locus-tag	class	description
I8920_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I8920_RS00010	COG0592	DNA-directed DNA polymerase activity
I8920_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I8920_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I8920_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I8920_RS00030	COG0187	DNA topoisomerase II activity
I8920_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8920_RS00080	COG0515	serine threonine protein kinase
I8920_RS00080	COG2815	serine threonine protein kinase
I8920_RS00085	COG0515	serine threonine protein kinase
I8920_RS00090	COG0768	penicillin binding
I8920_RS00110	COG1716	ATPase activity
I8920_RS00150	COG1802	Transcriptional regulator
I8920_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS00170	COG2271	Major facilitator Superfamily
I8920_RS00175	COG2376	Dihydroxyacetone kinase
I8920_RS00180	COG0149	triose-phosphate isomerase activity
I8920_RS00195	COG2197	response regulator
I8920_RS00205	COG3546	catalase activity
I8920_RS00240	COG0673	inositol 2-dehydrogenase activity
I8920_RS00250	COG2211	Major facilitator Superfamily
I8920_RS00275	COG2267	carboxylic ester hydrolase activity
I8920_RS00290	COG0702	epimerase
I8920_RS00295	COG2807	transmembrane transport
I8920_RS00305	COG1668	transmembrane transport
I8920_RS00310	COG4152	abc transporter atp-binding protein
I8920_RS00315	COG2264	protein methyltransferase activity
I8920_RS00340	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I8920_RS00375	COG0738	Major facilitator superfamily
I8920_RS00380	COG1609	Transcriptional regulator
I8920_RS00395	COG1309	transcriptional regulator
I8920_RS00455	COG0537	adenosine 5'-monophosphoramidase activity
I8920_RS00470	COG0534	Mate efflux family protein
I8920_RS00495	COG2233	PERMEase
I8920_RS00520	COG2267	carboxylic ester hydrolase activity
I8920_RS00540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I8920_RS00545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I8920_RS00570	COG3253	May function as heme-dependent peroxidase
I8920_RS00575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I8920_RS00580	COG0181	hydroxymethylbilane synthase activity
I8920_RS00590	COG0113	porphobilinogen synthase activity
I8920_RS00595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I8920_RS00605	COG1119	ATPase activity
I8920_RS00610	COG1802	Transcriptional regulator
I8920_RS00615	COG0604	alcohol dehydrogenase
I8920_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
I8920_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS00710	COG0778	Nitroreductase
I8920_RS00725	COG1834	amidinotransferase
I8920_RS00730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8920_RS00740	COG0667	Aldo Keto reductase
I8920_RS00760	COG0739	heme binding
I8920_RS00760	COG0741	lytic transglycosylase activity
I8920_RS00760	COG1196	nuclear chromosome segregation
I8920_RS00770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I8920_RS00775	COG0037	tRNA processing
I8920_RS00785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8920_RS00795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I8920_RS00825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I8920_RS00840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I8920_RS00845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8920_RS00885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I8920_RS00895	COG1278	Cold shock
I8920_RS00905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I8920_RS00970	COG1846	Transcriptional regulator
I8920_RS00975	COG2313	pseudouridylate synthase activity
I8920_RS00985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I8920_RS00990	COG0697	spore germination
I8920_RS00995	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8920_RS00995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8920_RS01015	COG2130	NADP-dependent
I8920_RS01040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8920_RS01060	COG2326	polyphosphate kinase activity
I8920_RS01065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I8920_RS01070	COG0656	L-ascorbic acid biosynthetic process
I8920_RS01080	COG1309	transcriptional regulator
I8920_RS01100	COG0803	Belongs to the bacterial solute-binding protein 9 family
I8920_RS01110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8920_RS01115	COG1120	ATPase activity
I8920_RS01130	COG1940	carbohydrate kinase activity
I8920_RS01130	COG1846	Transcriptional regulator
I8920_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS01230	COG4221	oxidoreductase activity
I8920_RS01235	COG0028	Belongs to the TPP enzyme family
I8920_RS01245	COG2814	Major facilitator Superfamily
I8920_RS01270	COG0667	Aldo Keto reductase
I8920_RS01295	COG0651	ATP synthesis coupled electron transport
I8920_RS01300	COG1006	Multisubunit Na H antiporter MnhC subunit
I8920_RS01305	COG2111	Na H antiporter
I8920_RS01305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8920_RS01310	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS01315	COG4221	oxidoreductase activity
I8920_RS01335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8920_RS01345	COG1316	TRANSCRIPTIONal
I8920_RS01355	COG2409	Drug exporters of the RND superfamily
I8920_RS01360	COG1802	Transcriptional regulator
I8920_RS01365	COG1316	TRANSCRIPTIONal
I8920_RS01380	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS01405	COG1764	response to oxidative stress
I8920_RS01425	COG0405	Gamma-glutamyltransferase
I8920_RS01430	COG0739	heme binding
I8920_RS01440	COG0477	Major facilitator Superfamily
I8920_RS01515	COG0546	phosphoglycolate phosphatase activity
I8920_RS01525	COG1309	transcriptional regulator
I8920_RS01535	COG1609	Transcriptional regulator
I8920_RS01540	COG1957	nucleoside hydrolase
I8920_RS01545	COG0477	Major facilitator Superfamily
I8920_RS01550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8920_RS01555	COG0248	Ppx GppA phosphatase
I8920_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS01605	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I8920_RS01615	COG3387	PFAM Glycoside hydrolase 15-related
I8920_RS01620	COG1690	Belongs to the RtcB family
I8920_RS01630	COG3386	PFAM SMP-30 Gluconolaconase
I8920_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS01650	COG0783	Belongs to the Dps family
I8920_RS01665	COG0366	Alpha amylase catalytic
I8920_RS01700	COG2814	Major facilitator Superfamily
I8920_RS01735	COG1376	ErfK ybiS ycfS ynhG family protein
I8920_RS01750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8920_RS01755	COG1950	PFAM Membrane protein of
I8920_RS01760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I8920_RS01770	COG0022	dehydrogenase e1 component
I8920_RS01775	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8920_RS01785	COG2188	Transcriptional regulator
I8920_RS01795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8920_RS01800	COG1263	PTS System
I8920_RS01810	COG1121	(ABC) transporter
I8920_RS01815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8920_RS01820	COG0735	belongs to the Fur family
I8920_RS01830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I8920_RS01835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I8920_RS01840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I8920_RS01845	COG0776	regulation of translation
I8920_RS01855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8920_RS01870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8920_RS01890	COG0701	Predicted permease
I8920_RS01905	COG1064	alcohol dehydrogenase
I8920_RS01910	COG1929	Belongs to the glycerate kinase type-1 family
I8920_RS01915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8920_RS01945	COG0717	Belongs to the dCTP deaminase family
I8920_RS01965	COG4214	carbohydrate transport
I8920_RS01975	COG1609	Transcriptional regulator
I8920_RS01980	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I8920_RS02010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I8920_RS02015	COG0673	inositol 2-dehydrogenase activity
I8920_RS02020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8920_RS02030	COG1295	ribonuclease BN
I8920_RS02045	COG0488	(ABC) transporter
I8920_RS02060	COG0395	ABC-type sugar transport system, permease component
I8920_RS02065	COG1175	transmembrane transport
I8920_RS02080	COG2271	Major facilitator Superfamily
I8920_RS02095	COG1609	Transcriptional regulator
I8920_RS02100	COG4166	transmembrane transport
I8920_RS02105	COG0601	transmembrane transport
I8920_RS02110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8920_RS02115	COG4172	Belongs to the ABC transporter superfamily
I8920_RS02120	COG0596	Alpha beta hydrolase
I8920_RS02135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8920_RS02145	COG0489	protein tyrosine kinase activity
I8920_RS02195	COG0443	Heat shock 70 kDa protein
I8920_RS02200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I8920_RS02205	COG0484	heat shock protein binding
I8920_RS02210	COG0789	Transcriptional regulator
I8920_RS02215	COG2813	Specifically methylates the guanine in position
I8920_RS02225	COG0656	L-ascorbic acid biosynthetic process
I8920_RS02245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8920_RS02255	COG0542	response to heat
I8920_RS02265	COG0745	RESPONSE REGULATOR receiver
I8920_RS02270	COG2205	protein histidine kinase activity
I8920_RS02285	COG1136	(ABC) transporter
I8920_RS02285	COG0577	efflux transmembrane transporter activity
I8920_RS02290	COG1136	(ABC) transporter
I8920_RS02290	COG0577	efflux transmembrane transporter activity
I8920_RS02295	COG2182	Extracellular solute-binding protein
I8920_RS02300	COG1175	transmembrane transport
I8920_RS02305	COG0395	ABC-type sugar transport system, permease component
I8920_RS02310	COG1349	DNA-binding transcription factor activity
I8920_RS02315	COG1105	Belongs to the carbohydrate kinase PfkB family
I8920_RS02320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8920_RS02320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8920_RS02320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8920_RS02325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I8920_RS02335	COG0586	Pfam SNARE associated Golgi protein
I8920_RS02345	COG2815	serine threonine protein kinase
I8920_RS02345	COG0515	serine threonine protein kinase
I8920_RS02350	COG0135	phosphoribosylanthranilate isomerase activity
I8920_RS02390	COG1302	Protein conserved in bacteria
I8920_RS02440	COG0739	heme binding
I8920_RS02440	COG1196	nuclear chromosome segregation
I8920_RS02440	COG0741	lytic transglycosylase activity
I8920_RS02450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I8920_RS02485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8920_RS02530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I8920_RS02565	COG2197	response regulator
I8920_RS02585	COG2770	Histidine kinase
I8920_RS02585	COG2208	phosphoserine phosphatase activity
I8920_RS02595	COG0489	protein tyrosine kinase activity
I8920_RS02605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I8920_RS02650	COG0297	glycogen (starch) synthase activity
I8920_RS02655	COG1045	serine acetyltransferase
I8920_RS02665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I8920_RS02670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8920_RS02705	COG2135	peptidase activity
I8920_RS02720	COG1764	response to oxidative stress
I8920_RS02725	COG3012	SEC-C Motif Domain Protein
I8920_RS02730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I8920_RS02745	COG0287	Prephenate dehydrogenase
I8920_RS02745	COG1605	Chorismate mutase
I8920_RS02760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8920_RS02765	COG0047	phosphoribosylformylglycinamidine synthase activity
I8920_RS02770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8920_RS02805	COG2514	catechol 2,3-dioxygenase activity
I8920_RS02835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I8920_RS02840	COG0151	Belongs to the GarS family
I8920_RS02865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I8920_RS02895	COG0531	amino acid
I8920_RS02900	COG0789	Transcriptional regulator
I8920_RS02920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8920_RS02930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8920_RS02940	COG0657	acetylesterase activity
I8920_RS02945	COG2326	polyphosphate kinase activity
I8920_RS02950	COG0513	Belongs to the DEAD box helicase family
I8920_RS02960	COG1846	Transcriptional regulator
I8920_RS02975	COG0420	3'-5' exonuclease activity
I8920_RS02980	COG0419	ATPase involved in DNA repair
I8920_RS02990	COG3764	Sortase (surface protein transpeptidase)
I8920_RS02995	COG0456	acetyltransferase
I8920_RS03025	COG0739	heme binding
I8920_RS03030	COG2084	Dehydrogenase
I8920_RS03050	COG2814	Major facilitator Superfamily
I8920_RS03075	COG2267	carboxylic ester hydrolase activity
I8920_RS03080	COG0095	Lipoate-protein ligase
I8920_RS03085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8920_RS03100	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I8920_RS03105	COG2814	Major facilitator Superfamily
I8920_RS03110	COG0033	Phosphoglucomutase
I8920_RS03140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I8920_RS03150	COG0315	cyclic pyranopterin monophosphate synthase activity
I8920_RS03155	COG0521	Mo-molybdopterin cofactor biosynthetic process
I8920_RS03155	COG0315	cyclic pyranopterin monophosphate synthase activity
I8920_RS03175	COG0488	(ABC) transporter
I8920_RS03200	COG4565	transcriptional regulatory protein
I8920_RS03205	COG3290	protein histidine kinase activity
I8920_RS03210	COG1301	dicarboxylic acid transport
I8920_RS03215	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I8920_RS03220	COG3693	PFAM glycoside hydrolase, family 10
I8920_RS03235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I8920_RS03255	COG0277	FAD linked oxidase domain protein
I8920_RS03275	COG2354	Protein conserved in bacteria
I8920_RS03315	COG2814	Major facilitator Superfamily
I8920_RS03335	COG1215	transferase activity, transferring glycosyl groups
I8920_RS03355	COG2197	response regulator
I8920_RS03365	COG0673	inositol 2-dehydrogenase activity
I8920_RS03380	COG1175	transmembrane transport
I8920_RS03390	COG1609	Transcriptional regulator
I8920_RS03415	COG2207	Transcriptional regulator
I8920_RS03420	COG1609	Transcriptional regulator
I8920_RS03430	COG1175	transmembrane transport
I8920_RS03440	COG1472	Belongs to the glycosyl hydrolase 3 family
I8920_RS03460	COG2205	protein histidine kinase activity
I8920_RS03465	COG0745	RESPONSE REGULATOR receiver
I8920_RS03490	COG3458	cephalosporin-C deacetylase activity
I8920_RS03495	COG1070	Carbohydrate kinase
I8920_RS03500	COG2115	Belongs to the xylose isomerase family
I8920_RS03505	COG0673	inositol 2-dehydrogenase activity
I8920_RS03515	COG0673	inositol 2-dehydrogenase activity
I8920_RS03525	COG1940	carbohydrate kinase activity
I8920_RS03530	COG1063	alcohol dehydrogenase
I8920_RS03540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I8920_RS03545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8920_RS03550	COG2890	protein-(glutamine-N5) methyltransferase activity
I8920_RS03565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I8920_RS03570	COG3265	gluconokinase activity
I8920_RS03580	COG3654	unkown
I8920_RS03590	COG1904	glucuronate isomerase
I8920_RS03595	COG1609	Transcriptional regulator
I8920_RS03605	COG1175	transmembrane transport
I8920_RS03610	COG0395	ABC-type sugar transport system, permease component
I8920_RS03620	COG0673	inositol 2-dehydrogenase activity
I8920_RS03630	COG0246	Mannitol dehydrogenase
I8920_RS03635	COG4948	Mandelate Racemase Muconate Lactonizing
I8920_RS03645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I8920_RS03650	COG0193	aminoacyl-tRNA hydrolase activity
I8920_RS03665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I8920_RS03670	COG3956	TIGRFAM MazG family protein
I8920_RS03675	COG0124	histidyl-tRNA synthetase
I8920_RS03680	COG0148	phosphopyruvate hydratase activity
I8920_RS03715	COG1704	LemA family
I8920_RS03725	COG3214	Protein conserved in bacteria
I8920_RS03735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8920_RS03740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I8920_RS03750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8920_RS03765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8920_RS03775	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I8920_RS03780	COG0114	fumarate hydratase activity
I8920_RS03785	COG0288	reversible hydration of carbon dioxide
I8920_RS03795	COG1722	exodeoxyribonuclease VII activity
I8920_RS03800	COG1570	exodeoxyribonuclease VII activity
I8920_RS03805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I8920_RS03815	COG1362	aminopeptidase activity
I8920_RS03820	COG0191	fructose-bisphosphate aldolase activity
I8920_RS03845	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I8920_RS03850	COG1322	Protein conserved in bacteria
I8920_RS03855	COG2176	DNA-directed DNA polymerase activity
I8920_RS03870	COG0012	GTP binding
I8920_RS04000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8920_RS04010	COG0583	DNA-binding transcription factor activity
I8920_RS04035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I8920_RS04040	COG0509	glycine decarboxylation via glycine cleavage system
I8920_RS04045	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I8920_RS04045	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I8920_RS04050	COG4166	transmembrane transport
I8920_RS04055	COG0601	transmembrane transport
I8920_RS04060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8920_RS04110	COG1217	gtp-binding protein TYPA
I8920_RS04125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8920_RS04145	COG2171	N-acyltransferase activity
I8920_RS04150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8920_RS04175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8920_RS04185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8920_RS04200	COG2239	Acts as a magnesium transporter
I8920_RS04215	COG0006	proline dipeptidase activity
I8920_RS04220	COG0613	PHP domain protein
I8920_RS04225	COG0513	Belongs to the DEAD box helicase family
I8920_RS04250	COG0210	DNA helicase
I8920_RS04255	COG3173	Aminoglycoside phosphotransferase
I8920_RS04280	COG3480	Lon protease (S16) C-terminal proteolytic domain
I8920_RS04285	COG1615	UPF0182 protein
I8920_RS04295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8920_RS04305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8920_RS04345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I8920_RS04370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I8920_RS04375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I8920_RS04380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I8920_RS04385	COG0586	Pfam SNARE associated Golgi protein
I8920_RS04400	COG0482	sulfurtransferase activity
I8920_RS04415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8920_RS04420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8920_RS04425	COG0154	amidase activity
I8920_RS04430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8920_RS04440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8920_RS04450	COG1486	melibiose metabolic process
I8920_RS04455	COG0395	ABC-type sugar transport system, permease component
I8920_RS04460	COG1175	transmembrane transport
I8920_RS04465	COG1653	transport
I8920_RS04470	COG1846	Transcriptional regulator
I8920_RS04470	COG1940	carbohydrate kinase activity
I8920_RS04525	COG0318	PFAM AMP-dependent synthetase and ligase
I8920_RS04535	COG0667	Aldo Keto reductase
I8920_RS04555	COG0667	Aldo Keto reductase
I8920_RS04585	COG4721	ABC-type cobalt transport system, permease component
I8920_RS04590	COG1122	ATPase activity
I8920_RS04600	COG0477	Major facilitator Superfamily
I8920_RS04625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I8920_RS04630	COG2814	Major facilitator Superfamily
I8920_RS04655	COG2089	acid synthase
I8920_RS04660	COG1083	cytidylyl-transferase
I8920_RS04680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I8920_RS04690	COG0629	single-stranded DNA binding
I8920_RS04710	COG1946	Acyl-CoA thioesterase
I8920_RS04725	COG0668	transmembrane transport
I8920_RS04735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8920_RS04740	COG1247	-acetyltransferase
I8920_RS04745	COG1396	sequence-specific DNA binding
I8920_RS04760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8920_RS04765	COG2808	Putative FMN-binding domain
I8920_RS04795	COG4585	Histidine kinase
I8920_RS04805	COG1609	Transcriptional regulator
I8920_RS04815	COG1175	transmembrane transport
I8920_RS04820	COG0395	ABC-type sugar transport system, permease component
I8920_RS04860	COG0544	peptidyl-prolyl cis-trans isomerase activity
I8920_RS04865	COG0740	serine-type endopeptidase activity
I8920_RS04870	COG0740	serine-type endopeptidase activity
I8920_RS04875	COG2372	response to copper ion
I8920_RS04885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I8920_RS04890	COG0339	signal peptide processing
I8920_RS04900	COG2267	carboxylic ester hydrolase activity
I8920_RS04910	COG0525	valine-tRNA ligase activity
I8920_RS04915	COG0477	Major facilitator Superfamily
I8920_RS04920	COG4172	Belongs to the ABC transporter superfamily
I8920_RS04925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8920_RS04935	COG0747	negative chemotaxis
I8920_RS04940	COG1309	transcriptional regulator
I8920_RS04960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I8920_RS04965	COG0285	dihydrofolate synthase activity
I8920_RS04975	COG0105	UTP biosynthetic process
I8920_RS04995	COG1530	ribonuclease E activity
I8920_RS05010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I8920_RS05015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I8920_RS05020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I8920_RS05025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8920_RS05030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I8920_RS05040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I8920_RS05050	COG0799	negative regulation of ribosome biogenesis
I8920_RS05060	COG2017	converts alpha-aldose to the beta-anomer
I8920_RS05075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8920_RS05080	COG0587	DNA-directed DNA polymerase activity
I8920_RS05090	COG0745	RESPONSE REGULATOR receiver
I8920_RS05110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8920_RS05120	COG3025	triphosphatase activity
I8920_RS05120	COG5607	PFAM CHAD domain containing protein
I8920_RS05130	COG3177	Filamentation induced by cAMP protein fic
I8920_RS05180	COG1027	Aspartate ammonia-lyase
I8920_RS05185	COG1295	ribonuclease BN
I8920_RS05195	COG0545	Peptidyl-prolyl cis-trans isomerase
I8920_RS05220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I8920_RS05235	COG1185	polyribonucleotide nucleotidyltransferase activity
I8920_RS05250	COG0612	Peptidase, M16
I8920_RS05255	COG0406	alpha-ribazole phosphatase activity
I8920_RS05275	COG1090	epimerase
I8920_RS05280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I8920_RS05290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8920_RS05295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8920_RS05300	COG1674	ftsk spoiiie
I8920_RS05310	COG1058	Belongs to the CinA family
I8920_RS05310	COG1546	Belongs to the CinA family
I8920_RS05315	COG1396	sequence-specific DNA binding
I8920_RS05325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I8920_RS05330	COG2137	regulation of response to DNA damage stimulus
I8920_RS05335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8920_RS05340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I8920_RS05345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I8920_RS05350	COG2813	Specifically methylates the guanine in position
I8920_RS05355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I8920_RS05360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I8920_RS05370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I8920_RS05375	COG0131	Imidazoleglycerol-phosphate dehydratase
I8920_RS05380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I8920_RS05385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I8920_RS05405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I8920_RS05420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I8920_RS05425	COG1160	GTP binding
I8920_RS05470	COG0514	ATP-dependent DNA helicase (RecQ)
I8920_RS05505	COG0114	fumarate hydratase activity
I8920_RS05560	COG1733	regulation of RNA biosynthetic process
I8920_RS05575	COG0598	Magnesium transport protein CorA
I8920_RS05595	COG4214	carbohydrate transport
I8920_RS05605	COG4213	ABC transporter substrate-binding protein
I8920_RS05610	COG1940	carbohydrate kinase activity
I8920_RS05610	COG1846	Transcriptional regulator
I8920_RS05615	COG0596	Alpha beta hydrolase
I8920_RS05660	COG1175	transmembrane transport
I8920_RS05665	COG0395	ABC-type sugar transport system, permease component
I8920_RS05690	COG1278	Cold shock
I8920_RS05765	COG0500	methyltransferase
I8920_RS05775	COG0791	NLP P60 protein
I8920_RS05780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I8920_RS05800	COG2197	response regulator
I8920_RS05805	COG4585	Histidine kinase
I8920_RS05905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8920_RS05920	COG0531	amino acid
I8920_RS05955	COG0531	amino acid
I8920_RS05970	COG0438	transferase activity, transferring glycosyl groups
I8920_RS05980	COG3285	dna ligase
I8920_RS05980	COG1793	dna ligase
I8920_RS05995	COG1793	dna ligase
I8920_RS06000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8920_RS06005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8920_RS06025	COG1012	belongs to the aldehyde dehydrogenase family
I8920_RS06050	COG1960	acyl-CoA dehydrogenase activity
I8920_RS06060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I8920_RS06070	COG4946	Tricorn protease homolog
I8920_RS06070	COG1506	peptidase
I8920_RS06070	COG0823	Involved in the tonB-independent uptake of proteins
I8920_RS06090	COG1063	alcohol dehydrogenase
I8920_RS06095	COG1733	regulation of RNA biosynthetic process
I8920_RS06120	COG0667	Aldo Keto reductase
I8920_RS06150	COG0351	phosphomethylpyrimidine kinase
I8920_RS06150	COG0352	thiamine-phosphate diphosphorylase activity
I8920_RS06150	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I8920_RS06160	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I8920_RS06175	COG0484	heat shock protein binding
I8920_RS06200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8920_RS06205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8920_RS06210	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8920_RS06215	COG1716	ATPase activity
I8920_RS06230	COG1192	Involved in chromosome partitioning
I8920_RS06250	COG1940	carbohydrate kinase activity
I8920_RS06260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I8920_RS06265	COG2815	serine threonine protein kinase
I8920_RS06265	COG0515	serine threonine protein kinase
I8920_RS06270	COG1388	LysM domain
I8920_RS06270	COG3942	CHAP domain
I8920_RS06280	COG0142	geranyltranstransferase activity
I8920_RS06290	COG2001	Belongs to the MraZ family
I8920_RS06295	COG0275	rRNA processing
I8920_RS06305	COG0768	penicillin binding
I8920_RS06310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I8920_RS06320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8920_RS06325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I8920_RS06330	COG0772	Belongs to the SEDS family
I8920_RS06335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8920_RS06340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I8920_RS06350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I8920_RS06360	COG1799	cell septum assembly
I8920_RS06375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I8920_RS06385	COG0587	DNA-directed DNA polymerase activity
I8920_RS06390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I8920_RS06395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I8920_RS06400	COG0167	dihydroorotate dehydrogenase activity
I8920_RS06410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8920_RS06420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8920_RS06425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8920_RS06435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I8920_RS06440	COG3387	PFAM Glycoside hydrolase 15-related
I8920_RS06450	COG1309	transcriptional regulator
I8920_RS06465	COG1174	glycine betaine transport
I8920_RS06475	COG1271	oxidase subunit
I8920_RS06480	COG1294	oxidase, subunit
I8920_RS06485	COG4988	ABC transporter
I8920_RS06495	COG0495	leucyl-tRNA aminoacylation
I8920_RS06500	COG1555	photosystem II stabilization
I8920_RS06500	COG1596	polysaccharide export
I8920_RS06515	COG0268	Binds directly to 16S ribosomal RNA
I8920_RS06520	COG0436	Aminotransferase
I8920_RS06525	COG0481	GTPase activity
I8920_RS06555	COG1420	regulation of RNA biosynthetic process
I8920_RS06560	COG0484	heat shock protein binding
I8920_RS06570	COG0537	adenosine 5'-monophosphoramidase activity
I8920_RS06580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I8920_RS06590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I8920_RS06595	COG4585	Histidine kinase
I8920_RS06600	COG2197	response regulator
I8920_RS06605	COG0577	efflux transmembrane transporter activity
I8920_RS06605	COG1136	(ABC) transporter
I8920_RS06615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8920_RS06620	COG1381	Involved in DNA repair and RecF pathway recombination
I8920_RS06625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8920_RS06630	COG0583	DNA-binding transcription factor activity
I8920_RS06640	COG0423	glycine-tRNA ligase activity
I8920_RS06645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8920_RS06670	COG0358	DNA primase activity
I8920_RS06675	COG4166	transmembrane transport
I8920_RS06680	COG0601	transmembrane transport
I8920_RS06685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8920_RS06690	COG4172	Belongs to the ABC transporter superfamily
I8920_RS06695	COG4608	Belongs to the ABC transporter superfamily
I8920_RS06720	COG0242	peptide deformylase activity
I8920_RS06755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8920_RS06760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8920_RS06765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8920_RS06780	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I8920_RS06790	COG0596	Alpha beta hydrolase
I8920_RS06790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8920_RS06800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I8920_RS06810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8920_RS06815	COG0736	holo-[acyl-carrier-protein] synthase activity
I8920_RS06865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8920_RS06910	COG2267	carboxylic ester hydrolase activity
I8920_RS06915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I8920_RS06925	COG3479	Phenolic acid decarboxylase
I8920_RS06935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8920_RS06950	COG2985	domain, Protein
I8920_RS06970	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS07030	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS07040	COG0395	ABC-type sugar transport system, permease component
I8920_RS07045	COG1175	transmembrane transport
I8920_RS07085	COG5398	heme oxygenase
I8920_RS07090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I8920_RS07095	COG2814	Major facilitator Superfamily
I8920_RS07100	COG1366	Belongs to the anti-sigma-factor antagonist family
I8920_RS07120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I8920_RS07155	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I8920_RS07165	COG4124	Belongs to the glycosyl hydrolase 26 family
I8920_RS07170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8920_RS07175	COG0174	glutamine synthetase
I8920_RS07195	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8920_RS07200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8920_RS07205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I8920_RS07220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I8920_RS07230	COG1492	cobalamin metabolic process
I8920_RS07240	COG0187	DNA topoisomerase II activity
I8920_RS07245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8920_RS07270	COG0756	dUTP diphosphatase activity
I8920_RS07285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I8920_RS07290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I8920_RS07295	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8920_RS07295	COG1024	Enoyl-CoA hydratase
I8920_RS07300	COG0183	Belongs to the thiolase family
I8920_RS07330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I8920_RS07340	COG0667	Aldo Keto reductase
I8920_RS07350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8920_RS07375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8920_RS07380	COG4786	Flagellar basal body rod
I8920_RS07380	COG1256	bacterial-type flagellum assembly
I8920_RS07395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8920_RS07400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I8920_RS07415	COG1815	bacterial-type flagellum-dependent cell motility
I8920_RS07425	COG1677	Flagellar hook-basal body complex protein FliE
I8920_RS07430	COG1766	The M ring may be actively involved in energy transduction
I8920_RS07435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8920_RS07445	COG1157	protein secretion by the type III secretion system
I8920_RS07455	COG0791	NLP P60 protein
I8920_RS07465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I8920_RS07475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8920_RS07495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8920_RS07505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8920_RS07510	COG1360	Flagellar Motor Protein
I8920_RS07530	COG1338	Plays a role in the flagellum-specific transport system
I8920_RS07545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8920_RS07550	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8920_RS07560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I8920_RS07570	COG3104	oligopeptide transport
I8920_RS07615	COG2814	Major facilitator Superfamily
I8920_RS07635	COG0596	Alpha beta hydrolase
I8920_RS07640	COG0753	catalase activity
I8920_RS07665	COG0747	negative chemotaxis
I8920_RS07670	COG0601	transmembrane transport
I8920_RS07675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8920_RS07680	COG4172	Belongs to the ABC transporter superfamily
I8920_RS07700	COG0783	Belongs to the Dps family
I8920_RS07710	COG1216	Glycosyl transferase, family 2
I8920_RS07715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I8920_RS07715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8920_RS07720	COG1012	belongs to the aldehyde dehydrogenase family
I8920_RS07725	COG0859	PFAM glycosyl transferase family 9
I8920_RS07735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I8920_RS07735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8920_RS07740	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I8920_RS07745	COG0438	transferase activity, transferring glycosyl groups
I8920_RS07775	COG2755	lipolytic protein G-D-S-L family
I8920_RS07780	COG0494	nUDIX hydrolase
I8920_RS07785	COG2814	Major facilitator Superfamily
I8920_RS07810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8920_RS07815	COG0542	response to heat
I8920_RS07825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8920_RS07830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I8920_RS07840	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I8920_RS07845	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I8920_RS07855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8920_RS07860	COG0217	transcriptional regulatory protein
I8920_RS07865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I8920_RS07870	COG0632	four-way junction helicase activity
I8920_RS07875	COG2255	four-way junction helicase activity
I8920_RS07885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8920_RS07890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8920_RS07905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8920_RS07915	COG1940	carbohydrate kinase activity
I8920_RS07920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I8920_RS07925	COG0702	epimerase
I8920_RS07945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8920_RS07950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8920_RS07955	COG0723	plastoquinol--plastocyanin reductase activity
I8920_RS07960	COG2010	Cytochrome c
I8920_RS07965	COG1845	cytochrome c oxidase, subunit III
I8920_RS07970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I8920_RS07975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I8920_RS07980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8920_RS07985	COG2376	Dihydroxyacetone kinase
I8920_RS07995	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I8920_RS08000	COG1132	(ABC) transporter
I8920_RS08005	COG1063	alcohol dehydrogenase
I8920_RS08035	COG1051	belongs to the nudix hydrolase family
I8920_RS08040	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS08065	COG4581	dead DEAH box helicase
I8920_RS08070	COG0805	protein transport
I8920_RS08095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8920_RS08105	COG0215	cysteine-tRNA ligase activity
I8920_RS08110	COG1968	undecaprenyl-diphosphatase activity
I8920_RS08115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8920_RS08135	COG1252	NADH dehydrogenase
I8920_RS08150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8920_RS08160	COG2755	lipolytic protein G-D-S-L family
I8920_RS08170	COG1686	Belongs to the peptidase S11 family
I8920_RS08185	COG0406	alpha-ribazole phosphatase activity
I8920_RS08205	COG0366	Alpha amylase catalytic
I8920_RS08215	COG0254	rRNA binding
I8920_RS08220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I8920_RS08225	COG0297	glycogen (starch) synthase activity
I8920_RS08230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I8920_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS08260	COG0488	(ABC) transporter
I8920_RS08265	COG1268	BioY protein
I8920_RS08270	COG2151	metal-sulfur cluster biosynthetic enzyme
I8920_RS08275	COG0396	ATPase activity
I8920_RS08285	COG0719	Fe-S assembly protein
I8920_RS08295	COG1612	heme a metabolic process
I8920_RS08300	COG0109	protoheme IX farnesyltransferase activity
I8920_RS08310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I8920_RS08315	COG0166	Belongs to the GPI family
I8920_RS08330	COG0363	glucosamine-6-phosphate deaminase activity
I8920_RS08340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8920_RS08345	COG0149	triose-phosphate isomerase activity
I8920_RS08350	COG0126	phosphoglycerate kinase activity
I8920_RS08360	COG1481	regulation of sporulation
I8920_RS08365	COG1660	Displays ATPase and GTPase activities
I8920_RS08370	COG0322	excinuclease ABC activity
I8920_RS08385	COG0556	nucleotide-excision repair
I8920_RS08390	COG0237	dephospho-CoA kinase activity
I8920_RS08440	COG0469	pyruvate kinase activity
I8920_RS08450	COG0067	glutamate synthase
I8920_RS08450	COG0069	glutamate synthase activity
I8920_RS08450	COG0070	glutamate synthase
I8920_RS08455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I8920_RS08460	COG0159	tryptophan synthase activity
I8920_RS08465	COG0133	tryptophan synthase activity
I8920_RS08470	COG0134	indole-3-glycerol-phosphate synthase activity
I8920_RS08495	COG0107	imidazoleglycerol-phosphate synthase activity
I8920_RS08500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I8920_RS08505	COG0140	phosphoribosyl-ATP diphosphatase activity
I8920_RS08510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I8920_RS08530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I8920_RS08550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I8920_RS08555	COG1758	RNA polymerase activity
I8920_RS08560	COG0194	GDP metabolic process
I8920_RS08565	COG0284	orotidine-5'-phosphate decarboxylase activity
I8920_RS08570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8920_RS08575	COG0505	Belongs to the CarA family
I8920_RS08585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8920_RS08590	COG0540	Belongs to the ATCase OTCase family
I8920_RS08595	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I8920_RS08600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I8920_RS08605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I8920_RS08610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I8920_RS08625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I8920_RS08635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I8920_RS08645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I8920_RS08650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I8920_RS08660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I8920_RS08675	COG1196	nuclear chromosome segregation
I8920_RS08680	COG0196	riboflavin kinase activity
I8920_RS08695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I8920_RS08710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I8920_RS08715	COG3266	domain, Protein
I8920_RS08715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I8920_RS08730	COG0442	prolyl-tRNA aminoacylation
I8920_RS08735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I8920_RS08750	COG0750	zinc metalloprotease
I8920_RS08755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I8920_RS08760	COG0544	peptidyl-prolyl cis-trans isomerase activity
I8920_RS08795	COG0714	Associated with various cellular activities
I8920_RS08825	COG3022	response to hydroperoxide
I8920_RS08830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I8920_RS08835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I8920_RS08840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I8920_RS08845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I8920_RS08850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I8920_RS08855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I8920_RS08860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I8920_RS08865	COG0356	it plays a direct role in the translocation of protons across the membrane
I8920_RS08875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8920_RS08890	COG2890	protein-(glutamine-N5) methyltransferase activity
I8920_RS08895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I8920_RS08905	COG0083	homoserine kinase activity
I8920_RS08915	COG0460	homoserine dehydrogenase
I8920_RS08930	COG0018	arginyl-trna synthetase
I8920_RS08950	COG0308	aminopeptidase N
I8920_RS08960	COG0024	Methionine aminopeptidase
I8920_RS08980	COG1842	Phage shock protein A
I8920_RS09000	COG1120	ATPase activity
I8920_RS09010	COG0596	Alpha beta hydrolase
I8920_RS09010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I8920_RS09025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8920_RS09035	COG4608	Belongs to the ABC transporter superfamily
I8920_RS09055	COG0488	(ABC) transporter
I8920_RS09070	COG3265	gluconokinase activity
I8920_RS09080	COG2186	Transcriptional regulator
I8920_RS09085	COG1247	-acetyltransferase
I8920_RS09090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I8920_RS09110	COG3594	Acyltransferase
I8920_RS09120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I8920_RS09140	COG2814	Major facilitator Superfamily
I8920_RS09190	COG1253	flavin adenine dinucleotide binding
I8920_RS09205	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8920_RS09205	COG0567	Dehydrogenase, E1 component
I8920_RS09230	COG1595	DNA-templated transcription, initiation
I8920_RS09235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I8920_RS09250	COG0483	inositol monophosphate 1-phosphatase activity
I8920_RS09255	COG0477	Major facilitator Superfamily
I8920_RS09260	COG2197	response regulator
I8920_RS09265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I8920_RS09275	COG2873	o-acetylhomoserine
I8920_RS09295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I8920_RS09300	COG2177	Part of the ABC transporter FtsEX involved in
I8920_RS09305	COG2884	Cell division ATP-binding protein ftsE
I8920_RS09310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I8920_RS09325	COG0477	Major facilitator Superfamily
I8920_RS09330	COG0657	acetylesterase activity
I8920_RS09345	COG0366	Alpha amylase catalytic
I8920_RS09350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I8920_RS09355	COG0492	ferredoxin-NADP+ reductase activity
I8920_RS09355	COG3118	belongs to the thioredoxin family
I8920_RS09390	COG0575	Belongs to the CDS family
I8920_RS09395	COG0233	cytoplasmic translational termination
I8920_RS09400	COG0528	UMP kinase activity
I8920_RS09405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I8920_RS09410	COG0052	Belongs to the universal ribosomal protein uS2 family
I8920_RS09415	COG0477	Major facilitator Superfamily
I8920_RS09540	COG0792	nuclease activity
I8920_RS09555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I8920_RS09560	COG0681	Belongs to the peptidase S26 family
I8920_RS09565	COG0335	large ribosomal subunit rRNA binding
I8920_RS09570	COG0024	Methionine aminopeptidase
I8920_RS09575	COG0336	Belongs to the RNA methyltransferase TrmD family
I8920_RS09580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I8920_RS09585	COG1837	Belongs to the UPF0109 family
I8920_RS09590	COG0228	four-way junction DNA binding
I8920_RS09595	COG1902	pentaerythritol trinitrate reductase activity
I8920_RS09595	COG0446	pyridine nucleotide-disulphide oxidoreductase
I8920_RS09600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I8920_RS09610	COG3541	Predicted nucleotidyltransferase
I8920_RS09615	COG0321	lipoyl(octanoyl) transferase activity
I8920_RS09620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I8920_RS09640	COG1196	nuclear chromosome segregation
I8920_RS09650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8920_RS09655	COG0571	ribonuclease III activity
I8920_RS09660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I8920_RS09670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I8920_RS09685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I8920_RS09695	COG1181	Belongs to the D-alanine--D-alanine ligase family
I8920_RS09700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I8920_RS09710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8920_RS09715	COG0066	3-isopropylmalate dehydratase activity
I8920_RS09720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I8920_RS09730	COG0406	alpha-ribazole phosphatase activity
I8920_RS09735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8920_RS09740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8920_RS09745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8920_RS09820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8920_RS09830	COG3118	belongs to the thioredoxin family
I8920_RS09830	COG0492	ferredoxin-NADP+ reductase activity
I8920_RS09835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I8920_RS09855	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8920_RS09860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8920_RS09865	COG0473	3-isopropylmalate dehydrogenase activity
I8920_RS09885	COG0246	Mannitol dehydrogenase
I8920_RS09890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I8920_RS09895	COG0440	acetolactate synthase activity
I8920_RS09900	COG0028	Belongs to the TPP enzyme family
I8920_RS09905	COG0129	dihydroxy-acid dehydratase activity
I8920_RS09925	COG0598	Magnesium transport protein CorA
I8920_RS09960	COG2205	protein histidine kinase activity
I8920_RS09965	COG0745	RESPONSE REGULATOR receiver
I8920_RS09990	COG1739	Uncharacterized protein family UPF0029
I8920_RS10025	COG0653	protein targeting
I8920_RS10030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I8920_RS10035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I8920_RS10040	COG5401	PFAM Sporulation and spore germination
I8920_RS10045	COG5000	phosphorelay sensor kinase activity
I8920_RS10045	COG5002	protein histidine kinase activity
I8920_RS10050	COG0745	RESPONSE REGULATOR receiver
I8920_RS10070	COG0714	Associated with various cellular activities
I8920_RS10090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I8920_RS10155	COG0463	Glycosyl transferase, family 2
I8920_RS10190	COG1215	transferase activity, transferring glycosyl groups
I8920_RS10215	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I8920_RS10220	COG0463	Glycosyl transferase, family 2
I8920_RS10300	COG2755	lipolytic protein G-D-S-L family
I8920_RS10300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8920_RS10325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8920_RS10340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8920_RS10365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8920_RS10370	COG0424	maF-like protein
I8920_RS10375	COG4770	biotin carboxylase activity
I8920_RS10385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8920_RS10405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I8920_RS10420	COG1079	Belongs to the binding-protein-dependent transport system permease family
I8920_RS10425	COG4603	Belongs to the binding-protein-dependent transport system permease family
I8920_RS10430	COG3845	ABC transporter
I8920_RS10445	COG0438	transferase activity, transferring glycosyl groups
I8920_RS10450	COG2009	succinate dehydrogenase
I8920_RS10460	COG1053	succinate dehydrogenase
I8920_RS10465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I8920_RS10485	COG3152	Membrane
I8920_RS10495	COG0246	Mannitol dehydrogenase
I8920_RS10500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8920_RS10510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8920_RS10525	COG0708	Exodeoxyribonuclease III
I8920_RS10530	COG0180	Tryptophanyl-tRNA synthetase
I8920_RS10545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I8920_RS10545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I8920_RS10550	COG0477	Major facilitator Superfamily
I8920_RS10560	COG1132	(ABC) transporter
I8920_RS10570	COG1335	isochorismatase
I8920_RS10575	COG2027	D-alanyl-D-alanine carboxypeptidase
I8920_RS10590	COG2273	Hydrolase Family 16
I8920_RS10605	COG0470	DNA polymerase III
I8920_RS10610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I8920_RS10615	COG1754	DNA topoisomerase type I activity
I8920_RS10615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8920_RS10645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8920_RS10665	COG1408	metallophosphoesterase
I8920_RS10680	COG2197	response regulator
I8920_RS10685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8920_RS10690	COG1435	thymidine kinase activity
I8920_RS10715	COG0579	oxidoreductase
I8920_RS10730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I8920_RS10755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I8920_RS10775	COG2814	Major facilitator Superfamily
I8920_RS10805	COG1132	(ABC) transporter
I8920_RS10810	COG0531	amino acid
I8920_RS10820	COG0222	ribosome binding
I8920_RS10825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I8920_RS10830	COG2205	protein histidine kinase activity
I8920_RS10835	COG0745	RESPONSE REGULATOR receiver
I8920_RS10845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8920_RS10860	COG1136	(ABC) transporter
I8920_RS10865	COG0823	Involved in the tonB-independent uptake of proteins
I8920_RS10870	COG0395	ABC-type sugar transport system, permease component
I8920_RS10875	COG1175	transmembrane transport
I8920_RS10880	COG2182	Extracellular solute-binding protein
I8920_RS10885	COG0673	inositol 2-dehydrogenase activity
I8920_RS10890	COG1082	Xylose isomerase domain protein TIM barrel
I8920_RS10895	COG1940	carbohydrate kinase activity
I8920_RS10910	COG0081	regulation of translation
I8920_RS10915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I8920_RS10935	COG0436	Aminotransferase
I8920_RS10940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I8920_RS10950	COG2030	dehydratase
I8920_RS10970	COG0741	lytic transglycosylase activity
I8920_RS10970	COG1196	nuclear chromosome segregation
I8920_RS10970	COG0739	heme binding
I8920_RS10975	COG0483	inositol monophosphate 1-phosphatase activity
I8920_RS10985	COG1666	GTP binding
I8920_RS10990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8920_RS11005	COG0142	geranyltranstransferase activity
I8920_RS11010	COG2226	methyltransferase
I8920_RS11020	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I8920_RS11045	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I8920_RS11055	COG4948	Mandelate Racemase Muconate Lactonizing
I8920_RS11060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8920_RS11070	COG0785	Cytochrome C biogenesis protein
I8920_RS11080	COG0406	alpha-ribazole phosphatase activity
I8920_RS11085	COG0659	secondary active sulfate transmembrane transporter activity
I8920_RS11090	COG0789	Transcriptional regulator
I8920_RS11105	COG0017	Asparaginyl-tRNA synthetase
I8920_RS11130	COG0640	Transcriptional regulator
I8920_RS11135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I8920_RS11140	COG0569	domain protein
I8920_RS11145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8920_RS11155	COG0590	tRNA wobble adenosine to inosine editing
I8920_RS11160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I8920_RS11175	COG0415	Belongs to the DNA photolyase family
I8920_RS11185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8920_RS11205	COG0477	Major facilitator Superfamily
I8920_RS11210	COG1609	Transcriptional regulator
I8920_RS11230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I8920_RS11260	COG1522	sequence-specific DNA binding
I8920_RS11290	COG2818	Glycosylase
I8920_RS11305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I8920_RS11325	COG1104	cysteine desulfurase activity
I8920_RS11335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I8920_RS11340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I8920_RS11350	COG1254	Belongs to the acylphosphatase family
I8920_RS11355	COG2814	Major facilitator Superfamily
I8920_RS11360	COG0277	FAD linked oxidase domain protein
I8920_RS11375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8920_RS11380	COG2011	ABC-type metal ion transport system permease component
I8920_RS11390	COG0477	Major facilitator Superfamily
I8920_RS11400	COG1414	Transcriptional regulator
I8920_RS11440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8920_RS11500	COG1595	DNA-templated transcription, initiation
I8920_RS11510	COG2315	Protein conserved in bacteria
I8920_RS11520	COG1045	serine acetyltransferase
I8920_RS11605	COG0038	chloride channel
I8920_RS11620	COG0598	Magnesium transport protein CorA
I8920_RS11630	COG0686	Belongs to the AlaDH PNT family
I8920_RS11635	COG2207	Transcriptional regulator
I8920_RS11645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8920_RS11650	COG0406	alpha-ribazole phosphatase activity
I8920_RS11655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I8920_RS11670	COG2390	Transcriptional regulator
I8920_RS11675	COG0698	ribose 5-phosphate isomerase
I8920_RS11750	COG1940	carbohydrate kinase activity
I8920_RS11760	COG1175	transmembrane transport
I8920_RS11765	COG0395	ABC-type sugar transport system, permease component
I8920_RS11770	COG0366	Alpha amylase catalytic
I8920_RS11775	COG1131	(ABC) transporter
I8920_RS11820	COG3046	protein related to deoxyribodipyrimidine photolyase
I8920_RS11835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8920_RS11840	COG4172	Belongs to the ABC transporter superfamily
I8920_RS11845	COG0747	negative chemotaxis
I8920_RS11855	COG0277	FAD linked oxidase domain protein
I8920_RS11860	COG2160	L-arabinose isomerase activity
I8920_RS11875	COG1609	Transcriptional regulator
I8920_RS11885	COG1609	Transcriptional regulator
I8920_RS11890	COG4213	ABC transporter substrate-binding protein
I8920_RS11895	COG1129	ABC transporter
I8920_RS11900	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8920_RS11945	COG0395	ABC-type sugar transport system, permease component
I8920_RS11955	COG1609	Transcriptional regulator
I8920_RS11960	COG3534	alpha-L-arabinofuranosidase
I8920_RS11965	COG1653	transport
I8920_RS11970	COG1175	transmembrane transport
I8920_RS11975	COG0395	ABC-type sugar transport system, permease component
I8920_RS11985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8920_RS11995	COG1120	ATPase activity
I8920_RS12005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I8920_RS12020	COG1846	Transcriptional regulator
I8920_RS12025	COG0604	alcohol dehydrogenase
I8920_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS12025	COG3321	synthase
I8920_RS12045	COG2409	Drug exporters of the RND superfamily
I8920_RS12060	COG1902	pentaerythritol trinitrate reductase activity
I8920_RS12070	COG2755	lipolytic protein G-D-S-L family
I8920_RS12070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8920_RS12080	COG0412	Dienelactone hydrolase
I8920_RS12085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I8920_RS12090	COG0673	inositol 2-dehydrogenase activity
I8920_RS12095	COG0737	Belongs to the 5'-nucleotidase family
I8920_RS12105	COG2822	iron ion transport
I8920_RS12115	COG2860	membrane
I8920_RS12135	COG0714	Associated with various cellular activities
I8920_RS12145	COG1316	TRANSCRIPTIONal
I8920_RS12155	COG0477	Major facilitator Superfamily
I8920_RS12160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I8920_RS12185	COG0738	Major facilitator superfamily
I8920_RS12190	COG0628	permease
I8920_RS12215	COG0395	ABC-type sugar transport system, permease component
I8920_RS12230	COG1609	Transcriptional regulator
I8920_RS12240	COG2222	sugar isomerase
I8920_RS12245	COG0395	ABC-type sugar transport system, permease component
I8920_RS12250	COG1175	transmembrane transport
I8920_RS12260	COG1486	melibiose metabolic process
I8920_RS12270	COG3345	alpha-galactosidase
I8920_RS12275	COG0456	acetyltransferase
I8920_RS12275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I8920_RS12290	COG0561	phosphatase activity
I8920_RS12295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I8920_RS12300	COG1597	lipid kinase activity
I8920_RS12305	COG0077	Prephenate dehydratase
I8920_RS12340	COG0387	Pfam Sodium calcium exchanger
I8920_RS12375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I8920_RS12380	COG2873	o-acetylhomoserine
I8920_RS12385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8920_RS12400	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I8920_RS12420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8920_RS12425	COG0084	hydrolase, TatD family'
I8920_RS12430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8920_RS12470	COG1331	Highly conserved protein containing a thioredoxin domain
I8920_RS12475	COG1643	Atp-dependent helicase
I8920_RS12500	COG0673	inositol 2-dehydrogenase activity
I8920_RS12510	COG1609	Transcriptional regulator
I8920_RS12530	COG1252	NADH dehydrogenase
I8920_RS12545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8920_RS12545	COG2755	lipolytic protein G-D-S-L family
I8920_RS12560	COG0318	PFAM AMP-dependent synthetase and ligase
I8920_RS12575	COG4585	Histidine kinase
I8920_RS12580	COG2197	response regulator
I8920_RS12605	COG0069	glutamate synthase activity
I8920_RS12605	COG0070	glutamate synthase
I8920_RS12605	COG0067	glutamate synthase
I8920_RS12610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8920_RS12625	COG3425	synthase
I8920_RS12645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8920_RS12650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I8920_RS12655	COG1846	Transcriptional regulator
I8920_RS12660	COG1764	response to oxidative stress
I8920_RS12665	COG3321	synthase
I8920_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS12665	COG0604	alcohol dehydrogenase
I8920_RS12675	COG2814	Major facilitator Superfamily
I8920_RS12685	COG0166	Belongs to the GPI family
I8920_RS12700	COG1937	Protein conserved in bacteria
I8920_RS12755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8920_RS12760	COG0318	PFAM AMP-dependent synthetase and ligase
I8920_RS12765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8920_RS12770	COG0189	ligase activity
I8920_RS12770	COG0569	domain protein
I8920_RS12775	COG4067	protein conserved in archaea
I8920_RS12775	COG0189	ligase activity
I8920_RS12790	COG4585	Histidine kinase
I8920_RS12795	COG2197	response regulator
I8920_RS12800	COG4152	abc transporter atp-binding protein
I8920_RS12805	COG1668	transmembrane transport
I8920_RS12810	COG3655	Transcriptional regulator
I8920_RS12855	COG2211	Major facilitator Superfamily
I8920_RS12865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I8920_RS12870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I8920_RS12875	COG1984	allophanate hydrolase subunit 2
I8920_RS12905	COG2186	Transcriptional regulator
I8920_RS12925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8920_RS12950	COG0581	inorganic phosphate transmembrane transporter activity
I8920_RS12960	COG2851	Citrate transporter
I8920_RS12965	COG3290	protein histidine kinase activity
I8920_RS12970	COG4565	transcriptional regulatory protein
I8920_RS13025	COG0745	RESPONSE REGULATOR receiver
I8920_RS13030	COG0642	Histidine kinase
I8920_RS13035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I8920_RS13035	COG4124	Belongs to the glycosyl hydrolase 26 family
I8920_RS13050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I8920_RS13110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8920_RS13115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8920_RS13120	COG1780	Probably involved in ribonucleotide reductase function
I8920_RS13135	COG0656	L-ascorbic acid biosynthetic process
I8920_RS13160	COG0328	RNA-DNA hybrid ribonuclease activity
I8920_RS13210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8920_RS13220	COG4974	Belongs to the 'phage' integrase family
I8920_RS13230	COG0494	nUDIX hydrolase
I8920_RS13235	COG0504	CTP synthase activity
I8920_RS13240	COG0497	DNA recombination
I8920_RS13245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8920_RS13260	COG0647	UMP catabolic process
I8920_RS13290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I8920_RS13295	COG2094	Belongs to the DNA glycosylase MPG family
I8920_RS13300	COG0165	Argininosuccinate lyase
I8920_RS13305	COG0137	argininosuccinate synthase activity
I8920_RS13310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I8920_RS13315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8920_RS13320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I8920_RS13325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I8920_RS13330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I8920_RS13335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8920_RS13335	COG0072	phenylalanine-tRNA ligase activity
I8920_RS13340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I8920_RS13345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8920_RS13350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I8920_RS13355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I8920_RS13360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I8920_RS13375	COG3250	beta-galactosidase activity
I8920_RS13415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8920_RS13430	COG1970	mechanosensitive ion channel activity
I8920_RS13455	COG0667	Aldo Keto reductase
I8920_RS13480	COG0765	amino acid transport
I8920_RS13500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I8920_RS13520	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS13525	COG2186	Transcriptional regulator
I8920_RS13530	COG2261	transglycosylase associated protein
I8920_RS13560	COG1175	transmembrane transport
I8920_RS13570	COG4948	Mandelate Racemase Muconate Lactonizing
I8920_RS13580	COG2268	Band 7 protein
I8920_RS13580	COG2268	Band 7 protein
I8920_RS13585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I8920_RS13595	COG0534	Mate efflux family protein
I8920_RS13610	COG0137	argininosuccinate synthase activity
I8920_RS13650	COG1278	Cold shock
I8920_RS13665	COG1061	Type III restriction enzyme res subunit
I8920_RS13670	COG0745	RESPONSE REGULATOR receiver
I8920_RS13675	COG5002	protein histidine kinase activity
I8920_RS13675	COG5000	phosphorelay sensor kinase activity
I8920_RS13685	COG0459	protein refolding
I8920_RS13690	COG1278	Cold shock
I8920_RS13715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I8920_RS13725	COG0667	Aldo Keto reductase
I8920_RS13730	COG0596	Alpha beta hydrolase
I8920_RS13735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I8920_RS13740	COG0371	Dehydrogenase
I8920_RS13755	COG3842	ATPase activity
I8920_RS13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8920_RS13770	COG0215	cysteine-tRNA ligase activity
I8920_RS13775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I8920_RS13775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I8920_RS13780	COG1329	Transcriptional regulator
I8920_RS13790	COG0745	RESPONSE REGULATOR receiver
I8920_RS13795	COG5002	protein histidine kinase activity
I8920_RS13805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I8920_RS13810	COG0588	phosphoglycerate mutase activity
I8920_RS13820	COG0354	folic acid binding
I8920_RS13825	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I8920_RS13835	COG0745	RESPONSE REGULATOR receiver
I8920_RS13840	COG0456	acetyltransferase
I8920_RS13840	COG0454	-acetyltransferase
I8920_RS13850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I8920_RS13855	COG0494	nUDIX hydrolase
I8920_RS13875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8920_RS13925	COG2755	lipolytic protein G-D-S-L family
I8920_RS13935	COG2017	converts alpha-aldose to the beta-anomer
I8920_RS13940	COG1349	DNA-binding transcription factor activity
I8920_RS13950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8920_RS13965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I8920_RS13970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I8920_RS13975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I8920_RS14005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I8920_RS14015	COG3537	Alpha-1,2-mannosidase
I8920_RS14030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8920_RS14035	COG0363	glucosamine-6-phosphate deaminase activity
I8920_RS14045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I8920_RS14045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I8920_RS14060	COG3833	ABC-type maltose transport systems, permease component
I8920_RS14065	COG1175	transmembrane transport
I8920_RS14115	COG1132	(ABC) transporter
I8920_RS14125	COG0138	bifunctional purine biosynthesis protein purh
I8920_RS14150	COG0045	succinate-CoA ligase (ADP-forming) activity
I8920_RS14185	COG1674	ftsk spoiiie
I8920_RS14230	COG0259	pyridoxamine-phosphate oxidase activity
I8920_RS14240	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I8920_RS14260	COG0584	glycerophosphoryl diester phosphodiesterase
I8920_RS14265	COG3739	integral membrane protein
I8920_RS14275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I8920_RS14275	COG0519	Catalyzes the synthesis of GMP from XMP
I8920_RS14290	COG0475	glutathione-regulated potassium exporter activity
I8920_RS14305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8920_RS14310	COG0516	GMP reductase activity
I8920_RS14315	COG1181	Belongs to the D-alanine--D-alanine ligase family
I8920_RS14320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8920_RS14360	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS14375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I8920_RS14390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I8920_RS14395	COG0456	acetyltransferase
I8920_RS14400	COG1214	PFAM Peptidase M22, glycoprotease
I8920_RS14400	COG0456	acetyltransferase
I8920_RS14405	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8920_RS14410	COG0802	atpase or kinase
I8920_RS14415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8920_RS14420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8920_RS14425	COG0736	holo-[acyl-carrier-protein] synthase activity
I8920_RS14430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I8920_RS14435	COG0386	Belongs to the glutathione peroxidase family
I8920_RS14440	COG1072	(Pantothenic acid kinase))
I8920_RS14445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8920_RS14450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I8920_RS14455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I8920_RS14465	COG0101	tRNA pseudouridine synthase activity
I8920_RS14475	COG0203	ribosomal protein L17
I8920_RS14480	COG0202	RNA polymerase activity
I8920_RS14485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I8920_RS14490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I8920_RS14495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I8920_RS14500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I8920_RS14505	COG1316	TRANSCRIPTIONal
I8920_RS14510	COG0024	Methionine aminopeptidase
I8920_RS14515	COG0563	adenylate kinase activity
I8920_RS14525	COG0200	Binds to the 23S rRNA
I8920_RS14530	COG1841	ribosomal large subunit assembly
I8920_RS14535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I8920_RS14540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I8920_RS14545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I8920_RS14550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I8920_RS14555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I8920_RS14560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I8920_RS14565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I8920_RS14570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I8920_RS14575	COG0255	Belongs to the universal ribosomal protein uL29 family
I8920_RS14580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I8920_RS14585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I8920_RS14590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I8920_RS14595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I8920_RS14600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I8920_RS14605	COG0089	rRNA binding
I8920_RS14610	COG0088	Forms part of the polypeptide exit tunnel
I8920_RS14615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I8920_RS14620	COG0051	transcription antitermination factor activity, RNA binding
I8920_RS14635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I8920_RS14640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I8920_RS14645	COG0049	tRNA binding
I8920_RS14650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I8920_RS14675	COG0849	cell division
I8920_RS14680	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I8920_RS14700	COG4968	Prepilin-type N-terminal cleavage methylation domain
I8920_RS14705	COG1459	type II secretion system
I8920_RS14715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I8920_RS14720	COG0456	acetyltransferase
I8920_RS14730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I8920_RS14735	COG0085	RNA polymerase activity
I8920_RS14745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8920_RS14800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8920_RS14810	COG0513	Belongs to the DEAD box helicase family
I8920_RS14815	COG3237	CsbD-like
I8920_RS14830	COG1201	RNA secondary structure unwinding
I8920_RS14835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8920_RS14840	COG0667	Aldo Keto reductase
I8920_RS14860	COG0531	amino acid
I8920_RS14880	COG3226	Transcriptional regulator
I8920_RS14895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8920_RS14895	COG2169	Transcriptional regulator
I8920_RS14910	COG0693	protein deglycase activity
I8920_RS14915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8920_RS14925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I8920_RS14930	COG0302	gtp cyclohydrolase
I8920_RS14935	COG2252	PERMEase
I8920_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS15010	COG2197	response regulator
I8920_RS15025	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I8920_RS15030	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I8920_RS15035	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I8920_RS15055	COG2226	methyltransferase
I8920_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS15070	COG4989	oxidoreductase activity
I8920_RS15085	COG3537	Alpha-1,2-mannosidase
I8920_RS15090	COG0515	serine threonine protein kinase
I8920_RS15090	COG2815	serine threonine protein kinase
I8920_RS15095	COG0671	phosphoesterase, PA-phosphatase related
I8920_RS15125	COG0395	ABC-type sugar transport system, permease component
I8920_RS15130	COG1175	transmembrane transport
I8920_RS15140	COG0673	inositol 2-dehydrogenase activity
I8920_RS15145	COG1349	DNA-binding transcription factor activity
I8920_RS15150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I8920_RS15155	COG1940	carbohydrate kinase activity
I8920_RS15160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I8920_RS15185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I8920_RS15210	COG0577	efflux transmembrane transporter activity
I8920_RS15210	COG1136	(ABC) transporter
I8920_RS15215	COG1136	(ABC) transporter
I8920_RS15220	COG1732	Glycine betaine
I8920_RS15225	COG1174	glycine betaine transport
I8920_RS15275	COG2838	Isocitrate dehydrogenase
I8920_RS15285	COG1196	nuclear chromosome segregation
I8920_RS15285	COG0741	lytic transglycosylase activity
I8920_RS15285	COG0739	heme binding
I8920_RS15290	COG1253	flavin adenine dinucleotide binding
I8920_RS15300	COG2226	methyltransferase
I8920_RS15310	COG0667	Aldo Keto reductase
I8920_RS15330	COG0667	Aldo Keto reductase
I8920_RS15340	COG1136	(ABC) transporter
I8920_RS15340	COG4591	ABC-type transport system involved in lipoprotein release permease component
I8920_RS15375	COG2814	Major facilitator Superfamily
I8920_RS15410	COG2197	response regulator
I8920_RS15480	COG4221	oxidoreductase activity
I8920_RS15505	COG1846	Transcriptional regulator
I8920_RS15520	COG1733	regulation of RNA biosynthetic process
I8920_RS15525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8920_RS15540	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I8920_RS15540	COG1672	PFAM Archaeal ATPase
I8920_RS15545	COG2378	regulation of single-species biofilm formation
I8920_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
I8920_RS15595	COG0305	Participates in initiation and elongation during chromosome replication
I8920_RS15600	COG0359	binds to the 23S rRNA
I8920_RS15605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I8920_RS15615	COG0360	Binds together with S18 to 16S ribosomal RNA
I8920_RS15620	COG0617	tRNA 3'-terminal CCA addition
I8920_RS15630	COG0492	ferredoxin-NADP+ reductase activity
I8920_RS15635	COG3118	belongs to the thioredoxin family
I8920_RS15640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8920_RS15655	COG1192	Involved in chromosome partitioning
I8920_RS15660	COG0357	Ribosomal RNA small subunit methyltransferase G
I8920_RS15670	COG0706	membrane insertase activity
I8920_RS15675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I8920_RS15680	COG0594	ribonuclease P activity
I8920_RS15685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I8920_RS15690	COG2814	Major facilitator Superfamily
I8920_RS15760	COG1192	Involved in chromosome partitioning
I8920_RS16005	COG4804	nuclease activity
I8920_RS16030	COG2207	Transcriptional regulator
I8920_RS16030	COG1917	Cupin 2, conserved barrel domain protein
I8920_RS16085	COG1902	pentaerythritol trinitrate reductase activity
I8920_RS16100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8920_RS16110	COG2085	NADP oxidoreductase coenzyme F420-dependent
I8920_RS16115	COG0789	Transcriptional regulator