetic process
ESA_RS01000	COG1218	3'(2'),5'-bisphosphate nucleotidase
ESA_RS01005	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ESA_RS01015	COG1253	flavin adenine dinucleotide binding
ESA_RS01035	COG2911	Protein conserved in bacteria
ESA_RS01040	COG2105	PFAM AIG2 family protein
ESA_RS01045	COG0840	transmembrane signaling receptor activity
ESA_RS01055	COG1879	ABC-type sugar transport system periplasmic component
ESA_RS01060	COG1129	ABC transporter
ESA_RS01065	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESA_RS01070	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESA_RS01085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ESA_RS01100	COG0312	modulator of DNA gyrase
ESA_RS01105	COG3783	Cytochrome b(562)
ESA_RS01150	COG3711	transcriptional antiterminator
ESA_RS01150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS01155	COG3077	Addiction module antitoxin, RelB DinJ family
ESA_RS01160	COG2026	Addiction module toxin, RelE StbE family
ESA_RS01165	COG0602	queuosine metabolic process
ESA_RS01175	COG0583	DNA-binding transcription factor activity
ESA_RS01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
ESA_RS01185	COG0366	Alpha amylase catalytic
ESA_RS01190	COG1263	PTS System
ESA_RS01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS01200	COG1309	transcriptional regulator
ESA_RS01205	COG2999	glutathione oxidoreductase activity
ESA_RS01220	COG0656	L-ascorbic acid biosynthetic process
ESA_RS01225	COG1979	alcohol dehydrogenase
ESA_RS01230	COG2207	Transcriptional regulator
ESA_RS01235	COG0586	Pfam SNARE associated Golgi protein
ESA_RS01250	COG0848	biopolymer transport protein
ESA_RS01255	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS01260	COG1349	DNA-binding transcription factor activity
ESA_RS01285	COG0668	transmembrane transport
ESA_RS01290	COG4580	involved in the transport of maltose and maltodextrins
ESA_RS01295	COG1447	Phosphotransferase system cellobiose-specific component IIA
ESA_RS01300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESA_RS01310	COG1609	Transcriptional regulator
ESA_RS01315	COG3647	Membrane
ESA_RS01355	COG1696	Membrane protein involved in D-alanine export
ESA_RS01370	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
ESA_RS01385	COG5445	Predicted secreted protein (DUF2300)
ESA_RS01390	COG4676	Protein conserved in bacteria
ESA_RS01400	COG1811	Na channel or pump
ESA_RS01405	COG1982	Orn Lys Arg decarboxylase major
ESA_RS01420	COG3493	citrate carrier protein
ESA_RS01425	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESA_RS01455	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ESA_RS01470	COG1194	a g-specific adenine glycosylase
ESA_RS01480	COG3171	Protein conserved in bacteria
ESA_RS01505	COG0523	cobalamin synthesis protein
ESA_RS01510	COG2879	small protein
ESA_RS01515	COG1966	Carbon starvation protein
ESA_RS01565	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ESA_RS01600	COG0358	DNA primase activity
ESA_RS01605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ESA_RS01620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ESA_RS01635	COG4991	sh3 domain protein
ESA_RS01640	COG3025	triphosphatase activity
ESA_RS01655	COG2960	long-chain fatty acid transporting porin activity
ESA_RS01670	COG3384	dioxygenase
ESA_RS01675	COG0754	glutathionylspermidine amidase activity
ESA_RS01685	COG1538	Outer membrane efflux protein
ESA_RS01690	COG0494	nUDIX hydrolase
ESA_RS01695	COG3151	Protein conserved in bacteria
ESA_RS01700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ESA_RS01705	COG3150	esterase
ESA_RS01720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ESA_RS01725	COG2249	NAD(P)H dehydrogenase (quinone) activity
ESA_RS01735	COG0204	Acyl-transferase
ESA_RS01745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ESA_RS01760	COG0762	integral membrane protein
ESA_RS01765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ESA_RS01770	COG2805	Type II/IV secretion system protein
ESA_RS01800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ESA_RS01805	COG2356	endonuclease I
ESA_RS01815	COG2814	Major facilitator Superfamily
ESA_RS01825	COG1166	arginine decarboxylase activity
ESA_RS01835	COG0501	Belongs to the peptidase M48B family
ESA_RS01840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ESA_RS01860	COG0191	fructose-bisphosphate aldolase activity
ESA_RS01865	COG0668	transmembrane transport
ESA_RS01875	COG2968	Membrane
ESA_RS01890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ESA_RS01895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ESA_RS01905	COG3079	Belongs to the UPF0149 family
ESA_RS01910	COG0006	proline dipeptidase activity
ESA_RS01915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ESA_RS01920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ESA_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS01945	COG2723	6-phospho-beta-galactosidase activity
ESA_RS01950	COG1737	Transcriptional regulator
ESA_RS01960	COG1272	protein, Hemolysin III
ESA_RS01970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ESA_RS01980	COG0716	FMN binding
ESA_RS01995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ESA_RS02010	COG4942	peptidase
ESA_RS02030	COG0183	Belongs to the thiolase family
ESA_RS02040	COG0823	Involved in the tonB-independent uptake of proteins
ESA_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS02060	COG0395	ABC-type sugar transport system, permease component
ESA_RS02065	COG1175	transmembrane transport
ESA_RS02070	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ESA_RS02080	COG1794	racemase activity, acting on amino acids and derivatives
ESA_RS02085	COG0583	DNA-binding transcription factor activity
ESA_RS02095	COG1609	Transcriptional regulator
ESA_RS02100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESA_RS02105	COG2723	6-phospho-beta-galactosidase activity
ESA_RS02115	COG2186	Transcriptional regulator
ESA_RS02125	COG1609	Transcriptional regulator
ESA_RS02140	COG0667	Aldo Keto reductase
ESA_RS02150	COG0861	Integral membrane protein TerC family
ESA_RS02180	COG2165	general secretion pathway protein
ESA_RS02185	COG4795	General secretion pathway protein
ESA_RS02195	COG4967	type IV pilus modification protein PilV
ESA_RS02200	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ESA_RS02205	COG1025	Belongs to the peptidase M16 family
ESA_RS02210	COG1074	ATP-dependent DNA helicase activity
ESA_RS02215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESA_RS02220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ESA_RS02220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ESA_RS02225	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESA_RS02240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ESA_RS02245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ESA_RS02250	COG2166	iron-sulfur cluster assembly
ESA_RS02255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ESA_RS02265	COG0583	DNA-binding transcription factor activity
ESA_RS02270	COG2363	Small membrane protein
ESA_RS02285	COG1760	l-serine dehydratase
ESA_RS02290	COG0814	amino acid
ESA_RS02295	COG1611	Belongs to the LOG family
ESA_RS02310	COG3098	single-species biofilm formation
ESA_RS02315	COG0564	pseudouridine synthase activity
ESA_RS02320	COG0716	FMN binding
ESA_RS02325	COG3850	Histidine kinase
ESA_RS02325	COG2205	protein histidine kinase activity
ESA_RS02325	COG3437	response regulator, receiver
ESA_RS02325	COG4999	Histidine kinase
ESA_RS02335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ESA_RS02340	COG3956	TIGRFAM MazG family protein
ESA_RS02365	COG1263	PTS System
ESA_RS02365	COG2190	(PTS) system
ESA_RS02365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS02370	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ESA_RS02375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ESA_RS02380	COG0602	queuosine metabolic process
ESA_RS02385	COG0720	synthase
ESA_RS02405	COG2234	aminopeptidase activity
ESA_RS02500	COG0163	prenyltransferase activity
ESA_RS02505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ESA_RS02540	COG0765	amino acid transport
ESA_RS02545	COG1126	abc transporter atp-binding protein
ESA_RS02550	COG2951	lytic endotransglycosylase activity
ESA_RS02555	COG1546	Belongs to the CinA family
ESA_RS02575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ESA_RS02605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESA_RS02610	COG1238	metal cluster binding
ESA_RS02630	COG2814	Major facilitator Superfamily
ESA_RS02635	COG1566	PFAM secretion protein HlyD family protein
ESA_RS02640	COG1846	Transcriptional regulator
ESA_RS02650	COG2814	Major facilitator Superfamily
ESA_RS02665	COG4175	Glycine betaine
ESA_RS02675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESA_RS02690	COG4575	ribosome binding
ESA_RS02720	COG0840	transmembrane signaling receptor activity
ESA_RS02745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESA_RS02765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ESA_RS02770	COG0732	type I restriction modification DNA specificity domain
ESA_RS02780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ESA_RS02835	COG0582	viral genome integration into host DNA
ESA_RS02860	COG2867	negative regulation of translational initiation
ESA_RS02875	COG0497	DNA recombination
ESA_RS02890	COG4536	flavin adenine dinucleotide binding
ESA_RS02895	COG4137	Cytochrome C assembly protein
ESA_RS02900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ESA_RS02935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ESA_RS02940	COG1605	Chorismate mutase
ESA_RS02940	COG0287	Prephenate dehydrogenase
ESA_RS02950	COG0077	Prephenate dehydratase
ESA_RS02950	COG1605	Chorismate mutase
ESA_RS02955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ESA_RS02965	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ESA_RS02980	COG0542	response to heat
ESA_RS03010	COG1763	Mo-molybdopterin cofactor biosynthetic process
ESA_RS03020	COG0028	Belongs to the TPP enzyme family
ESA_RS03030	COG0477	Major facilitator Superfamily
ESA_RS03035	COG5544	Lipoprotein
ESA_RS03040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ESA_RS03050	COG3148	PFAM DTW domain containing protein
ESA_RS03055	COG3118	belongs to the thioredoxin family
ESA_RS03060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESA_RS03075	COG0513	Belongs to the DEAD box helicase family
ESA_RS03085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ESA_RS03105	COG3086	response to oxidative stress
ESA_RS03115	COG0681	Belongs to the peptidase S26 family
ESA_RS03145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ESA_RS03150	COG1737	Transcriptional regulator
ESA_RS03160	COG1263	PTS System
ESA_RS03160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS03165	COG0560	Phosphoserine phosphatase
ESA_RS03175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESA_RS03175	COG0047	phosphoribosylformylglycinamidine synthase activity
ESA_RS03180	COG2205	protein histidine kinase activity
ESA_RS03185	COG3170	Tfp pilus assembly protein FimV
ESA_RS03190	COG2204	response regulator
ESA_RS03195	COG0347	Belongs to the P(II) protein family
ESA_RS03210	COG0789	Transcriptional regulator
ESA_RS03220	COG2814	Major facilitator Superfamily
ESA_RS03225	COG3711	transcriptional antiterminator
ESA_RS03230	COG3683	transport system, periplasmic component
ESA_RS03235	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ESA_RS03260	COG0822	iron-sulfur transferase activity
ESA_RS03280	COG0633	Ferredoxin
ESA_RS03285	COG2975	iron-sulfur cluster assembly
ESA_RS03315	COG2897	thiosulfate sulfurtransferase activity
ESA_RS03330	COG2373	Large extracellular alpha-helical protein
ESA_RS03335	COG4953	penicillin-binding protein 1C
ESA_RS03365	COG2976	Protein conserved in bacteria
ESA_RS03380	COG1645	bacterial-type flagellum-dependent swarming motility
ESA_RS03400	COG0517	IMP dehydrogenase activity
ESA_RS03400	COG0516	GMP reductase activity
ESA_RS03415	COG2200	EAL domain
ESA_RS03430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ESA_RS03445	COG2233	PERMEase
ESA_RS03455	COG1393	Belongs to the ArsC family
ESA_RS03460	COG4783	chaperone-mediated protein folding
ESA_RS03465	COG0628	permease
ESA_RS03470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ESA_RS03475	COG2716	regulation of RNA biosynthetic process
ESA_RS03485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ESA_RS03495	COG2321	neutral zinc metallopeptidase
ESA_RS03505	COG0400	carboxylic ester hydrolase activity
ESA_RS03520	COG1393	Belongs to the ArsC family
ESA_RS03530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ESA_RS03535	COG2197	response regulator
ESA_RS03545	COG5342	invasion associated locus B
ESA_RS03565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ESA_RS03580	COG1120	ATPase activity
ESA_RS03585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESA_RS03590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESA_RS03600	COG4592	Periplasmic binding protein
ESA_RS03605	COG1169	isochorismate synthase
ESA_RS03610	COG1021	2,3-dihydroxybenzoate-AMP ligase
ESA_RS03615	COG3433	isochorismatase activity
ESA_RS03615	COG1535	isochorismatase
ESA_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS03630	COG1966	Carbon starvation protein
ESA_RS03635	COG2879	small protein
ESA_RS03655	COG0371	Dehydrogenase
ESA_RS03660	COG1129	ABC transporter
ESA_RS03665	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESA_RS03695	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESA_RS03705	COG3111	PFAM Bacterial OB fold (BOF) protein
ESA_RS03720	COG2837	iron assimilation
ESA_RS03725	COG4150	thiosulfate binding
ESA_RS03730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ESA_RS03735	COG4208	sulfate ABC transporter
ESA_RS03740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ESA_RS03745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ESA_RS03765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS03790	COG3530	Putative quorum-sensing-regulated virulence factor
ESA_RS03830	COG3415	Transposase
ESA_RS03845	COG2199	diguanylate cyclase activity
ESA_RS03845	COG2200	EAL domain
ESA_RS03850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ESA_RS03865	COG0667	Aldo Keto reductase
ESA_RS03870	COG3961	Belongs to the TPP enzyme family
ESA_RS03880	COG3279	Response regulator of the LytR AlgR family
ESA_RS03885	COG3275	phosphorelay sensor kinase activity
ESA_RS03895	COG0436	Aminotransferase
ESA_RS03905	COG0598	Magnesium transport protein CorA
ESA_RS03945	COG2116	formate transmembrane transporter activity
ESA_RS03955	COG4133	protoheme IX ABC transporter activity
ESA_RS03960	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESA_RS03965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESA_RS03970	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESA_RS03980	COG1138	Cytochrome C-type biogenesis protein
ESA_RS03990	COG3088	subunit of a heme lyase
ESA_RS03990	COG4235	cytochrome complex assembly
ESA_RS03995	COG4235	cytochrome complex assembly
ESA_RS03995	COG3088	subunit of a heme lyase
ESA_RS04005	COG2067	long-chain fatty acid transport protein
ESA_RS04010	COG3691	Protein conserved in bacteria
ESA_RS04025	COG2062	phosphohistidine phosphatase, SixA
ESA_RS04050	COG0730	response to heat
ESA_RS04055	COG3101	peptidyl-lysine hydroxylation
ESA_RS04070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESA_RS04090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ESA_RS04100	COG0586	Pfam SNARE associated Golgi protein
ESA_RS04110	COG0285	dihydrofolate synthase activity
ESA_RS04115	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ESA_RS04120	COG1286	toxin biosynthetic process
ESA_RS04125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ESA_RS04130	COG0163	prenyltransferase activity
ESA_RS04135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESA_RS04140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESA_RS04150	COG4160	amino acid transport
ESA_RS04155	COG4598	ABC transporter
ESA_RS04170	COG1090	epimerase
ESA_RS04175	COG0625	glutathione transferase activity
ESA_RS04180	COG0625	glutathione transferase activity
ESA_RS04185	COG0622	Phosphoesterase
ESA_RS04195	COG1309	transcriptional regulator
ESA_RS04230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESA_RS04235	COG0490	domain, Protein
ESA_RS04235	COG0471	metal ion transport
ESA_RS04245	COG0436	Aminotransferase
ESA_RS04250	COG0583	DNA-binding transcription factor activity
ESA_RS04275	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ESA_RS04295	COG0839	Belongs to the complex I subunit 6 family
ESA_RS04305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ESA_RS04310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESA_RS04325	COG2153	protein acetylation
ESA_RS04330	COG4575	ribosome binding
ESA_RS04335	COG1169	isochorismate synthase
ESA_RS04365	COG3647	Membrane
ESA_RS04405	COG2271	Major facilitator Superfamily
ESA_RS04410	COG0584	glycerophosphoryl diester phosphodiesterase
ESA_RS04415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ESA_RS04425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESA_RS04445	COG2197	response regulator
ESA_RS04450	COG0642	Histidine kinase
ESA_RS04450	COG2198	Histidine kinase
ESA_RS04460	COG1477	protein flavinylation
ESA_RS04465	COG2169	Transcriptional regulator
ESA_RS04465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ESA_RS04470	COG3145	DNA-N1-methyladenine dioxygenase activity
ESA_RS04475	COG4615	Cyclic peptide transporter
ESA_RS04480	COG0659	secondary active sulfate transmembrane transporter activity
ESA_RS04490	COG3121	Chaperone
ESA_RS04560	COG2267	carboxylic ester hydrolase activity
ESA_RS04560	COG2226	methyltransferase
ESA_RS04575	COG2974	May be involved in recombination
ESA_RS04585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ESA_RS04615	COG4725	Belongs to the MT-A70-like family
ESA_RS04625	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ESA_RS04630	COG3645	SOS response
ESA_RS04630	COG3646	Phage regulatory protein
ESA_RS04635	COG1403	HNH endonuclease
ESA_RS04640	COG0484	heat shock protein binding
ESA_RS04660	COG3179	chitinase
ESA_RS04685	COG4626	Terminase
ESA_RS04685	COG1802	Transcriptional regulator
ESA_RS04690	COG4695	Portal protein
ESA_RS04695	COG0740	serine-type endopeptidase activity
ESA_RS04795	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ESA_RS04805	COG3083	sulfuric ester hydrolase activity
ESA_RS04825	COG1061	Type III restriction enzyme res subunit
ESA_RS04830	COG1187	pseudouridine synthase activity
ESA_RS04835	COG2814	Major facilitator Superfamily
ESA_RS04845	COG4172	Belongs to the ABC transporter superfamily
ESA_RS04850	COG4239	(ABC) transporter, permease
ESA_RS04855	COG4174	ABC transporter (Permease)
ESA_RS04860	COG4166	transmembrane transport
ESA_RS04865	COG2200	EAL domain
ESA_RS04870	COG0791	NLP P60 protein
ESA_RS04875	COG0671	phosphoesterase, PA-phosphatase related
ESA_RS04880	COG0523	cobalamin synthesis protein
ESA_RS04885	COG0246	Mannitol dehydrogenase
ESA_RS04915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS04915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS04920	COG1105	Belongs to the carbohydrate kinase PfkB family
ESA_RS04925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESA_RS04925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ESA_RS04925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESA_RS04930	COG1082	Xylose isomerase domain protein TIM barrel
ESA_RS04930	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ESA_RS04940	COG2855	membrane
ESA_RS04945	COG0583	DNA-binding transcription factor activity
ESA_RS04950	COG0833	amino acid
ESA_RS04960	COG0477	Major facilitator Superfamily
ESA_RS04965	COG0302	gtp cyclohydrolase
ESA_RS04970	COG2311	Membrane
ESA_RS04980	COG1879	ABC-type sugar transport system periplasmic component
ESA_RS04985	COG1129	ABC transporter
ESA_RS04995	COG2949	membrane
ESA_RS05005	COG1346	cytolysis
ESA_RS05025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ESA_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS05045	COG0586	Pfam SNARE associated Golgi protein
ESA_RS05055	COG1686	Belongs to the peptidase S11 family
ESA_RS05065	COG0277	FAD linked oxidase domain protein
ESA_RS05070	COG1472	Belongs to the glycosyl hydrolase 3 family
ESA_RS05075	COG1732	Glycine betaine
ESA_RS05080	COG1174	glycine betaine transport
ESA_RS05085	COG1125	glycine betaine transport
ESA_RS05090	COG1174	glycine betaine transport
ESA_RS05100	COG0789	Transcriptional regulator
ESA_RS05110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESA_RS05125	COG1136	(ABC) transporter
ESA_RS05140	COG0489	protein tyrosine kinase activity
ESA_RS05150	COG3275	phosphorelay sensor kinase activity
ESA_RS05160	COG0840	transmembrane signaling receptor activity
ESA_RS05175	COG0488	(ABC) transporter
ESA_RS05180	COG5455	response to cobalt ion
ESA_RS05200	COG0351	phosphomethylpyrimidine kinase
ESA_RS05205	COG1830	Aldolase
ESA_RS05215	COG0826	peptidase U32
ESA_RS05220	COG0745	RESPONSE REGULATOR receiver
ESA_RS05225	COG2205	protein histidine kinase activity
ESA_RS05255	COG0443	Heat shock 70 kDa protein
ESA_RS05260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ESA_RS05265	COG5001	Diguanylate cyclase
ESA_RS05265	COG5002	protein histidine kinase activity
ESA_RS05265	COG3447	MASE1 domain protein
ESA_RS05280	COG2982	Protein involved in outer membrane biogenesis
ESA_RS05285	COG1253	flavin adenine dinucleotide binding
ESA_RS05305	COG0463	Glycosyl transferase, family 2
ESA_RS05310	COG1045	serine acetyltransferase
ESA_RS05315	COG0438	transferase activity, transferring glycosyl groups
ESA_RS05325	COG1216	Glycosyl transferase, family 2
ESA_RS05330	COG0110	maltose O-acetyltransferase activity
ESA_RS05335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ESA_RS05340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESA_RS05345	COG1051	belongs to the nudix hydrolase family
ESA_RS05350	COG0297	glycogen (starch) synthase activity
ESA_RS05355	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ESA_RS05355	COG0662	Cupin 2, conserved barrel domain protein
ESA_RS05360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESA_RS05365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ESA_RS05370	COG2244	polysaccharide biosynthetic process
ESA_RS05375	COG2327	Polysaccharide pyruvyl transferase
ESA_RS05380	COG0438	transferase activity, transferring glycosyl groups
ESA_RS05390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESA_RS05430	COG2244	polysaccharide biosynthetic process
ESA_RS05435	COG1215	transferase activity, transferring glycosyl groups
ESA_RS05455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ESA_RS05495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ESA_RS05500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ESA_RS05505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESA_RS05510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ESA_RS05515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ESA_RS05520	COG0531	amino acid
ESA_RS05525	COG2925	Exonuclease
ESA_RS05545	COG1289	transmembrane transporter activity
ESA_RS05560	COG0534	Mate efflux family protein
ESA_RS05590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ESA_RS05595	COG2200	EAL domain
ESA_RS05600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESA_RS05620	COG0477	Major facilitator Superfamily
ESA_RS05640	COG2203	Gaf domain
ESA_RS05640	COG3706	GGDEF domain
ESA_RS05640	COG4251	negative regulation of phosphorylation
ESA_RS05640	COG5001	Diguanylate cyclase
ESA_RS05645	COG0583	DNA-binding transcription factor activity
ESA_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS05665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ESA_RS05670	COG1418	mRNA catabolic process
ESA_RS05675	COG0270	DNA (cytosine-5-)-methyltransferase activity
ESA_RS05680	COG3727	T/G mismatch-specific endonuclease activity
ESA_RS05685	COG0697	spore germination
ESA_RS05690	COG2354	Protein conserved in bacteria
ESA_RS05695	COG5475	Uncharacterized small protein (DUF2158)
ESA_RS05720	COG2197	response regulator
ESA_RS05755	COG1580	Controls the rotational direction of flagella during chemotaxis
ESA_RS05770	COG1157	protein secretion by the type III secretion system
ESA_RS05775	COG1317	bacterial-type flagellum organization
ESA_RS05780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ESA_RS05800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESA_RS05810	COG0582	viral genome integration into host DNA
ESA_RS05830	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
ESA_RS05835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESA_RS05845	COG0702	epimerase
ESA_RS05855	COG2814	Major facilitator Superfamily
ESA_RS05860	COG0583	DNA-binding transcription factor activity
ESA_RS05865	COG2226	methyltransferase
ESA_RS05870	COG2135	peptidase activity
ESA_RS05875	COG0425	Belongs to the sulfur carrier protein TusA family
ESA_RS05900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ESA_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS05950	COG0318	PFAM AMP-dependent synthetase and ligase
ESA_RS05975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESA_RS05985	COG0765	amino acid transport
ESA_RS05990	COG1126	abc transporter atp-binding protein
ESA_RS05995	COG2197	response regulator
ESA_RS06005	COG2197	response regulator
ESA_RS06040	COG0814	amino acid
ESA_RS06045	COG1528	Iron-storage protein
ESA_RS06065	COG0477	Major facilitator Superfamily
ESA_RS06085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ESA_RS06090	COG1528	Iron-storage protein
ESA_RS06095	COG4297	protein containing double-stranded beta helix domain
ESA_RS06100	COG1879	ABC-type sugar transport system periplasmic component
ESA_RS06110	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESA_RS06125	COG0589	response to stress
ESA_RS06155	COG0835	chemotaxis
ESA_RS06205	COG0745	RESPONSE REGULATOR receiver
ESA_RS06235	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ESA_RS06250	COG3102	Protein conserved in bacteria
ESA_RS06265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ESA_RS06270	COG3142	Participates in the control of copper homeostasis
ESA_RS06275	COG0443	Heat shock 70 kDa protein
ESA_RS06280	COG2214	Heat shock protein DnaJ domain protein
ESA_RS06285	COG1652	LysM domain
ESA_RS06300	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ESA_RS06305	COG1801	Protein of unknown function DUF72
ESA_RS06310	COG1335	isochorismatase
ESA_RS06320	COG0494	nUDIX hydrolase
ESA_RS06345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ESA_RS06355	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ESA_RS06360	COG0739	heme binding
ESA_RS06365	COG1560	Kdo2-lipid A biosynthetic process
ESA_RS06370	COG0469	pyruvate kinase activity
ESA_RS06375	COG1737	Transcriptional regulator
ESA_RS06380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ESA_RS06385	COG0129	dihydroxy-acid dehydratase activity
ESA_RS06390	COG0800	Aldolase
ESA_RS06400	COG3141	response to X-ray
ESA_RS06410	COG2979	Protein of unknown function (DUF533)
ESA_RS06415	COG1770	oligopeptidase
ESA_RS06420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ESA_RS06430	COG2372	response to copper ion
ESA_RS06435	COG1276	copper resistance
ESA_RS06475	COG3008	intermembrane lipid transfer
ESA_RS06480	COG2995	paraquat-inducible protein a
ESA_RS06485	COG1956	GAF domain-containing protein
ESA_RS06505	COG1414	Transcriptional regulator
ESA_RS06535	COG2226	methyltransferase
ESA_RS06550	COG3716	PTS system mannose fructose sorbose family IID component
ESA_RS06555	COG3715	PTS system
ESA_RS06560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS06560	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS06565	COG1253	flavin adenine dinucleotide binding
ESA_RS06570	COG2200	EAL domain
ESA_RS06575	COG1760	l-serine dehydratase
ESA_RS06595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ESA_RS06600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESA_RS06630	COG3239	Fatty acid desaturase
ESA_RS06635	COG0251	oxidation-reduction process
ESA_RS06640	COG1199	ATP-dependent helicase activity
ESA_RS06645	COG1214	PFAM Peptidase M22, glycoprotease
ESA_RS06650	COG3065	identical protein binding
ESA_RS06655	COG0318	PFAM AMP-dependent synthetase and ligase
ESA_RS06670	COG2894	cell division
ESA_RS06685	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESA_RS06715	COG2719	SpoVR family
ESA_RS06725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ESA_RS06745	COG1619	proteins homologs of microcin C7 resistance protein MccF
ESA_RS06765	COG4774	siderophore transport
ESA_RS06780	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ESA_RS06790	COG2249	NAD(P)H dehydrogenase (quinone) activity
ESA_RS06805	COG3318	Belongs to the UPF0149 family
ESA_RS06805	COG3012	SEC-C Motif Domain Protein
ESA_RS06810	COG0012	GTP binding
ESA_RS06830	COG0659	secondary active sulfate transmembrane transporter activity
ESA_RS06860	COG2890	protein-(glutamine-N5) methyltransferase activity
ESA_RS06880	COG0387	Pfam Sodium calcium exchanger
ESA_RS06885	COG4572	Cation transport regulator
ESA_RS06890	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ESA_RS06900	COG0840	transmembrane signaling receptor activity
ESA_RS06905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ESA_RS06910	COG3707	response regulator
ESA_RS06915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESA_RS06920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESA_RS06925	COG1116	anion transmembrane transporter activity
ESA_RS06930	COG2146	nitrite reductase [NAD(P)H] activity
ESA_RS06930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ESA_RS06935	COG0243	molybdopterin cofactor binding
ESA_RS06945	COG4932	domain protein
ESA_RS06950	COG2197	response regulator
ESA_RS06955	COG3850	Histidine kinase
ESA_RS06960	COG2223	nitrite transmembrane transporter activity
ESA_RS06965	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ESA_RS06970	COG1140	nitrate reductase beta subunit
ESA_RS06975	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ESA_RS06980	COG2181	nitrate reductase activity
ESA_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS07005	COG0788	formyltetrahydrofolate deformylase activity
ESA_RS07015	COG0745	RESPONSE REGULATOR receiver
ESA_RS07020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ESA_RS07045	COG1454	alcohol dehydrogenase
ESA_RS07045	COG1012	belongs to the aldehyde dehydrogenase family
ESA_RS07050	COG2095	MarC family integral membrane protein
ESA_RS07060	COG0601	transmembrane transport
ESA_RS07065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESA_RS07070	COG0444	Belongs to the ABC transporter superfamily
ESA_RS07080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESA_RS07100	COG2350	Protein conserved in bacteria
ESA_RS07130	COG0727	PFAM Uncharacterised protein family (UPF0153)
ESA_RS07135	COG3047	cAMP biosynthetic process
ESA_RS07160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ESA_RS07160	COG0512	Glutamine amidotransferase of anthranilate synthase
ESA_RS07170	COG0613	PHP domain protein
ESA_RS07175	COG0009	L-threonylcarbamoyladenylate synthase
ESA_RS07185	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ESA_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS07195	COG0616	signal peptide processing
ESA_RS07225	COG0671	phosphoesterase, PA-phosphatase related
ESA_RS07230	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ESA_RS07235	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ESA_RS07245	COG0023	Translation Initiation Factor
ESA_RS07255	COG1349	DNA-binding transcription factor activity
ESA_RS07260	COG1882	Formate acetyltransferase
ESA_RS07265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ESA_RS07280	COG1024	Enoyl-CoA hydratase
ESA_RS07285	COG5001	Diguanylate cyclase
ESA_RS07295	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ESA_RS07295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ESA_RS07305	COG4172	Belongs to the ABC transporter superfamily
ESA_RS07315	COG4171	peptide transport system, permease
ESA_RS07330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ESA_RS07335	COG1842	Phage shock protein A
ESA_RS07345	COG1983	PspC domain protein
ESA_RS07355	COG0366	Alpha amylase catalytic
ESA_RS07360	COG1653	transport
ESA_RS07365	COG1175	transmembrane transport
ESA_RS07370	COG0395	ABC-type sugar transport system, permease component
ESA_RS07375	COG1063	alcohol dehydrogenase
ESA_RS07380	COG1082	Xylose isomerase domain protein TIM barrel
ESA_RS07385	COG0582	viral genome integration into host DNA
ESA_RS07425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ESA_RS07470	COG3772	lysozyme
ESA_RS07515	COG4626	Terminase
ESA_RS07515	COG1802	Transcriptional regulator
ESA_RS07560	COG3778	Protein conserved in bacteria
ESA_RS07580	COG0673	inositol 2-dehydrogenase activity
ESA_RS07585	COG1554	hydrolase, family 65, central catalytic
ESA_RS07590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESA_RS07600	COG1609	Transcriptional regulator
ESA_RS07605	COG3106	COG3106 Predicted ATPase
ESA_RS07625	COG4948	Mandelate Racemase Muconate Lactonizing
ESA_RS07630	COG2866	Carboxypeptidase
ESA_RS07635	COG4166	transmembrane transport
ESA_RS07655	COG3729	General stress protein
ESA_RS07660	COG3300	MHYT domain
ESA_RS07660	COG5001	Diguanylate cyclase
ESA_RS07695	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS07705	COG3284	Transcriptional regulator
ESA_RS07725	COG1013	pyruvate-flavodoxin oxidoreductase activity
ESA_RS07725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESA_RS07725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ESA_RS07725	COG0674	pyruvate-flavodoxin oxidoreductase activity
ESA_RS07730	COG3042	response to heat
ESA_RS07735	COG3187	Heat shock protein
ESA_RS07740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ESA_RS07745	COG2911	Protein conserved in bacteria
ESA_RS07755	COG3784	Protein of unknown function (DUF1318)
ESA_RS07770	COG1643	Atp-dependent helicase
ESA_RS07775	COG1943	Transposase
ESA_RS07780	COG4122	O-methyltransferase activity
ESA_RS07785	COG1538	Outer membrane efflux protein
ESA_RS07815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ESA_RS07820	COG1012	belongs to the aldehyde dehydrogenase family
ESA_RS07825	COG2755	lipolytic protein G-D-S-L family
ESA_RS07825	COG0657	acetylesterase activity
ESA_RS07830	COG3038	cytochrome b561
ESA_RS07835	COG0477	Major facilitator Superfamily
ESA_RS07855	COG0840	transmembrane signaling receptor activity
ESA_RS07860	COG3685	Protein conserved in bacteria
ESA_RS07865	COG1902	pentaerythritol trinitrate reductase activity
ESA_RS07870	COG0583	DNA-binding transcription factor activity
ESA_RS07875	COG5383	Protein conserved in bacteria
ESA_RS07890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ESA_RS07895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ESA_RS07900	COG0500	methyltransferase
ESA_RS07910	COG3135	benzoate transporter
ESA_RS07915	COG1396	sequence-specific DNA binding
ESA_RS07920	COG0826	peptidase U32
ESA_RS07950	COG3591	Belongs to the peptidase S1B family
ESA_RS07955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ESA_RS07960	COG2814	Major facilitator Superfamily
ESA_RS07965	COG0583	DNA-binding transcription factor activity
ESA_RS07970	COG1940	carbohydrate kinase activity
ESA_RS07975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ESA_RS08000	COG3136	membrane protein required for alginate biosynthesis
ESA_RS08005	COG3381	protein complex oligomerization
ESA_RS08010	COG3302	dmso reductase anchor subunit
ESA_RS08015	COG0437	4 iron, 4 sulfur cluster binding
ESA_RS08020	COG0243	molybdopterin cofactor binding
ESA_RS08035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ESA_RS08050	COG4948	Mandelate Racemase Muconate Lactonizing
ESA_RS08055	COG2271	Major facilitator Superfamily
ESA_RS08060	COG0246	Mannitol dehydrogenase
ESA_RS08075	COG1802	Transcriptional regulator
ESA_RS08080	COG4221	oxidoreductase activity
ESA_RS08085	COG0339	signal peptide processing
ESA_RS08095	COG3781	membrane
ESA_RS08100	COG3729	General stress protein
ESA_RS08110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ESA_RS08170	COG2801	Transposase and inactivated derivatives
ESA_RS08185	COG4245	von Willebrand factor, type A
ESA_RS08190	COG4245	von Willebrand factor, type A
ESA_RS08220	COG1358	cellular component organization or biogenesis
ESA_RS08280	COG2814	Major facilitator Superfamily
ESA_RS08285	COG0697	spore germination
ESA_RS08295	COG4977	sequence-specific DNA binding
ESA_RS08300	COG1846	Transcriptional regulator
ESA_RS08305	COG2814	Major facilitator Superfamily
ESA_RS08315	COG0039	L-malate dehydrogenase activity
ESA_RS08325	COG0583	DNA-binding transcription factor activity
ESA_RS08330	COG1012	belongs to the aldehyde dehydrogenase family
ESA_RS08335	COG0840	transmembrane signaling receptor activity
ESA_RS08350	COG2199	diguanylate cyclase activity
ESA_RS08360	COG5002	protein histidine kinase activity
ESA_RS08360	COG3447	MASE1 domain protein
ESA_RS08360	COG5001	Diguanylate cyclase
ESA_RS08385	COG3250	beta-galactosidase activity
ESA_RS08390	COG2205	protein histidine kinase activity
ESA_RS08390	COG0784	Response regulator, receiver
ESA_RS08390	COG5002	protein histidine kinase activity
ESA_RS08455	COG0456	acetyltransferase
ESA_RS08455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ESA_RS08470	COG0596	Alpha beta hydrolase
ESA_RS08475	COG0789	Transcriptional regulator
ESA_RS08480	COG0791	NLP P60 protein
ESA_RS08500	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ESA_RS08515	COG2207	Transcriptional regulator
ESA_RS08520	COG4221	oxidoreductase activity
ESA_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS08550	COG1064	alcohol dehydrogenase
ESA_RS08560	COG2207	Transcriptional regulator
ESA_RS08565	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ESA_RS08570	COG3685	Protein conserved in bacteria
ESA_RS08575	COG3546	catalase activity
ESA_RS08585	COG0778	Nitroreductase
ESA_RS08610	COG2175	clavaminate synthase activity
ESA_RS08615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ESA_RS08620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESA_RS08630	COG4772	TonB-dependent receptor
ESA_RS08635	COG3093	addiction module antidote protein HigA
ESA_RS08650	COG4221	oxidoreductase activity
ESA_RS08655	COG0840	transmembrane signaling receptor activity
ESA_RS08665	COG1802	Transcriptional regulator
ESA_RS08680	COG0601	transmembrane transport
ESA_RS08700	COG2130	NADP-dependent
ESA_RS08710	COG1247	-acetyltransferase
ESA_RS08715	COG3238	Protein conserved in bacteria
ESA_RS08720	COG2084	Dehydrogenase
ESA_RS08730	COG0747	negative chemotaxis
ESA_RS08760	COG0840	transmembrane signaling receptor activity
ESA_RS08770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ESA_RS08775	COG3302	dmso reductase anchor subunit
ESA_RS08780	COG0437	4 iron, 4 sulfur cluster binding
ESA_RS08785	COG0243	molybdopterin cofactor binding
ESA_RS08795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ESA_RS08825	COG1012	belongs to the aldehyde dehydrogenase family
ESA_RS08830	COG1177	transmembrane transport
ESA_RS08835	COG1176	ABC-type spermidine putrescine transport system, permease component I
ESA_RS08840	COG3842	ATPase activity
ESA_RS08845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ESA_RS08850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESA_RS08855	COG1271	oxidase subunit
ESA_RS08860	COG1294	oxidase, subunit
ESA_RS08870	COG2076	Multidrug Resistance protein
ESA_RS08875	COG2211	Major facilitator Superfamily
ESA_RS08890	COG0747	negative chemotaxis
ESA_RS08895	COG0601	transmembrane transport
ESA_RS08900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESA_RS08905	COG4172	Belongs to the ABC transporter superfamily
ESA_RS08910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESA_RS08920	COG0561	phosphatase activity
ESA_RS08925	COG2840	Smr protein MutS2
ESA_RS08930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ESA_RS08935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESA_RS08940	COG0589	response to stress
ESA_RS08945	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ESA_RS08950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ESA_RS08960	COG0531	amino acid
ESA_RS08970	COG0745	RESPONSE REGULATOR receiver
ESA_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS08985	COG2205	protein histidine kinase activity
ESA_RS08995	COG0114	fumarate hydratase activity
ESA_RS09010	COG5339	Protein conserved in bacteria
ESA_RS09020	COG3539	Fimbrial protein
ESA_RS09025	COG3539	Fimbrial protein
ESA_RS09040	COG3121	Chaperone
ESA_RS09045	COG3539	Fimbrial protein
ESA_RS09050	COG1609	Transcriptional regulator
ESA_RS09055	COG1263	PTS System
ESA_RS09055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS09060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ESA_RS09065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ESA_RS09070	COG0385	Bile acid
ESA_RS09075	COG0673	inositol 2-dehydrogenase activity
ESA_RS09120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ESA_RS09130	COG0625	glutathione transferase activity
ESA_RS09135	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ESA_RS09175	COG1566	PFAM secretion protein HlyD family protein
ESA_RS09180	COG1289	transmembrane transporter activity
ESA_RS09185	COG2032	superoxide dismutase activity
ESA_RS09190	COG4989	oxidoreductase activity
ESA_RS09195	COG3313	Fe-S protein
ESA_RS09205	COG1309	transcriptional regulator
ESA_RS09210	COG1902	pentaerythritol trinitrate reductase activity
ESA_RS09215	COG0346	lactoylglutathione lyase activity
ESA_RS09225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ESA_RS09230	COG0791	NLP P60 protein
ESA_RS09235	COG2814	Major facilitator Superfamily
ESA_RS09250	COG0583	DNA-binding transcription factor activity
ESA_RS09255	COG2814	Major facilitator Superfamily
ESA_RS09260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ESA_RS09265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESA_RS09270	COG2723	6-phospho-beta-galactosidase activity
ESA_RS09280	COG0307	riboflavin synthase, alpha
ESA_RS09375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ESA_RS09410	COG2814	Major facilitator Superfamily
ESA_RS09415	COG0583	DNA-binding transcription factor activity
ESA_RS09420	COG3383	formate dehydrogenase (NAD+) activity
ESA_RS09425	COG3383	formate dehydrogenase (NAD+) activity
ESA_RS09430	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ESA_RS09435	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ESA_RS09440	COG3383	formate dehydrogenase (NAD+) activity
ESA_RS09445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ESA_RS09455	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ESA_RS09465	COG3260	NADH ubiquinone oxidoreductase 20
ESA_RS09470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ESA_RS09475	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ESA_RS09475	COG3261	NADH dehydrogenase
ESA_RS09480	COG0650	Formate hydrogenlyase subunit 4
ESA_RS09485	COG0651	ATP synthesis coupled electron transport
ESA_RS09490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ESA_RS09500	COG0375	protein maturation
ESA_RS09505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ESA_RS09510	COG0298	carbon dioxide binding
ESA_RS09515	COG0409	Hydrogenase expression formation protein
ESA_RS09520	COG0309	Hydrogenase expression formation protein (HypE)
ESA_RS09525	COG3604	Transcriptional regulator
ESA_RS09530	COG0531	amino acid
ESA_RS09535	COG0174	glutamine synthetase
ESA_RS09540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ESA_RS09545	COG1396	sequence-specific DNA binding
ESA_RS09545	COG1917	Cupin 2, conserved barrel domain protein
ESA_RS09550	COG1012	belongs to the aldehyde dehydrogenase family
ESA_RS09555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESA_RS09560	COG3468	outer membrane autotransporter barrel domain protein
ESA_RS09560	COG3468	outer membrane autotransporter barrel domain protein
ESA_RS09580	COG1376	ErfK ybiS ycfS ynhG family protein
ESA_RS09595	COG0719	Fe-S assembly protein
ESA_RS09600	COG0396	ATPase activity
ESA_RS09605	COG0719	Fe-S assembly protein
ESA_RS09610	COG0316	Belongs to the HesB IscA family
ESA_RS09620	COG2050	protein possibly involved in aromatic compounds catabolism
ESA_RS09625	COG0247	lactate metabolic process
ESA_RS09625	COG0277	FAD linked oxidase domain protein
ESA_RS09630	COG0628	permease
ESA_RS09635	COG1472	Belongs to the glycosyl hydrolase 3 family
ESA_RS09640	COG2211	Major facilitator Superfamily
ESA_RS09645	COG0574	Belongs to the PEP-utilizing enzyme family
ESA_RS09645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ESA_RS09655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ESA_RS09670	COG1609	Transcriptional regulator
ESA_RS09675	COG1486	melibiose metabolic process
ESA_RS09680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESA_RS09685	COG0791	NLP P60 protein
ESA_RS09695	COG0386	Belongs to the glutathione peroxidase family
ESA_RS09700	COG4139	cobalamin transport
ESA_RS09740	COG0456	acetyltransferase
ESA_RS09780	COG3137	Salt-induced outer membrane protein
ESA_RS09785	COG1105	Belongs to the carbohydrate kinase PfkB family
ESA_RS09795	COG3001	Fructosamine kinase
ESA_RS09805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESA_RS09810	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS09815	COG1988	membrane-bound metal-dependent
ESA_RS09820	COG1823	symporter activity
ESA_RS09825	COG3093	addiction module antidote protein HigA
ESA_RS09840	COG0753	catalase activity
ESA_RS09845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ESA_RS09860	COG0322	excinuclease ABC activity
ESA_RS09870	COG3678	ATP-independent chaperone mediated protein folding
ESA_RS09900	COG0708	Exodeoxyribonuclease III
ESA_RS09905	COG0494	nUDIX hydrolase
ESA_RS09915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESA_RS09925	COG0778	Nitroreductase
ESA_RS09930	COG0616	signal peptide processing
ESA_RS09935	COG0252	asparaginase activity
ESA_RS09940	COG1335	isochorismatase
ESA_RS09945	COG3139	Protein of unknown function (DUF1315)
ESA_RS09955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ESA_RS09965	COG3713	MltA-interacting MipA family protein
ESA_RS09970	COG2766	serine protein kinase
ESA_RS09975	COG2718	Belongs to the UPF0229 family
ESA_RS09985	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ESA_RS09990	COG3729	General stress protein
ESA_RS09995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESA_RS10010	COG2807	transmembrane transport
ESA_RS10015	COG0504	CTP synthase activity
ESA_RS10020	COG3189	MarR family transcriptional regulator
ESA_RS10035	COG2990	Protein conserved in bacteria
ESA_RS10045	COG0784	Response regulator, receiver
ESA_RS10045	COG0835	chemotaxis
ESA_RS10060	COG1278	Cold shock
ESA_RS10065	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ESA_RS10075	COG0840	transmembrane signaling receptor activity
ESA_RS10095	COG0583	DNA-binding transcription factor activity
ESA_RS10115	COG0538	isocitrate dehydrogenase activity
ESA_RS10120	COG1187	pseudouridine synthase activity
ESA_RS10130	COG0840	transmembrane signaling receptor activity
ESA_RS10145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ESA_RS10155	COG2205	protein histidine kinase activity
ESA_RS10160	COG2850	peptidyl-arginine hydroxylation
ESA_RS10180	COG1177	transmembrane transport
ESA_RS10185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ESA_RS10200	COG4591	ABC-type transport system involved in lipoprotein release permease component
ESA_RS10210	COG4591	ABC-type transport system involved in lipoprotein release permease component
ESA_RS10215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ESA_RS10220	COG1388	LysM domain
ESA_RS10220	COG1376	ErfK ybiS ycfS ynhG family protein
ESA_RS10230	COG1309	transcriptional regulator
ESA_RS10235	COG3134	Outer membrane lipoprotein
ESA_RS10240	COG1252	NADH dehydrogenase
ESA_RS10255	COG0510	thiamine kinase activity
ESA_RS10265	COG5633	Lipoprotein
ESA_RS10270	COG0537	adenosine 5'-monophosphoramidase activity
ESA_RS10275	COG4773	Receptor
ESA_RS10280	COG1263	PTS System
ESA_RS10280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS10285	COG0084	hydrolase, TatD family'
ESA_RS10290	COG0470	DNA polymerase III
ESA_RS10300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ESA_RS10305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ESA_RS10310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESA_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS10350	COG0424	maF-like protein
ESA_RS10360	COG0564	pseudouridine synthase activity
ESA_RS10365	COG1530	ribonuclease E activity
ESA_RS10375	COG2814	Major facilitator Superfamily
ESA_RS10380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ESA_RS10385	COG1256	bacterial-type flagellum assembly
ESA_RS10405	COG4786	Flagellar basal body rod
ESA_RS10420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ESA_RS10425	COG1558	bacterial-type flagellum-dependent cell motility
ESA_RS10430	COG1815	bacterial-type flagellum-dependent cell motility
ESA_RS10450	COG0728	peptidoglycan biosynthetic process
ESA_RS10455	COG0673	inositol 2-dehydrogenase activity
ESA_RS10465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ESA_RS10475	COG2999	glutathione oxidoreductase activity
ESA_RS10505	COG3038	cytochrome b561
ESA_RS10520	COG1560	Kdo2-lipid A biosynthetic process
ESA_RS10530	COG5645	(Lipo)protein
ESA_RS10550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ESA_RS10570	COG3381	protein complex oligomerization
ESA_RS10695	COG2199	diguanylate cyclase activity
ESA_RS10695	COG2200	EAL domain
ESA_RS10770	COG3188	usher protein
ESA_RS10790	COG0243	molybdopterin cofactor binding
ESA_RS10800	COG1702	phosphate starvation-inducible protein PhoH
ESA_RS10810	COG2822	iron ion transport
ESA_RS10820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ESA_RS10830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESA_RS10835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ESA_RS10835	COG0506	proline dehydrogenase activity
ESA_RS10835	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ESA_RS10850	COG1309	transcriptional regulator
ESA_RS10885	COG2233	PERMEase
ESA_RS10890	COG3729	General stress protein
ESA_RS10935	COG4166	transmembrane transport
ESA_RS10940	COG0670	Belongs to the BI1 family
ESA_RS10965	COG1832	CoA-binding protein
ESA_RS10975	COG0210	DNA helicase
ESA_RS10980	COG3304	Inner membrane component domain
ESA_RS10985	COG1289	transmembrane transporter activity
ESA_RS10990	COG3070	regulator of competence-specific genes
ESA_RS11010	COG1067	ATP-dependent peptidase activity
ESA_RS11020	COG3009	Protein conserved in bacteria
ESA_RS11025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ESA_RS11025	COG3008	intermembrane lipid transfer
ESA_RS11030	COG2995	paraquat-inducible protein a
ESA_RS11035	COG0488	(ABC) transporter
ESA_RS11045	COG0633	Ferredoxin
ESA_RS11045	COG3217	Mosc domain protein beta barrel domain protein
ESA_RS11060	COG0431	NADPH-dependent FMN reductase
ESA_RS11065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESA_RS11075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESA_RS11080	COG1116	anion transmembrane transporter activity
ESA_RS11085	COG0308	aminopeptidase N
ESA_RS11105	COG1448	Aminotransferase
ESA_RS11110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESA_RS11115	COG3108	Peptidase M15
ESA_RS11120	COG2989	Protein conserved in bacteria
ESA_RS11130	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ESA_RS11140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ESA_RS11145	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ESA_RS11150	COG3173	Aminoglycoside phosphotransferase
ESA_RS11160	COG1522	sequence-specific DNA binding
ESA_RS11175	COG3214	Protein conserved in bacteria
ESA_RS11190	COG2333	competence protein COMEC
ESA_RS11190	COG0658	competence protein
ESA_RS11200	COG0539	negative regulation of cytoplasmic translation
ESA_RS11205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ESA_RS11220	COG2323	membrane
ESA_RS11225	COG1944	ATP diphosphatase activity
ESA_RS11230	COG2116	formate transmembrane transporter activity
ESA_RS11235	COG1882	Formate acetyltransferase
ESA_RS11240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ESA_RS11245	COG0477	Major facilitator Superfamily
ESA_RS11255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ESA_RS11275	COG0492	ferredoxin-NADP+ reductase activity
ESA_RS11280	COG4988	ABC transporter
ESA_RS11285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ESA_RS11300	COG0542	response to heat
ESA_RS11310	COG1278	Cold shock
ESA_RS11320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESA_RS11325	COG2990	Protein conserved in bacteria
ESA_RS11330	COG3593	DNA synthesis involved in DNA repair
ESA_RS11335	COG2431	L-lysine efflux transmembrane transporter activity
ESA_RS11345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ESA_RS11350	COG0028	Belongs to the TPP enzyme family
ESA_RS11355	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ESA_RS11360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESA_RS11365	COG3023	N-Acetylmuramoyl-L-alanine amidase
ESA_RS11380	COG1126	abc transporter atp-binding protein
ESA_RS11385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESA_RS11390	COG4215	(ABC) transporter
ESA_RS11395	COG4160	amino acid transport
ESA_RS11400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESA_RS11415	COG1177	transmembrane transport
ESA_RS11420	COG1176	ABC-type spermidine putrescine transport system, permease component I
ESA_RS11425	COG3842	ATPase activity
ESA_RS11430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ESA_RS11465	COG3226	Transcriptional regulator
ESA_RS11470	COG0738	Major facilitator superfamily
ESA_RS11480	COG0561	phosphatase activity
ESA_RS11485	COG2814	Major facilitator Superfamily
ESA_RS11495	COG0671	phosphoesterase, PA-phosphatase related
ESA_RS11500	COG1349	DNA-binding transcription factor activity
ESA_RS11505	COG1686	Belongs to the peptidase S11 family
ESA_RS11510	COG0625	glutathione transferase activity
ESA_RS11515	COG2133	pyrroloquinoline quinone binding
ESA_RS11535	COG0747	negative chemotaxis
ESA_RS11545	COG0303	'Molybdopterin
ESA_RS11550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ESA_RS11555	COG1609	Transcriptional regulator
ESA_RS11560	COG2271	Major facilitator Superfamily
ESA_RS11570	COG3210	domain, Protein
ESA_RS11575	COG0488	(ABC) transporter
ESA_RS11580	COG1376	ErfK ybiS ycfS ynhG family protein
ESA_RS11590	COG2814	Major facilitator Superfamily
ESA_RS11595	COG1566	PFAM secretion protein HlyD family protein
ESA_RS11600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ESA_RS11605	COG1321	iron dependent repressor
ESA_RS11610	COG2194	sulfuric ester hydrolase activity
ESA_RS11615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ESA_RS11630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESA_RS11635	COG0765	amino acid transport
ESA_RS11640	COG1126	abc transporter atp-binding protein
ESA_RS11645	COG0668	transmembrane transport
ESA_RS11655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ESA_RS11660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ESA_RS11670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ESA_RS11675	COG3539	Fimbrial protein
ESA_RS11680	COG3121	Chaperone
ESA_RS11700	COG1199	ATP-dependent helicase activity
ESA_RS11705	COG3711	transcriptional antiterminator
ESA_RS11710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS11710	COG1263	PTS System
ESA_RS11710	COG2190	(PTS) system
ESA_RS11715	COG2723	6-phospho-beta-galactosidase activity
ESA_RS11720	COG2723	6-phospho-beta-galactosidase activity
ESA_RS11725	COG0513	Belongs to the DEAD box helicase family
ESA_RS11730	COG1309	transcriptional regulator
ESA_RS11735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESA_RS11740	COG1131	(ABC) transporter
ESA_RS11745	COG0842	Transport permease protein
ESA_RS11750	COG0842	Transport permease protein
ESA_RS11760	COG3568	Endonuclease Exonuclease Phosphatase
ESA_RS11770	COG0392	lysyltransferase activity
ESA_RS11775	COG0670	Belongs to the BI1 family
ESA_RS11785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ESA_RS11795	COG0521	Mo-molybdopterin cofactor biosynthetic process
ESA_RS11825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ESA_RS11855	COG1881	PFAM PEBP family protein
ESA_RS11860	COG4677	pectinesterase activity
ESA_RS11870	COG0561	phosphatase activity
ESA_RS11880	COG4149	molybdate abc transporter
ESA_RS11885	COG0725	ABC transporter, periplasmic molybdate-binding protein
ESA_RS11895	COG2005	Transcriptional regulator
ESA_RS11895	COG3585	molybdate ion transport
ESA_RS11900	COG1119	ATPase activity
ESA_RS11910	COG1085	galactose-1-phosphate uridylyltransferase
ESA_RS11920	COG2017	converts alpha-aldose to the beta-anomer
ESA_RS11930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ESA_RS11940	COG1230	cation diffusion facilitator family transporter
ESA_RS11945	COG3201	nicotinamide mononucleotide transporter
ESA_RS11980	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ESA_RS11985	COG2885	chlorophyll binding
ESA_RS11995	COG3064	Membrane
ESA_RS12000	COG0848	biopolymer transport protein
ESA_RS12005	COG0811	peptide transport
ESA_RS12010	COG0824	Thioesterase
ESA_RS12015	COG3790	cyd operon protein YbgE
ESA_RS12020	COG1294	oxidase, subunit
ESA_RS12025	COG1271	oxidase subunit
ESA_RS12030	COG0383	alpha-mannosidase activity
ESA_RS12035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESA_RS12035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS12035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESA_RS12040	COG2188	Transcriptional regulator
ESA_RS12045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ESA_RS12055	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESA_RS12060	COG0567	Dehydrogenase, E1 component
ESA_RS12065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ESA_RS12070	COG1053	succinate dehydrogenase
ESA_RS12075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ESA_RS12085	COG0372	Belongs to the citrate synthase family
ESA_RS12120	COG1984	allophanate hydrolase subunit 2
ESA_RS12125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ESA_RS12130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ESA_RS12135	COG0415	Belongs to the DNA photolyase family
ESA_RS12140	COG3272	Protein of unknown function (DUF1722)
ESA_RS12160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ESA_RS12170	COG2205	protein histidine kinase activity
ESA_RS12175	COG0745	RESPONSE REGULATOR receiver
ESA_RS12180	COG1982	Orn Lys Arg decarboxylase major
ESA_RS12185	COG0531	amino acid
ESA_RS12190	COG0033	Phosphoglucomutase
ESA_RS12200	COG0596	Alpha beta hydrolase
ESA_RS12210	COG0716	FMN binding
ESA_RS12215	COG0735	belongs to the Fur family
ESA_RS12245	COG1263	PTS System
ESA_RS12245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS12245	COG2190	(PTS) system
ESA_RS12255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ESA_RS12260	COG1846	Transcriptional regulator
ESA_RS12260	COG1940	carbohydrate kinase activity
ESA_RS12265	COG0647	UMP catabolic process
ESA_RS12270	COG0367	asparagine synthase
ESA_RS12310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ESA_RS12320	COG1702	phosphate starvation-inducible protein PhoH
ESA_RS12335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ESA_RS12345	COG0765	amino acid transport
ESA_RS12350	COG0765	amino acid transport
ESA_RS12355	COG1126	abc transporter atp-binding protein
ESA_RS12360	COG2888	peptidyl-tyrosine sulfation
ESA_RS12375	COG1466	dna polymerase III delta subunit
ESA_RS12385	COG0799	negative regulation of ribosome biogenesis
ESA_RS12395	COG0768	penicillin binding
ESA_RS12400	COG0772	Belongs to the SEDS family
ESA_RS12405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ESA_RS12410	COG1686	Belongs to the peptidase S11 family
ESA_RS12425	COG0583	DNA-binding transcription factor activity
ESA_RS12440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ESA_RS12460	COG3069	C4-dicarboxylate transmembrane transporter activity
ESA_RS12465	COG3719	Belongs to the RNase T2 family
ESA_RS12475	COG0366	Alpha amylase catalytic
ESA_RS12480	COG0366	Alpha amylase catalytic
ESA_RS12485	COG3842	ATPase activity
ESA_RS12500	COG1653	transport
ESA_RS12510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ESA_RS12515	COG1063	alcohol dehydrogenase
ESA_RS12520	COG0589	response to stress
ESA_RS12525	COG3634	alkyl hydroperoxide reductase activity
ESA_RS12535	COG0583	DNA-binding transcription factor activity
ESA_RS12540	COG0436	Aminotransferase
ESA_RS12560	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ESA_RS12560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ESA_RS12565	COG3251	PFAM MbtH domain protein
ESA_RS12570	COG2382	esterase
ESA_RS12575	COG4771	TonB-dependent receptor
ESA_RS12580	COG2977	Belongs to the P-Pant transferase superfamily
ESA_RS12595	COG0840	transmembrane signaling receptor activity
ESA_RS12660	COG3772	lysozyme
ESA_RS12690	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ESA_RS12695	COG0582	viral genome integration into host DNA
ESA_RS12710	COG2501	S4 domain
ESA_RS12715	COG2190	(PTS) system
ESA_RS12715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS12715	COG1263	PTS System
ESA_RS12720	COG1609	Transcriptional regulator
ESA_RS12730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ESA_RS12740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ESA_RS12745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ESA_RS12750	COG0626	cystathionine gamma-synthase activity
ESA_RS12765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ESA_RS12770	COG4181	ATPase activity
ESA_RS12775	COG2755	lipolytic protein G-D-S-L family
ESA_RS12780	COG0300	oxidoreductase activity
ESA_RS12785	COG3118	belongs to the thioredoxin family
ESA_RS12790	COG0330	HflC and HflK could
ESA_RS12795	COG1585	Membrane protein implicated in regulation of membrane protease activity
ESA_RS12820	COG3735	TraB family
ESA_RS12830	COG0737	Belongs to the 5'-nucleotidase family
ESA_RS12835	COG4651	solute:proton antiporter activity
ESA_RS12835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ESA_RS12840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESA_RS12850	COG1929	Belongs to the glycerate kinase type-1 family
ESA_RS12855	COG2610	gluconate transmembrane transporter activity
ESA_RS12860	COG3835	regulator
ESA_RS12920	COG2832	Protein of unknown function (DUF454)
ESA_RS12925	COG3923	Primosomal replication protein n
ESA_RS12930	COG1196	nuclear chromosome segregation
ESA_RS12930	COG3264	Mechanosensitive ion channel
ESA_RS12935	COG1309	transcriptional regulator
ESA_RS12940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESA_RS12945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ESA_RS12960	COG0110	maltose O-acetyltransferase activity
ESA_RS12975	COG0840	transmembrane signaling receptor activity
ESA_RS12995	COG2011	ABC-type metal ion transport system permease component
ESA_RS13000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ESA_RS13005	COG0456	acetyltransferase
ESA_RS13005	COG1214	PFAM Peptidase M22, glycoprotease
ESA_RS13035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ESA_RS13040	COG1518	maintenance of DNA repeat elements
ESA_RS13055	COG1857	crispr-associated protein
ESA_RS13075	COG3695	enzyme binding
ESA_RS13080	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ESA_RS13085	COG1946	Acyl-CoA thioesterase
ESA_RS13090	COG0004	ammonium transporteR
ESA_RS13095	COG0347	Belongs to the P(II) protein family
ESA_RS13100	COG1132	(ABC) transporter
ESA_RS13105	COG1132	(ABC) transporter
ESA_RS13110	COG1522	sequence-specific DNA binding
ESA_RS13135	COG4533	DNA binding
ESA_RS13150	COG0824	Thioesterase
ESA_RS13155	COG1555	photosystem II stabilization
ESA_RS13160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ESA_RS13165	COG0776	regulation of translation
ESA_RS13170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ESA_RS13190	COG0271	Belongs to the BolA IbaG family
ESA_RS13195	COG3056	Lipoprotein
ESA_RS13200	COG2223	nitrite transmembrane transporter activity
ESA_RS13210	COG0443	Heat shock 70 kDa protein
ESA_RS13215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ESA_RS13220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ESA_RS13225	COG1845	cytochrome c oxidase, subunit III
ESA_RS13230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ESA_RS13240	COG2814	Major facilitator Superfamily
ESA_RS13250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ESA_RS13270	COG0142	geranyltranstransferase activity
ESA_RS13280	COG0667	Aldo Keto reductase
ESA_RS13285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ESA_RS13290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ESA_RS13305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESA_RS13305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESA_RS13315	COG4238	major outer membrane lipoprotein
ESA_RS13320	COG3248	Nucleoside-binding outer membrane protein
ESA_RS13325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESA_RS13330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESA_RS13335	COG1862	Preprotein translocase
ESA_RS13350	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ESA_RS13365	COG0366	Alpha amylase catalytic
ESA_RS13380	COG5002	protein histidine kinase activity
ESA_RS13390	COG0420	3'-5' exonuclease activity
ESA_RS13395	COG0419	ATPase involved in DNA repair
ESA_RS13400	COG1940	carbohydrate kinase activity
ESA_RS13415	COG4126	flavin adenine dinucleotide binding
ESA_RS13430	COG3416	Protein conserved in bacteria
ESA_RS13440	COG2323	membrane
ESA_RS13450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ESA_RS13455	COG2814	Major facilitator Superfamily
ESA_RS13465	COG2814	Major facilitator Superfamily
ESA_RS13475	COG1181	Belongs to the D-alanine--D-alanine ligase family
ESA_RS13495	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ESA_RS13505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ESA_RS13510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESA_RS13520	COG1546	Belongs to the CinA family
ESA_RS13525	COG0113	porphobilinogen synthase activity
ESA_RS13540	COG2175	clavaminate synthase activity
ESA_RS13545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESA_RS13555	COG4521	taurine ABC transporter
ESA_RS13560	COG2040	homocysteine
ESA_RS13565	COG0833	amino acid
ESA_RS13570	COG3383	formate dehydrogenase (NAD+) activity
ESA_RS13580	COG1271	oxidase subunit
ESA_RS13595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ESA_RS13600	COG1560	Kdo2-lipid A biosynthetic process
ESA_RS13605	COG1349	DNA-binding transcription factor activity
ESA_RS13610	COG0494	nUDIX hydrolase
ESA_RS13620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ESA_RS13630	COG0288	reversible hydration of carbon dioxide
ESA_RS13635	COG0659	secondary active sulfate transmembrane transporter activity
ESA_RS13640	COG0628	permease
ESA_RS13645	COG4993	Dehydrogenase
ESA_RS13650	COG0583	DNA-binding transcription factor activity
ESA_RS13670	COG3479	Phenolic acid decarboxylase
ESA_RS13680	COG1464	Belongs to the NlpA lipoprotein family
ESA_RS13685	COG2011	ABC-type metal ion transport system permease component
ESA_RS13710	COG2223	nitrite transmembrane transporter activity
ESA_RS13735	COG1309	transcriptional regulator
ESA_RS13740	COG0251	oxidation-reduction process
ESA_RS13745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ESA_RS13805	COG0747	negative chemotaxis
ESA_RS13810	COG2195	Cleaves the N-terminal amino acid of tripeptides
ESA_RS13905	COG0582	viral genome integration into host DNA
ESA_RS13910	COG2246	polysaccharide biosynthetic process
ESA_RS13915	COG0463	Glycosyl transferase, family 2
ESA_RS14035	COG5410	chromosome segregation
ESA_RS14040	COG3728	DNA packaging
ESA_RS14040	COG5484	DNA packaging
ESA_RS14085	COG3772	lysozyme
ESA_RS14170	COG0305	Participates in initiation and elongation during chromosome replication
ESA_RS14280	COG0582	viral genome integration into host DNA
ESA_RS14300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ESA_RS14320	COG2195	Cleaves the N-terminal amino acid of tripeptides
ESA_RS14330	COG3034	peptidoglycan biosynthetic process
ESA_RS14335	COG0121	glutamine amidotransferase
ESA_RS14350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ESA_RS14370	COG2226	methyltransferase
ESA_RS14380	COG0741	lytic transglycosylase activity
ESA_RS14380	COG1388	LysM domain
ESA_RS14385	COG2226	methyltransferase
ESA_RS14390	COG3021	interspecies interaction between organisms
ESA_RS14395	COG0583	DNA-binding transcription factor activity
ESA_RS14430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ESA_RS14440	COG2011	ABC-type metal ion transport system permease component
ESA_RS14455	COG1720	tRNA m6t6A37 methyltransferase activity
ESA_RS14465	COG3015	lipoprotein NlpE involved in copper resistance
ESA_RS14470	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ESA_RS14475	COG4681	YaeQ
ESA_RS14485	COG4568	rho-dependent transcription termination
ESA_RS14500	COG0346	lactoylglutathione lyase activity
ESA_RS14505	COG1982	Orn Lys Arg decarboxylase major
ESA_RS14545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ESA_RS14560	COG0750	zinc metalloprotease
ESA_RS14565	COG0575	Belongs to the CDS family
ESA_RS14575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ESA_RS14620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESA_RS14640	COG2860	membrane
ESA_RS14660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESA_RS14665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ESA_RS14670	COG1120	ATPase activity
ESA_RS14675	COG4774	siderophore transport
ESA_RS14680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESA_RS14685	COG1643	Atp-dependent helicase
ESA_RS14690	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ESA_RS14700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ESA_RS14710	COG0617	tRNA 3'-terminal CCA addition
ESA_RS14715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ESA_RS14735	COG0726	polysaccharide deacetylase
ESA_RS14740	COG0842	Transport permease protein
ESA_RS14745	COG1131	(ABC) transporter
ESA_RS14750	COG0288	reversible hydration of carbon dioxide
ESA_RS14760	COG4993	Dehydrogenase
ESA_RS14765	COG2132	Multicopper oxidase
ESA_RS14795	COG1049	propionate catabolic process, 2-methylcitrate cycle
ESA_RS14800	COG3064	Membrane
ESA_RS14815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESA_RS14820	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESA_RS14825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ESA_RS14830	COG2186	Transcriptional regulator
ESA_RS14835	COG1113	amino acid transport
ESA_RS14840	COG2211	Major facilitator Superfamily
ESA_RS14845	COG3940	Belongs to the glycosyl hydrolase 43 family
ESA_RS14850	COG3725	Membrane protein required for beta-lactamase induction
ESA_RS14865	COG4969	Belongs to the N-Me-Phe pilin family
ESA_RS14870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ESA_RS14875	COG1459	type II secretion system
ESA_RS14880	COG0516	GMP reductase activity
ESA_RS14900	COG0494	nUDIX hydrolase
ESA_RS14920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ESA_RS14925	COG0849	cell division
ESA_RS14935	COG1181	Belongs to the D-alanine--D-alanine ligase family
ESA_RS14950	COG0772	Belongs to the SEDS family
ESA_RS14965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ESA_RS14975	COG0768	penicillin binding
ESA_RS14995	COG1609	Transcriptional regulator
ESA_RS15005	COG0028	Belongs to the TPP enzyme family
ESA_RS15035	COG2814	Major facilitator Superfamily
ESA_RS15050	COG1178	ABC-type Fe3 transport system permease component
ESA_RS15055	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ESA_RS15060	COG0586	Pfam SNARE associated Golgi protein
ESA_RS15065	COG4977	sequence-specific DNA binding
ESA_RS15075	COG2160	L-arabinose isomerase activity
ESA_RS15080	COG0235	Class ii aldolase
ESA_RS15085	COG0417	DNA replication proofreading
ESA_RS15095	COG0564	pseudouridine synthase activity
ESA_RS15105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ESA_RS15110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ESA_RS15140	COG1280	lysine exporter protein (LysE YggA)
ESA_RS15170	COG0505	Belongs to the CarA family
ESA_RS15180	COG1737	Transcriptional regulator
ESA_RS15190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESA_RS15195	COG0383	alpha-mannosidase activity
ESA_RS15205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ESA_RS15225	COG1047	Peptidyl-prolyl cis-trans
ESA_RS15240	COG0196	riboflavin kinase activity
ESA_RS15250	COG0583	DNA-binding transcription factor activity
ESA_RS15300	COG1584	GPR1 FUN34 yaaH family protein
ESA_RS15310	COG0521	Mo-molybdopterin cofactor biosynthetic process
ESA_RS15320	COG1115	amino acid carrier protein
ESA_RS15330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ESA_RS15340	COG0527	aspartate kinase activity
ESA_RS15340	COG0460	homoserine dehydrogenase
ESA_RS15345	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ESA_RS15350	COG0745	RESPONSE REGULATOR receiver
ESA_RS15355	COG4452	Inner membrane protein CreD
ESA_RS15360	COG2205	protein histidine kinase activity
ESA_RS15365	COG0745	RESPONSE REGULATOR receiver
ESA_RS15370	COG3045	CreA protein
ESA_RS15375	COG2207	Transcriptional regulator
ESA_RS15375	COG3708	Transcriptional regulator
ESA_RS15395	COG0741	lytic transglycosylase activity
ESA_RS15400	COG0488	(ABC) transporter
ESA_RS15465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ESA_RS15470	COG0560	Phosphoserine phosphatase
ESA_RS15475	COG3726	membrane protein affecting hemolysin expression
ESA_RS15505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ESA_RS15510	COG0084	hydrolase, TatD family'
ESA_RS15515	COG4667	esterase of the alpha-beta hydrolase superfamily
ESA_RS15520	COG2823	Periplasmic or secreted lipoprotein
ESA_RS15530	COG1011	Hydrolase
ESA_RS15535	COG0456	acetyltransferase
ESA_RS15540	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ESA_RS15570	COG3706	GGDEF domain
ESA_RS15575	COG4114	ferric iron reductase
ESA_RS15580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESA_RS15585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESA_RS15590	COG2197	response regulator
ESA_RS15595	COG2197	response regulator
ESA_RS15600	COG2966	Psort location CytoplasmicMembrane, score
ESA_RS15610	COG1846	Transcriptional regulator
ESA_RS15615	COG1764	response to oxidative stress
ESA_RS15625	COG1484	DNA-dependent DNA replication
ESA_RS15645	COG0840	transmembrane signaling receptor activity
ESA_RS15660	COG0402	S-adenosylhomocysteine deaminase activity
ESA_RS15665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESA_RS15670	COG2723	6-phospho-beta-galactosidase activity
ESA_RS15675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESA_RS15675	COG1263	PTS System
ESA_RS15680	COG1609	Transcriptional regulator
ESA_RS15695	COG1566	PFAM secretion protein HlyD family protein
ESA_RS15705	COG1609	Transcriptional regulator
ESA_RS15720	COG1874	Beta-galactosidase
ESA_RS15725	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ESA_RS15730	COG3833	ABC-type maltose transport systems, permease component
ESA_RS15735	COG1175	transmembrane transport
ESA_RS15740	COG2182	Extracellular solute-binding protein
ESA_RS15755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESA_RS15760	COG2733	membrane
ESA_RS15770	COG3157	Type VI secretion system effector, Hcp
ESA_RS15815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ESA_RS15820	COG1064	alcohol dehydrogenase
ESA_RS15840	COG0795	lipopolysaccharide-transporting ATPase activity
ESA_RS15845	COG0795	lipopolysaccharide-transporting ATPase activity
ESA_RS15855	COG2927	DNA polymerase III (CHI subunit)
ESA_RS15865	COG4269	membrane
ESA_RS15895	COG2731	YhcH YjgK YiaL family protein
ESA_RS15905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ESA_RS15910	COG1064	alcohol dehydrogenase
ESA_RS15935	COG0795	lipopolysaccharide-transporting ATPase activity
ESA_RS15945	COG2927	DNA polymerase III (CHI subunit)
ESA_RS15955	COG4269	membrane
ESA_RS15985	COG2731	YhcH YjgK YiaL family protein
ESA_RS15990	COG2235	arginine
ESA_RS15995	COG0549	Belongs to the carbamate kinase family
ESA_RS16000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ESA_RS16005	COG1288	antiporter activity
ESA_RS16010	COG1438	arginine binding
ESA_RS16025	COG0251	oxidation-reduction process
ESA_RS16030	COG1032	radical SAM domain protein
ESA_RS16035	COG2375	cellular response to nickel ion
ESA_RS16040	COG1695	Transcriptional regulator
ESA_RS16045	COG0840	transmembrane signaling receptor activity
ESA_RS16050	COG0840	transmembrane signaling receptor activity
ESA_RS16055	COG3706	GGDEF domain
ESA_RS16065	COG1902	pentaerythritol trinitrate reductase activity
ESA_RS16065	COG0446	pyridine nucleotide-disulphide oxidoreductase
ESA_RS16075	COG1451	nucleotide metabolic process
ESA_RS16080	COG2949	membrane
ESA_RS16085	COG0673	inositol 2-dehydrogenase activity
ESA_RS16105	COG2721	sulfolactate sulfo-lyase activity
ESA_RS16115	COG2271	Major facilitator Superfamily
ESA_RS16120	COG2186	Transcriptional regulator
ESA_RS16125	COG0586	Pfam SNARE associated Golgi protein
ESA_RS16135	COG1422	Protein of unknown function (DUF1090)
ESA_RS16140	COG4575	ribosome binding
ESA_RS16145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ESA_RS16170	COG3188	usher protein
ESA_RS16175	COG3121	Chaperone
ESA_RS16180	COG3539	Fimbrial protein
ESA_RS16200	COG3539	Fimbrial protein
ESA_RS16205	COG2259	Doxx family
ESA_RS16210	COG0435	Glutathione S-transferase
ESA_RS16215	COG3152	Membrane
ESA_RS16245	COG0583	DNA-binding transcription factor activity
ESA_RS16250	COG1741	Belongs to the pirin family
ESA_RS16255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ESA_RS16260	COG3107	peptidoglycan biosynthetic process
ESA_RS16275	COG2823	Periplasmic or secreted lipoprotein
ESA_RS16280	COG0701	Predicted permease
ESA_RS16285	COG0702	epimerase
ESA_RS16290	COG0693	protein deglycase activity
ESA_RS16305	COG3153	acetyltransferase
ESA_RS16310	COG3154	lipid carrier protein
ESA_RS16315	COG0826	peptidase U32
ESA_RS16320	COG0826	peptidase U32
ESA_RS16325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESA_RS16330	COG0814	amino acid
ESA_RS16335	COG0513	Belongs to the DEAD box helicase family
ESA_RS16370	COG0195	Participates in both transcription termination and antitermination
ESA_RS16390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ESA_RS16400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ESA_RS16405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESA_RS16415	COG1534	Rna-binding protein
ESA_RS16420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ESA_RS16425	COG2027	D-alanyl-D-alanine carboxypeptidase
ESA_RS16430	COG0745	RESPONSE REGULATOR receiver
ESA_RS16435	COG0642	Histidine kinase
ESA_RS16445	COG0697	spore germination
ESA_RS16460	COG0142	geranyltranstransferase activity
ESA_RS16465	COG3423	Transcriptional regulator
ESA_RS16475	COG5007	Belongs to the BolA IbaG family
ESA_RS16480	COG3113	response to antibiotic
ESA_RS16485	COG2854	intermembrane phospholipid transfer
ESA_RS16490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ESA_RS16495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ESA_RS16500	COG1127	ABC transporter
ESA_RS16505	COG0530	calcium, potassium:sodium antiporter activity
ESA_RS16515	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ESA_RS16520	COG3117	lipopolysaccharide transmembrane transporter activity
ESA_RS16525	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ESA_RS16530	COG1137	ATPase activity
ESA_RS16535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ESA_RS16555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS16565	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ESA_RS16570	COG2198	Histidine kinase
ESA_RS16570	COG0784	Response regulator, receiver
ESA_RS16570	COG5002	protein histidine kinase activity
ESA_RS16575	COG1242	4 iron, 4 sulfur cluster binding
ESA_RS16580	COG0069	glutamate synthase activity
ESA_RS16580	COG0070	glutamate synthase
ESA_RS16580	COG0067	glutamate synthase
ESA_RS16585	COG0493	'glutamate synthase
ESA_RS16595	COG2731	YhcH YjgK YiaL family protein
ESA_RS16620	COG2969	positive regulation of protein catabolic process
ESA_RS16625	COG0625	glutathione transferase activity
ESA_RS16640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ESA_RS16645	COG3105	Protein conserved in bacteria
ESA_RS16650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESA_RS16655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESA_RS16680	COG2732	(Barnase) inhibitor
ESA_RS16690	COG1289	transmembrane transporter activity
ESA_RS16705	COG0583	DNA-binding transcription factor activity
ESA_RS16710	COG0312	modulator of DNA gyrase
ESA_RS16715	COG3164	Protein of unknown function
ESA_RS16730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ESA_RS16735	COG1792	Involved in formation and maintenance of cell shape
ESA_RS16740	COG1077	Cell shape determining protein MreB Mrl
ESA_RS16745	COG2199	diguanylate cyclase activity
ESA_RS16745	COG2200	EAL domain
ESA_RS16750	COG0604	alcohol dehydrogenase
ESA_RS16765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ESA_RS16770	COG0511	ligase activity, forming carbon-carbon bonds
ESA_RS16775	COG0439	Biotin carboxylase
ESA_RS16780	COG3924	membrane
ESA_RS16785	COG4145	pantothenate transmembrane transporter activity
ESA_RS16815	COG1309	transcriptional regulator
ESA_RS16820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESA_RS16835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESA_RS16840	COG4597	amino acid ABC transporter
ESA_RS16845	COG0765	amino acid transport
ESA_RS16850	COG1126	abc transporter atp-binding protein
ESA_RS16890	COG0151	Belongs to the GarS family
ESA_RS16925	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ESA_RS16940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ESA_RS16945	COG2104	thiamine diphosphate biosynthetic process
ESA_RS16955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ESA_RS16965	COG1447	Phosphotransferase system cellobiose-specific component IIA
ESA_RS16970	COG3708	Transcriptional regulator
ESA_RS16970	COG2207	Transcriptional regulator
ESA_RS17010	COG0250	Participates in transcription elongation, termination and antitermination
ESA_RS17055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ESA_RS17090	COG1739	Uncharacterized protein family UPF0029
ESA_RS17140	COG0805	protein transport
ESA_RS17145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESA_RS17150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESA_RS17190	COG0583	DNA-binding transcription factor activity
ESA_RS17200	COG0561	phosphatase activity
ESA_RS17205	COG2267	carboxylic ester hydrolase activity
ESA_RS17210	COG1280	lysine exporter protein (LysE YggA)
ESA_RS17215	COG1280	lysine exporter protein (LysE YggA)
ESA_RS17225	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ESA_RS17230	COG2050	protein possibly involved in aromatic compounds catabolism
ESA_RS17255	COG0210	DNA helicase
ESA_RS17260	COG1011	Hydrolase
ESA_RS17270	COG3159	Protein conserved in bacteria
ESA_RS17280	COG5567	small periplasmic lipoprotein
ESA_RS17305	COG2959	enzyme of heme biosynthesis
ESA_RS17310	COG3071	HemY protein
ESA_RS17360	COG2244	polysaccharide biosynthetic process
ESA_RS17365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ESA_RS17370	COG0456	acetyltransferase
ESA_RS17375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ESA_RS17380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ESA_RS17390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESA_RS17395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ESA_RS17400	COG3118	belongs to the thioredoxin family
ESA_RS17415	COG0210	DNA helicase
ESA_RS17430	COG0583	DNA-binding transcription factor activity
ESA_RS17450	COG3978	acetolactate synthase activity
ESA_RS17460	COG0606	chelatase, subunit chli
ESA_RS17465	COG3085	chromosome segregation
ESA_RS17540	COG0583	DNA-binding transcription factor activity
ESA_RS17560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ESA_RS17585	COG3121	Chaperone
ESA_RS17605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ESA_RS17610	COG0460	homoserine dehydrogenase
ESA_RS17610	COG0527	aspartate kinase activity
ESA_RS17615	COG0626	cystathionine gamma-synthase activity
ESA_RS17630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ESA_RS17635	COG1609	Transcriptional regulator
ESA_RS17640	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ESA_RS17645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ESA_RS17655	COG1575	Belongs to the MenA family. Type 1 subfamily
ESA_RS17670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ESA_RS17700	COG2186	Transcriptional regulator
ESA_RS17710	COG2258	MOSC domain
ESA_RS17715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ESA_RS17730	COG4977	sequence-specific DNA binding
ESA_RS17750	COG1454	alcohol dehydrogenase
ESA_RS17760	COG2211	Major facilitator Superfamily
ESA_RS17780	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ESA_RS17800	COG0243	molybdopterin cofactor binding
ESA_RS17800	COG3383	formate dehydrogenase (NAD+) activity
ESA_RS17805	COG3383	formate dehydrogenase (NAD+) activity
ESA_RS17805	COG0243	molybdopterin cofactor binding
ESA_RS17810	COG0437	4 iron, 4 sulfur cluster binding
ESA_RS17815	COG2864	formate dehydrogenase
ESA_RS17830	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ESA_RS17840	COG2211	Major facilitator Superfamily
ESA_RS17855	COG1940	carbohydrate kinase activity
ESA_RS17860	COG1454	alcohol dehydrogenase
ESA_RS17865	COG3276	selenocysteine insertion sequence binding
ESA_RS17875	COG0625	glutathione transferase activity
ESA_RS17880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESA_RS17880	COG2213	PTS system mannitol-specific
ESA_RS17890	COG3722	fumarate hydratase activity
ESA_RS17895	COG1494	fructose-1,6-bisphosphatase
ESA_RS17905	COG3152	Membrane
ESA_RS17915	COG0149	triose-phosphate isomerase activity
ESA_RS18060	COG0515	serine threonine protein kinase
ESA_RS18200	COG2814	Major facilitator Superfamily
ESA_RS18215	COG2149	membrane
ESA_RS18230	COG2188	Transcriptional regulator
ESA_RS18245	COG5645	(Lipo)protein
ESA_RS18250	COG0823	Involved in the tonB-independent uptake of proteins
ESA_RS18255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ESA_RS18265	COG2271	Major facilitator Superfamily
ESA_RS18275	COG0800	Aldolase
ESA_RS18280	COG3734	2-keto-3-deoxy-galactonokinase
ESA_RS18285	COG2186	Transcriptional regulator
ESA_RS18295	COG0561	phosphatase activity
ESA_RS18300	COG0187	DNA topoisomerase II activity
ESA_RS18310	COG0592	DNA-directed DNA polymerase activity
ESA_RS18355	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ESA_RS18375	COG2091	lysine biosynthetic process via aminoadipic acid
ESA_RS18380	COG0431	NADPH-dependent FMN reductase
ESA_RS18385	COG2252	PERMEase
ESA_RS18390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESA_RS18395	COG2382	esterase
ESA_RS18400	COG0704	Plays a role in the regulation of phosphate uptake
ESA_RS18405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ESA_RS18410	COG0581	inorganic phosphate transmembrane transporter activity
ESA_RS18415	COG0573	inorganic phosphate transmembrane transporter activity
ESA_RS18420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ESA_RS18485	COG3312	ion transport
ESA_RS18500	COG0716	FMN binding
ESA_RS18505	COG1522	sequence-specific DNA binding
ESA_RS18535	COG1129	ABC transporter
ESA_RS18540	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESA_RS18550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESA_RS18555	COG1609	Transcriptional regulator
ESA_RS18560	COG0477	Major facilitator Superfamily
ESA_RS18565	COG2186	Transcriptional regulator
ESA_RS18590	COG1763	Mo-molybdopterin cofactor biosynthetic process
ESA_RS18595	COG0746	molybdenum cofactor guanylyltransferase activity
ESA_RS18600	COG3084	Protein conserved in bacteria
ESA_RS18605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ESA_RS18615	COG0204	Acyl-transferase
ESA_RS18635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ESA_RS18645	COG3852	Histidine kinase
ESA_RS18660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ESA_RS18680	COG1501	Belongs to the glycosyl hydrolase 31 family
ESA_RS18685	COG2017	converts alpha-aldose to the beta-anomer
ESA_RS18700	COG2084	Dehydrogenase
ESA_RS18705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESA_RS18710	COG1349	DNA-binding transcription factor activity
ESA_RS18715	COG1011	Hydrolase
ESA_RS18730	COG0456	acetyltransferase
ESA_RS18735	COG2982	Protein involved in outer membrane biogenesis
ESA_RS18740	COG2233	PERMEase
ESA_RS18765	COG3188	usher protein
ESA_RS18770	COG3121	Chaperone
ESA_RS18780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ESA_RS18785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESA_RS18790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ESA_RS18800	COG0194	GDP metabolic process
ESA_RS18810	COG2860	membrane
ESA_RS18825	COG1396	sequence-specific DNA binding
ESA_RS18845	COG0582	viral genome integration into host DNA
ESA_RS18850	COG1561	YicC-like family, N-terminal region
ESA_RS18875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESA_RS18885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ESA_RS18890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESA_RS18910	COG1519	Transferase
ESA_RS18925	COG1216	Glycosyl transferase, family 2
ESA_RS18935	COG0438	transferase activity, transferring glycosyl groups
ESA_RS18940	COG0438	transferase activity, transferring glycosyl groups
ESA_RS18945	COG0859	PFAM glycosyl transferase family 9
ESA_RS18950	COG0859	PFAM glycosyl transferase family 9
ESA_RS18955	COG0859	PFAM glycosyl transferase family 9
ESA_RS18965	COG0156	8-amino-7-oxononanoate synthase activity
ESA_RS18975	COG0463	Glycosyl transferase, family 2
ESA_RS18980	COG2861	carbohydrate metabolic process
ESA_RS18985	COG4942	peptidase
ESA_RS18995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ESA_RS19000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ESA_RS19020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ESA_RS19025	COG2205	protein histidine kinase activity
ESA_RS19030	COG0745	RESPONSE REGULATOR receiver
ESA_RS19035	COG3678	ATP-independent chaperone mediated protein folding
ESA_RS19070	COG2351	hydroxyisourate hydrolase activity
ESA_RS19075	COG0745	RESPONSE REGULATOR receiver
ESA_RS19080	COG2205	protein histidine kinase activity
ESA_RS19100	COG1064	alcohol dehydrogenase
ESA_RS19120	COG2080	2 iron, 2 sulfur cluster binding
ESA_RS19125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ESA_RS19130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ESA_RS19135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ESA_RS19140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ESA_RS19145	COG0667	Aldo Keto reductase
ESA_RS19170	COG2211	Major facilitator Superfamily
ESA_RS19175	COG1501	Belongs to the glycosyl hydrolase 31 family
ESA_RS19180	COG3977	Valine--pyruvate aminotransferase
ESA_RS19185	COG0366	Alpha amylase catalytic
ESA_RS19190	COG2992	FlgJ-related protein
ESA_RS19195	COG1609	Transcriptional regulator
ESA_RS19195	COG2207	Transcriptional regulator
ESA_RS19200	COG4214	carbohydrate transport
ESA_RS19210	COG4213	ABC transporter substrate-binding protein
ESA_RS19220	COG1070	Carbohydrate kinase
ESA_RS19225	COG1335	isochorismatase
ESA_RS19235	COG3274	enterobacterial common antigen metabolic process
ESA_RS19255	COG2944	sequence-specific DNA binding
ESA_RS19285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESA_RS19295	COG1609	Transcriptional regulator
ESA_RS19300	COG3443	Belongs to the bacterial solute-binding protein 9 family
ESA_RS19305	COG2885	chlorophyll binding
ESA_RS19310	COG0243	molybdopterin cofactor binding
ESA_RS19320	COG2818	Glycosylase
ESA_RS19325	COG5571	outer membrane autotransporter
ESA_RS19330	COG2223	nitrite transmembrane transporter activity
ESA_RS19335	COG1764	response to oxidative stress
ESA_RS19360	COG0747	negative chemotaxis
ESA_RS19365	COG0601	transmembrane transport
ESA_RS19370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESA_RS19375	COG0444	Belongs to the ABC transporter superfamily
ESA_RS19380	COG4608	Belongs to the ABC transporter superfamily
ESA_RS19385	COG2194	sulfuric ester hydrolase activity
ESA_RS19410	COG1215	transferase activity, transferring glycosyl groups
ESA_RS19415	COG1215	transferase activity, transferring glycosyl groups
ESA_RS19425	COG3118	belongs to the thioredoxin family
ESA_RS19425	COG0457	Tetratricopeptide repeat
ESA_RS19430	COG2199	diguanylate cyclase activity
ESA_RS19430	COG2200	EAL domain
ESA_RS19440	COG0612	Peptidase, M16
ESA_RS19450	COG2200	EAL domain
ESA_RS19455	COG2982	Protein involved in outer membrane biogenesis
ESA_RS19460	COG0477	Major facilitator Superfamily
ESA_RS19465	COG1295	ribonuclease BN
ESA_RS19470	COG0583	DNA-binding transcription factor activity
ESA_RS19475	COG1028	Short-chain dehydrogenase reductase Sdr
ESA_RS19480	COG3111	PFAM Bacterial OB fold (BOF) protein
ESA_RS19500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESA_RS19505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ESA_RS19530	COG0306	phosphate transporter
ESA_RS19535	COG2081	HI0933 family
ESA_RS19580	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESA_RS19610	COG0739	heme binding
ESA_RS19620	COG2132	Multicopper oxidase
ESA_RS19625	COG3667	copper resistance
ESA_RS19630	COG2372	response to copper ion
ESA_RS19635	COG1276	copper resistance
ESA_RS19640	COG0745	RESPONSE REGULATOR receiver
ESA_RS19645	COG2205	protein histidine kinase activity
ESA_RS19655	COG0174	glutamine synthetase
ESA_RS19660	COG0791	NLP P60 protein
ESA_RS19665	COG0628	permease
ESA_RS19680	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ESA_RS19690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ESA_RS19710	COG3714	YhhN family
ESA_RS19720	COG3776	membrane
ESA_RS19725	COG0742	ribosomal rna small subunit methyltransferase
ESA_RS19730	COG0552	protein localization to endoplasmic reticulum
ESA_RS19735	COG2884	Cell division ATP-binding protein ftsE
ESA_RS19740	COG2177	Part of the ABC transporter FtsEX involved in
ESA_RS19745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ESA_RS19755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ESA_RS19765	COG0683	leucine binding
ESA_RS19775	COG0683	leucine binding
ESA_RS19785	COG4177	L-phenylalanine transmembrane transporter activity
ESA_RS19795	COG0410	ABC transporter
ESA_RS19830	COG0584	glycerophosphoryl diester phosphodiesterase
ESA_RS19840	COG0405	Gamma-glutamyltransferase
ESA_RS19845	COG1247	-acetyltransferase
ESA_RS19850	COG0673	inositol 2-dehydrogenase activity
ESA_RS19855	COG1741	Belongs to the pirin family
ESA_RS19860	COG1609	Transcriptional regulator
ESA_RS19865	COG3265	gluconokinase activity
ESA_RS19870	COG2610	gluconate transmembrane transporter activity
ESA_RS19885	COG2095	MarC family integral membrane protein
ESA_RS19915	COG0058	SHG alpha-glucan phosphorylase activity
ESA_RS19925	COG5001	Diguanylate cyclase
ESA_RS19925	COG4251	negative regulation of phosphorylation
ESA_RS19925	COG3706	GGDEF domain
ESA_RS19925	COG2203	Gaf domain
ESA_RS19930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ESA_RS19935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ESA_RS19945	COG1349	DNA-binding transcription factor activity
ESA_RS19955	COG0058	SHG alpha-glucan phosphorylase activity
ESA_RS19960	COG1640	4-alpha-glucanotransferase
ESA_RS19965	COG1278	Cold shock
ESA_RS19975	COG1040	competence protein
ESA_RS20000	COG1918	ferrous iron import across plasma membrane
ESA_RS20005	COG2183	response to ionizing radiation
ESA_RS20010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ESA_RS20030	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ESA_RS20040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ESA_RS20045	COG1011	Hydrolase
ESA_RS20055	COG0494	nUDIX hydrolase
ESA_RS20060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ESA_RS20065	COG4972	Pilus assembly protein
ESA_RS20085	COG4796	Type ii and iii secretion system protein
ESA_RS20100	COG3266	domain, Protein
ESA_RS20105	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ESA_RS20110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ESA_RS20120	COG0180	Tryptophanyl-tRNA synthetase
ESA_RS20130	COG2188	Transcriptional regulator
ESA_RS20140	COG1082	Xylose isomerase domain protein TIM barrel
ESA_RS20145	COG2222	sugar isomerase
ESA_RS20150	COG0531	amino acid
ESA_RS20160	COG2146	nitrite reductase [NAD(P)H] activity
ESA_RS20165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ESA_RS20195	COG1289	transmembrane transporter activity
ESA_RS20205	COG1765	OsmC-like protein
ESA_RS20210	COG3954	Phosphoribulokinase
ESA_RS20220	COG0429	hydrolase of the alpha beta-hydrolase fold
ESA_RS20230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ESA_RS20245	COG3853	Toxic anion resistance protein (TelA)
ESA_RS20250	COG0488	(ABC) transporter
ESA_RS20265	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ESA_RS20270	COG1047	Peptidyl-prolyl cis-trans
ESA_RS20280	COG0545	Peptidyl-prolyl cis-trans isomerase
ESA_RS20285	COG2964	Protein conserved in bacteria
ESA_RS20575	COG0758	DNA mediated transformation
ESA_RS20825	COG2224	Isocitrate lyase
ESA_RS21080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate