locus-tag	class	description
RMET_RS00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RMET_RS00045	COG0697	spore germination
RMET_RS00055	COG0395	ABC-type sugar transport system, permease component
RMET_RS00060	COG1175	transmembrane transport
RMET_RS00065	COG3842	ATPase activity
RMET_RS00090	COG0513	Belongs to the DEAD box helicase family
RMET_RS00095	COG0517	IMP dehydrogenase activity
RMET_RS00110	COG0426	domain, Protein
RMET_RS00110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RMET_RS00115	COG0179	Fumarylacetoacetate (FAA) hydrolase
RMET_RS00120	COG1473	amidohydrolase
RMET_RS00130	COG2223	nitrite transmembrane transporter activity
RMET_RS00155	COG0745	RESPONSE REGULATOR receiver
RMET_RS00180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RMET_RS00190	COG0850	regulation of cytokinetic process
RMET_RS00195	COG0598	Magnesium transport protein CorA
RMET_RS00205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RMET_RS00210	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RMET_RS00215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RMET_RS00220	COG2205	protein histidine kinase activity
RMET_RS00225	COG0745	RESPONSE REGULATOR receiver
RMET_RS00245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RMET_RS00260	COG0154	amidase activity
RMET_RS00265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RMET_RS00270	COG1077	Cell shape determining protein MreB Mrl
RMET_RS00275	COG1792	Involved in formation and maintenance of cell shape
RMET_RS00280	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RMET_RS00285	COG0768	penicillin binding
RMET_RS00290	COG0772	Belongs to the SEDS family
RMET_RS00300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RMET_RS00305	COG0583	DNA-binding transcription factor activity
RMET_RS00315	COG0321	lipoyl(octanoyl) transferase activity
RMET_RS00320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RMET_RS00325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RMET_RS00330	COG1984	allophanate hydrolase subunit 2
RMET_RS00335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RMET_RS00350	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RMET_RS00375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RMET_RS00385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RMET_RS00395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RMET_RS00435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RMET_RS00455	COG0646	methionine synthase
RMET_RS00455	COG1410	methionine synthase
RMET_RS00465	COG2197	response regulator
RMET_RS00495	COG0018	arginyl-trna synthetase
RMET_RS00505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RMET_RS00510	COG4221	oxidoreductase activity
RMET_RS00530	COG1960	acyl-CoA dehydrogenase activity
RMET_RS00535	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RMET_RS00540	COG0288	reversible hydration of carbon dioxide
RMET_RS00545	COG0183	Belongs to the thiolase family
RMET_RS00555	COG1960	acyl-CoA dehydrogenase activity
RMET_RS00565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RMET_RS00570	COG3012	SEC-C Motif Domain Protein
RMET_RS00580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RMET_RS00590	COG0156	8-amino-7-oxononanoate synthase activity
RMET_RS00595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RMET_RS00600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RMET_RS00605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RMET_RS00620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RMET_RS00625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RMET_RS00630	COG4206	TonB-dependent receptor
RMET_RS00650	COG0523	cobalamin synthesis protein
RMET_RS00660	COG0596	Alpha beta hydrolase
RMET_RS00670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RMET_RS00675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RMET_RS00690	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RMET_RS00700	COG2847	Copper chaperone PCu(A)C
RMET_RS00705	COG0583	DNA-binding transcription factor activity
RMET_RS00715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RMET_RS00730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RMET_RS00745	COG2223	nitrite transmembrane transporter activity
RMET_RS00755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RMET_RS00760	COG0708	Exodeoxyribonuclease III
RMET_RS00765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RMET_RS00775	COG2326	polyphosphate kinase activity
RMET_RS00780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RMET_RS00785	COG1560	Kdo2-lipid A biosynthetic process
RMET_RS00795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RMET_RS00815	COG0840	transmembrane signaling receptor activity
RMET_RS00820	COG1960	acyl-CoA dehydrogenase activity
RMET_RS00825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RMET_RS00840	COG2022	thiamine diphosphate biosynthetic process
RMET_RS00860	COG0351	phosphomethylpyrimidine kinase
RMET_RS00865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RMET_RS00870	COG1950	PFAM Membrane protein of
RMET_RS00875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RMET_RS00880	COG3070	regulator of competence-specific genes
RMET_RS00890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RMET_RS00895	COG0741	lytic transglycosylase activity
RMET_RS00910	COG0617	tRNA 3'-terminal CCA addition
RMET_RS00935	COG0037	tRNA processing
RMET_RS00945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RMET_RS00950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RMET_RS00985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RMET_RS01015	COG0583	DNA-binding transcription factor activity
RMET_RS01025	COG0066	3-isopropylmalate dehydratase activity
RMET_RS01030	COG0596	Alpha beta hydrolase
RMET_RS01040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RMET_RS01045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RMET_RS01055	COG0531	amino acid
RMET_RS01070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RMET_RS01070	COG1703	isobutyryl-CoA mutase activity
RMET_RS01070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RMET_RS01075	COG0537	adenosine 5'-monophosphoramidase activity
RMET_RS01080	COG1250	3-hydroxyacyl-CoA dehydrogenase
RMET_RS01125	COG2832	Protein of unknown function (DUF454)
RMET_RS01135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RMET_RS01140	COG2921	Belongs to the UPF0250 family
RMET_RS01145	COG1686	Belongs to the peptidase S11 family
RMET_RS01150	COG2945	thiolester hydrolase activity
RMET_RS01160	COG1301	dicarboxylic acid transport
RMET_RS01170	COG2204	response regulator
RMET_RS01175	COG2986	histidine ammonia-lyase
RMET_RS01185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RMET_RS01200	COG1280	lysine exporter protein (LysE YggA)
RMET_RS01225	COG0004	ammonium transporteR
RMET_RS01235	COG0189	ligase activity
RMET_RS01245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RMET_RS01250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RMET_RS01265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RMET_RS01270	COG0793	Belongs to the peptidase S41A family
RMET_RS01275	COG0588	phosphoglycerate mutase activity
RMET_RS01280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RMET_RS01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RMET_RS01290	COG3344	reverse transcriptase
RMET_RS01295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RMET_RS01300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RMET_RS01320	COG2226	methyltransferase
RMET_RS01335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RMET_RS01370	COG1612	heme a metabolic process
RMET_RS01375	COG0109	protoheme IX farnesyltransferase activity
RMET_RS01380	COG1999	signal sequence binding
RMET_RS01385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RMET_RS01390	COG1741	Belongs to the pirin family
RMET_RS01395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RMET_RS01400	COG1116	anion transmembrane transporter activity
RMET_RS01405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RMET_RS01410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RMET_RS01425	COG0625	glutathione transferase activity
RMET_RS01435	COG0612	Peptidase, M16
RMET_RS01440	COG0612	Peptidase, M16
RMET_RS01445	COG0742	ribosomal rna small subunit methyltransferase
RMET_RS01450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RMET_RS01455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RMET_RS01460	COG0193	aminoacyl-tRNA hydrolase activity
RMET_RS01465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RMET_RS01470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RMET_RS01480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RMET_RS01485	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RMET_RS01495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RMET_RS01505	COG1194	a g-specific adenine glycosylase
RMET_RS01515	COG1660	Displays ATPase and GTPase activities
RMET_RS01525	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RMET_RS01535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RMET_RS01540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RMET_RS01545	COG1137	ATPase activity
RMET_RS01575	COG0693	protein deglycase activity
RMET_RS01580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RMET_RS01585	COG1283	sodium-dependent phosphate transmembrane transporter activity
RMET_RS01595	COG2814	Major facilitator Superfamily
RMET_RS01600	COG0629	single-stranded DNA binding
RMET_RS01665	COG0431	NADPH-dependent FMN reductase
RMET_RS01675	COG0798	PFAM Bile acid sodium symporter
RMET_RS01700	COG0739	heme binding
RMET_RS01700	COG1196	nuclear chromosome segregation
RMET_RS01700	COG0741	lytic transglycosylase activity
RMET_RS01735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RMET_RS01745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RMET_RS01750	COG3246	L-lysine catabolic process to acetate
RMET_RS01755	COG0436	Aminotransferase
RMET_RS01765	COG0842	Transport permease protein
RMET_RS01770	COG1131	(ABC) transporter
RMET_RS01790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RMET_RS01790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RMET_RS01795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RMET_RS01800	COG1877	trehalose-phosphatase activity
RMET_RS01810	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RMET_RS01820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RMET_RS01855	COG1238	metal cluster binding
RMET_RS01870	COG4178	(ABC) transporter
RMET_RS01880	COG2226	methyltransferase
RMET_RS01895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RMET_RS01915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RMET_RS01925	COG0494	nUDIX hydrolase
RMET_RS01935	COG1763	Mo-molybdopterin cofactor biosynthetic process
RMET_RS01950	COG1960	acyl-CoA dehydrogenase activity
RMET_RS01955	COG1024	Enoyl-CoA hydratase
RMET_RS01955	COG1250	3-hydroxyacyl-CoA dehydrogenase
RMET_RS01960	COG0183	Belongs to the thiolase family
RMET_RS01970	COG1024	Enoyl-CoA hydratase
RMET_RS01975	COG1607	acyl-coa hydrolase
RMET_RS01980	COG5265	(ABC) transporter
RMET_RS01990	COG1116	anion transmembrane transporter activity
RMET_RS01995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RMET_RS02000	COG1522	sequence-specific DNA binding
RMET_RS02015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RMET_RS02025	COG0765	amino acid transport
RMET_RS02030	COG0765	amino acid transport
RMET_RS02035	COG1126	abc transporter atp-binding protein
RMET_RS02040	COG0121	glutamine amidotransferase
RMET_RS02045	COG0473	3-isopropylmalate dehydrogenase activity
RMET_RS02055	COG0418	dihydroorotase activity
RMET_RS02065	COG1765	OsmC-like protein
RMET_RS02070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RMET_RS02075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RMET_RS02090	COG0316	Belongs to the HesB IscA family
RMET_RS02095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RMET_RS02105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RMET_RS02110	COG1490	D-aminoacyl-tRNA deacylase activity
RMET_RS02115	COG1881	PFAM PEBP family protein
RMET_RS02135	COG2255	four-way junction helicase activity
RMET_RS02140	COG0632	four-way junction helicase activity
RMET_RS02145	COG0584	glycerophosphoryl diester phosphodiesterase
RMET_RS02150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RMET_RS02155	COG0138	bifunctional purine biosynthesis protein purh
RMET_RS02160	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RMET_RS02170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RMET_RS02180	COG0006	proline dipeptidase activity
RMET_RS02200	COG3178	'Phosphotransferase
RMET_RS02205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RMET_RS02210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RMET_RS02215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RMET_RS02220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RMET_RS02235	COG0346	lactoylglutathione lyase activity
RMET_RS02250	COG0204	Acyl-transferase
RMET_RS02255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RMET_RS02260	COG0751	glycine-tRNA ligase activity
RMET_RS02270	COG0752	glycyl-tRNA synthetase alpha subunit
RMET_RS02275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RMET_RS02285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RMET_RS02290	COG1702	phosphate starvation-inducible protein PhoH
RMET_RS02295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RMET_RS02305	COG0038	chloride channel
RMET_RS02310	COG0513	Belongs to the DEAD box helicase family
RMET_RS02315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RMET_RS02330	COG0076	glutamate decarboxylase activity
RMET_RS02350	COG0642	Histidine kinase
RMET_RS02360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RMET_RS02365	COG2137	regulation of response to DNA damage stimulus
RMET_RS02375	COG0045	succinate-CoA ligase (ADP-forming) activity
RMET_RS02380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RMET_RS02385	COG0861	Integral membrane protein TerC family
RMET_RS02420	COG0315	cyclic pyranopterin monophosphate synthase activity
RMET_RS02430	COG3328	transposase activity
RMET_RS02460	COG0315	cyclic pyranopterin monophosphate synthase activity
RMET_RS02465	COG4783	chaperone-mediated protein folding
RMET_RS02475	COG0429	hydrolase of the alpha beta-hydrolase fold
RMET_RS02485	COG0859	PFAM glycosyl transferase family 9
RMET_RS02500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RMET_RS02505	COG0154	amidase activity
RMET_RS02510	COG2814	Major facilitator Superfamily
RMET_RS02535	COG0126	phosphoglycerate kinase activity
RMET_RS02550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RMET_RS02555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RMET_RS02560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RMET_RS02565	COG0009	L-threonylcarbamoyladenylate synthase
RMET_RS02570	COG2027	D-alanyl-D-alanine carboxypeptidase
RMET_RS02590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RMET_RS02595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RMET_RS02600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RMET_RS02615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RMET_RS02625	COG4974	Belongs to the 'phage' integrase family
RMET_RS02650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RMET_RS02655	COG0802	atpase or kinase
RMET_RS02660	COG0860	N-Acetylmuramoyl-L-alanine amidase
RMET_RS02670	COG0583	DNA-binding transcription factor activity
RMET_RS02675	COG2226	methyltransferase
RMET_RS02690	COG0563	adenylate kinase activity
RMET_RS02695	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RMET_RS02700	COG2835	tetraacyldisaccharide 4'-kinase activity
RMET_RS02705	COG1663	tetraacyldisaccharide 4'-kinase activity
RMET_RS02710	COG0848	biopolymer transport protein
RMET_RS02715	COG0811	peptide transport
RMET_RS02720	COG1570	exodeoxyribonuclease VII activity
RMET_RS02735	COG2271	Major facilitator Superfamily
RMET_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS02765	COG2610	gluconate transmembrane transporter activity
RMET_RS02770	COG3604	Transcriptional regulator
RMET_RS02790	COG1910	domain protein
RMET_RS02805	COG3383	formate dehydrogenase (NAD+) activity
RMET_RS02810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RMET_RS02820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RMET_RS02825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RMET_RS02830	COG0471	metal ion transport
RMET_RS02835	COG2365	Tyrosine phosphatase family
RMET_RS02840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RMET_RS02855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RMET_RS02875	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RMET_RS02880	COG4149	molybdate abc transporter
RMET_RS02905	COG3121	Chaperone
RMET_RS02925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RMET_RS02925	COG3008	intermembrane lipid transfer
RMET_RS02930	COG2995	paraquat-inducible protein a
RMET_RS02940	COG0628	permease
RMET_RS02945	COG0517	IMP dehydrogenase activity
RMET_RS02945	COG0516	GMP reductase activity
RMET_RS02960	COG2423	ornithine cyclodeaminase activity
RMET_RS02980	COG1301	dicarboxylic acid transport
RMET_RS02985	COG3447	MASE1 domain protein
RMET_RS02985	COG5002	protein histidine kinase activity
RMET_RS02985	COG5001	Diguanylate cyclase
RMET_RS03015	COG1595	DNA-templated transcription, initiation
RMET_RS03035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RMET_RS03040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RMET_RS03060	COG1752	Esterase of the alpha-beta hydrolase superfamily
RMET_RS03080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RMET_RS03085	COG0318	PFAM AMP-dependent synthetase and ligase
RMET_RS03100	COG3468	outer membrane autotransporter barrel domain protein
RMET_RS03105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RMET_RS03110	COG0459	protein refolding
RMET_RS03135	COG2885	chlorophyll binding
RMET_RS03265	COG4964	Belongs to the GSP D family
RMET_RS03310	COG0463	Glycosyl transferase, family 2
RMET_RS03330	COG0583	DNA-binding transcription factor activity
RMET_RS03360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RMET_RS03365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RMET_RS03370	COG1773	rubredoxin
RMET_RS03390	COG0840	transmembrane signaling receptor activity
RMET_RS03395	COG0643	Histidine kinase
RMET_RS03395	COG2198	Histidine kinase
RMET_RS03400	COG2271	Major facilitator Superfamily
RMET_RS03415	COG1012	belongs to the aldehyde dehydrogenase family
RMET_RS03420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RMET_RS03435	COG0347	Belongs to the P(II) protein family
RMET_RS03440	COG2860	membrane
RMET_RS03445	COG2840	Smr protein MutS2
RMET_RS03450	COG0492	ferredoxin-NADP+ reductase activity
RMET_RS03455	COG1674	ftsk spoiiie
RMET_RS03460	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RMET_RS03475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RMET_RS03480	COG0765	amino acid transport
RMET_RS03485	COG0765	amino acid transport
RMET_RS03495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RMET_RS03500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RMET_RS03515	COG1253	flavin adenine dinucleotide binding
RMET_RS03520	COG0583	DNA-binding transcription factor activity
RMET_RS03525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RMET_RS03530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RMET_RS03540	COG0189	ligase activity
RMET_RS03540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RMET_RS03545	COG0189	ligase activity
RMET_RS03545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RMET_RS03550	COG1132	(ABC) transporter
RMET_RS03570	COG0546	phosphoglycolate phosphatase activity
RMET_RS03575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RMET_RS03595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RMET_RS03605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RMET_RS03610	COG0287	Prephenate dehydrogenase
RMET_RS03615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RMET_RS03625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RMET_RS03635	COG0776	regulation of translation
RMET_RS03645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RMET_RS03655	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RMET_RS03660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RMET_RS03670	COG2233	PERMEase
RMET_RS03680	COG2951	lytic endotransglycosylase activity
RMET_RS03685	COG0123	including yeast histone deacetylase and acetoin utilization protein
RMET_RS03690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RMET_RS03695	COG2011	ABC-type metal ion transport system permease component
RMET_RS03715	COG1960	acyl-CoA dehydrogenase activity
RMET_RS03720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RMET_RS03735	COG0583	DNA-binding transcription factor activity
RMET_RS03755	COG0228	four-way junction DNA binding
RMET_RS03760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RMET_RS03765	COG0336	Belongs to the RNA methyltransferase TrmD family
RMET_RS03770	COG0335	large ribosomal subunit rRNA binding
RMET_RS03780	COG1054	Belongs to the UPF0176 family
RMET_RS03800	COG1132	(ABC) transporter
RMET_RS03815	COG3454	Phosphonate metabolism
RMET_RS03820	COG4778	phosphonate C-P lyase system protein PhnL
RMET_RS03825	COG4107	phosphonate C-P lyase system protein PhnK
RMET_RS03830	COG3627	carbon phosphorus lyase activity
RMET_RS03835	COG3626	phosphonate metabolism
RMET_RS03845	COG3624	Phosphonate C-P lyase system protein PhnG
RMET_RS03850	COG2188	Transcriptional regulator
RMET_RS03855	COG3454	Phosphonate metabolism
RMET_RS03860	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RMET_RS03865	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RMET_RS03880	COG3639	organic phosphonate transmembrane transporter activity
RMET_RS03885	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RMET_RS03890	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RMET_RS03895	COG2271	Major facilitator Superfamily
RMET_RS03900	COG2814	Major facilitator Superfamily
RMET_RS03905	COG1530	ribonuclease E activity
RMET_RS03910	COG0424	maF-like protein
RMET_RS03915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RMET_RS03920	COG0799	negative regulation of ribosome biogenesis
RMET_RS03930	COG0408	coproporphyrinogen oxidase activity
RMET_RS03935	COG0151	Belongs to the GarS family
RMET_RS03940	COG0217	transcriptional regulatory protein
RMET_RS03945	COG0433	COG0433 Predicted ATPase
RMET_RS03950	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RMET_RS03960	COG0697	spore germination
RMET_RS03965	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS03970	COG1803	Methylglyoxal synthase
RMET_RS03990	COG4603	Belongs to the binding-protein-dependent transport system permease family
RMET_RS03995	COG3845	ABC transporter
RMET_RS04000	COG1741	Belongs to the pirin family
RMET_RS04040	COG0477	Major facilitator Superfamily
RMET_RS04045	COG0235	Class ii aldolase
RMET_RS04050	COG1942	4-Oxalocrotonate Tautomerase
RMET_RS04065	COG0425	Belongs to the sulfur carrier protein TusA family
RMET_RS04075	COG4681	YaeQ
RMET_RS04100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RMET_RS04145	COG3263	regulation of cellular component size
RMET_RS04160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS04165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RMET_RS04175	COG2186	Transcriptional regulator
RMET_RS04185	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS04195	COG4774	siderophore transport
RMET_RS04200	COG3128	pkhd-type hydroxylase
RMET_RS04215	COG1024	Enoyl-CoA hydratase
RMET_RS04235	COG1960	acyl-CoA dehydrogenase activity
RMET_RS04270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RMET_RS04275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RMET_RS04280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RMET_RS04290	COG0515	serine threonine protein kinase
RMET_RS04295	COG1561	YicC-like family, N-terminal region
RMET_RS04300	COG0194	GDP metabolic process
RMET_RS04305	COG1758	RNA polymerase activity
RMET_RS04310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RMET_RS04370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RMET_RS04380	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RMET_RS04410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RMET_RS04415	COG0308	aminopeptidase N
RMET_RS04425	COG0280	phosphate acetyltransferase
RMET_RS04425	COG0281	malic enzyme
RMET_RS04440	COG3648	Uricase
RMET_RS04440	COG3195	allantoin biosynthetic process
RMET_RS04450	COG2233	PERMEase
RMET_RS04460	COG2351	hydroxyisourate hydrolase activity
RMET_RS04470	COG2119	membrane
RMET_RS04480	COG0402	S-adenosylhomocysteine deaminase activity
RMET_RS04485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RMET_RS04495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RMET_RS04525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RMET_RS04555	COG0438	transferase activity, transferring glycosyl groups
RMET_RS04590	COG0028	Belongs to the TPP enzyme family
RMET_RS04595	COG0440	acetolactate synthase activity
RMET_RS04600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RMET_RS04605	COG0688	phosphatidylethanolamine metabolic process
RMET_RS04610	COG1183	phosphatidylcholine synthase activity
RMET_RS04615	COG1652	LysM domain
RMET_RS04620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RMET_RS04630	COG0683	leucine binding
RMET_RS04635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RMET_RS04640	COG1185	polyribonucleotide nucleotidyltransferase activity
RMET_RS04645	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS04645	COG0604	alcohol dehydrogenase
RMET_RS04645	COG3321	synthase
RMET_RS04650	COG0149	triose-phosphate isomerase activity
RMET_RS04665	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RMET_RS04670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RMET_RS04675	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RMET_RS04680	COG0649	NAD binding
RMET_RS04695	COG1034	ATP synthesis coupled electron transport
RMET_RS04700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RMET_RS04705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RMET_RS04715	COG0713	ATP synthesis coupled electron transport
RMET_RS04730	COG1007	ATP synthesis coupled electron transport
RMET_RS04750	COG1960	acyl-CoA dehydrogenase activity
RMET_RS04755	COG1960	acyl-CoA dehydrogenase activity
RMET_RS04770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RMET_RS04785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RMET_RS04815	COG0829	nickel cation binding
RMET_RS04820	COG0831	urea catabolic process
RMET_RS04830	COG0832	Belongs to the urease beta subunit family
RMET_RS04835	COG0804	urea catabolic process
RMET_RS04840	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RMET_RS04845	COG0830	nickel cation binding
RMET_RS04850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RMET_RS04865	COG0625	glutathione transferase activity
RMET_RS04870	COG1960	acyl-CoA dehydrogenase activity
RMET_RS04880	COG0405	Gamma-glutamyltransferase
RMET_RS04885	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS04895	COG1024	Enoyl-CoA hydratase
RMET_RS04900	COG1250	3-hydroxyacyl-CoA dehydrogenase
RMET_RS04905	COG0625	glutathione transferase activity
RMET_RS04910	COG0436	Aminotransferase
RMET_RS04920	COG3022	response to hydroperoxide
RMET_RS04925	COG2866	Carboxypeptidase
RMET_RS04940	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS04945	COG0583	DNA-binding transcription factor activity
RMET_RS04960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RMET_RS04975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RMET_RS04985	COG0312	modulator of DNA gyrase
RMET_RS04990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RMET_RS05000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RMET_RS05010	COG1404	Belongs to the peptidase S8 family
RMET_RS05020	COG0497	DNA recombination
RMET_RS05025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RMET_RS05030	COG1420	regulation of RNA biosynthetic process
RMET_RS05035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RMET_RS05050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RMET_RS05075	COG0778	Nitroreductase
RMET_RS05100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RMET_RS05105	COG2878	Part of a membrane complex involved in electron transport
RMET_RS05110	COG1309	transcriptional regulator
RMET_RS05125	COG0556	nucleotide-excision repair
RMET_RS05140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RMET_RS05155	COG1104	cysteine desulfurase activity
RMET_RS05160	COG0822	iron-sulfur transferase activity
RMET_RS05165	COG0316	Belongs to the HesB IscA family
RMET_RS05170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RMET_RS05175	COG0443	Heat shock 70 kDa protein
RMET_RS05200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RMET_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS05210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RMET_RS05220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RMET_RS05235	COG1136	(ABC) transporter
RMET_RS05240	COG0084	hydrolase, TatD family'
RMET_RS05250	COG0837	glucose binding
RMET_RS05250	COG1737	Transcriptional regulator
RMET_RS05260	COG3265	gluconokinase activity
RMET_RS05265	COG2308	Evidence 4 Homologs of previously reported genes of
RMET_RS05285	COG2267	carboxylic ester hydrolase activity
RMET_RS05290	COG0504	CTP synthase activity
RMET_RS05295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RMET_RS05305	COG0148	phosphopyruvate hydratase activity
RMET_RS05310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RMET_RS05320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RMET_RS05330	COG2833	Protein of unknown function (DUF455)
RMET_RS05335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RMET_RS05340	COG2267	carboxylic ester hydrolase activity
RMET_RS05345	COG0492	ferredoxin-NADP+ reductase activity
RMET_RS05350	COG0613	PHP domain protein
RMET_RS05355	COG0009	L-threonylcarbamoyladenylate synthase
RMET_RS05360	COG1994	Peptidase M50
RMET_RS05365	COG0500	methyltransferase
RMET_RS05370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RMET_RS05375	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RMET_RS05380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RMET_RS05390	COG2850	peptidyl-arginine hydroxylation
RMET_RS05405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RMET_RS05420	COG0483	inositol monophosphate 1-phosphatase activity
RMET_RS05430	COG1045	serine acetyltransferase
RMET_RS05435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RMET_RS05445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RMET_RS05455	COG0215	cysteine-tRNA ligase activity
RMET_RS05460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RMET_RS05465	COG0825	malonyl-CoA metabolic process
RMET_RS05470	COG0037	tRNA processing
RMET_RS05485	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RMET_RS05495	COG0471	metal ion transport
RMET_RS05525	COG0523	cobalamin synthesis protein
RMET_RS05530	COG1469	GTP cyclohydrolase I activity
RMET_RS05535	COG0215	cysteine-tRNA ligase activity
RMET_RS05585	COG0019	diaminopimelate decarboxylase activity
RMET_RS05595	COG4264	IucA IucC family
RMET_RS05600	COG4264	IucA IucC family
RMET_RS05605	COG2814	Major facilitator Superfamily
RMET_RS05610	COG4264	IucA IucC family
RMET_RS05615	COG2423	ornithine cyclodeaminase activity
RMET_RS05620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RMET_RS05640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RMET_RS05645	COG1301	dicarboxylic acid transport
RMET_RS05655	COG0243	molybdopterin cofactor binding
RMET_RS05660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RMET_RS05665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RMET_RS05675	COG0277	FAD linked oxidase domain protein
RMET_RS05690	COG1295	ribonuclease BN
RMET_RS05700	COG2267	carboxylic ester hydrolase activity
RMET_RS05725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RMET_RS05730	COG2814	Major facilitator Superfamily
RMET_RS05735	COG0579	oxidoreductase
RMET_RS05740	COG2186	Transcriptional regulator
RMET_RS05750	COG2010	Cytochrome c
RMET_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS05785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RMET_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS05825	COG0251	oxidation-reduction process
RMET_RS05830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RMET_RS05840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RMET_RS05845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RMET_RS05850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RMET_RS05855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RMET_RS05860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RMET_RS05865	COG0072	phenylalanine-tRNA ligase activity
RMET_RS05865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RMET_RS05870	COG0776	regulation of translation
RMET_RS05890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RMET_RS05910	COG0745	RESPONSE REGULATOR receiver
RMET_RS05915	COG2205	protein histidine kinase activity
RMET_RS05925	COG0148	phosphopyruvate hydratase activity
RMET_RS05950	COG2902	Dehydrogenase
RMET_RS06010	COG0339	signal peptide processing
RMET_RS06015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RMET_RS06025	COG4566	intracellular signal transduction
RMET_RS06035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RMET_RS06040	COG0508	dehydrogenase complex catalyzes the overall conversion of
RMET_RS06050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RMET_RS06060	COG0123	including yeast histone deacetylase and acetoin utilization protein
RMET_RS06065	COG0824	Thioesterase
RMET_RS06080	COG1414	Transcriptional regulator
RMET_RS06115	COG0667	Aldo Keto reductase
RMET_RS06120	COG0167	dihydroorotate dehydrogenase activity
RMET_RS06125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RMET_RS06135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RMET_RS06205	COG0411	ABC transporter
RMET_RS06215	COG3158	transport of potassium into the cell
RMET_RS06220	COG2183	response to ionizing radiation
RMET_RS06235	COG1199	ATP-dependent helicase activity
RMET_RS06245	COG4804	nuclease activity
RMET_RS06250	COG2003	Belongs to the UPF0758 family
RMET_RS06255	COG4974	Belongs to the 'phage' integrase family
RMET_RS06260	COG0582	viral genome integration into host DNA
RMET_RS06265	COG0582	viral genome integration into host DNA
RMET_RS06280	COG1475	DNA binding
RMET_RS06290	COG5489	Protein of unknown function (DUF736)
RMET_RS06325	COG1192	Involved in chromosome partitioning
RMET_RS06360	COG3328	transposase activity
RMET_RS06375	COG1611	Belongs to the LOG family
RMET_RS06380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RMET_RS06395	COG0842	Transport permease protein
RMET_RS06400	COG0842	Transport permease protein
RMET_RS06410	COG4974	Belongs to the 'phage' integrase family
RMET_RS06415	COG0582	viral genome integration into host DNA
RMET_RS06425	COG4372	Transposase
RMET_RS06430	COG3436	PFAM IS66 Orf2 family protein
RMET_RS06440	COG1131	(ABC) transporter
RMET_RS06450	COG2801	Transposase and inactivated derivatives
RMET_RS06455	COG0309	Hydrogenase expression formation protein (HypE)
RMET_RS06460	COG0409	Hydrogenase expression formation protein
RMET_RS06465	COG0298	carbon dioxide binding
RMET_RS06470	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RMET_RS06475	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RMET_RS06480	COG0375	protein maturation
RMET_RS06485	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RMET_RS06495	COG1773	rubredoxin
RMET_RS06500	COG1773	rubredoxin
RMET_RS06505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RMET_RS06510	COG0298	carbon dioxide binding
RMET_RS06515	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RMET_RS06525	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RMET_RS06540	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RMET_RS06565	COG2963	transposase activity
RMET_RS06655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RMET_RS06660	COG4569	acetaldehyde dehydrogenase (acetylating) activity
RMET_RS06685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RMET_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS06730	COG0589	response to stress
RMET_RS06740	COG0583	DNA-binding transcription factor activity
RMET_RS06760	COG4962	Type ii secretion system protein e
RMET_RS06765	COG3838	Conjugal transfer protein Trbc
RMET_RS06775	COG3451	type IV secretory pathway VirB4
RMET_RS06790	COG3846	protein secretion by the type IV secretion system
RMET_RS06820	COG0564	pseudouridine synthase activity
RMET_RS06835	COG3243	poly(R)-hydroxyalkanoic acid synthase
RMET_RS06840	COG0183	Belongs to the thiolase family
RMET_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS06860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RMET_RS06865	COG0183	Belongs to the thiolase family
RMET_RS06895	COG0560	Phosphoserine phosphatase
RMET_RS06900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RMET_RS06905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RMET_RS06910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RMET_RS06915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RMET_RS06920	COG1116	anion transmembrane transporter activity
RMET_RS06935	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RMET_RS06940	COG4208	sulfate ABC transporter
RMET_RS06945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RMET_RS06950	COG0583	DNA-binding transcription factor activity
RMET_RS06955	COG2972	Histidine kinase
RMET_RS06965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RMET_RS06975	COG2267	carboxylic ester hydrolase activity
RMET_RS06980	COG2224	Isocitrate lyase
RMET_RS06990	COG0589	response to stress
RMET_RS06995	COG0583	DNA-binding transcription factor activity
RMET_RS07005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RMET_RS07020	COG2814	Major facilitator Superfamily
RMET_RS07040	COG1573	uracil-dna glycosylase
RMET_RS07050	COG0477	Major facilitator Superfamily
RMET_RS07055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RMET_RS07070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RMET_RS07075	COG0488	(ABC) transporter
RMET_RS07090	COG4172	Belongs to the ABC transporter superfamily
RMET_RS07095	COG0747	negative chemotaxis
RMET_RS07105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RMET_RS07140	COG2010	Cytochrome c
RMET_RS07150	COG2890	protein-(glutamine-N5) methyltransferase activity
RMET_RS07155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RMET_RS07160	COG1393	Belongs to the ArsC family
RMET_RS07170	COG2171	N-acyltransferase activity
RMET_RS07195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RMET_RS07200	COG0242	peptide deformylase activity
RMET_RS07205	COG0477	Major facilitator Superfamily
RMET_RS07215	COG1187	pseudouridine synthase activity
RMET_RS07220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RMET_RS07225	COG0024	Methionine aminopeptidase
RMET_RS07230	COG0052	Belongs to the universal ribosomal protein uS2 family
RMET_RS07235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RMET_RS07240	COG0528	UMP kinase activity
RMET_RS07245	COG0233	cytoplasmic translational termination
RMET_RS07250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RMET_RS07255	COG0575	Belongs to the CDS family
RMET_RS07260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RMET_RS07265	COG0750	zinc metalloprotease
RMET_RS07280	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RMET_RS07285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RMET_RS07290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RMET_RS07295	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RMET_RS07300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RMET_RS07305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RMET_RS07315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RMET_RS07330	COG0330	HflC and HflK could
RMET_RS07335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RMET_RS07340	COG2867	negative regulation of translational initiation
RMET_RS07345	COG2914	Belongs to the UPF0125 (RnfH) family
RMET_RS07370	COG0519	Catalyzes the synthesis of GMP from XMP
RMET_RS07370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RMET_RS07375	COG0582	viral genome integration into host DNA
RMET_RS07395	COG0084	hydrolase, TatD family'
RMET_RS07445	COG1475	DNA binding
RMET_RS07455	COG5489	Protein of unknown function (DUF736)
RMET_RS07460	COG1396	sequence-specific DNA binding
RMET_RS07485	COG1192	Involved in chromosome partitioning
RMET_RS07500	COG4959	Type IV secretory pathway protease TraF
RMET_RS07520	COG0191	fructose-bisphosphate aldolase activity
RMET_RS07530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RMET_RS07555	COG4451	ribulose bisphosphate carboxylase, small
RMET_RS07560	COG1850	ribulose-bisphosphate carboxylase activity
RMET_RS07565	COG0583	DNA-binding transcription factor activity
RMET_RS07570	COG3328	transposase activity
RMET_RS07585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RMET_RS07590	COG0583	DNA-binding transcription factor activity
RMET_RS07595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RMET_RS07600	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RMET_RS07605	COG3954	Phosphoribulokinase
RMET_RS07610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RMET_RS07615	COG0546	phosphoglycolate phosphatase activity
RMET_RS07620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RMET_RS07625	COG0126	phosphoglycerate kinase activity
RMET_RS07630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RMET_RS07635	COG0191	fructose-bisphosphate aldolase activity
RMET_RS07640	COG0469	pyruvate kinase activity
RMET_RS07645	COG0149	triose-phosphate isomerase activity
RMET_RS07650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RMET_RS07655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RMET_RS07660	COG3383	formate dehydrogenase (NAD+) activity
RMET_RS07665	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
RMET_RS07670	COG3259	Nickel-dependent hydrogenase
RMET_RS07690	COG2826	transposase and inactivated derivatives, IS30 family
RMET_RS07700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RMET_RS07710	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RMET_RS07725	COG0375	protein maturation
RMET_RS07735	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RMET_RS07740	COG0298	carbon dioxide binding
RMET_RS07745	COG0409	Hydrogenase expression formation protein
RMET_RS07750	COG0309	Hydrogenase expression formation protein (HypE)
RMET_RS07755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RMET_RS07755	COG1024	Enoyl-CoA hydratase
RMET_RS07760	COG2204	response regulator
RMET_RS07800	COG4962	Type ii secretion system protein e
RMET_RS07805	COG3838	Conjugal transfer protein Trbc
RMET_RS07815	COG3451	type IV secretory pathway VirB4
RMET_RS07870	COG2801	Transposase and inactivated derivatives
RMET_RS07880	COG0596	Alpha beta hydrolase
RMET_RS07890	COG4191	Histidine kinase
RMET_RS07905	COG0602	queuosine metabolic process
RMET_RS07910	COG0720	synthase
RMET_RS07920	COG1619	proteins homologs of microcin C7 resistance protein MccF
RMET_RS07925	COG0488	(ABC) transporter
RMET_RS07950	COG2258	MOSC domain
RMET_RS07990	COG3829	transcription factor binding
RMET_RS07995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RMET_RS08000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RMET_RS08005	COG0583	DNA-binding transcription factor activity
RMET_RS08010	COG2826	transposase and inactivated derivatives, IS30 family
RMET_RS08015	COG0583	DNA-binding transcription factor activity
RMET_RS08030	COG1674	ftsk spoiiie
RMET_RS08055	COG1846	Transcriptional regulator
RMET_RS08070	COG2207	Transcriptional regulator
RMET_RS08075	COG0583	DNA-binding transcription factor activity
RMET_RS08085	COG1346	cytolysis
RMET_RS08090	COG0277	FAD linked oxidase domain protein
RMET_RS08100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RMET_RS08105	COG0747	negative chemotaxis
RMET_RS08120	COG4166	transmembrane transport
RMET_RS08125	COG0601	transmembrane transport
RMET_RS08130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RMET_RS08140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RMET_RS08150	COG0028	Belongs to the TPP enzyme family
RMET_RS08165	COG1012	belongs to the aldehyde dehydrogenase family
RMET_RS08195	COG3791	Glutathione-dependent formaldehyde-activating
RMET_RS08210	COG2084	Dehydrogenase
RMET_RS08215	COG3836	Belongs to the HpcH HpaI aldolase family
RMET_RS08220	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RMET_RS08230	COG0028	Belongs to the TPP enzyme family
RMET_RS08240	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RMET_RS08245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RMET_RS08275	COG0417	DNA replication proofreading
RMET_RS08280	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RMET_RS08280	COG3264	Mechanosensitive ion channel
RMET_RS08300	COG4452	Inner membrane protein CreD
RMET_RS08305	COG2205	protein histidine kinase activity
RMET_RS08310	COG0745	RESPONSE REGULATOR receiver
RMET_RS08315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RMET_RS08320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RMET_RS08335	COG0435	Glutathione S-transferase
RMET_RS08360	COG3188	usher protein
RMET_RS08375	COG3243	poly(R)-hydroxyalkanoic acid synthase
RMET_RS08380	COG2030	dehydratase
RMET_RS08395	COG0589	response to stress
RMET_RS08400	COG0589	response to stress
RMET_RS08415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RMET_RS08425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RMET_RS08435	COG0842	Transport permease protein
RMET_RS08440	COG1129	ABC transporter
RMET_RS08440	COG0842	Transport permease protein
RMET_RS08445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RMET_RS08465	COG2200	EAL domain
RMET_RS08480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RMET_RS08485	COG0840	transmembrane signaling receptor activity
RMET_RS08495	COG3064	Membrane
RMET_RS08505	COG4191	Histidine kinase
RMET_RS08515	COG4566	intracellular signal transduction
RMET_RS08535	COG1538	Outer membrane efflux protein
RMET_RS08565	COG0628	permease
RMET_RS08575	COG1566	PFAM secretion protein HlyD family protein
RMET_RS08605	COG2175	clavaminate synthase activity
RMET_RS08610	COG0318	PFAM AMP-dependent synthetase and ligase
RMET_RS08615	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS08620	COG1414	Transcriptional regulator
RMET_RS08625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RMET_RS08630	COG1960	acyl-CoA dehydrogenase activity
RMET_RS08635	COG1024	Enoyl-CoA hydratase
RMET_RS08655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS08670	COG3246	L-lysine catabolic process to acetate
RMET_RS08680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RMET_RS08695	COG3038	cytochrome b561
RMET_RS08735	COG0318	PFAM AMP-dependent synthetase and ligase
RMET_RS08790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS08795	COG0583	DNA-binding transcription factor activity
RMET_RS08810	COG0488	(ABC) transporter
RMET_RS08825	COG1253	flavin adenine dinucleotide binding
RMET_RS08845	COG0076	glutamate decarboxylase activity
RMET_RS08865	COG0154	amidase activity
RMET_RS08885	COG0583	DNA-binding transcription factor activity
RMET_RS08890	COG0277	FAD linked oxidase domain protein
RMET_RS08900	COG1283	sodium-dependent phosphate transmembrane transporter activity
RMET_RS08960	COG2186	Transcriptional regulator
RMET_RS08970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RMET_RS08975	COG1136	(ABC) transporter
RMET_RS08985	COG0577	efflux transmembrane transporter activity
RMET_RS08985	COG1136	(ABC) transporter
RMET_RS08990	COG0583	DNA-binding transcription factor activity
RMET_RS09060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RMET_RS09065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RMET_RS09075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS09085	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS09110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RMET_RS09115	COG0668	transmembrane transport
RMET_RS09125	COG0484	heat shock protein binding
RMET_RS09135	COG0084	hydrolase, TatD family'
RMET_RS09145	COG0470	DNA polymerase III
RMET_RS09150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RMET_RS09155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RMET_RS09180	COG2186	Transcriptional regulator
RMET_RS09185	COG2084	Dehydrogenase
RMET_RS09190	COG3395	kinase activity
RMET_RS09195	COG0235	Class ii aldolase
RMET_RS09200	COG2271	Major facilitator Superfamily
RMET_RS09205	COG3622	Belongs to the hyi family
RMET_RS09210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RMET_RS09225	COG0657	acetylesterase activity
RMET_RS09235	COG0596	Alpha beta hydrolase
RMET_RS09240	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS09255	COG2130	NADP-dependent
RMET_RS09270	COG1960	acyl-CoA dehydrogenase activity
RMET_RS09275	COG0183	Belongs to the thiolase family
RMET_RS09280	COG1335	isochorismatase
RMET_RS09285	COG1250	3-hydroxyacyl-CoA dehydrogenase
RMET_RS09285	COG1024	Enoyl-CoA hydratase
RMET_RS09290	COG0833	amino acid
RMET_RS09305	COG0411	ABC transporter
RMET_RS09335	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RMET_RS09340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RMET_RS09345	COG2917	probably involved in intracellular septation
RMET_RS09355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RMET_RS09365	COG0047	phosphoribosylformylglycinamidine synthase activity
RMET_RS09365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RMET_RS09375	COG3706	GGDEF domain
RMET_RS09400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RMET_RS09405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RMET_RS09405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RMET_RS09410	COG0166	Belongs to the GPI family
RMET_RS09415	COG4181	ATPase activity
RMET_RS09425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RMET_RS09440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RMET_RS09445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RMET_RS09450	COG0740	serine-type endopeptidase activity
RMET_RS09455	COG0544	peptidyl-prolyl cis-trans isomerase activity
RMET_RS09460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RMET_RS09460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RMET_RS09465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RMET_RS09495	COG0028	Belongs to the TPP enzyme family
RMET_RS09505	COG0583	DNA-binding transcription factor activity
RMET_RS09515	COG0028	Belongs to the TPP enzyme family
RMET_RS09545	COG1609	Transcriptional regulator
RMET_RS09570	COG3246	L-lysine catabolic process to acetate
RMET_RS09580	COG3485	protocatechuate 3,4-dioxygenase
RMET_RS09600	COG4566	intracellular signal transduction
RMET_RS09625	COG1335	isochorismatase
RMET_RS09640	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS09685	COG0747	negative chemotaxis
RMET_RS09690	COG0601	transmembrane transport
RMET_RS09695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RMET_RS09700	COG4608	Belongs to the ABC transporter superfamily
RMET_RS09705	COG0444	Belongs to the ABC transporter superfamily
RMET_RS09710	COG0154	amidase activity
RMET_RS09775	COG0450	alkyl hydroperoxide reductase
RMET_RS09780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RMET_RS09790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RMET_RS09795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RMET_RS09800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RMET_RS09820	COG0542	response to heat
RMET_RS09830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RMET_RS09835	COG0314	molybdopterin synthase activity
RMET_RS09845	COG0303	'Molybdopterin
RMET_RS09860	COG0436	Aminotransferase
RMET_RS09870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RMET_RS09875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RMET_RS09885	COG0791	NLP P60 protein
RMET_RS09890	COG0306	phosphate transporter
RMET_RS09900	COG0305	Participates in initiation and elongation during chromosome replication
RMET_RS09905	COG0359	binds to the 23S rRNA
RMET_RS09910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RMET_RS09920	COG0360	Binds together with S18 to 16S ribosomal RNA
RMET_RS09925	COG0252	asparaginase activity
RMET_RS09930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RMET_RS09945	COG2985	domain, Protein
RMET_RS09960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RMET_RS10115	COG0431	NADPH-dependent FMN reductase
RMET_RS10120	COG1024	Enoyl-CoA hydratase
RMET_RS10135	COG1846	Transcriptional regulator
RMET_RS10145	COG1566	PFAM secretion protein HlyD family protein
RMET_RS10150	COG2814	Major facilitator Superfamily
RMET_RS10155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RMET_RS10160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RMET_RS10165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RMET_RS10170	COG2251	uridine kinase activity
RMET_RS10170	COG0195	Participates in both transcription termination and antitermination
RMET_RS10175	COG0779	Required for maturation of 30S ribosomal subunits
RMET_RS10180	COG1187	pseudouridine synthase activity
RMET_RS10185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RMET_RS10195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RMET_RS10225	COG3278	Belongs to the heme-copper respiratory oxidase family
RMET_RS10235	COG2217	Heavy metal translocating P-type atpase
RMET_RS10240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RMET_RS10245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RMET_RS10250	COG0508	dehydrogenase complex catalyzes the overall conversion of
RMET_RS10255	COG0567	Dehydrogenase, E1 component
RMET_RS10260	COG0584	glycerophosphoryl diester phosphodiesterase
RMET_RS10265	COG3842	ATPase activity
RMET_RS10270	COG0395	ABC-type sugar transport system, permease component
RMET_RS10275	COG1175	transmembrane transport
RMET_RS10305	COG3852	Histidine kinase
RMET_RS10315	COG0174	glutamine synthetase
RMET_RS10350	COG1643	Atp-dependent helicase
RMET_RS10355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RMET_RS10355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RMET_RS10360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RMET_RS10370	COG2223	nitrite transmembrane transporter activity
RMET_RS10375	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RMET_RS10380	COG1140	nitrate reductase beta subunit
RMET_RS10385	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RMET_RS10390	COG2181	nitrate reductase activity
RMET_RS10395	COG0288	reversible hydration of carbon dioxide
RMET_RS10400	COG2010	Cytochrome c
RMET_RS10405	COG3391	amine dehydrogenase activity
RMET_RS10425	COG2070	2-Nitropropane dioxygenase
RMET_RS10440	COG3850	Histidine kinase
RMET_RS10445	COG2197	response regulator
RMET_RS10450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RMET_RS10455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RMET_RS10460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RMET_RS10465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RMET_RS10470	COG0557	exoribonuclease II activity
RMET_RS10485	COG2910	NAD(P)H-binding
RMET_RS10490	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RMET_RS10495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RMET_RS10500	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RMET_RS10505	COG0330	HflC and HflK could
RMET_RS10510	COG0330	HflC and HflK could
RMET_RS10515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RMET_RS10520	COG1923	regulation of RNA biosynthetic process
RMET_RS10525	COG1160	GTP binding
RMET_RS10540	COG0124	histidyl-tRNA synthetase
RMET_RS10545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RMET_RS10560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RMET_RS10565	COG0105	UTP biosynthetic process
RMET_RS10570	COG0670	Belongs to the BI1 family
RMET_RS10575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RMET_RS10600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RMET_RS10605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RMET_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS10610	COG3321	synthase
RMET_RS10610	COG0604	alcohol dehydrogenase
RMET_RS10615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RMET_RS10625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RMET_RS10635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RMET_RS10640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS10645	COG0583	DNA-binding transcription factor activity
RMET_RS10650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RMET_RS10655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RMET_RS10660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RMET_RS10665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RMET_RS10670	COG1074	ATP-dependent DNA helicase activity
RMET_RS10690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RMET_RS10700	COG0254	rRNA binding
RMET_RS10710	COG0534	Mate efflux family protein
RMET_RS10745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RMET_RS10750	COG1752	Esterase of the alpha-beta hydrolase superfamily
RMET_RS10755	COG0791	NLP P60 protein
RMET_RS10760	COG4172	Belongs to the ABC transporter superfamily
RMET_RS10765	COG4239	(ABC) transporter, permease
RMET_RS10770	COG4174	ABC transporter (Permease)
RMET_RS10790	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RMET_RS10810	COG4566	intracellular signal transduction
RMET_RS10860	COG4962	Type ii secretion system protein e
RMET_RS10915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RMET_RS10920	COG2062	phosphohistidine phosphatase, SixA
RMET_RS10930	COG0248	Ppx GppA phosphatase
RMET_RS10955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RMET_RS10960	COG0581	inorganic phosphate transmembrane transporter activity
RMET_RS10965	COG0573	inorganic phosphate transmembrane transporter activity
RMET_RS10970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RMET_RS10975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RMET_RS10985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RMET_RS10990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RMET_RS10995	COG1534	Rna-binding protein
RMET_RS11005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RMET_RS11010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RMET_RS11020	COG0505	Belongs to the CarA family
RMET_RS11045	COG1024	Enoyl-CoA hydratase
RMET_RS11050	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS11060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RMET_RS11070	COG0741	lytic transglycosylase activity
RMET_RS11070	COG1388	LysM domain
RMET_RS11075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RMET_RS11080	COG2226	methyltransferase
RMET_RS11085	COG0328	RNA-DNA hybrid ribonuclease activity
RMET_RS11090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RMET_RS11110	COG0778	Nitroreductase
RMET_RS11130	COG1960	acyl-CoA dehydrogenase activity
RMET_RS11135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RMET_RS11140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RMET_RS11150	COG1116	anion transmembrane transporter activity
RMET_RS11155	COG2010	Cytochrome c
RMET_RS11165	COG0859	PFAM glycosyl transferase family 9
RMET_RS11170	COG1335	isochorismatase
RMET_RS11200	COG0395	ABC-type sugar transport system, permease component
RMET_RS11215	COG3842	ATPase activity
RMET_RS11235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RMET_RS11270	COG2199	diguanylate cyclase activity
RMET_RS11275	COG2885	chlorophyll binding
RMET_RS11280	COG2202	Pas domain
RMET_RS11280	COG2200	EAL domain
RMET_RS11280	COG2199	diguanylate cyclase activity
RMET_RS11295	COG1215	transferase activity, transferring glycosyl groups
RMET_RS11300	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RMET_RS11305	COG0457	Tetratricopeptide repeat
RMET_RS11325	COG1215	transferase activity, transferring glycosyl groups
RMET_RS11330	COG2194	sulfuric ester hydrolase activity
RMET_RS11385	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RMET_RS11390	COG3328	transposase activity
RMET_RS11395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RMET_RS11400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RMET_RS11405	COG0697	spore germination
RMET_RS11420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RMET_RS11425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RMET_RS11450	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RMET_RS11465	COG2855	membrane
RMET_RS11470	COG0583	DNA-binding transcription factor activity
RMET_RS11475	COG4651	solute:proton antiporter activity
RMET_RS11475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RMET_RS11535	COG0629	single-stranded DNA binding
RMET_RS11540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RMET_RS11555	COG0789	Transcriptional regulator
RMET_RS11565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RMET_RS11605	COG0789	Transcriptional regulator
RMET_RS11760	COG1569	PIN domain
RMET_RS11765	COG3311	Transcriptional regulator
RMET_RS11820	COG2003	Belongs to the UPF0758 family
RMET_RS11875	COG1024	Enoyl-CoA hydratase
RMET_RS11890	COG2814	Major facilitator Superfamily
RMET_RS11895	COG0640	Transcriptional regulator
RMET_RS11900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RMET_RS11930	COG3258	Cytochrome c
RMET_RS11940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RMET_RS11945	COG2826	transposase and inactivated derivatives, IS30 family
RMET_RS11950	COG0642	Histidine kinase
RMET_RS11955	COG0745	RESPONSE REGULATOR receiver
RMET_RS11960	COG4133	protoheme IX ABC transporter activity
RMET_RS11990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RMET_RS11995	COG3088	subunit of a heme lyase
RMET_RS12005	COG4232	protein-disulfide reductase activity
RMET_RS12010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RMET_RS12025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RMET_RS12035	COG0583	DNA-binding transcription factor activity
RMET_RS12045	COG0582	viral genome integration into host DNA
RMET_RS12070	COG0582	viral genome integration into host DNA
RMET_RS12085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RMET_RS12090	COG0322	excinuclease ABC activity
RMET_RS12100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RMET_RS12110	COG0736	holo-[acyl-carrier-protein] synthase activity
RMET_RS12115	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RMET_RS12120	COG1381	Involved in DNA repair and RecF pathway recombination
RMET_RS12125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RMET_RS12130	COG0571	ribonuclease III activity
RMET_RS12140	COG0681	Belongs to the peptidase S26 family
RMET_RS12145	COG0481	GTPase activity
RMET_RS12150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RMET_RS12170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RMET_RS12175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RMET_RS12190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RMET_RS12195	COG0416	fatty acid biosynthetic process
RMET_RS12200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RMET_RS12210	COG0424	maF-like protein
RMET_RS12215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RMET_RS12220	COG0616	signal peptide processing
RMET_RS12220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RMET_RS12240	COG1530	ribonuclease E activity
RMET_RS12245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RMET_RS12250	COG0746	molybdenum cofactor guanylyltransferase activity
RMET_RS12255	COG0303	'Molybdopterin
RMET_RS12265	COG1322	Protein conserved in bacteria
RMET_RS12280	COG1556	Lactate utilization protein
RMET_RS12285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RMET_RS12295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RMET_RS12300	COG0492	ferredoxin-NADP+ reductase activity
RMET_RS12315	COG1280	lysine exporter protein (LysE YggA)
RMET_RS12320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RMET_RS12330	COG1131	(ABC) transporter
RMET_RS12360	COG0285	dihydrofolate synthase activity
RMET_RS12365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RMET_RS12370	COG0159	tryptophan synthase activity
RMET_RS12380	COG0133	tryptophan synthase activity
RMET_RS12385	COG0135	phosphoribosylanthranilate isomerase activity
RMET_RS12390	COG0101	tRNA pseudouridine synthase activity
RMET_RS12400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RMET_RS12405	COG0473	3-isopropylmalate dehydrogenase activity
RMET_RS12410	COG0066	3-isopropylmalate dehydratase activity
RMET_RS12420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RMET_RS12450	COG0372	Belongs to the citrate synthase family
RMET_RS12455	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RMET_RS12460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RMET_RS12465	COG1053	succinate dehydrogenase
RMET_RS12470	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RMET_RS12480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RMET_RS12485	COG0039	L-malate dehydrogenase activity
RMET_RS12500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RMET_RS12510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RMET_RS12565	COG0326	Molecular chaperone. Has ATPase activity
RMET_RS12570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RMET_RS12580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RMET_RS12590	COG0697	spore germination
RMET_RS12600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RMET_RS12605	COG0625	glutathione transferase activity
RMET_RS12610	COG1620	l-lactate permease
RMET_RS12615	COG1132	(ABC) transporter
RMET_RS12650	COG0488	(ABC) transporter
RMET_RS12660	COG0318	PFAM AMP-dependent synthetase and ligase
RMET_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS12680	COG0183	Belongs to the thiolase family
RMET_RS12685	COG1960	acyl-CoA dehydrogenase activity
RMET_RS12690	COG1960	acyl-CoA dehydrogenase activity
RMET_RS12700	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS12715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS12730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RMET_RS12745	COG3135	benzoate transporter
RMET_RS12880	COG0631	protein serine/threonine phosphatase activity
RMET_RS12885	COG0513	Belongs to the DEAD box helicase family
RMET_RS12890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RMET_RS12895	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RMET_RS12900	COG0861	Integral membrane protein TerC family
RMET_RS12905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RMET_RS12915	COG0312	modulator of DNA gyrase
RMET_RS12920	COG3028	Belongs to the UPF0307 family
RMET_RS12925	COG0521	Mo-molybdopterin cofactor biosynthetic process
RMET_RS12935	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RMET_RS12940	COG0501	Belongs to the peptidase M48B family
RMET_RS12945	COG1162	GTPase activity
RMET_RS12960	COG1741	Belongs to the pirin family
RMET_RS12965	COG0583	DNA-binding transcription factor activity
RMET_RS12970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RMET_RS12975	COG0513	Belongs to the DEAD box helicase family
RMET_RS12995	COG1414	Transcriptional regulator
RMET_RS13010	COG3395	kinase activity
RMET_RS13015	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RMET_RS13020	COG1349	DNA-binding transcription factor activity
RMET_RS13050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS13060	COG1960	acyl-CoA dehydrogenase activity
RMET_RS13065	COG1414	Transcriptional regulator
RMET_RS13075	COG0183	Belongs to the thiolase family
RMET_RS13080	COG1024	Enoyl-CoA hydratase
RMET_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS13115	COG1610	YqeY-like protein
RMET_RS13120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RMET_RS13125	COG2081	HI0933 family
RMET_RS13130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RMET_RS13135	COG3540	Alkaline phosphatase
RMET_RS13140	COG1469	GTP cyclohydrolase I activity
RMET_RS13145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RMET_RS13150	COG0142	geranyltranstransferase activity
RMET_RS13155	COG1722	exodeoxyribonuclease VII activity
RMET_RS13180	COG0412	Dienelactone hydrolase
RMET_RS13185	COG1252	NADH dehydrogenase
RMET_RS13190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RMET_RS13190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RMET_RS13195	COG1611	Belongs to the LOG family
RMET_RS13205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RMET_RS13215	COG0210	DNA helicase
RMET_RS13220	COG0525	valine-tRNA ligase activity
RMET_RS13235	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RMET_RS13245	COG0318	PFAM AMP-dependent synthetase and ligase
RMET_RS13250	COG3118	belongs to the thioredoxin family
RMET_RS13265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RMET_RS13270	COG2982	Protein involved in outer membrane biogenesis
RMET_RS13280	COG0259	pyridoxamine-phosphate oxidase activity
RMET_RS13290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RMET_RS13300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RMET_RS13305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RMET_RS13310	COG1522	sequence-specific DNA binding
RMET_RS13325	COG3483	tryptophan 2,3-dioxygenase activity
RMET_RS13340	COG0450	alkyl hydroperoxide reductase
RMET_RS13360	COG3447	MASE1 domain protein
RMET_RS13360	COG5001	Diguanylate cyclase
RMET_RS13360	COG5002	protein histidine kinase activity
RMET_RS13410	COG2391	methyltransferase activity
RMET_RS13415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RMET_RS13425	COG2885	chlorophyll binding
RMET_RS13430	COG0823	Involved in the tonB-independent uptake of proteins
RMET_RS13450	COG0824	Thioesterase
RMET_RS13455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RMET_RS13460	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RMET_RS13495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RMET_RS13495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RMET_RS13515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS13525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RMET_RS13530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RMET_RS13535	COG0436	Aminotransferase
RMET_RS13540	COG0741	lytic transglycosylase activity
RMET_RS13545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RMET_RS13550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RMET_RS13580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RMET_RS13585	COG1968	undecaprenyl-diphosphatase activity
RMET_RS13605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RMET_RS13635	COG0859	PFAM glycosyl transferase family 9
RMET_RS13645	COG0438	transferase activity, transferring glycosyl groups
RMET_RS13650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RMET_RS13655	COG0438	transferase activity, transferring glycosyl groups
RMET_RS13665	COG0438	transferase activity, transferring glycosyl groups
RMET_RS13680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RMET_RS13685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RMET_RS13730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RMET_RS13745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RMET_RS13750	COG0540	Belongs to the ATCase OTCase family
RMET_RS13755	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RMET_RS13760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RMET_RS13765	COG1678	Uncharacterized ACR, COG1678
RMET_RS13770	COG1187	pseudouridine synthase activity
RMET_RS13775	COG0415	Belongs to the DNA photolyase family
RMET_RS13795	COG0181	hydroxymethylbilane synthase activity
RMET_RS13800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RMET_RS13805	COG0165	Argininosuccinate lyase
RMET_RS13825	COG0717	Belongs to the dCTP deaminase family
RMET_RS13830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RMET_RS13835	COG2032	superoxide dismutase activity
RMET_RS13850	COG0437	4 iron, 4 sulfur cluster binding
RMET_RS13855	COG0243	molybdopterin cofactor binding
RMET_RS13855	COG3383	formate dehydrogenase (NAD+) activity
RMET_RS13885	COG0489	protein tyrosine kinase activity
RMET_RS13890	COG2885	chlorophyll binding
RMET_RS13890	COG3047	cAMP biosynthetic process
RMET_RS13895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RMET_RS13895	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RMET_RS13905	COG2911	Protein conserved in bacteria
RMET_RS13920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RMET_RS13925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RMET_RS13945	COG1492	cobalamin metabolic process
RMET_RS13955	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RMET_RS13965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RMET_RS13975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RMET_RS13980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RMET_RS13990	COG1120	ATPase activity
RMET_RS13995	COG4139	cobalamin transport
RMET_RS14000	COG4206	TonB-dependent receptor
RMET_RS14025	COG0318	PFAM AMP-dependent synthetase and ligase
RMET_RS14045	COG1802	Transcriptional regulator
RMET_RS14060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RMET_RS14065	COG0583	DNA-binding transcription factor activity
RMET_RS14070	COG0129	dihydroxy-acid dehydratase activity
RMET_RS14085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RMET_RS14095	COG0795	lipopolysaccharide-transporting ATPase activity
RMET_RS14105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RMET_RS14105	COG1648	precorrin-2 dehydrogenase activity
RMET_RS14110	COG2895	sulfate adenylyltransferase (ATP) activity
RMET_RS14115	COG0175	sulfate reduction
RMET_RS14120	COG0175	sulfate reduction
RMET_RS14135	COG0730	response to heat
RMET_RS14140	COG0583	DNA-binding transcription factor activity
RMET_RS14145	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RMET_RS14155	COG2084	Dehydrogenase
RMET_RS14200	COG3845	ABC transporter
RMET_RS14250	COG2826	transposase and inactivated derivatives, IS30 family
RMET_RS14270	COG5018	Exonuclease
RMET_RS14285	COG0501	Belongs to the peptidase M48B family
RMET_RS14295	COG0402	S-adenosylhomocysteine deaminase activity
RMET_RS14300	COG1228	amidohydrolase
RMET_RS14310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RMET_RS14315	COG2986	histidine ammonia-lyase
RMET_RS14320	COG2188	Transcriptional regulator
RMET_RS14330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RMET_RS14335	COG2358	TRAP transporter, solute receptor (TAXI family
RMET_RS14345	COG0543	2 iron, 2 sulfur cluster binding
RMET_RS14345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RMET_RS14350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RMET_RS14360	COG0411	ABC transporter
RMET_RS14380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RMET_RS14385	COG1047	Peptidyl-prolyl cis-trans
RMET_RS14390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RMET_RS14395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RMET_RS14400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RMET_RS14410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RMET_RS14420	COG0668	transmembrane transport
RMET_RS14425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RMET_RS14425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RMET_RS14430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RMET_RS14435	COG3385	transposase activity
RMET_RS14440	COG2197	response regulator
RMET_RS14445	COG5002	protein histidine kinase activity
RMET_RS14445	COG2198	Histidine kinase
RMET_RS14445	COG0784	Response regulator, receiver
RMET_RS14450	COG3344	reverse transcriptase
RMET_RS14455	COG0196	riboflavin kinase activity
RMET_RS14460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RMET_RS14465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RMET_RS14470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RMET_RS14475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RMET_RS14480	COG0756	dUTP diphosphatase activity
RMET_RS14495	COG0542	response to heat
RMET_RS14500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RMET_RS14505	COG1278	Cold shock
RMET_RS14530	COG1666	GTP binding
RMET_RS14535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RMET_RS14540	COG3123	guanosine phosphorylase activity
RMET_RS14545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RMET_RS14555	COG0268	Binds directly to 16S ribosomal RNA
RMET_RS14560	COG0728	peptidoglycan biosynthetic process
RMET_RS14570	COG0586	Pfam SNARE associated Golgi protein
RMET_RS14575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RMET_RS14580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RMET_RS14590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RMET_RS14595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RMET_RS14610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RMET_RS14620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RMET_RS14625	COG4662	Binding-protein-dependent transport system inner membrane component
RMET_RS14635	COG0512	Glutamine amidotransferase of anthranilate synthase
RMET_RS14635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RMET_RS14640	COG0484	heat shock protein binding
RMET_RS14645	COG0443	Heat shock 70 kDa protein
RMET_RS14650	COG2096	Adenosyltransferase
RMET_RS14655	COG0277	FAD linked oxidase domain protein
RMET_RS14660	COG0583	DNA-binding transcription factor activity
RMET_RS14665	COG0277	FAD linked oxidase domain protein
RMET_RS14670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RMET_RS14675	COG0277	FAD linked oxidase domain protein
RMET_RS14680	COG0247	lactate metabolic process
RMET_RS14685	COG1380	Effector of murein hydrolase LrgA
RMET_RS14690	COG1346	cytolysis
RMET_RS14705	COG0386	Belongs to the glutathione peroxidase family
RMET_RS14730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RMET_RS14735	COG0783	Belongs to the Dps family
RMET_RS14750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RMET_RS14755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RMET_RS14760	COG0343	queuine tRNA-ribosyltransferase activity
RMET_RS14765	COG1862	Preprotein translocase
RMET_RS14770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RMET_RS14775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RMET_RS14780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RMET_RS14785	COG2204	response regulator
RMET_RS14825	COG0625	glutathione transferase activity
RMET_RS14830	COG0482	sulfurtransferase activity
RMET_RS14840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RMET_RS14885	COG1981	membrane
RMET_RS14890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RMET_RS14895	COG1466	dna polymerase III delta subunit
RMET_RS14905	COG0495	leucyl-tRNA aminoacylation
RMET_RS14910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RMET_RS14915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RMET_RS14920	COG0735	belongs to the Fur family
RMET_RS14925	COG0583	DNA-binding transcription factor activity
RMET_RS14930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RMET_RS14935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RMET_RS14940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RMET_RS14945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RMET_RS14955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RMET_RS14980	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RMET_RS15010	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RMET_RS15015	COG0583	DNA-binding transcription factor activity
RMET_RS15035	COG0671	phosphoesterase, PA-phosphatase related
RMET_RS15070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RMET_RS15100	COG3038	cytochrome b561
RMET_RS15110	COG0642	Histidine kinase
RMET_RS15135	COG4959	Type IV secretory pathway protease TraF
RMET_RS15150	COG1192	Involved in chromosome partitioning
RMET_RS15180	COG5489	Protein of unknown function (DUF736)
RMET_RS15255	COG4804	nuclease activity
RMET_RS15275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RMET_RS15280	COG1546	Belongs to the CinA family
RMET_RS15280	COG1058	Belongs to the CinA family
RMET_RS15285	COG0284	orotidine-5'-phosphate decarboxylase activity
RMET_RS15300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RMET_RS15305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RMET_RS15315	COG0557	exoribonuclease II activity
RMET_RS15320	COG1028	Short-chain dehydrogenase reductase Sdr
RMET_RS15325	COG3161	chorismate lyase activity
RMET_RS15335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RMET_RS15345	COG3118	belongs to the thioredoxin family
RMET_RS15350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RMET_RS15355	COG0511	ligase activity, forming carbon-carbon bonds
RMET_RS15365	COG2264	protein methyltransferase activity
RMET_RS15375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RMET_RS15380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RMET_RS15400	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS15410	COG3128	pkhd-type hydroxylase
RMET_RS15415	COG0583	DNA-binding transcription factor activity
RMET_RS15425	COG0656	L-ascorbic acid biosynthetic process
RMET_RS15440	COG2974	May be involved in recombination
RMET_RS15490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RMET_RS15495	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RMET_RS15515	COG0741	lytic transglycosylase activity
RMET_RS15520	COG0442	prolyl-tRNA aminoacylation
RMET_RS15525	COG0494	nUDIX hydrolase
RMET_RS15535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RMET_RS15540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RMET_RS15545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RMET_RS15550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RMET_RS15555	COG0142	geranyltranstransferase activity
RMET_RS15580	COG0237	dephospho-CoA kinase activity
RMET_RS15585	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RMET_RS15590	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RMET_RS15595	COG1297	OPT oligopeptide transporter protein
RMET_RS15600	COG0494	nUDIX hydrolase
RMET_RS15610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RMET_RS15615	COG0653	protein targeting
RMET_RS15620	COG0741	lytic transglycosylase activity
RMET_RS15620	COG1196	nuclear chromosome segregation
RMET_RS15620	COG0739	heme binding
RMET_RS15630	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RMET_RS15635	COG0678	peroxiredoxin activity
RMET_RS15650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RMET_RS15655	COG1181	Belongs to the D-alanine--D-alanine ligase family
RMET_RS15660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RMET_RS15665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RMET_RS15675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RMET_RS15680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RMET_RS15685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RMET_RS15690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RMET_RS15700	COG3116	cell division
RMET_RS15705	COG0275	rRNA processing
RMET_RS15710	COG2001	Belongs to the MraZ family
RMET_RS15715	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RMET_RS15720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RMET_RS15745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RMET_RS15765	COG0318	PFAM AMP-dependent synthetase and ligase
RMET_RS15770	COG1309	transcriptional regulator
RMET_RS15780	COG0243	molybdopterin cofactor binding
RMET_RS15790	COG4608	Belongs to the ABC transporter superfamily
RMET_RS15795	COG0444	Belongs to the ABC transporter superfamily
RMET_RS15800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RMET_RS15805	COG0601	transmembrane transport
RMET_RS15810	COG0747	negative chemotaxis
RMET_RS15815	COG1473	amidohydrolase
RMET_RS15855	COG1024	Enoyl-CoA hydratase
RMET_RS15860	COG1024	Enoyl-CoA hydratase
RMET_RS15865	COG2050	protein possibly involved in aromatic compounds catabolism
RMET_RS15875	COG3604	Transcriptional regulator
RMET_RS15895	COG0535	radical SAM domain protein
RMET_RS15920	COG2967	ApaG domain
RMET_RS15925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RMET_RS15930	COG0546	phosphoglycolate phosphatase activity
RMET_RS15945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RMET_RS15950	COG0134	indole-3-glycerol-phosphate synthase activity
RMET_RS15960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RMET_RS15965	COG1254	Belongs to the acylphosphatase family
RMET_RS15970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RMET_RS15975	COG1116	anion transmembrane transporter activity
RMET_RS15980	COG1289	transmembrane transporter activity
RMET_RS15990	COG0604	alcohol dehydrogenase
RMET_RS15995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RMET_RS16000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RMET_RS16010	COG0012	GTP binding
RMET_RS16035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RMET_RS16045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RMET_RS16050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RMET_RS16060	COG2890	protein-(glutamine-N5) methyltransferase activity
RMET_RS16065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RMET_RS16070	COG0163	prenyltransferase activity
RMET_RS16080	COG1012	belongs to the aldehyde dehydrogenase family
RMET_RS16090	COG1522	sequence-specific DNA binding
RMET_RS16115	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS16145	COG1408	metallophosphoesterase
RMET_RS16150	COG0488	(ABC) transporter
RMET_RS16160	COG1451	nucleotide metabolic process
RMET_RS16180	COG2969	positive regulation of protein catabolic process
RMET_RS16185	COG0625	glutathione transferase activity
RMET_RS16190	COG2857	Cytochrome c1
RMET_RS16195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RMET_RS16200	COG0723	plastoquinol--plastocyanin reductase activity
RMET_RS16205	COG1970	mechanosensitive ion channel activity
RMET_RS16210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RMET_RS16215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RMET_RS16220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RMET_RS16225	COG0805	protein transport
RMET_RS16230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RMET_RS16235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RMET_RS16250	COG0140	phosphoribosyl-ATP diphosphatase activity
RMET_RS16255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RMET_RS16260	COG0107	imidazoleglycerol-phosphate synthase activity
RMET_RS16265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RMET_RS16270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RMET_RS16275	COG2095	MarC family integral membrane protein
RMET_RS16280	COG0131	Imidazoleglycerol-phosphate dehydratase
RMET_RS16285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RMET_RS16290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RMET_RS16295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RMET_RS16300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RMET_RS16305	COG5007	Belongs to the BolA IbaG family
RMET_RS16310	COG0842	Transport permease protein
RMET_RS16315	COG1131	(ABC) transporter
RMET_RS16330	COG2853	Lipoprotein
RMET_RS16335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RMET_RS16340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RMET_RS16345	COG1127	ABC transporter
RMET_RS16350	COG3181	Tripartite tricarboxylate transporter family receptor
RMET_RS16365	COG0069	glutamate synthase activity
RMET_RS16365	COG0067	glutamate synthase
RMET_RS16365	COG0070	glutamate synthase
RMET_RS16375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RMET_RS16380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RMET_RS16385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RMET_RS16420	COG1965	Belongs to the frataxin family
RMET_RS16430	COG0019	diaminopimelate decarboxylase activity
RMET_RS16435	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RMET_RS16440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RMET_RS16460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RMET_RS16465	COG1333	cytochrome c biogenesis protein
RMET_RS16475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RMET_RS16485	COG0598	Magnesium transport protein CorA
RMET_RS16490	COG4232	protein-disulfide reductase activity
RMET_RS16495	COG1324	tolerance protein
RMET_RS16500	COG0203	ribosomal protein L17
RMET_RS16505	COG0202	RNA polymerase activity
RMET_RS16510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RMET_RS16515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RMET_RS16520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RMET_RS16525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RMET_RS16530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RMET_RS16535	COG0201	protein transport
RMET_RS16540	COG0200	Binds to the 23S rRNA
RMET_RS16545	COG1841	ribosomal large subunit assembly
RMET_RS16550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RMET_RS16555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RMET_RS16560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RMET_RS16565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RMET_RS16570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RMET_RS16575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RMET_RS16580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RMET_RS16585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RMET_RS16590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RMET_RS16595	COG0255	Belongs to the universal ribosomal protein uL29 family
RMET_RS16600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RMET_RS16605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RMET_RS16610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RMET_RS16615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RMET_RS16620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RMET_RS16625	COG0089	rRNA binding
RMET_RS16630	COG0088	Forms part of the polypeptide exit tunnel
RMET_RS16635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RMET_RS16665	COG0051	transcription antitermination factor activity, RNA binding
RMET_RS16670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RMET_RS16675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RMET_RS16680	COG0049	tRNA binding
RMET_RS16685	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RMET_RS16690	COG0514	ATP-dependent DNA helicase (RecQ)
RMET_RS16695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RMET_RS16715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RMET_RS16720	COG0085	RNA polymerase activity
RMET_RS16725	COG0222	ribosome binding
RMET_RS16730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RMET_RS16735	COG0081	regulation of translation
RMET_RS16740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RMET_RS16760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RMET_RS16810	COG0700	Nucleoside recognition
RMET_RS16890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RMET_RS16925	COG3396	Phenylacetate-CoA oxygenase
RMET_RS16930	COG3460	Phenylacetate-CoA oxygenase
RMET_RS16935	COG3396	Phenylacetate-CoA oxygenase
RMET_RS16940	COG2151	metal-sulfur cluster biosynthetic enzyme
RMET_RS16945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RMET_RS16995	COG1959	2 iron, 2 sulfur cluster binding
RMET_RS17025	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RMET_RS17080	COG2223	nitrite transmembrane transporter activity
RMET_RS17085	COG3384	dioxygenase
RMET_RS17100	COG2818	Glycosylase
RMET_RS17105	COG1280	lysine exporter protein (LysE YggA)
RMET_RS17120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RMET_RS17140	COG1960	acyl-CoA dehydrogenase activity
RMET_RS17145	COG1024	Enoyl-CoA hydratase
RMET_RS17170	COG0737	Belongs to the 5'-nucleotidase family
RMET_RS17175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RMET_RS17180	COG2010	Cytochrome c
RMET_RS17205	COG4654	Cytochrome c, class I
RMET_RS17215	COG0446	pyridine nucleotide-disulphide oxidoreductase
RMET_RS17225	COG2823	Periplasmic or secreted lipoprotein
RMET_RS17230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RMET_RS17235	COG0792	nuclease activity
RMET_RS17250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RMET_RS17265	COG1393	Belongs to the ArsC family
RMET_RS17275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RMET_RS17285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RMET_RS17295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RMET_RS17305	COG1301	dicarboxylic acid transport
RMET_RS17315	COG0583	DNA-binding transcription factor activity
RMET_RS17325	COG3960	tartronate-semialdehyde synthase activity
RMET_RS17330	COG3622	Belongs to the hyi family
RMET_RS17335	COG2084	Dehydrogenase
RMET_RS17345	COG0469	pyruvate kinase activity
RMET_RS17350	COG2321	neutral zinc metallopeptidase
RMET_RS17360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RMET_RS17365	COG0789	Transcriptional regulator
RMET_RS17370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RMET_RS17385	COG3766	membrane
RMET_RS17390	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RMET_RS17405	COG0501	Belongs to the peptidase M48B family
RMET_RS17410	COG2207	Transcriptional regulator
RMET_RS17410	COG1917	Cupin 2, conserved barrel domain protein
RMET_RS17415	COG2814	Major facilitator Superfamily
RMET_RS17420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RMET_RS17420	COG2124	cytochrome p450
RMET_RS17455	COG3245	cytochrome
RMET_RS17460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RMET_RS17480	COG0210	DNA helicase
RMET_RS17490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RMET_RS17495	COG0509	glycine decarboxylation via glycine cleavage system
RMET_RS17500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RMET_RS17500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RMET_RS17505	COG1760	l-serine dehydratase
RMET_RS17510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RMET_RS17515	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RMET_RS17530	COG0683	leucine binding
RMET_RS17535	COG0506	proline dehydrogenase activity
RMET_RS17535	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RMET_RS17535	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RMET_RS17540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RMET_RS17545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RMET_RS17550	COG0657	acetylesterase activity
RMET_RS17555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RMET_RS17560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RMET_RS17565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RMET_RS17570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RMET_RS17575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RMET_RS17580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RMET_RS17590	COG0356	it plays a direct role in the translocation of protons across the membrane
RMET_RS17605	COG1192	Involved in chromosome partitioning
RMET_RS17610	COG0357	Ribosomal RNA small subunit methyltransferase G
RMET_RS17615	COG0445	tRNA wobble uridine modification
RMET_RS17630	COG0583	DNA-binding transcription factor activity
RMET_RS17670	COG0559	Belongs to the binding-protein-dependent transport system permease family
RMET_RS17690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RMET_RS17695	COG2267	carboxylic ester hydrolase activity
RMET_RS17700	COG0789	Transcriptional regulator
RMET_RS17705	COG2217	Heavy metal translocating P-type atpase
RMET_RS17715	COG3047	cAMP biosynthetic process
RMET_RS17720	COG2423	ornithine cyclodeaminase activity
RMET_RS17725	COG0667	Aldo Keto reductase
RMET_RS17730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RMET_RS17745	COG1522	sequence-specific DNA binding
RMET_RS17750	COG3186	Phenylalanine-4-hydroxylase
RMET_RS17755	COG2154	pterin-4-alpha-carbinolamine dehydratase
RMET_RS17765	COG0642	Histidine kinase
RMET_RS17785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RMET_RS17795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RMET_RS17805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RMET_RS17810	COG2814	Major facilitator Superfamily
RMET_RS17850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RMET_RS17860	COG0154	amidase activity
RMET_RS17870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RMET_RS17880	COG2204	response regulator
RMET_RS17885	COG5000	phosphorelay sensor kinase activity
RMET_RS17900	COG0501	Belongs to the peptidase M48B family
RMET_RS17905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RMET_RS17910	COG0242	peptide deformylase activity
RMET_RS17920	COG0758	DNA mediated transformation
RMET_RS17935	COG0583	DNA-binding transcription factor activity
RMET_RS17950	COG2879	small protein
RMET_RS17955	COG1966	Carbon starvation protein
RMET_RS17970	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RMET_RS17975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RMET_RS17985	COG2258	MOSC domain
RMET_RS18020	COG1309	transcriptional regulator
RMET_RS18025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RMET_RS18030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RMET_RS18085	COG0596	Alpha beta hydrolase
RMET_RS18085	COG0508	dehydrogenase complex catalyzes the overall conversion of
RMET_RS18095	COG0789	Transcriptional regulator
RMET_RS18100	COG0583	DNA-binding transcription factor activity
RMET_RS18135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RMET_RS18145	COG4106	trans-aconitate 2-methyltransferase activity
RMET_RS18150	COG0706	membrane insertase activity
RMET_RS18155	COG0594	ribonuclease P activity
RMET_RS18160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RMET_RS18265	COG0179	Fumarylacetoacetate (FAA) hydrolase
RMET_RS18450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RMET_RS18650	COG1960	acyl-CoA dehydrogenase activity
RMET_RS18685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RMET_RS18950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RMET_RS18990	COG0617	tRNA 3'-terminal CCA addition
RMET_RS19025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RMET_RS19305	COG0004	ammonium transporteR
RMET_RS19335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RMET_RS19415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RMET_RS19510	COG0612	Peptidase, M16
RMET_RS19870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RMET_RS19980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RMET_RS20105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RMET_RS20380	COG0477	Major facilitator Superfamily
RMET_RS20605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RMET_RS20730	COG2271	Major facilitator Superfamily
RMET_RS20765	COG2610	gluconate transmembrane transporter activity
RMET_RS20965	COG3008	intermembrane lipid transfer
RMET_RS21160	COG4770	biotin carboxylase activity
RMET_RS21615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RMET_RS21670	COG0189	ligase activity
RMET_RS21670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RMET_RS21765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RMET_RS21820	COG2233	PERMEase
RMET_RS21935	COG1132	(ABC) transporter
RMET_RS21975	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RMET_RS21990	COG2271	Major facilitator Superfamily
RMET_RS22035	COG0217	transcriptional regulatory protein
RMET_RS22945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RMET_RS22970	COG0405	Gamma-glutamyltransferase
RMET_RS23100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RMET_RS23215	COG0556	nucleotide-excision repair
RMET_RS23430	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RMET_RS23480	COG0483	inositol monophosphate 1-phosphatase activity
RMET_RS23710	COG0243	molybdopterin cofactor binding
RMET_RS23735	COG1295	ribonuclease BN
RMET_RS24030	COG0339	signal peptide processing
RMET_RS24060	COG0784	Response regulator, receiver
RMET_RS24060	COG4191	Histidine kinase
RMET_RS24125	COG1122	ATPase activity
RMET_RS24400	COG0842	Transport permease protein
RMET_RS24710	COG0564	pseudouridine synthase activity
RMET_RS24725	COG3243	poly(R)-hydroxyalkanoic acid synthase
RMET_RS24805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RMET_RS25055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RMET_RS25175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RMET_RS25935	COG1012	belongs to the aldehyde dehydrogenase family
RMET_RS25955	COG0642	Histidine kinase
RMET_RS26000	COG0028	Belongs to the TPP enzyme family
RMET_RS26160	COG3188	usher protein
RMET_RS26455	COG0439	Biotin carboxylase
RMET_RS26470	COG0439	Biotin carboxylase
RMET_RS27175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RMET_RS27185	COG2917	probably involved in intracellular septation
RMET_RS27610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RMET_RS27635	COG0542	response to heat
RMET_RS27855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RMET_RS27860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RMET_RS27890	COG1187	pseudouridine synthase activity
RMET_RS27935	COG3278	Belongs to the heme-copper respiratory oxidase family
RMET_RS27970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RMET_RS28130	COG2223	nitrite transmembrane transporter activity
RMET_RS28475	COG0534	Mate efflux family protein
RMET_RS28515	COG4172	Belongs to the ABC transporter superfamily
RMET_RS28530	COG4174	ABC transporter (Permease)
RMET_RS28905	COG0741	lytic transglycosylase activity
RMET_RS28905	COG1388	LysM domain
RMET_RS29085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RMET_RS29245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RMET_RS29735	COG0513	Belongs to the DEAD box helicase family
RMET_RS29900	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RMET_RS29905	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RMET_RS29910	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RMET_RS29930	COG2205	protein histidine kinase activity
RMET_RS30025	COG0772	Belongs to the SEDS family
RMET_RS30045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RMET_RS30210	COG0018	arginyl-trna synthetase
RMET_RS30455	COG2326	polyphosphate kinase activity
RMET_RS30730	COG0596	Alpha beta hydrolase
RMET_RS30785	COG1703	isobutyryl-CoA mutase activity
RMET_RS30785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RMET_RS30785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RMET_RS30800	COG1250	3-hydroxyacyl-CoA dehydrogenase
RMET_RS31225	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RMET_RS31360	COG0646	methionine synthase
RMET_RS31360	COG1410	methionine synthase
RMET_RS31460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RMET_RS31510	COG0523	cobalamin synthesis protein
RMET_RS31845	COG1804	L-carnitine dehydratase bile acid-inducible protein F