locus-tag	class	description
PAZ_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PAZ_RS00010	COG0592	DNA-directed DNA polymerase activity
PAZ_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PAZ_RS00045	COG1482	cell wall glycoprotein biosynthetic process
PAZ_RS00050	COG0187	DNA topoisomerase II activity
PAZ_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PAZ_RS00065	COG0039	L-malate dehydrogenase activity
PAZ_RS00070	COG1609	Transcriptional regulator
PAZ_RS00075	COG1129	ABC transporter
PAZ_RS00080	COG1172	Belongs to the binding-protein-dependent transport system permease family
PAZ_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PAZ_RS00095	COG1869	D-ribose catabolic process
PAZ_RS00115	COG3775	system Galactitol-specific IIC component
PAZ_RS00120	COG3414	Phosphotransferase system galactitol-specific IIB component
PAZ_RS00125	COG1063	alcohol dehydrogenase
PAZ_RS00235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PAZ_RS00255	COG4591	ABC-type transport system involved in lipoprotein release permease component
PAZ_RS00260	COG1136	(ABC) transporter
PAZ_RS00260	COG0577	efflux transmembrane transporter activity
PAZ_RS00265	COG2197	response regulator
PAZ_RS00280	COG0395	ABC-type sugar transport system, permease component
PAZ_RS00285	COG1175	transmembrane transport
PAZ_RS00295	COG1349	DNA-binding transcription factor activity
PAZ_RS00325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PAZ_RS00335	COG4585	Histidine kinase
PAZ_RS00345	COG1309	transcriptional regulator
PAZ_RS00350	COG2409	Drug exporters of the RND superfamily
PAZ_RS00370	COG1136	(ABC) transporter
PAZ_RS00385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAZ_RS00405	COG0058	SHG alpha-glucan phosphorylase activity
PAZ_RS00420	COG5426	von Willebrand factor, type A
PAZ_RS00435	COG1175	transmembrane transport
PAZ_RS00440	COG0395	ABC-type sugar transport system, permease component
PAZ_RS00470	COG0205	6-phosphofructokinase activity
PAZ_RS00490	COG1027	Aspartate ammonia-lyase
PAZ_RS00495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PAZ_RS00510	COG1132	(ABC) transporter
PAZ_RS00515	COG1132	(ABC) transporter
PAZ_RS00520	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PAZ_RS00535	COG0641	radical SAM
PAZ_RS00540	COG1120	ATPase activity
PAZ_RS00555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PAZ_RS00565	COG4716	Myosin-crossreactive antigen
PAZ_RS00580	COG0352	thiamine-phosphate diphosphorylase activity
PAZ_RS00600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PAZ_RS00610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PAZ_RS00660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PAZ_RS00690	COG0438	transferase activity, transferring glycosyl groups
PAZ_RS00725	COG3104	oligopeptide transport
PAZ_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
PAZ_RS00745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS00745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS00750	COG1105	Belongs to the carbohydrate kinase PfkB family
PAZ_RS00760	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PAZ_RS00780	COG0297	glycogen (starch) synthase activity
PAZ_RS00800	COG1252	NADH dehydrogenase
PAZ_RS00810	COG1643	Atp-dependent helicase
PAZ_RS00815	COG4721	ABC-type cobalt transport system, permease component
PAZ_RS00820	COG1129	ABC transporter
PAZ_RS00840	COG0167	dihydroorotate dehydrogenase activity
PAZ_RS00845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PAZ_RS00845	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PAZ_RS00845	COG0674	pyruvate-flavodoxin oxidoreductase activity
PAZ_RS00845	COG1013	pyruvate-flavodoxin oxidoreductase activity
PAZ_RS00865	COG1620	l-lactate permease
PAZ_RS00870	COG0247	lactate metabolic process
PAZ_RS00875	COG1139	Iron-sulfur cluster binding protein
PAZ_RS00880	COG1556	Lactate utilization protein
PAZ_RS00885	COG1122	ATPase activity
PAZ_RS00900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PAZ_RS00905	COG4988	ABC transporter
PAZ_RS00910	COG1294	oxidase, subunit
PAZ_RS00915	COG1271	oxidase subunit
PAZ_RS00950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PAZ_RS00965	COG2815	serine threonine protein kinase
PAZ_RS00965	COG0515	serine threonine protein kinase
PAZ_RS00970	COG0768	penicillin binding
PAZ_RS01090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PAZ_RS01095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PAZ_RS01105	COG1136	(ABC) transporter
PAZ_RS01105	COG0577	efflux transmembrane transporter activity
PAZ_RS01120	COG0561	phosphatase activity
PAZ_RS01125	COG0561	phosphatase activity
PAZ_RS01130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PAZ_RS01145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PAZ_RS01155	COG0814	amino acid
PAZ_RS01165	COG0673	inositol 2-dehydrogenase activity
PAZ_RS01200	COG0494	nUDIX hydrolase
PAZ_RS01210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PAZ_RS01265	COG1205	dead DEAH box helicase
PAZ_RS01265	COG1111	helicase
PAZ_RS01270	COG2890	protein-(glutamine-N5) methyltransferase activity
PAZ_RS01280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PAZ_RS01280	COG1754	DNA topoisomerase type I activity
PAZ_RS01290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PAZ_RS01295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PAZ_RS01305	COG1774	PSP1 C-terminal conserved region
PAZ_RS01330	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PAZ_RS01345	COG3458	cephalosporin-C deacetylase activity
PAZ_RS01355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PAZ_RS01365	COG0037	tRNA processing
PAZ_RS01380	COG0302	gtp cyclohydrolase
PAZ_RS01420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PAZ_RS01425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PAZ_RS01445	COG0649	NAD binding
PAZ_RS01475	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PAZ_RS01480	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PAZ_RS01485	COG1984	allophanate hydrolase subunit 2
PAZ_RS01495	COG1090	epimerase
PAZ_RS01500	COG0705	Rhomboid family
PAZ_RS01510	COG2197	response regulator
PAZ_RS01515	COG4585	Histidine kinase
PAZ_RS01525	COG3711	transcriptional antiterminator
PAZ_RS01530	COG2190	(PTS) system
PAZ_RS01530	COG1263	PTS System
PAZ_RS01530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PAZ_RS01535	COG1263	PTS System
PAZ_RS01535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PAZ_RS01535	COG2190	(PTS) system
PAZ_RS01550	COG1194	a g-specific adenine glycosylase
PAZ_RS01555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PAZ_RS01560	COG0113	porphobilinogen synthase activity
PAZ_RS01570	COG0181	hydroxymethylbilane synthase activity
PAZ_RS01580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PAZ_RS01585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PAZ_RS01605	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PAZ_RS01610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PAZ_RS01625	COG1082	Xylose isomerase domain protein TIM barrel
PAZ_RS01630	COG0506	proline dehydrogenase activity
PAZ_RS01645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PAZ_RS01665	COG0406	alpha-ribazole phosphatase activity
PAZ_RS01670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PAZ_RS01675	COG0785	Cytochrome C biogenesis protein
PAZ_RS01680	COG1333	cytochrome c biogenesis protein
PAZ_RS01685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PAZ_RS01695	COG4221	oxidoreductase activity
PAZ_RS01720	COG1120	ATPase activity
PAZ_RS01725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAZ_RS01735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PAZ_RS01755	COG0494	nUDIX hydrolase
PAZ_RS01755	COG0406	alpha-ribazole phosphatase activity
PAZ_RS01760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PAZ_RS01765	COG0745	RESPONSE REGULATOR receiver
PAZ_RS01775	COG1490	D-aminoacyl-tRNA deacylase activity
PAZ_RS01780	COG3485	protocatechuate 3,4-dioxygenase
PAZ_RS01790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PAZ_RS01800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PAZ_RS01805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAZ_RS01810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PAZ_RS01815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PAZ_RS01830	COG1329	Transcriptional regulator
PAZ_RS01865	COG0588	phosphoglycerate mutase activity
PAZ_RS01880	COG0252	asparaginase activity
PAZ_RS01885	COG1113	amino acid transport
PAZ_RS01890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PAZ_RS01895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PAZ_RS01900	COG0800	Aldolase
PAZ_RS01910	COG5492	domain, Protein
PAZ_RS01930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PAZ_RS01935	COG0215	cysteine-tRNA ligase activity
PAZ_RS01990	COG3842	ATPase activity
PAZ_RS02000	COG1760	l-serine dehydratase
PAZ_RS02005	COG0673	inositol 2-dehydrogenase activity
PAZ_RS02010	COG2182	Extracellular solute-binding protein
PAZ_RS02015	COG1175	transmembrane transport
PAZ_RS02020	COG0395	ABC-type sugar transport system, permease component
PAZ_RS02025	COG1063	alcohol dehydrogenase
PAZ_RS02040	COG1174	glycine betaine transport
PAZ_RS02065	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PAZ_RS02070	COG2130	NADP-dependent
PAZ_RS02075	COG1131	(ABC) transporter
PAZ_RS02085	COG4585	Histidine kinase
PAZ_RS02090	COG2197	response regulator
PAZ_RS02095	COG0406	alpha-ribazole phosphatase activity
PAZ_RS02100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PAZ_RS02105	COG1492	cobalamin metabolic process
PAZ_RS02125	COG1648	precorrin-2 dehydrogenase activity
PAZ_RS02125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PAZ_RS02140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAZ_RS02145	COG1120	ATPase activity
PAZ_RS02165	COG0310	cobalt ion transport
PAZ_RS02200	COG1797	cobyrinic acid a,c-diamide synthase activity
PAZ_RS02210	COG2099	Precorrin-6x reductase
PAZ_RS02215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PAZ_RS02245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS02245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAZ_RS02245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS02260	COG1854	S-ribosylhomocysteine lyase activity
PAZ_RS02280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PAZ_RS02290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PAZ_RS02305	COG3962	Belongs to the TPP enzyme family
PAZ_RS02320	COG1609	Transcriptional regulator
PAZ_RS02330	COG1082	Xylose isomerase domain protein TIM barrel
PAZ_RS02335	COG1082	Xylose isomerase domain protein TIM barrel
PAZ_RS02340	COG0673	inositol 2-dehydrogenase activity
PAZ_RS02345	COG2814	Major facilitator Superfamily
PAZ_RS02360	COG1082	Xylose isomerase domain protein TIM barrel
PAZ_RS02365	COG0673	inositol 2-dehydrogenase activity
PAZ_RS02375	COG3142	Participates in the control of copper homeostasis
PAZ_RS02385	COG1061	Type III restriction enzyme res subunit
PAZ_RS02400	COG0363	glucosamine-6-phosphate deaminase activity
PAZ_RS02405	COG1278	Cold shock
PAZ_RS02420	COG2252	PERMEase
PAZ_RS02435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PAZ_RS02460	COG2814	Major facilitator Superfamily
PAZ_RS02480	COG1970	mechanosensitive ion channel activity
PAZ_RS02495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PAZ_RS02500	COG0303	'Molybdopterin
PAZ_RS02525	COG0315	cyclic pyranopterin monophosphate synthase activity
PAZ_RS02580	COG1140	nitrate reductase beta subunit
PAZ_RS02600	COG0315	cyclic pyranopterin monophosphate synthase activity
PAZ_RS02600	COG0521	Mo-molybdopterin cofactor biosynthetic process
PAZ_RS02615	COG0437	4 iron, 4 sulfur cluster binding
PAZ_RS02620	COG0243	molybdopterin cofactor binding
PAZ_RS02630	COG2022	thiamine diphosphate biosynthetic process
PAZ_RS02640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PAZ_RS02640	COG2022	thiamine diphosphate biosynthetic process
PAZ_RS02645	COG0598	Magnesium transport protein CorA
PAZ_RS02650	COG2233	PERMEase
PAZ_RS02665	COG0084	hydrolase, TatD family'
PAZ_RS02670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PAZ_RS02680	COG1846	Transcriptional regulator
PAZ_RS02695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PAZ_RS02700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PAZ_RS02720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PAZ_RS02725	COG0193	aminoacyl-tRNA hydrolase activity
PAZ_RS02775	COG0148	phosphopyruvate hydratase activity
PAZ_RS02840	COG1297	OPT oligopeptide transporter protein
PAZ_RS02845	COG0667	Aldo Keto reductase
PAZ_RS02850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PAZ_RS02855	COG0733	neurotransmitter:sodium symporter activity
PAZ_RS02860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PAZ_RS02875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PAZ_RS02890	COG1331	Highly conserved protein containing a thioredoxin domain
PAZ_RS02895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PAZ_RS02905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PAZ_RS02915	COG1722	exodeoxyribonuclease VII activity
PAZ_RS02920	COG1570	exodeoxyribonuclease VII activity
PAZ_RS02930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PAZ_RS02935	COG1322	Protein conserved in bacteria
PAZ_RS02940	COG1362	aminopeptidase activity
PAZ_RS02945	COG0012	GTP binding
PAZ_RS02965	COG1846	Transcriptional regulator
PAZ_RS02970	COG1764	response to oxidative stress
PAZ_RS02985	COG2235	arginine
PAZ_RS02990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PAZ_RS03015	COG0667	Aldo Keto reductase
PAZ_RS03020	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PAZ_RS03025	COG0833	amino acid
PAZ_RS03030	COG3103	Sh3 type 3 domain protein
PAZ_RS03030	COG0366	Alpha amylase catalytic
PAZ_RS03065	COG1404	Belongs to the peptidase S8 family
PAZ_RS03070	COG2501	S4 domain
PAZ_RS03075	COG1126	abc transporter atp-binding protein
PAZ_RS03105	COG1176	ABC-type spermidine putrescine transport system, permease component I
PAZ_RS03110	COG0395	ABC-type sugar transport system, permease component
PAZ_RS03120	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
PAZ_RS03140	COG1136	(ABC) transporter
PAZ_RS03150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PAZ_RS03160	COG0803	Belongs to the bacterial solute-binding protein 9 family
PAZ_RS03175	COG1012	belongs to the aldehyde dehydrogenase family
PAZ_RS03180	COG1063	alcohol dehydrogenase
PAZ_RS03185	COG2376	Dihydroxyacetone kinase
PAZ_RS03190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PAZ_RS03200	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PAZ_RS03205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PAZ_RS03210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PAZ_RS03225	COG2171	N-acyltransferase activity
PAZ_RS03230	COG1834	amidinotransferase
PAZ_RS03240	COG0477	Major facilitator Superfamily
PAZ_RS03265	COG0297	glycogen (starch) synthase activity
PAZ_RS03270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PAZ_RS03280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PAZ_RS03285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PAZ_RS03320	COG0006	proline dipeptidase activity
PAZ_RS03345	COG4139	cobalamin transport
PAZ_RS03350	COG1120	ATPase activity
PAZ_RS03385	COG0174	glutamine synthetase
PAZ_RS03395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PAZ_RS03420	COG0174	glutamine synthetase
PAZ_RS03430	COG0438	transferase activity, transferring glycosyl groups
PAZ_RS03440	COG1263	PTS System
PAZ_RS03445	COG2188	Transcriptional regulator
PAZ_RS03450	COG1263	PTS System
PAZ_RS03450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PAZ_RS03455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PAZ_RS03465	COG3477	response to acidic pH
PAZ_RS03510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PAZ_RS03525	COG0321	lipoyl(octanoyl) transferase activity
PAZ_RS03530	COG0508	dehydrogenase complex catalyzes the overall conversion of
PAZ_RS03535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PAZ_RS03570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PAZ_RS03575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PAZ_RS03615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PAZ_RS03620	COG0723	plastoquinol--plastocyanin reductase activity
PAZ_RS03625	COG2010	Cytochrome c
PAZ_RS03630	COG1845	cytochrome c oxidase, subunit III
PAZ_RS03640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PAZ_RS03655	COG0088	Forms part of the polypeptide exit tunnel
PAZ_RS03660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PAZ_RS03680	COG1940	carbohydrate kinase activity
PAZ_RS03700	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PAZ_RS03705	COG1234	tRNA 3'-trailer cleavage
PAZ_RS03715	COG2815	serine threonine protein kinase
PAZ_RS03715	COG0515	serine threonine protein kinase
PAZ_RS03730	COG0142	geranyltranstransferase activity
PAZ_RS03740	COG0210	DNA helicase
PAZ_RS03775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PAZ_RS03775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PAZ_RS03780	COG0509	glycine decarboxylation via glycine cleavage system
PAZ_RS03785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PAZ_RS03805	COG0714	Associated with various cellular activities
PAZ_RS03810	COG2001	Belongs to the MraZ family
PAZ_RS03815	COG0275	rRNA processing
PAZ_RS03825	COG0768	penicillin binding
PAZ_RS03830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PAZ_RS03835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PAZ_RS03840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PAZ_RS03845	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PAZ_RS03855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PAZ_RS03860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PAZ_RS03875	COG1496	oxidoreductase activity
PAZ_RS03880	COG1799	cell septum assembly
PAZ_RS03910	COG0469	pyruvate kinase activity
PAZ_RS03915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PAZ_RS03920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PAZ_RS03960	COG0539	negative regulation of cytoplasmic translation
PAZ_RS03975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAZ_RS03980	COG1120	ATPase activity
PAZ_RS03985	COG4988	ABC transporter
PAZ_RS03990	COG1132	(ABC) transporter
PAZ_RS03995	COG0237	dephospho-CoA kinase activity
PAZ_RS04005	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PAZ_RS04020	COG1429	ligase activity, forming nitrogen-metal bonds
PAZ_RS04025	COG1120	ATPase activity
PAZ_RS04030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAZ_RS04065	COG0556	nucleotide-excision repair
PAZ_RS04075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PAZ_RS04105	COG0322	excinuclease ABC activity
PAZ_RS04110	COG1660	Displays ATPase and GTPase activities
PAZ_RS04115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PAZ_RS04120	COG1481	regulation of sporulation
PAZ_RS04125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PAZ_RS04130	COG0126	phosphoglycerate kinase activity
PAZ_RS04135	COG0149	triose-phosphate isomerase activity
PAZ_RS04140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PAZ_RS04150	COG0285	dihydrofolate synthase activity
PAZ_RS04160	COG0105	UTP biosynthetic process
PAZ_RS04175	COG1530	ribonuclease E activity
PAZ_RS04180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PAZ_RS04185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PAZ_RS04195	COG1309	transcriptional regulator
PAZ_RS04205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PAZ_RS04210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PAZ_RS04215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PAZ_RS04225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PAZ_RS04235	COG0406	alpha-ribazole phosphatase activity
PAZ_RS04270	COG0488	(ABC) transporter
PAZ_RS04275	COG0488	(ABC) transporter
PAZ_RS04295	COG1309	transcriptional regulator
PAZ_RS04315	COG0577	efflux transmembrane transporter activity
PAZ_RS04315	COG1136	(ABC) transporter
PAZ_RS04325	COG2197	response regulator
PAZ_RS04385	COG1735	metal-dependent hydrolase with the TIM-barrel fold
PAZ_RS04390	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PAZ_RS04410	COG2814	Major facilitator Superfamily
PAZ_RS04415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PAZ_RS04420	COG0352	thiamine-phosphate diphosphorylase activity
PAZ_RS04425	COG0039	L-malate dehydrogenase activity
PAZ_RS04430	COG0281	malic enzyme
PAZ_RS04455	COG0495	leucyl-tRNA aminoacylation
PAZ_RS04460	COG1555	photosystem II stabilization
PAZ_RS04460	COG1596	polysaccharide export
PAZ_RS04480	COG0268	Binds directly to 16S ribosomal RNA
PAZ_RS04490	COG0481	GTPase activity
PAZ_RS04495	COG4948	Mandelate Racemase Muconate Lactonizing
PAZ_RS04500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PAZ_RS04505	COG1169	isochorismate synthase
PAZ_RS04535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PAZ_RS04540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PAZ_RS04555	COG0483	inositol monophosphate 1-phosphatase activity
PAZ_RS04560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PAZ_RS04565	COG1420	regulation of RNA biosynthetic process
PAZ_RS04570	COG0484	heat shock protein binding
PAZ_RS04580	COG1063	alcohol dehydrogenase
PAZ_RS04585	COG2213	PTS system mannitol-specific
PAZ_RS04585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAZ_RS04595	COG0514	ATP-dependent DNA helicase (RecQ)
PAZ_RS04600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PAZ_RS04610	COG0343	queuine tRNA-ribosyltransferase activity
PAZ_RS04615	COG4585	Histidine kinase
PAZ_RS04625	COG4152	abc transporter atp-binding protein
PAZ_RS04660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PAZ_RS04670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PAZ_RS04675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PAZ_RS04680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PAZ_RS04685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PAZ_RS04695	COG1381	Involved in DNA repair and RecF pathway recombination
PAZ_RS04710	COG2197	response regulator
PAZ_RS04720	COG0423	glycine-tRNA ligase activity
PAZ_RS04730	COG1053	succinate dehydrogenase
PAZ_RS04740	COG0778	Nitroreductase
PAZ_RS04760	COG0358	DNA primase activity
PAZ_RS04765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PAZ_RS04780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PAZ_RS04785	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PAZ_RS04800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PAZ_RS04805	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PAZ_RS04810	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PAZ_RS04815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PAZ_RS04820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PAZ_RS04840	COG0561	phosphatase activity
PAZ_RS04850	COG0714	Associated with various cellular activities
PAZ_RS04885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PAZ_RS04890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PAZ_RS04910	COG2814	Major facilitator Superfamily
PAZ_RS04920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PAZ_RS04940	COG1335	isochorismatase
PAZ_RS04945	COG0667	Aldo Keto reductase
PAZ_RS04950	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PAZ_RS04955	COG0540	Belongs to the ATCase OTCase family
PAZ_RS04960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PAZ_RS04965	COG0505	Belongs to the CarA family
PAZ_RS04970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PAZ_RS04975	COG0543	2 iron, 2 sulfur cluster binding
PAZ_RS04980	COG0167	dihydroorotate dehydrogenase activity
PAZ_RS04985	COG0284	orotidine-5'-phosphate decarboxylase activity
PAZ_RS04990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PAZ_RS05000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PAZ_RS05010	COG1058	Belongs to the CinA family
PAZ_RS05010	COG1546	Belongs to the CinA family
PAZ_RS05015	COG1396	sequence-specific DNA binding
PAZ_RS05035	COG2137	regulation of response to DNA damage stimulus
PAZ_RS05040	COG1418	mRNA catabolic process
PAZ_RS05045	COG2017	converts alpha-aldose to the beta-anomer
PAZ_RS05050	COG1288	antiporter activity
PAZ_RS05055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PAZ_RS05065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PAZ_RS05070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PAZ_RS05075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PAZ_RS05085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PAZ_RS05095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PAZ_RS05100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PAZ_RS05115	COG1643	Atp-dependent helicase
PAZ_RS05120	COG1946	Acyl-CoA thioesterase
PAZ_RS05125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PAZ_RS05130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PAZ_RS05140	COG1309	transcriptional regulator
PAZ_RS05180	COG0187	DNA topoisomerase II activity
PAZ_RS05185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PAZ_RS05195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PAZ_RS05215	COG1435	thymidine kinase activity
PAZ_RS05240	COG0756	dUTP diphosphatase activity
PAZ_RS05260	COG0569	domain protein
PAZ_RS05265	COG0531	amino acid
PAZ_RS05270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PAZ_RS05280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PAZ_RS05285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PAZ_RS05300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PAZ_RS05310	COG2964	Protein conserved in bacteria
PAZ_RS05320	COG1113	amino acid transport
PAZ_RS05325	COG2326	polyphosphate kinase activity
PAZ_RS05350	COG1064	alcohol dehydrogenase
PAZ_RS05355	COG3850	Histidine kinase
PAZ_RS05365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PAZ_RS05375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PAZ_RS05400	COG0509	glycine decarboxylation via glycine cleavage system
PAZ_RS05405	COG1716	ATPase activity
PAZ_RS05425	COG1295	ribonuclease BN
PAZ_RS05435	COG0205	6-phosphofructokinase activity
PAZ_RS05440	COG0009	L-threonylcarbamoyladenylate synthase
PAZ_RS05455	COG1739	Uncharacterized protein family UPF0029
PAZ_RS05465	COG0443	Heat shock 70 kDa protein
PAZ_RS05505	COG0033	Phosphoglucomutase
PAZ_RS05515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PAZ_RS05535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PAZ_RS05550	COG0366	Alpha amylase catalytic
PAZ_RS05565	COG0482	sulfurtransferase activity
PAZ_RS05590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PAZ_RS05595	COG0154	amidase activity
PAZ_RS05600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PAZ_RS05610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PAZ_RS05630	COG0134	indole-3-glycerol-phosphate synthase activity
PAZ_RS05635	COG0133	tryptophan synthase activity
PAZ_RS05645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PAZ_RS05650	COG0067	glutamate synthase
PAZ_RS05650	COG0069	glutamate synthase activity
PAZ_RS05650	COG0070	glutamate synthase
PAZ_RS05665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PAZ_RS05675	COG1737	Transcriptional regulator
PAZ_RS05680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PAZ_RS05695	COG2971	BadF BadG BcrA BcrD
PAZ_RS05705	COG2723	6-phospho-beta-galactosidase activity
PAZ_RS05710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PAZ_RS05715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PAZ_RS05720	COG1447	Phosphotransferase system cellobiose-specific component IIA
PAZ_RS05740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PAZ_RS05745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PAZ_RS05750	COG0131	Imidazoleglycerol-phosphate dehydratase
PAZ_RS05755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PAZ_RS05760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PAZ_RS05765	COG0217	transcriptional regulatory protein
PAZ_RS05770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PAZ_RS05775	COG0632	four-way junction helicase activity
PAZ_RS05780	COG2255	four-way junction helicase activity
PAZ_RS05790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PAZ_RS05795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PAZ_RS05800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PAZ_RS05810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PAZ_RS05815	COG1196	nuclear chromosome segregation
PAZ_RS05820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PAZ_RS05825	COG0124	histidyl-tRNA synthetase
PAZ_RS05855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PAZ_RS05870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PAZ_RS05875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PAZ_RS05880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PAZ_RS05885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PAZ_RS05890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PAZ_RS05895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PAZ_RS05900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PAZ_RS05915	COG2326	polyphosphate kinase activity
PAZ_RS05920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PAZ_RS05925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PAZ_RS05935	COG0194	GDP metabolic process
PAZ_RS05940	COG1758	RNA polymerase activity
PAZ_RS05950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PAZ_RS05960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PAZ_RS05980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PAZ_RS06000	COG1511	domain protein
PAZ_RS06005	COG1129	ABC transporter
PAZ_RS06015	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PAZ_RS06020	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PAZ_RS06030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PAZ_RS06035	COG1160	GTP binding
PAZ_RS06045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PAZ_RS06055	COG0738	Major facilitator superfamily
PAZ_RS06060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PAZ_RS06075	COG0427	acetyl-CoA hydrolase
PAZ_RS06090	COG1522	sequence-specific DNA binding
PAZ_RS06100	COG1216	Glycosyl transferase, family 2
PAZ_RS06115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PAZ_RS06130	COG1230	cation diffusion facilitator family transporter
PAZ_RS06150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PAZ_RS06155	COG2814	Major facilitator Superfamily
PAZ_RS06160	COG1846	Transcriptional regulator
PAZ_RS06185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PAZ_RS06190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PAZ_RS06195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PAZ_RS06200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PAZ_RS06205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PAZ_RS06210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PAZ_RS06215	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PAZ_RS06220	COG0356	it plays a direct role in the translocation of protons across the membrane
PAZ_RS06235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PAZ_RS06245	COG2890	protein-(glutamine-N5) methyltransferase activity
PAZ_RS06250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PAZ_RS06255	COG0254	rRNA binding
PAZ_RS06265	COG0083	homoserine kinase activity
PAZ_RS06270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PAZ_RS06275	COG0460	homoserine dehydrogenase
PAZ_RS06295	COG0508	dehydrogenase complex catalyzes the overall conversion of
PAZ_RS06295	COG0567	Dehydrogenase, E1 component
PAZ_RS06325	COG1595	DNA-templated transcription, initiation
PAZ_RS06335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PAZ_RS06340	COG1162	GTPase activity
PAZ_RS06350	COG0483	inositol monophosphate 1-phosphatase activity
PAZ_RS06355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PAZ_RS06365	COG0444	Belongs to the ABC transporter superfamily
PAZ_RS06370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PAZ_RS06375	COG0601	transmembrane transport
PAZ_RS06380	COG0747	negative chemotaxis
PAZ_RS06530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PAZ_RS06555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PAZ_RS06560	COG1074	ATP-dependent DNA helicase activity
PAZ_RS06565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PAZ_RS06605	COG1113	amino acid transport
PAZ_RS06610	COG0180	Tryptophanyl-tRNA synthetase
PAZ_RS06615	COG0613	PHP domain protein
PAZ_RS06620	COG2902	Dehydrogenase
PAZ_RS06635	COG0653	protein targeting
PAZ_RS06640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PAZ_RS06650	COG5401	PFAM Sporulation and spore germination
PAZ_RS06655	COG5000	phosphorelay sensor kinase activity
PAZ_RS06655	COG5002	protein histidine kinase activity
PAZ_RS06660	COG0745	RESPONSE REGULATOR receiver
PAZ_RS06665	COG1678	Uncharacterized ACR, COG1678
PAZ_RS06715	COG0165	Argininosuccinate lyase
PAZ_RS06720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PAZ_RS06725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PAZ_RS06735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PAZ_RS06740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PAZ_RS06745	COG2177	Part of the ABC transporter FtsEX involved in
PAZ_RS06750	COG2884	Cell division ATP-binding protein ftsE
PAZ_RS06755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PAZ_RS06770	COG1674	ftsk spoiiie
PAZ_RS06790	COG1181	Belongs to the D-alanine--D-alanine ligase family
PAZ_RS06815	COG1414	Transcriptional regulator
PAZ_RS06830	COG1266	CAAX protease self-immunity
PAZ_RS06845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PAZ_RS06850	COG0473	3-isopropylmalate dehydrogenase activity
PAZ_RS06855	COG0473	3-isopropylmalate dehydrogenase activity
PAZ_RS06865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PAZ_RS06880	COG0537	adenosine 5'-monophosphoramidase activity
PAZ_RS06885	COG0107	imidazoleglycerol-phosphate synthase activity
PAZ_RS06890	COG4581	dead DEAH box helicase
PAZ_RS06895	COG0805	protein transport
PAZ_RS06900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PAZ_RS06920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PAZ_RS06925	COG0545	Peptidyl-prolyl cis-trans isomerase
PAZ_RS06945	COG4974	Belongs to the 'phage' integrase family
PAZ_RS06950	COG0494	nUDIX hydrolase
PAZ_RS06955	COG0504	CTP synthase activity
PAZ_RS06970	COG0497	DNA recombination
PAZ_RS06975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PAZ_RS06990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PAZ_RS06995	COG1122	ATPase activity
PAZ_RS07000	COG1268	BioY protein
PAZ_RS07005	COG0647	UMP catabolic process
PAZ_RS07030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PAZ_RS07045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PAZ_RS07050	COG0072	phenylalanine-tRNA ligase activity
PAZ_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PAZ_RS07055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PAZ_RS07065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PAZ_RS07070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PAZ_RS07075	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PAZ_RS07090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PAZ_RS07095	COG0140	phosphoribosyl-ATP diphosphatase activity
PAZ_RS07100	COG3201	nicotinamide mononucleotide transporter
PAZ_RS07115	COG0667	Aldo Keto reductase
PAZ_RS07120	COG0372	Belongs to the citrate synthase family
PAZ_RS07160	COG0792	nuclease activity
PAZ_RS07170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PAZ_RS07175	COG0681	Belongs to the peptidase S26 family
PAZ_RS07180	COG0335	large ribosomal subunit rRNA binding
PAZ_RS07190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PAZ_RS07195	COG1053	succinate dehydrogenase
PAZ_RS07205	COG0336	Belongs to the RNA methyltransferase TrmD family
PAZ_RS07210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PAZ_RS07215	COG1837	Belongs to the UPF0109 family
PAZ_RS07220	COG0228	four-way junction DNA binding
PAZ_RS07270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PAZ_RS07275	COG0571	ribonuclease III activity
PAZ_RS07280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PAZ_RS07300	COG0395	ABC-type sugar transport system, permease component
PAZ_RS07305	COG1609	Transcriptional regulator
PAZ_RS07355	COG4166	transmembrane transport
PAZ_RS07365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PAZ_RS07385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PAZ_RS07390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PAZ_RS07395	COG0028	Belongs to the TPP enzyme family
PAZ_RS07405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PAZ_RS07410	COG1185	polyribonucleotide nucleotidyltransferase activity
PAZ_RS07415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PAZ_RS07435	COG4175	Glycine betaine
PAZ_RS07435	COG0517	IMP dehydrogenase activity
PAZ_RS07440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PAZ_RS07470	COG3732	PTS system glucitol sorbitol-specific
PAZ_RS07485	COG0371	Dehydrogenase
PAZ_RS07490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PAZ_RS07505	COG1131	(ABC) transporter
PAZ_RS07510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PAZ_RS07515	COG0195	Participates in both transcription termination and antitermination
PAZ_RS07520	COG0779	Required for maturation of 30S ribosomal subunits
PAZ_RS07530	COG0730	response to heat
PAZ_RS07540	COG0442	prolyl-tRNA aminoacylation
PAZ_RS07550	COG0803	Belongs to the bacterial solute-binding protein 9 family
PAZ_RS07550	COG0803	Belongs to the bacterial solute-binding protein 9 family
PAZ_RS07560	COG1121	(ABC) transporter
PAZ_RS07565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PAZ_RS07575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PAZ_RS07590	COG0750	zinc metalloprotease
PAZ_RS07595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PAZ_RS07610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PAZ_RS07615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PAZ_RS07620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PAZ_RS07630	COG0575	Belongs to the CDS family
PAZ_RS07635	COG0233	cytoplasmic translational termination
PAZ_RS07640	COG0528	UMP kinase activity
PAZ_RS07645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PAZ_RS07650	COG0052	Belongs to the universal ribosomal protein uS2 family
PAZ_RS07655	COG4974	Belongs to the 'phage' integrase family
PAZ_RS07670	COG0242	peptide deformylase activity
PAZ_RS07695	COG1119	ATPase activity
PAZ_RS07705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PAZ_RS07725	COG2226	methyltransferase
PAZ_RS07735	COG0488	(ABC) transporter
PAZ_RS07765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PAZ_RS07770	COG0396	ATPase activity
PAZ_RS07785	COG0719	Fe-S assembly protein
PAZ_RS07800	COG1175	transmembrane transport
PAZ_RS07805	COG0395	ABC-type sugar transport system, permease component
PAZ_RS07810	COG3833	ABC-type maltose transport systems, permease component
PAZ_RS07820	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PAZ_RS07825	COG1131	(ABC) transporter
PAZ_RS07845	COG0109	protoheme IX farnesyltransferase activity
PAZ_RS07865	COG0363	glucosamine-6-phosphate deaminase activity
PAZ_RS07880	COG0525	valine-tRNA ligase activity
PAZ_RS07885	COG1470	cell adhesion involved in biofilm formation
PAZ_RS07885	COG0366	Alpha amylase catalytic
PAZ_RS07890	COG4946	Tricorn protease homolog
PAZ_RS07890	COG0793	Belongs to the peptidase S41A family
PAZ_RS07895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PAZ_RS07900	COG0740	serine-type endopeptidase activity
PAZ_RS07905	COG0740	serine-type endopeptidase activity
PAZ_RS07915	COG0544	peptidyl-prolyl cis-trans isomerase activity
PAZ_RS07940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PAZ_RS07980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PAZ_RS07980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PAZ_RS08000	COG0698	ribose 5-phosphate isomerase
PAZ_RS08005	COG4552	Acetyltransferase involved in intracellular survival and related
PAZ_RS08010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PAZ_RS08030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PAZ_RS08065	COG1695	Transcriptional regulator
PAZ_RS08080	COG0629	single-stranded DNA binding
PAZ_RS08110	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PAZ_RS08120	COG1113	amino acid transport
PAZ_RS08125	COG0515	serine threonine protein kinase
PAZ_RS08130	COG1472	Belongs to the glycosyl hydrolase 3 family
PAZ_RS08160	COG0587	DNA-directed DNA polymerase activity
PAZ_RS08180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PAZ_RS08195	COG1653	transport
PAZ_RS08280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PAZ_RS08290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PAZ_RS08295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PAZ_RS08300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PAZ_RS08305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PAZ_RS08330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PAZ_RS08360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PAZ_RS08375	COG2835	tetraacyldisaccharide 4'-kinase activity
PAZ_RS08410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PAZ_RS08410	COG0662	Cupin 2, conserved barrel domain protein
PAZ_RS08430	COG1316	TRANSCRIPTIONal
PAZ_RS08455	COG3340	Belongs to the peptidase S51 family
PAZ_RS08470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PAZ_RS08480	COG0424	maF-like protein
PAZ_RS08495	COG4221	oxidoreductase activity
PAZ_RS08500	COG0351	phosphomethylpyrimidine kinase
PAZ_RS08515	COG0598	Magnesium transport protein CorA
PAZ_RS08525	COG4770	biotin carboxylase activity
PAZ_RS08545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PAZ_RS08550	COG0318	PFAM AMP-dependent synthetase and ligase
PAZ_RS08570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PAZ_RS08575	COG0328	RNA-DNA hybrid ribonuclease activity
PAZ_RS08585	COG1079	Belongs to the binding-protein-dependent transport system permease family
PAZ_RS08590	COG4603	Belongs to the binding-protein-dependent transport system permease family
PAZ_RS08595	COG3845	ABC transporter
PAZ_RS08600	COG1744	ABC transporter substrate-binding protein PnrA-like
PAZ_RS08610	COG1253	flavin adenine dinucleotide binding
PAZ_RS08630	COG0039	L-malate dehydrogenase activity
PAZ_RS08635	COG1012	belongs to the aldehyde dehydrogenase family
PAZ_RS08645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PAZ_RS08665	COG0138	bifunctional purine biosynthesis protein purh
PAZ_RS08675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PAZ_RS08680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PAZ_RS08680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PAZ_RS08690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PAZ_RS08690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PAZ_RS08705	COG0045	succinate-CoA ligase (ADP-forming) activity
PAZ_RS08720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PAZ_RS08725	COG2011	ABC-type metal ion transport system permease component
PAZ_RS08730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PAZ_RS08735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PAZ_RS08750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PAZ_RS08750	COG0519	Catalyzes the synthesis of GMP from XMP
PAZ_RS08760	COG1045	serine acetyltransferase
PAZ_RS08765	COG1605	Chorismate mutase
PAZ_RS08765	COG0287	Prephenate dehydrogenase
PAZ_RS08770	COG0516	GMP reductase activity
PAZ_RS08785	COG1115	amino acid carrier protein
PAZ_RS08795	COG0459	protein refolding
PAZ_RS08800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PAZ_RS08825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PAZ_RS08830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAZ_RS08845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PAZ_RS08850	COG0456	acetyltransferase
PAZ_RS08855	COG1214	PFAM Peptidase M22, glycoprotease
PAZ_RS08855	COG0456	acetyltransferase
PAZ_RS08860	COG0802	atpase or kinase
PAZ_RS08870	COG0513	Belongs to the DEAD box helicase family
PAZ_RS08880	COG1136	(ABC) transporter
PAZ_RS08885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PAZ_RS08885	COG0438	transferase activity, transferring glycosyl groups
PAZ_RS08895	COG0736	holo-[acyl-carrier-protein] synthase activity
PAZ_RS08900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PAZ_RS08915	COG1072	(Pantothenic acid kinase))
PAZ_RS08925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PAZ_RS08930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PAZ_RS08935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PAZ_RS08965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PAZ_RS08970	COG0101	tRNA pseudouridine synthase activity
PAZ_RS08985	COG3845	ABC transporter
PAZ_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
PAZ_RS09020	COG2271	Major facilitator Superfamily
PAZ_RS09030	COG0438	transferase activity, transferring glycosyl groups
PAZ_RS09035	COG0203	ribosomal protein L17
PAZ_RS09040	COG0202	RNA polymerase activity
PAZ_RS09045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PAZ_RS09050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PAZ_RS09055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PAZ_RS09060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PAZ_RS09065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PAZ_RS09075	COG0563	adenylate kinase activity
PAZ_RS09095	COG0584	glycerophosphoryl diester phosphodiesterase
PAZ_RS09110	COG0200	Binds to the 23S rRNA
PAZ_RS09115	COG1841	ribosomal large subunit assembly
PAZ_RS09120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PAZ_RS09125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PAZ_RS09130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PAZ_RS09135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PAZ_RS09140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PAZ_RS09145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PAZ_RS09150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PAZ_RS09155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PAZ_RS09160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PAZ_RS09165	COG0255	Belongs to the universal ribosomal protein uL29 family
PAZ_RS09170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PAZ_RS09175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PAZ_RS09180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PAZ_RS09185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PAZ_RS09190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PAZ_RS09195	COG0089	rRNA binding
PAZ_RS09200	COG0088	Forms part of the polypeptide exit tunnel
PAZ_RS09205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PAZ_RS09210	COG0051	transcription antitermination factor activity, RNA binding
PAZ_RS09220	COG0156	8-amino-7-oxononanoate synthase activity
PAZ_RS09235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PAZ_RS09240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PAZ_RS09250	COG0737	Belongs to the 5'-nucleotidase family
PAZ_RS09260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PAZ_RS09275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PAZ_RS09280	COG0049	tRNA binding
PAZ_RS09285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PAZ_RS09305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PAZ_RS09310	COG0085	RNA polymerase activity
PAZ_RS09315	COG0222	ribosome binding
PAZ_RS09320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PAZ_RS09325	COG0081	regulation of translation
PAZ_RS09330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PAZ_RS09335	COG0250	Participates in transcription elongation, termination and antitermination
PAZ_RS09340	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PAZ_RS09350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PAZ_RS09355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PAZ_RS09365	COG2030	dehydratase
PAZ_RS09370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PAZ_RS09390	COG0708	Exodeoxyribonuclease III
PAZ_RS09395	COG1024	Enoyl-CoA hydratase
PAZ_RS09405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAZ_RS09410	COG0649	NAD binding
PAZ_RS09415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAZ_RS09420	COG0674	pyruvate-flavodoxin oxidoreductase activity
PAZ_RS09420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PAZ_RS09425	COG1013	pyruvate-flavodoxin oxidoreductase activity
PAZ_RS09455	COG3590	peptidase
PAZ_RS09465	COG1126	abc transporter atp-binding protein
PAZ_RS09480	COG1131	(ABC) transporter
PAZ_RS09500	COG2301	Belongs to the HpcH HpaI aldolase family
PAZ_RS09510	COG0142	geranyltranstransferase activity
PAZ_RS09515	COG1007	ATP synthesis coupled electron transport
PAZ_RS09530	COG0713	ATP synthesis coupled electron transport
PAZ_RS09540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAZ_RS09545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PAZ_RS09550	COG1034	ATP synthesis coupled electron transport
PAZ_RS09555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PAZ_RS09565	COG0649	NAD binding
PAZ_RS09570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAZ_RS09575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAZ_RS09585	COG0644	oxidoreductase
PAZ_RS09610	COG2226	methyltransferase
PAZ_RS09625	COG1132	(ABC) transporter
PAZ_RS09635	COG1136	(ABC) transporter
PAZ_RS09655	COG2376	Dihydroxyacetone kinase
PAZ_RS09660	COG1461	Dihydroxyacetone kinase
PAZ_RS09665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAZ_RS09665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PAZ_RS09665	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
PAZ_RS09675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PAZ_RS09685	COG0039	L-malate dehydrogenase activity
PAZ_RS09720	COG0395	ABC-type sugar transport system, permease component
PAZ_RS09755	COG0395	ABC-type sugar transport system, permease component
PAZ_RS09760	COG1175	transmembrane transport
PAZ_RS09780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PAZ_RS09795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PAZ_RS09820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PAZ_RS09870	COG0047	phosphoribosylformylglycinamidine synthase activity
PAZ_RS09875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PAZ_RS09895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PAZ_RS09900	COG0151	Belongs to the GarS family
PAZ_RS09905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PAZ_RS09915	COG2188	Transcriptional regulator
PAZ_RS09920	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PAZ_RS09925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PAZ_RS09945	COG1217	gtp-binding protein TYPA
PAZ_RS09975	COG0840	transmembrane signaling receptor activity
PAZ_RS09985	COG0191	fructose-bisphosphate aldolase activity
PAZ_RS10000	COG0586	Pfam SNARE associated Golgi protein
PAZ_RS10020	COG3012	SEC-C Motif Domain Protein
PAZ_RS10025	COG0477	Major facilitator Superfamily
PAZ_RS10030	COG0542	response to heat
PAZ_RS10045	COG3588	fructose-bisphosphate aldolase
PAZ_RS10060	COG4585	Histidine kinase
PAZ_RS10065	COG2197	response regulator
PAZ_RS10070	COG4591	ABC-type transport system involved in lipoprotein release permease component
PAZ_RS10070	COG1136	(ABC) transporter
PAZ_RS10075	COG0577	efflux transmembrane transporter activity
PAZ_RS10075	COG1136	(ABC) transporter
PAZ_RS10080	COG1051	belongs to the nudix hydrolase family
PAZ_RS10085	COG1113	amino acid transport
PAZ_RS10090	COG0569	domain protein
PAZ_RS10090	COG2985	domain, Protein
PAZ_RS10095	COG1063	alcohol dehydrogenase
PAZ_RS10105	COG0789	Transcriptional regulator
PAZ_RS10110	COG0484	heat shock protein binding
PAZ_RS10115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PAZ_RS10135	COG0745	RESPONSE REGULATOR receiver
PAZ_RS10145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PAZ_RS10160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PAZ_RS10160	COG0574	Belongs to the PEP-utilizing enzyme family
PAZ_RS10165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PAZ_RS10175	COG0560	Phosphoserine phosphatase
PAZ_RS10175	COG3830	Belongs to the UPF0237 family
PAZ_RS10180	COG0676	glucose-6-phosphate 1-epimerase activity
PAZ_RS10245	COG0662	Cupin 2, conserved barrel domain protein
PAZ_RS10260	COG1132	(ABC) transporter
PAZ_RS10260	COG2375	cellular response to nickel ion
PAZ_RS10290	COG1131	(ABC) transporter
PAZ_RS10300	COG0508	dehydrogenase complex catalyzes the overall conversion of
PAZ_RS10305	COG0022	dehydrogenase e1 component
PAZ_RS10315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PAZ_RS10320	COG0535	radical SAM domain protein
PAZ_RS10340	COG1132	(ABC) transporter
PAZ_RS10360	COG2378	regulation of single-species biofilm formation
PAZ_RS10400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PAZ_RS10415	COG2205	protein histidine kinase activity
PAZ_RS10430	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
PAZ_RS10445	COG1902	pentaerythritol trinitrate reductase activity
PAZ_RS10455	COG0477	Major facilitator Superfamily
PAZ_RS10460	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PAZ_RS10460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PAZ_RS10465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PAZ_RS10485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PAZ_RS10490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PAZ_RS10500	COG0018	arginyl-trna synthetase
PAZ_RS10505	COG0656	L-ascorbic acid biosynthetic process
PAZ_RS10515	COG0166	Belongs to the GPI family
PAZ_RS10530	COG0783	Belongs to the Dps family
PAZ_RS10535	COG4581	dead DEAH box helicase
PAZ_RS10540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PAZ_RS10595	COG0701	Predicted permease
PAZ_RS10615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PAZ_RS10620	COG1408	metallophosphoesterase
PAZ_RS10630	COG0693	protein deglycase activity
PAZ_RS10635	COG0747	negative chemotaxis
PAZ_RS10640	COG0601	transmembrane transport
PAZ_RS10645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PAZ_RS10655	COG4608	Belongs to the ABC transporter superfamily
PAZ_RS10660	COG0254	rRNA binding
PAZ_RS10665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PAZ_RS10670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PAZ_RS10675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PAZ_RS10690	COG1472	Belongs to the glycosyl hydrolase 3 family
PAZ_RS10695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PAZ_RS10700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PAZ_RS10710	COG1228	amidohydrolase
PAZ_RS10715	COG2986	histidine ammonia-lyase
PAZ_RS10720	COG1518	maintenance of DNA repeat elements
PAZ_RS10745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PAZ_RS10765	COG3263	regulation of cellular component size
PAZ_RS10795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PAZ_RS10815	COG3158	transport of potassium into the cell
PAZ_RS10820	COG0505	Belongs to the CarA family
PAZ_RS10845	COG1609	Transcriptional regulator
PAZ_RS10850	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PAZ_RS10890	COG0137	argininosuccinate synthase activity
PAZ_RS10915	COG0561	phosphatase activity
PAZ_RS10955	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PAZ_RS10960	COG0644	oxidoreductase
PAZ_RS11000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PAZ_RS11015	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PAZ_RS11030	COG1968	undecaprenyl-diphosphatase activity
PAZ_RS11035	COG1528	Iron-storage protein
PAZ_RS11050	COG0359	binds to the 23S rRNA
PAZ_RS11055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PAZ_RS11065	COG0360	Binds together with S18 to 16S ribosomal RNA
PAZ_RS11075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS11075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS11075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAZ_RS11080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS11080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAZ_RS11080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PAZ_RS11090	COG1022	Amp-dependent synthetase and ligase
PAZ_RS11095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PAZ_RS11115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PAZ_RS11125	COG2608	mercury ion transmembrane transporter activity
PAZ_RS11130	COG1937	Protein conserved in bacteria
PAZ_RS11135	COG0305	Participates in initiation and elongation during chromosome replication
PAZ_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
PAZ_RS11140	COG0604	alcohol dehydrogenase
PAZ_RS11140	COG3321	synthase
PAZ_RS11150	COG2094	Belongs to the DNA glycosylase MPG family
PAZ_RS11165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PAZ_RS11170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PAZ_RS11185	COG1113	amino acid transport
PAZ_RS11205	COG0534	Mate efflux family protein
PAZ_RS11245	COG0205	6-phosphofructokinase activity
PAZ_RS11250	COG0686	Belongs to the AlaDH PNT family
PAZ_RS11255	COG1113	amino acid transport
PAZ_RS11265	COG1376	ErfK ybiS ycfS ynhG family protein
PAZ_RS11270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PAZ_RS11280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PAZ_RS11285	COG0686	Belongs to the AlaDH PNT family
PAZ_RS11320	COG5012	cobalamin binding
PAZ_RS11330	COG3457	Alanine racemase
PAZ_RS11335	COG1113	amino acid transport
PAZ_RS11340	COG1113	amino acid transport
PAZ_RS11345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PAZ_RS11350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PAZ_RS11355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PAZ_RS11375	COG0114	fumarate hydratase activity
PAZ_RS11380	COG0395	ABC-type sugar transport system, permease component
PAZ_RS11385	COG1175	transmembrane transport
PAZ_RS11405	COG0668	transmembrane transport
PAZ_RS11410	COG1929	Belongs to the glycerate kinase type-1 family
PAZ_RS11420	COG0617	tRNA 3'-terminal CCA addition
PAZ_RS11430	COG0515	serine threonine protein kinase
PAZ_RS11435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PAZ_RS11440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PAZ_RS11450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PAZ_RS11460	COG0492	ferredoxin-NADP+ reductase activity
PAZ_RS11475	COG0657	acetylesterase activity
PAZ_RS11485	COG3118	belongs to the thioredoxin family
PAZ_RS11515	COG0371	Dehydrogenase
PAZ_RS11535	COG0698	ribose 5-phosphate isomerase
PAZ_RS11545	COG1349	DNA-binding transcription factor activity
PAZ_RS11550	COG1312	Catalyzes the dehydration of D-mannonate
PAZ_RS11555	COG0246	Mannitol dehydrogenase
PAZ_RS11560	COG1904	glucuronate isomerase
PAZ_RS11565	COG1609	Transcriptional regulator
PAZ_RS11570	COG2211	Major facilitator Superfamily
PAZ_RS11585	COG3250	beta-galactosidase activity
PAZ_RS11600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PAZ_RS11605	COG1181	Belongs to the D-alanine--D-alanine ligase family
PAZ_RS11615	COG2814	Major facilitator Superfamily
PAZ_RS11620	COG1475	DNA binding
PAZ_RS11635	COG0357	Ribosomal RNA small subunit methyltransferase G
PAZ_RS11660	COG0706	membrane insertase activity
PAZ_RS11670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PAZ_RS11740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PAZ_RS11795	COG0438	transferase activity, transferring glycosyl groups
PAZ_RS11945	COG1854	S-ribosylhomocysteine lyase activity
PAZ_RS11995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PAZ_RS12145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PAZ_RS12205	COG0667	Aldo Keto reductase
PAZ_RS12340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PAZ_RS12430	COG0473	3-isopropylmalate dehydrogenase activity
PAZ_RS12905	COG1609	Transcriptional regulator
PAZ_RS12970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PAZ_RS12975	COG0594	ribonuclease P activity
PAZ_RS12985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PAZ_RS12985	COG3253	May function as heme-dependent peroxidase
PAZ_RS12990	COG3253	May function as heme-dependent peroxidase
PAZ_RS12990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PAZ_RS13040	COG1136	(ABC) transporter
PAZ_RS13080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity