locus-tag	class	description
CASZ2_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
CASZ2_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
CASZ2_RS00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
CASZ2_RS00030	ENOG4105BZ1	(ABC) transporter
CASZ2_RS00045	ENOG4105EIP	mannose-6-phosphate isomerase
CASZ2_RS00050	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CASZ2_RS00055	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CASZ2_RS00060	ENOG4108ZED	Transmembrane domain of unknown function (DUF3566)
CASZ2_RS00065	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
CASZ2_RS00070	ENOG4105ETE	Transcriptional regulator (LacI family
CASZ2_RS00075	ENOG4105C2J	ABC transporter
CASZ2_RS00080	ENOG4105CNN	ABC, transporter
CASZ2_RS00085	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
CASZ2_RS00090	ENOG4108RVA	ribokinase
CASZ2_RS00095	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
CASZ2_RS00115	ENOG4105DT3	PTS system, galactitol-specific IIc component
CASZ2_RS00120	ENOG4105K18	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
CASZ2_RS00125	ENOG4105CPQ	Dehydrogenase
CASZ2_RS00175	ENOG4105CIH	Imidazole acetol-phosphate transaminase
CASZ2_RS00245	ENOG4105CKU	formyltetrahydrofolate synthetase
CASZ2_RS00265	ENOG4105D60	lipoprotein releasing system transmembrane protein
CASZ2_RS00270	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CASZ2_RS00275	ENOG4105WH1	Two component transcriptional regulator luxr family
CASZ2_RS00285	ENOG4105DRS	transport system, permease
CASZ2_RS00300	ENOG4107EDW	L-fucose operon activator
CASZ2_RS00330	ENOG4105E2D	ec 3.2.1.52
CASZ2_RS00340	ENOG4105BZU	Histidine kinase
CASZ2_RS00350	ENOG4105YA8	Transcriptional regulator
CASZ2_RS00355	ENOG4105EYF	MMPL domain protein
CASZ2_RS00375	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CASZ2_RS00390	ENOG4105EHG	Permease protein
CASZ2_RS00395	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
CASZ2_RS00405	ENOG4105CMQ	Chloride channel
CASZ2_RS00425	ENOG4105CT8	Phosphorylase
CASZ2_RS00440	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
CASZ2_RS00470	ENOG4105CTQ	phosphohexokinase
CASZ2_RS00490	ENOG4108IJ0	Aspartate ammonia-lyase
CASZ2_RS00495	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
CASZ2_RS00505	ENOG4105CH6	catalase
CASZ2_RS00510	ENOG4105BZ1	(ABC) transporter
CASZ2_RS00515	ENOG4105BZ1	(ABC) transporter
CASZ2_RS00520	ENOG4105EET	magnesium chelatase
CASZ2_RS00535	ENOG4105C4X	radical SAM domain protein
CASZ2_RS00540	ENOG4105E0A	ABC, transporter
CASZ2_RS00545	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
CASZ2_RS00555	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
CASZ2_RS00570	ENOG4105DWF	phosphomethylpyrimidine kinase
CASZ2_RS00580	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
CASZ2_RS00600	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
CASZ2_RS00610	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
CASZ2_RS00655	ENOG4105BZ4	penicillin-binding protein
CASZ2_RS00680	ENOG4107EF8	Glycosyl transferase (Group 1
CASZ2_RS00715	ENOG4105DUX	Transporter
CASZ2_RS00725	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
CASZ2_RS00735	ENOG4105DM4	PTS System
CASZ2_RS00740	ENOG4105DE4	1-phosphofructokinase
CASZ2_RS00750	ENOG4105E98	transcriptional regulator DeoR family
CASZ2_RS00755	ENOG4107QQG	Dehydrogenase
CASZ2_RS00765	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
CASZ2_RS00770	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
CASZ2_RS00775	ENOG4107QPH	glycogen) synthase
CASZ2_RS00805	ENOG4105CQ7	ATP-dependent helicase
CASZ2_RS00810	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
CASZ2_RS00815	ENOG4108JJB	ABC transporter
CASZ2_RS00835	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
CASZ2_RS00860	ENOG4105DAA	L-lactate
CASZ2_RS00865	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
CASZ2_RS00870	ENOG4107QR9	Iron-sulfur cluster binding protein
CASZ2_RS00875	ENOG41080R8	Conserved Protein
CASZ2_RS00880	ENOG4108JJB	ABC transporter
CASZ2_RS00895	ENOG4108JJ8	(ABC) transporter
CASZ2_RS00900	ENOG4108JJ9	ABC, transporter
CASZ2_RS00905	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
CASZ2_RS00910	ENOG4105C4M	(Ubiquinol oxidase) subunit I
CASZ2_RS00945	ENOG4105CRK	lysyL-tRNA synthetase
CASZ2_RS00950	ENOG4105ZJT	Cell division protein CrgA
CASZ2_RS00960	ENOG4105D9P	serine threonine protein kinase
CASZ2_RS00965	ENOG4105CJN	penicillin-binding protein
CASZ2_RS00980	ENOG4105HZM	Fha domain containing protein
CASZ2_RS01090	ENOG41087ID	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
CASZ2_RS01095	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
CASZ2_RS01105	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CASZ2_RS01120	ENOG4105DQF	Hydrolase
CASZ2_RS01125	ENOG4105DQF	Hydrolase
CASZ2_RS01130	ENOG4108IY8	ABC, transporter
CASZ2_RS01160	ENOG4105C44	Serine transporter
CASZ2_RS01170	ENOG4105D9R	oxidoreductase
CASZ2_RS01205	ENOG4105P8F	nudix hydrolase
CASZ2_RS01215	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
CASZ2_RS01270	ENOG4108I5C	dEAD DEAH box helicase
CASZ2_RS01275	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
CASZ2_RS01285	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
CASZ2_RS01295	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
CASZ2_RS01300	ENOG4105C6E	dna polymerase iii
CASZ2_RS01310	ENOG4105MA4	psp1 domain protein
CASZ2_RS01335	ENOG4105CVN	desaturase
CASZ2_RS01350	ENOG4105I82	acetyl xylan esterase
CASZ2_RS01360	ENOG4105F0N	pyrophosphate phospho-hydrolase
CASZ2_RS01370	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
CASZ2_RS01385	ENOG4105EUJ	GTP cyclohydrolase i
CASZ2_RS01425	ENOG4105EEI	dihydropteroate synthase
CASZ2_RS01430	ENOG4105KRF	dihydroneopterin aldolase
CASZ2_RS01450	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS01480	ENOG4105E7W	lamb ycsf family protein
CASZ2_RS01485	ENOG4105P4J	Allophanate hydrolase, subunit 1
CASZ2_RS01490	ENOG4107R7A	Allophanate hydrolase subunit 2
CASZ2_RS01500	ENOG4105ECP	epimerase
CASZ2_RS01515	ENOG4105WH1	Two component transcriptional regulator luxr family
CASZ2_RS01520	ENOG4105BZU	Histidine kinase
CASZ2_RS01530	ENOG4105CID	antiterminator
CASZ2_RS01540	ENOG4105CI1	PTS System
CASZ2_RS01555	ENOG4105CEN	a g-specific adenine glycosylase
CASZ2_RS01560	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
CASZ2_RS01565	ENOG4105D52	delta-aminolevulinic acid dehydratase
CASZ2_RS01575	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
CASZ2_RS01585	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
CASZ2_RS01590	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
CASZ2_RS01595	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
CASZ2_RS01615	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
CASZ2_RS01630	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
CASZ2_RS01650	ENOG4105II7	pyrroline-5-carboxylate reductase
CASZ2_RS01670	ENOG4108RH7	phosphoglycerate mutase
CASZ2_RS01675	ENOG4107ZT5	Thiol disulfide interchange protein
CASZ2_RS01680	ENOG4107QIV	Cytochrome c biogenesis protein
CASZ2_RS01685	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
CASZ2_RS01690	ENOG4105CRE	cytochrome C
CASZ2_RS01700	ENOG4105EMU	Dehydrogenase
CASZ2_RS01730	ENOG4105E0A	ABC, transporter
CASZ2_RS01735	ENOG4105EHG	Permease protein
CASZ2_RS01745	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
CASZ2_RS01760	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
CASZ2_RS01770	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
CASZ2_RS01775	ENOG4107NHD	transcriptional regulator
CASZ2_RS01785	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
CASZ2_RS01790	ENOG4108SVG	May play a role in the intracellular transport of hydrophobic ligands
CASZ2_RS01810	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
CASZ2_RS01815	ENOG410849S	phosphocarrier protein (HPr)
CASZ2_RS01820	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
CASZ2_RS01825	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
CASZ2_RS01840	ENOG4108VJ1	Transcriptional regulator (CarD family
CASZ2_RS01875	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CASZ2_RS01890	ENOG4105HDK	L-asparaginase
CASZ2_RS01900	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
CASZ2_RS01905	ENOG4105D7K	pfkb domain protein
CASZ2_RS01910	ENOG4108UHU	Aldolase
CASZ2_RS01925	ENOG4106AM8	polysaccharide lyase family 8
CASZ2_RS01955	ENOG4105C8N	cysteinyl-tRNA synthetase
CASZ2_RS01970	ENOG4105VBF	alkaline shock protein
CASZ2_RS02015	ENOG4105EJQ	L-serine dehydratase
CASZ2_RS02025	ENOG4105EP9	oxidoreductase
CASZ2_RS02030	ENOG4107FKK	extracellular solute-binding protein family 1
CASZ2_RS02040	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
CASZ2_RS02045	ENOG4105CPQ	Dehydrogenase
CASZ2_RS02050	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
CASZ2_RS02060	ENOG4105E90	ABC transporter
CASZ2_RS02085	ENOG4108UVJ	appr-1-p processing domain protein
CASZ2_RS02090	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
CASZ2_RS02095	ENOG4108M15	ABC transporter
CASZ2_RS02105	ENOG4108ZGX	Histidine kinase
CASZ2_RS02115	ENOG4105CVJ	phosphoglycerate mutase
CASZ2_RS02120	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
CASZ2_RS02125	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
CASZ2_RS02135	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
CASZ2_RS02140	ENOG4105E4R	Precorrin-3B C17-methyltransferase
CASZ2_RS02145	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
CASZ2_RS02160	ENOG4105DQ5	transport system permease protein
CASZ2_RS02165	ENOG4105E0A	ABC, transporter
CASZ2_RS02185	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
CASZ2_RS02195	ENOG4108V4M	Cobalt abc transporter
CASZ2_RS02200	ENOG4108JJB	ABC transporter
CASZ2_RS02210	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
CASZ2_RS02220	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
CASZ2_RS02225	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
CASZ2_RS02230	ENOG4105QUC	reductase
CASZ2_RS02235	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
CASZ2_RS02280	ENOG4105DM4	PTS System
CASZ2_RS02305	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
CASZ2_RS02310	ENOG4105EIP	mannose-6-phosphate isomerase
CASZ2_RS02325	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
CASZ2_RS02330	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
CASZ2_RS02340	ENOG4105D7K	pfkb domain protein
CASZ2_RS02350	ENOG4105DH8	myo-inositol catabolism
CASZ2_RS02355	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
CASZ2_RS02365	ENOG4105C26	Dehydrogenase
CASZ2_RS02370	ENOG4105ETE	Transcriptional regulator (LacI family
CASZ2_RS02380	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
CASZ2_RS02385	ENOG4105F0H	myo-inositol catabolism protein
CASZ2_RS02390	ENOG4105CK5	oxidoreductase
CASZ2_RS02395	ENOG4107QNK	)-transporter
CASZ2_RS02410	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
CASZ2_RS02425	ENOG4106N3A	copper homeostasis protein cutc
CASZ2_RS02435	ENOG4105CFI	type iii restriction protein res subunit
CASZ2_RS02460	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
CASZ2_RS02465	ENOG4105VEQ	Cold shock protein
CASZ2_RS02480	ENOG4105C7N	Xanthine uracil vitamin C permease
CASZ2_RS02495	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
CASZ2_RS02500	ENOG4105CE4	GlcNAc 6-P deacetylase
CASZ2_RS02520	ENOG4107QNK	)-transporter
CASZ2_RS02540	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
CASZ2_RS02555	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
CASZ2_RS02560	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
CASZ2_RS02565	ENOG4108YYQ	gCN5-related N-acetyltransferase
CASZ2_RS02585	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CASZ2_RS02605	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CASZ2_RS02640	ENOG4108IUE	nitrate reductase beta subunit
CASZ2_RS02660	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
CASZ2_RS02675	ENOG4105QAX	Iron-sulfur
CASZ2_RS02680	ENOG4107QY8	reductase
CASZ2_RS02690	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
CASZ2_RS02700	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
CASZ2_RS02705	ENOG4105D7N	magnesium and cobalt transport protein CorA
CASZ2_RS02715	ENOG4105C2W	permease
CASZ2_RS02730	ENOG4105F8V	Hydrolase, tatD family
CASZ2_RS02735	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
CASZ2_RS02740	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
CASZ2_RS02745	ENOG41082F9	transcriptional regulator
CASZ2_RS02760	ENOG4107U1N	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
CASZ2_RS02765	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
CASZ2_RS02785	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
CASZ2_RS02790	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
CASZ2_RS02800	ENOG4105C5I	Dehydrogenase
CASZ2_RS02840	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
CASZ2_RS02910	ENOG4105EPD	Oligopeptide transporter, Opt family
CASZ2_RS02915	ENOG4105CPC	Aldo Keto reductase
CASZ2_RS02920	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
CASZ2_RS02925	ENOG4105C8J	)-transporter
CASZ2_RS02935	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
CASZ2_RS02955	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
CASZ2_RS02970	ENOG4105C7Z	Conserved Protein
CASZ2_RS02975	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
CASZ2_RS02985	ENOG4108IAB	Phoh family
CASZ2_RS02995	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
CASZ2_RS03000	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
CASZ2_RS03010	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
CASZ2_RS03020	ENOG4105DFM	M18 family aminopeptidase
CASZ2_RS03025	ENOG4105C3G	gtp-binding protein
CASZ2_RS03045	ENOG4105K56	Transcriptional regulator
CASZ2_RS03050	ENOG4108ZHJ	Organic hydroperoxide resistance protein
CASZ2_RS03060	ENOG4105D5Q	Arginine ornithine antiporter
CASZ2_RS03065	ENOG4105CEU	Arginine dihydrolase
CASZ2_RS03070	ENOG4105DBV	ornithine carbamoyltransferase
CASZ2_RS03075	ENOG4105C5B	carbamate kinase
CASZ2_RS03090	ENOG4105VUC	UPF0237 protein
CASZ2_RS03095	ENOG4105CPC	Aldo Keto reductase
CASZ2_RS03100	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
CASZ2_RS03105	ENOG4108IQI	permease
CASZ2_RS03110	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
CASZ2_RS03130	ENOG4105CMN	Methylmalonyl-coA mutase
CASZ2_RS03135	ENOG4105D5P	Methylmalonyl-coA mutase
CASZ2_RS03145	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
CASZ2_RS03150	ENOG410848D	S4 domain protein YaaA
CASZ2_RS03155	ENOG4105CDA	abc transporter atp-binding protein
CASZ2_RS03170	ENOG41060NJ	transcriptional regulator
CASZ2_RS03185	ENOG4105F38	ABC transporter, permease
CASZ2_RS03190	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
CASZ2_RS03200	ENOG4105EHF	Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity)
CASZ2_RS03225	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CASZ2_RS03240	ENOG4105CC5	ABC transporter
CASZ2_RS03245	ENOG4105DIK	(ABC) transporter
CASZ2_RS03250	ENOG4105DSE	periplasmic solute binding protein
CASZ2_RS03265	ENOG4105C26	Dehydrogenase
CASZ2_RS03270	ENOG4105CPQ	Dehydrogenase
CASZ2_RS03275	ENOG4105CMT	Dihydroxyacetone kinase
CASZ2_RS03280	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
CASZ2_RS03290	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
CASZ2_RS03295	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
CASZ2_RS03300	ENOG4108Z4U	Ferredoxin
CASZ2_RS03315	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
CASZ2_RS03335	ENOG4105CSH	Transporter
CASZ2_RS03360	ENOG4107QPH	glycogen) synthase
CASZ2_RS03365	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
CASZ2_RS03375	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
CASZ2_RS03380	ENOG410630M	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
CASZ2_RS03415	ENOG4107T6F	Xaa-Pro aminopeptidase
CASZ2_RS03450	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
CASZ2_RS03455	ENOG4105E0A	ABC, transporter
CASZ2_RS03495	ENOG4105C5F	glutamine synthetase
CASZ2_RS03505	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
CASZ2_RS03530	ENOG4105C5F	glutamine synthetase
CASZ2_RS03540	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
CASZ2_RS03560	ENOG4105CI1	PTS System
CASZ2_RS03575	ENOG4105R3P	Inner membrane protein yagU
CASZ2_RS03580	ENOG4108VJY	integral membrane protein
CASZ2_RS03585	ENOG4105C5H	ABC transporter
CASZ2_RS03605	ENOG4105JHE	Major Facilitator Superfamily
CASZ2_RS03625	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
CASZ2_RS03640	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
CASZ2_RS03650	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
CASZ2_RS03685	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
CASZ2_RS03690	ENOG4105BZ9	Cytochrome C oxidase, subunit I
CASZ2_RS03695	ENOG4105MCD	Part of cytochrome c oxidase, its function is
CASZ2_RS03730	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
CASZ2_RS03735	ENOG4107EUI	c reductase, iron-sulfur
CASZ2_RS03740	ENOG4107UDY	cytochrome C
CASZ2_RS03745	ENOG4105CCU	oxidase (Subunit III)
CASZ2_RS03755	ENOG4107QYG	anthranilate phosphoribosyltransferase
CASZ2_RS03770	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
CASZ2_RS03775	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
CASZ2_RS03800	ENOG4105DKQ	ROK family
CASZ2_RS03820	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
CASZ2_RS03825	ENOG4107YM4	Beta-lactamase domain-containing protein
CASZ2_RS03860	ENOG4105C4R	Atp-dependent dna helicase
CASZ2_RS03895	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CASZ2_RS03900	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
CASZ2_RS03905	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
CASZ2_RS03925	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CASZ2_RS03930	ENOG4108V6E	Cell division protein mraZ
CASZ2_RS03935	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
CASZ2_RS03945	ENOG4105CJN	penicillin-binding protein
CASZ2_RS03950	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
CASZ2_RS03960	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
CASZ2_RS03965	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
CASZ2_RS03975	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
CASZ2_RS03980	ENOG4105DFU	Cell wall formation (By similarity)
CASZ2_RS03990	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
CASZ2_RS03995	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
CASZ2_RS04000	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
CASZ2_RS04030	ENOG4105CA9	Pyruvate kinase
CASZ2_RS04035	ENOG41085J0	Protein CrcB homolog
CASZ2_RS04040	ENOG4108680	CrcB-like protein
CASZ2_RS04070	ENOG4105CQB	FAD linked oxidase domain protein
CASZ2_RS04080	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
CASZ2_RS04095	ENOG4105EHG	Permease protein
CASZ2_RS04100	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
CASZ2_RS04105	ENOG4108JJ9	ABC, transporter
CASZ2_RS04110	ENOG4105BZ1	(ABC) transporter
CASZ2_RS04115	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
CASZ2_RS04125	ENOG4105EET	magnesium chelatase
CASZ2_RS04140	ENOG4105CTK	cobaltochelatase, cobn subunit
CASZ2_RS04145	ENOG4105E0A	ABC, transporter
CASZ2_RS04150	ENOG4108U1V	ABC transporter, permease
CASZ2_RS04165	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CASZ2_RS04170	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CASZ2_RS04195	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
CASZ2_RS04205	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
CASZ2_RS04235	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
CASZ2_RS04240	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
CASZ2_RS04245	ENOG4105CHW	UPF0052 protein
CASZ2_RS04250	ENOG4105CIE	May be required for sporulation (By similarity)
CASZ2_RS04255	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
CASZ2_RS04260	ENOG4105BZA	Phosphoglycerate kinase
CASZ2_RS04265	ENOG4105CP7	Triose-phosphate isomerase
CASZ2_RS04280	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
CASZ2_RS04290	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
CASZ2_RS04305	ENOG4105C03	ribonuclease
CASZ2_RS04310	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
CASZ2_RS04315	ENOG4105K46	50S ribosomal protein l27
CASZ2_RS04325	ENOG41060BG	Tetr family transcriptional regulator
CASZ2_RS04335	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CASZ2_RS04340	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
CASZ2_RS04345	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
CASZ2_RS04350	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
CASZ2_RS04360	ENOG4105CVJ	phosphoglycerate mutase
CASZ2_RS04405	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
CASZ2_RS04450	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CASZ2_RS04455	ENOG4105BZU	Histidine kinase
CASZ2_RS04460	ENOG4105WH1	Two component transcriptional regulator luxr family
CASZ2_RS04475	ENOG4105EQN	UPF0261 protein
CASZ2_RS04510	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
CASZ2_RS04525	ENOG41080QX	K07048 phosphotriesterase-related protein
CASZ2_RS04530	ENOG4105H6Q	decarboxylase
CASZ2_RS04550	ENOG4105C2C	drug resistance transporter, Bcr CflA
CASZ2_RS04560	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
CASZ2_RS04565	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
CASZ2_RS04570	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
CASZ2_RS04575	ENOG4105C6K	Malic enzyme
CASZ2_RS04600	ENOG4105C8T	Leucyl-tRNA synthetase
CASZ2_RS04605	ENOG4105KQC	Competence protein
CASZ2_RS04625	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
CASZ2_RS04630	ENOG4107QW3	Sucrose phosphorylase
CASZ2_RS04635	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
CASZ2_RS04640	ENOG4107TCW	O-succinylbenzoate synthase
CASZ2_RS04645	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
CASZ2_RS04650	ENOG4105E4F	Isochorismate synthase
CASZ2_RS04680	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
CASZ2_RS04690	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
CASZ2_RS04715	ENOG4105ECY	inositol monophosphatase
CASZ2_RS04720	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
CASZ2_RS04725	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
CASZ2_RS04730	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
CASZ2_RS04740	ENOG4105CPQ	Dehydrogenase
CASZ2_RS04745	ENOG4105CTS	PTS system mannitol-specific
CASZ2_RS04755	ENOG4105C9U	ATP-dependent DNA helicase RecQ
CASZ2_RS04760	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
CASZ2_RS04770	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
CASZ2_RS04775	ENOG4108ZGX	Histidine kinase
CASZ2_RS04780	ENOG4105WH1	Two component transcriptional regulator luxr family
CASZ2_RS04785	ENOG4108IUX	(ABC) transporter
CASZ2_RS04820	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
CASZ2_RS04830	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
CASZ2_RS04835	ENOG4105CPN	adenine deaminase
CASZ2_RS04840	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
CASZ2_RS04845	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
CASZ2_RS04855	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
CASZ2_RS04870	ENOG4108VB1	regulatoR
CASZ2_RS04880	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
CASZ2_RS04900	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
CASZ2_RS04920	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
CASZ2_RS04925	ENOG4105I8R	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
CASZ2_RS04940	ENOG4105DEN	Luciferase family
CASZ2_RS04945	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
CASZ2_RS04965	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
CASZ2_RS04970	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
CASZ2_RS04975	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
CASZ2_RS04980	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
CASZ2_RS04985	ENOG4107WHG	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
CASZ2_RS05020	ENOG410667J	hydrolase
CASZ2_RS05030	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
CASZ2_RS05050	ENOG4105DFA	alanine racemase domain protein
CASZ2_RS05065	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
CASZ2_RS05080	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
CASZ2_RS05090	ENOG4105C54	Major Facilitator superfamily
CASZ2_RS05100	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
CASZ2_RS05120	ENOG4108RWI	nicotinamidase
CASZ2_RS05125	ENOG4105CPC	Aldo Keto reductase
CASZ2_RS05130	ENOG4105CPC	Aldo Keto reductase
CASZ2_RS05135	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
CASZ2_RS05140	ENOG4105CXT	aspartate transcarbamylase
CASZ2_RS05145	ENOG4105CD3	dihydroorotase
CASZ2_RS05150	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
CASZ2_RS05155	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
CASZ2_RS05160	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
CASZ2_RS05165	ENOG4107TYT	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
CASZ2_RS05170	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
CASZ2_RS05175	ENOG4107T52	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
CASZ2_RS05185	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
CASZ2_RS05195	ENOG4105CEV	competence damage-inducible protein
CASZ2_RS05200	ENOG4105WBV	Transcriptional regulator
CASZ2_RS05220	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
CASZ2_RS05230	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
CASZ2_RS05235	ENOG4107WI4	Aldose-1-epimerase
CASZ2_RS05240	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
CASZ2_RS05245	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
CASZ2_RS05255	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
CASZ2_RS05260	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
CASZ2_RS05265	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
CASZ2_RS05275	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
CASZ2_RS05285	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
CASZ2_RS05290	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CASZ2_RS05305	ENOG4105CQ7	ATP-dependent helicase
CASZ2_RS05310	ENOG4105C29	acyl-CoA thioesterase
CASZ2_RS05315	ENOG4105I8R	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
CASZ2_RS05320	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
CASZ2_RS05330	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
CASZ2_RS05370	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CASZ2_RS05375	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
CASZ2_RS05385	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CASZ2_RS05405	ENOG4107W53	thymidine kinase
CASZ2_RS05430	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
CASZ2_RS05450	ENOG4107VEG	TrkA-N domain protein
CASZ2_RS05455	ENOG4105C0X	amino acid
CASZ2_RS05460	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
CASZ2_RS05465	ENOG4107QM5	aconitate hydratase
CASZ2_RS05470	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
CASZ2_RS05485	ENOG4105E0X	reductase
CASZ2_RS05495	ENOG4105WWK	YheO domain protein
CASZ2_RS05500	ENOG4105C0F	tryptophanase EC 4.1.99.1
CASZ2_RS05505	ENOG4105C85	amino acid
CASZ2_RS05510	ENOG4105CSR	polyphosphate kinase 2
CASZ2_RS05535	ENOG4105DQ4	alcohol dehydrogenase
CASZ2_RS05540	ENOG4105BZU	Histidine kinase
CASZ2_RS05550	ENOG4105C22	threonyL-tRNA synthetase
CASZ2_RS05585	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
CASZ2_RS05590	ENOG4108UW8	fha domain-containing protein
CASZ2_RS05610	ENOG4107H3J	ribonuclease
CASZ2_RS05620	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
CASZ2_RS05630	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
CASZ2_RS05640	ENOG4107TE5	Lipid kinase
CASZ2_RS05645	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
CASZ2_RS05655	ENOG4105CFG	Acts as a chaperone (By similarity)
CASZ2_RS05680	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
CASZ2_RS05695	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
CASZ2_RS05705	ENOG4107UVD	Beta-phosphoglucomutase family hydrolase
CASZ2_RS05725	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
CASZ2_RS05740	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
CASZ2_RS05755	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
CASZ2_RS05780	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CASZ2_RS05785	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
CASZ2_RS05790	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CASZ2_RS05800	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
CASZ2_RS05820	ENOG4105DK0	Indole-3-glycerol phosphate synthase
CASZ2_RS05825	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
CASZ2_RS05835	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
CASZ2_RS05840	ENOG4105CBC	glutamate synthase
CASZ2_RS05855	ENOG4107QK9	Beta-lactamase
CASZ2_RS05865	ENOG4106KNT	transcriptional regulator
CASZ2_RS05870	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CASZ2_RS05885	ENOG4105RD7	BadF BadG BcrA BcrD
CASZ2_RS05895	ENOG4105CS2	ec 3.2.1.21
CASZ2_RS05900	ENOG4105VZJ	PTS System
CASZ2_RS05905	ENOG4105CK1	PTS System
CASZ2_RS05910	ENOG4105VCP	PTS System
CASZ2_RS05930	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
CASZ2_RS05935	ENOG4105CIH	Imidazole acetol-phosphate transaminase
CASZ2_RS05940	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
CASZ2_RS05945	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
CASZ2_RS05950	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
CASZ2_RS05955	ENOG4105CDY	transcriptional regulatory protein
CASZ2_RS05960	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
CASZ2_RS05965	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
CASZ2_RS05970	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
CASZ2_RS05985	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
CASZ2_RS05990	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
CASZ2_RS06000	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
CASZ2_RS06005	ENOG4105C99	atpase involved in dna repair
CASZ2_RS06010	ENOG4105C5X	domain protein
CASZ2_RS06015	ENOG4105CUT	histidyl-tRNA synthetase
CASZ2_RS06025	ENOG4105KNA	-acetyltransferase
CASZ2_RS06045	ENOG4105C9M	aspartyl-trna synthetase
CASZ2_RS06060	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
CASZ2_RS06065	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
CASZ2_RS06070	ENOG4105HHA	aminodeoxychorismate lyase
CASZ2_RS06075	ENOG4105E2X	shikimate dehydrogenase
CASZ2_RS06080	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
CASZ2_RS06085	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
CASZ2_RS06090	ENOG4105D49	3-dehydroquinate synthase
CASZ2_RS06105	ENOG4105CSR	polyphosphate kinase 2
CASZ2_RS06110	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
CASZ2_RS06115	ENOG410803B	Involved in the transcription termination process (By similarity)
CASZ2_RS06125	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
CASZ2_RS06130	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
CASZ2_RS06140	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
CASZ2_RS06150	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
CASZ2_RS06170	ENOG4105DJV	ribulose-phosphate 3-epimerase
CASZ2_RS06190	ENOG4105ECB	domain protein
CASZ2_RS06195	ENOG4105C2J	ABC transporter
CASZ2_RS06205	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
CASZ2_RS06215	ENOG4105CAT	Cytidine monophosphate kinase
CASZ2_RS06220	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
CASZ2_RS06240	ENOG4105EDR	glucose galactose transporter
CASZ2_RS06245	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
CASZ2_RS06250	ENOG4105DKT	Transcriptional regulator
CASZ2_RS06260	ENOG4105CYC	Transferase
CASZ2_RS06285	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
CASZ2_RS06290	ENOG4105Q70	
CASZ2_RS06300	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
CASZ2_RS06315	ENOG4105PGM	cation diffusion facilitator family transporter
CASZ2_RS06335	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
CASZ2_RS06340	ENOG4105DXB	Major Facilitator superfamily
CASZ2_RS06370	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
CASZ2_RS06375	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
CASZ2_RS06380	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
CASZ2_RS06385	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
CASZ2_RS06390	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
CASZ2_RS06395	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
CASZ2_RS06400	ENOG4106DE0	ATP synthase
CASZ2_RS06405	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
CASZ2_RS06420	ENOG4105ESV	Glycosyl transferase, family 4
CASZ2_RS06430	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
CASZ2_RS06435	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
CASZ2_RS06440	ENOG4105VFB	Binds the 23S rRNA (By similarity)
CASZ2_RS06450	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
CASZ2_RS06455	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
CASZ2_RS06460	ENOG4105D6E	homoserine dehydrogenase
CASZ2_RS06480	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
CASZ2_RS06510	ENOG4105EMN	RNA polymerase sigma factor
CASZ2_RS06520	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
CASZ2_RS06525	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
CASZ2_RS06535	ENOG4107TK4	histidinol-phosphate phosphatase
CASZ2_RS06540	ENOG4108JQ1	Dehydrogenase
CASZ2_RS06545	ENOG4108JQ7	(ABC) transporter
CASZ2_RS06555	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CASZ2_RS06560	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
CASZ2_RS06565	ENOG4105DEF	Extracellular solute-binding protein, family 5
CASZ2_RS06755	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
CASZ2_RS06780	ENOG4105DSY	exodeoxyribonuclease V, gamma
CASZ2_RS06785	ENOG4107QKA	exodeoxyribonuclease V beta
CASZ2_RS06790	ENOG4105C7H	Helicase, RecD TraA family
CASZ2_RS06835	ENOG4105C31	Tryptophanyl-tRNA synthetase
CASZ2_RS06840	ENOG4105DB7	PHP domain protein
CASZ2_RS06845	ENOG4105C7I	Dehydrogenase
CASZ2_RS06865	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
CASZ2_RS06870	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
CASZ2_RS06880	ENOG4105G3P	Lipoprotein lpqB
CASZ2_RS06885	ENOG4105BZU	Histidine kinase
CASZ2_RS06890	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CASZ2_RS06895	ENOG4108UJU	UPF0301 protein
CASZ2_RS06975	ENOG4105CH7	arginosuccinase
CASZ2_RS06980	ENOG4105C8Y	Acetylornithine aminotransferase
CASZ2_RS06985	ENOG4105CAS	nag kinase
CASZ2_RS06990	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
CASZ2_RS06995	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
CASZ2_RS07000	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
CASZ2_RS07005	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
CASZ2_RS07010	ENOG4105CAK	Cell division ATP-binding protein ftsE
CASZ2_RS07015	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
CASZ2_RS07030	ENOG4107QZI	cell division protein FtsK
CASZ2_RS07050	ENOG4105CPF	Cell wall formation (By similarity)
CASZ2_RS07060	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
CASZ2_RS07065	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
CASZ2_RS07070	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
CASZ2_RS07075	ENOG41069M3	Transcriptional regulator
CASZ2_RS07090	ENOG4107FCW	Abortive infection protein
CASZ2_RS07105	ENOG4105CM2	brancheD-chain amino acid aminotransferase
CASZ2_RS07110	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
CASZ2_RS07115	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
CASZ2_RS07125	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
CASZ2_RS07135	ENOG4105C7K	acetolactate synthase
CASZ2_RS07140	ENOG4107YU2	histidine triad (hIT) protein
CASZ2_RS07145	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
CASZ2_RS07150	ENOG4105CQR	helicase
CASZ2_RS07160	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
CASZ2_RS07165	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
CASZ2_RS07185	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
CASZ2_RS07190	ENOG41081K0	peptidylprolyl cis-trans isomerase
CASZ2_RS07215	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CASZ2_RS07220	ENOG4108YZ4	nudix hydrolase
CASZ2_RS07225	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
CASZ2_RS07245	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
CASZ2_RS07250	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
CASZ2_RS07265	ENOG4108JJB	ABC transporter
CASZ2_RS07270	ENOG4107ZYJ	bioY protein
CASZ2_RS07275	ENOG4105DSU	hydrolase
CASZ2_RS07300	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
CASZ2_RS07315	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
CASZ2_RS07320	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
CASZ2_RS07325	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
CASZ2_RS07335	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
CASZ2_RS07340	ENOG41084BS	50S ribosomal protein L35
CASZ2_RS07345	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
CASZ2_RS07360	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
CASZ2_RS07365	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
CASZ2_RS07385	ENOG4105CPC	Aldo Keto reductase
CASZ2_RS07390	ENOG4105BZN	citrate synthase
CASZ2_RS07395	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
CASZ2_RS07420	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
CASZ2_RS07435	ENOG41080R2	UPF0102 protein
CASZ2_RS07445	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CASZ2_RS07450	ENOG4107QYR	Signal peptidase i
CASZ2_RS07455	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
CASZ2_RS07465	ENOG4105E33	succinate dehydrogenase
CASZ2_RS07480	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
CASZ2_RS07485	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
CASZ2_RS07490	ENOG41082KU	UPF0109 protein
CASZ2_RS07495	ENOG4105K5M	30s ribosomal protein S16
CASZ2_RS07545	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
CASZ2_RS07550	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
CASZ2_RS07555	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
CASZ2_RS07560	ENOG41084BZ	50S ribosomal protein L32
CASZ2_RS07580	ENOG4105DRS	transport system, permease
CASZ2_RS07585	ENOG4105ETE	Transcriptional regulator (LacI family
CASZ2_RS07615	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
CASZ2_RS07650	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
CASZ2_RS07670	ENOG4105VB9	50S ribosomal protein l28
CASZ2_RS07675	ENOG4105CN5	Metallo-Beta-Lactamase
CASZ2_RS07685	ENOG4105C7K	acetolactate synthase
CASZ2_RS07695	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
CASZ2_RS07700	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
CASZ2_RS07705	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
CASZ2_RS07725	ENOG4108IJ7	Glycine betaine
CASZ2_RS07730	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
CASZ2_RS07755	ENOG410787A	Pts system, glucitol sorbitol-specific
CASZ2_RS07760	ENOG4105DZY	Pts system, glucitol sorbitol-specific
CASZ2_RS07765	ENOG4105VI0	Pts system, glucitol sorbitol-specific
CASZ2_RS07775	ENOG4108MDK	Dehydrogenase
CASZ2_RS07780	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
CASZ2_RS07795	ENOG4105CJ1	ABC, transporter
CASZ2_RS07800	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
CASZ2_RS07810	ENOG4105CHV	Transcription elongation factor NusA
CASZ2_RS07815	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
CASZ2_RS07825	ENOG4105EJ9	Membrane
CASZ2_RS07835	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
CASZ2_RS07845	ENOG4105DSE	periplasmic solute binding protein
CASZ2_RS07845	ENOG4105DSE	periplasmic solute binding protein
CASZ2_RS07860	ENOG4105CC5	ABC transporter
CASZ2_RS07870	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
CASZ2_RS07885	ENOG4105DZP	Membrane-associated zinc metalloprotease
CASZ2_RS07890	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
CASZ2_RS07905	ENOG4107R37	Glutamate dehydrogenase
CASZ2_RS07910	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
CASZ2_RS07915	ENOG4105RXK	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
CASZ2_RS07925	ENOG4105KNE	Phosphatidate cytidylyltransferase
CASZ2_RS07930	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
CASZ2_RS07935	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
CASZ2_RS07940	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
CASZ2_RS07945	ENOG4105CE9	30S ribosomal protein S2
CASZ2_RS07950	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CASZ2_RS07965	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
CASZ2_RS07975	ENOG4105DHU	Bile acid
CASZ2_RS07990	ENOG4105DKW	ABC transporter
CASZ2_RS08000	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
CASZ2_RS08005	ENOG4105CHR	reductase
CASZ2_RS08030	ENOG4105C5H	ABC transporter
CASZ2_RS08055	ENOG4108UNV	SUF system FeS assembly protein, NifU family
CASZ2_RS08060	ENOG4105C9B	Cysteine desulfurase
CASZ2_RS08065	ENOG4105C3K	feS assembly ATPase SufC
CASZ2_RS08080	ENOG4105DIW	FeS assembly protein SUFB
CASZ2_RS08100	ENOG4105D56	permease protein
CASZ2_RS08115	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CASZ2_RS08120	ENOG4108M15	ABC transporter
CASZ2_RS08140	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
CASZ2_RS08160	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
CASZ2_RS08175	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
CASZ2_RS08180	ENOG4105ESP	cell wall surface anchor family protein
CASZ2_RS08185	ENOG4107RE3	peptidase, S41
CASZ2_RS08190	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
CASZ2_RS08195	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
CASZ2_RS08200	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
CASZ2_RS08205	ENOG4105DSF	transport protein
CASZ2_RS08210	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
CASZ2_RS08225	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
CASZ2_RS08240	ENOG4107QRT	dEAD DEAH box helicase
CASZ2_RS08270	ENOG4105CRK	lysyL-tRNA synthetase
CASZ2_RS08290	ENOG4108YZG	isomerase
CASZ2_RS08295	ENOG4105HHS	UPF0256 protein
CASZ2_RS08300	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
CASZ2_RS08320	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
CASZ2_RS08325	ENOG4105CG3	alpha amylase, catalytic region
CASZ2_RS08400	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
CASZ2_RS08410	ENOG4105C85	amino acid
CASZ2_RS08415	ENOG4108UGD	Serine Threonine protein kinase
CASZ2_RS08420	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
CASZ2_RS08450	ENOG4105C0B	DNA polymerase III (alpha subunit)
CASZ2_RS08470	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
CASZ2_RS08485	ENOG4107T3P	ABC, transporter
CASZ2_RS08570	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
CASZ2_RS08580	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
CASZ2_RS08585	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
CASZ2_RS08590	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
CASZ2_RS08595	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
CASZ2_RS08605	ENOG4105CE1	Ferrous iron transport protein b
CASZ2_RS08620	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
CASZ2_RS08650	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
CASZ2_RS08665	ENOG4105W49	UPF0434 protein
CASZ2_RS08690	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
CASZ2_RS08700	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
CASZ2_RS08720	ENOG4108KGH	TRANSCRIPTIONal
CASZ2_RS08745	ENOG4105EC3	peptidase S51, dipeptidase E
CASZ2_RS08760	ENOG4105D8K	carboxyl transferase
CASZ2_RS08770	ENOG4107WR6	Maf-like protein
CASZ2_RS08785	ENOG4105EMU	Dehydrogenase
CASZ2_RS08790	ENOG4105DWF	phosphomethylpyrimidine kinase
CASZ2_RS08815	ENOG4105D7N	magnesium and cobalt transport protein CorA
CASZ2_RS08830	ENOG4108JIK	carboxylase
CASZ2_RS08850	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
CASZ2_RS08855	ENOG4105CEY	Amp-dependent synthetase and ligase
CASZ2_RS08875	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
CASZ2_RS08880	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CASZ2_RS08895	ENOG4105UIB	(ABC) transporter
CASZ2_RS08900	ENOG4108JQ9	ABC transporter
CASZ2_RS08905	ENOG4105DIH	basic membrane
CASZ2_RS08925	ENOG4105E9K	Isocitrate dehydrogenase
CASZ2_RS08940	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
CASZ2_RS08945	ENOG4108EKI	Dehydrogenase
CASZ2_RS08955	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
CASZ2_RS08980	ENOG4105DC1	bifunctional purine biosynthesis protein purh
CASZ2_RS08990	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
CASZ2_RS08995	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
CASZ2_RS09005	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
CASZ2_RS09020	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
CASZ2_RS09035	ENOG4105D01	(LipO)protein
CASZ2_RS09040	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
CASZ2_RS09045	ENOG4108UMI	ABC transporter, permease
CASZ2_RS09065	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
CASZ2_RS09075	ENOG4105D7W	serine acetyltransferase
CASZ2_RS09080	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
CASZ2_RS09085	ENOG4107QVP	Dehydrogenase
CASZ2_RS09090	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CASZ2_RS09095	ENOG41090CE	integral membrane protein
CASZ2_RS09105	ENOG4105BZG	amino acid carrier protein
CASZ2_RS09115	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
CASZ2_RS09120	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
CASZ2_RS09145	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
CASZ2_RS09150	ENOG4105EHG	Permease protein
CASZ2_RS09165	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CASZ2_RS09180	ENOG4108097	ATP-binding protein
CASZ2_RS09190	ENOG4105C1J	atp-dependent rna helicase
CASZ2_RS09205	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CASZ2_RS09210	ENOG4105BZF	Glycosyl transferase (Group 1
CASZ2_RS09220	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
CASZ2_RS09225	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
CASZ2_RS09240	ENOG4105CS9	pantothenic acid kinase
CASZ2_RS09255	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
CASZ2_RS09260	ENOG4108UJD	30S ribosomal protein S9
CASZ2_RS09265	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
CASZ2_RS09285	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
CASZ2_RS09290	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
CASZ2_RS09295	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
CASZ2_RS09305	ENOG4105BZ1	(ABC) transporter
CASZ2_RS09315	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
CASZ2_RS09330	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
CASZ2_RS09350	ENOG4105C54	Major Facilitator superfamily
CASZ2_RS09360	ENOG4108MJN	Glycosyl Transferase
CASZ2_RS09365	ENOG4108ZT0	50S ribosomal protein l17
CASZ2_RS09370	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CASZ2_RS09375	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
CASZ2_RS09380	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
CASZ2_RS09385	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CASZ2_RS09390	ENOG41067V7	50S ribosomal protein L36
CASZ2_RS09395	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
CASZ2_RS09405	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
CASZ2_RS09425	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
CASZ2_RS09445	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
CASZ2_RS09450	ENOG410849U	50S ribosomal protein L30
CASZ2_RS09455	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
CASZ2_RS09460	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
CASZ2_RS09465	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
CASZ2_RS09470	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
CASZ2_RS09475	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
CASZ2_RS09480	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CASZ2_RS09485	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
CASZ2_RS09490	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
CASZ2_RS09495	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
CASZ2_RS09500	ENOG41082SA	50s ribosomal protein l29
CASZ2_RS09505	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
CASZ2_RS09510	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
CASZ2_RS09515	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
CASZ2_RS09520	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
CASZ2_RS09525	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CASZ2_RS09530	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
CASZ2_RS09535	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
CASZ2_RS09540	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
CASZ2_RS09545	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
CASZ2_RS09550	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
CASZ2_RS09565	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
CASZ2_RS09570	ENOG4105CX6	glutaminyL-tRNA synthetase
CASZ2_RS09575	ENOG4105CGH	5'-nucleotidase
CASZ2_RS09585	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
CASZ2_RS09600	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
CASZ2_RS09605	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
CASZ2_RS09610	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
CASZ2_RS09630	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CASZ2_RS09635	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CASZ2_RS09640	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
CASZ2_RS09645	ENOG4108VZM	50s ribosomal protein L10
CASZ2_RS09650	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
CASZ2_RS09655	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
CASZ2_RS09660	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
CASZ2_RS09665	ENOG410683Z	Preprotein translocase SecE subunit
CASZ2_RS09675	ENOG4105XT2	Transcriptional regulator
CASZ2_RS09680	ENOG4107R4N	Cell wall formation (By similarity)
CASZ2_RS09690	ENOG410900P	UPF0336 protein
CASZ2_RS09695	ENOG4105WDJ	50S ribosomal protein L33
CASZ2_RS09715	ENOG4105CGK	Exodeoxyribonuclease III
CASZ2_RS09720	ENOG4105CGU	Enoyl-CoA hydratase
CASZ2_RS09730	ENOG4108M11	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09735	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09740	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09745	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
CASZ2_RS09750	ENOG4105DQU	oxidoreductase, subunit beta
CASZ2_RS09775	ENOG4105C9K	Endothelin-converting enzyme 1
CASZ2_RS09785	ENOG4105CDA	abc transporter atp-binding protein
CASZ2_RS09800	ENOG4105CJ1	ABC, transporter
CASZ2_RS09820	ENOG4105CI0	Citrate lyase
CASZ2_RS09840	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09855	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09860	ENOG4105DF2	NADH dehydrogenase subunit j
CASZ2_RS09865	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09870	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
CASZ2_RS09875	ENOG4108IEH	NADH dehydrogenase subunit g
CASZ2_RS09880	ENOG4107QIZ	NADH dehydrogenase
CASZ2_RS09890	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09895	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CASZ2_RS09900	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CASZ2_RS09910	ENOG4105P52	geranylgeranyl reductase
CASZ2_RS09935	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
CASZ2_RS09945	ENOG4105BZ1	(ABC) transporter
CASZ2_RS09955	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CASZ2_RS09975	ENOG4105CMT	Dihydroxyacetone kinase
CASZ2_RS09980	ENOG4108UTZ	Dihydroxyacetone kinase
CASZ2_RS09985	ENOG4105VDH	Dihydroxyacetone kinase
CASZ2_RS10005	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
CASZ2_RS10035	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
CASZ2_RS10040	ENOG4105DRS	transport system, permease
CASZ2_RS10075	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
CASZ2_RS10080	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
CASZ2_RS10100	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
CASZ2_RS10115	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
CASZ2_RS10140	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
CASZ2_RS10165	ENOG4107QN2	dihydrolipoyl dehydrogenase
CASZ2_RS10190	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
CASZ2_RS10195	ENOG4105C8V	SAICAR synthetase
CASZ2_RS10200	ENOG4105D3R	alkyl hydroperoxide reductase
CASZ2_RS10205	ENOG4108JU3	Alkyl hydroperoxide reductase
CASZ2_RS10210	ENOG4105C5Q	Transcriptional regulator
CASZ2_RS10215	ENOG4105C83	adenylosuccinate lyase
CASZ2_RS10220	ENOG4105C12	Phosphoribosylglycinamide synthetase
CASZ2_RS10225	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
CASZ2_RS10235	ENOG4105FDP	GntR family transcriptional regulator
CASZ2_RS10240	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
CASZ2_RS10245	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
CASZ2_RS10265	ENOG4105CI3	gtp-binding protein typa
CASZ2_RS10275	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
CASZ2_RS10280	ENOG4107QX3	carboxylase
CASZ2_RS10285	ENOG4107QX3	carboxylase
CASZ2_RS10290	ENOG4107QSA	Oxaloacetate decarboxylase
CASZ2_RS10295	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
CASZ2_RS10305	ENOG4107RCW	fructose-bisphosphate aldolase
CASZ2_RS10320	ENOG4105DQR	SNARE associated Golgi
CASZ2_RS10340	ENOG4105K5B	UPF0225 protein
CASZ2_RS10345	ENOG41079KZ	Major Facilitator Superfamily
CASZ2_RS10350	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
CASZ2_RS10365	ENOG4105WYW	fructose-bisphosphate aldolase
CASZ2_RS10380	ENOG4105BZU	Histidine kinase
CASZ2_RS10385	ENOG4105WH1	Two component transcriptional regulator luxr family
CASZ2_RS10390	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
CASZ2_RS10395	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
CASZ2_RS10400	ENOG41061Y6	folic acid biosynthetic process
CASZ2_RS10405	ENOG4105C85	amino acid
CASZ2_RS10410	ENOG4107WGA	YidE YbjL
CASZ2_RS10415	ENOG4105CPQ	Dehydrogenase
CASZ2_RS10425	ENOG4105KNI	merR family transcriptional Regulator
CASZ2_RS10430	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
CASZ2_RS10435	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CASZ2_RS10440	ENOG4105CFG	Acts as a chaperone (By similarity)
CASZ2_RS10455	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
CASZ2_RS10465	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
CASZ2_RS10480	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
CASZ2_RS10485	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
CASZ2_RS10495	ENOG4105EAC	phosphoserine phosphatase
CASZ2_RS10500	ENOG4105DSB	aldose 1-epimerase
CASZ2_RS10510	ENOG4105DV0	amidase (EC 3.5.1.4
CASZ2_RS10535	ENOG4105DU0	nucleoside hydrolase
CASZ2_RS10550	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
CASZ2_RS10595	ENOG4105CJ1	ABC, transporter
CASZ2_RS10605	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
CASZ2_RS10610	ENOG4105CPP	Dehydrogenase, E1 component
CASZ2_RS10620	ENOG4105C1Q	protoporphyrinogen oxidase
CASZ2_RS10645	ENOG4105BZ1	(ABC) transporter
CASZ2_RS10665	ENOG4105D29	Helix-turn-helix type 11 domain protein
CASZ2_RS10715	ENOG4105KJF	protein tyrosine phosphatase
CASZ2_RS10730	ENOG41062D9	Histidine kinase
CASZ2_RS10740	ENOG4105D44	asparaginase
CASZ2_RS10745	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
CASZ2_RS10760	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
CASZ2_RS10770	ENOG4105CSH	Transporter
CASZ2_RS10775	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CASZ2_RS10780	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CASZ2_RS10805	ENOG4108638	50S ribosomal protein L36
CASZ2_RS10810	ENOG4105DBV	ornithine carbamoyltransferase
CASZ2_RS10820	ENOG4105C75	arginyL-tRNA synthetase
CASZ2_RS10825	ENOG4105CV8	reductase
CASZ2_RS10835	ENOG4107QP8	phosphohexose isomerase
CASZ2_RS10850	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
CASZ2_RS10855	ENOG4105CQR	helicase
CASZ2_RS10860	ENOG4105F1A	Pyruvate formate-lyase
CASZ2_RS10865	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
CASZ2_RS10915	ENOG4108PJD	permease
CASZ2_RS10935	ENOG4105CFH	Aspartokinase
CASZ2_RS10940	ENOG4105BZ4	penicillin-binding protein
CASZ2_RS10955	ENOG4108Z0Z	intracellular protease Pfpi family
CASZ2_RS10960	ENOG4105DEF	Extracellular solute-binding protein, family 5
CASZ2_RS10965	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
CASZ2_RS10970	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
CASZ2_RS10975	ENOG4105C3U	ABC transporter
CASZ2_RS10980	ENOG4108JQ7	(ABC) transporter
CASZ2_RS10985	ENOG4105NRA	50s ribosomal protein l31 type b
CASZ2_RS10990	ENOG4105KDC	50s ribosomal protein l28
CASZ2_RS10995	ENOG4105W0E	50S ribosomal protein L33
CASZ2_RS11000	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
CASZ2_RS11005	ENOG41068HZ	50S ribosomal protein L32
CASZ2_RS11015	ENOG4105D17	glycoside hydrolase, family 3 domain protein
CASZ2_RS11020	ENOG4105CGP	Urocanate hydratase
CASZ2_RS11030	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
CASZ2_RS11035	ENOG4105CI2	imidazolone-5-propionate hydrolase
CASZ2_RS11040	ENOG4105C84	Histidine ammonia-lyase
CASZ2_RS11090	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
CASZ2_RS11110	ENOG4108Z6B	deaminase
CASZ2_RS11120	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
CASZ2_RS11140	ENOG4105DFH	Transport of potassium into the cell (By similarity)
CASZ2_RS11145	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
CASZ2_RS11170	ENOG4105ETE	Transcriptional regulator (LacI family
CASZ2_RS11175	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
CASZ2_RS11215	ENOG4105CDH	Citrulline--aspartate ligase
CASZ2_RS11240	ENOG410667J	hydrolase
CASZ2_RS11280	ENOG4105ETS	cytosine purines uracil thiamine allantoin
CASZ2_RS11290	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
CASZ2_RS11325	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
CASZ2_RS11340	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
CASZ2_RS11360	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
CASZ2_RS11365	ENOG41090A1	ferritin
CASZ2_RS11380	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
CASZ2_RS11385	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
CASZ2_RS11395	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
CASZ2_RS11410	ENOG4105DM4	PTS System
CASZ2_RS11415	ENOG4105DM4	PTS System
CASZ2_RS11425	ENOG4108IQE	Amp-dependent synthetase and ligase
CASZ2_RS11430	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
CASZ2_RS11450	ENOG4105K6T	rare lipoprotein A
CASZ2_RS11460	ENOG410681U	heavy metal transport detoxification protein
CASZ2_RS11465	ENOG4105VPX	protein, conserved in bacteria
CASZ2_RS11470	ENOG4105CDU	Replicative dna helicase
CASZ2_RS11500	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
CASZ2_RS11505	ENOG4105C5I	Dehydrogenase
CASZ2_RS11510	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
CASZ2_RS11520	ENOG4105C85	amino acid
CASZ2_RS11540	ENOG4107QI1	Mate efflux family protein
CASZ2_RS11555	ENOG4108Z66	YbaK ebsC protein
CASZ2_RS11580	ENOG4105CTQ	phosphohexokinase
CASZ2_RS11615	ENOG4107UBC	ErfK ybiS ycfS ynhG family protein
CASZ2_RS11620	ENOG4105K6T	rare lipoprotein A
CASZ2_RS11630	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
CASZ2_RS11665	ENOG4107UBC	ErfK ybiS ycfS ynhG family protein
CASZ2_RS11670	ENOG4105K6T	rare lipoprotein A
CASZ2_RS11680	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
CASZ2_RS11685	ENOG4105DCF	alanine dehydrogenase
CASZ2_RS11705	ENOG4105Z5Q	
CASZ2_RS11715	ENOG4105KIJ	D-ornithine aminomutase S component
CASZ2_RS11720	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
CASZ2_RS11730	ENOG4106M28	alanine racemase domain protein
CASZ2_RS11735	ENOG4105C85	amino acid
CASZ2_RS11740	ENOG4105C85	amino acid
CASZ2_RS11745	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
CASZ2_RS11755	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
CASZ2_RS11780	ENOG4105C9Q	fumarate hydratase class II
CASZ2_RS11785	ENOG4105DRS	transport system, permease
CASZ2_RS11800	ENOG4105ETE	Transcriptional regulator (LacI family
CASZ2_RS11810	ENOG4105D8X	mechanosensitive ion channel
CASZ2_RS11815	ENOG4105BZW	Glycerate kinase
CASZ2_RS11825	ENOG4105DJ0	Poly(A) Polymerase
CASZ2_RS11840	ENOG4107TPY	serine threonine protein kinase
CASZ2_RS11845	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
CASZ2_RS11850	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
CASZ2_RS11860	ENOG4105C0H	protease
CASZ2_RS11875	ENOG4105C3M	thioredoxin reductase
CASZ2_RS11905	ENOG4105K63	Thioredoxin
CASZ2_RS11910	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
CASZ2_RS11935	ENOG4105EF1	ribulokinase
CASZ2_RS11940	ENOG4108MDK	Dehydrogenase
CASZ2_RS11960	ENOG4107YVI	ribose 5-phosphate isomerase
CASZ2_RS11970	ENOG4105E98	transcriptional regulator DeoR family
CASZ2_RS11975	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
CASZ2_RS11980	ENOG4105DEI	Mannitol dehydrogenase
CASZ2_RS11985	ENOG4105D2H	Uronic isomerase
CASZ2_RS11990	ENOG4105ETE	Transcriptional regulator (LacI family
CASZ2_RS11995	ENOG4105CT4	transporter
CASZ2_RS12005	ENOG4105CNT	hydrolase family 2
CASZ2_RS12030	ENOG4105CPF	Cell wall formation (By similarity)
CASZ2_RS12040	ENOG4105VCH	membrane
CASZ2_RS12045	ENOG4105FA0	parb-like partition protein
CASZ2_RS12075	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
CASZ2_RS12115	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CASZ2_RS12120	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
CASZ2_RS12130	ENOG41084CH	50S ribosomal protein l34