locus-tag	class	description
CSP5_RS00005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CSP5_RS00005	COG0551	DNA topoisomerase type I activity
CSP5_RS00015	COG4946	Tricorn protease homolog
CSP5_RS00015	COG0793	Belongs to the peptidase S41A family
CSP5_RS00025	COG0138	bifunctional purine biosynthesis protein purh
CSP5_RS00030	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
CSP5_RS00060	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CSP5_RS00090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CSP5_RS00120	COG0504	CTP synthase activity
CSP5_RS00160	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
CSP5_RS00210	COG1269	ATP hydrolysis coupled proton transport
CSP5_RS00220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CSP5_RS00230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSP5_RS00240	COG1304	FMN binding
CSP5_RS00285	COG1192	Involved in chromosome partitioning
CSP5_RS00310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CSP5_RS00330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSP5_RS00385	COG2217	Heavy metal translocating P-type atpase
CSP5_RS00430	COG1131	(ABC) transporter
CSP5_RS00520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSP5_RS00535	COG1061	Type III restriction enzyme res subunit
CSP5_RS00555	COG0640	Transcriptional regulator
CSP5_RS00560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CSP5_RS00590	COG0318	PFAM AMP-dependent synthetase and ligase
CSP5_RS00600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CSP5_RS00615	COG0006	proline dipeptidase activity
CSP5_RS00640	COG0656	L-ascorbic acid biosynthetic process
CSP5_RS00670	COG1121	(ABC) transporter
CSP5_RS00675	COG3590	peptidase
CSP5_RS00695	COG0667	Aldo Keto reductase
CSP5_RS00700	COG2723	6-phospho-beta-galactosidase activity
CSP5_RS00715	COG4608	Belongs to the ABC transporter superfamily
CSP5_RS00720	COG0444	Belongs to the ABC transporter superfamily
CSP5_RS00725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSP5_RS00730	COG0601	transmembrane transport
CSP5_RS00760	COG2271	Major facilitator Superfamily
CSP5_RS00855	COG1446	asparaginase
CSP5_RS00870	COG0012	GTP binding
CSP5_RS00890	COG2086	electron transfer activity
CSP5_RS00910	COG0024	Methionine aminopeptidase
CSP5_RS00915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CSP5_RS00920	COG0626	cystathionine gamma-synthase activity
CSP5_RS00925	COG0531	amino acid
CSP5_RS00940	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSP5_RS00960	COG0372	Belongs to the citrate synthase family
CSP5_RS00965	COG1335	isochorismatase
CSP5_RS00985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CSP5_RS00995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CSP5_RS00995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CSP5_RS01010	COG0531	amino acid
CSP5_RS01040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CSP5_RS01075	COG2045	Belongs to the ComB family
CSP5_RS01080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CSP5_RS01085	COG0081	regulation of translation
CSP5_RS01110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CSP5_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CSP5_RS01130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CSP5_RS01135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CSP5_RS01145	COG0538	isocitrate dehydrogenase activity
CSP5_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
CSP5_RS01165	COG0321	lipoyl(octanoyl) transferase activity
CSP5_RS01180	COG0022	dehydrogenase e1 component
CSP5_RS01185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CSP5_RS01190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CSP5_RS01205	COG1505	serine-type exopeptidase activity
CSP5_RS01235	COG1064	alcohol dehydrogenase
CSP5_RS01240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CSP5_RS01300	COG1832	CoA-binding protein
CSP5_RS01325	COG0674	pyruvate-flavodoxin oxidoreductase activity
CSP5_RS01325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CSP5_RS01330	COG1013	pyruvate-flavodoxin oxidoreductase activity
CSP5_RS01350	COG0049	tRNA binding
CSP5_RS01375	COG4152	abc transporter atp-binding protein
CSP5_RS01380	COG2814	Major facilitator Superfamily
CSP5_RS01435	COG0415	Belongs to the DNA photolyase family
CSP5_RS01445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CSP5_RS01450	COG4946	Tricorn protease homolog
CSP5_RS01450	COG0793	Belongs to the peptidase S41A family
CSP5_RS01465	COG0142	geranyltranstransferase activity
CSP5_RS01470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CSP5_RS01495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CSP5_RS01500	COG0156	8-amino-7-oxononanoate synthase activity
CSP5_RS01515	COG0501	Belongs to the peptidase M48B family
CSP5_RS01525	COG0505	Belongs to the CarA family
CSP5_RS01530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CSP5_RS01540	COG1489	DNA binding
CSP5_RS01545	COG0516	GMP reductase activity
CSP5_RS01545	COG0517	IMP dehydrogenase activity
CSP5_RS01555	COG0463	Glycosyl transferase, family 2
CSP5_RS01595	COG0601	transmembrane transport
CSP5_RS01635	COG0163	prenyltransferase activity
CSP5_RS01680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CSP5_RS01690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CSP5_RS01710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CSP5_RS01715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CSP5_RS01755	COG0330	HflC and HflK could
CSP5_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
CSP5_RS01775	COG0028	Belongs to the TPP enzyme family
CSP5_RS01780	COG0697	spore germination
CSP5_RS01820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CSP5_RS01855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CSP5_RS01885	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CSP5_RS01890	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CSP5_RS01895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CSP5_RS01925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CSP5_RS01955	COG0527	aspartate kinase activity
CSP5_RS02005	COG2095	MarC family integral membrane protein
CSP5_RS02025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CSP5_RS02040	COG0793	Belongs to the peptidase S41A family
CSP5_RS02040	COG3409	Peptidoglycan-binding domain 1 protein
CSP5_RS02045	COG0113	porphobilinogen synthase activity
CSP5_RS02055	COG0039	L-malate dehydrogenase activity
CSP5_RS02060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CSP5_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
CSP5_RS02090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CSP5_RS02095	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CSP5_RS02110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CSP5_RS02115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CSP5_RS02145	COG1131	(ABC) transporter
CSP5_RS02170	COG0506	proline dehydrogenase activity
CSP5_RS02180	COG0552	protein localization to endoplasmic reticulum
CSP5_RS02190	COG0126	phosphoglycerate kinase activity
CSP5_RS02205	COG0110	maltose O-acetyltransferase activity
CSP5_RS02225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CSP5_RS02230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CSP5_RS02240	COG0459	protein refolding
CSP5_RS02250	COG1960	acyl-CoA dehydrogenase activity
CSP5_RS02260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CSP5_RS02275	COG0730	response to heat
CSP5_RS02315	COG1793	dna ligase
CSP5_RS02360	COG0028	Belongs to the TPP enzyme family
CSP5_RS02370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CSP5_RS02375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CSP5_RS02390	COG0009	L-threonylcarbamoyladenylate synthase
CSP5_RS02410	COG0517	IMP dehydrogenase activity
CSP5_RS02410	COG0516	GMP reductase activity
CSP5_RS02415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CSP5_RS02420	COG0477	Major facilitator Superfamily
CSP5_RS02430	COG0417	DNA replication proofreading
CSP5_RS02435	COG0644	oxidoreductase
CSP5_RS02450	COG3189	MarR family transcriptional regulator
CSP5_RS02455	COG0343	queuine tRNA-ribosyltransferase activity
CSP5_RS02460	COG1129	ABC transporter
CSP5_RS02470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CSP5_RS02500	COG0519	Catalyzes the synthesis of GMP from XMP
CSP5_RS02500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CSP5_RS02520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CSP5_RS02530	COG2151	metal-sulfur cluster biosynthetic enzyme
CSP5_RS02545	COG0585	pseudouridine synthase activity
CSP5_RS02550	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CSP5_RS02555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CSP5_RS02565	COG0517	IMP dehydrogenase activity
CSP5_RS02565	COG0516	GMP reductase activity
CSP5_RS02580	COG1131	(ABC) transporter
CSP5_RS02600	COG0584	glycerophosphoryl diester phosphodiesterase
CSP5_RS02605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CSP5_RS02605	COG0574	Belongs to the PEP-utilizing enzyme family
CSP5_RS02620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CSP5_RS02645	COG1252	NADH dehydrogenase
CSP5_RS02655	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CSP5_RS02690	COG0383	alpha-mannosidase activity
CSP5_RS02700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CSP5_RS02710	COG0137	argininosuccinate synthase activity
CSP5_RS02720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CSP5_RS02725	COG0189	ligase activity
CSP5_RS02730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CSP5_RS02735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CSP5_RS02740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CSP5_RS02785	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSP5_RS02790	COG0017	Asparaginyl-tRNA synthetase
CSP5_RS02815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSP5_RS02825	COG0187	DNA topoisomerase II activity
CSP5_RS02830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CSP5_RS02835	COG0460	homoserine dehydrogenase
CSP5_RS02845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CSP5_RS02860	COG1271	oxidase subunit
CSP5_RS03025	COG1012	belongs to the aldehyde dehydrogenase family
CSP5_RS03035	COG0003	Pfam Anion-transporting ATPase
CSP5_RS03040	COG0142	geranyltranstransferase activity
CSP5_RS03070	COG1960	acyl-CoA dehydrogenase activity
CSP5_RS03085	COG2222	sugar isomerase
CSP5_RS03100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSP5_RS03110	COG0396	ATPase activity
CSP5_RS03115	COG0719	Fe-S assembly protein
CSP5_RS03125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CSP5_RS03130	COG0822	iron-sulfur transferase activity
CSP5_RS03135	COG0419	ATPase involved in DNA repair
CSP5_RS03155	COG1473	amidohydrolase
CSP5_RS03200	COG1139	Iron-sulfur cluster binding protein
CSP5_RS03225	COG1960	acyl-CoA dehydrogenase activity
CSP5_RS03230	COG0004	ammonium transporteR
CSP5_RS03275	COG0626	cystathionine gamma-synthase activity
CSP5_RS03280	COG0083	homoserine kinase activity
CSP5_RS03305	COG2226	methyltransferase
CSP5_RS03310	COG2078	PFAM AMMECR1 domain protein
CSP5_RS03310	COG3885	ferrous iron binding
CSP5_RS03320	COG1063	alcohol dehydrogenase
CSP5_RS03325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CSP5_RS03330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CSP5_RS03335	COG0025	NhaP-type Na H and K H
CSP5_RS03340	COG4962	Type ii secretion system protein e
CSP5_RS03370	COG1131	(ABC) transporter
CSP5_RS03385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CSP5_RS03390	COG0006	proline dipeptidase activity
CSP5_RS03435	COG2271	Major facilitator Superfamily
CSP5_RS03460	COG0006	proline dipeptidase activity
CSP5_RS03525	COG0714	Associated with various cellular activities
CSP5_RS03540	COG0402	S-adenosylhomocysteine deaminase activity
CSP5_RS03545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CSP5_RS03555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CSP5_RS03575	COG0561	phosphatase activity
CSP5_RS03580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CSP5_RS03595	COG0167	dihydroorotate dehydrogenase activity
CSP5_RS03610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CSP5_RS03615	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CSP5_RS03620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CSP5_RS03705	COG1058	Belongs to the CinA family
CSP5_RS03705	COG1546	Belongs to the CinA family
CSP5_RS03725	COG0179	Fumarylacetoacetate (FAA) hydrolase
CSP5_RS03745	COG0588	phosphoglycerate mutase activity
CSP5_RS03770	COG0179	Fumarylacetoacetate (FAA) hydrolase
CSP5_RS03775	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CSP5_RS03785	COG1331	Highly conserved protein containing a thioredoxin domain
CSP5_RS03805	COG0631	protein serine/threonine phosphatase activity
CSP5_RS03810	COG2409	Drug exporters of the RND superfamily
CSP5_RS03820	COG0436	Aminotransferase
CSP5_RS03830	COG1051	belongs to the nudix hydrolase family
CSP5_RS03830	COG1056	cytidyltransferase-related domain
CSP5_RS03835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CSP5_RS03840	COG0442	prolyl-tRNA aminoacylation
CSP5_RS03855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CSP5_RS03860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CSP5_RS03880	COG1196	nuclear chromosome segregation
CSP5_RS03890	COG1234	tRNA 3'-trailer cleavage
CSP5_RS03895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CSP5_RS03905	COG0151	Belongs to the GarS family
CSP5_RS03915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CSP5_RS03920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CSP5_RS03965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CSP5_RS03970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CSP5_RS03975	COG3959	Transketolase, thiamine diphosphate binding domain
CSP5_RS03990	COG0531	amino acid
CSP5_RS03995	COG1175	transmembrane transport
CSP5_RS04000	COG3833	ABC-type maltose transport systems, permease component
CSP5_RS04005	COG3842	ATPase activity
CSP5_RS04015	COG3387	PFAM Glycoside hydrolase 15-related
CSP5_RS04035	COG0183	Belongs to the thiolase family
CSP5_RS04040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSP5_RS04045	COG1024	Enoyl-CoA hydratase
CSP5_RS04050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CSP5_RS04065	COG0492	ferredoxin-NADP+ reductase activity
CSP5_RS04070	COG3118	belongs to the thioredoxin family
CSP5_RS04080	COG0673	inositol 2-dehydrogenase activity
CSP5_RS04095	COG0038	chloride channel
CSP5_RS04105	COG0519	Catalyzes the synthesis of GMP from XMP
CSP5_RS04105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CSP5_RS04170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CSP5_RS04215	COG1592	Rubrerythrin
CSP5_RS04225	COG4555	ABC transporter
CSP5_RS04250	COG1064	alcohol dehydrogenase
CSP5_RS04325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CSP5_RS04345	COG0438	transferase activity, transferring glycosyl groups
CSP5_RS04355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CSP5_RS04355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CSP5_RS04360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CSP5_RS04360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CSP5_RS04390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CSP5_RS04405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CSP5_RS04415	COG0747	negative chemotaxis
CSP5_RS04420	COG0601	transmembrane transport
CSP5_RS04430	COG4608	Belongs to the ABC transporter superfamily
CSP5_RS04435	COG0444	Belongs to the ABC transporter superfamily
CSP5_RS04445	COG2723	6-phospho-beta-galactosidase activity
CSP5_RS04475	COG2217	Heavy metal translocating P-type atpase
CSP5_RS04485	COG2814	Major facilitator Superfamily
CSP5_RS04490	COG1846	Transcriptional regulator
CSP5_RS04495	COG4122	O-methyltransferase activity
CSP5_RS04530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CSP5_RS04605	COG1373	ATPase (AAA superfamily
CSP5_RS04635	COG1129	ABC transporter
CSP5_RS04640	COG1373	ATPase (AAA superfamily
CSP5_RS04685	COG0438	transferase activity, transferring glycosyl groups
CSP5_RS04690	COG0438	transferase activity, transferring glycosyl groups
CSP5_RS04720	COG0297	glycogen (starch) synthase activity
CSP5_RS04730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CSP5_RS04775	COG3328	transposase activity
CSP5_RS04910	COG1088	dTDP-glucose 4,6-dehydratase activity
CSP5_RS04945	COG0667	Aldo Keto reductase
CSP5_RS04950	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CSP5_RS04960	COG0477	Major facilitator Superfamily
CSP5_RS04975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CSP5_RS05000	COG1131	(ABC) transporter
CSP5_RS05015	COG0484	heat shock protein binding
CSP5_RS05035	COG4608	Belongs to the ABC transporter superfamily
CSP5_RS05040	COG0444	Belongs to the ABC transporter superfamily
CSP5_RS05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSP5_RS05050	COG0601	transmembrane transport
CSP5_RS05070	COG1469	GTP cyclohydrolase I activity
CSP5_RS05075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CSP5_RS05085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CSP5_RS05085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CSP5_RS05090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CSP5_RS05090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CSP5_RS05100	COG1078	dGTPase activity
CSP5_RS05110	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CSP5_RS05115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CSP5_RS05120	COG1492	cobalamin metabolic process
CSP5_RS05125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CSP5_RS05130	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CSP5_RS05145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CSP5_RS05185	COG0318	PFAM AMP-dependent synthetase and ligase
CSP5_RS05200	COG1216	Glycosyl transferase, family 2
CSP5_RS05205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CSP5_RS05225	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CSP5_RS05230	COG0540	Belongs to the ATCase OTCase family
CSP5_RS05240	COG2379	hydroxypyruvate reductase
CSP5_RS05245	COG1201	RNA secondary structure unwinding
CSP5_RS05255	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CSP5_RS05260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSP5_RS05275	COG0667	Aldo Keto reductase
CSP5_RS05290	COG0463	Glycosyl transferase, family 2
CSP5_RS05310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CSP5_RS05320	COG1215	transferase activity, transferring glycosyl groups
CSP5_RS05325	COG0463	Glycosyl transferase, family 2
CSP5_RS05340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CSP5_RS05345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CSP5_RS05365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CSP5_RS05385	COG1335	isochorismatase
CSP5_RS05390	COG0215	cysteine-tRNA ligase activity
CSP5_RS05430	COG0477	Major facilitator Superfamily
CSP5_RS05470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CSP5_RS05475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSP5_RS05485	COG0484	heat shock protein binding
CSP5_RS05490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CSP5_RS05500	COG0484	heat shock protein binding
CSP5_RS05520	COG0649	NAD binding
CSP5_RS05525	COG0651	ATP synthesis coupled electron transport
CSP5_RS05550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CSP5_RS05555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CSP5_RS05580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CSP5_RS05590	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CSP5_RS05600	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
CSP5_RS05620	COG0433	COG0433 Predicted ATPase
CSP5_RS05635	COG1607	acyl-coa hydrolase
CSP5_RS05640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CSP5_RS05660	COG3387	PFAM Glycoside hydrolase 15-related
CSP5_RS05685	COG2814	Major facilitator Superfamily
CSP5_RS05695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CSP5_RS05765	COG4974	Belongs to the 'phage' integrase family
CSP5_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
CSP5_RS05785	COG1309	transcriptional regulator
CSP5_RS05795	COG0318	PFAM AMP-dependent synthetase and ligase
CSP5_RS05805	COG0477	Major facilitator Superfamily
CSP5_RS05810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSP5_RS05815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSP5_RS05865	COG3842	ATPase activity
CSP5_RS05870	COG0395	ABC-type sugar transport system, permease component
CSP5_RS05895	COG1131	(ABC) transporter
CSP5_RS05925	COG3253	May function as heme-dependent peroxidase
CSP5_RS05930	COG0301	tRNA thio-modification
CSP5_RS05930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSP5_RS05965	COG1185	polyribonucleotide nucleotidyltransferase activity
CSP5_RS06005	COG1201	RNA secondary structure unwinding
CSP5_RS06040	COG0714	Associated with various cellular activities
CSP5_RS06060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CSP5_RS06070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSP5_RS06080	COG0148	phosphopyruvate hydratase activity
CSP5_RS06090	COG1881	PFAM PEBP family protein
CSP5_RS06145	COG1012	belongs to the aldehyde dehydrogenase family
CSP5_RS06175	COG0109	protoheme IX farnesyltransferase activity
CSP5_RS06245	COG0072	phenylalanine-tRNA ligase activity
CSP5_RS06255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CSP5_RS06265	COG1945	arginine decarboxylase activity
CSP5_RS06275	COG1028	Short-chain dehydrogenase reductase Sdr
CSP5_RS06275	COG3347	Dehydrogenase
CSP5_RS06285	COG0101	tRNA pseudouridine synthase activity
CSP5_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
CSP5_RS06300	COG1012	belongs to the aldehyde dehydrogenase family
CSP5_RS06310	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CSP5_RS06320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CSP5_RS06330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CSP5_RS06335	COG0105	UTP biosynthetic process
CSP5_RS06355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSP5_RS06360	COG1054	Belongs to the UPF0176 family
CSP5_RS06395	COG0412	Dienelactone hydrolase
CSP5_RS06400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CSP5_RS06405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CSP5_RS06415	COG0459	protein refolding
CSP5_RS06420	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CSP5_RS06430	COG0183	Belongs to the thiolase family
CSP5_RS06460	COG1846	Transcriptional regulator
CSP5_RS06485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CSP5_RS06500	COG0528	UMP kinase activity
CSP5_RS06505	COG1013	pyruvate-flavodoxin oxidoreductase activity
CSP5_RS06510	COG0674	pyruvate-flavodoxin oxidoreductase activity
CSP5_RS06510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CSP5_RS06520	COG0047	phosphoribosylformylglycinamidine synthase activity
CSP5_RS06535	COG1980	fructose-bisphosphate aldolase activity
CSP5_RS06540	COG2131	deaminase
CSP5_RS06545	COG0586	Pfam SNARE associated Golgi protein
CSP5_RS06600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CSP5_RS06605	COG0051	transcription antitermination factor activity, RNA binding
CSP5_RS06610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CSP5_RS06625	COG2808	Putative FMN-binding domain
CSP5_RS06635	COG1522	sequence-specific DNA binding
CSP5_RS06640	COG0017	Asparaginyl-tRNA synthetase
CSP5_RS06675	COG0708	Exodeoxyribonuclease III
CSP5_RS06710	COG0076	glutamate decarboxylase activity
CSP5_RS06720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CSP5_RS06725	COG1506	peptidase
CSP5_RS06725	COG4946	Tricorn protease homolog
CSP5_RS06725	COG0823	Involved in the tonB-independent uptake of proteins
CSP5_RS06735	COG0535	radical SAM domain protein
CSP5_RS06740	COG3547	Transposase (IS116 IS110 IS902 family)
CSP5_RS06765	COG0270	DNA (cytosine-5-)-methyltransferase activity
CSP5_RS06785	COG0732	type I restriction modification DNA specificity domain
CSP5_RS06790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CSP5_RS06820	COG0010	Belongs to the arginase family
CSP5_RS06855	COG0285	dihydrofolate synthase activity
CSP5_RS06865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CSP5_RS06875	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CSP5_RS06890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CSP5_RS06910	COG2149	membrane
CSP5_RS06915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CSP5_RS06920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSP5_RS06920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CSP5_RS06945	COG0667	Aldo Keto reductase
CSP5_RS06955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CSP5_RS06990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CSP5_RS07010	COG1047	Peptidyl-prolyl cis-trans
CSP5_RS07015	COG0469	pyruvate kinase activity
CSP5_RS07025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CSP5_RS07030	COG0134	indole-3-glycerol-phosphate synthase activity
CSP5_RS07035	COG0512	Glutamine amidotransferase of anthranilate synthase
CSP5_RS07040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CSP5_RS07045	COG0135	phosphoribosylanthranilate isomerase activity
CSP5_RS07060	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CSP5_RS07065	COG2226	methyltransferase
CSP5_RS07085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CSP5_RS07100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CSP5_RS07115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CSP5_RS07120	COG0483	inositol monophosphate 1-phosphatase activity
CSP5_RS07130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CSP5_RS07135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CSP5_RS07140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CSP5_RS07155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CSP5_RS07160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CSP5_RS07165	COG0181	hydroxymethylbilane synthase activity
CSP5_RS07180	COG1185	polyribonucleotide nucleotidyltransferase activity
CSP5_RS07200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CSP5_RS07210	COG0085	RNA polymerase activity
CSP5_RS07225	COG3590	peptidase
CSP5_RS07230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CSP5_RS07250	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CSP5_RS07305	COG1122	ATPase activity
CSP5_RS07345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CSP5_RS07355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CSP5_RS07415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CSP5_RS07425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CSP5_RS07440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CSP5_RS07465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CSP5_RS07470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CSP5_RS07475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CSP5_RS07480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CSP5_RS07485	COG0089	rRNA binding
CSP5_RS07495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CSP5_RS07510	COG1335	isochorismatase
CSP5_RS07520	COG0277	FAD linked oxidase domain protein
CSP5_RS07575	COG1619	proteins homologs of microcin C7 resistance protein MccF
CSP5_RS07590	COG2986	histidine ammonia-lyase
CSP5_RS07630	COG0519	Catalyzes the synthesis of GMP from XMP
CSP5_RS07645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CSP5_RS07665	COG0477	Major facilitator Superfamily
CSP5_RS07685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSP5_RS07715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSP5_RS07785	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CSP5_RS07790	COG1468	defense response to virus
CSP5_RS07790	COG1518	maintenance of DNA repeat elements
CSP5_RS07825	COG0366	Alpha amylase catalytic
CSP5_RS07830	COG3842	ATPase activity
CSP5_RS07835	COG3833	ABC-type maltose transport systems, permease component
CSP5_RS07840	COG1175	transmembrane transport
CSP5_RS07855	COG2723	6-phospho-beta-galactosidase activity
CSP5_RS07865	COG1725	Transcriptional regulator
CSP5_RS07870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CSP5_RS07875	COG2086	electron transfer activity
CSP5_RS07885	COG0644	oxidoreductase
CSP5_RS07920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CSP5_RS07925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CSP5_RS07935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CSP5_RS07940	COG4948	Mandelate Racemase Muconate Lactonizing
CSP5_RS07960	COG3842	ATPase activity
CSP5_RS07965	COG0395	ABC-type sugar transport system, permease component
CSP5_RS07980	COG1472	Belongs to the glycosyl hydrolase 3 family
CSP5_RS07990	COG3876	Protein conserved in bacteria
CSP5_RS08015	COG3876	Protein conserved in bacteria
CSP5_RS08020	COG1619	proteins homologs of microcin C7 resistance protein MccF
CSP5_RS08045	COG0154	amidase activity
CSP5_RS08055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CSP5_RS08060	COG4948	Mandelate Racemase Muconate Lactonizing
CSP5_RS08070	COG0667	Aldo Keto reductase
CSP5_RS08075	COG0758	DNA mediated transformation
CSP5_RS08095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CSP5_RS08120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CSP5_RS08125	COG0066	3-isopropylmalate dehydratase activity
CSP5_RS08130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CSP5_RS08135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CSP5_RS08140	COG2271	Major facilitator Superfamily
CSP5_RS08175	COG0358	DNA primase activity
CSP5_RS08180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CSP5_RS08185	COG0450	alkyl hydroperoxide reductase
CSP5_RS08200	COG0393	Putative heavy-metal-binding
CSP5_RS08205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CSP5_RS08210	COG0805	protein transport
CSP5_RS08230	COG1007	ATP synthesis coupled electron transport
CSP5_RS08235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CSP5_RS08240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CSP5_RS08245	COG0713	ATP synthesis coupled electron transport
CSP5_RS08255	COG0839	Belongs to the complex I subunit 6 family
CSP5_RS08260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CSP5_RS08265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CSP5_RS08270	COG0649	NAD binding
CSP5_RS08275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CSP5_RS08280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CSP5_RS08285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CSP5_RS08290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CSP5_RS08295	COG0252	asparaginase activity
CSP5_RS08305	COG1960	acyl-CoA dehydrogenase activity
CSP5_RS08320	COG1122	ATPase activity
CSP5_RS08335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CSP5_RS08340	COG0549	Belongs to the carbamate kinase family
CSP5_RS08350	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CSP5_RS08360	COG2814	Major facilitator Superfamily
CSP5_RS08400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CSP5_RS08410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CSP5_RS08445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSP5_RS08455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CSP5_RS08460	COG2255	four-way junction helicase activity
CSP5_RS08520	COG1192	Involved in chromosome partitioning
CSP5_RS08535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CSP5_RS08545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CSP5_RS08585	COG3328	transposase activity
CSP5_RS08650	COG3335	DDE superfamily endonuclease
CSP5_RS08685	COG2801	Transposase and inactivated derivatives
CSP5_RS08745	COG1431	PFAM Stem cell self-renewal protein Piwi
CSP5_RS08810	COG0235	Class ii aldolase
CSP5_RS08815	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CSP5_RS08820	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CSP5_RS08825	COG0006	proline dipeptidase activity
CSP5_RS08840	COG1116	anion transmembrane transporter activity
CSP5_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
CSP5_RS08870	COG0446	pyridine nucleotide-disulphide oxidoreductase
CSP5_RS08880	COG0640	Transcriptional regulator
CSP5_RS08915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CSP5_RS08920	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSP5_RS08920	COG1024	Enoyl-CoA hydratase
CSP5_RS08925	COG1573	uracil-dna glycosylase
CSP5_RS08940	COG0477	Major facilitator Superfamily
CSP5_RS08945	COG1132	(ABC) transporter
CSP5_RS08950	COG1132	(ABC) transporter
CSP5_RS08960	COG0183	Belongs to the thiolase family
CSP5_RS08965	COG1072	(Pantothenic acid kinase))
CSP5_RS08970	COG0601	transmembrane transport
CSP5_RS08975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSP5_RS08980	COG0444	Belongs to the ABC transporter superfamily
CSP5_RS08985	COG4608	Belongs to the ABC transporter superfamily
CSP5_RS09000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CSP5_RS09025	COG1131	(ABC) transporter
CSP5_RS09045	COG1027	Aspartate ammonia-lyase
CSP5_RS09060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CSP5_RS09080	COG2084	Dehydrogenase
CSP5_RS09085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CSP5_RS09090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CSP5_RS09115	COG0546	phosphoglycolate phosphatase activity
CSP5_RS09120	COG2124	cytochrome p450
CSP5_RS09140	COG2226	methyltransferase
CSP5_RS09180	COG0482	sulfurtransferase activity
CSP5_RS09195	COG2181	nitrate reductase activity
CSP5_RS09195	COG0247	lactate metabolic process
CSP5_RS09245	COG2086	electron transfer activity
CSP5_RS09255	COG1960	acyl-CoA dehydrogenase activity
CSP5_RS09260	COG1960	acyl-CoA dehydrogenase activity
CSP5_RS09270	COG2096	Adenosyltransferase
CSP5_RS09280	COG0366	Alpha amylase catalytic
CSP5_RS09285	COG0366	Alpha amylase catalytic
CSP5_RS09290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CSP5_RS09295	COG0489	protein tyrosine kinase activity
CSP5_RS09335	COG0372	Belongs to the citrate synthase family
CSP5_RS09350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CSP5_RS09350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CSP5_RS09385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CSP5_RS09390	COG0179	Fumarylacetoacetate (FAA) hydrolase
CSP5_RS09395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CSP5_RS09400	COG0284	orotidine-5'-phosphate decarboxylase activity
CSP5_RS09410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CSP5_RS09415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CSP5_RS09425	COG0823	Involved in the tonB-independent uptake of proteins
CSP5_RS09425	COG1506	peptidase
CSP5_RS09425	COG4946	Tricorn protease homolog
CSP5_RS09445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CSP5_RS09460	COG1695	Transcriptional regulator
CSP5_RS09485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CSP5_RS09495	COG0425	Belongs to the sulfur carrier protein TusA family
CSP5_RS09515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CSP5_RS09525	COG2271	Major facilitator Superfamily
CSP5_RS09540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CSP5_RS09585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CSP5_RS09610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CSP5_RS09615	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CSP5_RS09620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism