locus-tag	class	description
EHF44_RS00005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EHF44_RS00055	COG1815	bacterial-type flagellum-dependent cell motility
EHF44_RS00070	COG0463	Glycosyl transferase, family 2
EHF44_RS00080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHF44_RS00105	COG1027	Aspartate ammonia-lyase
EHF44_RS00115	COG2271	Major facilitator Superfamily
EHF44_RS00135	COG0745	RESPONSE REGULATOR receiver
EHF44_RS00160	COG0582	viral genome integration into host DNA
EHF44_RS00185	COG1126	abc transporter atp-binding protein
EHF44_RS00190	COG0765	amino acid transport
EHF44_RS00195	COG0765	amino acid transport
EHF44_RS00210	COG0859	PFAM glycosyl transferase family 9
EHF44_RS00220	COG4974	Belongs to the 'phage' integrase family
EHF44_RS00285	COG3620	sequence-specific DNA binding
EHF44_RS00335	COG1192	Involved in chromosome partitioning
EHF44_RS00340	COG1475	DNA binding
EHF44_RS00480	COG5377	YqaJ viral recombinase family
EHF44_RS00850	COG4232	protein-disulfide reductase activity
EHF44_RS00930	COG2916	Histone family protein nucleoid-structuring protein H-NS
EHF44_RS01075	COG0681	Belongs to the peptidase S26 family
EHF44_RS01090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EHF44_RS01140	COG1994	Peptidase M50
EHF44_RS01200	COG4584	PFAM Integrase catalytic
EHF44_RS01205	COG1484	DNA-dependent DNA replication
EHF44_RS01285	COG3038	cytochrome b561
EHF44_RS01380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHF44_RS01425	COG2974	May be involved in recombination
EHF44_RS01460	COG2885	chlorophyll binding
EHF44_RS01460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHF44_RS01535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHF44_RS01555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHF44_RS01575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHF44_RS01590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EHF44_RS01680	COG1785	Belongs to the alkaline phosphatase family
EHF44_RS01700	COG1803	Methylglyoxal synthase
EHF44_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS01710	COG0697	spore germination
EHF44_RS01725	COG0433	COG0433 Predicted ATPase
EHF44_RS01730	COG0217	transcriptional regulatory protein
EHF44_RS01735	COG0151	Belongs to the GarS family
EHF44_RS01740	COG0408	coproporphyrinogen oxidase activity
EHF44_RS01745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EHF44_RS01750	COG0799	negative regulation of ribosome biogenesis
EHF44_RS01755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EHF44_RS01760	COG0424	maF-like protein
EHF44_RS01765	COG1530	ribonuclease E activity
EHF44_RS01770	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EHF44_RS01775	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EHF44_RS01780	COG3639	organic phosphonate transmembrane transporter activity
EHF44_RS01790	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EHF44_RS01795	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EHF44_RS01800	COG3454	Phosphonate metabolism
EHF44_RS01805	COG2188	Transcriptional regulator
EHF44_RS01810	COG3624	Phosphonate C-P lyase system protein PhnG
EHF44_RS01820	COG3626	phosphonate metabolism
EHF44_RS01825	COG3627	carbon phosphorus lyase activity
EHF44_RS01830	COG4107	phosphonate C-P lyase system protein PhnK
EHF44_RS01835	COG4778	phosphonate C-P lyase system protein PhnL
EHF44_RS01840	COG3454	Phosphonate metabolism
EHF44_RS01855	COG1132	(ABC) transporter
EHF44_RS01875	COG1054	Belongs to the UPF0176 family
EHF44_RS01885	COG0335	large ribosomal subunit rRNA binding
EHF44_RS01890	COG0336	Belongs to the RNA methyltransferase TrmD family
EHF44_RS01895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EHF44_RS01900	COG0228	four-way junction DNA binding
EHF44_RS01925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHF44_RS01930	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS01950	COG2011	ABC-type metal ion transport system permease component
EHF44_RS01955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EHF44_RS01960	COG0123	including yeast histone deacetylase and acetoin utilization protein
EHF44_RS01965	COG2951	lytic endotransglycosylase activity
EHF44_RS01975	COG2233	PERMEase
EHF44_RS01980	COG0587	DNA-directed DNA polymerase activity
EHF44_RS01985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF44_RS01990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EHF44_RS02000	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EHF44_RS02010	COG0776	regulation of translation
EHF44_RS02020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EHF44_RS02030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EHF44_RS02035	COG0287	Prephenate dehydrogenase
EHF44_RS02040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHF44_RS02045	COG0077	Prephenate dehydratase
EHF44_RS02045	COG1605	Chorismate mutase
EHF44_RS02050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EHF44_RS02070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHF44_RS02105	COG1132	(ABC) transporter
EHF44_RS02110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHF44_RS02110	COG0189	ligase activity
EHF44_RS02115	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHF44_RS02115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHF44_RS02125	COG0765	amino acid transport
EHF44_RS02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF44_RS02140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHF44_RS02145	COG0583	DNA-binding transcription factor activity
EHF44_RS02150	COG1253	flavin adenine dinucleotide binding
EHF44_RS02160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHF44_RS02180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EHF44_RS02195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EHF44_RS02200	COG1674	ftsk spoiiie
EHF44_RS02205	COG0492	ferredoxin-NADP+ reductase activity
EHF44_RS02210	COG2840	Smr protein MutS2
EHF44_RS02215	COG2860	membrane
EHF44_RS02220	COG0347	Belongs to the P(II) protein family
EHF44_RS02225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EHF44_RS02225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHF44_RS02235	COG3038	cytochrome b561
EHF44_RS02240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EHF44_RS02260	COG2271	Major facilitator Superfamily
EHF44_RS02265	COG2198	Histidine kinase
EHF44_RS02265	COG0643	Histidine kinase
EHF44_RS02290	COG1773	rubredoxin
EHF44_RS02295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EHF44_RS02300	COG1704	LemA family
EHF44_RS02320	COG0583	DNA-binding transcription factor activity
EHF44_RS02345	COG4964	Belongs to the GSP D family
EHF44_RS02390	COG0459	protein refolding
EHF44_RS02395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHF44_RS02430	COG5002	protein histidine kinase activity
EHF44_RS02430	COG5001	Diguanylate cyclase
EHF44_RS02430	COG3447	MASE1 domain protein
EHF44_RS02435	COG1301	dicarboxylic acid transport
EHF44_RS02440	COG4191	Histidine kinase
EHF44_RS02455	COG2423	ornithine cyclodeaminase activity
EHF44_RS02475	COG0516	GMP reductase activity
EHF44_RS02475	COG0517	IMP dehydrogenase activity
EHF44_RS02480	COG0628	permease
EHF44_RS02490	COG2995	paraquat-inducible protein a
EHF44_RS02495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHF44_RS02495	COG3008	intermembrane lipid transfer
EHF44_RS02510	COG3539	Fimbrial protein
EHF44_RS02515	COG3121	Chaperone
EHF44_RS02520	COG3188	usher protein
EHF44_RS02550	COG4149	molybdate abc transporter
EHF44_RS02555	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EHF44_RS02570	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHF44_RS02585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHF44_RS02590	COG2365	Tyrosine phosphatase family
EHF44_RS02595	COG0471	metal ion transport
EHF44_RS02600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EHF44_RS02605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EHF44_RS02610	COG1285	pathogenesis
EHF44_RS02620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHF44_RS02625	COG3383	formate dehydrogenase (NAD+) activity
EHF44_RS02640	COG1910	domain protein
EHF44_RS02665	COG2610	gluconate transmembrane transporter activity
EHF44_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS02675	COG4689	acetoacetate decarboxylase
EHF44_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS02690	COG4566	intracellular signal transduction
EHF44_RS02700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHF44_RS02705	COG1764	response to oxidative stress
EHF44_RS02710	COG1090	epimerase
EHF44_RS02725	COG0583	DNA-binding transcription factor activity
EHF44_RS02740	COG1570	exodeoxyribonuclease VII activity
EHF44_RS02745	COG0811	peptide transport
EHF44_RS02755	COG1663	tetraacyldisaccharide 4'-kinase activity
EHF44_RS02760	COG2835	tetraacyldisaccharide 4'-kinase activity
EHF44_RS02765	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EHF44_RS02770	COG0563	adenylate kinase activity
EHF44_RS02780	COG0583	DNA-binding transcription factor activity
EHF44_RS02790	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHF44_RS02795	COG0802	atpase or kinase
EHF44_RS02800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EHF44_RS02815	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS02825	COG4974	Belongs to the 'phage' integrase family
EHF44_RS02830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EHF44_RS02835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHF44_RS02855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHF44_RS02860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHF44_RS02890	COG0009	L-threonylcarbamoyladenylate synthase
EHF44_RS02895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EHF44_RS02900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EHF44_RS02905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EHF44_RS02915	COG0469	pyruvate kinase activity
EHF44_RS02920	COG0126	phosphoglycerate kinase activity
EHF44_RS02945	COG2814	Major facilitator Superfamily
EHF44_RS02955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHF44_RS02970	COG0859	PFAM glycosyl transferase family 9
EHF44_RS02980	COG0429	hydrolase of the alpha beta-hydrolase fold
EHF44_RS02995	COG0315	cyclic pyranopterin monophosphate synthase activity
EHF44_RS03005	COG0076	glutamate decarboxylase activity
EHF44_RS03025	COG0642	Histidine kinase
EHF44_RS03035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EHF44_RS03040	COG2137	regulation of response to DNA damage stimulus
EHF44_RS03050	COG0045	succinate-CoA ligase (ADP-forming) activity
EHF44_RS03055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EHF44_RS03060	COG0861	Integral membrane protein TerC family
EHF44_RS03095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EHF44_RS03100	COG0513	Belongs to the DEAD box helicase family
EHF44_RS03105	COG0038	chloride channel
EHF44_RS03115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHF44_RS03120	COG1702	phosphate starvation-inducible protein PhoH
EHF44_RS03125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EHF44_RS03130	COG4535	Mg2 and Co2 transporter CorC
EHF44_RS03135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EHF44_RS03140	COG0752	glycyl-tRNA synthetase alpha subunit
EHF44_RS03150	COG0751	glycine-tRNA ligase activity
EHF44_RS03155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHF44_RS03160	COG0204	Acyl-transferase
EHF44_RS03175	COG0346	lactoylglutathione lyase activity
EHF44_RS03190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EHF44_RS03195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EHF44_RS03200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHF44_RS03205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EHF44_RS03230	COG0006	proline dipeptidase activity
EHF44_RS03240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHF44_RS03250	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EHF44_RS03255	COG0138	bifunctional purine biosynthesis protein purh
EHF44_RS03260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EHF44_RS03265	COG0584	glycerophosphoryl diester phosphodiesterase
EHF44_RS03270	COG0632	four-way junction helicase activity
EHF44_RS03275	COG2255	four-way junction helicase activity
EHF44_RS03300	COG1881	PFAM PEBP family protein
EHF44_RS03305	COG1490	D-aminoacyl-tRNA deacylase activity
EHF44_RS03310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHF44_RS03320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EHF44_RS03325	COG0316	Belongs to the HesB IscA family
EHF44_RS03335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EHF44_RS03340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EHF44_RS03345	COG1765	OsmC-like protein
EHF44_RS03360	COG0418	dihydroorotase activity
EHF44_RS03370	COG0473	3-isopropylmalate dehydrogenase activity
EHF44_RS03375	COG0121	glutamine amidotransferase
EHF44_RS03380	COG1126	abc transporter atp-binding protein
EHF44_RS03385	COG0765	amino acid transport
EHF44_RS03390	COG0765	amino acid transport
EHF44_RS03400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EHF44_RS03415	COG1522	sequence-specific DNA binding
EHF44_RS03420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF44_RS03425	COG1116	anion transmembrane transporter activity
EHF44_RS03435	COG5265	(ABC) transporter
EHF44_RS03440	COG1607	acyl-coa hydrolase
EHF44_RS03445	COG1024	Enoyl-CoA hydratase
EHF44_RS03450	COG1307	EDD domain protein, DegV family
EHF44_RS03455	COG0183	Belongs to the thiolase family
EHF44_RS03460	COG1024	Enoyl-CoA hydratase
EHF44_RS03460	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHF44_RS03465	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS03480	COG1763	Mo-molybdopterin cofactor biosynthetic process
EHF44_RS03485	COG3568	Endonuclease Exonuclease Phosphatase
EHF44_RS03490	COG0494	nUDIX hydrolase
EHF44_RS03500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EHF44_RS03520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHF44_RS03535	COG2226	methyltransferase
EHF44_RS03545	COG4178	(ABC) transporter
EHF44_RS03560	COG1238	metal cluster binding
EHF44_RS03605	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EHF44_RS03620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EHF44_RS03625	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHF44_RS03625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHF44_RS03645	COG1131	(ABC) transporter
EHF44_RS03650	COG0842	Transport permease protein
EHF44_RS03665	COG0436	Aminotransferase
EHF44_RS03675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHF44_RS03710	COG1126	abc transporter atp-binding protein
EHF44_RS03715	COG0765	amino acid transport
EHF44_RS03720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF44_RS03740	COG2985	domain, Protein
EHF44_RS03745	COG0387	Pfam Sodium calcium exchanger
EHF44_RS03795	COG0629	single-stranded DNA binding
EHF44_RS03800	COG2814	Major facilitator Superfamily
EHF44_RS03815	COG1283	sodium-dependent phosphate transmembrane transporter activity
EHF44_RS03820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHF44_RS03825	COG0693	protein deglycase activity
EHF44_RS03855	COG1137	ATPase activity
EHF44_RS03860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EHF44_RS03865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHF44_RS03875	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EHF44_RS03885	COG1660	Displays ATPase and GTPase activities
EHF44_RS03895	COG1194	a g-specific adenine glycosylase
EHF44_RS03905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHF44_RS03915	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EHF44_RS03920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EHF44_RS03930	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EHF44_RS03935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EHF44_RS03940	COG0193	aminoacyl-tRNA hydrolase activity
EHF44_RS03945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EHF44_RS03950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EHF44_RS03955	COG0742	ribosomal rna small subunit methyltransferase
EHF44_RS03960	COG0612	Peptidase, M16
EHF44_RS03965	COG0612	Peptidase, M16
EHF44_RS03980	COG0625	glutathione transferase activity
EHF44_RS03995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHF44_RS04000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF44_RS04005	COG1116	anion transmembrane transporter activity
EHF44_RS04010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHF44_RS04015	COG1741	Belongs to the pirin family
EHF44_RS04020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EHF44_RS04025	COG1999	signal sequence binding
EHF44_RS04030	COG0109	protoheme IX farnesyltransferase activity
EHF44_RS04035	COG1612	heme a metabolic process
EHF44_RS04065	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EHF44_RS04070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHF44_RS04085	COG2226	methyltransferase
EHF44_RS04100	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS04105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHF44_RS04110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EHF44_RS04115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHF44_RS04120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHF44_RS04125	COG0588	phosphoglycerate mutase activity
EHF44_RS04130	COG0793	Belongs to the peptidase S41A family
EHF44_RS04135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EHF44_RS04150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHF44_RS04155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHF44_RS04165	COG0189	ligase activity
EHF44_RS04240	COG0004	ammonium transporteR
EHF44_RS04265	COG1280	lysine exporter protein (LysE YggA)
EHF44_RS04280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHF44_RS04300	COG2204	response regulator
EHF44_RS04305	COG4191	Histidine kinase
EHF44_RS04310	COG1301	dicarboxylic acid transport
EHF44_RS04315	COG3411	Ferredoxin
EHF44_RS04320	COG2945	thiolester hydrolase activity
EHF44_RS04325	COG1686	Belongs to the peptidase S11 family
EHF44_RS04330	COG2921	Belongs to the UPF0250 family
EHF44_RS04335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHF44_RS04345	COG2832	Protein of unknown function (DUF454)
EHF44_RS04380	COG1022	Amp-dependent synthetase and ligase
EHF44_RS04390	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHF44_RS04395	COG0537	adenosine 5'-monophosphoramidase activity
EHF44_RS04400	COG1703	isobutyryl-CoA mutase activity
EHF44_RS04400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EHF44_RS04400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EHF44_RS04415	COG0531	amino acid
EHF44_RS04425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHF44_RS04430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS04470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHF44_RS04470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHF44_RS04475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHF44_RS04480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EHF44_RS04490	COG0037	tRNA processing
EHF44_RS04515	COG0617	tRNA 3'-terminal CCA addition
EHF44_RS04530	COG0741	lytic transglycosylase activity
EHF44_RS04535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EHF44_RS04540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EHF44_RS04545	COG1950	PFAM Membrane protein of
EHF44_RS04550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EHF44_RS04555	COG0351	phosphomethylpyrimidine kinase
EHF44_RS04575	COG2022	thiamine diphosphate biosynthetic process
EHF44_RS04590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EHF44_RS04595	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS04620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EHF44_RS04635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EHF44_RS04640	COG2326	polyphosphate kinase activity
EHF44_RS04650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EHF44_RS04655	COG0708	Exodeoxyribonuclease III
EHF44_RS04660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EHF44_RS04670	COG2223	nitrite transmembrane transporter activity
EHF44_RS04680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF44_RS04680	COG2813	Specifically methylates the guanine in position
EHF44_RS04685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF44_RS04690	COG1309	transcriptional regulator
EHF44_RS04700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHF44_RS04710	COG0583	DNA-binding transcription factor activity
EHF44_RS04715	COG2847	Copper chaperone PCu(A)C
EHF44_RS04725	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EHF44_RS04740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EHF44_RS04745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EHF44_RS04760	COG0523	cobalamin synthesis protein
EHF44_RS04780	COG4206	TonB-dependent receptor
EHF44_RS04790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF44_RS04810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHF44_RS04820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EHF44_RS04825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EHF44_RS04830	COG0156	8-amino-7-oxononanoate synthase activity
EHF44_RS04850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHF44_RS04855	COG3012	SEC-C Motif Domain Protein
EHF44_RS04860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHF44_RS04870	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS04880	COG0183	Belongs to the thiolase family
EHF44_RS04885	COG0288	reversible hydration of carbon dioxide
EHF44_RS04890	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EHF44_RS04895	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS04915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHF44_RS04925	COG0018	arginyl-trna synthetase
EHF44_RS04940	COG5487	UPF0391 membrane protein
EHF44_RS04950	COG2201	protein-glutamate methylesterase activity
EHF44_RS04955	COG2197	response regulator
EHF44_RS04965	COG1410	methionine synthase
EHF44_RS04965	COG0646	methionine synthase
EHF44_RS04985	COG0596	Alpha beta hydrolase
EHF44_RS05020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EHF44_RS05030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EHF44_RS05035	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EHF44_RS05035	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EHF44_RS05040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHF44_RS05045	COG1127	ABC transporter
EHF44_RS05080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EHF44_RS05095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHF44_RS05100	COG1984	allophanate hydrolase subunit 2
EHF44_RS05105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHF44_RS05110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHF44_RS05115	COG0321	lipoyl(octanoyl) transferase activity
EHF44_RS05125	COG0583	DNA-binding transcription factor activity
EHF44_RS05130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHF44_RS05140	COG0772	Belongs to the SEDS family
EHF44_RS05145	COG0768	penicillin binding
EHF44_RS05155	COG1792	Involved in formation and maintenance of cell shape
EHF44_RS05160	COG1077	Cell shape determining protein MreB Mrl
EHF44_RS05165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EHF44_RS05170	COG0154	amidase activity
EHF44_RS05185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EHF44_RS05190	COG5295	Hep Hag repeat protein
EHF44_RS05205	COG0745	RESPONSE REGULATOR receiver
EHF44_RS05210	COG2205	protein histidine kinase activity
EHF44_RS05215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EHF44_RS05220	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EHF44_RS05225	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EHF44_RS05235	COG0598	Magnesium transport protein CorA
EHF44_RS05240	COG0850	regulation of cytokinetic process
EHF44_RS05245	COG2894	cell division
EHF44_RS05250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EHF44_RS05255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS05280	COG2223	nitrite transmembrane transporter activity
EHF44_RS05285	COG2207	Transcriptional regulator
EHF44_RS05290	COG1473	amidohydrolase
EHF44_RS05310	COG0517	IMP dehydrogenase activity
EHF44_RS05315	COG0513	Belongs to the DEAD box helicase family
EHF44_RS05340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHF44_RS05345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EHF44_RS05350	COG0594	ribonuclease P activity
EHF44_RS05355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EHF44_RS05360	COG0706	membrane insertase activity
EHF44_RS05365	COG4106	trans-aconitate 2-methyltransferase activity
EHF44_RS05375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EHF44_RS05405	COG0840	transmembrane signaling receptor activity
EHF44_RS05420	COG0583	DNA-binding transcription factor activity
EHF44_RS05455	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EHF44_RS05490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHF44_RS05495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHF44_RS05500	COG1309	transcriptional regulator
EHF44_RS05545	COG2258	MOSC domain
EHF44_RS05550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHF44_RS05555	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EHF44_RS05570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EHF44_RS05585	COG1966	Carbon starvation protein
EHF44_RS05590	COG2879	small protein
EHF44_RS05615	COG0583	DNA-binding transcription factor activity
EHF44_RS05630	COG0758	DNA mediated transformation
EHF44_RS05640	COG0242	peptide deformylase activity
EHF44_RS05645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHF44_RS05650	COG0501	Belongs to the peptidase M48B family
EHF44_RS05665	COG5000	phosphorelay sensor kinase activity
EHF44_RS05670	COG2204	response regulator
EHF44_RS05695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF44_RS05735	COG2814	Major facilitator Superfamily
EHF44_RS05740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EHF44_RS05750	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EHF44_RS05780	COG0642	Histidine kinase
EHF44_RS05790	COG2154	pterin-4-alpha-carbinolamine dehydratase
EHF44_RS05795	COG3186	Phenylalanine-4-hydroxylase
EHF44_RS05815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHF44_RS05820	COG2423	ornithine cyclodeaminase activity
EHF44_RS05825	COG3047	cAMP biosynthetic process
EHF44_RS05835	COG2217	Heavy metal translocating P-type atpase
EHF44_RS05845	COG2267	carboxylic ester hydrolase activity
EHF44_RS05850	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EHF44_RS05910	COG0583	DNA-binding transcription factor activity
EHF44_RS05925	COG0445	tRNA wobble uridine modification
EHF44_RS05930	COG0357	Ribosomal RNA small subunit methyltransferase G
EHF44_RS05935	COG1192	Involved in chromosome partitioning
EHF44_RS05950	COG0356	it plays a direct role in the translocation of protons across the membrane
EHF44_RS05960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EHF44_RS05965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EHF44_RS05970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EHF44_RS05975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EHF44_RS05980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EHF44_RS05985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EHF44_RS05995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EHF44_RS06000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EHF44_RS06005	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EHF44_RS06005	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EHF44_RS06005	COG0506	proline dehydrogenase activity
EHF44_RS06010	COG0683	leucine binding
EHF44_RS06035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EHF44_RS06040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF44_RS06045	COG1760	l-serine dehydratase
EHF44_RS06050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHF44_RS06050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHF44_RS06055	COG0509	glycine decarboxylation via glycine cleavage system
EHF44_RS06060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EHF44_RS06070	COG0210	DNA helicase
EHF44_RS06090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHF44_RS06095	COG3245	cytochrome
EHF44_RS06105	COG0277	FAD linked oxidase domain protein
EHF44_RS06120	COG0501	Belongs to the peptidase M48B family
EHF44_RS06130	COG0789	Transcriptional regulator
EHF44_RS06135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHF44_RS06145	COG2321	neutral zinc metallopeptidase
EHF44_RS06150	COG0469	pyruvate kinase activity
EHF44_RS06160	COG2084	Dehydrogenase
EHF44_RS06165	COG3622	Belongs to the hyi family
EHF44_RS06170	COG3960	tartronate-semialdehyde synthase activity
EHF44_RS06180	COG0583	DNA-binding transcription factor activity
EHF44_RS06190	COG1301	dicarboxylic acid transport
EHF44_RS06200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF44_RS06210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHF44_RS06220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EHF44_RS06230	COG1393	Belongs to the ArsC family
EHF44_RS06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF44_RS06255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EHF44_RS06260	COG0792	nuclease activity
EHF44_RS06265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHF44_RS06270	COG2823	Periplasmic or secreted lipoprotein
EHF44_RS06280	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHF44_RS06290	COG4654	Cytochrome c, class I
EHF44_RS06315	COG2010	Cytochrome c
EHF44_RS06320	COG0737	Belongs to the 5'-nucleotidase family
EHF44_RS06350	COG1280	lysine exporter protein (LysE YggA)
EHF44_RS06355	COG2818	Glycosylase
EHF44_RS06370	COG3384	dioxygenase
EHF44_RS06425	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EHF44_RS06505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHF44_RS06510	COG2151	metal-sulfur cluster biosynthetic enzyme
EHF44_RS06515	COG3396	Phenylacetate-CoA oxygenase
EHF44_RS06520	COG3460	Phenylacetate-CoA oxygenase
EHF44_RS06525	COG3396	Phenylacetate-CoA oxygenase
EHF44_RS06545	COG0700	Nucleoside recognition
EHF44_RS06595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHF44_RS06615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EHF44_RS06620	COG0081	regulation of translation
EHF44_RS06625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EHF44_RS06630	COG0222	ribosome binding
EHF44_RS06635	COG0085	RNA polymerase activity
EHF44_RS06640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EHF44_RS06650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EHF44_RS06660	COG2010	Cytochrome c
EHF44_RS06670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS06675	COG0514	ATP-dependent DNA helicase (RecQ)
EHF44_RS06680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EHF44_RS06685	COG0049	tRNA binding
EHF44_RS06690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHF44_RS06695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHF44_RS06700	COG0051	transcription antitermination factor activity, RNA binding
EHF44_RS06705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EHF44_RS06710	COG0088	Forms part of the polypeptide exit tunnel
EHF44_RS06715	COG0089	rRNA binding
EHF44_RS06720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EHF44_RS06725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EHF44_RS06730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EHF44_RS06735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EHF44_RS06740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EHF44_RS06745	COG0255	Belongs to the universal ribosomal protein uL29 family
EHF44_RS06750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EHF44_RS06755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EHF44_RS06760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EHF44_RS06765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EHF44_RS06770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHF44_RS06775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EHF44_RS06780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EHF44_RS06785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EHF44_RS06790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EHF44_RS06795	COG1841	ribosomal large subunit assembly
EHF44_RS06800	COG0200	Binds to the 23S rRNA
EHF44_RS06805	COG0201	protein transport
EHF44_RS06810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHF44_RS06815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EHF44_RS06820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EHF44_RS06825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EHF44_RS06830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EHF44_RS06835	COG0202	RNA polymerase activity
EHF44_RS06840	COG0203	ribosomal protein L17
EHF44_RS06850	COG4232	protein-disulfide reductase activity
EHF44_RS06855	COG0598	Magnesium transport protein CorA
EHF44_RS06865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EHF44_RS06875	COG1333	cytochrome c biogenesis protein
EHF44_RS06880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHF44_RS06890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EHF44_RS06895	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EHF44_RS06900	COG0019	diaminopimelate decarboxylase activity
EHF44_RS06910	COG1965	Belongs to the frataxin family
EHF44_RS06945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHF44_RS06950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EHF44_RS06955	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EHF44_RS06965	COG0067	glutamate synthase
EHF44_RS06965	COG0070	glutamate synthase
EHF44_RS06965	COG0069	glutamate synthase activity
EHF44_RS06990	COG1127	ABC transporter
EHF44_RS06995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHF44_RS07000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHF44_RS07005	COG2853	Lipoprotein
EHF44_RS07020	COG1131	(ABC) transporter
EHF44_RS07025	COG0842	Transport permease protein
EHF44_RS07035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EHF44_RS07040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EHF44_RS07045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EHF44_RS07050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHF44_RS07055	COG0131	Imidazoleglycerol-phosphate dehydratase
EHF44_RS07060	COG2095	MarC family integral membrane protein
EHF44_RS07065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EHF44_RS07070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EHF44_RS07075	COG0107	imidazoleglycerol-phosphate synthase activity
EHF44_RS07080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EHF44_RS07085	COG0140	phosphoribosyl-ATP diphosphatase activity
EHF44_RS07100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHF44_RS07105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHF44_RS07110	COG0805	protein transport
EHF44_RS07115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS07120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF44_RS07125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EHF44_RS07130	COG1970	mechanosensitive ion channel activity
EHF44_RS07135	COG0723	plastoquinol--plastocyanin reductase activity
EHF44_RS07140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EHF44_RS07145	COG2857	Cytochrome c1
EHF44_RS07150	COG0625	glutathione transferase activity
EHF44_RS07155	COG2969	positive regulation of protein catabolic process
EHF44_RS07165	COG0582	viral genome integration into host DNA
EHF44_RS07235	COG1451	nucleotide metabolic process
EHF44_RS07245	COG0488	(ABC) transporter
EHF44_RS07250	COG1408	metallophosphoesterase
EHF44_RS07290	COG0038	chloride channel
EHF44_RS07305	COG1522	sequence-specific DNA binding
EHF44_RS07315	COG1012	belongs to the aldehyde dehydrogenase family
EHF44_RS07325	COG0163	prenyltransferase activity
EHF44_RS07330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EHF44_RS07335	COG2890	protein-(glutamine-N5) methyltransferase activity
EHF44_RS07345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EHF44_RS07350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EHF44_RS07360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHF44_RS07365	COG4774	siderophore transport
EHF44_RS07385	COG0012	GTP binding
EHF44_RS07390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHF44_RS07395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHF44_RS07400	COG0604	alcohol dehydrogenase
EHF44_RS07410	COG1289	transmembrane transporter activity
EHF44_RS07415	COG1116	anion transmembrane transporter activity
EHF44_RS07425	COG1254	Belongs to the acylphosphatase family
EHF44_RS07430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHF44_RS07440	COG0134	indole-3-glycerol-phosphate synthase activity
EHF44_RS07445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHF44_RS07450	COG0512	Glutamine amidotransferase of anthranilate synthase
EHF44_RS07460	COG0546	phosphoglycolate phosphatase activity
EHF44_RS07465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EHF44_RS07470	COG2967	ApaG domain
EHF44_RS07495	COG2010	Cytochrome c
EHF44_RS07520	COG0535	radical SAM domain protein
EHF44_RS07540	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EHF44_RS07545	COG3604	Transcriptional regulator
EHF44_RS07555	COG2050	protein possibly involved in aromatic compounds catabolism
EHF44_RS07560	COG1024	Enoyl-CoA hydratase
EHF44_RS07565	COG1024	Enoyl-CoA hydratase
EHF44_RS07600	COG1473	amidohydrolase
EHF44_RS07605	COG0747	negative chemotaxis
EHF44_RS07610	COG0601	transmembrane transport
EHF44_RS07615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF44_RS07620	COG0444	Belongs to the ABC transporter superfamily
EHF44_RS07625	COG4608	Belongs to the ABC transporter superfamily
EHF44_RS07635	COG0243	molybdopterin cofactor binding
EHF44_RS07645	COG1309	transcriptional regulator
EHF44_RS07650	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS07670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS07675	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EHF44_RS07680	COG2001	Belongs to the MraZ family
EHF44_RS07685	COG0275	rRNA processing
EHF44_RS07690	COG3116	cell division
EHF44_RS07700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHF44_RS07705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EHF44_RS07710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHF44_RS07715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EHF44_RS07725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHF44_RS07730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHF44_RS07735	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHF44_RS07740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EHF44_RS07755	COG0678	peroxiredoxin activity
EHF44_RS07760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EHF44_RS07770	COG1473	amidohydrolase
EHF44_RS07780	COG0653	protein targeting
EHF44_RS07785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EHF44_RS07795	COG0494	nUDIX hydrolase
EHF44_RS07800	COG1297	OPT oligopeptide transporter protein
EHF44_RS07805	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EHF44_RS07810	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EHF44_RS07815	COG0237	dephospho-CoA kinase activity
EHF44_RS07820	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EHF44_RS07840	COG0142	geranyltranstransferase activity
EHF44_RS07845	COG3344	reverse transcriptase
EHF44_RS07850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EHF44_RS07855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EHF44_RS07860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EHF44_RS07865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EHF44_RS07880	COG0442	prolyl-tRNA aminoacylation
EHF44_RS07885	COG0741	lytic transglycosylase activity
EHF44_RS07900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EHF44_RS07905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EHF44_RS07935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHF44_RS07935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHF44_RS07950	COG3550	peptidyl-serine autophosphorylation
EHF44_RS07965	COG2974	May be involved in recombination
EHF44_RS07980	COG0656	L-ascorbic acid biosynthetic process
EHF44_RS07990	COG0583	DNA-binding transcription factor activity
EHF44_RS07995	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS08020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHF44_RS08025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EHF44_RS08035	COG2264	protein methyltransferase activity
EHF44_RS08045	COG0511	ligase activity, forming carbon-carbon bonds
EHF44_RS08050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHF44_RS08055	COG3118	belongs to the thioredoxin family
EHF44_RS08065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHF44_RS08075	COG3161	chorismate lyase activity
EHF44_RS08080	COG0557	exoribonuclease II activity
EHF44_RS08090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHF44_RS08095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHF44_RS08100	COG0598	Magnesium transport protein CorA
EHF44_RS08110	COG0284	orotidine-5'-phosphate decarboxylase activity
EHF44_RS08115	COG1058	Belongs to the CinA family
EHF44_RS08115	COG1546	Belongs to the CinA family
EHF44_RS08120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EHF44_RS08150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EHF44_RS08160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EHF44_RS08165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHF44_RS08170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHF44_RS08175	COG0583	DNA-binding transcription factor activity
EHF44_RS08180	COG0735	belongs to the Fur family
EHF44_RS08185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHF44_RS08190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EHF44_RS08195	COG0495	leucyl-tRNA aminoacylation
EHF44_RS08205	COG1466	dna polymerase III delta subunit
EHF44_RS08210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EHF44_RS08215	COG1981	membrane
EHF44_RS08260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHF44_RS08270	COG0482	sulfurtransferase activity
EHF44_RS08275	COG0625	glutathione transferase activity
EHF44_RS08315	COG2204	response regulator
EHF44_RS08320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHF44_RS08325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHF44_RS08330	COG1862	Preprotein translocase
EHF44_RS08335	COG0343	queuine tRNA-ribosyltransferase activity
EHF44_RS08340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EHF44_RS08345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHF44_RS08360	COG0783	Belongs to the Dps family
EHF44_RS08365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EHF44_RS08390	COG0386	Belongs to the glutathione peroxidase family
EHF44_RS08405	COG1346	cytolysis
EHF44_RS08410	COG1380	Effector of murein hydrolase LrgA
EHF44_RS08415	COG0247	lactate metabolic process
EHF44_RS08420	COG0277	FAD linked oxidase domain protein
EHF44_RS08425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHF44_RS08430	COG0277	FAD linked oxidase domain protein
EHF44_RS08435	COG0583	DNA-binding transcription factor activity
EHF44_RS08440	COG0277	FAD linked oxidase domain protein
EHF44_RS08445	COG2096	Adenosyltransferase
EHF44_RS08450	COG0443	Heat shock 70 kDa protein
EHF44_RS08455	COG0484	heat shock protein binding
EHF44_RS08460	COG0512	Glutamine amidotransferase of anthranilate synthase
EHF44_RS08460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHF44_RS08465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EHF44_RS08475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHF44_RS08490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHF44_RS08495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EHF44_RS08505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EHF44_RS08510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EHF44_RS08515	COG0586	Pfam SNARE associated Golgi protein
EHF44_RS08525	COG0728	peptidoglycan biosynthetic process
EHF44_RS08530	COG0268	Binds directly to 16S ribosomal RNA
EHF44_RS08540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EHF44_RS08545	COG3123	guanosine phosphorylase activity
EHF44_RS08550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EHF44_RS08555	COG1666	GTP binding
EHF44_RS08580	COG1278	Cold shock
EHF44_RS08585	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EHF44_RS08590	COG0542	response to heat
EHF44_RS08605	COG0756	dUTP diphosphatase activity
EHF44_RS08610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHF44_RS08615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EHF44_RS08620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHF44_RS08625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHF44_RS08630	COG0196	riboflavin kinase activity
EHF44_RS08635	COG0784	Response regulator, receiver
EHF44_RS08635	COG2198	Histidine kinase
EHF44_RS08635	COG2205	protein histidine kinase activity
EHF44_RS08640	COG2197	response regulator
EHF44_RS08645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EHF44_RS08650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHF44_RS08650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHF44_RS08655	COG0668	transmembrane transport
EHF44_RS08665	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EHF44_RS08675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EHF44_RS08680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EHF44_RS08685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHF44_RS08690	COG1047	Peptidyl-prolyl cis-trans
EHF44_RS08695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EHF44_RS08715	COG0411	ABC transporter
EHF44_RS08725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EHF44_RS08730	COG0543	2 iron, 2 sulfur cluster binding
EHF44_RS08730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHF44_RS08740	COG2358	TRAP transporter, solute receptor (TAXI family
EHF44_RS08745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF44_RS08755	COG2188	Transcriptional regulator
EHF44_RS08760	COG2986	histidine ammonia-lyase
EHF44_RS08765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EHF44_RS08775	COG1228	amidohydrolase
EHF44_RS08780	COG0402	S-adenosylhomocysteine deaminase activity
EHF44_RS08795	COG2985	domain, Protein
EHF44_RS08800	COG0501	Belongs to the peptidase M48B family
EHF44_RS08820	COG2084	Dehydrogenase
EHF44_RS08830	COG0583	DNA-binding transcription factor activity
EHF44_RS08835	COG0730	response to heat
EHF44_RS08840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHF44_RS08850	COG0175	sulfate reduction
EHF44_RS08855	COG0175	sulfate reduction
EHF44_RS08860	COG2895	sulfate adenylyltransferase (ATP) activity
EHF44_RS08865	COG1648	precorrin-2 dehydrogenase activity
EHF44_RS08865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHF44_RS08875	COG0795	lipopolysaccharide-transporting ATPase activity
EHF44_RS08885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHF44_RS08900	COG0129	dihydroxy-acid dehydratase activity
EHF44_RS08905	COG0583	DNA-binding transcription factor activity
EHF44_RS08910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EHF44_RS08915	COG1802	Transcriptional regulator
EHF44_RS08930	COG1024	Enoyl-CoA hydratase
EHF44_RS08935	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS08965	COG4206	TonB-dependent receptor
EHF44_RS08975	COG1120	ATPase activity
EHF44_RS08985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EHF44_RS08990	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EHF44_RS09000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHF44_RS09010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EHF44_RS09020	COG1492	cobalamin metabolic process
EHF44_RS09035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EHF44_RS09040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EHF44_RS09055	COG2911	Protein conserved in bacteria
EHF44_RS09070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHF44_RS09070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHF44_RS09075	COG2885	chlorophyll binding
EHF44_RS09075	COG3047	cAMP biosynthetic process
EHF44_RS09080	COG0489	protein tyrosine kinase activity
EHF44_RS09085	COG2032	superoxide dismutase activity
EHF44_RS09090	COG0717	Belongs to the dCTP deaminase family
EHF44_RS09100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EHF44_RS09110	COG0165	Argininosuccinate lyase
EHF44_RS09115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EHF44_RS09120	COG0181	hydroxymethylbilane synthase activity
EHF44_RS09135	COG0415	Belongs to the DNA photolyase family
EHF44_RS09145	COG1678	Uncharacterized ACR, COG1678
EHF44_RS09150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EHF44_RS09155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EHF44_RS09160	COG0540	Belongs to the ATCase OTCase family
EHF44_RS09165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EHF44_RS09195	COG2076	Multidrug Resistance protein
EHF44_RS09200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHF44_RS09205	COG4106	trans-aconitate 2-methyltransferase activity
EHF44_RS09215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHF44_RS09230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EHF44_RS09275	COG0438	transferase activity, transferring glycosyl groups
EHF44_RS09280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EHF44_RS09290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHF44_RS09310	COG0438	transferase activity, transferring glycosyl groups
EHF44_RS09320	COG0438	transferase activity, transferring glycosyl groups
EHF44_RS09325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EHF44_RS09360	COG1538	Outer membrane efflux protein
EHF44_RS09365	COG0425	Belongs to the sulfur carrier protein TusA family
EHF44_RS09365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHF44_RS09370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EHF44_RS09390	COG1968	undecaprenyl-diphosphatase activity
EHF44_RS09395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EHF44_RS09420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHF44_RS09425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EHF44_RS09430	COG0741	lytic transglycosylase activity
EHF44_RS09435	COG0436	Aminotransferase
EHF44_RS09440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHF44_RS09445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EHF44_RS09455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS09465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHF44_RS09465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHF44_RS09530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHF44_RS09535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHF44_RS09540	COG0824	Thioesterase
EHF44_RS09560	COG0823	Involved in the tonB-independent uptake of proteins
EHF44_RS09575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EHF44_RS09580	COG2391	methyltransferase activity
EHF44_RS09595	COG3447	MASE1 domain protein
EHF44_RS09595	COG5001	Diguanylate cyclase
EHF44_RS09595	COG5002	protein histidine kinase activity
EHF44_RS09615	COG0450	alkyl hydroperoxide reductase
EHF44_RS09630	COG3483	tryptophan 2,3-dioxygenase activity
EHF44_RS09640	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EHF44_RS09645	COG1522	sequence-specific DNA binding
EHF44_RS09660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHF44_RS09665	COG0259	pyridoxamine-phosphate oxidase activity
EHF44_RS09675	COG2982	Protein involved in outer membrane biogenesis
EHF44_RS09680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EHF44_RS09700	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS09710	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EHF44_RS09725	COG4681	YaeQ
EHF44_RS09750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHF44_RS09755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS09770	COG0786	glutamate:sodium symporter activity
EHF44_RS09780	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS09800	COG3263	regulation of cellular component size
EHF44_RS09815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS09820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHF44_RS09835	COG0477	Major facilitator Superfamily
EHF44_RS09840	COG0235	Class ii aldolase
EHF44_RS09845	COG1942	4-Oxalocrotonate Tautomerase
EHF44_RS09855	COG2816	NAD+ diphosphatase activity
EHF44_RS09860	COG0425	Belongs to the sulfur carrier protein TusA family
EHF44_RS09870	COG0525	valine-tRNA ligase activity
EHF44_RS09875	COG0210	DNA helicase
EHF44_RS09885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EHF44_RS09895	COG1611	Belongs to the LOG family
EHF44_RS09900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHF44_RS09900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHF44_RS09905	COG1252	NADH dehydrogenase
EHF44_RS09910	COG0412	Dienelactone hydrolase
EHF44_RS09935	COG1722	exodeoxyribonuclease VII activity
EHF44_RS09940	COG0142	geranyltranstransferase activity
EHF44_RS09945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EHF44_RS09950	COG1469	GTP cyclohydrolase I activity
EHF44_RS09960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHF44_RS09965	COG2081	HI0933 family
EHF44_RS09970	COG1610	YqeY-like protein
EHF44_RS10015	COG4263	nitrous-oxide reductase activity
EHF44_RS10025	COG1349	DNA-binding transcription factor activity
EHF44_RS10030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EHF44_RS10035	COG3395	kinase activity
EHF44_RS10050	COG1414	Transcriptional regulator
EHF44_RS10070	COG0513	Belongs to the DEAD box helicase family
EHF44_RS10075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHF44_RS10080	COG0583	DNA-binding transcription factor activity
EHF44_RS10085	COG1741	Belongs to the pirin family
EHF44_RS10090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EHF44_RS10100	COG1162	GTPase activity
EHF44_RS10105	COG0501	Belongs to the peptidase M48B family
EHF44_RS10110	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EHF44_RS10120	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHF44_RS10125	COG3028	Belongs to the UPF0307 family
EHF44_RS10130	COG0312	modulator of DNA gyrase
EHF44_RS10190	COG1204	response to ionizing radiation
EHF44_RS10205	COG2916	Histone family protein nucleoid-structuring protein H-NS
EHF44_RS10220	COG0494	nUDIX hydrolase
EHF44_RS10240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EHF44_RS10270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EHF44_RS10285	COG4974	Belongs to the 'phage' integrase family
EHF44_RS10295	COG0861	Integral membrane protein TerC family
EHF44_RS10300	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EHF44_RS10305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EHF44_RS10310	COG0513	Belongs to the DEAD box helicase family
EHF44_RS10340	COG0515	serine threonine protein kinase
EHF44_RS10345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EHF44_RS10345	COG0515	serine threonine protein kinase
EHF44_RS10380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHF44_RS10390	COG2204	response regulator
EHF44_RS10415	COG0582	viral genome integration into host DNA
EHF44_RS10445	COG0419	ATPase involved in DNA repair
EHF44_RS10450	COG1674	ftsk spoiiie
EHF44_RS10470	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
EHF44_RS10480	COG1598	PFAM Uncharacterised protein family UPF0150
EHF44_RS10485	COG1724	mRNA binding
EHF44_RS10500	COG5410	chromosome segregation
EHF44_RS10620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHF44_RS10620	COG2755	lipolytic protein G-D-S-L family
EHF44_RS10625	COG3179	chitinase
EHF44_RS10760	COG1696	Membrane protein involved in D-alanine export
EHF44_RS10795	COG0488	(ABC) transporter
EHF44_RS10800	COG2271	Major facilitator Superfamily
EHF44_RS10830	COG0625	glutathione transferase activity
EHF44_RS10835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS10845	COG0697	spore germination
EHF44_RS10855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHF44_RS10870	COG0326	Molecular chaperone. Has ATPase activity
EHF44_RS10900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EHF44_RS10910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EHF44_RS10925	COG0039	L-malate dehydrogenase activity
EHF44_RS10930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS10940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EHF44_RS10945	COG1053	succinate dehydrogenase
EHF44_RS10950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHF44_RS10955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EHF44_RS10960	COG0372	Belongs to the citrate synthase family
EHF44_RS10990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHF44_RS11000	COG0066	3-isopropylmalate dehydratase activity
EHF44_RS11005	COG0473	3-isopropylmalate dehydrogenase activity
EHF44_RS11010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHF44_RS11020	COG0101	tRNA pseudouridine synthase activity
EHF44_RS11025	COG0135	phosphoribosylanthranilate isomerase activity
EHF44_RS11030	COG0133	tryptophan synthase activity
EHF44_RS11040	COG0159	tryptophan synthase activity
EHF44_RS11045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EHF44_RS11050	COG0285	dihydrofolate synthase activity
EHF44_RS11080	COG1131	(ABC) transporter
EHF44_RS11085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EHF44_RS11105	COG0492	ferredoxin-NADP+ reductase activity
EHF44_RS11110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EHF44_RS11120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EHF44_RS11125	COG1556	Lactate utilization protein
EHF44_RS11135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHF44_RS11150	COG0303	'Molybdopterin
EHF44_RS11155	COG0746	molybdenum cofactor guanylyltransferase activity
EHF44_RS11160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EHF44_RS11165	COG1530	ribonuclease E activity
EHF44_RS11195	COG0424	maF-like protein
EHF44_RS11205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EHF44_RS11210	COG0416	fatty acid biosynthetic process
EHF44_RS11215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHF44_RS11220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EHF44_RS11230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHF44_RS11235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHF44_RS11240	COG1595	DNA-templated transcription, initiation
EHF44_RS11255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF44_RS11260	COG0481	GTPase activity
EHF44_RS11265	COG0681	Belongs to the peptidase S26 family
EHF44_RS11275	COG0571	ribonuclease III activity
EHF44_RS11280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EHF44_RS11285	COG1381	Involved in DNA repair and RecF pathway recombination
EHF44_RS11290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EHF44_RS11295	COG0736	holo-[acyl-carrier-protein] synthase activity
EHF44_RS11300	COG1472	Belongs to the glycosyl hydrolase 3 family
EHF44_RS11305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHF44_RS11315	COG0322	excinuclease ABC activity
EHF44_RS11320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHF44_RS11340	COG4651	solute:proton antiporter activity
EHF44_RS11340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHF44_RS11345	COG0583	DNA-binding transcription factor activity
EHF44_RS11350	COG2855	membrane
EHF44_RS11370	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EHF44_RS11395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EHF44_RS11400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EHF44_RS11415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHF44_RS11420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHF44_RS11475	COG2194	sulfuric ester hydrolase activity
EHF44_RS11480	COG1215	transferase activity, transferring glycosyl groups
EHF44_RS11500	COG0457	Tetratricopeptide repeat
EHF44_RS11505	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EHF44_RS11510	COG1215	transferase activity, transferring glycosyl groups
EHF44_RS11525	COG5001	Diguanylate cyclase
EHF44_RS11525	COG3300	MHYT domain
EHF44_RS11530	COG2199	diguanylate cyclase activity
EHF44_RS11560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHF44_RS11580	COG3842	ATPase activity
EHF44_RS11585	COG3842	ATPase activity
EHF44_RS11595	COG0395	ABC-type sugar transport system, permease component
EHF44_RS11620	COG1335	isochorismatase
EHF44_RS11640	COG1116	anion transmembrane transporter activity
EHF44_RS11660	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS11690	COG0745	RESPONSE REGULATOR receiver
EHF44_RS11720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHF44_RS11725	COG0328	RNA-DNA hybrid ribonuclease activity
EHF44_RS11730	COG2226	methyltransferase
EHF44_RS11735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF44_RS11740	COG0741	lytic transglycosylase activity
EHF44_RS11740	COG1388	LysM domain
EHF44_RS11745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHF44_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS11760	COG1024	Enoyl-CoA hydratase
EHF44_RS11785	COG0505	Belongs to the CarA family
EHF44_RS11795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EHF44_RS11800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHF44_RS11810	COG1534	Rna-binding protein
EHF44_RS11815	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EHF44_RS11820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHF44_RS11825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EHF44_RS11830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHF44_RS11835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHF44_RS11840	COG0573	inorganic phosphate transmembrane transporter activity
EHF44_RS11845	COG0581	inorganic phosphate transmembrane transporter activity
EHF44_RS11850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHF44_RS11875	COG0248	Ppx GppA phosphatase
EHF44_RS11885	COG2062	phosphohistidine phosphatase, SixA
EHF44_RS11890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHF44_RS11905	COG2226	methyltransferase
EHF44_RS11920	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EHF44_RS11940	COG4174	ABC transporter (Permease)
EHF44_RS11945	COG4239	(ABC) transporter, permease
EHF44_RS11950	COG4172	Belongs to the ABC transporter superfamily
EHF44_RS11955	COG0791	NLP P60 protein
EHF44_RS11960	COG1752	Esterase of the alpha-beta hydrolase superfamily
EHF44_RS11965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHF44_RS12000	COG0534	Mate efflux family protein
EHF44_RS12010	COG0254	rRNA binding
EHF44_RS12020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EHF44_RS12040	COG1074	ATP-dependent DNA helicase activity
EHF44_RS12050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHF44_RS12060	COG1620	l-lactate permease
EHF44_RS12065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EHF44_RS12070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EHF44_RS12075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EHF44_RS12080	COG0583	DNA-binding transcription factor activity
EHF44_RS12085	COG2801	Transposase and inactivated derivatives
EHF44_RS12085	COG3415	Transposase
EHF44_RS12100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS12105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHF44_RS12115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHF44_RS12125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF44_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS12130	COG0604	alcohol dehydrogenase
EHF44_RS12130	COG3321	synthase
EHF44_RS12135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EHF44_RS12140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EHF44_RS12165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHF44_RS12170	COG0670	Belongs to the BI1 family
EHF44_RS12175	COG0105	UTP biosynthetic process
EHF44_RS12180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EHF44_RS12195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EHF44_RS12200	COG0124	histidyl-tRNA synthetase
EHF44_RS12215	COG1160	GTP binding
EHF44_RS12220	COG1923	regulation of RNA biosynthetic process
EHF44_RS12225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EHF44_RS12230	COG0330	HflC and HflK could
EHF44_RS12235	COG0330	HflC and HflK could
EHF44_RS12240	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EHF44_RS12245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHF44_RS12250	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EHF44_RS12255	COG2910	NAD(P)H-binding
EHF44_RS12270	COG0557	exoribonuclease II activity
EHF44_RS12275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHF44_RS12280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EHF44_RS12285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHF44_RS12290	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EHF44_RS12295	COG2197	response regulator
EHF44_RS12300	COG3850	Histidine kinase
EHF44_RS12310	COG2070	2-Nitropropane dioxygenase
EHF44_RS12315	COG0288	reversible hydration of carbon dioxide
EHF44_RS12320	COG2181	nitrate reductase activity
EHF44_RS12325	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EHF44_RS12330	COG1140	nitrate reductase beta subunit
EHF44_RS12335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EHF44_RS12340	COG2223	nitrite transmembrane transporter activity
EHF44_RS12350	COG2977	Belongs to the P-Pant transferase superfamily
EHF44_RS12355	COG1021	2,3-dihydroxybenzoate-AMP ligase
EHF44_RS12375	COG3433	isochorismatase activity
EHF44_RS12375	COG2226	methyltransferase
EHF44_RS12375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHF44_RS12380	COG1132	(ABC) transporter
EHF44_RS12380	COG2375	cellular response to nickel ion
EHF44_RS12385	COG2375	cellular response to nickel ion
EHF44_RS12385	COG1132	(ABC) transporter
EHF44_RS12390	COG4771	TonB-dependent receptor
EHF44_RS12410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EHF44_RS12415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHF44_RS12415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHF44_RS12420	COG1643	Atp-dependent helicase
EHF44_RS12455	COG0174	glutamine synthetase
EHF44_RS12465	COG3852	Histidine kinase
EHF44_RS12485	COG1175	transmembrane transport
EHF44_RS12490	COG0395	ABC-type sugar transport system, permease component
EHF44_RS12495	COG3842	ATPase activity
EHF44_RS12500	COG0584	glycerophosphoryl diester phosphodiesterase
EHF44_RS12505	COG0567	Dehydrogenase, E1 component
EHF44_RS12510	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHF44_RS12515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF44_RS12520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EHF44_RS12535	COG3278	Belongs to the heme-copper respiratory oxidase family
EHF44_RS12555	COG0348	domain, Protein
EHF44_RS12570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHF44_RS12580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EHF44_RS12585	COG1187	pseudouridine synthase activity
EHF44_RS12590	COG0779	Required for maturation of 30S ribosomal subunits
EHF44_RS12595	COG0195	Participates in both transcription termination and antitermination
EHF44_RS12595	COG2251	uridine kinase activity
EHF44_RS12600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EHF44_RS12605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EHF44_RS12610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EHF44_RS12615	COG2814	Major facilitator Superfamily
EHF44_RS12620	COG1566	PFAM secretion protein HlyD family protein
EHF44_RS12645	COG0840	transmembrane signaling receptor activity
EHF44_RS12650	COG1024	Enoyl-CoA hydratase
EHF44_RS12655	COG0431	NADPH-dependent FMN reductase
EHF44_RS12660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHF44_RS12680	COG0662	Cupin 2, conserved barrel domain protein
EHF44_RS12685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EHF44_RS12690	COG0252	asparaginase activity
EHF44_RS12695	COG0360	Binds together with S18 to 16S ribosomal RNA
EHF44_RS12705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EHF44_RS12710	COG0359	binds to the 23S rRNA
EHF44_RS12715	COG0305	Participates in initiation and elongation during chromosome replication
EHF44_RS12725	COG0306	phosphate transporter
EHF44_RS12735	COG0791	NLP P60 protein
EHF44_RS12745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EHF44_RS12750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EHF44_RS12760	COG3344	reverse transcriptase
EHF44_RS12765	COG0436	Aminotransferase
EHF44_RS12780	COG0303	'Molybdopterin
EHF44_RS12790	COG0314	molybdopterin synthase activity
EHF44_RS12795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHF44_RS12805	COG0542	response to heat
EHF44_RS12815	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EHF44_RS12820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHF44_RS12825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHF44_RS12830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF44_RS12835	COG1116	anion transmembrane transporter activity
EHF44_RS12850	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EHF44_RS12855	COG4208	sulfate ABC transporter
EHF44_RS12860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EHF44_RS12865	COG0583	DNA-binding transcription factor activity
EHF44_RS12870	COG2972	Histidine kinase
EHF44_RS12880	COG2224	Isocitrate lyase
EHF44_RS12885	COG0589	response to stress
EHF44_RS12890	COG0583	DNA-binding transcription factor activity
EHF44_RS12900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EHF44_RS12910	COG2814	Major facilitator Superfamily
EHF44_RS12925	COG1214	PFAM Peptidase M22, glycoprotease
EHF44_RS12935	COG1573	uracil-dna glycosylase
EHF44_RS12945	COG0477	Major facilitator Superfamily
EHF44_RS12950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHF44_RS12960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EHF44_RS12965	COG0488	(ABC) transporter
EHF44_RS12975	COG1446	asparaginase
EHF44_RS12980	COG4172	Belongs to the ABC transporter superfamily
EHF44_RS12985	COG0747	negative chemotaxis
EHF44_RS12995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF44_RS13020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EHF44_RS13030	COG0246	Mannitol dehydrogenase
EHF44_RS13035	COG4948	Mandelate Racemase Muconate Lactonizing
EHF44_RS13040	COG2721	sulfolactate sulfo-lyase activity
EHF44_RS13045	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS13050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EHF44_RS13055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EHF44_RS13060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EHF44_RS13065	COG1063	alcohol dehydrogenase
EHF44_RS13080	COG2890	protein-(glutamine-N5) methyltransferase activity
EHF44_RS13085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF44_RS13090	COG1393	Belongs to the ArsC family
EHF44_RS13100	COG2171	N-acyltransferase activity
EHF44_RS13125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHF44_RS13130	COG0242	peptide deformylase activity
EHF44_RS13135	COG1187	pseudouridine synthase activity
EHF44_RS13140	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EHF44_RS13150	COG0052	Belongs to the universal ribosomal protein uS2 family
EHF44_RS13155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EHF44_RS13160	COG0528	UMP kinase activity
EHF44_RS13165	COG0233	cytoplasmic translational termination
EHF44_RS13170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHF44_RS13175	COG0575	Belongs to the CDS family
EHF44_RS13180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EHF44_RS13185	COG0750	zinc metalloprotease
EHF44_RS13200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHF44_RS13205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHF44_RS13210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHF44_RS13215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHF44_RS13220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EHF44_RS13225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHF44_RS13230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EHF44_RS13245	COG0330	HflC and HflK could
EHF44_RS13250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EHF44_RS13255	COG2867	negative regulation of translational initiation
EHF44_RS13260	COG2914	Belongs to the UPF0125 (RnfH) family
EHF44_RS13285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EHF44_RS13285	COG0519	Catalyzes the synthesis of GMP from XMP
EHF44_RS13290	COG3706	GGDEF domain
EHF44_RS13310	COG0602	queuosine metabolic process
EHF44_RS13315	COG0720	synthase
EHF44_RS13325	COG1619	proteins homologs of microcin C7 resistance protein MccF
EHF44_RS13330	COG0488	(ABC) transporter
EHF44_RS13335	COG0745	RESPONSE REGULATOR receiver
EHF44_RS13340	COG2205	protein histidine kinase activity
EHF44_RS13345	COG4452	Inner membrane protein CreD
EHF44_RS13365	COG0505	Belongs to the CarA family
EHF44_RS13370	COG2258	MOSC domain
EHF44_RS13410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EHF44_RS13415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EHF44_RS13420	COG0583	DNA-binding transcription factor activity
EHF44_RS13435	COG1674	ftsk spoiiie
EHF44_RS13455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EHF44_RS13475	COG2207	Transcriptional regulator
EHF44_RS13480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EHF44_RS13490	COG2200	EAL domain
EHF44_RS13495	COG1914	H( )-stimulated, divalent metal cation uptake system
EHF44_RS13515	COG3791	Glutathione-dependent formaldehyde-activating
EHF44_RS13530	COG2084	Dehydrogenase
EHF44_RS13535	COG3836	Belongs to the HpcH HpaI aldolase family
EHF44_RS13540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EHF44_RS13550	COG0028	Belongs to the TPP enzyme family
EHF44_RS13560	COG0583	DNA-binding transcription factor activity
EHF44_RS13565	COG5383	Protein conserved in bacteria
EHF44_RS13605	COG0628	permease
EHF44_RS13620	COG0417	DNA replication proofreading
EHF44_RS13650	COG2204	response regulator
EHF44_RS13655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHF44_RS13660	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EHF44_RS13665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS13685	COG2010	Cytochrome c
EHF44_RS13685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF44_RS13695	COG1024	Enoyl-CoA hydratase
EHF44_RS13715	COG3833	ABC-type maltose transport systems, permease component
EHF44_RS13730	COG3842	ATPase activity
EHF44_RS13745	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS13815	COG1609	Transcriptional regulator
EHF44_RS13850	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS13865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS13870	COG1024	Enoyl-CoA hydratase
EHF44_RS13880	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS13885	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS13890	COG2207	Transcriptional regulator
EHF44_RS13915	COG1609	Transcriptional regulator
EHF44_RS13930	COG0277	FAD linked oxidase domain protein
EHF44_RS13935	COG0583	DNA-binding transcription factor activity
EHF44_RS13940	COG0277	FAD linked oxidase domain protein
EHF44_RS13945	COG0277	FAD linked oxidase domain protein
EHF44_RS13950	COG0247	lactate metabolic process
EHF44_RS13980	COG3959	Transketolase, thiamine diphosphate binding domain
EHF44_RS13990	COG0477	Major facilitator Superfamily
EHF44_RS14025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHF44_RS14070	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS14080	COG1733	regulation of RNA biosynthetic process
EHF44_RS14085	COG1686	Belongs to the peptidase S11 family
EHF44_RS14095	COG0583	DNA-binding transcription factor activity
EHF44_RS14145	COG0251	oxidation-reduction process
EHF44_RS14175	COG1484	DNA-dependent DNA replication
EHF44_RS14180	COG4584	PFAM Integrase catalytic
EHF44_RS14205	COG1522	sequence-specific DNA binding
EHF44_RS14210	COG2423	ornithine cyclodeaminase activity
EHF44_RS14230	COG0038	chloride channel
EHF44_RS14235	COG1414	Transcriptional regulator
EHF44_RS14245	COG0028	Belongs to the TPP enzyme family
EHF44_RS14250	COG2188	Transcriptional regulator
EHF44_RS14255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EHF44_RS14260	COG0477	Major facilitator Superfamily
EHF44_RS14335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHF44_RS14340	COG0456	acetyltransferase
EHF44_RS14370	COG2186	Transcriptional regulator
EHF44_RS14380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHF44_RS14395	COG1136	(ABC) transporter
EHF44_RS14395	COG0577	efflux transmembrane transporter activity
EHF44_RS14400	COG0583	DNA-binding transcription factor activity
EHF44_RS14455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EHF44_RS14465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHF44_RS14470	COG1902	pentaerythritol trinitrate reductase activity
EHF44_RS14480	COG2205	protein histidine kinase activity
EHF44_RS14495	COG1201	RNA secondary structure unwinding
EHF44_RS14500	COG1793	dna ligase
EHF44_RS14505	COG1793	dna ligase
EHF44_RS14505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EHF44_RS14515	COG1366	Belongs to the anti-sigma-factor antagonist family
EHF44_RS14520	COG1366	Belongs to the anti-sigma-factor antagonist family
EHF44_RS14525	COG2172	sigma factor antagonist activity
EHF44_RS14535	COG0784	Response regulator, receiver
EHF44_RS14535	COG2205	protein histidine kinase activity
EHF44_RS14535	COG5002	protein histidine kinase activity
EHF44_RS14540	COG0784	Response regulator, receiver
EHF44_RS14540	COG5002	protein histidine kinase activity
EHF44_RS14570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EHF44_RS14575	COG0668	transmembrane transport
EHF44_RS14590	COG1999	signal sequence binding
EHF44_RS14595	COG2010	Cytochrome c
EHF44_RS14610	COG0484	heat shock protein binding
EHF44_RS14620	COG0084	hydrolase, TatD family'
EHF44_RS14625	COG1247	-acetyltransferase
EHF44_RS14635	COG0470	DNA polymerase III
EHF44_RS14640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHF44_RS14645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EHF44_RS14665	COG0372	Belongs to the citrate synthase family
EHF44_RS14670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHF44_RS14675	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHF44_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS14695	COG2186	Transcriptional regulator
EHF44_RS14700	COG2084	Dehydrogenase
EHF44_RS14705	COG3395	kinase activity
EHF44_RS14710	COG0235	Class ii aldolase
EHF44_RS14715	COG2271	Major facilitator Superfamily
EHF44_RS14720	COG3622	Belongs to the hyi family
EHF44_RS14725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF44_RS14740	COG0657	acetylesterase activity
EHF44_RS14750	COG0596	Alpha beta hydrolase
EHF44_RS14770	COG2130	NADP-dependent
EHF44_RS14785	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS14790	COG0183	Belongs to the thiolase family
EHF44_RS14795	COG1335	isochorismatase
EHF44_RS14800	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHF44_RS14800	COG1024	Enoyl-CoA hydratase
EHF44_RS14805	COG0833	amino acid
EHF44_RS14820	COG0411	ABC transporter
EHF44_RS14840	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS14845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EHF44_RS14850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHF44_RS14855	COG2917	probably involved in intracellular septation
EHF44_RS14860	COG0271	Belongs to the BolA IbaG family
EHF44_RS14865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHF44_RS14880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHF44_RS14880	COG0047	phosphoribosylformylglycinamidine synthase activity
EHF44_RS14905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EHF44_RS14905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EHF44_RS14915	COG0166	Belongs to the GPI family
EHF44_RS14920	COG4181	ATPase activity
EHF44_RS14930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHF44_RS14945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EHF44_RS14950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EHF44_RS14955	COG0740	serine-type endopeptidase activity
EHF44_RS14960	COG0544	peptidyl-prolyl cis-trans isomerase activity
EHF44_RS14965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHF44_RS14965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHF44_RS14970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EHF44_RS14990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EHF44_RS15005	COG1215	transferase activity, transferring glycosyl groups
EHF44_RS15105	COG0747	negative chemotaxis
EHF44_RS15110	COG0601	transmembrane transport
EHF44_RS15115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF44_RS15120	COG4608	Belongs to the ABC transporter superfamily
EHF44_RS15125	COG0444	Belongs to the ABC transporter superfamily
EHF44_RS15130	COG0154	amidase activity
EHF44_RS15180	COG0450	alkyl hydroperoxide reductase
EHF44_RS15185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHF44_RS15195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EHF44_RS15200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHF44_RS15205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EHF44_RS15215	COG0560	Phosphoserine phosphatase
EHF44_RS15235	COG0626	cystathionine gamma-synthase activity
EHF44_RS15245	COG0183	Belongs to the thiolase family
EHF44_RS15250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHF44_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS15265	COG0183	Belongs to the thiolase family
EHF44_RS15270	COG3243	poly(R)-hydroxyalkanoic acid synthase
EHF44_RS15285	COG0564	pseudouridine synthase activity
EHF44_RS15325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHF44_RS15335	COG1199	ATP-dependent helicase activity
EHF44_RS15350	COG2183	response to ionizing radiation
EHF44_RS15355	COG3158	transport of potassium into the cell
EHF44_RS15365	COG0411	ABC transporter
EHF44_RS15435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EHF44_RS15445	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EHF44_RS15450	COG0167	dihydroorotate dehydrogenase activity
EHF44_RS15485	COG1414	Transcriptional regulator
EHF44_RS15500	COG0824	Thioesterase
EHF44_RS15505	COG0123	including yeast histone deacetylase and acetoin utilization protein
EHF44_RS15515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF44_RS15525	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHF44_RS15530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EHF44_RS15540	COG4566	intracellular signal transduction
EHF44_RS15550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHF44_RS15555	COG0339	signal peptide processing
EHF44_RS15600	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS15615	COG2902	Dehydrogenase
EHF44_RS15640	COG5002	protein histidine kinase activity
EHF44_RS15645	COG0745	RESPONSE REGULATOR receiver
EHF44_RS15650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHF44_RS15660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHF44_RS15775	COG0776	regulation of translation
EHF44_RS15780	COG0072	phenylalanine-tRNA ligase activity
EHF44_RS15780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHF44_RS15785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EHF44_RS15790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EHF44_RS15795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EHF44_RS15800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EHF44_RS15805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHF44_RS15815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHF44_RS15820	COG0251	oxidation-reduction process
EHF44_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS15870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EHF44_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS15900	COG2186	Transcriptional regulator
EHF44_RS15905	COG0579	oxidoreductase
EHF44_RS15910	COG2814	Major facilitator Superfamily
EHF44_RS15915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EHF44_RS15940	COG2267	carboxylic ester hydrolase activity
EHF44_RS15965	COG0277	FAD linked oxidase domain protein
EHF44_RS15980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS15985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHF44_RS15990	COG0243	molybdopterin cofactor binding
EHF44_RS16000	COG1301	dicarboxylic acid transport
EHF44_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS16015	COG2271	Major facilitator Superfamily
EHF44_RS16025	COG3038	cytochrome b561
EHF44_RS16035	COG4221	oxidoreductase activity
EHF44_RS16045	COG1858	cytochrome C peroxidase
EHF44_RS16210	COG0662	Cupin 2, conserved barrel domain protein
EHF44_RS16210	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EHF44_RS16245	COG1864	DNA RNA non-specific endonuclease
EHF44_RS16245	COG3591	Belongs to the peptidase S1B family
EHF44_RS16255	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS16260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS16265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHF44_RS16270	COG0583	DNA-binding transcription factor activity
EHF44_RS16275	COG4771	TonB-dependent receptor
EHF44_RS16285	COG3720	iron ion transport
EHF44_RS16290	COG4558	Periplasmic binding protein
EHF44_RS16295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHF44_RS16300	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHF44_RS16505	COG3210	domain, Protein
EHF44_RS16515	COG2831	hemolysin activation secretion protein
EHF44_RS16520	COG3210	domain, Protein
EHF44_RS16520	COG3064	Membrane
EHF44_RS16520	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
EHF44_RS16530	COG0527	aspartate kinase activity
EHF44_RS16535	COG0037	tRNA processing
EHF44_RS16540	COG0825	malonyl-CoA metabolic process
EHF44_RS16545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EHF44_RS16550	COG0215	cysteine-tRNA ligase activity
EHF44_RS16560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHF44_RS16570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHF44_RS16575	COG1045	serine acetyltransferase
EHF44_RS16585	COG0483	inositol monophosphate 1-phosphatase activity
EHF44_RS16825	COG1598	PFAM Uncharacterised protein family UPF0150
EHF44_RS16970	COG3617	BRO family, N-terminal domain
EHF44_RS17015	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EHF44_RS17030	COG2850	peptidyl-arginine hydroxylation
EHF44_RS17040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EHF44_RS17045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EHF44_RS17050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHF44_RS17060	COG1994	Peptidase M50
EHF44_RS17065	COG0009	L-threonylcarbamoyladenylate synthase
EHF44_RS17070	COG0613	PHP domain protein
EHF44_RS17075	COG0492	ferredoxin-NADP+ reductase activity
EHF44_RS17080	COG2267	carboxylic ester hydrolase activity
EHF44_RS17085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHF44_RS17090	COG2833	Protein of unknown function (DUF455)
EHF44_RS17100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EHF44_RS17110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EHF44_RS17115	COG0148	phosphopyruvate hydratase activity
EHF44_RS17125	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EHF44_RS17130	COG0504	CTP synthase activity
EHF44_RS17155	COG2308	Evidence 4 Homologs of previously reported genes of
EHF44_RS17160	COG3265	gluconokinase activity
EHF44_RS17170	COG1737	Transcriptional regulator
EHF44_RS17170	COG0837	glucose binding
EHF44_RS17180	COG0084	hydrolase, TatD family'
EHF44_RS17185	COG1136	(ABC) transporter
EHF44_RS17200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EHF44_RS17205	COG4942	peptidase
EHF44_RS17215	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS17220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHF44_RS17230	COG2975	iron-sulfur cluster assembly
EHF44_RS17240	COG0443	Heat shock 70 kDa protein
EHF44_RS17245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EHF44_RS17250	COG0316	Belongs to the HesB IscA family
EHF44_RS17255	COG0822	iron-sulfur transferase activity
EHF44_RS17260	COG1104	cysteine desulfurase activity
EHF44_RS17280	COG0556	nucleotide-excision repair
EHF44_RS17295	COG1309	transcriptional regulator
EHF44_RS17300	COG2878	Part of a membrane complex involved in electron transport
EHF44_RS17305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHF44_RS17320	COG2267	carboxylic ester hydrolase activity
EHF44_RS17330	COG0778	Nitroreductase
EHF44_RS17355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHF44_RS17365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EHF44_RS17370	COG1420	regulation of RNA biosynthetic process
EHF44_RS17375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EHF44_RS17380	COG0497	DNA recombination
EHF44_RS17390	COG1404	Belongs to the peptidase S8 family
EHF44_RS17400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EHF44_RS17410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHF44_RS17415	COG0312	modulator of DNA gyrase
EHF44_RS17430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHF44_RS17445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHF44_RS17460	COG0583	DNA-binding transcription factor activity
EHF44_RS17465	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS17480	COG2866	Carboxypeptidase
EHF44_RS17485	COG3022	response to hydroperoxide
EHF44_RS17495	COG0436	Aminotransferase
EHF44_RS17500	COG0625	glutathione transferase activity
EHF44_RS17505	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHF44_RS17510	COG1024	Enoyl-CoA hydratase
EHF44_RS17520	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS17525	COG0405	Gamma-glutamyltransferase
EHF44_RS17540	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS17545	COG0625	glutathione transferase activity
EHF44_RS17555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EHF44_RS17560	COG0830	nickel cation binding
EHF44_RS17565	COG2852	Protein conserved in bacteria
EHF44_RS17570	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EHF44_RS17575	COG0804	urea catabolic process
EHF44_RS17580	COG0832	Belongs to the urease beta subunit family
EHF44_RS17590	COG0831	urea catabolic process
EHF44_RS17595	COG0829	nickel cation binding
EHF44_RS17625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EHF44_RS17640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHF44_RS17660	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS17690	COG1007	ATP synthesis coupled electron transport
EHF44_RS17705	COG0713	ATP synthesis coupled electron transport
EHF44_RS17715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF44_RS17720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EHF44_RS17725	COG1034	ATP synthesis coupled electron transport
EHF44_RS17740	COG0649	NAD binding
EHF44_RS17745	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF44_RS17750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF44_RS17755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF44_RS17770	COG0149	triose-phosphate isomerase activity
EHF44_RS17775	COG0604	alcohol dehydrogenase
EHF44_RS17775	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS17775	COG3321	synthase
EHF44_RS17780	COG1185	polyribonucleotide nucleotidyltransferase activity
EHF44_RS17785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EHF44_RS17790	COG0683	leucine binding
EHF44_RS17800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHF44_RS17805	COG1652	LysM domain
EHF44_RS17810	COG1183	phosphatidylcholine synthase activity
EHF44_RS17815	COG0688	phosphatidylethanolamine metabolic process
EHF44_RS17820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EHF44_RS17825	COG0440	acetolactate synthase activity
EHF44_RS17830	COG0028	Belongs to the TPP enzyme family
EHF44_RS17865	COG0438	transferase activity, transferring glycosyl groups
EHF44_RS17895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EHF44_RS17915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF44_RS17925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHF44_RS17930	COG0402	S-adenosylhomocysteine deaminase activity
EHF44_RS17940	COG2119	membrane
EHF44_RS17950	COG2351	hydroxyisourate hydrolase activity
EHF44_RS17960	COG2233	PERMEase
EHF44_RS17970	COG3195	allantoin biosynthetic process
EHF44_RS17970	COG3648	Uricase
EHF44_RS17985	COG0281	malic enzyme
EHF44_RS17985	COG0280	phosphate acetyltransferase
EHF44_RS17995	COG0308	aminopeptidase N
EHF44_RS18000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EHF44_RS18020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EHF44_RS18030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF44_RS18065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EHF44_RS18075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS18135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHF44_RS18140	COG1758	RNA polymerase activity
EHF44_RS18145	COG0194	GDP metabolic process
EHF44_RS18150	COG1561	YicC-like family, N-terminal region
EHF44_RS18170	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EHF44_RS18175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EHF44_RS18180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHF44_RS18220	COG2186	Transcriptional regulator
EHF44_RS18250	COG1741	Belongs to the pirin family
EHF44_RS18255	COG3845	ABC transporter
EHF44_RS18260	COG4603	Belongs to the binding-protein-dependent transport system permease family
EHF44_RS18285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHF44_RS18290	COG4771	TonB-dependent receptor
EHF44_RS18320	COG0402	S-adenosylhomocysteine deaminase activity
EHF44_RS18325	COG1079	Belongs to the binding-protein-dependent transport system permease family
EHF44_RS18330	COG4603	Belongs to the binding-protein-dependent transport system permease family
EHF44_RS18335	COG3845	ABC transporter
EHF44_RS18345	COG1309	transcriptional regulator
EHF44_RS18350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EHF44_RS18390	COG2076	Multidrug Resistance protein
EHF44_RS18410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF44_RS18410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHF44_RS18415	COG0726	polysaccharide deacetylase
EHF44_RS18475	COG1063	alcohol dehydrogenase
EHF44_RS18485	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EHF44_RS18495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHF44_RS18510	COG4774	siderophore transport
EHF44_RS18535	COG0657	acetylesterase activity
EHF44_RS18560	COG0840	transmembrane signaling receptor activity
EHF44_RS18570	COG1657	PFAM Prenyltransferase squalene oxidase
EHF44_RS18580	COG1595	DNA-templated transcription, initiation
EHF44_RS18585	COG3712	iron ion homeostasis
EHF44_RS18605	COG3550	peptidyl-serine autophosphorylation
EHF44_RS18615	COG1414	Transcriptional regulator
EHF44_RS18630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHF44_RS18635	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS18645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHF44_RS18695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHF44_RS18700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHF44_RS18705	COG0204	Acyl-transferase
EHF44_RS18720	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EHF44_RS18735	COG0596	Alpha beta hydrolase
EHF44_RS18750	COG0583	DNA-binding transcription factor activity
EHF44_RS18775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EHF44_RS18780	COG4191	Histidine kinase
EHF44_RS18795	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHF44_RS18800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS18805	COG1802	Transcriptional regulator
EHF44_RS18810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EHF44_RS18815	COG0861	Integral membrane protein TerC family
EHF44_RS18820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EHF44_RS18825	COG1522	sequence-specific DNA binding
EHF44_RS18865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHF44_RS18870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHF44_RS18880	COG1414	Transcriptional regulator
EHF44_RS18890	COG1295	ribonuclease BN
EHF44_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS18935	COG0583	DNA-binding transcription factor activity
EHF44_RS18940	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS18945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF44_RS18955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHF44_RS18975	COG0235	Class ii aldolase
EHF44_RS18985	COG1053	succinate dehydrogenase
EHF44_RS18985	COG3976	FMN-binding domain protein
EHF44_RS18985	COG0431	NADPH-dependent FMN reductase
EHF44_RS18990	COG0129	dihydroxy-acid dehydratase activity
EHF44_RS19000	COG0436	Aminotransferase
EHF44_RS19015	COG1695	Transcriptional regulator
EHF44_RS19060	COG0583	DNA-binding transcription factor activity
EHF44_RS19145	COG0583	DNA-binding transcription factor activity
EHF44_RS19170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF44_RS19180	COG0535	radical SAM domain protein
EHF44_RS19195	COG2853	Lipoprotein
EHF44_RS19200	COG5002	protein histidine kinase activity
EHF44_RS19205	COG0745	RESPONSE REGULATOR receiver
EHF44_RS19245	COG1278	Cold shock
EHF44_RS19255	COG1562	ergosterol biosynthetic process
EHF44_RS19260	COG1657	PFAM Prenyltransferase squalene oxidase
EHF44_RS19290	COG0587	DNA-directed DNA polymerase activity
EHF44_RS19345	COG1902	pentaerythritol trinitrate reductase activity
EHF44_RS19350	COG0656	L-ascorbic acid biosynthetic process
EHF44_RS19360	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS19365	COG0583	DNA-binding transcription factor activity
EHF44_RS19370	COG1024	Enoyl-CoA hydratase
EHF44_RS19375	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS19380	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS19395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS19480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHF44_RS19495	COG2223	nitrite transmembrane transporter activity
EHF44_RS19510	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS19525	COG2205	protein histidine kinase activity
EHF44_RS19530	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EHF44_RS19555	COG0583	DNA-binding transcription factor activity
EHF44_RS19560	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHF44_RS19570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF44_RS19575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHF44_RS19580	COG3485	protocatechuate 3,4-dioxygenase
EHF44_RS19585	COG3485	protocatechuate 3,4-dioxygenase
EHF44_RS19590	COG0583	DNA-binding transcription factor activity
EHF44_RS19595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHF44_RS19630	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS19640	COG2030	dehydratase
EHF44_RS19645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS19655	COG4459	periplasmic nitrate reductase
EHF44_RS19665	COG0243	molybdopterin cofactor binding
EHF44_RS19670	COG3043	anaerobic respiration
EHF44_RS19675	COG3005	denitrification pathway
EHF44_RS19680	COG4133	protoheme IX ABC transporter activity
EHF44_RS19690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHF44_RS19700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EHF44_RS19710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHF44_RS19725	COG0628	permease
EHF44_RS19735	COG0625	glutathione transferase activity
EHF44_RS19760	COG0583	DNA-binding transcription factor activity
EHF44_RS19765	COG1742	UPF0060 membrane protein
EHF44_RS19780	COG3264	Mechanosensitive ion channel
EHF44_RS19780	COG1511	domain protein
EHF44_RS19805	COG2814	Major facilitator Superfamily
EHF44_RS19855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EHF44_RS19880	COG2197	response regulator
EHF44_RS19885	COG2205	protein histidine kinase activity
EHF44_RS19885	COG0784	Response regulator, receiver
EHF44_RS19890	COG2814	Major facilitator Superfamily
EHF44_RS19905	COG0745	RESPONSE REGULATOR receiver
EHF44_RS19915	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS19925	COG0559	Belongs to the binding-protein-dependent transport system permease family
EHF44_RS19935	COG0411	ABC transporter
EHF44_RS19955	COG5001	Diguanylate cyclase
EHF44_RS19955	COG3300	MHYT domain
EHF44_RS19960	COG0840	transmembrane signaling receptor activity
EHF44_RS19985	COG2201	protein-glutamate methylesterase activity
EHF44_RS19990	COG5001	Diguanylate cyclase
EHF44_RS19990	COG4251	negative regulation of phosphorylation
EHF44_RS19990	COG2203	Gaf domain
EHF44_RS19990	COG3706	GGDEF domain
EHF44_RS20045	COG0534	Mate efflux family protein
EHF44_RS20065	COG1845	cytochrome c oxidase, subunit III
EHF44_RS20075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHF44_RS20080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHF44_RS20095	COG1773	rubredoxin
EHF44_RS20105	COG0477	Major facilitator Superfamily
EHF44_RS20115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHF44_RS20125	COG3064	Membrane
EHF44_RS20135	COG2963	transposase activity
EHF44_RS20145	COG2197	response regulator
EHF44_RS20160	COG0477	Major facilitator Superfamily
EHF44_RS20170	COG0402	S-adenosylhomocysteine deaminase activity
EHF44_RS20225	COG0322	excinuclease ABC activity
EHF44_RS20250	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS20280	COG1280	lysine exporter protein (LysE YggA)
EHF44_RS20295	COG0668	transmembrane transport
EHF44_RS20305	COG2719	SpoVR family
EHF44_RS20310	COG2718	Belongs to the UPF0229 family
EHF44_RS20315	COG2766	serine protein kinase
EHF44_RS20325	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS20330	COG0583	DNA-binding transcription factor activity
EHF44_RS20340	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS20350	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EHF44_RS20360	COG0028	Belongs to the TPP enzyme family
EHF44_RS20365	COG2188	Transcriptional regulator
EHF44_RS20390	COG0747	negative chemotaxis
EHF44_RS20400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF44_RS20405	COG4172	Belongs to the ABC transporter superfamily
EHF44_RS20420	COG1846	Transcriptional regulator
EHF44_RS20430	COG2205	protein histidine kinase activity
EHF44_RS20455	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EHF44_RS20460	COG3052	prosthetic group binding
EHF44_RS20485	COG0583	DNA-binding transcription factor activity
EHF44_RS20515	COG1024	Enoyl-CoA hydratase
EHF44_RS20525	COG0154	amidase activity
EHF44_RS20535	COG3048	D-serine ammonia-lyase activity
EHF44_RS20550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EHF44_RS20555	COG0583	DNA-binding transcription factor activity
EHF44_RS20560	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS20585	COG0583	DNA-binding transcription factor activity
EHF44_RS20590	COG2814	Major facilitator Superfamily
EHF44_RS20605	COG1538	Outer membrane efflux protein
EHF44_RS20610	COG2301	Belongs to the HpcH HpaI aldolase family
EHF44_RS20615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS20625	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS20645	COG1739	Uncharacterized protein family UPF0029
EHF44_RS20675	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EHF44_RS20685	COG0443	Heat shock 70 kDa protein
EHF44_RS20695	COG4566	intracellular signal transduction
EHF44_RS20710	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EHF44_RS20730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS20740	COG0028	Belongs to the TPP enzyme family
EHF44_RS20745	COG4566	intracellular signal transduction
EHF44_RS20755	COG0596	Alpha beta hydrolase
EHF44_RS20785	COG2133	pyrroloquinoline quinone binding
EHF44_RS20795	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS20800	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS20810	COG2207	Transcriptional regulator
EHF44_RS20810	COG4753	response regulator
EHF44_RS20815	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS20835	COG0066	3-isopropylmalate dehydratase activity
EHF44_RS20850	COG0583	DNA-binding transcription factor activity
EHF44_RS20870	COG0384	phenazine biosynthesis protein PhzF
EHF44_RS20940	COG5001	Diguanylate cyclase
EHF44_RS20940	COG3706	GGDEF domain
EHF44_RS20940	COG2203	Gaf domain
EHF44_RS20940	COG4251	negative regulation of phosphorylation
EHF44_RS20955	COG0583	DNA-binding transcription factor activity
EHF44_RS20970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHF44_RS20990	COG1309	transcriptional regulator
EHF44_RS21015	COG2945	thiolester hydrolase activity
EHF44_RS21035	COG0753	catalase activity
EHF44_RS21045	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS21050	COG2271	Major facilitator Superfamily
EHF44_RS21065	COG5001	Diguanylate cyclase
EHF44_RS21065	COG5002	protein histidine kinase activity
EHF44_RS21065	COG3447	MASE1 domain protein
EHF44_RS21075	COG0477	Major facilitator Superfamily
EHF44_RS21080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHF44_RS21085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHF44_RS21090	COG1845	cytochrome c oxidase, subunit III
EHF44_RS21095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EHF44_RS21100	COG0840	transmembrane signaling receptor activity
EHF44_RS21130	COG0833	amino acid
EHF44_RS21135	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EHF44_RS21155	COG0545	Peptidyl-prolyl cis-trans isomerase
EHF44_RS21170	COG1272	protein, Hemolysin III
EHF44_RS21190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EHF44_RS21195	COG1802	Transcriptional regulator
EHF44_RS21200	COG0247	lactate metabolic process
EHF44_RS21215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHF44_RS21225	COG0840	transmembrane signaling receptor activity
EHF44_RS21235	COG2197	response regulator
EHF44_RS21240	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS21250	COG2079	MmgE PrpD family protein
EHF44_RS21280	COG0590	tRNA wobble adenosine to inosine editing
EHF44_RS21300	COG0730	response to heat
EHF44_RS21350	COG1058	Belongs to the CinA family
EHF44_RS21350	COG1546	Belongs to the CinA family
EHF44_RS21380	COG1764	response to oxidative stress
EHF44_RS21415	COG2193	ferroxidase activity
EHF44_RS21420	COG1234	tRNA 3'-trailer cleavage
EHF44_RS21435	COG2080	2 iron, 2 sulfur cluster binding
EHF44_RS21440	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EHF44_RS21445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF44_RS21465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EHF44_RS21475	COG0243	molybdopterin cofactor binding
EHF44_RS21475	COG3383	formate dehydrogenase (NAD+) activity
EHF44_RS21480	COG0243	molybdopterin cofactor binding
EHF44_RS21480	COG3383	formate dehydrogenase (NAD+) activity
EHF44_RS21485	COG0437	4 iron, 4 sulfur cluster binding
EHF44_RS21490	COG2864	formate dehydrogenase
EHF44_RS21500	COG1921	L-seryl-tRNASec selenium transferase activity
EHF44_RS21505	COG3276	selenocysteine insertion sequence binding
EHF44_RS21515	COG1305	Transglutaminase-like
EHF44_RS21520	COG0709	Synthesizes selenophosphate from selenide and ATP
EHF44_RS21525	COG1216	Glycosyl transferase, family 2
EHF44_RS21550	COG0735	belongs to the Fur family
EHF44_RS21560	COG0697	spore germination
EHF44_RS21570	COG5001	Diguanylate cyclase
EHF44_RS21570	COG3447	MASE1 domain protein
EHF44_RS21570	COG5002	protein histidine kinase activity
EHF44_RS21585	COG0114	fumarate hydratase activity
EHF44_RS21590	COG2205	protein histidine kinase activity
EHF44_RS21605	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
EHF44_RS21620	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
EHF44_RS21640	COG2197	response regulator
EHF44_RS21645	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS21670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EHF44_RS21680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHF44_RS21685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHF44_RS21690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS21700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHF44_RS21705	COG0642	Histidine kinase
EHF44_RS21715	COG0837	glucose binding
EHF44_RS21725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EHF44_RS21735	COG0668	transmembrane transport
EHF44_RS21740	COG2207	Transcriptional regulator
EHF44_RS21750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EHF44_RS21785	COG2252	PERMEase
EHF44_RS21790	COG1278	Cold shock
EHF44_RS21800	COG1278	Cold shock
EHF44_RS21810	COG1475	DNA binding
EHF44_RS21830	COG2197	response regulator
EHF44_RS21850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EHF44_RS21855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHF44_RS21860	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS21865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHF44_RS21940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHF44_RS21960	COG0438	transferase activity, transferring glycosyl groups
EHF44_RS21965	COG0110	maltose O-acetyltransferase activity
EHF44_RS21970	COG0297	glycogen (starch) synthase activity
EHF44_RS21985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF44_RS21995	COG2197	response regulator
EHF44_RS22005	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EHF44_RS22015	COG0066	3-isopropylmalate dehydratase activity
EHF44_RS22020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHF44_RS22030	COG2188	Transcriptional regulator
EHF44_RS22080	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS22085	COG0583	DNA-binding transcription factor activity
EHF44_RS22115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHF44_RS22125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHF44_RS22185	COG0583	DNA-binding transcription factor activity
EHF44_RS22190	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS22195	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS22200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS22205	COG1139	Iron-sulfur cluster binding protein
EHF44_RS22220	COG2186	Transcriptional regulator
EHF44_RS22230	COG4303	Ethanolamine ammonia lyase large subunit
EHF44_RS22235	COG4302	ethanolamine ammonia-lyase activity
EHF44_RS22245	COG0583	DNA-binding transcription factor activity
EHF44_RS22260	COG0477	Major facilitator Superfamily
EHF44_RS22270	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS22285	COG0612	Peptidase, M16
EHF44_RS22300	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EHF44_RS22305	COG1414	Transcriptional regulator
EHF44_RS22330	COG2900	Belongs to the SlyX family
EHF44_RS22345	COG0667	Aldo Keto reductase
EHF44_RS22355	COG2261	transglycosylase associated protein
EHF44_RS22360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHF44_RS22375	COG0095	Lipoate-protein ligase
EHF44_RS22385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHF44_RS22440	COG2827	Endonuclease containing a URI domain
EHF44_RS22445	COG1764	response to oxidative stress
EHF44_RS22450	COG1846	Transcriptional regulator
EHF44_RS22455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF44_RS22465	COG0477	Major facilitator Superfamily
EHF44_RS22485	COG0714	Associated with various cellular activities
EHF44_RS22520	COG2423	ornithine cyclodeaminase activity
EHF44_RS22525	COG3069	C4-dicarboxylate transmembrane transporter activity
EHF44_RS22545	COG1414	Transcriptional regulator
EHF44_RS22560	COG0762	integral membrane protein
EHF44_RS22585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHF44_RS22590	COG3360	Dodecin
EHF44_RS22625	COG4964	Belongs to the GSP D family
EHF44_RS22670	COG0420	3'-5' exonuclease activity
EHF44_RS22675	COG0419	ATPase involved in DNA repair
EHF44_RS22685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EHF44_RS22690	COG0183	Belongs to the thiolase family
EHF44_RS22710	COG1695	Transcriptional regulator
EHF44_RS22725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EHF44_RS22735	COG0840	transmembrane signaling receptor activity
EHF44_RS22755	COG0840	transmembrane signaling receptor activity
EHF44_RS22760	COG0840	transmembrane signaling receptor activity
EHF44_RS22785	COG1360	Flagellar Motor Protein
EHF44_RS22795	COG0835	chemotaxis
EHF44_RS22800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHF44_RS22805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EHF44_RS22810	COG2201	protein-glutamate methylesterase activity
EHF44_RS22815	COG0745	RESPONSE REGULATOR receiver
EHF44_RS22820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EHF44_RS22830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHF44_RS22840	COG3132	Protein of unknown function, DUF480
EHF44_RS22845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EHF44_RS22875	COG2080	2 iron, 2 sulfur cluster binding
EHF44_RS22880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EHF44_RS22885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF44_RS22910	COG1773	rubredoxin
EHF44_RS22925	COG1295	ribonuclease BN
EHF44_RS22965	COG1749	Flagellar hook protein flgE
EHF44_RS22970	COG4787	bacterial-type flagellum-dependent cell motility
EHF44_RS22980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EHF44_RS22985	COG1706	bacterial-type flagellum-dependent cell motility
EHF44_RS22990	COG3951	Flagellar rod assembly protein muramidase FlgJ
EHF44_RS22990	COG1705	Flagellar rod assembly protein muramidase FlgJ
EHF44_RS23000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHF44_RS23040	COG2985	domain, Protein
EHF44_RS23050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EHF44_RS23055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EHF44_RS23060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF44_RS23075	COG0583	DNA-binding transcription factor activity
EHF44_RS23100	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS23105	COG2814	Major facilitator Superfamily
EHF44_RS23130	COG5265	(ABC) transporter
EHF44_RS23150	COG0438	transferase activity, transferring glycosyl groups
EHF44_RS23160	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS23165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHF44_RS23170	COG0859	PFAM glycosyl transferase family 9
EHF44_RS23175	COG2192	nodulation
EHF44_RS23180	COG1216	Glycosyl transferase, family 2
EHF44_RS23205	COG2264	protein methyltransferase activity
EHF44_RS23220	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EHF44_RS23230	COG4191	Histidine kinase
EHF44_RS23245	COG3128	pkhd-type hydroxylase
EHF44_RS23250	COG4774	siderophore transport
EHF44_RS23260	COG3064	Membrane
EHF44_RS23275	COG4191	Histidine kinase
EHF44_RS23285	COG4566	intracellular signal transduction
EHF44_RS23325	COG0628	permease
EHF44_RS23355	COG2175	clavaminate synthase activity
EHF44_RS23360	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS23370	COG0583	DNA-binding transcription factor activity
EHF44_RS23385	COG3246	L-lysine catabolic process to acetate
EHF44_RS23395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS23425	COG4251	negative regulation of phosphorylation
EHF44_RS23430	COG0784	Response regulator, receiver
EHF44_RS23435	COG2205	protein histidine kinase activity
EHF44_RS23435	COG2198	Histidine kinase
EHF44_RS23435	COG0784	Response regulator, receiver
EHF44_RS23485	COG1338	Plays a role in the flagellum-specific transport system
EHF44_RS23500	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHF44_RS23520	COG4771	TonB-dependent receptor
EHF44_RS23525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHF44_RS23530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHF44_RS23535	COG1120	ATPase activity
EHF44_RS23575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EHF44_RS23580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHF44_RS23590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHF44_RS23620	COG0596	Alpha beta hydrolase
EHF44_RS23625	COG3144	bacterial-type flagellum assembly
EHF44_RS23635	COG1157	protein secretion by the type III secretion system
EHF44_RS23645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHF44_RS23655	COG1677	Flagellar hook-basal body complex protein FliE
EHF44_RS23725	COG1334	flagellar protein FlaG
EHF44_RS23735	COG1923	regulation of RNA biosynthetic process
EHF44_RS23740	COG0840	transmembrane signaling receptor activity
EHF44_RS23755	COG1294	oxidase, subunit
EHF44_RS23760	COG1271	oxidase subunit
EHF44_RS23800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF44_RS23810	COG0583	DNA-binding transcription factor activity
EHF44_RS23820	COG0583	DNA-binding transcription factor activity
EHF44_RS23830	COG1335	isochorismatase
EHF44_RS23870	COG0583	DNA-binding transcription factor activity
EHF44_RS23895	COG2271	Major facilitator Superfamily
EHF44_RS23905	COG1012	belongs to the aldehyde dehydrogenase family
EHF44_RS23915	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS23945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS23955	COG0583	DNA-binding transcription factor activity
EHF44_RS23985	COG3546	catalase activity
EHF44_RS24040	COG4651	solute:proton antiporter activity
EHF44_RS24040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHF44_RS24050	COG3706	GGDEF domain
EHF44_RS24060	COG1132	(ABC) transporter
EHF44_RS24090	COG3162	membrane
EHF44_RS24095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHF44_RS24135	COG0129	dihydroxy-acid dehydratase activity
EHF44_RS24145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHF44_RS24150	COG0066	3-isopropylmalate dehydratase activity
EHF44_RS24160	COG2188	Transcriptional regulator
EHF44_RS24175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHF44_RS24190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS24205	COG0277	FAD linked oxidase domain protein
EHF44_RS24220	COG2721	sulfolactate sulfo-lyase activity
EHF44_RS24280	COG0583	DNA-binding transcription factor activity
EHF44_RS24295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EHF44_RS24300	COG0297	glycogen (starch) synthase activity
EHF44_RS24305	COG0058	SHG alpha-glucan phosphorylase activity
EHF44_RS24310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF44_RS24310	COG2205	protein histidine kinase activity
EHF44_RS24310	COG2198	Histidine kinase
EHF44_RS24310	COG0784	Response regulator, receiver
EHF44_RS24325	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EHF44_RS24335	COG0366	Alpha amylase catalytic
EHF44_RS24340	COG2204	response regulator
EHF44_RS24345	COG2204	response regulator
EHF44_RS24405	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS24430	COG1454	alcohol dehydrogenase
EHF44_RS24435	COG1012	belongs to the aldehyde dehydrogenase family
EHF44_RS24445	COG0826	peptidase U32
EHF44_RS24450	COG0826	peptidase U32
EHF44_RS24455	COG3154	lipid carrier protein
EHF44_RS24465	COG2814	Major facilitator Superfamily
EHF44_RS24470	COG0583	DNA-binding transcription factor activity
EHF44_RS24480	COG2916	Histone family protein nucleoid-structuring protein H-NS
EHF44_RS24485	COG2252	PERMEase
EHF44_RS24490	COG0784	Response regulator, receiver
EHF44_RS24490	COG0835	chemotaxis
EHF44_RS24495	COG0450	alkyl hydroperoxide reductase
EHF44_RS24500	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHF44_RS24515	COG2175	clavaminate synthase activity
EHF44_RS24525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EHF44_RS24530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF44_RS24545	COG1414	Transcriptional regulator
EHF44_RS24555	COG2304	oxidoreductase activity
EHF44_RS24565	COG0714	Associated with various cellular activities
EHF44_RS24570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF44_RS24575	COG2304	oxidoreductase activity
EHF44_RS24585	COG0583	DNA-binding transcription factor activity
EHF44_RS24605	COG0625	glutathione transferase activity
EHF44_RS24610	COG0583	DNA-binding transcription factor activity
EHF44_RS24615	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS24640	COG4191	Histidine kinase
EHF44_RS24645	COG0783	Belongs to the Dps family
EHF44_RS24675	COG4566	intracellular signal transduction
EHF44_RS24705	COG2132	Multicopper oxidase
EHF44_RS24715	COG5002	protein histidine kinase activity
EHF44_RS24785	COG0583	DNA-binding transcription factor activity
EHF44_RS24790	COG2271	Major facilitator Superfamily
EHF44_RS24805	COG0840	transmembrane signaling receptor activity
EHF44_RS24830	COG0427	acetyl-CoA hydrolase
EHF44_RS24835	COG0492	ferredoxin-NADP+ reductase activity
EHF44_RS24845	COG2197	response regulator
EHF44_RS24855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF44_RS24860	COG0678	peroxiredoxin activity
EHF44_RS24860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHF44_RS24875	COG0392	lysyltransferase activity
EHF44_RS24905	COG4948	Mandelate Racemase Muconate Lactonizing
EHF44_RS24910	COG4829	muconolactone delta-isomerase
EHF44_RS24920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF44_RS24925	COG0387	Pfam Sodium calcium exchanger
EHF44_RS24930	COG4772	TonB-dependent receptor
EHF44_RS24975	COG0657	acetylesterase activity
EHF44_RS24980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHF44_RS25010	COG1902	pentaerythritol trinitrate reductase activity
EHF44_RS25015	COG5002	protein histidine kinase activity
EHF44_RS25015	COG0784	Response regulator, receiver
EHF44_RS25015	COG2205	protein histidine kinase activity
EHF44_RS25020	COG2197	response regulator
EHF44_RS25030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EHF44_RS25035	COG3842	ATPase activity
EHF44_RS25045	COG4149	molybdate abc transporter
EHF44_RS25055	COG1609	Transcriptional regulator
EHF44_RS25085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS25110	COG0642	Histidine kinase
EHF44_RS25120	COG4772	TonB-dependent receptor
EHF44_RS25125	COG2814	Major facilitator Superfamily
EHF44_RS25145	COG0243	molybdopterin cofactor binding
EHF44_RS25150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHF44_RS25155	COG2146	nitrite reductase [NAD(P)H] activity
EHF44_RS25160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHF44_RS25165	COG2223	nitrite transmembrane transporter activity
EHF44_RS25180	COG5006	permease, DMT superfamily
EHF44_RS25190	COG3550	peptidyl-serine autophosphorylation
EHF44_RS25200	COG2271	Major facilitator Superfamily
EHF44_RS25215	COG0410	ABC transporter
EHF44_RS25220	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHF44_RS25235	COG1802	Transcriptional regulator
EHF44_RS25240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHF44_RS25245	COG1396	sequence-specific DNA binding
EHF44_RS25275	COG1566	PFAM secretion protein HlyD family protein
EHF44_RS25315	COG2271	Major facilitator Superfamily
EHF44_RS25320	COG1802	Transcriptional regulator
EHF44_RS25335	COG2010	Cytochrome c
EHF44_RS25365	COG0431	NADPH-dependent FMN reductase
EHF44_RS25370	COG0154	amidase activity
EHF44_RS25375	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHF44_RS25400	COG4177	L-phenylalanine transmembrane transporter activity
EHF44_RS25425	COG0683	leucine binding
EHF44_RS25440	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EHF44_RS25455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHF44_RS25460	COG0800	Aldolase
EHF44_RS25470	COG4251	negative regulation of phosphorylation
EHF44_RS25470	COG5001	Diguanylate cyclase
EHF44_RS25470	COG3706	GGDEF domain
EHF44_RS25470	COG2203	Gaf domain
EHF44_RS25475	COG1253	flavin adenine dinucleotide binding
EHF44_RS25480	COG3093	addiction module antidote protein HigA
EHF44_RS25490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHF44_RS25505	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EHF44_RS25510	COG2943	transferase activity, transferring hexosyl groups
EHF44_RS25520	COG2814	Major facilitator Superfamily
EHF44_RS25535	COG0004	ammonium transporteR
EHF44_RS25545	COG1607	acyl-coa hydrolase
EHF44_RS25550	COG3045	CreA protein
EHF44_RS25555	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS25560	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS25590	COG2271	Major facilitator Superfamily
EHF44_RS25595	COG2721	sulfolactate sulfo-lyase activity
EHF44_RS25615	COG1285	pathogenesis
EHF44_RS25625	COG0318	PFAM AMP-dependent synthetase and ligase
EHF44_RS25670	COG0840	transmembrane signaling receptor activity
EHF44_RS25675	COG3300	MHYT domain
EHF44_RS25675	COG5001	Diguanylate cyclase
EHF44_RS25685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHF44_RS25700	COG0583	DNA-binding transcription factor activity
EHF44_RS25705	COG0697	spore germination
EHF44_RS25710	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EHF44_RS25720	COG2814	Major facilitator Superfamily
EHF44_RS25730	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS25745	COG1573	uracil-dna glycosylase
EHF44_RS25755	COG0583	DNA-binding transcription factor activity
EHF44_RS25765	COG3180	Ammonia monooxygenase
EHF44_RS25795	COG0778	Nitroreductase
EHF44_RS25800	COG0204	Acyl-transferase
EHF44_RS25810	COG0697	spore germination
EHF44_RS25815	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS25820	COG3040	lipid binding
EHF44_RS25830	COG0477	Major facilitator Superfamily
EHF44_RS25840	COG2423	ornithine cyclodeaminase activity
EHF44_RS25870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHF44_RS25885	COG0583	DNA-binding transcription factor activity
EHF44_RS25890	COG1902	pentaerythritol trinitrate reductase activity
EHF44_RS25895	COG2161	toxin-antitoxin pair type II binding
EHF44_RS25900	COG4115	mRNA cleavage
EHF44_RS25905	COG4948	Mandelate Racemase Muconate Lactonizing
EHF44_RS25915	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS25965	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS25975	COG2070	2-Nitropropane dioxygenase
EHF44_RS25990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF44_RS25995	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EHF44_RS26000	COG2080	2 iron, 2 sulfur cluster binding
EHF44_RS26010	COG4999	Histidine kinase
EHF44_RS26010	COG3850	Histidine kinase
EHF44_RS26010	COG2205	protein histidine kinase activity
EHF44_RS26010	COG3437	response regulator, receiver
EHF44_RS26015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHF44_RS26040	COG0596	Alpha beta hydrolase
EHF44_RS26100	COG3339	Conserved Protein
EHF44_RS26115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EHF44_RS26125	COG0583	DNA-binding transcription factor activity
EHF44_RS26135	COG1012	belongs to the aldehyde dehydrogenase family
EHF44_RS26150	COG4948	Mandelate Racemase Muconate Lactonizing
EHF44_RS26160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF44_RS26190	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHF44_RS26195	COG1309	transcriptional regulator
EHF44_RS26200	COG0583	DNA-binding transcription factor activity
EHF44_RS26215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS26230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EHF44_RS26235	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHF44_RS26255	COG0028	Belongs to the TPP enzyme family
EHF44_RS26270	COG1309	transcriptional regulator
EHF44_RS26290	COG4221	oxidoreductase activity
EHF44_RS26295	COG2207	Transcriptional regulator
EHF44_RS26300	COG3012	SEC-C Motif Domain Protein
EHF44_RS26300	COG3318	Belongs to the UPF0149 family
EHF44_RS26310	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS26315	COG0583	DNA-binding transcription factor activity
EHF44_RS26325	COG1671	Belongs to the UPF0178 family
EHF44_RS26340	COG1024	Enoyl-CoA hydratase
EHF44_RS26370	COG0745	RESPONSE REGULATOR receiver
EHF44_RS26380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHF44_RS26385	COG0583	DNA-binding transcription factor activity
EHF44_RS26395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHF44_RS26400	COG0589	response to stress
EHF44_RS26405	COG2989	Protein conserved in bacteria
EHF44_RS26410	COG3108	Peptidase M15
EHF44_RS26415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS26435	COG1487	ribonuclease activity
EHF44_RS26450	COG0300	oxidoreductase activity
EHF44_RS26455	COG0165	Argininosuccinate lyase
EHF44_RS26465	COG1609	Transcriptional regulator
EHF44_RS26500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHF44_RS26505	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS26565	COG2814	Major facilitator Superfamily
EHF44_RS26585	COG1309	transcriptional regulator
EHF44_RS26590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EHF44_RS26605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHF44_RS26610	COG1573	uracil-dna glycosylase
EHF44_RS26615	COG1522	sequence-specific DNA binding
EHF44_RS26650	COG0629	single-stranded DNA binding
EHF44_RS26720	COG4977	sequence-specific DNA binding
EHF44_RS26720	COG1917	Cupin 2, conserved barrel domain protein
EHF44_RS26760	COG1074	ATP-dependent DNA helicase activity
EHF44_RS26810	COG1475	DNA binding
EHF44_RS26845	COG3133	Outer membrane lipoprotein
EHF44_RS26920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHF44_RS26990	COG0477	Major facilitator Superfamily
EHF44_RS26995	COG2010	Cytochrome c
EHF44_RS26995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF44_RS27000	COG2080	2 iron, 2 sulfur cluster binding
EHF44_RS27005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHF44_RS27010	COG3473	Maleate cis-trans isomerase
EHF44_RS27015	COG0596	Alpha beta hydrolase
EHF44_RS27020	COG2309	aminopeptidase activity
EHF44_RS27025	COG1335	isochorismatase
EHF44_RS27030	COG1309	transcriptional regulator
EHF44_RS27035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF44_RS27035	COG2010	Cytochrome c
EHF44_RS27040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS27050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EHF44_RS27050	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EHF44_RS27065	COG1846	Transcriptional regulator
EHF44_RS27235	COG0431	NADPH-dependent FMN reductase
EHF44_RS27245	COG0798	PFAM Bile acid sodium symporter
EHF44_RS27280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHF44_RS27285	COG1278	Cold shock
EHF44_RS27290	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS27295	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EHF44_RS27300	COG0583	DNA-binding transcription factor activity
EHF44_RS27305	COG0154	amidase activity
EHF44_RS27310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF44_RS27345	COG0066	3-isopropylmalate dehydratase activity
EHF44_RS27360	COG1196	nuclear chromosome segregation
EHF44_RS27360	COG0739	heme binding
EHF44_RS27360	COG0741	lytic transglycosylase activity
EHF44_RS27365	COG0583	DNA-binding transcription factor activity
EHF44_RS27370	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS27375	COG2271	Major facilitator Superfamily
EHF44_RS27380	COG3959	Transketolase, thiamine diphosphate binding domain
EHF44_RS27385	COG3958	Transketolase
EHF44_RS27390	COG2610	gluconate transmembrane transporter activity
EHF44_RS27400	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS27405	COG4977	sequence-specific DNA binding
EHF44_RS27425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHF44_RS27450	COG2814	Major facilitator Superfamily
EHF44_RS27465	COG1012	belongs to the aldehyde dehydrogenase family
EHF44_RS27470	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
EHF44_RS27475	COG0028	Belongs to the TPP enzyme family
EHF44_RS27480	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS27485	COG1414	Transcriptional regulator
EHF44_RS27495	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS27515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS27520	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS27530	COG4977	sequence-specific DNA binding
EHF44_RS27555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHF44_RS27570	COG4770	biotin carboxylase activity
EHF44_RS27575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHF44_RS27580	COG1960	acyl-CoA dehydrogenase activity
EHF44_RS27600	COG0583	DNA-binding transcription factor activity
EHF44_RS27605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHF44_RS27620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHF44_RS27625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHF44_RS27630	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHF44_RS27630	COG1024	Enoyl-CoA hydratase
EHF44_RS27640	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EHF44_RS27645	COG3181	Tripartite tricarboxylate transporter family receptor
EHF44_RS27660	COG0583	DNA-binding transcription factor activity
EHF44_RS27675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF44_RS27685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF44_RS27690	COG0601	transmembrane transport
EHF44_RS27695	COG0747	negative chemotaxis
EHF44_RS27700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHF44_RS27705	COG1984	allophanate hydrolase subunit 2
EHF44_RS27710	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHF44_RS27715	COG0436	Aminotransferase
EHF44_RS27735	COG3162	membrane
EHF44_RS27755	COG0656	L-ascorbic acid biosynthetic process
EHF44_RS27830	COG0463	Glycosyl transferase, family 2
EHF44_RS27830	COG0457	Tetratricopeptide repeat
EHF44_RS27835	COG3246	L-lysine catabolic process to acetate
EHF44_RS27840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHF44_RS27850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF44_RS27885	COG2916	Histone family protein nucleoid-structuring protein H-NS
EHF44_RS27895	COG2084	Dehydrogenase
EHF44_RS27900	COG1309	transcriptional regulator
EHF44_RS27915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EHF44_RS27925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF44_RS27945	COG0625	glutathione transferase activity
EHF44_RS27980	COG0583	DNA-binding transcription factor activity
EHF44_RS27985	COG1028	Short-chain dehydrogenase reductase Sdr
EHF44_RS28045	COG1192	Involved in chromosome partitioning
EHF44_RS28050	COG1475	DNA binding
EHF44_RS28105	COG3451	type IV secretory pathway VirB4
EHF44_RS28120	COG4962	Type ii secretion system protein e
EHF44_RS28180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB