locus-tag	class	description
ALW21_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ALW21_RS00010	COG0592	DNA-directed DNA polymerase activity
ALW21_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ALW21_RS00030	COG1132	(ABC) transporter
ALW21_RS00045	COG1482	cell wall glycoprotein biosynthetic process
ALW21_RS00050	COG0187	DNA topoisomerase II activity
ALW21_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ALW21_RS00065	COG0039	L-malate dehydrogenase activity
ALW21_RS00070	COG1609	Transcriptional regulator
ALW21_RS00075	COG1129	ABC transporter
ALW21_RS00080	COG1172	Belongs to the binding-protein-dependent transport system permease family
ALW21_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALW21_RS00095	COG1869	D-ribose catabolic process
ALW21_RS00115	COG3775	system Galactitol-specific IIC component
ALW21_RS00120	COG3414	Phosphotransferase system galactitol-specific IIB component
ALW21_RS00125	COG1063	alcohol dehydrogenase
ALW21_RS00160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALW21_RS00230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ALW21_RS00250	COG4591	ABC-type transport system involved in lipoprotein release permease component
ALW21_RS00255	COG1136	(ABC) transporter
ALW21_RS00255	COG0577	efflux transmembrane transporter activity
ALW21_RS00260	COG2197	response regulator
ALW21_RS00270	COG0395	ABC-type sugar transport system, permease component
ALW21_RS00275	COG1175	transmembrane transport
ALW21_RS00285	COG1349	DNA-binding transcription factor activity
ALW21_RS00305	COG0546	phosphoglycolate phosphatase activity
ALW21_RS00315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ALW21_RS00325	COG4585	Histidine kinase
ALW21_RS00335	COG1309	transcriptional regulator
ALW21_RS00340	COG2409	Drug exporters of the RND superfamily
ALW21_RS00360	COG1136	(ABC) transporter
ALW21_RS00375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ALW21_RS00380	COG1120	ATPase activity
ALW21_RS00395	COG0058	SHG alpha-glucan phosphorylase activity
ALW21_RS00410	COG5426	von Willebrand factor, type A
ALW21_RS00425	COG1175	transmembrane transport
ALW21_RS00430	COG0395	ABC-type sugar transport system, permease component
ALW21_RS00455	COG0205	6-phosphofructokinase activity
ALW21_RS00475	COG1027	Aspartate ammonia-lyase
ALW21_RS00480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ALW21_RS00495	COG1132	(ABC) transporter
ALW21_RS00500	COG1132	(ABC) transporter
ALW21_RS00505	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ALW21_RS00520	COG0641	radical SAM
ALW21_RS00525	COG1120	ATPase activity
ALW21_RS00540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ALW21_RS00550	COG4716	Myosin-crossreactive antigen
ALW21_RS00555	COG0351	phosphomethylpyrimidine kinase
ALW21_RS00555	COG0352	thiamine-phosphate diphosphorylase activity
ALW21_RS00555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ALW21_RS00565	COG0352	thiamine-phosphate diphosphorylase activity
ALW21_RS00585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ALW21_RS00595	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ALW21_RS00645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALW21_RS00675	COG0438	transferase activity, transferring glycosyl groups
ALW21_RS00710	COG3104	oligopeptide transport
ALW21_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
ALW21_RS00730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALW21_RS00730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALW21_RS00735	COG1105	Belongs to the carbohydrate kinase PfkB family
ALW21_RS00745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALW21_RS00755	COG0438	transferase activity, transferring glycosyl groups
ALW21_RS00765	COG0297	glycogen (starch) synthase activity
ALW21_RS00785	COG1252	NADH dehydrogenase
ALW21_RS00795	COG1643	Atp-dependent helicase
ALW21_RS00800	COG4721	ABC-type cobalt transport system, permease component
ALW21_RS00805	COG1129	ABC transporter
ALW21_RS00825	COG0167	dihydroorotate dehydrogenase activity
ALW21_RS00830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ALW21_RS00830	COG0674	pyruvate-flavodoxin oxidoreductase activity
ALW21_RS00830	COG1013	pyruvate-flavodoxin oxidoreductase activity
ALW21_RS00830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ALW21_RS00845	COG2186	Transcriptional regulator
ALW21_RS00850	COG1620	l-lactate permease
ALW21_RS00855	COG0247	lactate metabolic process
ALW21_RS00860	COG1139	Iron-sulfur cluster binding protein
ALW21_RS00865	COG1556	Lactate utilization protein
ALW21_RS00870	COG1122	ATPase activity
ALW21_RS00885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ALW21_RS00890	COG4988	ABC transporter
ALW21_RS00895	COG1294	oxidase, subunit
ALW21_RS00900	COG1271	oxidase subunit
ALW21_RS00930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ALW21_RS00945	COG2815	serine threonine protein kinase
ALW21_RS00945	COG0515	serine threonine protein kinase
ALW21_RS00950	COG0768	penicillin binding
ALW21_RS00965	COG1716	ATPase activity
ALW21_RS01080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALW21_RS01085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ALW21_RS01095	COG1136	(ABC) transporter
ALW21_RS01095	COG0577	efflux transmembrane transporter activity
ALW21_RS01110	COG0561	phosphatase activity
ALW21_RS01115	COG0561	phosphatase activity
ALW21_RS01120	COG3842	ATPase activity
ALW21_RS01130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ALW21_RS01135	COG3681	Belongs to the UPF0597 family
ALW21_RS01140	COG0814	amino acid
ALW21_RS01145	COG0673	inositol 2-dehydrogenase activity
ALW21_RS01180	COG0494	nUDIX hydrolase
ALW21_RS01190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALW21_RS01245	COG1205	dead DEAH box helicase
ALW21_RS01245	COG1111	helicase
ALW21_RS01250	COG2890	protein-(glutamine-N5) methyltransferase activity
ALW21_RS01260	COG1754	DNA topoisomerase type I activity
ALW21_RS01260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ALW21_RS01270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ALW21_RS01275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALW21_RS01285	COG1774	PSP1 C-terminal conserved region
ALW21_RS01310	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ALW21_RS01330	COG3458	cephalosporin-C deacetylase activity
ALW21_RS01340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ALW21_RS01350	COG0037	tRNA processing
ALW21_RS01365	COG0302	gtp cyclohydrolase
ALW21_RS01405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ALW21_RS01410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ALW21_RS01430	COG0649	NAD binding
ALW21_RS01460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ALW21_RS01465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ALW21_RS01470	COG1984	allophanate hydrolase subunit 2
ALW21_RS01480	COG1090	epimerase
ALW21_RS01485	COG0705	Rhomboid family
ALW21_RS01495	COG2197	response regulator
ALW21_RS01500	COG4585	Histidine kinase
ALW21_RS01510	COG3711	transcriptional antiterminator
ALW21_RS01515	COG2190	(PTS) system
ALW21_RS01515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALW21_RS01515	COG1263	PTS System
ALW21_RS01520	COG2190	(PTS) system
ALW21_RS01520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALW21_RS01520	COG1263	PTS System
ALW21_RS01525	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ALW21_RS01535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ALW21_RS01540	COG3395	kinase activity
ALW21_RS01545	COG1349	DNA-binding transcription factor activity
ALW21_RS01550	COG1194	a g-specific adenine glycosylase
ALW21_RS01555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ALW21_RS01560	COG0113	porphobilinogen synthase activity
ALW21_RS01570	COG0181	hydroxymethylbilane synthase activity
ALW21_RS01580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ALW21_RS01585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ALW21_RS01590	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALW21_RS01590	COG3253	May function as heme-dependent peroxidase
ALW21_RS01605	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ALW21_RS01610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ALW21_RS01625	COG1082	Xylose isomerase domain protein TIM barrel
ALW21_RS01630	COG0506	proline dehydrogenase activity
ALW21_RS01645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ALW21_RS01665	COG0406	alpha-ribazole phosphatase activity
ALW21_RS01670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALW21_RS01675	COG0785	Cytochrome C biogenesis protein
ALW21_RS01680	COG1333	cytochrome c biogenesis protein
ALW21_RS01685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALW21_RS01695	COG4221	oxidoreductase activity
ALW21_RS01720	COG1120	ATPase activity
ALW21_RS01725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ALW21_RS01735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ALW21_RS01755	COG0494	nUDIX hydrolase
ALW21_RS01755	COG0406	alpha-ribazole phosphatase activity
ALW21_RS01760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALW21_RS01765	COG0745	RESPONSE REGULATOR receiver
ALW21_RS01775	COG1490	D-aminoacyl-tRNA deacylase activity
ALW21_RS01780	COG3485	protocatechuate 3,4-dioxygenase
ALW21_RS01790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALW21_RS01800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ALW21_RS01805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALW21_RS01810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ALW21_RS01815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ALW21_RS01830	COG1329	Transcriptional regulator
ALW21_RS01840	COG0745	RESPONSE REGULATOR receiver
ALW21_RS01865	COG0588	phosphoglycerate mutase activity
ALW21_RS01880	COG0252	asparaginase activity
ALW21_RS01885	COG1113	amino acid transport
ALW21_RS01890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALW21_RS01895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALW21_RS01900	COG0800	Aldolase
ALW21_RS01925	COG0673	inositol 2-dehydrogenase activity
ALW21_RS01930	COG0673	inositol 2-dehydrogenase activity
ALW21_RS01940	COG5492	domain, Protein
ALW21_RS01955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALW21_RS01960	COG0215	cysteine-tRNA ligase activity
ALW21_RS02015	COG3842	ATPase activity
ALW21_RS02020	COG1760	l-serine dehydratase
ALW21_RS02025	COG0673	inositol 2-dehydrogenase activity
ALW21_RS02030	COG2182	Extracellular solute-binding protein
ALW21_RS02035	COG1175	transmembrane transport
ALW21_RS02040	COG0395	ABC-type sugar transport system, permease component
ALW21_RS02045	COG1063	alcohol dehydrogenase
ALW21_RS02060	COG1174	glycine betaine transport
ALW21_RS02085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ALW21_RS02090	COG2130	NADP-dependent
ALW21_RS02095	COG1131	(ABC) transporter
ALW21_RS02105	COG4585	Histidine kinase
ALW21_RS02110	COG2197	response regulator
ALW21_RS02115	COG0406	alpha-ribazole phosphatase activity
ALW21_RS02120	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ALW21_RS02125	COG1492	cobalamin metabolic process
ALW21_RS02145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALW21_RS02145	COG1648	precorrin-2 dehydrogenase activity
ALW21_RS02155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ALW21_RS02160	COG1120	ATPase activity
ALW21_RS02180	COG0310	cobalt ion transport
ALW21_RS02215	COG1797	cobyrinic acid a,c-diamide synthase activity
ALW21_RS02220	COG1648	precorrin-2 dehydrogenase activity
ALW21_RS02220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALW21_RS02225	COG2099	Precorrin-6x reductase
ALW21_RS02230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ALW21_RS02260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALW21_RS02260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALW21_RS02260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ALW21_RS02280	COG1854	S-ribosylhomocysteine lyase activity
ALW21_RS02300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ALW21_RS02310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALW21_RS02320	COG3718	enzyme involved in inositol metabolism
ALW21_RS02325	COG3962	Belongs to the TPP enzyme family
ALW21_RS02340	COG1609	Transcriptional regulator
ALW21_RS02350	COG1082	Xylose isomerase domain protein TIM barrel
ALW21_RS02355	COG1082	Xylose isomerase domain protein TIM barrel
ALW21_RS02360	COG0673	inositol 2-dehydrogenase activity
ALW21_RS02365	COG2814	Major facilitator Superfamily
ALW21_RS02380	COG0673	inositol 2-dehydrogenase activity
ALW21_RS02390	COG3142	Participates in the control of copper homeostasis
ALW21_RS02400	COG1061	Type III restriction enzyme res subunit
ALW21_RS02415	COG0363	glucosamine-6-phosphate deaminase activity
ALW21_RS02420	COG1278	Cold shock
ALW21_RS02435	COG2252	PERMEase
ALW21_RS02450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ALW21_RS02475	COG2814	Major facilitator Superfamily
ALW21_RS02495	COG1970	mechanosensitive ion channel activity
ALW21_RS02510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ALW21_RS02515	COG0303	'Molybdopterin
ALW21_RS02540	COG0315	cyclic pyranopterin monophosphate synthase activity
ALW21_RS02560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ALW21_RS02595	COG1140	nitrate reductase beta subunit
ALW21_RS02615	COG0521	Mo-molybdopterin cofactor biosynthetic process
ALW21_RS02615	COG0315	cyclic pyranopterin monophosphate synthase activity
ALW21_RS02630	COG0437	4 iron, 4 sulfur cluster binding
ALW21_RS02635	COG0243	molybdopterin cofactor binding
ALW21_RS02645	COG2022	thiamine diphosphate biosynthetic process
ALW21_RS02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALW21_RS02655	COG2022	thiamine diphosphate biosynthetic process
ALW21_RS02660	COG0598	Magnesium transport protein CorA
ALW21_RS02665	COG2233	PERMEase
ALW21_RS02680	COG0084	hydrolase, TatD family'
ALW21_RS02685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALW21_RS02690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ALW21_RS02695	COG1846	Transcriptional regulator
ALW21_RS02710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ALW21_RS02715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALW21_RS02735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ALW21_RS02740	COG0193	aminoacyl-tRNA hydrolase activity
ALW21_RS02790	COG0148	phosphopyruvate hydratase activity
ALW21_RS02855	COG1297	OPT oligopeptide transporter protein
ALW21_RS02860	COG0667	Aldo Keto reductase
ALW21_RS02865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALW21_RS02870	COG0733	neurotransmitter:sodium symporter activity
ALW21_RS02875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALW21_RS02890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALW21_RS02905	COG1331	Highly conserved protein containing a thioredoxin domain
ALW21_RS02910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALW21_RS02920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ALW21_RS02930	COG1722	exodeoxyribonuclease VII activity
ALW21_RS02935	COG1570	exodeoxyribonuclease VII activity
ALW21_RS02945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ALW21_RS02950	COG1322	Protein conserved in bacteria
ALW21_RS02955	COG1362	aminopeptidase activity
ALW21_RS02960	COG0012	GTP binding
ALW21_RS02980	COG1846	Transcriptional regulator
ALW21_RS02985	COG1764	response to oxidative stress
ALW21_RS03000	COG2235	arginine
ALW21_RS03005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ALW21_RS03025	COG2716	regulation of RNA biosynthetic process
ALW21_RS03030	COG0667	Aldo Keto reductase
ALW21_RS03035	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ALW21_RS03040	COG0833	amino acid
ALW21_RS03045	COG0366	Alpha amylase catalytic
ALW21_RS03045	COG3103	Sh3 type 3 domain protein
ALW21_RS03075	COG1404	Belongs to the peptidase S8 family
ALW21_RS03080	COG2501	S4 domain
ALW21_RS03085	COG1126	abc transporter atp-binding protein
ALW21_RS03090	COG0765	amino acid transport
ALW21_RS03110	COG1176	ABC-type spermidine putrescine transport system, permease component I
ALW21_RS03115	COG0395	ABC-type sugar transport system, permease component
ALW21_RS03125	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
ALW21_RS03145	COG1136	(ABC) transporter
ALW21_RS03155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALW21_RS03165	COG0803	Belongs to the bacterial solute-binding protein 9 family
ALW21_RS03180	COG1012	belongs to the aldehyde dehydrogenase family
ALW21_RS03185	COG1063	alcohol dehydrogenase
ALW21_RS03190	COG2376	Dihydroxyacetone kinase
ALW21_RS03195	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ALW21_RS03205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ALW21_RS03210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ALW21_RS03215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ALW21_RS03230	COG2171	N-acyltransferase activity
ALW21_RS03235	COG1834	amidinotransferase
ALW21_RS03245	COG0477	Major facilitator Superfamily
ALW21_RS03270	COG0297	glycogen (starch) synthase activity
ALW21_RS03275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ALW21_RS03285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALW21_RS03290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALW21_RS03325	COG0006	proline dipeptidase activity
ALW21_RS03355	COG4139	cobalamin transport
ALW21_RS03360	COG1120	ATPase activity
ALW21_RS03375	COG1966	Carbon starvation protein
ALW21_RS03395	COG0174	glutamine synthetase
ALW21_RS03405	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ALW21_RS03410	COG2966	Psort location CytoplasmicMembrane, score
ALW21_RS03430	COG0174	glutamine synthetase
ALW21_RS03440	COG0438	transferase activity, transferring glycosyl groups
ALW21_RS03450	COG1263	PTS System
ALW21_RS03455	COG2188	Transcriptional regulator
ALW21_RS03460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALW21_RS03460	COG1263	PTS System
ALW21_RS03465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ALW21_RS03475	COG3477	response to acidic pH
ALW21_RS03485	COG0488	(ABC) transporter
ALW21_RS03520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ALW21_RS03535	COG0321	lipoyl(octanoyl) transferase activity
ALW21_RS03540	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALW21_RS03545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALW21_RS03580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ALW21_RS03585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ALW21_RS03600	COG1136	(ABC) transporter
ALW21_RS03630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ALW21_RS03635	COG0723	plastoquinol--plastocyanin reductase activity
ALW21_RS03640	COG2010	Cytochrome c
ALW21_RS03645	COG1845	cytochrome c oxidase, subunit III
ALW21_RS03655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALW21_RS03670	COG0088	Forms part of the polypeptide exit tunnel
ALW21_RS03690	COG0791	NLP P60 protein
ALW21_RS03695	COG1940	carbohydrate kinase activity
ALW21_RS03715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ALW21_RS03720	COG1234	tRNA 3'-trailer cleavage
ALW21_RS03730	COG2815	serine threonine protein kinase
ALW21_RS03730	COG0515	serine threonine protein kinase
ALW21_RS03745	COG0142	geranyltranstransferase activity
ALW21_RS03755	COG0210	DNA helicase
ALW21_RS03780	COG3265	gluconokinase activity
ALW21_RS03795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALW21_RS03795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALW21_RS03800	COG0509	glycine decarboxylation via glycine cleavage system
ALW21_RS03805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ALW21_RS03825	COG0714	Associated with various cellular activities
ALW21_RS03830	COG2001	Belongs to the MraZ family
ALW21_RS03835	COG0275	rRNA processing
ALW21_RS03845	COG0768	penicillin binding
ALW21_RS03850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALW21_RS03855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ALW21_RS03860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALW21_RS03865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALW21_RS03875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ALW21_RS03880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALW21_RS03895	COG1496	oxidoreductase activity
ALW21_RS03900	COG1799	cell septum assembly
ALW21_RS03930	COG0469	pyruvate kinase activity
ALW21_RS03935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALW21_RS03940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALW21_RS03965	COG0277	FAD linked oxidase domain protein
ALW21_RS03980	COG0539	negative regulation of cytoplasmic translation
ALW21_RS03995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ALW21_RS04000	COG1120	ATPase activity
ALW21_RS04005	COG4988	ABC transporter
ALW21_RS04010	COG1132	(ABC) transporter
ALW21_RS04015	COG0237	dephospho-CoA kinase activity
ALW21_RS04025	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ALW21_RS04045	COG1120	ATPase activity
ALW21_RS04050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ALW21_RS04065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ALW21_RS04090	COG0556	nucleotide-excision repair
ALW21_RS04130	COG0322	excinuclease ABC activity
ALW21_RS04135	COG1660	Displays ATPase and GTPase activities
ALW21_RS04140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ALW21_RS04145	COG1481	regulation of sporulation
ALW21_RS04150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALW21_RS04155	COG0126	phosphoglycerate kinase activity
ALW21_RS04160	COG0149	triose-phosphate isomerase activity
ALW21_RS04165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALW21_RS04175	COG0285	dihydrofolate synthase activity
ALW21_RS04185	COG0105	UTP biosynthetic process
ALW21_RS04200	COG1530	ribonuclease E activity
ALW21_RS04205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALW21_RS04210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALW21_RS04220	COG1309	transcriptional regulator
ALW21_RS04225	COG0477	Major facilitator Superfamily
ALW21_RS04230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ALW21_RS04235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ALW21_RS04240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ALW21_RS04250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALW21_RS04260	COG0406	alpha-ribazole phosphatase activity
ALW21_RS04295	COG0488	(ABC) transporter
ALW21_RS04300	COG0488	(ABC) transporter