locus-tag	class	description
HMPREF0675_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HMPREF0675_RS00010	COG0592	DNA-directed DNA polymerase activity
HMPREF0675_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF0675_RS00045	COG1482	cell wall glycoprotein biosynthetic process
HMPREF0675_RS00050	COG0187	DNA topoisomerase II activity
HMPREF0675_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0675_RS00060	COG3266	domain, Protein
HMPREF0675_RS00065	COG0039	L-malate dehydrogenase activity
HMPREF0675_RS00070	COG1609	Transcriptional regulator
HMPREF0675_RS00075	COG1129	ABC transporter
HMPREF0675_RS00080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF0675_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF0675_RS00095	COG1869	D-ribose catabolic process
HMPREF0675_RS00120	COG3414	Phosphotransferase system galactitol-specific IIB component
HMPREF0675_RS00125	COG1063	alcohol dehydrogenase
HMPREF0675_RS00165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPREF0675_RS00235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HMPREF0675_RS00255	COG4591	ABC-type transport system involved in lipoprotein release permease component
HMPREF0675_RS00260	COG0577	efflux transmembrane transporter activity
HMPREF0675_RS00260	COG1136	(ABC) transporter
HMPREF0675_RS00265	COG2197	response regulator
HMPREF0675_RS00275	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS00280	COG1175	transmembrane transport
HMPREF0675_RS00290	COG1349	DNA-binding transcription factor activity
HMPREF0675_RS00310	COG0546	phosphoglycolate phosphatase activity
HMPREF0675_RS00320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HMPREF0675_RS00330	COG4585	Histidine kinase
HMPREF0675_RS00340	COG1309	transcriptional regulator
HMPREF0675_RS00345	COG2409	Drug exporters of the RND superfamily
HMPREF0675_RS00365	COG1136	(ABC) transporter
HMPREF0675_RS00380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0675_RS00400	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF0675_RS00415	COG5426	von Willebrand factor, type A
HMPREF0675_RS00430	COG1175	transmembrane transport
HMPREF0675_RS00435	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS00460	COG0205	6-phosphofructokinase activity
HMPREF0675_RS00480	COG1027	Aspartate ammonia-lyase
HMPREF0675_RS00485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HMPREF0675_RS00500	COG1132	(ABC) transporter
HMPREF0675_RS00505	COG1132	(ABC) transporter
HMPREF0675_RS00510	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HMPREF0675_RS00525	COG0641	radical SAM
HMPREF0675_RS00530	COG1120	ATPase activity
HMPREF0675_RS00545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPREF0675_RS00555	COG4716	Myosin-crossreactive antigen
HMPREF0675_RS00560	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF0675_RS00560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF0675_RS00560	COG0351	phosphomethylpyrimidine kinase
HMPREF0675_RS00565	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF0675_RS00585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HMPREF0675_RS00595	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HMPREF0675_RS00620	COG0488	(ABC) transporter
HMPREF0675_RS00675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0675_RS00705	COG0438	transferase activity, transferring glycosyl groups
HMPREF0675_RS00740	COG3104	oligopeptide transport
HMPREF0675_RS00750	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0675_RS00760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS00760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS00765	COG1105	Belongs to the carbohydrate kinase PfkB family
HMPREF0675_RS00775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HMPREF0675_RS00795	COG0297	glycogen (starch) synthase activity
HMPREF0675_RS00815	COG1252	NADH dehydrogenase
HMPREF0675_RS00825	COG1643	Atp-dependent helicase
HMPREF0675_RS00845	COG1192	Involved in chromosome partitioning
HMPREF0675_RS00915	COG1131	(ABC) transporter
HMPREF0675_RS00960	COG1643	Atp-dependent helicase
HMPREF0675_RS00965	COG4721	ABC-type cobalt transport system, permease component
HMPREF0675_RS00970	COG1129	ABC transporter
HMPREF0675_RS00990	COG0167	dihydroorotate dehydrogenase activity
HMPREF0675_RS00995	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HMPREF0675_RS00995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPREF0675_RS00995	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPREF0675_RS00995	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPREF0675_RS01010	COG2186	Transcriptional regulator
HMPREF0675_RS01015	COG1620	l-lactate permease
HMPREF0675_RS01020	COG0247	lactate metabolic process
HMPREF0675_RS01025	COG1139	Iron-sulfur cluster binding protein
HMPREF0675_RS01030	COG1556	Lactate utilization protein
HMPREF0675_RS01035	COG1122	ATPase activity
HMPREF0675_RS01050	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HMPREF0675_RS01055	COG4988	ABC transporter
HMPREF0675_RS01060	COG1294	oxidase, subunit
HMPREF0675_RS01065	COG1271	oxidase subunit
HMPREF0675_RS01095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF0675_RS01110	COG2815	serine threonine protein kinase
HMPREF0675_RS01110	COG0515	serine threonine protein kinase
HMPREF0675_RS01115	COG0768	penicillin binding
HMPREF0675_RS01130	COG1716	ATPase activity
HMPREF0675_RS01235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HMPREF0675_RS01240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMPREF0675_RS01250	COG1136	(ABC) transporter
HMPREF0675_RS01250	COG0577	efflux transmembrane transporter activity
HMPREF0675_RS01265	COG0561	phosphatase activity
HMPREF0675_RS01270	COG0561	phosphatase activity
HMPREF0675_RS01275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HMPREF0675_RS01280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF0675_RS01290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMPREF0675_RS01295	COG3681	Belongs to the UPF0597 family
HMPREF0675_RS01300	COG0814	amino acid
HMPREF0675_RS01310	COG0673	inositol 2-dehydrogenase activity
HMPREF0675_RS01345	COG0494	nUDIX hydrolase
HMPREF0675_RS01355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HMPREF0675_RS01410	COG1111	helicase
HMPREF0675_RS01410	COG1205	dead DEAH box helicase
HMPREF0675_RS01415	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF0675_RS01425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF0675_RS01425	COG1754	DNA topoisomerase type I activity
HMPREF0675_RS01435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMPREF0675_RS01440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF0675_RS01450	COG1774	PSP1 C-terminal conserved region
HMPREF0675_RS01475	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HMPREF0675_RS01490	COG3458	cephalosporin-C deacetylase activity
HMPREF0675_RS01500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HMPREF0675_RS01510	COG0037	tRNA processing
HMPREF0675_RS01525	COG0302	gtp cyclohydrolase
HMPREF0675_RS01565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMPREF0675_RS01570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMPREF0675_RS01590	COG0649	NAD binding
HMPREF0675_RS01620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HMPREF0675_RS01625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HMPREF0675_RS01630	COG1984	allophanate hydrolase subunit 2
HMPREF0675_RS01640	COG1090	epimerase
HMPREF0675_RS01645	COG0705	Rhomboid family
HMPREF0675_RS01655	COG2197	response regulator
HMPREF0675_RS01660	COG4585	Histidine kinase
HMPREF0675_RS01670	COG3711	transcriptional antiterminator
HMPREF0675_RS01675	COG1263	PTS System
HMPREF0675_RS01675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0675_RS01675	COG2190	(PTS) system
HMPREF0675_RS01680	COG2190	(PTS) system
HMPREF0675_RS01680	COG1263	PTS System
HMPREF0675_RS01680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0675_RS01695	COG1194	a g-specific adenine glycosylase
HMPREF0675_RS01700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HMPREF0675_RS01705	COG0113	porphobilinogen synthase activity
HMPREF0675_RS01715	COG0181	hydroxymethylbilane synthase activity
HMPREF0675_RS01725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HMPREF0675_RS01730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HMPREF0675_RS01735	COG3253	May function as heme-dependent peroxidase
HMPREF0675_RS01735	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HMPREF0675_RS01745	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HMPREF0675_RS01750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF0675_RS01765	COG1082	Xylose isomerase domain protein TIM barrel
HMPREF0675_RS01770	COG0506	proline dehydrogenase activity
HMPREF0675_RS01785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF0675_RS01805	COG0406	alpha-ribazole phosphatase activity
HMPREF0675_RS01810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0675_RS01815	COG0785	Cytochrome C biogenesis protein
HMPREF0675_RS01820	COG1333	cytochrome c biogenesis protein
HMPREF0675_RS01825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HMPREF0675_RS01835	COG4221	oxidoreductase activity
HMPREF0675_RS01860	COG1120	ATPase activity
HMPREF0675_RS01865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0675_RS01875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF0675_RS01895	COG0494	nUDIX hydrolase
HMPREF0675_RS01895	COG0406	alpha-ribazole phosphatase activity
HMPREF0675_RS01900	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HMPREF0675_RS01905	COG0745	RESPONSE REGULATOR receiver
HMPREF0675_RS01915	COG1490	D-aminoacyl-tRNA deacylase activity
HMPREF0675_RS01920	COG3485	protocatechuate 3,4-dioxygenase
HMPREF0675_RS01930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPREF0675_RS01940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF0675_RS01945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0675_RS01950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HMPREF0675_RS01955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HMPREF0675_RS01970	COG1329	Transcriptional regulator
HMPREF0675_RS02005	COG0588	phosphoglycerate mutase activity
HMPREF0675_RS02020	COG0252	asparaginase activity
HMPREF0675_RS02025	COG1113	amino acid transport
HMPREF0675_RS02030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMPREF0675_RS02035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF0675_RS02040	COG0800	Aldolase
HMPREF0675_RS02050	COG5492	domain, Protein
HMPREF0675_RS02070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF0675_RS02075	COG0215	cysteine-tRNA ligase activity
HMPREF0675_RS02130	COG3842	ATPase activity
HMPREF0675_RS02140	COG1760	l-serine dehydratase
HMPREF0675_RS02145	COG0673	inositol 2-dehydrogenase activity
HMPREF0675_RS02150	COG2182	Extracellular solute-binding protein
HMPREF0675_RS02155	COG1175	transmembrane transport
HMPREF0675_RS02160	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS02165	COG1063	alcohol dehydrogenase
HMPREF0675_RS02180	COG1174	glycine betaine transport
HMPREF0675_RS02205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HMPREF0675_RS02210	COG2130	NADP-dependent
HMPREF0675_RS02215	COG1131	(ABC) transporter
HMPREF0675_RS02225	COG4585	Histidine kinase
HMPREF0675_RS02230	COG2197	response regulator
HMPREF0675_RS02235	COG0406	alpha-ribazole phosphatase activity
HMPREF0675_RS02240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HMPREF0675_RS02245	COG1492	cobalamin metabolic process
HMPREF0675_RS02265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMPREF0675_RS02265	COG1648	precorrin-2 dehydrogenase activity
HMPREF0675_RS02280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0675_RS02285	COG1120	ATPase activity
HMPREF0675_RS02305	COG0310	cobalt ion transport
HMPREF0675_RS02340	COG1797	cobyrinic acid a,c-diamide synthase activity
HMPREF0675_RS02350	COG2099	Precorrin-6x reductase
HMPREF0675_RS02355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HMPREF0675_RS02385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS02385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS02385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0675_RS02400	COG1854	S-ribosylhomocysteine lyase activity
HMPREF0675_RS02420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMPREF0675_RS02430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF0675_RS02440	COG3718	enzyme involved in inositol metabolism
HMPREF0675_RS02445	COG3962	Belongs to the TPP enzyme family
HMPREF0675_RS02460	COG1609	Transcriptional regulator
HMPREF0675_RS02470	COG1082	Xylose isomerase domain protein TIM barrel
HMPREF0675_RS02480	COG0673	inositol 2-dehydrogenase activity
HMPREF0675_RS02485	COG2814	Major facilitator Superfamily
HMPREF0675_RS02495	COG1082	Xylose isomerase domain protein TIM barrel
HMPREF0675_RS02500	COG0673	inositol 2-dehydrogenase activity
HMPREF0675_RS02510	COG3142	Participates in the control of copper homeostasis
HMPREF0675_RS02520	COG1061	Type III restriction enzyme res subunit
HMPREF0675_RS02535	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF0675_RS02540	COG1278	Cold shock
HMPREF0675_RS02555	COG2252	PERMEase
HMPREF0675_RS02570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMPREF0675_RS02595	COG2814	Major facilitator Superfamily
HMPREF0675_RS02615	COG1970	mechanosensitive ion channel activity
HMPREF0675_RS02630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF0675_RS02635	COG0303	'Molybdopterin
HMPREF0675_RS02660	COG0315	cyclic pyranopterin monophosphate synthase activity
HMPREF0675_RS02680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HMPREF0675_RS02715	COG1140	nitrate reductase beta subunit
HMPREF0675_RS02735	COG0521	Mo-molybdopterin cofactor biosynthetic process
HMPREF0675_RS02735	COG0315	cyclic pyranopterin monophosphate synthase activity
HMPREF0675_RS02750	COG0437	4 iron, 4 sulfur cluster binding
HMPREF0675_RS02755	COG0243	molybdopterin cofactor binding
HMPREF0675_RS02765	COG2022	thiamine diphosphate biosynthetic process
HMPREF0675_RS02775	COG2022	thiamine diphosphate biosynthetic process
HMPREF0675_RS02775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMPREF0675_RS02780	COG0598	Magnesium transport protein CorA
HMPREF0675_RS02785	COG2233	PERMEase
HMPREF0675_RS02800	COG0084	hydrolase, TatD family'
HMPREF0675_RS02805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMPREF0675_RS02810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HMPREF0675_RS02815	COG1846	Transcriptional regulator
HMPREF0675_RS02830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMPREF0675_RS02835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF0675_RS02855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HMPREF0675_RS02860	COG0193	aminoacyl-tRNA hydrolase activity
HMPREF0675_RS02910	COG0148	phosphopyruvate hydratase activity
HMPREF0675_RS02975	COG1297	OPT oligopeptide transporter protein
HMPREF0675_RS02980	COG0667	Aldo Keto reductase
HMPREF0675_RS02985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0675_RS02990	COG0733	neurotransmitter:sodium symporter activity
HMPREF0675_RS02995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMPREF0675_RS03010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMPREF0675_RS03025	COG1331	Highly conserved protein containing a thioredoxin domain
HMPREF0675_RS03030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF0675_RS03040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HMPREF0675_RS03050	COG1722	exodeoxyribonuclease VII activity
HMPREF0675_RS03055	COG1570	exodeoxyribonuclease VII activity
HMPREF0675_RS03065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMPREF0675_RS03070	COG1322	Protein conserved in bacteria
HMPREF0675_RS03075	COG1362	aminopeptidase activity
HMPREF0675_RS03080	COG0012	GTP binding
HMPREF0675_RS03100	COG1846	Transcriptional regulator
HMPREF0675_RS03105	COG1764	response to oxidative stress
HMPREF0675_RS03120	COG2235	arginine
HMPREF0675_RS03125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMPREF0675_RS03145	COG3830	Belongs to the UPF0237 family
HMPREF0675_RS03150	COG0667	Aldo Keto reductase
HMPREF0675_RS03155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HMPREF0675_RS03160	COG0833	amino acid
HMPREF0675_RS03165	COG3103	Sh3 type 3 domain protein
HMPREF0675_RS03165	COG0366	Alpha amylase catalytic
HMPREF0675_RS03205	COG1404	Belongs to the peptidase S8 family
HMPREF0675_RS03210	COG2501	S4 domain
HMPREF0675_RS03215	COG1126	abc transporter atp-binding protein
HMPREF0675_RS03230	COG1609	Transcriptional regulator
HMPREF0675_RS03245	COG1176	ABC-type spermidine putrescine transport system, permease component I
HMPREF0675_RS03250	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS03260	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HMPREF0675_RS03280	COG1136	(ABC) transporter
HMPREF0675_RS03290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF0675_RS03300	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0675_RS03315	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0675_RS03320	COG1063	alcohol dehydrogenase
HMPREF0675_RS03325	COG2376	Dihydroxyacetone kinase
HMPREF0675_RS03330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HMPREF0675_RS03340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HMPREF0675_RS03345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HMPREF0675_RS03350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HMPREF0675_RS03365	COG2171	N-acyltransferase activity
HMPREF0675_RS03370	COG1834	amidinotransferase
HMPREF0675_RS03380	COG0477	Major facilitator Superfamily
HMPREF0675_RS03405	COG0297	glycogen (starch) synthase activity
HMPREF0675_RS03410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF0675_RS03420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF0675_RS03425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPREF0675_RS03460	COG0006	proline dipeptidase activity
HMPREF0675_RS03485	COG4139	cobalamin transport
HMPREF0675_RS03490	COG1120	ATPase activity
HMPREF0675_RS03505	COG1966	Carbon starvation protein
HMPREF0675_RS03525	COG0174	glutamine synthetase
HMPREF0675_RS03535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HMPREF0675_RS03540	COG2966	Psort location CytoplasmicMembrane, score
HMPREF0675_RS03560	COG0174	glutamine synthetase
HMPREF0675_RS03570	COG0438	transferase activity, transferring glycosyl groups
HMPREF0675_RS03580	COG1263	PTS System
HMPREF0675_RS03585	COG2188	Transcriptional regulator
HMPREF0675_RS03590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0675_RS03590	COG1263	PTS System
HMPREF0675_RS03595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0675_RS03605	COG3477	response to acidic pH
HMPREF0675_RS03615	COG0488	(ABC) transporter
HMPREF0675_RS03650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HMPREF0675_RS03665	COG0321	lipoyl(octanoyl) transferase activity
HMPREF0675_RS03670	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF0675_RS03675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMPREF0675_RS03710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HMPREF0675_RS03715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMPREF0675_RS03760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HMPREF0675_RS03765	COG0723	plastoquinol--plastocyanin reductase activity
HMPREF0675_RS03770	COG2010	Cytochrome c
HMPREF0675_RS03775	COG1845	cytochrome c oxidase, subunit III
HMPREF0675_RS03785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMPREF0675_RS03800	COG0088	Forms part of the polypeptide exit tunnel
HMPREF0675_RS03805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMPREF0675_RS03825	COG1940	carbohydrate kinase activity
HMPREF0675_RS03845	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HMPREF0675_RS03850	COG1234	tRNA 3'-trailer cleavage
HMPREF0675_RS03860	COG2815	serine threonine protein kinase
HMPREF0675_RS03860	COG0515	serine threonine protein kinase
HMPREF0675_RS03875	COG0142	geranyltranstransferase activity
HMPREF0675_RS03885	COG0210	DNA helicase
HMPREF0675_RS03920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMPREF0675_RS03920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMPREF0675_RS03925	COG0509	glycine decarboxylation via glycine cleavage system
HMPREF0675_RS03930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HMPREF0675_RS03950	COG0714	Associated with various cellular activities
HMPREF0675_RS03955	COG2001	Belongs to the MraZ family
HMPREF0675_RS03960	COG0275	rRNA processing
HMPREF0675_RS03970	COG0768	penicillin binding
HMPREF0675_RS03975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF0675_RS03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF0675_RS03985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF0675_RS03990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMPREF0675_RS04000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMPREF0675_RS04005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HMPREF0675_RS04020	COG1496	oxidoreductase activity
HMPREF0675_RS04025	COG1799	cell septum assembly
HMPREF0675_RS04055	COG0469	pyruvate kinase activity
HMPREF0675_RS04060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMPREF0675_RS04065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMPREF0675_RS04105	COG0539	negative regulation of cytoplasmic translation
HMPREF0675_RS04120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0675_RS04125	COG1120	ATPase activity
HMPREF0675_RS04135	COG1132	(ABC) transporter
HMPREF0675_RS04140	COG1132	(ABC) transporter
HMPREF0675_RS04145	COG0237	dephospho-CoA kinase activity
HMPREF0675_RS04155	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HMPREF0675_RS04170	COG1429	ligase activity, forming nitrogen-metal bonds
HMPREF0675_RS04175	COG1120	ATPase activity
HMPREF0675_RS04180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0675_RS04215	COG0556	nucleotide-excision repair
HMPREF0675_RS04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMPREF0675_RS04255	COG0322	excinuclease ABC activity
HMPREF0675_RS04260	COG1660	Displays ATPase and GTPase activities
HMPREF0675_RS04265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPREF0675_RS04270	COG1481	regulation of sporulation
HMPREF0675_RS04275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HMPREF0675_RS04280	COG0126	phosphoglycerate kinase activity
HMPREF0675_RS04285	COG0149	triose-phosphate isomerase activity
HMPREF0675_RS04290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF0675_RS04300	COG0285	dihydrofolate synthase activity
HMPREF0675_RS04310	COG0105	UTP biosynthetic process
HMPREF0675_RS04325	COG1530	ribonuclease E activity
HMPREF0675_RS04330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HMPREF0675_RS04335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HMPREF0675_RS04345	COG1309	transcriptional regulator
HMPREF0675_RS04355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMPREF0675_RS04360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMPREF0675_RS04365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMPREF0675_RS04375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF0675_RS04385	COG0406	alpha-ribazole phosphatase activity
HMPREF0675_RS04420	COG0488	(ABC) transporter
HMPREF0675_RS04425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HMPREF0675_RS04440	COG1309	transcriptional regulator
HMPREF0675_RS04460	COG0577	efflux transmembrane transporter activity
HMPREF0675_RS04460	COG1136	(ABC) transporter
HMPREF0675_RS04470	COG2197	response regulator
HMPREF0675_RS04530	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HMPREF0675_RS04535	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HMPREF0675_RS04555	COG2814	Major facilitator Superfamily
HMPREF0675_RS04560	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HMPREF0675_RS04565	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF0675_RS04570	COG0039	L-malate dehydrogenase activity
HMPREF0675_RS04575	COG0281	malic enzyme
HMPREF0675_RS04600	COG0495	leucyl-tRNA aminoacylation
HMPREF0675_RS04605	COG1555	photosystem II stabilization
HMPREF0675_RS04605	COG1596	polysaccharide export
HMPREF0675_RS04625	COG0268	Binds directly to 16S ribosomal RNA
HMPREF0675_RS04635	COG0481	GTPase activity
HMPREF0675_RS04640	COG4948	Mandelate Racemase Muconate Lactonizing
HMPREF0675_RS04645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HMPREF0675_RS04650	COG1169	isochorismate synthase
HMPREF0675_RS04680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HMPREF0675_RS04685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HMPREF0675_RS04700	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF0675_RS04705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMPREF0675_RS04710	COG1420	regulation of RNA biosynthetic process
HMPREF0675_RS04715	COG0484	heat shock protein binding
HMPREF0675_RS04725	COG1063	alcohol dehydrogenase
HMPREF0675_RS04745	COG0514	ATP-dependent DNA helicase (RecQ)
HMPREF0675_RS04750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMPREF0675_RS04760	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF0675_RS04765	COG4585	Histidine kinase
HMPREF0675_RS04770	COG2197	response regulator
HMPREF0675_RS04775	COG4152	abc transporter atp-binding protein
