locus-tag	class	description
RR42_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RR42_RS00025	COG1401	restriction endodeoxyribonuclease activity
RR42_RS00045	COG1002	Type II restriction enzyme, methylase subunits
RR42_RS00050	COG1061	Type III restriction enzyme res subunit
RR42_RS00055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RR42_RS00135	COG3210	domain, Protein
RR42_RS00150	COG3210	domain, Protein
RR42_RS00215	COG0154	amidase activity
RR42_RS00235	COG2733	membrane
RR42_RS00250	COG1802	Transcriptional regulator
RR42_RS00260	COG0765	amino acid transport
RR42_RS00270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS00275	COG2721	sulfolactate sulfo-lyase activity
RR42_RS00280	COG0386	Belongs to the glutathione peroxidase family
RR42_RS00295	COG0513	Belongs to the DEAD box helicase family
RR42_RS00320	COG0517	IMP dehydrogenase activity
RR42_RS00325	COG0477	Major facilitator Superfamily
RR42_RS00335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RR42_RS00335	COG0426	domain, Protein
RR42_RS00340	COG0625	glutathione transferase activity
RR42_RS00375	COG2271	Major facilitator Superfamily
RR42_RS00380	COG1802	Transcriptional regulator
RR42_RS00390	COG1473	amidohydrolase
RR42_RS00395	COG2207	Transcriptional regulator
RR42_RS00400	COG2223	nitrite transmembrane transporter activity
RR42_RS00410	COG1846	Transcriptional regulator
RR42_RS00415	COG0697	spore germination
RR42_RS00430	COG0745	RESPONSE REGULATOR receiver
RR42_RS00435	COG0745	RESPONSE REGULATOR receiver
RR42_RS00445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS00450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RR42_RS00455	COG2894	cell division
RR42_RS00460	COG0850	regulation of cytokinetic process
RR42_RS00465	COG0598	Magnesium transport protein CorA
RR42_RS00480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RR42_RS00485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RR42_RS00490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RR42_RS00495	COG2205	protein histidine kinase activity
RR42_RS00500	COG0745	RESPONSE REGULATOR receiver
RR42_RS00560	COG0772	Belongs to the SEDS family
RR42_RS00565	COG0768	penicillin binding
RR42_RS00575	COG1792	Involved in formation and maintenance of cell shape
RR42_RS00580	COG1077	Cell shape determining protein MreB Mrl
RR42_RS00585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RR42_RS00590	COG0154	amidase activity
RR42_RS00605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RR42_RS00615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RR42_RS00620	COG0583	DNA-binding transcription factor activity
RR42_RS00630	COG0321	lipoyl(octanoyl) transferase activity
RR42_RS00635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RR42_RS00640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RR42_RS00645	COG1984	allophanate hydrolase subunit 2
RR42_RS00650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RR42_RS00665	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RR42_RS00690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RR42_RS00695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RR42_RS00695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RR42_RS00700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RR42_RS00710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RR42_RS00755	COG2267	carboxylic ester hydrolase activity
RR42_RS00775	COG0646	methionine synthase
RR42_RS00775	COG1410	methionine synthase
RR42_RS00785	COG2197	response regulator
RR42_RS00790	COG2201	protein-glutamate methylesterase activity
RR42_RS00825	COG0018	arginyl-trna synthetase
RR42_RS00835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RR42_RS00840	COG4221	oxidoreductase activity
RR42_RS00845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RR42_RS00860	COG0789	Transcriptional regulator
RR42_RS00870	COG1960	acyl-CoA dehydrogenase activity
RR42_RS00875	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RR42_RS00880	COG0288	reversible hydration of carbon dioxide
RR42_RS00885	COG0183	Belongs to the thiolase family
RR42_RS00895	COG1960	acyl-CoA dehydrogenase activity
RR42_RS00910	COG3012	SEC-C Motif Domain Protein
RR42_RS00915	COG0625	glutathione transferase activity
RR42_RS00930	COG0156	8-amino-7-oxononanoate synthase activity
RR42_RS00935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RR42_RS00940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RR42_RS00945	COG4770	biotin carboxylase activity
RR42_RS00950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RR42_RS00975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RR42_RS00990	COG2188	Transcriptional regulator
RR42_RS00995	COG0471	metal ion transport
RR42_RS01015	COG4206	TonB-dependent receptor
RR42_RS01040	COG0523	cobalamin synthesis protein
RR42_RS01050	COG0596	Alpha beta hydrolase
RR42_RS01060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RR42_RS01065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RR42_RS01085	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RR42_RS01095	COG2847	Copper chaperone PCu(A)C
RR42_RS01100	COG0583	DNA-binding transcription factor activity
RR42_RS01120	COG1595	DNA-templated transcription, initiation
RR42_RS01125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RR42_RS01135	COG1309	transcriptional regulator
RR42_RS01145	COG4452	Inner membrane protein CreD
RR42_RS01150	COG2205	protein histidine kinase activity
RR42_RS01155	COG0745	RESPONSE REGULATOR receiver
RR42_RS01160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RR42_RS01185	COG2223	nitrite transmembrane transporter activity
RR42_RS01190	COG0501	Belongs to the peptidase M48B family
RR42_RS01210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RR42_RS01215	COG2944	sequence-specific DNA binding
RR42_RS01220	COG0708	Exodeoxyribonuclease III
RR42_RS01225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RR42_RS01230	COG4689	acetoacetate decarboxylase
RR42_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS01245	COG2326	polyphosphate kinase activity
RR42_RS01250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RR42_RS01265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RR42_RS01285	COG1960	acyl-CoA dehydrogenase activity
RR42_RS01290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RR42_RS01305	COG2022	thiamine diphosphate biosynthetic process
RR42_RS01335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RR42_RS01350	COG0439	Biotin carboxylase
RR42_RS01355	COG0511	ligase activity, forming carbon-carbon bonds
RR42_RS01370	COG0351	phosphomethylpyrimidine kinase
RR42_RS01375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RR42_RS01380	COG1950	PFAM Membrane protein of
RR42_RS01385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RR42_RS01400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RR42_RS01420	COG0617	tRNA 3'-terminal CCA addition
RR42_RS01445	COG0037	tRNA processing
RR42_RS01455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RR42_RS01460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RR42_RS01465	COG2205	protein histidine kinase activity
RR42_RS01480	COG5001	Diguanylate cyclase
RR42_RS01480	COG5002	protein histidine kinase activity
RR42_RS01480	COG3447	MASE1 domain protein
RR42_RS01500	COG2050	protein possibly involved in aromatic compounds catabolism
RR42_RS01515	COG1051	belongs to the nudix hydrolase family
RR42_RS01515	COG1056	cytidyltransferase-related domain
RR42_RS01520	COG0583	DNA-binding transcription factor activity
RR42_RS01535	COG0066	3-isopropylmalate dehydratase activity
RR42_RS01570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RR42_RS01575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RR42_RS01585	COG0531	amino acid
RR42_RS01600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RR42_RS01600	COG1703	isobutyryl-CoA mutase activity
RR42_RS01600	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RR42_RS01605	COG0537	adenosine 5'-monophosphoramidase activity
RR42_RS01610	COG1250	3-hydroxyacyl-CoA dehydrogenase
RR42_RS01615	COG0840	transmembrane signaling receptor activity
RR42_RS01625	COG1022	Amp-dependent synthetase and ligase
RR42_RS01660	COG2832	Protein of unknown function (DUF454)
RR42_RS01670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RR42_RS01675	COG2921	Belongs to the UPF0250 family
RR42_RS01680	COG1686	Belongs to the peptidase S11 family
RR42_RS01685	COG2945	thiolester hydrolase activity
RR42_RS01690	COG3411	Ferredoxin
RR42_RS01695	COG1301	dicarboxylic acid transport
RR42_RS01705	COG2204	response regulator
RR42_RS01710	COG2986	histidine ammonia-lyase
RR42_RS01715	COG0210	DNA helicase
RR42_RS01735	COG1280	lysine exporter protein (LysE YggA)
RR42_RS01745	COG2960	long-chain fatty acid transporting porin activity
RR42_RS01760	COG0004	ammonium transporteR
RR42_RS01780	COG0189	ligase activity
RR42_RS01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RR42_RS01795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RR42_RS01805	COG0709	Synthesizes selenophosphate from selenide and ATP
RR42_RS01810	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RR42_RS01815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RR42_RS01820	COG0793	Belongs to the peptidase S41A family
RR42_RS01825	COG0588	phosphoglycerate mutase activity
RR42_RS01830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RR42_RS01835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RR42_RS01840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RR42_RS01845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RR42_RS01850	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS01865	COG2226	methyltransferase
RR42_RS01880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RR42_RS01915	COG1612	heme a metabolic process
RR42_RS01920	COG0109	protoheme IX farnesyltransferase activity
RR42_RS01925	COG1999	signal sequence binding
RR42_RS01930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RR42_RS01935	COG1741	Belongs to the pirin family
RR42_RS01940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RR42_RS01945	COG1116	anion transmembrane transporter activity
RR42_RS01950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RR42_RS01955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RR42_RS01970	COG0625	glutathione transferase activity
RR42_RS01980	COG0612	Peptidase, M16
RR42_RS01985	COG0612	Peptidase, M16
RR42_RS01990	COG0742	ribosomal rna small subunit methyltransferase
RR42_RS01995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RR42_RS02000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RR42_RS02005	COG0193	aminoacyl-tRNA hydrolase activity
RR42_RS02010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RR42_RS02015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RR42_RS02025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RR42_RS02030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RR42_RS02040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RR42_RS02050	COG1194	a g-specific adenine glycosylase
RR42_RS02060	COG1660	Displays ATPase and GTPase activities
RR42_RS02070	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RR42_RS02080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RR42_RS02085	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RR42_RS02090	COG1137	ATPase activity
RR42_RS02120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RR42_RS02125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RR42_RS02130	COG1283	sodium-dependent phosphate transmembrane transporter activity
RR42_RS02150	COG2814	Major facilitator Superfamily
RR42_RS02155	COG0629	single-stranded DNA binding
RR42_RS02165	COG0583	DNA-binding transcription factor activity
RR42_RS02175	COG0028	Belongs to the TPP enzyme family
RR42_RS02185	COG1053	succinate dehydrogenase
RR42_RS02230	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RR42_RS02235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RR42_RS02240	COG2721	sulfolactate sulfo-lyase activity
RR42_RS02245	COG2721	sulfolactate sulfo-lyase activity
RR42_RS02250	COG2188	Transcriptional regulator
RR42_RS02260	COG1858	cytochrome C peroxidase
RR42_RS02265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RR42_RS02275	COG0436	Aminotransferase
RR42_RS02285	COG0842	Transport permease protein
RR42_RS02290	COG1131	(ABC) transporter
RR42_RS02310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RR42_RS02310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RR42_RS02315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RR42_RS02320	COG1877	trehalose-phosphatase activity
RR42_RS02330	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RR42_RS02340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RR42_RS02355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RR42_RS02375	COG1238	metal cluster binding
RR42_RS02390	COG4178	(ABC) transporter
RR42_RS02400	COG2226	methyltransferase
RR42_RS02415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RR42_RS02445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RR42_RS02450	COG0477	Major facilitator Superfamily
RR42_RS02470	COG0494	nUDIX hydrolase
RR42_RS02475	COG3568	Endonuclease Exonuclease Phosphatase
RR42_RS02490	COG1763	Mo-molybdopterin cofactor biosynthetic process
RR42_RS02495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RR42_RS02505	COG1960	acyl-CoA dehydrogenase activity
RR42_RS02510	COG1250	3-hydroxyacyl-CoA dehydrogenase
RR42_RS02510	COG1024	Enoyl-CoA hydratase
RR42_RS02515	COG0183	Belongs to the thiolase family
RR42_RS02525	COG1024	Enoyl-CoA hydratase
RR42_RS02530	COG1607	acyl-coa hydrolase
RR42_RS02535	COG5265	(ABC) transporter
RR42_RS02545	COG1116	anion transmembrane transporter activity
RR42_RS02550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RR42_RS02555	COG1522	sequence-specific DNA binding
RR42_RS02570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RR42_RS02580	COG0765	amino acid transport
RR42_RS02585	COG0765	amino acid transport
RR42_RS02590	COG1126	abc transporter atp-binding protein
RR42_RS02595	COG0121	glutamine amidotransferase
RR42_RS02600	COG0473	3-isopropylmalate dehydrogenase activity
RR42_RS02610	COG0418	dihydroorotase activity
RR42_RS02620	COG1765	OsmC-like protein
RR42_RS02625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RR42_RS02630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RR42_RS02645	COG0316	Belongs to the HesB IscA family
RR42_RS02660	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RR42_RS02665	COG0739	heme binding
RR42_RS02670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RR42_RS02675	COG1490	D-aminoacyl-tRNA deacylase activity
RR42_RS02680	COG1881	PFAM PEBP family protein
RR42_RS02700	COG2255	four-way junction helicase activity
RR42_RS02705	COG0632	four-way junction helicase activity
RR42_RS02710	COG0584	glycerophosphoryl diester phosphodiesterase
RR42_RS02715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RR42_RS02720	COG0138	bifunctional purine biosynthesis protein purh
RR42_RS02725	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RR42_RS02735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RR42_RS02745	COG0006	proline dipeptidase activity
RR42_RS02765	COG3178	'Phosphotransferase
RR42_RS02770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RR42_RS02775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RR42_RS02780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RR42_RS02785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RR42_RS02800	COG0346	lactoylglutathione lyase activity
RR42_RS02810	COG0204	Acyl-transferase
RR42_RS02815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RR42_RS02820	COG0751	glycine-tRNA ligase activity
RR42_RS02830	COG0752	glycyl-tRNA synthetase alpha subunit
RR42_RS02835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RR42_RS02840	COG4535	Mg2 and Co2 transporter CorC
RR42_RS02845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RR42_RS02850	COG1702	phosphate starvation-inducible protein PhoH
RR42_RS02855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RR42_RS02865	COG0038	chloride channel
RR42_RS02870	COG0513	Belongs to the DEAD box helicase family
RR42_RS02890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RR42_RS02900	COG0583	DNA-binding transcription factor activity
RR42_RS02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RR42_RS02930	COG1522	sequence-specific DNA binding
RR42_RS02935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RR42_RS02955	COG3052	prosthetic group binding
RR42_RS02960	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
RR42_RS03010	COG0183	Belongs to the thiolase family
RR42_RS03015	COG1024	Enoyl-CoA hydratase
RR42_RS03045	COG1464	Belongs to the NlpA lipoprotein family
RR42_RS03070	COG0642	Histidine kinase
RR42_RS03080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RR42_RS03085	COG2137	regulation of response to DNA damage stimulus
RR42_RS03095	COG0045	succinate-CoA ligase (ADP-forming) activity
RR42_RS03100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RR42_RS03105	COG0861	Integral membrane protein TerC family
RR42_RS03110	COG4969	Belongs to the N-Me-Phe pilin family
RR42_RS03140	COG0315	cyclic pyranopterin monophosphate synthase activity
RR42_RS03155	COG0429	hydrolase of the alpha beta-hydrolase fold
RR42_RS03165	COG0859	PFAM glycosyl transferase family 9
RR42_RS03175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RR42_RS03200	COG0126	phosphoglycerate kinase activity
RR42_RS03210	COG0469	pyruvate kinase activity
RR42_RS03220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RR42_RS03225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RR42_RS03230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RR42_RS03235	COG0009	L-threonylcarbamoyladenylate synthase
RR42_RS03280	COG0583	DNA-binding transcription factor activity
RR42_RS03305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RR42_RS03310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RR42_RS03335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RR42_RS03340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RR42_RS03345	COG4974	Belongs to the 'phage' integrase family
RR42_RS03350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RR42_RS03360	COG1129	ABC transporter
RR42_RS03365	COG1172	Belongs to the binding-protein-dependent transport system permease family
RR42_RS03370	COG1879	ABC-type sugar transport system periplasmic component
RR42_RS03375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RR42_RS03380	COG0166	Belongs to the GPI family
RR42_RS03405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RR42_RS03410	COG0802	atpase or kinase
RR42_RS03415	COG0860	N-Acetylmuramoyl-L-alanine amidase
RR42_RS03425	COG0583	DNA-binding transcription factor activity
RR42_RS03430	COG2226	methyltransferase
RR42_RS03445	COG0563	adenylate kinase activity
RR42_RS03450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RR42_RS03455	COG2835	tetraacyldisaccharide 4'-kinase activity
RR42_RS03460	COG1663	tetraacyldisaccharide 4'-kinase activity
RR42_RS03470	COG0811	peptide transport
RR42_RS03475	COG1570	exodeoxyribonuclease VII activity
RR42_RS03595	COG0583	DNA-binding transcription factor activity
RR42_RS03605	COG0435	Glutathione S-transferase
RR42_RS03610	COG0596	Alpha beta hydrolase
RR42_RS03620	COG1560	Kdo2-lipid A biosynthetic process
RR42_RS03630	COG1278	Cold shock
RR42_RS03665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RR42_RS03705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RR42_RS03710	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RR42_RS03720	COG0443	Heat shock 70 kDa protein
RR42_RS03745	COG1910	domain protein
RR42_RS03760	COG3383	formate dehydrogenase (NAD+) activity
RR42_RS03765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RR42_RS03775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RR42_RS03780	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RR42_RS03785	COG0471	metal ion transport
RR42_RS03795	COG2365	Tyrosine phosphatase family
RR42_RS03800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RR42_RS03815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RR42_RS03835	COG4149	molybdate abc transporter
RR42_RS03840	COG0725	ABC transporter, periplasmic molybdate-binding protein
RR42_RS03860	COG1609	Transcriptional regulator
RR42_RS03865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RR42_RS03885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RR42_RS03885	COG3008	intermembrane lipid transfer
RR42_RS03890	COG2995	paraquat-inducible protein a
RR42_RS03900	COG0628	permease
RR42_RS03905	COG0583	DNA-binding transcription factor activity
RR42_RS03935	COG2233	PERMEase
RR42_RS03940	COG0517	IMP dehydrogenase activity
RR42_RS03940	COG1125	glycine betaine transport
RR42_RS03950	COG1522	sequence-specific DNA binding
RR42_RS03955	COG1834	amidinotransferase
RR42_RS03960	COG2423	ornithine cyclodeaminase activity
RR42_RS03990	COG1301	dicarboxylic acid transport
RR42_RS03995	COG3447	MASE1 domain protein
RR42_RS03995	COG5001	Diguanylate cyclase
RR42_RS03995	COG5002	protein histidine kinase activity
RR42_RS04025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RR42_RS04025	COG2010	Cytochrome c
RR42_RS04070	COG0604	alcohol dehydrogenase
RR42_RS04070	COG4221	oxidoreductase activity
RR42_RS04070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RR42_RS04070	COG3321	synthase
RR42_RS04075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RR42_RS04080	COG0459	protein refolding
RR42_RS04130	COG4964	Belongs to the GSP D family
RR42_RS04170	COG0463	Glycosyl transferase, family 2
RR42_RS04205	COG0583	DNA-binding transcription factor activity
RR42_RS04225	COG1704	LemA family
RR42_RS04230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RR42_RS04235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RR42_RS04240	COG1773	rubredoxin
RR42_RS04265	COG0643	Histidine kinase
RR42_RS04265	COG2198	Histidine kinase
RR42_RS04270	COG2271	Major facilitator Superfamily
RR42_RS04280	COG1012	belongs to the aldehyde dehydrogenase family
RR42_RS04285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RR42_RS04290	COG3038	cytochrome b561
RR42_RS04300	COG0347	Belongs to the P(II) protein family
RR42_RS04305	COG2860	membrane
RR42_RS04310	COG2840	Smr protein MutS2
RR42_RS04315	COG0492	ferredoxin-NADP+ reductase activity
RR42_RS04320	COG1674	ftsk spoiiie
RR42_RS04325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RR42_RS04335	COG1840	ABC-type Fe3 transport system, periplasmic component
RR42_RS04345	COG1176	ABC-type spermidine putrescine transport system, permease component I
RR42_RS04350	COG3842	ATPase activity
RR42_RS04355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RR42_RS04360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RR42_RS04375	COG1253	flavin adenine dinucleotide binding
RR42_RS04380	COG0583	DNA-binding transcription factor activity
RR42_RS04385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RR42_RS04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS04395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS04400	COG0765	amino acid transport
RR42_RS04405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RR42_RS04405	COG0189	ligase activity
RR42_RS04410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RR42_RS04410	COG0189	ligase activity
RR42_RS04415	COG1132	(ABC) transporter
RR42_RS04435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RR42_RS04455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RR42_RS04465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RR42_RS04470	COG0287	Prephenate dehydrogenase
RR42_RS04475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RR42_RS04485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RR42_RS04495	COG0776	regulation of translation
RR42_RS04505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RR42_RS04515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RR42_RS04520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RR42_RS04530	COG2233	PERMEase
RR42_RS04540	COG2951	lytic endotransglycosylase activity
RR42_RS04545	COG0123	including yeast histone deacetylase and acetoin utilization protein
RR42_RS04550	COG1024	Enoyl-CoA hydratase
RR42_RS04555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RR42_RS04560	COG2011	ABC-type metal ion transport system permease component
RR42_RS04580	COG1960	acyl-CoA dehydrogenase activity
RR42_RS04585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RR42_RS04600	COG0583	DNA-binding transcription factor activity
RR42_RS04620	COG0228	four-way junction DNA binding
RR42_RS04625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RR42_RS04630	COG0336	Belongs to the RNA methyltransferase TrmD family
RR42_RS04635	COG0335	large ribosomal subunit rRNA binding
RR42_RS04645	COG1054	Belongs to the UPF0176 family
RR42_RS04670	COG1132	(ABC) transporter
RR42_RS04695	COG1309	transcriptional regulator
RR42_RS04700	COG1530	ribonuclease E activity
RR42_RS04705	COG0424	maF-like protein
RR42_RS04710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RR42_RS04715	COG0799	negative regulation of ribosome biogenesis
RR42_RS04725	COG0408	coproporphyrinogen oxidase activity
RR42_RS04730	COG0151	Belongs to the GarS family
RR42_RS04735	COG0217	transcriptional regulatory protein
RR42_RS04740	COG0433	COG0433 Predicted ATPase
RR42_RS04745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RR42_RS04760	COG0697	spore germination
RR42_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS04770	COG1803	Methylglyoxal synthase
RR42_RS04795	COG4603	Belongs to the binding-protein-dependent transport system permease family
RR42_RS04800	COG3845	ABC transporter
RR42_RS04805	COG1741	Belongs to the pirin family
RR42_RS04835	COG2186	Transcriptional regulator
RR42_RS04845	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS04880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RR42_RS04885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RR42_RS04890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RR42_RS04900	COG0515	serine threonine protein kinase
RR42_RS04900	COG4991	sh3 domain protein
RR42_RS04900	COG3064	Membrane
RR42_RS04905	COG1561	YicC-like family, N-terminal region
RR42_RS04910	COG0194	GDP metabolic process
RR42_RS04915	COG1758	RNA polymerase activity
RR42_RS04920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RR42_RS04960	COG3128	pkhd-type hydroxylase
RR42_RS04975	COG3706	GGDEF domain
RR42_RS04985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RR42_RS05000	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RR42_RS05025	COG3781	membrane
RR42_RS05040	COG0405	Gamma-glutamyltransferase
RR42_RS05055	COG0488	(ABC) transporter
RR42_RS05070	COG1113	amino acid transport
RR42_RS05095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RR42_RS05105	COG3971	2-oxopent-4-enoate hydratase activity
RR42_RS05120	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS05135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RR42_RS05155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RR42_RS05165	COG1802	Transcriptional regulator
RR42_RS05195	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RR42_RS05200	COG0308	aminopeptidase N
RR42_RS05210	COG0280	phosphate acetyltransferase
RR42_RS05210	COG0281	malic enzyme
RR42_RS05230	COG0583	DNA-binding transcription factor activity
RR42_RS05250	COG3648	Uricase
RR42_RS05250	COG3195	allantoin biosynthetic process
RR42_RS05260	COG2233	PERMEase
RR42_RS05270	COG2351	hydroxyisourate hydrolase activity
RR42_RS05300	COG4771	TonB-dependent receptor
RR42_RS05320	COG0402	S-adenosylhomocysteine deaminase activity
RR42_RS05325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RR42_RS05335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RR42_RS05370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RR42_RS05400	COG0438	transferase activity, transferring glycosyl groups
RR42_RS05435	COG0028	Belongs to the TPP enzyme family
RR42_RS05440	COG0440	acetolactate synthase activity
RR42_RS05445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RR42_RS05450	COG0688	phosphatidylethanolamine metabolic process
RR42_RS05455	COG1183	phosphatidylcholine synthase activity
RR42_RS05460	COG1652	LysM domain
RR42_RS05465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RR42_RS05475	COG0683	leucine binding
RR42_RS05480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RR42_RS05485	COG1185	polyribonucleotide nucleotidyltransferase activity
RR42_RS05495	COG0149	triose-phosphate isomerase activity
RR42_RS05510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RR42_RS05515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RR42_RS05520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RR42_RS05525	COG0649	NAD binding
RR42_RS05540	COG1034	ATP synthesis coupled electron transport
RR42_RS05545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RR42_RS05550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RR42_RS05560	COG0713	ATP synthesis coupled electron transport
RR42_RS05575	COG1007	ATP synthesis coupled electron transport
RR42_RS05595	COG1960	acyl-CoA dehydrogenase activity
RR42_RS05600	COG1960	acyl-CoA dehydrogenase activity
RR42_RS05620	COG0596	Alpha beta hydrolase
RR42_RS05625	COG2072	flavoprotein involved in K transport
RR42_RS05655	COG0829	nickel cation binding
RR42_RS05660	COG0831	urea catabolic process
RR42_RS05670	COG0832	Belongs to the urease beta subunit family
RR42_RS05675	COG0804	urea catabolic process
RR42_RS05680	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RR42_RS05685	COG0830	nickel cation binding
RR42_RS05690	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RR42_RS05710	COG0625	glutathione transferase activity
RR42_RS05715	COG1960	acyl-CoA dehydrogenase activity
RR42_RS05730	COG1595	DNA-templated transcription, initiation
RR42_RS05735	COG2304	oxidoreductase activity
RR42_RS05740	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS05755	COG1024	Enoyl-CoA hydratase
RR42_RS05760	COG1250	3-hydroxyacyl-CoA dehydrogenase
RR42_RS05765	COG0625	glutathione transferase activity
RR42_RS05770	COG0436	Aminotransferase
RR42_RS05780	COG3022	response to hydroperoxide
RR42_RS05785	COG2866	Carboxypeptidase
RR42_RS05800	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS05805	COG0583	DNA-binding transcription factor activity
RR42_RS05810	COG1595	DNA-templated transcription, initiation
RR42_RS05860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RR42_RS05875	COG0312	modulator of DNA gyrase
RR42_RS05880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RR42_RS05890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RR42_RS05900	COG1404	Belongs to the peptidase S8 family
RR42_RS05910	COG0497	DNA recombination
RR42_RS05915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RR42_RS05920	COG1420	regulation of RNA biosynthetic process
RR42_RS05925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RR42_RS05940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RR42_RS05965	COG0778	Nitroreductase
RR42_RS05970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RR42_RS05975	COG2878	Part of a membrane complex involved in electron transport
RR42_RS05980	COG1309	transcriptional regulator
RR42_RS05995	COG0556	nucleotide-excision repair
RR42_RS06010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RR42_RS06025	COG1104	cysteine desulfurase activity
RR42_RS06030	COG0822	iron-sulfur transferase activity
RR42_RS06035	COG0316	Belongs to the HesB IscA family
RR42_RS06045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RR42_RS06050	COG0443	Heat shock 70 kDa protein
RR42_RS06060	COG2975	iron-sulfur cluster assembly
RR42_RS06070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RR42_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS06080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RR42_RS06085	COG1388	LysM domain
RR42_RS06085	COG4942	peptidase
RR42_RS06090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RR42_RS06105	COG1136	(ABC) transporter
RR42_RS06110	COG0084	hydrolase, TatD family'
RR42_RS06130	COG3265	gluconokinase activity
RR42_RS06135	COG2308	Evidence 4 Homologs of previously reported genes of
RR42_RS06160	COG0504	CTP synthase activity
RR42_RS06165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RR42_RS06175	COG0148	phosphopyruvate hydratase activity
RR42_RS06180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RR42_RS06190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RR42_RS06200	COG2833	Protein of unknown function (DUF455)
RR42_RS06210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RR42_RS06215	COG2267	carboxylic ester hydrolase activity
RR42_RS06220	COG0492	ferredoxin-NADP+ reductase activity
RR42_RS06225	COG0613	PHP domain protein
RR42_RS06230	COG0009	L-threonylcarbamoyladenylate synthase
RR42_RS06235	COG1994	Peptidase M50
RR42_RS06240	COG0180	Tryptophanyl-tRNA synthetase
RR42_RS06250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RR42_RS06255	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RR42_RS06260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RR42_RS06270	COG2850	peptidyl-arginine hydroxylation
RR42_RS06285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RR42_RS06310	COG0483	inositol monophosphate 1-phosphatase activity
RR42_RS06325	COG1045	serine acetyltransferase
RR42_RS06330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RR42_RS06340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RR42_RS06345	COG0457	Tetratricopeptide repeat
RR42_RS06350	COG0215	cysteine-tRNA ligase activity
RR42_RS06355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RR42_RS06360	COG0825	malonyl-CoA metabolic process
RR42_RS06365	COG0037	tRNA processing
RR42_RS06370	COG0527	aspartate kinase activity
RR42_RS06385	COG1902	pentaerythritol trinitrate reductase activity
RR42_RS06390	COG0583	DNA-binding transcription factor activity
RR42_RS06395	COG1309	transcriptional regulator
RR42_RS06400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RR42_RS06405	COG3162	membrane
RR42_RS06425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RR42_RS06435	COG0277	FAD linked oxidase domain protein
RR42_RS06450	COG1295	ribonuclease BN
RR42_RS06460	COG2267	carboxylic ester hydrolase activity
RR42_RS06485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RR42_RS06490	COG2814	Major facilitator Superfamily
RR42_RS06495	COG0579	oxidoreductase
RR42_RS06500	COG2186	Transcriptional regulator
RR42_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS06530	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RR42_RS06530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RR42_RS06535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RR42_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS06580	COG0251	oxidation-reduction process
RR42_RS06585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RR42_RS06600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RR42_RS06605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RR42_RS06610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RR42_RS06615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RR42_RS06620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RR42_RS06625	COG0072	phenylalanine-tRNA ligase activity
RR42_RS06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS06630	COG0776	regulation of translation
RR42_RS06835	COG2974	May be involved in recombination
RR42_RS06930	COG1674	ftsk spoiiie
RR42_RS06960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RR42_RS06995	COG2755	lipolytic protein G-D-S-L family
RR42_RS06995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RR42_RS07270	COG2902	Dehydrogenase
RR42_RS07275	COG0427	acetyl-CoA hydrolase
RR42_RS07285	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS07320	COG1846	Transcriptional regulator
RR42_RS07330	COG2188	Transcriptional regulator
RR42_RS07335	COG2223	nitrite transmembrane transporter activity
RR42_RS07340	COG0339	signal peptide processing
RR42_RS07345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RR42_RS07355	COG4566	intracellular signal transduction
RR42_RS07365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RR42_RS07370	COG0508	dehydrogenase complex catalyzes the overall conversion of
RR42_RS07380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RR42_RS07390	COG0123	including yeast histone deacetylase and acetoin utilization protein
RR42_RS07400	COG0824	Thioesterase
RR42_RS07410	COG1686	Belongs to the peptidase S11 family
RR42_RS07425	COG1414	Transcriptional regulator
RR42_RS07445	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RR42_RS07460	COG0667	Aldo Keto reductase
RR42_RS07465	COG0167	dihydroorotate dehydrogenase activity
RR42_RS07470	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RR42_RS07475	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RR42_RS07555	COG3158	transport of potassium into the cell
RR42_RS07565	COG2183	response to ionizing radiation
RR42_RS07580	COG1199	ATP-dependent helicase activity
RR42_RS07590	COG0564	pseudouridine synthase activity
RR42_RS07605	COG3243	poly(R)-hydroxyalkanoic acid synthase
RR42_RS07610	COG0183	Belongs to the thiolase family
RR42_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS07625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RR42_RS07640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RR42_RS07645	COG0183	Belongs to the thiolase family
RR42_RS07660	COG0560	Phosphoserine phosphatase
RR42_RS07675	COG3119	arylsulfatase activity
RR42_RS07685	COG1473	amidohydrolase
RR42_RS07695	COG0583	DNA-binding transcription factor activity
RR42_RS07715	COG1335	isochorismatase
RR42_RS07725	COG1136	(ABC) transporter
RR42_RS07760	COG1477	protein flavinylation
RR42_RS07775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS07795	COG0840	transmembrane signaling receptor activity
RR42_RS07800	COG1414	Transcriptional regulator
RR42_RS07805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS07810	COG0765	amino acid transport
RR42_RS07815	COG1126	abc transporter atp-binding protein
RR42_RS07820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RR42_RS07830	COG1473	amidohydrolase
RR42_RS07845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RR42_RS07850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RR42_RS07855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RR42_RS07865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RR42_RS07870	COG0450	alkyl hydroperoxide reductase
RR42_RS07925	COG0154	amidase activity
RR42_RS07930	COG0444	Belongs to the ABC transporter superfamily
RR42_RS07935	COG4608	Belongs to the ABC transporter superfamily
RR42_RS07940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RR42_RS07945	COG0601	transmembrane transport
RR42_RS07950	COG0747	negative chemotaxis
RR42_RS07965	COG1802	Transcriptional regulator
RR42_RS08075	COG0419	ATPase involved in DNA repair
RR42_RS08080	COG1674	ftsk spoiiie
RR42_RS08405	COG3179	chitinase
RR42_RS08655	COG4695	Portal protein
RR42_RS08705	COG1741	Belongs to the pirin family
RR42_RS08710	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS08715	COG0583	DNA-binding transcription factor activity
RR42_RS08735	COG4279	zinc finger
RR42_RS08740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RR42_RS08755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RR42_RS08760	COG2197	response regulator
RR42_RS08765	COG3850	Histidine kinase
RR42_RS08770	COG2070	2-Nitropropane dioxygenase
RR42_RS08775	COG0826	peptidase U32
RR42_RS08780	COG0826	peptidase U32
RR42_RS08785	COG3154	lipid carrier protein
RR42_RS08795	COG1763	Mo-molybdopterin cofactor biosynthetic process
RR42_RS08805	COG2181	nitrate reductase activity
RR42_RS08810	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RR42_RS08815	COG1140	nitrate reductase beta subunit
RR42_RS08820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RR42_RS08825	COG2223	nitrite transmembrane transporter activity
RR42_RS08835	COG3604	Transcriptional regulator
RR42_RS08840	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
RR42_RS08865	COG2151	metal-sulfur cluster biosynthetic enzyme
RR42_RS08875	COG1959	2 iron, 2 sulfur cluster binding
RR42_RS08890	COG3945	hemerythrin HHE cation binding domain
RR42_RS08900	COG3850	Histidine kinase
RR42_RS08905	COG2197	response regulator
RR42_RS08910	COG2223	nitrite transmembrane transporter activity
RR42_RS08915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RR42_RS08920	COG1140	nitrate reductase beta subunit
RR42_RS08925	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RR42_RS08930	COG2181	nitrate reductase activity
RR42_RS08935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RR42_RS08950	COG0288	reversible hydration of carbon dioxide
RR42_RS08990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RR42_RS09005	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RR42_RS09010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RR42_RS09010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RR42_RS09015	COG0544	peptidyl-prolyl cis-trans isomerase activity
RR42_RS09020	COG0740	serine-type endopeptidase activity
RR42_RS09025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RR42_RS09030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RR42_RS09045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RR42_RS09055	COG4181	ATPase activity
RR42_RS09060	COG0166	Belongs to the GPI family
RR42_RS09075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RR42_RS09125	COG2010	Cytochrome c
RR42_RS09125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RR42_RS09135	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RR42_RS09140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RR42_RS09140	COG0047	phosphoribosylformylglycinamidine synthase activity
RR42_RS09150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RR42_RS09155	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RR42_RS09175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RR42_RS09175	COG1017	nitric oxide dioxygenase activity
RR42_RS09180	COG1959	2 iron, 2 sulfur cluster binding
RR42_RS09185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RR42_RS09210	COG2010	Cytochrome c
RR42_RS09225	COG2814	Major facilitator Superfamily
RR42_RS09230	COG1566	PFAM secretion protein HlyD family protein
RR42_RS09240	COG1846	Transcriptional regulator
RR42_RS09270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RR42_RS09290	COG1773	rubredoxin
RR42_RS09300	COG3384	dioxygenase
RR42_RS09305	COG0583	DNA-binding transcription factor activity
RR42_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS09335	COG0417	DNA replication proofreading
RR42_RS09340	COG1280	lysine exporter protein (LysE YggA)
RR42_RS09355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS09370	COG3246	L-lysine catabolic process to acetate
RR42_RS09375	COG2175	clavaminate synthase activity
RR42_RS09390	COG2909	trisaccharide binding
RR42_RS09395	COG0534	Mate efflux family protein
RR42_RS09405	COG1063	alcohol dehydrogenase
RR42_RS09410	COG3284	Transcriptional regulator
RR42_RS09430	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS09435	COG3663	DNA glycosylase
RR42_RS09445	COG0583	DNA-binding transcription factor activity
RR42_RS09460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RR42_RS09470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RR42_RS09485	COG0765	amino acid transport
RR42_RS09490	COG0765	amino acid transport
RR42_RS09495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS09500	COG1609	Transcriptional regulator
RR42_RS09525	COG2205	protein histidine kinase activity
RR42_RS09540	COG3108	Peptidase M15
RR42_RS09545	COG2989	Protein conserved in bacteria
RR42_RS09550	COG0589	response to stress
RR42_RS09555	COG0589	response to stress
RR42_RS09600	COG2197	response regulator
RR42_RS09610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RR42_RS09625	COG2217	Heavy metal translocating P-type atpase
RR42_RS09640	COG0583	DNA-binding transcription factor activity
RR42_RS09665	COG2831	hemolysin activation secretion protein
RR42_RS09690	COG3188	usher protein
RR42_RS09695	COG3121	Chaperone
RR42_RS09700	COG3539	Fimbrial protein
RR42_RS09710	COG2200	EAL domain
RR42_RS09710	COG2203	Gaf domain
RR42_RS09710	COG2199	diguanylate cyclase activity
RR42_RS09715	COG2197	response regulator
RR42_RS09720	COG0784	Response regulator, receiver
RR42_RS09720	COG2205	protein histidine kinase activity
RR42_RS09730	COG0842	Transport permease protein
RR42_RS09735	COG0842	Transport permease protein
RR42_RS09735	COG1129	ABC transporter
RR42_RS09740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RR42_RS09775	COG0071	Belongs to the small heat shock protein (HSP20) family
RR42_RS09790	COG1136	(ABC) transporter
RR42_RS09835	COG0840	transmembrane signaling receptor activity
RR42_RS09865	COG1649	PFAM Uncharacterised BCR, COG1649
RR42_RS09865	COG0726	polysaccharide deacetylase
RR42_RS09870	COG1215	transferase activity, transferring glycosyl groups
RR42_RS09880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RR42_RS09915	COG2814	Major facilitator Superfamily
RR42_RS09925	COG4691	Plasmid stability protein
RR42_RS09930	COG1487	ribonuclease activity
RR42_RS09940	COG3386	PFAM SMP-30 Gluconolaconase
RR42_RS09955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RR42_RS09990	COG5001	Diguanylate cyclase
RR42_RS09990	COG4251	negative regulation of phosphorylation
RR42_RS09990	COG3706	GGDEF domain
RR42_RS09990	COG2203	Gaf domain
RR42_RS10000	COG0583	DNA-binding transcription factor activity
RR42_RS10010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RR42_RS10015	COG2814	Major facilitator Superfamily
RR42_RS10080	COG2801	Transposase and inactivated derivatives
RR42_RS10085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RR42_RS10100	COG3639	organic phosphonate transmembrane transporter activity
RR42_RS10105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RR42_RS10120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RR42_RS10140	COG0156	8-amino-7-oxononanoate synthase activity
RR42_RS10190	COG2197	response regulator
RR42_RS10210	COG0604	alcohol dehydrogenase
RR42_RS10215	COG1902	pentaerythritol trinitrate reductase activity
RR42_RS10230	COG1960	acyl-CoA dehydrogenase activity
RR42_RS10235	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS10250	COG1024	Enoyl-CoA hydratase
RR42_RS10260	COG0183	Belongs to the thiolase family
RR42_RS10265	COG1250	3-hydroxyacyl-CoA dehydrogenase
RR42_RS10265	COG1024	Enoyl-CoA hydratase
RR42_RS10270	COG1024	Enoyl-CoA hydratase
RR42_RS10280	COG4585	Histidine kinase
RR42_RS10310	COG3246	L-lysine catabolic process to acetate
RR42_RS10315	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS10345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RR42_RS10355	COG1522	sequence-specific DNA binding
RR42_RS10405	COG0583	DNA-binding transcription factor activity
RR42_RS10425	COG2271	Major facilitator Superfamily
RR42_RS10455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RR42_RS10490	COG2916	Histone family protein nucleoid-structuring protein H-NS
RR42_RS10510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RR42_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS10545	COG0604	alcohol dehydrogenase
RR42_RS10565	COG0596	Alpha beta hydrolase
RR42_RS10570	COG1902	pentaerythritol trinitrate reductase activity
RR42_RS10585	COG1309	transcriptional regulator
RR42_RS10600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RR42_RS10605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RR42_RS10605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RR42_RS10610	COG1609	Transcriptional regulator
RR42_RS10615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RR42_RS10630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RR42_RS10640	COG0686	Belongs to the AlaDH PNT family
RR42_RS10650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RR42_RS10655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RR42_RS10660	COG0022	dehydrogenase e1 component
RR42_RS10660	COG0508	dehydrogenase complex catalyzes the overall conversion of
RR42_RS10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RR42_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS10690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RR42_RS10710	COG2031	fatty acid transporter
RR42_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS10730	COG2610	gluconate transmembrane transporter activity
RR42_RS10745	COG0076	glutamate decarboxylase activity
RR42_RS10750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RR42_RS10755	COG3550	peptidyl-serine autophosphorylation
RR42_RS10765	COG0084	hydrolase, TatD family'
RR42_RS10770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RR42_RS10785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RR42_RS10800	COG2072	flavoprotein involved in K transport
RR42_RS10805	COG0601	transmembrane transport
RR42_RS10810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RR42_RS10820	COG4608	Belongs to the ABC transporter superfamily
RR42_RS10825	COG0747	negative chemotaxis
RR42_RS10850	COG1674	ftsk spoiiie
RR42_RS10855	COG2203	Gaf domain
RR42_RS10855	COG3706	GGDEF domain
RR42_RS10855	COG4251	negative regulation of phosphorylation
RR42_RS10855	COG5001	Diguanylate cyclase
RR42_RS10865	COG0583	DNA-binding transcription factor activity
RR42_RS10870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RR42_RS10875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RR42_RS10885	COG0084	hydrolase, TatD family'
RR42_RS10890	COG1247	-acetyltransferase
RR42_RS10900	COG0470	DNA polymerase III
RR42_RS10905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RR42_RS10910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RR42_RS10935	COG0583	DNA-binding transcription factor activity
RR42_RS10955	COG2186	Transcriptional regulator
RR42_RS10960	COG2084	Dehydrogenase
RR42_RS10965	COG3395	kinase activity
RR42_RS10970	COG0235	Class ii aldolase
RR42_RS10975	COG2271	Major facilitator Superfamily
RR42_RS10980	COG3622	Belongs to the hyi family
RR42_RS10985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RR42_RS11005	COG1454	alcohol dehydrogenase
RR42_RS11025	COG1794	racemase activity, acting on amino acids and derivatives
RR42_RS11030	COG0596	Alpha beta hydrolase
RR42_RS11045	COG4221	oxidoreductase activity
RR42_RS11055	COG2130	NADP-dependent
RR42_RS11075	COG1960	acyl-CoA dehydrogenase activity
RR42_RS11085	COG0183	Belongs to the thiolase family
RR42_RS11090	COG1335	isochorismatase
RR42_RS11095	COG1024	Enoyl-CoA hydratase
RR42_RS11095	COG1250	3-hydroxyacyl-CoA dehydrogenase
RR42_RS11100	COG0833	amino acid
RR42_RS11105	COG1301	dicarboxylic acid transport
RR42_RS11115	COG2423	ornithine cyclodeaminase activity
RR42_RS11130	COG0410	ABC transporter
RR42_RS11135	COG0411	ABC transporter
RR42_RS11155	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS11160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RR42_RS11165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RR42_RS11170	COG2917	probably involved in intracellular septation
RR42_RS11180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RR42_RS11190	COG1960	acyl-CoA dehydrogenase activity
RR42_RS11215	COG0747	negative chemotaxis
RR42_RS11220	COG0601	transmembrane transport
RR42_RS11225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RR42_RS11230	COG0444	Belongs to the ABC transporter superfamily
RR42_RS11235	COG4608	Belongs to the ABC transporter superfamily
RR42_RS11240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RR42_RS11255	COG3829	transcription factor binding
RR42_RS11270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RR42_RS11290	COG1309	transcriptional regulator
RR42_RS11295	COG2186	Transcriptional regulator
RR42_RS11300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RR42_RS11305	COG2271	Major facilitator Superfamily
RR42_RS11310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS11320	COG2258	MOSC domain
RR42_RS11340	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS11345	COG1960	acyl-CoA dehydrogenase activity
RR42_RS11350	COG2175	clavaminate synthase activity
RR42_RS11370	COG0488	(ABC) transporter
RR42_RS11375	COG1619	proteins homologs of microcin C7 resistance protein MccF
RR42_RS11385	COG0720	synthase
RR42_RS11390	COG0602	queuosine metabolic process
RR42_RS11395	COG0583	DNA-binding transcription factor activity
RR42_RS11400	COG2814	Major facilitator Superfamily
RR42_RS11420	COG3621	Patatin-like phospholipase
RR42_RS11425	COG2814	Major facilitator Superfamily
RR42_RS11445	COG3284	Transcriptional regulator
RR42_RS11455	COG0596	Alpha beta hydrolase
RR42_RS11460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RR42_RS11465	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
RR42_RS11475	COG0535	radical SAM domain protein
RR42_RS11480	COG4654	Cytochrome c, class I
RR42_RS11490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RR42_RS11520	COG1131	(ABC) transporter
RR42_RS11530	COG2197	response regulator
RR42_RS11535	COG3851	Histidine kinase
RR42_RS11540	COG4206	TonB-dependent receptor
RR42_RS11545	COG1942	4-Oxalocrotonate Tautomerase
RR42_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS11560	COG1944	ATP diphosphatase activity
RR42_RS11610	COG3876	Protein conserved in bacteria
RR42_RS11650	COG3243	poly(R)-hydroxyalkanoic acid synthase
RR42_RS11655	COG0071	Belongs to the small heat shock protein (HSP20) family
RR42_RS11665	COG4876	unkown
RR42_RS11670	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RR42_RS11675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RR42_RS11725	COG1569	PIN domain
RR42_RS11730	COG3311	Transcriptional regulator
RR42_RS11740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RR42_RS11740	COG0519	Catalyzes the synthesis of GMP from XMP
RR42_RS11765	COG2914	Belongs to the UPF0125 (RnfH) family
RR42_RS11770	COG2867	negative regulation of translational initiation
RR42_RS11775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RR42_RS11780	COG0330	HflC and HflK could
RR42_RS11795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RR42_RS11800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RR42_RS11805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RR42_RS11810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RR42_RS11815	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RR42_RS11820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RR42_RS11825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RR42_RS11840	COG0750	zinc metalloprotease
RR42_RS11845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RR42_RS11850	COG0575	Belongs to the CDS family
RR42_RS11855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RR42_RS11860	COG0233	cytoplasmic translational termination
RR42_RS11865	COG0528	UMP kinase activity
RR42_RS11870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RR42_RS11875	COG0052	Belongs to the universal ribosomal protein uS2 family
RR42_RS11880	COG0024	Methionine aminopeptidase
RR42_RS11885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RR42_RS11890	COG1187	pseudouridine synthase activity
RR42_RS11900	COG0242	peptide deformylase activity
RR42_RS11905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RR42_RS11935	COG2171	N-acyltransferase activity
RR42_RS11945	COG1393	Belongs to the ArsC family
RR42_RS11950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RR42_RS11955	COG2890	protein-(glutamine-N5) methyltransferase activity
RR42_RS11980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RR42_RS11985	COG0601	transmembrane transport
RR42_RS11990	COG0747	negative chemotaxis
RR42_RS11995	COG4172	Belongs to the ABC transporter superfamily
RR42_RS12000	COG1446	asparaginase
RR42_RS12010	COG0488	(ABC) transporter
RR42_RS12015	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RR42_RS12020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RR42_RS12035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RR42_RS12040	COG0477	Major facilitator Superfamily
RR42_RS12050	COG1573	uracil-dna glycosylase
RR42_RS12070	COG2814	Major facilitator Superfamily
RR42_RS12105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RR42_RS12120	COG2205	protein histidine kinase activity
RR42_RS12120	COG0784	Response regulator, receiver
RR42_RS12125	COG2197	response regulator
RR42_RS12155	COG3121	Chaperone
RR42_RS12160	COG3188	usher protein
RR42_RS12165	COG3121	Chaperone
RR42_RS12175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RR42_RS12185	COG0583	DNA-binding transcription factor activity
RR42_RS12190	COG0589	response to stress
RR42_RS12195	COG0501	Belongs to the peptidase M48B family
RR42_RS12200	COG2224	Isocitrate lyase
RR42_RS12215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RR42_RS12230	COG2972	Histidine kinase
RR42_RS12245	COG0583	DNA-binding transcription factor activity
RR42_RS12250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RR42_RS12255	COG4208	sulfate ABC transporter
RR42_RS12260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RR42_RS12280	COG1116	anion transmembrane transporter activity
RR42_RS12285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RR42_RS12290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RR42_RS12295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RR42_RS12315	COG0583	DNA-binding transcription factor activity
RR42_RS12325	COG0625	glutathione transferase activity
RR42_RS12340	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS12350	COG2824	Alkylphosphonate utilization operon protein PhnA
RR42_RS12360	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS12370	COG4106	trans-aconitate 2-methyltransferase activity
RR42_RS12400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS12400	COG4191	Histidine kinase
RR42_RS12405	COG3437	response regulator, receiver
RR42_RS12405	COG0784	Response regulator, receiver
RR42_RS12420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RR42_RS12425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RR42_RS12435	COG1615	UPF0182 protein
RR42_RS12455	COG0542	response to heat
RR42_RS12490	COG0411	ABC transporter
RR42_RS12505	COG1309	transcriptional regulator
RR42_RS12510	COG2226	methyltransferase
RR42_RS12510	COG1073	alpha beta
RR42_RS12515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RR42_RS12520	COG0314	molybdopterin synthase activity
RR42_RS12530	COG0303	'Molybdopterin
RR42_RS12545	COG0436	Aminotransferase
RR42_RS12555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RR42_RS12560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RR42_RS12570	COG0791	NLP P60 protein
RR42_RS12575	COG0306	phosphate transporter
RR42_RS12585	COG0305	Participates in initiation and elongation during chromosome replication
RR42_RS12590	COG0359	binds to the 23S rRNA
RR42_RS12595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RR42_RS12605	COG0360	Binds together with S18 to 16S ribosomal RNA
RR42_RS12610	COG0252	asparaginase activity
RR42_RS12615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RR42_RS12665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RR42_RS12675	COG2205	protein histidine kinase activity
RR42_RS12675	COG0784	Response regulator, receiver
RR42_RS12715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RR42_RS12730	COG1538	Outer membrane efflux protein
RR42_RS12760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RR42_RS12765	COG0515	serine threonine protein kinase
RR42_RS12790	COG0431	NADPH-dependent FMN reductase
RR42_RS12795	COG1024	Enoyl-CoA hydratase
RR42_RS12800	COG0840	transmembrane signaling receptor activity
RR42_RS12825	COG1566	PFAM secretion protein HlyD family protein
RR42_RS12830	COG2814	Major facilitator Superfamily
RR42_RS12835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RR42_RS12840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RR42_RS12845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RR42_RS12850	COG0195	Participates in both transcription termination and antitermination
RR42_RS12850	COG2251	uridine kinase activity
RR42_RS12855	COG0779	Required for maturation of 30S ribosomal subunits
RR42_RS12860	COG1187	pseudouridine synthase activity
RR42_RS12865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RR42_RS12875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RR42_RS12890	COG0348	domain, Protein
RR42_RS12910	COG3278	Belongs to the heme-copper respiratory oxidase family
RR42_RS12920	COG2217	Heavy metal translocating P-type atpase
RR42_RS12925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RR42_RS12930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RR42_RS12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
RR42_RS12940	COG0567	Dehydrogenase, E1 component
RR42_RS12950	COG0584	glycerophosphoryl diester phosphodiesterase
RR42_RS12955	COG3842	ATPase activity
RR42_RS12960	COG0395	ABC-type sugar transport system, permease component
RR42_RS12965	COG1175	transmembrane transport
RR42_RS12970	COG1653	transport
RR42_RS12985	COG3852	Histidine kinase
RR42_RS12995	COG0174	glutamine synthetase
RR42_RS13030	COG1643	Atp-dependent helicase
RR42_RS13035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RR42_RS13035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RR42_RS13040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RR42_RS13045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RR42_RS13050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RR42_RS13055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RR42_RS13060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RR42_RS13065	COG0557	exoribonuclease II activity
RR42_RS13075	COG1959	2 iron, 2 sulfur cluster binding
RR42_RS13080	COG2910	NAD(P)H-binding
RR42_RS13085	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RR42_RS13090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RR42_RS13095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RR42_RS13100	COG0330	HflC and HflK could
RR42_RS13105	COG0330	HflC and HflK could
RR42_RS13110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RR42_RS13115	COG1923	regulation of RNA biosynthetic process
RR42_RS13120	COG1160	GTP binding
RR42_RS13130	COG2976	Protein conserved in bacteria
RR42_RS13135	COG0124	histidyl-tRNA synthetase
RR42_RS13140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RR42_RS13155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RR42_RS13160	COG0105	UTP biosynthetic process
RR42_RS13165	COG0670	Belongs to the BI1 family
RR42_RS13170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RR42_RS13195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RR42_RS13200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RR42_RS13205	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS13205	COG3321	synthase
RR42_RS13205	COG0604	alcohol dehydrogenase
RR42_RS13210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS13220	COG0642	Histidine kinase
RR42_RS13235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RR42_RS13245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RR42_RS13255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RR42_RS13260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RR42_RS13270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RR42_RS13275	COG2329	Antibiotic biosynthesis monooxygenase
RR42_RS13280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RR42_RS13285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RR42_RS13295	COG1074	ATP-dependent DNA helicase activity
RR42_RS13315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RR42_RS13325	COG0254	rRNA binding
RR42_RS13335	COG0534	Mate efflux family protein
RR42_RS13355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RR42_RS13360	COG1752	Esterase of the alpha-beta hydrolase superfamily
RR42_RS13365	COG0791	NLP P60 protein
RR42_RS13370	COG4172	Belongs to the ABC transporter superfamily
RR42_RS13375	COG4239	(ABC) transporter, permease
RR42_RS13380	COG4174	ABC transporter (Permease)
RR42_RS13395	COG1073	alpha beta
RR42_RS13415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RR42_RS13420	COG2062	phosphohistidine phosphatase, SixA
RR42_RS13430	COG0248	Ppx GppA phosphatase
RR42_RS13435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RR42_RS13445	COG0745	RESPONSE REGULATOR receiver
RR42_RS13455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RR42_RS13460	COG0581	inorganic phosphate transmembrane transporter activity
RR42_RS13465	COG0573	inorganic phosphate transmembrane transporter activity
RR42_RS13470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RR42_RS13475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RR42_RS13485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RR42_RS13490	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RR42_RS13495	COG1534	Rna-binding protein
RR42_RS13505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RR42_RS13510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RR42_RS13520	COG0505	Belongs to the CarA family
RR42_RS13545	COG1024	Enoyl-CoA hydratase
RR42_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS13560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RR42_RS13565	COG0741	lytic transglycosylase activity
RR42_RS13565	COG1388	LysM domain
RR42_RS13570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RR42_RS13575	COG2226	methyltransferase
RR42_RS13580	COG0328	RNA-DNA hybrid ribonuclease activity
RR42_RS13585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RR42_RS13610	COG1414	Transcriptional regulator
RR42_RS13635	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS13645	COG0477	Major facilitator Superfamily
RR42_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
RR42_RS13665	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RR42_RS13670	COG0028	Belongs to the TPP enzyme family
RR42_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS13680	COG1414	Transcriptional regulator
RR42_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS13710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS13715	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS13720	COG1902	pentaerythritol trinitrate reductase activity
RR42_RS13735	COG0859	PFAM glycosyl transferase family 9
RR42_RS13740	COG1335	isochorismatase
RR42_RS13775	COG0395	ABC-type sugar transport system, permease component
RR42_RS13785	COG3842	ATPase activity
RR42_RS13790	COG3842	ATPase activity
RR42_RS13810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RR42_RS13815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RR42_RS13875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RR42_RS13880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RR42_RS13885	COG0697	spore germination
RR42_RS13910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RR42_RS13915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RR42_RS13940	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RR42_RS13960	COG2855	membrane
RR42_RS13965	COG0583	DNA-binding transcription factor activity
RR42_RS13970	COG4651	solute:proton antiporter activity
RR42_RS13970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RR42_RS13975	COG0840	transmembrane signaling receptor activity
RR42_RS13995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RR42_RS14000	COG0322	excinuclease ABC activity
RR42_RS14010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RR42_RS14020	COG0736	holo-[acyl-carrier-protein] synthase activity
RR42_RS14025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RR42_RS14030	COG1381	Involved in DNA repair and RecF pathway recombination
RR42_RS14035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RR42_RS14040	COG0571	ribonuclease III activity
RR42_RS14050	COG0681	Belongs to the peptidase S26 family
RR42_RS14055	COG0481	GTPase activity
RR42_RS14065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RR42_RS14080	COG1595	DNA-templated transcription, initiation
RR42_RS14090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RR42_RS14095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RR42_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS14110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RR42_RS14115	COG0416	fatty acid biosynthetic process
RR42_RS14120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RR42_RS14125	COG1399	metal-binding, possibly nucleic acid-binding protein
RR42_RS14130	COG0424	maF-like protein
RR42_RS14160	COG1530	ribonuclease E activity
RR42_RS14165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RR42_RS14170	COG0746	molybdenum cofactor guanylyltransferase activity
RR42_RS14200	COG1556	Lactate utilization protein
RR42_RS14205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RR42_RS14215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RR42_RS14220	COG0492	ferredoxin-NADP+ reductase activity
RR42_RS14240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RR42_RS14260	COG0745	RESPONSE REGULATOR receiver
RR42_RS14265	COG2205	protein histidine kinase activity
RR42_RS14275	COG1278	Cold shock
RR42_RS14280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RR42_RS14285	COG1280	lysine exporter protein (LysE YggA)
RR42_RS14295	COG1131	(ABC) transporter
RR42_RS14310	COG0577	efflux transmembrane transporter activity
RR42_RS14310	COG1136	(ABC) transporter
RR42_RS14330	COG1286	toxin biosynthetic process
RR42_RS14340	COG0285	dihydrofolate synthase activity
RR42_RS14345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RR42_RS14350	COG0159	tryptophan synthase activity
RR42_RS14355	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RR42_RS14360	COG0133	tryptophan synthase activity
RR42_RS14365	COG0135	phosphoribosylanthranilate isomerase activity
RR42_RS14370	COG0101	tRNA pseudouridine synthase activity
RR42_RS14380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RR42_RS14385	COG0473	3-isopropylmalate dehydrogenase activity
RR42_RS14390	COG0066	3-isopropylmalate dehydratase activity
RR42_RS14400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RR42_RS14430	COG0372	Belongs to the citrate synthase family
RR42_RS14435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RR42_RS14440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RR42_RS14445	COG1053	succinate dehydrogenase
RR42_RS14450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RR42_RS14460	COG2188	Transcriptional regulator
RR42_RS14465	COG0039	L-malate dehydrogenase activity
RR42_RS14490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RR42_RS14500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RR42_RS14555	COG0326	Molecular chaperone. Has ATPase activity
RR42_RS14560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RR42_RS14570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RR42_RS14580	COG0697	spore germination
RR42_RS14595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RR42_RS14600	COG0625	glutathione transferase activity
RR42_RS14605	COG1280	lysine exporter protein (LysE YggA)
RR42_RS14610	COG1620	l-lactate permease
RR42_RS14615	COG1487	ribonuclease activity
RR42_RS14620	COG2161	toxin-antitoxin pair type II binding
RR42_RS14625	COG0010	Belongs to the arginase family
RR42_RS14650	COG1132	(ABC) transporter
RR42_RS14685	COG0488	(ABC) transporter
RR42_RS14695	COG3135	benzoate transporter
RR42_RS14720	COG0513	Belongs to the DEAD box helicase family
RR42_RS14725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RR42_RS14730	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RR42_RS14735	COG0861	Integral membrane protein TerC family
RR42_RS14740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RR42_RS14750	COG0312	modulator of DNA gyrase
RR42_RS14755	COG3028	Belongs to the UPF0307 family
RR42_RS14760	COG0521	Mo-molybdopterin cofactor biosynthetic process
RR42_RS14770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RR42_RS14775	COG0501	Belongs to the peptidase M48B family
RR42_RS14780	COG1162	GTPase activity
RR42_RS14795	COG1741	Belongs to the pirin family
RR42_RS14800	COG0583	DNA-binding transcription factor activity
RR42_RS14805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RR42_RS14810	COG0513	Belongs to the DEAD box helicase family
RR42_RS14825	COG2268	Band 7 protein
RR42_RS14840	COG1414	Transcriptional regulator
RR42_RS14895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RR42_RS14910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RR42_RS14935	COG0811	peptide transport
RR42_RS14980	COG1610	YqeY-like protein
RR42_RS14985	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RR42_RS14990	COG2081	HI0933 family
RR42_RS14995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RR42_RS15000	COG1469	GTP cyclohydrolase I activity
RR42_RS15005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RR42_RS15010	COG0142	geranyltranstransferase activity
RR42_RS15015	COG1722	exodeoxyribonuclease VII activity
RR42_RS15040	COG0412	Dienelactone hydrolase
RR42_RS15045	COG1252	NADH dehydrogenase
RR42_RS15055	COG1611	Belongs to the LOG family
RR42_RS15065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RR42_RS15075	COG3618	amidohydrolase
RR42_RS15080	COG2188	Transcriptional regulator
RR42_RS15090	COG0210	DNA helicase
RR42_RS15095	COG0525	valine-tRNA ligase activity
RR42_RS15105	COG0425	Belongs to the sulfur carrier protein TusA family
RR42_RS15110	COG2816	NAD+ diphosphatase activity
RR42_RS15120	COG1942	4-Oxalocrotonate Tautomerase
RR42_RS15125	COG0235	Class ii aldolase
RR42_RS15130	COG0477	Major facilitator Superfamily
RR42_RS15140	COG1030	water channel activity
RR42_RS15145	COG0330	HflC and HflK could
RR42_RS15150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RR42_RS15155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RR42_RS15185	COG0583	DNA-binding transcription factor activity
RR42_RS15195	COG0405	Gamma-glutamyltransferase
RR42_RS15210	COG2808	Putative FMN-binding domain
RR42_RS15220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RR42_RS15235	COG2353	YceI-like domain
RR42_RS15250	COG4681	YaeQ
RR42_RS15280	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS15295	COG2703	oxygen carrier activity
RR42_RS15305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RR42_RS15310	COG2982	Protein involved in outer membrane biogenesis
RR42_RS15320	COG0259	pyridoxamine-phosphate oxidase activity
RR42_RS15325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RR42_RS15335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RR42_RS15350	COG1960	acyl-CoA dehydrogenase activity
RR42_RS15365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RR42_RS15375	COG1522	sequence-specific DNA binding
RR42_RS15380	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RR42_RS15390	COG3483	tryptophan 2,3-dioxygenase activity
RR42_RS15400	COG1960	acyl-CoA dehydrogenase activity
RR42_RS15405	COG0450	alkyl hydroperoxide reductase
RR42_RS15425	COG0628	permease
RR42_RS15440	COG2391	methyltransferase activity
RR42_RS15445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RR42_RS15460	COG0823	Involved in the tonB-independent uptake of proteins
RR42_RS15480	COG0824	Thioesterase
RR42_RS15485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RR42_RS15490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RR42_RS15555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RR42_RS15555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RR42_RS15570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RR42_RS15575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RR42_RS15580	COG0436	Aminotransferase
RR42_RS15585	COG0741	lytic transglycosylase activity
RR42_RS15590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RR42_RS15595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RR42_RS15625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RR42_RS15630	COG1968	undecaprenyl-diphosphatase activity
RR42_RS15660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RR42_RS15665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RR42_RS15665	COG0425	Belongs to the sulfur carrier protein TusA family
RR42_RS15670	COG1538	Outer membrane efflux protein
RR42_RS15700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RR42_RS15705	COG0297	glycogen (starch) synthase activity
RR42_RS15715	COG0438	transferase activity, transferring glycosyl groups
RR42_RS15735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RR42_RS15740	COG0110	maltose O-acetyltransferase activity
RR42_RS15755	COG0110	maltose O-acetyltransferase activity
RR42_RS15775	COG2089	acid synthase
RR42_RS15790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RR42_RS15795	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
RR42_RS15805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RR42_RS15810	COG1086	Polysaccharide biosynthesis protein
RR42_RS15815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RR42_RS15845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RR42_RS15855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RR42_RS15860	COG0540	Belongs to the ATCase OTCase family
RR42_RS15865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RR42_RS15870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RR42_RS15875	COG1678	Uncharacterized ACR, COG1678
RR42_RS15880	COG1187	pseudouridine synthase activity
RR42_RS15885	COG0415	Belongs to the DNA photolyase family
RR42_RS15895	COG1587	Uroporphyrinogen-III synthase
RR42_RS15900	COG0181	hydroxymethylbilane synthase activity
RR42_RS15905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RR42_RS15925	COG0165	Argininosuccinate lyase
RR42_RS15945	COG0717	Belongs to the dCTP deaminase family
RR42_RS15950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RR42_RS15955	COG2032	superoxide dismutase activity
RR42_RS15975	COG0437	4 iron, 4 sulfur cluster binding
RR42_RS15980	COG0243	molybdopterin cofactor binding
RR42_RS15980	COG3383	formate dehydrogenase (NAD+) activity
RR42_RS16010	COG0489	protein tyrosine kinase activity
RR42_RS16015	COG3047	cAMP biosynthetic process
RR42_RS16015	COG2885	chlorophyll binding
RR42_RS16020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS16020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS16025	COG0659	secondary active sulfate transmembrane transporter activity
RR42_RS16040	COG0729	surface antigen
RR42_RS16050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RR42_RS16055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RR42_RS16075	COG1492	cobalamin metabolic process
RR42_RS16095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RR42_RS16115	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RR42_RS16120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RR42_RS16130	COG1120	ATPase activity
RR42_RS16135	COG4139	cobalamin transport
RR42_RS16140	COG4206	TonB-dependent receptor
RR42_RS16160	COG0730	response to heat
RR42_RS16170	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS16175	COG1024	Enoyl-CoA hydratase
RR42_RS16190	COG1802	Transcriptional regulator
RR42_RS16195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RR42_RS16200	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RR42_RS16205	COG0583	DNA-binding transcription factor activity
RR42_RS16210	COG0129	dihydroxy-acid dehydratase activity
RR42_RS16225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RR42_RS16235	COG0795	lipopolysaccharide-transporting ATPase activity
RR42_RS16245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RR42_RS16245	COG1648	precorrin-2 dehydrogenase activity
RR42_RS16250	COG2895	sulfate adenylyltransferase (ATP) activity
RR42_RS16255	COG0175	sulfate reduction
RR42_RS16260	COG0175	sulfate reduction
RR42_RS16270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RR42_RS16275	COG0730	response to heat
RR42_RS16280	COG0583	DNA-binding transcription factor activity
RR42_RS16300	COG2885	chlorophyll binding
RR42_RS16300	COG3047	cAMP biosynthetic process
RR42_RS16350	COG3041	Addiction module toxin RelE StbE family
RR42_RS16355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS16360	COG3039	Transposase
RR42_RS16370	COG1126	abc transporter atp-binding protein
RR42_RS16375	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS16385	COG0765	amino acid transport
RR42_RS16390	COG0765	amino acid transport
RR42_RS16395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS16410	COG0583	DNA-binding transcription factor activity
RR42_RS16415	COG1309	transcriptional regulator
RR42_RS16425	COG2226	methyltransferase
RR42_RS16430	COG3039	Transposase
RR42_RS16445	COG1126	abc transporter atp-binding protein
RR42_RS16450	COG0765	amino acid transport
RR42_RS16490	COG0583	DNA-binding transcription factor activity
RR42_RS16500	COG3588	fructose-bisphosphate aldolase
RR42_RS16550	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RR42_RS16560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RR42_RS16570	COG2070	2-Nitropropane dioxygenase
RR42_RS16575	COG1960	acyl-CoA dehydrogenase activity
RR42_RS16585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RR42_RS16595	COG0183	Belongs to the thiolase family
RR42_RS16600	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS16645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RR42_RS16690	COG5507	3-demethylubiquinone-9 3-methyltransferase
RR42_RS16695	COG3795	YCII-related domain
RR42_RS16710	COG0251	oxidation-reduction process
RR42_RS16730	COG3275	phosphorelay sensor kinase activity
RR42_RS16750	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RR42_RS16755	COG0277	FAD linked oxidase domain protein
RR42_RS16760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RR42_RS16765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RR42_RS16770	COG2271	Major facilitator Superfamily
RR42_RS16785	COG1914	H( )-stimulated, divalent metal cation uptake system
RR42_RS16790	COG1024	Enoyl-CoA hydratase
RR42_RS16810	COG2030	dehydratase
RR42_RS16820	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS16825	COG2207	Transcriptional regulator
RR42_RS16835	COG2084	Dehydrogenase
RR42_RS16900	COG0402	S-adenosylhomocysteine deaminase activity
RR42_RS16905	COG1228	amidohydrolase
RR42_RS16915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RR42_RS16920	COG2986	histidine ammonia-lyase
RR42_RS16925	COG2188	Transcriptional regulator
RR42_RS16940	COG2358	TRAP transporter, solute receptor (TAXI family
RR42_RS16955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RR42_RS16965	COG0411	ABC transporter
RR42_RS16985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RR42_RS16990	COG1047	Peptidyl-prolyl cis-trans
RR42_RS16995	COG2003	Belongs to the UPF0758 family
RR42_RS17000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RR42_RS17005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RR42_RS17010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RR42_RS17020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RR42_RS17030	COG0668	transmembrane transport
RR42_RS17045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RR42_RS17045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RR42_RS17050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RR42_RS17055	COG2197	response regulator
RR42_RS17060	COG2205	protein histidine kinase activity
RR42_RS17060	COG2198	Histidine kinase
RR42_RS17060	COG0784	Response regulator, receiver
RR42_RS17065	COG0196	riboflavin kinase activity
RR42_RS17070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RR42_RS17075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RR42_RS17080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RR42_RS17085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RR42_RS17090	COG0756	dUTP diphosphatase activity
RR42_RS17105	COG0542	response to heat
RR42_RS17110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RR42_RS17115	COG1278	Cold shock
RR42_RS17155	COG1666	GTP binding
RR42_RS17160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RR42_RS17165	COG3123	guanosine phosphorylase activity
RR42_RS17170	COG0137	argininosuccinate synthase activity
RR42_RS17175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RR42_RS17185	COG0268	Binds directly to 16S ribosomal RNA
RR42_RS17190	COG0728	peptidoglycan biosynthetic process
RR42_RS17200	COG0586	Pfam SNARE associated Golgi protein
RR42_RS17205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RR42_RS17210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RR42_RS17220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RR42_RS17235	COG0617	tRNA 3'-terminal CCA addition
RR42_RS17250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RR42_RS17255	COG4662	Binding-protein-dependent transport system inner membrane component
RR42_RS17265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RR42_RS17265	COG0512	Glutamine amidotransferase of anthranilate synthase
RR42_RS17270	COG0484	heat shock protein binding
RR42_RS17275	COG0443	Heat shock 70 kDa protein
RR42_RS17280	COG2096	Adenosyltransferase
RR42_RS17285	COG0277	FAD linked oxidase domain protein
RR42_RS17290	COG0583	DNA-binding transcription factor activity
RR42_RS17300	COG0277	FAD linked oxidase domain protein
RR42_RS17305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RR42_RS17310	COG0277	FAD linked oxidase domain protein
RR42_RS17315	COG0247	lactate metabolic process
RR42_RS17320	COG1380	Effector of murein hydrolase LrgA
RR42_RS17325	COG1346	cytolysis
RR42_RS17340	COG0386	Belongs to the glutathione peroxidase family
RR42_RS17365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RR42_RS17370	COG0783	Belongs to the Dps family
RR42_RS17380	COG0753	catalase activity
RR42_RS17390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RR42_RS17395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RR42_RS17400	COG0343	queuine tRNA-ribosyltransferase activity
RR42_RS17405	COG1862	Preprotein translocase
RR42_RS17415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RR42_RS17420	COG2204	response regulator
RR42_RS17430	COG4191	Histidine kinase
RR42_RS17460	COG0625	glutathione transferase activity
RR42_RS17465	COG0482	sulfurtransferase activity
RR42_RS17475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RR42_RS17495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RR42_RS17525	COG1981	membrane
RR42_RS17530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RR42_RS17535	COG1466	dna polymerase III delta subunit
RR42_RS17545	COG0495	leucyl-tRNA aminoacylation
RR42_RS17550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RR42_RS17555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RR42_RS17560	COG0735	belongs to the Fur family
RR42_RS17565	COG0583	DNA-binding transcription factor activity
RR42_RS17570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RR42_RS17575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RR42_RS17580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RR42_RS17590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RR42_RS17605	COG4290	ribonuclease
RR42_RS17615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RR42_RS17620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RR42_RS17625	COG1058	Belongs to the CinA family
RR42_RS17625	COG1546	Belongs to the CinA family
RR42_RS17630	COG0284	orotidine-5'-phosphate decarboxylase activity
RR42_RS17635	COG0598	Magnesium transport protein CorA
RR42_RS17640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RR42_RS17645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RR42_RS17655	COG0557	exoribonuclease II activity
RR42_RS17660	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS17665	COG3161	chorismate lyase activity
RR42_RS17675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RR42_RS17685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RR42_RS17690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RR42_RS17695	COG0511	ligase activity, forming carbon-carbon bonds
RR42_RS17700	COG0439	Biotin carboxylase
RR42_RS17705	COG2264	protein methyltransferase activity
RR42_RS17715	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RR42_RS17720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RR42_RS17765	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS17775	COG3128	pkhd-type hydroxylase
RR42_RS17790	COG2610	gluconate transmembrane transporter activity
RR42_RS17795	COG0656	L-ascorbic acid biosynthetic process
RR42_RS17800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RR42_RS17820	COG2974	May be involved in recombination
RR42_RS17865	COG3023	N-Acetylmuramoyl-L-alanine amidase
RR42_RS17885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RR42_RS17890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RR42_RS17895	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RR42_RS17920	COG0741	lytic transglycosylase activity
RR42_RS17925	COG0442	prolyl-tRNA aminoacylation
RR42_RS17930	COG0494	nUDIX hydrolase
RR42_RS17940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RR42_RS17945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RR42_RS17950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RR42_RS17955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RR42_RS17960	COG0142	geranyltranstransferase activity
RR42_RS17995	COG0237	dephospho-CoA kinase activity
RR42_RS18000	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RR42_RS18005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RR42_RS18010	COG0494	nUDIX hydrolase
RR42_RS18020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RR42_RS18025	COG0653	protein targeting
RR42_RS18030	COG0739	heme binding
RR42_RS18040	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RR42_RS18045	COG0678	peroxiredoxin activity
RR42_RS18060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RR42_RS18065	COG1181	Belongs to the D-alanine--D-alanine ligase family
RR42_RS18070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RR42_RS18075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RR42_RS18085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RR42_RS18090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RR42_RS18095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RR42_RS18100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RR42_RS18110	COG3116	cell division
RR42_RS18115	COG0275	rRNA processing
RR42_RS18120	COG2001	Belongs to the MraZ family
RR42_RS18125	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RR42_RS18130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS18150	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS18160	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS18165	COG4770	biotin carboxylase activity
RR42_RS18180	COG0243	molybdopterin cofactor binding
RR42_RS18190	COG4608	Belongs to the ABC transporter superfamily
RR42_RS18200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RR42_RS18205	COG0601	transmembrane transport
RR42_RS18210	COG0747	negative chemotaxis
RR42_RS18215	COG1473	amidohydrolase
RR42_RS18250	COG1024	Enoyl-CoA hydratase
RR42_RS18255	COG1024	Enoyl-CoA hydratase
RR42_RS18260	COG2050	protein possibly involved in aromatic compounds catabolism
RR42_RS18280	COG2967	ApaG domain
RR42_RS18285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RR42_RS18290	COG0546	phosphoglycolate phosphatase activity
RR42_RS18305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RR42_RS18310	COG0134	indole-3-glycerol-phosphate synthase activity
RR42_RS18320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RR42_RS18325	COG1254	Belongs to the acylphosphatase family
RR42_RS18335	COG1116	anion transmembrane transporter activity
RR42_RS18340	COG1289	transmembrane transporter activity
RR42_RS18350	COG0604	alcohol dehydrogenase
RR42_RS18355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RR42_RS18360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RR42_RS18365	COG0012	GTP binding
RR42_RS18370	COG0582	viral genome integration into host DNA
RR42_RS18455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RR42_RS18465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RR42_RS18470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RR42_RS18480	COG2890	protein-(glutamine-N5) methyltransferase activity
RR42_RS18485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RR42_RS18530	COG0038	chloride channel
RR42_RS18535	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS18565	COG1408	metallophosphoesterase
RR42_RS18575	COG0488	(ABC) transporter
RR42_RS18590	COG3842	ATPase activity
RR42_RS18605	COG3833	ABC-type maltose transport systems, permease component
RR42_RS18615	COG1451	nucleotide metabolic process
RR42_RS18625	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS18650	COG0582	viral genome integration into host DNA
RR42_RS18665	COG1401	restriction endodeoxyribonuclease activity
RR42_RS18675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RR42_RS18710	COG5377	YqaJ viral recombinase family
RR42_RS18760	COG0210	DNA helicase
RR42_RS18805	COG2969	positive regulation of protein catabolic process
RR42_RS18810	COG0625	glutathione transferase activity
RR42_RS18815	COG2857	Cytochrome c1
RR42_RS18820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RR42_RS18825	COG0723	plastoquinol--plastocyanin reductase activity
RR42_RS18830	COG1970	mechanosensitive ion channel activity
RR42_RS18835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RR42_RS18840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RR42_RS18845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS18850	COG0805	protein transport
RR42_RS18855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RR42_RS18860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RR42_RS18875	COG0140	phosphoribosyl-ATP diphosphatase activity
RR42_RS18880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RR42_RS18885	COG0107	imidazoleglycerol-phosphate synthase activity
RR42_RS18890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RR42_RS18895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RR42_RS18900	COG2095	MarC family integral membrane protein
RR42_RS18905	COG0131	Imidazoleglycerol-phosphate dehydratase
RR42_RS18910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RR42_RS18915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RR42_RS18920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RR42_RS18925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RR42_RS18935	COG0842	Transport permease protein
RR42_RS18940	COG1131	(ABC) transporter
RR42_RS18960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RR42_RS18965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RR42_RS18970	COG1127	ABC transporter
RR42_RS18990	COG0069	glutamate synthase activity
RR42_RS18990	COG0067	glutamate synthase
RR42_RS18990	COG0070	glutamate synthase
RR42_RS19000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RR42_RS19005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RR42_RS19010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RR42_RS19045	COG1965	Belongs to the frataxin family
RR42_RS19050	COG0019	diaminopimelate decarboxylase activity
RR42_RS19055	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RR42_RS19060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RR42_RS19080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RR42_RS19085	COG1333	cytochrome c biogenesis protein
RR42_RS19090	COG2863	cytochrome
RR42_RS19095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RR42_RS19105	COG0598	Magnesium transport protein CorA
RR42_RS19110	COG4232	protein-disulfide reductase activity
RR42_RS19115	COG1324	tolerance protein
RR42_RS19120	COG0203	ribosomal protein L17
RR42_RS19125	COG0202	RNA polymerase activity
RR42_RS19130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RR42_RS19135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RR42_RS19140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RR42_RS19145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RR42_RS19150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RR42_RS19155	COG0201	protein transport
RR42_RS19160	COG0200	Binds to the 23S rRNA
RR42_RS19165	COG1841	ribosomal large subunit assembly
RR42_RS19170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RR42_RS19175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RR42_RS19180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RR42_RS19185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RR42_RS19190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RR42_RS19195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RR42_RS19200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RR42_RS19205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RR42_RS19210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RR42_RS19215	COG0255	Belongs to the universal ribosomal protein uL29 family
RR42_RS19220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RR42_RS19225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RR42_RS19230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RR42_RS19235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RR42_RS19240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RR42_RS19245	COG0089	rRNA binding
RR42_RS19250	COG0088	Forms part of the polypeptide exit tunnel
RR42_RS19255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RR42_RS19285	COG0051	transcription antitermination factor activity, RNA binding
RR42_RS19290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RR42_RS19300	COG0049	tRNA binding
RR42_RS19305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RR42_RS19315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RR42_RS19320	COG0085	RNA polymerase activity
RR42_RS19325	COG0222	ribosome binding
RR42_RS19330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RR42_RS19335	COG0081	regulation of translation
RR42_RS19340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RR42_RS19360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RR42_RS19410	COG1802	Transcriptional regulator
RR42_RS19415	COG2715	membrane protein required for spore maturation
RR42_RS19505	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RR42_RS19565	COG1090	epimerase
RR42_RS19580	COG0456	acetyltransferase
RR42_RS19600	COG3384	dioxygenase
RR42_RS19630	COG2818	Glycosylase
RR42_RS19660	COG0737	Belongs to the 5'-nucleotidase family
RR42_RS19665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RR42_RS19670	COG2010	Cytochrome c
RR42_RS19695	COG4654	Cytochrome c, class I
RR42_RS19700	COG4654	Cytochrome c, class I
RR42_RS19705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RR42_RS19710	COG0640	Transcriptional regulator
RR42_RS19715	COG0446	pyridine nucleotide-disulphide oxidoreductase
RR42_RS19725	COG2823	Periplasmic or secreted lipoprotein
RR42_RS19730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RR42_RS19735	COG0792	nuclease activity
RR42_RS19740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RR42_RS19750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RR42_RS19790	COG1301	dicarboxylic acid transport
RR42_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS19805	COG1024	Enoyl-CoA hydratase
RR42_RS19810	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS19825	COG0583	DNA-binding transcription factor activity
RR42_RS19840	COG1473	amidohydrolase
RR42_RS19850	COG3960	tartronate-semialdehyde synthase activity
RR42_RS19855	COG3622	Belongs to the hyi family
RR42_RS19860	COG2084	Dehydrogenase
RR42_RS19870	COG0469	pyruvate kinase activity
RR42_RS19875	COG2321	neutral zinc metallopeptidase
RR42_RS19885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RR42_RS19895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RR42_RS19900	COG0789	Transcriptional regulator
RR42_RS19905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RR42_RS19920	COG3766	membrane
RR42_RS19925	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RR42_RS19940	COG0501	Belongs to the peptidase M48B family
RR42_RS19945	COG4977	sequence-specific DNA binding
RR42_RS19950	COG2814	Major facilitator Superfamily
RR42_RS19955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RR42_RS19955	COG2124	cytochrome p450
RR42_RS19965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RR42_RS19970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RR42_RS19980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RR42_RS19985	COG0745	RESPONSE REGULATOR receiver
RR42_RS20020	COG3245	cytochrome
RR42_RS20025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RR42_RS20055	COG0210	DNA helicase
RR42_RS20060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RR42_RS20065	COG0509	glycine decarboxylation via glycine cleavage system
RR42_RS20070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RR42_RS20070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RR42_RS20075	COG2323	membrane
RR42_RS20080	COG1760	l-serine dehydratase
RR42_RS20090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RR42_RS20100	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RR42_RS20120	COG0683	leucine binding
RR42_RS20125	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RR42_RS20125	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RR42_RS20125	COG0506	proline dehydrogenase activity
RR42_RS20130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RR42_RS20135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RR42_RS20145	COG1832	CoA-binding protein
RR42_RS20155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RR42_RS20160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RR42_RS20165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RR42_RS20170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RR42_RS20175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RR42_RS20180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RR42_RS20190	COG0356	it plays a direct role in the translocation of protons across the membrane
RR42_RS20205	COG1192	Involved in chromosome partitioning
RR42_RS20210	COG0357	Ribosomal RNA small subunit methyltransferase G
RR42_RS20215	COG0445	tRNA wobble uridine modification
RR42_RS20225	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS20230	COG0583	DNA-binding transcription factor activity
RR42_RS20295	COG2267	carboxylic ester hydrolase activity
RR42_RS20305	COG2217	Heavy metal translocating P-type atpase
RR42_RS20315	COG3047	cAMP biosynthetic process
RR42_RS20320	COG2423	ornithine cyclodeaminase activity
RR42_RS20325	COG0667	Aldo Keto reductase
RR42_RS20330	COG0583	DNA-binding transcription factor activity
RR42_RS20345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RR42_RS20360	COG1522	sequence-specific DNA binding
RR42_RS20365	COG3186	Phenylalanine-4-hydroxylase
RR42_RS20370	COG2154	pterin-4-alpha-carbinolamine dehydratase
RR42_RS20380	COG0642	Histidine kinase
RR42_RS20405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RR42_RS20415	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RR42_RS20425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RR42_RS20435	COG2204	response regulator
RR42_RS20435	COG2204	response regulator
RR42_RS20440	COG5000	phosphorelay sensor kinase activity
RR42_RS20455	COG0501	Belongs to the peptidase M48B family
RR42_RS20465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RR42_RS20470	COG0242	peptide deformylase activity
RR42_RS20480	COG0758	DNA mediated transformation
RR42_RS20495	COG0583	DNA-binding transcription factor activity
RR42_RS20510	COG2879	small protein
RR42_RS20515	COG1966	Carbon starvation protein
RR42_RS20530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RR42_RS20540	COG2814	Major facilitator Superfamily
RR42_RS20545	COG2258	MOSC domain
RR42_RS20640	COG1309	transcriptional regulator
RR42_RS20645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RR42_RS20650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RR42_RS20675	COG1522	sequence-specific DNA binding
RR42_RS20700	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RR42_RS20725	COG0508	dehydrogenase complex catalyzes the overall conversion of
RR42_RS20725	COG0596	Alpha beta hydrolase
RR42_RS20735	COG1773	rubredoxin
RR42_RS20745	COG0583	DNA-binding transcription factor activity
RR42_RS20780	COG2755	lipolytic protein G-D-S-L family
RR42_RS20780	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RR42_RS20785	COG2755	lipolytic protein G-D-S-L family
RR42_RS20785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RR42_RS20805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RR42_RS20825	COG3609	addiction module antidote protein, CC2985 family
RR42_RS20830	COG0706	membrane insertase activity
RR42_RS20835	COG0594	ribonuclease P activity
RR42_RS20840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RR42_RS20885	COG1401	restriction endodeoxyribonuclease activity
RR42_RS21510	COG1077	Cell shape determining protein MreB Mrl
RR42_RS21750	COG0789	Transcriptional regulator
RR42_RS22300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RR42_RS22370	COG1012	belongs to the aldehyde dehydrogenase family
RR42_RS22425	COG0840	transmembrane signaling receptor activity
RR42_RS22620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RR42_RS22970	COG1053	succinate dehydrogenase
RR42_RS23110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RR42_RS23330	COG1024	Enoyl-CoA hydratase
RR42_RS23330	COG1250	3-hydroxyacyl-CoA dehydrogenase
RR42_RS23430	COG0473	3-isopropylmalate dehydrogenase activity
RR42_RS23560	COG0006	proline dipeptidase activity
RR42_RS23575	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RR42_RS23820	COG1566	PFAM secretion protein HlyD family protein
RR42_RS23865	COG0045	succinate-CoA ligase (ADP-forming) activity
RR42_RS24010	COG0469	pyruvate kinase activity
RR42_RS24115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RR42_RS24180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RR42_RS24400	COG0435	Glutathione S-transferase
RR42_RS24655	COG2233	PERMEase
RR42_RS25015	COG2271	Major facilitator Superfamily
RR42_RS25095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RR42_RS25225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RR42_RS25755	COG0488	(ABC) transporter
RR42_RS25770	COG1113	amino acid transport
RR42_RS25810	COG3181	Tripartite tricarboxylate transporter family receptor
RR42_RS25880	COG0308	aminopeptidase N
RR42_RS26000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RR42_RS26480	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RR42_RS26485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RR42_RS26920	COG0037	tRNA processing
RR42_RS27115	COG1028	Short-chain dehydrogenase reductase Sdr
RR42_RS27165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS27165	COG0072	phenylalanine-tRNA ligase activity
RR42_RS27995	COG3119	arylsulfatase activity
RR42_RS29185	COG0166	Belongs to the GPI family
RR42_RS29360	COG1017	nitric oxide dioxygenase activity
RR42_RS29360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RR42_RS29890	COG0842	Transport permease protein
RR42_RS29890	COG1129	ABC transporter
RR42_RS30060	COG2814	Major facilitator Superfamily
RR42_RS30460	COG4221	oxidoreductase activity
RR42_RS30815	COG2610	gluconate transmembrane transporter activity
RR42_RS30905	COG0747	negative chemotaxis
RR42_RS31225	COG0318	PFAM AMP-dependent synthetase and ligase
RR42_RS31625	COG1944	ATP diphosphatase activity
RR42_RS32255	COG2224	Isocitrate lyase
RR42_RS32555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RR42_RS32870	COG2217	Heavy metal translocating P-type atpase
RR42_RS33030	COG0557	exoribonuclease II activity
RR42_RS33120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RR42_RS33275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RR42_RS33285	COG0791	NLP P60 protein
RR42_RS33360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RR42_RS33415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RR42_RS33810	COG0322	excinuclease ABC activity
RR42_RS33855	COG0481	GTPase activity
RR42_RS34060	COG1131	(ABC) transporter
RR42_RS34275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RR42_RS34685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RR42_RS34725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RR42_RS34845	COG0525	valine-tRNA ligase activity
RR42_RS35385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RR42_RS35490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RR42_RS35610	COG0165	Argininosuccinate lyase
RR42_RS35735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS35735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS35740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS35740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RR42_RS35815	COG1492	cobalamin metabolic process
RR42_RS35925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RR42_RS36840	COG0137	argininosuccinate synthase activity
RR42_RS37420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RR42_RS37470	COG0142	geranyltranstransferase activity
RR42_RS37525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RR42_RS37555	COG0315	cyclic pyranopterin monophosphate synthase activity
RR42_RS37570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RR42_RS37590	COG2197	response regulator
RR42_RS37595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RR42_RS37750	COG0402	S-adenosylhomocysteine deaminase activity
RR42_RS37765	COG3895	Periplasmic Protein
RR42_RS37780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RR42_RS37810	COG1309	transcriptional regulator
RR42_RS37965	COG2217	Heavy metal translocating P-type atpase