HMPREF0675_RS04810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMPREF0675_RS04820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMPREF0675_RS04825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HMPREF0675_RS04830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HMPREF0675_RS04835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF0675_RS04845	COG1381	Involved in DNA repair and RecF pathway recombination
HMPREF0675_RS04860	COG2197	response regulator
HMPREF0675_RS04870	COG0423	glycine-tRNA ligase activity
HMPREF0675_RS04880	COG1053	succinate dehydrogenase
HMPREF0675_RS04890	COG0778	Nitroreductase
HMPREF0675_RS04910	COG0358	DNA primase activity
HMPREF0675_RS04915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF0675_RS04930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMPREF0675_RS04935	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HMPREF0675_RS04950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF0675_RS04955	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HMPREF0675_RS04960	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HMPREF0675_RS04965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HMPREF0675_RS04970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMPREF0675_RS04990	COG0561	phosphatase activity
HMPREF0675_RS05000	COG0714	Associated with various cellular activities
HMPREF0675_RS05035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF0675_RS05040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF0675_RS05060	COG2814	Major facilitator Superfamily
HMPREF0675_RS05070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HMPREF0675_RS05085	COG1335	isochorismatase
HMPREF0675_RS05090	COG0667	Aldo Keto reductase
HMPREF0675_RS05095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HMPREF0675_RS05100	COG0540	Belongs to the ATCase OTCase family
HMPREF0675_RS05105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF0675_RS05110	COG0505	Belongs to the CarA family
HMPREF0675_RS05115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HMPREF0675_RS05120	COG0543	2 iron, 2 sulfur cluster binding
HMPREF0675_RS05125	COG0167	dihydroorotate dehydrogenase activity
HMPREF0675_RS05130	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF0675_RS05135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMPREF0675_RS05145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF0675_RS05155	COG1058	Belongs to the CinA family
HMPREF0675_RS05155	COG1546	Belongs to the CinA family
HMPREF0675_RS05160	COG1396	sequence-specific DNA binding
HMPREF0675_RS05180	COG2137	regulation of response to DNA damage stimulus
HMPREF0675_RS05185	COG1418	mRNA catabolic process
HMPREF0675_RS05190	COG2017	converts alpha-aldose to the beta-anomer
HMPREF0675_RS05195	COG1288	antiporter activity
HMPREF0675_RS05200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF0675_RS05210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMPREF0675_RS05215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HMPREF0675_RS05220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF0675_RS05230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMPREF0675_RS05240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF0675_RS05245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0675_RS05260	COG1643	Atp-dependent helicase
HMPREF0675_RS05265	COG1946	Acyl-CoA thioesterase
HMPREF0675_RS05270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF0675_RS05275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF0675_RS05285	COG1309	transcriptional regulator
HMPREF0675_RS05325	COG0187	DNA topoisomerase II activity
HMPREF0675_RS05330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HMPREF0675_RS05340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0675_RS05360	COG1435	thymidine kinase activity
HMPREF0675_RS05385	COG0756	dUTP diphosphatase activity
HMPREF0675_RS05405	COG0569	domain protein
HMPREF0675_RS05410	COG0531	amino acid
HMPREF0675_RS05415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF0675_RS05425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HMPREF0675_RS05430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF0675_RS05445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0675_RS05455	COG2964	Protein conserved in bacteria
HMPREF0675_RS05465	COG1113	amino acid transport
HMPREF0675_RS05470	COG2326	polyphosphate kinase activity
HMPREF0675_RS05495	COG1064	alcohol dehydrogenase
HMPREF0675_RS05500	COG3850	Histidine kinase
HMPREF0675_RS05510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMPREF0675_RS05520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF0675_RS05545	COG0509	glycine decarboxylation via glycine cleavage system
HMPREF0675_RS05550	COG1716	ATPase activity
HMPREF0675_RS05570	COG1295	ribonuclease BN
HMPREF0675_RS05580	COG0205	6-phosphofructokinase activity
HMPREF0675_RS05590	COG0009	L-threonylcarbamoyladenylate synthase
HMPREF0675_RS05605	COG1739	Uncharacterized protein family UPF0029
HMPREF0675_RS05615	COG0443	Heat shock 70 kDa protein
HMPREF0675_RS05655	COG0033	Phosphoglucomutase
HMPREF0675_RS05665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF0675_RS05685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMPREF0675_RS05700	COG0366	Alpha amylase catalytic
HMPREF0675_RS05715	COG0482	sulfurtransferase activity
HMPREF0675_RS05740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF0675_RS05745	COG0154	amidase activity
HMPREF0675_RS05750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF0675_RS05760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HMPREF0675_RS05780	COG0134	indole-3-glycerol-phosphate synthase activity
HMPREF0675_RS05785	COG0133	tryptophan synthase activity
HMPREF0675_RS05795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMPREF0675_RS05800	COG0067	glutamate synthase
HMPREF0675_RS05800	COG0070	glutamate synthase
HMPREF0675_RS05800	COG0069	glutamate synthase activity
HMPREF0675_RS05815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HMPREF0675_RS05825	COG1737	Transcriptional regulator
HMPREF0675_RS05830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HMPREF0675_RS05845	COG2971	BadF BadG BcrA BcrD
HMPREF0675_RS05855	COG2723	6-phospho-beta-galactosidase activity
HMPREF0675_RS05860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0675_RS05865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0675_RS05870	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF0675_RS05890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HMPREF0675_RS05895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPREF0675_RS05900	COG0131	Imidazoleglycerol-phosphate dehydratase
HMPREF0675_RS05905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMPREF0675_RS05910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HMPREF0675_RS05915	COG0217	transcriptional regulatory protein
HMPREF0675_RS05920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HMPREF0675_RS05925	COG0632	four-way junction helicase activity
HMPREF0675_RS05930	COG2255	four-way junction helicase activity
HMPREF0675_RS05940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF0675_RS05945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF0675_RS05950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF0675_RS05960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF0675_RS05965	COG1196	nuclear chromosome segregation
HMPREF0675_RS05970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMPREF0675_RS05975	COG0124	histidyl-tRNA synthetase
HMPREF0675_RS06005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMPREF0675_RS06020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMPREF0675_RS06025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMPREF0675_RS06030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF0675_RS06035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF0675_RS06040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMPREF0675_RS06045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF0675_RS06050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMPREF0675_RS06065	COG2326	polyphosphate kinase activity
HMPREF0675_RS06070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMPREF0675_RS06075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF0675_RS06085	COG0194	GDP metabolic process
HMPREF0675_RS06090	COG1758	RNA polymerase activity
HMPREF0675_RS06100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMPREF0675_RS06110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMPREF0675_RS06130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF0675_RS06150	COG1511	domain protein
HMPREF0675_RS06155	COG1129	ABC transporter
HMPREF0675_RS06165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HMPREF0675_RS06170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HMPREF0675_RS06185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HMPREF0675_RS06190	COG1160	GTP binding
HMPREF0675_RS06200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF0675_RS06210	COG0738	Major facilitator superfamily
HMPREF0675_RS06215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF0675_RS06230	COG0427	acetyl-CoA hydrolase
HMPREF0675_RS06245	COG1522	sequence-specific DNA binding
HMPREF0675_RS06255	COG1216	Glycosyl transferase, family 2
HMPREF0675_RS06270	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HMPREF0675_RS06285	COG1230	cation diffusion facilitator family transporter
HMPREF0675_RS06305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF0675_RS06310	COG2814	Major facilitator Superfamily
HMPREF0675_RS06315	COG1846	Transcriptional regulator
HMPREF0675_RS06340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HMPREF0675_RS06345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMPREF0675_RS06350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMPREF0675_RS06355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMPREF0675_RS06360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF0675_RS06365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMPREF0675_RS06370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF0675_RS06375	COG0356	it plays a direct role in the translocation of protons across the membrane
HMPREF0675_RS06390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF0675_RS06400	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF0675_RS06405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMPREF0675_RS06410	COG0254	rRNA binding
HMPREF0675_RS06420	COG0083	homoserine kinase activity
HMPREF0675_RS06425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HMPREF0675_RS06430	COG0460	homoserine dehydrogenase
HMPREF0675_RS06450	COG0567	Dehydrogenase, E1 component
HMPREF0675_RS06450	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF0675_RS06480	COG1595	DNA-templated transcription, initiation
HMPREF0675_RS06490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HMPREF0675_RS06495	COG1162	GTPase activity
HMPREF0675_RS06505	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF0675_RS06510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF0675_RS06520	COG0444	Belongs to the ABC transporter superfamily
HMPREF0675_RS06525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0675_RS06530	COG0601	transmembrane transport
HMPREF0675_RS06535	COG0747	negative chemotaxis
HMPREF0675_RS06580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMPREF0675_RS06605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HMPREF0675_RS06615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF0675_RS06655	COG1113	amino acid transport
HMPREF0675_RS06660	COG0180	Tryptophanyl-tRNA synthetase
HMPREF0675_RS06665	COG0613	PHP domain protein
HMPREF0675_RS06670	COG2902	Dehydrogenase
HMPREF0675_RS06690	COG0653	protein targeting
HMPREF0675_RS06695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMPREF0675_RS06705	COG5401	PFAM Sporulation and spore germination
HMPREF0675_RS06710	COG5000	phosphorelay sensor kinase activity
HMPREF0675_RS06710	COG5002	protein histidine kinase activity
HMPREF0675_RS06715	COG0745	RESPONSE REGULATOR receiver
HMPREF0675_RS06720	COG1678	Uncharacterized ACR, COG1678
HMPREF0675_RS06765	COG0165	Argininosuccinate lyase
HMPREF0675_RS06770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HMPREF0675_RS06775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HMPREF0675_RS06785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HMPREF0675_RS06790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMPREF0675_RS06795	COG2177	Part of the ABC transporter FtsEX involved in
HMPREF0675_RS06800	COG2884	Cell division ATP-binding protein ftsE
HMPREF0675_RS06805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF0675_RS06820	COG1674	ftsk spoiiie
HMPREF0675_RS06840	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF0675_RS06865	COG1414	Transcriptional regulator
HMPREF0675_RS06880	COG1266	CAAX protease self-immunity
HMPREF0675_RS06895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF0675_RS06900	COG0473	3-isopropylmalate dehydrogenase activity
HMPREF0675_RS06905	COG0473	3-isopropylmalate dehydrogenase activity
HMPREF0675_RS06915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMPREF0675_RS06930	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF0675_RS06935	COG0107	imidazoleglycerol-phosphate synthase activity
HMPREF0675_RS06940	COG4581	dead DEAH box helicase
HMPREF0675_RS06945	COG0805	protein transport
HMPREF0675_RS06950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPREF0675_RS06970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF0675_RS06975	COG0545	Peptidyl-prolyl cis-trans isomerase
HMPREF0675_RS06995	COG4974	Belongs to the 'phage' integrase family
HMPREF0675_RS07000	COG0494	nUDIX hydrolase
HMPREF0675_RS07005	COG0504	CTP synthase activity
HMPREF0675_RS07020	COG0497	DNA recombination
HMPREF0675_RS07025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMPREF0675_RS07040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMPREF0675_RS07045	COG1122	ATPase activity
HMPREF0675_RS07050	COG1268	BioY protein
HMPREF0675_RS07055	COG0647	UMP catabolic process
HMPREF0675_RS07080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMPREF0675_RS07095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HMPREF0675_RS07100	COG0072	phenylalanine-tRNA ligase activity
HMPREF0675_RS07100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0675_RS07105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMPREF0675_RS07115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMPREF0675_RS07120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HMPREF0675_RS07125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMPREF0675_RS07140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HMPREF0675_RS07145	COG0140	phosphoribosyl-ATP diphosphatase activity
HMPREF0675_RS07150	COG3201	nicotinamide mononucleotide transporter
HMPREF0675_RS07165	COG0667	Aldo Keto reductase
HMPREF0675_RS07170	COG0372	Belongs to the citrate synthase family
HMPREF0675_RS07175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0675_RS07220	COG0792	nuclease activity
HMPREF0675_RS07230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMPREF0675_RS07235	COG0681	Belongs to the peptidase S26 family
HMPREF0675_RS07240	COG0335	large ribosomal subunit rRNA binding
HMPREF0675_RS07250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HMPREF0675_RS07255	COG1053	succinate dehydrogenase
HMPREF0675_RS07265	COG0336	Belongs to the RNA methyltransferase TrmD family
HMPREF0675_RS07270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMPREF0675_RS07275	COG1837	Belongs to the UPF0109 family
HMPREF0675_RS07280	COG0228	four-way junction DNA binding
HMPREF0675_RS07330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HMPREF0675_RS07335	COG0571	ribonuclease III activity
HMPREF0675_RS07340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HMPREF0675_RS07360	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS07365	COG1609	Transcriptional regulator
HMPREF0675_RS07405	COG0444	Belongs to the ABC transporter superfamily
HMPREF0675_RS07415	COG4166	transmembrane transport
HMPREF0675_RS07425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMPREF0675_RS07445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF0675_RS07450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMPREF0675_RS07455	COG0028	Belongs to the TPP enzyme family
HMPREF0675_RS07465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HMPREF0675_RS07470	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF0675_RS07475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMPREF0675_RS07495	COG4175	Glycine betaine
HMPREF0675_RS07495	COG0517	IMP dehydrogenase activity
HMPREF0675_RS07500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMPREF0675_RS07530	COG3732	PTS system glucitol sorbitol-specific
HMPREF0675_RS07545	COG0371	Dehydrogenase
HMPREF0675_RS07550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMPREF0675_RS07565	COG1131	(ABC) transporter
HMPREF0675_RS07570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMPREF0675_RS07575	COG0195	Participates in both transcription termination and antitermination
HMPREF0675_RS07580	COG0779	Required for maturation of 30S ribosomal subunits
HMPREF0675_RS07590	COG0730	response to heat
HMPREF0675_RS07600	COG0442	prolyl-tRNA aminoacylation
HMPREF0675_RS07610	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0675_RS07610	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0675_RS07620	COG1121	(ABC) transporter
HMPREF0675_RS07625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF0675_RS07635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HMPREF0675_RS07650	COG0750	zinc metalloprotease
HMPREF0675_RS07655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HMPREF0675_RS07670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF0675_RS07675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HMPREF0675_RS07680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HMPREF0675_RS07690	COG0575	Belongs to the CDS family
HMPREF0675_RS07695	COG0233	cytoplasmic translational termination
HMPREF0675_RS07700	COG0528	UMP kinase activity
HMPREF0675_RS07705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMPREF0675_RS07710	COG0052	Belongs to the universal ribosomal protein uS2 family
HMPREF0675_RS07715	COG4974	Belongs to the 'phage' integrase family
HMPREF0675_RS07730	COG0242	peptide deformylase activity
HMPREF0675_RS07755	COG1119	ATPase activity
HMPREF0675_RS07765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HMPREF0675_RS07785	COG2226	methyltransferase
HMPREF0675_RS07795	COG0488	(ABC) transporter
HMPREF0675_RS07825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMPREF0675_RS07830	COG0396	ATPase activity
HMPREF0675_RS07845	COG0719	Fe-S assembly protein
HMPREF0675_RS07860	COG1175	transmembrane transport
HMPREF0675_RS07865	COG3833	ABC-type maltose transport systems, permease component
HMPREF0675_RS07875	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HMPREF0675_RS07880	COG1131	(ABC) transporter
HMPREF0675_RS07900	COG0109	protoheme IX farnesyltransferase activity
HMPREF0675_RS07915	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF0675_RS07930	COG0525	valine-tRNA ligase activity
HMPREF0675_RS07935	COG1470	cell adhesion involved in biofilm formation
HMPREF0675_RS07935	COG0366	Alpha amylase catalytic
HMPREF0675_RS07940	COG0793	Belongs to the peptidase S41A family
HMPREF0675_RS07940	COG4946	Tricorn protease homolog
HMPREF0675_RS07945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMPREF0675_RS07950	COG0740	serine-type endopeptidase activity
HMPREF0675_RS07955	COG0740	serine-type endopeptidase activity
HMPREF0675_RS07965	COG0544	peptidyl-prolyl cis-trans isomerase activity
HMPREF0675_RS07990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF0675_RS08010	COG1201	RNA secondary structure unwinding
HMPREF0675_RS08040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMPREF0675_RS08040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF0675_RS08060	COG0698	ribose 5-phosphate isomerase
HMPREF0675_RS08065	COG4552	Acetyltransferase involved in intracellular survival and related
HMPREF0675_RS08070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMPREF0675_RS08090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMPREF0675_RS08125	COG1695	Transcriptional regulator
HMPREF0675_RS08140	COG0629	single-stranded DNA binding
HMPREF0675_RS08170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HMPREF0675_RS08180	COG1113	amino acid transport
HMPREF0675_RS08185	COG0515	serine threonine protein kinase
HMPREF0675_RS08190	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF0675_RS08220	COG0587	DNA-directed DNA polymerase activity
HMPREF0675_RS08240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMPREF0675_RS08255	COG1653	transport
HMPREF0675_RS08350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF0675_RS08360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMPREF0675_RS08365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMPREF0675_RS08370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HMPREF0675_RS08375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HMPREF0675_RS08400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HMPREF0675_RS08430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HMPREF0675_RS08435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPREF0675_RS08445	COG2835	tetraacyldisaccharide 4'-kinase activity
HMPREF0675_RS08480	COG0662	Cupin 2, conserved barrel domain protein
HMPREF0675_RS08480	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HMPREF0675_RS08500	COG1316	TRANSCRIPTIONal
HMPREF0675_RS08525	COG3340	Belongs to the peptidase S51 family
HMPREF0675_RS08540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HMPREF0675_RS08550	COG0424	maF-like protein
HMPREF0675_RS08565	COG4221	oxidoreductase activity
HMPREF0675_RS08570	COG0351	phosphomethylpyrimidine kinase
HMPREF0675_RS08585	COG0598	Magnesium transport protein CorA
HMPREF0675_RS08595	COG4770	biotin carboxylase activity
HMPREF0675_RS08615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0675_RS08620	COG0318	PFAM AMP-dependent synthetase and ligase
HMPREF0675_RS08640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0675_RS08645	COG0328	RNA-DNA hybrid ribonuclease activity
HMPREF0675_RS08655	COG1079	Belongs to the binding-protein-dependent transport system permease family
HMPREF0675_RS08660	COG4603	Belongs to the binding-protein-dependent transport system permease family
HMPREF0675_RS08665	COG3845	ABC transporter
HMPREF0675_RS08670	COG1744	ABC transporter substrate-binding protein PnrA-like
HMPREF0675_RS08685	COG1253	flavin adenine dinucleotide binding
HMPREF0675_RS08705	COG0039	L-malate dehydrogenase activity
HMPREF0675_RS08710	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0675_RS08720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF0675_RS08740	COG0138	bifunctional purine biosynthesis protein purh
HMPREF0675_RS08750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HMPREF0675_RS08755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF0675_RS08755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF0675_RS08765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMPREF0675_RS08765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMPREF0675_RS08780	COG0045	succinate-CoA ligase (ADP-forming) activity
HMPREF0675_RS08795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF0675_RS08800	COG2011	ABC-type metal ion transport system permease component
HMPREF0675_RS08820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HMPREF0675_RS08820	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF0675_RS08830	COG1045	serine acetyltransferase
HMPREF0675_RS08835	COG0287	Prephenate dehydrogenase
HMPREF0675_RS08835	COG1605	Chorismate mutase
HMPREF0675_RS08840	COG0516	GMP reductase activity
HMPREF0675_RS08855	COG1115	amino acid carrier protein
HMPREF0675_RS08865	COG0459	protein refolding
HMPREF0675_RS08870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMPREF0675_RS08895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HMPREF0675_RS08900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0675_RS08915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMPREF0675_RS08920	COG0456	acetyltransferase
HMPREF0675_RS08925	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF0675_RS08925	COG0456	acetyltransferase
HMPREF0675_RS08930	COG0802	atpase or kinase
HMPREF0675_RS08940	COG0513	Belongs to the DEAD box helicase family
HMPREF0675_RS08960	COG1136	(ABC) transporter
HMPREF0675_RS08965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMPREF0675_RS08965	COG0438	transferase activity, transferring glycosyl groups
HMPREF0675_RS08975	COG0736	holo-[acyl-carrier-protein] synthase activity
HMPREF0675_RS08980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF0675_RS08995	COG1072	(Pantothenic acid kinase))
HMPREF0675_RS09005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0675_RS09010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HMPREF0675_RS09015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF0675_RS09040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HMPREF0675_RS09045	COG0101	tRNA pseudouridine synthase activity
HMPREF0675_RS09060	COG3845	ABC transporter
HMPREF0675_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0675_RS09095	COG2271	Major facilitator Superfamily
HMPREF0675_RS09105	COG0438	transferase activity, transferring glycosyl groups
HMPREF0675_RS09110	COG0203	ribosomal protein L17
HMPREF0675_RS09115	COG0202	RNA polymerase activity
HMPREF0675_RS09120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMPREF0675_RS09125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF0675_RS09130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMPREF0675_RS09135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMPREF0675_RS09140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF0675_RS09150	COG0563	adenylate kinase activity
HMPREF0675_RS09170	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF0675_RS09185	COG0200	Binds to the 23S rRNA
HMPREF0675_RS09190	COG1841	ribosomal large subunit assembly
HMPREF0675_RS09195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF0675_RS09200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMPREF0675_RS09205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMPREF0675_RS09210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMPREF0675_RS09215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMPREF0675_RS09220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMPREF0675_RS09225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMPREF0675_RS09230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMPREF0675_RS09235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF0675_RS09240	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF0675_RS09245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMPREF0675_RS09250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMPREF0675_RS09255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMPREF0675_RS09260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF0675_RS09265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMPREF0675_RS09270	COG0089	rRNA binding
HMPREF0675_RS09275	COG0088	Forms part of the polypeptide exit tunnel
HMPREF0675_RS09280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMPREF0675_RS09285	COG0051	transcription antitermination factor activity, RNA binding
HMPREF0675_RS09310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF0675_RS09315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF0675_RS09320	COG0737	Belongs to the 5'-nucleotidase family
HMPREF0675_RS09330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMPREF0675_RS09350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF0675_RS09355	COG0049	tRNA binding
HMPREF0675_RS09360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMPREF0675_RS09380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMPREF0675_RS09385	COG0085	RNA polymerase activity
HMPREF0675_RS09390	COG0222	ribosome binding
HMPREF0675_RS09395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMPREF0675_RS09400	COG0081	regulation of translation
HMPREF0675_RS09405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMPREF0675_RS09410	COG0250	Participates in transcription elongation, termination and antitermination
HMPREF0675_RS09415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF0675_RS09425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF0675_RS09430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HMPREF0675_RS09440	COG2030	dehydratase
HMPREF0675_RS09445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF0675_RS09465	COG0708	Exodeoxyribonuclease III
HMPREF0675_RS09470	COG1024	Enoyl-CoA hydratase
HMPREF0675_RS09480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF0675_RS09485	COG0649	NAD binding
HMPREF0675_RS09490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF0675_RS09500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPREF0675_RS09500	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPREF0675_RS09505	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPREF0675_RS09535	COG3590	peptidase
HMPREF0675_RS09545	COG1126	abc transporter atp-binding protein
HMPREF0675_RS09560	COG1131	(ABC) transporter
HMPREF0675_RS09580	COG2301	Belongs to the HpcH HpaI aldolase family
HMPREF0675_RS09590	COG0142	geranyltranstransferase activity
HMPREF0675_RS09595	COG1007	ATP synthesis coupled electron transport
HMPREF0675_RS09610	COG0713	ATP synthesis coupled electron transport
HMPREF0675_RS09620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF0675_RS09625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HMPREF0675_RS09630	COG1034	ATP synthesis coupled electron transport
HMPREF0675_RS09635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HMPREF0675_RS09645	COG0649	NAD binding
HMPREF0675_RS09650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF0675_RS09655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF0675_RS09665	COG0644	oxidoreductase
HMPREF0675_RS09690	COG2226	methyltransferase
HMPREF0675_RS09705	COG1132	(ABC) transporter
HMPREF0675_RS09715	COG1136	(ABC) transporter
HMPREF0675_RS09735	COG2376	Dihydroxyacetone kinase
HMPREF0675_RS09740	COG1461	Dihydroxyacetone kinase
HMPREF0675_RS09745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF0675_RS09745	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HMPREF0675_RS09745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0675_RS09755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPREF0675_RS09765	COG0039	L-malate dehydrogenase activity
HMPREF0675_RS09795	COG1175	transmembrane transport
HMPREF0675_RS09800	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS09835	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS09840	COG1175	transmembrane transport
HMPREF0675_RS09860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HMPREF0675_RS09875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0675_RS09900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF0675_RS09920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0675_RS09950	COG0047	phosphoribosylformylglycinamidine synthase activity
HMPREF0675_RS09955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HMPREF0675_RS09975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF0675_RS09980	COG0151	Belongs to the GarS family
HMPREF0675_RS09985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMPREF0675_RS09995	COG2188	Transcriptional regulator
HMPREF0675_RS10000	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HMPREF0675_RS10005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF0675_RS10025	COG1217	gtp-binding protein TYPA
HMPREF0675_RS10055	COG0840	transmembrane signaling receptor activity
HMPREF0675_RS10065	COG0191	fructose-bisphosphate aldolase activity
HMPREF0675_RS10080	COG0586	Pfam SNARE associated Golgi protein
HMPREF0675_RS10100	COG3012	SEC-C Motif Domain Protein
HMPREF0675_RS10105	COG0477	Major facilitator Superfamily
HMPREF0675_RS10110	COG0542	response to heat
HMPREF0675_RS10125	COG3588	fructose-bisphosphate aldolase
HMPREF0675_RS10140	COG4585	Histidine kinase
HMPREF0675_RS10145	COG2197	response regulator
HMPREF0675_RS10150	COG4591	ABC-type transport system involved in lipoprotein release permease component
HMPREF0675_RS10150	COG1136	(ABC) transporter
HMPREF0675_RS10155	COG0577	efflux transmembrane transporter activity
HMPREF0675_RS10155	COG1136	(ABC) transporter
HMPREF0675_RS10160	COG1051	belongs to the nudix hydrolase family
HMPREF0675_RS10165	COG1113	amino acid transport
HMPREF0675_RS10170	COG0569	domain protein
HMPREF0675_RS10170	COG2985	domain, Protein
HMPREF0675_RS10175	COG1063	alcohol dehydrogenase
HMPREF0675_RS10185	COG0789	Transcriptional regulator
HMPREF0675_RS10190	COG0484	heat shock protein binding
HMPREF0675_RS10195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMPREF0675_RS10215	COG0745	RESPONSE REGULATOR receiver
HMPREF0675_RS10225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF0675_RS10240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF0675_RS10240	COG0574	Belongs to the PEP-utilizing enzyme family
HMPREF0675_RS10245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HMPREF0675_RS10255	COG3830	Belongs to the UPF0237 family
HMPREF0675_RS10255	COG0560	Phosphoserine phosphatase
HMPREF0675_RS10260	COG0676	glucose-6-phosphate 1-epimerase activity
HMPREF0675_RS10325	COG0662	Cupin 2, conserved barrel domain protein
HMPREF0675_RS10340	COG2375	cellular response to nickel ion
HMPREF0675_RS10340	COG1132	(ABC) transporter
HMPREF0675_RS10370	COG1131	(ABC) transporter
HMPREF0675_RS10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF0675_RS10385	COG0022	dehydrogenase e1 component
HMPREF0675_RS10395	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HMPREF0675_RS10400	COG0535	radical SAM domain protein
HMPREF0675_RS10420	COG1132	(ABC) transporter
HMPREF0675_RS10435	COG2378	regulation of single-species biofilm formation
HMPREF0675_RS10475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF0675_RS10490	COG2205	protein histidine kinase activity
HMPREF0675_RS10505	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HMPREF0675_RS10520	COG1902	pentaerythritol trinitrate reductase activity
HMPREF0675_RS10530	COG0477	Major facilitator Superfamily
HMPREF0675_RS10535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF0675_RS10535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0675_RS10540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0675_RS10570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMPREF0675_RS10575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMPREF0675_RS10585	COG0018	arginyl-trna synthetase
HMPREF0675_RS10590	COG0656	L-ascorbic acid biosynthetic process
HMPREF0675_RS10600	COG0166	Belongs to the GPI family
HMPREF0675_RS10615	COG0783	Belongs to the Dps family
HMPREF0675_RS10620	COG4581	dead DEAH box helicase
HMPREF0675_RS10625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF0675_RS10635	COG1881	PFAM PEBP family protein
HMPREF0675_RS10680	COG0701	Predicted permease
HMPREF0675_RS10700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0675_RS10705	COG1408	metallophosphoesterase
HMPREF0675_RS10715	COG0693	protein deglycase activity
HMPREF0675_RS10720	COG0747	negative chemotaxis
HMPREF0675_RS10725	COG0601	transmembrane transport
HMPREF0675_RS10730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0675_RS10740	COG4608	Belongs to the ABC transporter superfamily
HMPREF0675_RS10745	COG0254	rRNA binding
HMPREF0675_RS10750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF0675_RS10755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF0675_RS10760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMPREF0675_RS10775	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF0675_RS10780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMPREF0675_RS10785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0675_RS10795	COG1228	amidohydrolase
HMPREF0675_RS10800	COG2986	histidine ammonia-lyase
HMPREF0675_RS10805	COG1518	maintenance of DNA repeat elements
HMPREF0675_RS10815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMPREF0675_RS10830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMPREF0675_RS10850	COG3263	regulation of cellular component size
HMPREF0675_RS10880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMPREF0675_RS10900	COG3158	transport of potassium into the cell
HMPREF0675_RS10905	COG0505	Belongs to the CarA family
HMPREF0675_RS10930	COG1609	Transcriptional regulator
HMPREF0675_RS10935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF0675_RS10975	COG0137	argininosuccinate synthase activity
HMPREF0675_RS11000	COG0561	phosphatase activity
HMPREF0675_RS11040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HMPREF0675_RS11045	COG0644	oxidoreductase
HMPREF0675_RS11085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMPREF0675_RS11100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HMPREF0675_RS11115	COG1968	undecaprenyl-diphosphatase activity
HMPREF0675_RS11120	COG1528	Iron-storage protein
HMPREF0675_RS11135	COG0359	binds to the 23S rRNA
HMPREF0675_RS11140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF0675_RS11150	COG0360	Binds together with S18 to 16S ribosomal RNA
HMPREF0675_RS11160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS11160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0675_RS11160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS11165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0675_RS11165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS11165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0675_RS11175	COG1022	Amp-dependent synthetase and ligase
HMPREF0675_RS11180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HMPREF0675_RS11200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMPREF0675_RS11210	COG2608	mercury ion transmembrane transporter activity
HMPREF0675_RS11215	COG1937	Protein conserved in bacteria
HMPREF0675_RS11220	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF0675_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0675_RS11225	COG0604	alcohol dehydrogenase
HMPREF0675_RS11225	COG3321	synthase
HMPREF0675_RS11235	COG2094	Belongs to the DNA glycosylase MPG family
HMPREF0675_RS11250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMPREF0675_RS11255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF0675_RS11270	COG1113	amino acid transport
HMPREF0675_RS11290	COG0534	Mate efflux family protein
HMPREF0675_RS11305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF0675_RS11330	COG0205	6-phosphofructokinase activity
HMPREF0675_RS11335	COG0686	Belongs to the AlaDH PNT family
HMPREF0675_RS11340	COG1113	amino acid transport
HMPREF0675_RS11350	COG1376	ErfK ybiS ycfS ynhG family protein
HMPREF0675_RS11355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMPREF0675_RS11365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HMPREF0675_RS11370	COG0686	Belongs to the AlaDH PNT family
HMPREF0675_RS11400	COG5012	cobalamin binding
HMPREF0675_RS11410	COG3457	Alanine racemase
HMPREF0675_RS11415	COG1113	amino acid transport
HMPREF0675_RS11420	COG1113	amino acid transport
HMPREF0675_RS11425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF0675_RS11430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0675_RS11435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF0675_RS11455	COG0114	fumarate hydratase activity
HMPREF0675_RS11460	COG0395	ABC-type sugar transport system, permease component
HMPREF0675_RS11465	COG1175	transmembrane transport
HMPREF0675_RS11485	COG0668	transmembrane transport
HMPREF0675_RS11490	COG1929	Belongs to the glycerate kinase type-1 family
HMPREF0675_RS11500	COG0617	tRNA 3'-terminal CCA addition
HMPREF0675_RS11510	COG0515	serine threonine protein kinase
HMPREF0675_RS11515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMPREF0675_RS11520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF0675_RS11530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF0675_RS11540	COG0492	ferredoxin-NADP+ reductase activity
HMPREF0675_RS11555	COG0657	acetylesterase activity
HMPREF0675_RS11565	COG3118	belongs to the thioredoxin family
HMPREF0675_RS11595	COG0371	Dehydrogenase
HMPREF0675_RS11600	COG1069	ribulokinase activity
HMPREF0675_RS11620	COG0698	ribose 5-phosphate isomerase
HMPREF0675_RS11630	COG1349	DNA-binding transcription factor activity
HMPREF0675_RS11635	COG1312	Catalyzes the dehydration of D-mannonate
HMPREF0675_RS11640	COG0246	Mannitol dehydrogenase
HMPREF0675_RS11645	COG1904	glucuronate isomerase
HMPREF0675_RS11650	COG1609	Transcriptional regulator
HMPREF0675_RS11655	COG2211	Major facilitator Superfamily
HMPREF0675_RS11665	COG3250	beta-galactosidase activity
HMPREF0675_RS11680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF0675_RS11685	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF0675_RS11695	COG2814	Major facilitator Superfamily
HMPREF0675_RS11700	COG1475	DNA binding
HMPREF0675_RS11715	COG0357	Ribosomal RNA small subunit methyltransferase G
HMPREF0675_RS11745	COG0706	membrane insertase activity
HMPREF0675_RS11755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HMPREF0675_RS11810	COG3775	system Galactitol-specific IIC component
HMPREF0675_RS11815	COG3775	system Galactitol-specific IIC component
HMPREF0675_RS11860	COG1120	ATPase activity
HMPREF0675_RS11895	COG0438	transferase activity, transferring glycosyl groups
HMPREF0675_RS12055	COG1854	S-ribosylhomocysteine lyase activity
HMPREF0675_RS12110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMPREF0675_RS12275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HMPREF0675_RS12335	COG0667	Aldo Keto reductase
HMPREF0675_RS12505	COG0473	3-isopropylmalate dehydrogenase activity
HMPREF0675_RS13010	COG1609	Transcriptional regulator
HMPREF0675_RS13075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HMPREF0675_RS13080	COG0594	ribonuclease P activity
HMPREF0675_RS13145	COG1136	(ABC) transporter
HMPREF0675_RS13200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity