locus-tag	class	description
CASZ2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CASZ2_RS00010	COG0592	DNA-directed DNA polymerase activity
CASZ2_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CASZ2_RS00045	COG1482	cell wall glycoprotein biosynthetic process
CASZ2_RS00050	COG0187	DNA topoisomerase II activity
CASZ2_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CASZ2_RS00060	COG3266	domain, Protein
CASZ2_RS00065	COG0039	L-malate dehydrogenase activity
CASZ2_RS00070	COG1609	Transcriptional regulator
CASZ2_RS00075	COG1129	ABC transporter
CASZ2_RS00080	COG1172	Belongs to the binding-protein-dependent transport system permease family
CASZ2_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CASZ2_RS00095	COG1869	D-ribose catabolic process
CASZ2_RS00115	COG3775	system Galactitol-specific IIC component
CASZ2_RS00120	COG3414	Phosphotransferase system galactitol-specific IIB component
CASZ2_RS00125	COG1063	alcohol dehydrogenase
CASZ2_RS00175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CASZ2_RS00245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CASZ2_RS00265	COG4591	ABC-type transport system involved in lipoprotein release permease component
CASZ2_RS00270	COG0577	efflux transmembrane transporter activity
CASZ2_RS00270	COG1136	(ABC) transporter
CASZ2_RS00275	COG2197	response regulator
CASZ2_RS00285	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS00290	COG1175	transmembrane transport
CASZ2_RS00300	COG1349	DNA-binding transcription factor activity
CASZ2_RS00330	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CASZ2_RS00340	COG4585	Histidine kinase
CASZ2_RS00350	COG1309	transcriptional regulator
CASZ2_RS00355	COG2409	Drug exporters of the RND superfamily
CASZ2_RS00375	COG1136	(ABC) transporter
CASZ2_RS00390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CASZ2_RS00410	COG0058	SHG alpha-glucan phosphorylase activity
CASZ2_RS00425	COG5426	von Willebrand factor, type A
CASZ2_RS00440	COG1175	transmembrane transport
CASZ2_RS00445	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS00470	COG0205	6-phosphofructokinase activity
CASZ2_RS00490	COG1027	Aspartate ammonia-lyase
CASZ2_RS00495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CASZ2_RS00510	COG1132	(ABC) transporter
CASZ2_RS00515	COG1132	(ABC) transporter
CASZ2_RS00520	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CASZ2_RS00535	COG0641	radical SAM
CASZ2_RS00540	COG1120	ATPase activity
CASZ2_RS00555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CASZ2_RS00565	COG4716	Myosin-crossreactive antigen
CASZ2_RS00570	COG0351	phosphomethylpyrimidine kinase
CASZ2_RS00570	COG0352	thiamine-phosphate diphosphorylase activity
CASZ2_RS00570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CASZ2_RS00580	COG0352	thiamine-phosphate diphosphorylase activity
CASZ2_RS00600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CASZ2_RS00610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CASZ2_RS00655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CASZ2_RS00680	COG0438	transferase activity, transferring glycosyl groups
CASZ2_RS00715	COG3104	oligopeptide transport
CASZ2_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
CASZ2_RS00735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS00735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS00740	COG1105	Belongs to the carbohydrate kinase PfkB family
CASZ2_RS00755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CASZ2_RS00765	COG0438	transferase activity, transferring glycosyl groups
CASZ2_RS00775	COG0297	glycogen (starch) synthase activity
CASZ2_RS00795	COG1252	NADH dehydrogenase
CASZ2_RS00805	COG1643	Atp-dependent helicase
CASZ2_RS00810	COG4721	ABC-type cobalt transport system, permease component
CASZ2_RS00815	COG1129	ABC transporter
CASZ2_RS00835	COG0167	dihydroorotate dehydrogenase activity
CASZ2_RS00840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CASZ2_RS00840	COG1013	pyruvate-flavodoxin oxidoreductase activity
CASZ2_RS00840	COG0674	pyruvate-flavodoxin oxidoreductase activity
CASZ2_RS00840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CASZ2_RS00860	COG1620	l-lactate permease
CASZ2_RS00865	COG0247	lactate metabolic process
CASZ2_RS00870	COG1139	Iron-sulfur cluster binding protein
CASZ2_RS00875	COG1556	Lactate utilization protein
CASZ2_RS00880	COG1122	ATPase activity
CASZ2_RS00895	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CASZ2_RS00900	COG4988	ABC transporter
CASZ2_RS00905	COG1294	oxidase, subunit
CASZ2_RS00910	COG1271	oxidase subunit
CASZ2_RS00945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CASZ2_RS00960	COG2815	serine threonine protein kinase
CASZ2_RS00960	COG0515	serine threonine protein kinase
CASZ2_RS00965	COG0768	penicillin binding
CASZ2_RS00980	COG1716	ATPase activity
CASZ2_RS01090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CASZ2_RS01095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CASZ2_RS01105	COG1136	(ABC) transporter
CASZ2_RS01105	COG0577	efflux transmembrane transporter activity
CASZ2_RS01120	COG0561	phosphatase activity
CASZ2_RS01125	COG0561	phosphatase activity
CASZ2_RS01130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CASZ2_RS01160	COG0814	amino acid
CASZ2_RS01170	COG0673	inositol 2-dehydrogenase activity
CASZ2_RS01205	COG0494	nUDIX hydrolase
CASZ2_RS01215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CASZ2_RS01270	COG1205	dead DEAH box helicase
CASZ2_RS01270	COG1111	helicase
CASZ2_RS01275	COG2890	protein-(glutamine-N5) methyltransferase activity
CASZ2_RS01285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CASZ2_RS01285	COG1754	DNA topoisomerase type I activity
CASZ2_RS01295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CASZ2_RS01300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CASZ2_RS01310	COG1774	PSP1 C-terminal conserved region
CASZ2_RS01335	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CASZ2_RS01350	COG3458	cephalosporin-C deacetylase activity
CASZ2_RS01360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CASZ2_RS01370	COG0037	tRNA processing
CASZ2_RS01385	COG0302	gtp cyclohydrolase
CASZ2_RS01425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CASZ2_RS01430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CASZ2_RS01450	COG0649	NAD binding
CASZ2_RS01480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CASZ2_RS01485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CASZ2_RS01490	COG1984	allophanate hydrolase subunit 2
CASZ2_RS01500	COG1090	epimerase
CASZ2_RS01505	COG0705	Rhomboid family
CASZ2_RS01515	COG2197	response regulator
CASZ2_RS01520	COG4585	Histidine kinase
CASZ2_RS01530	COG3711	transcriptional antiterminator
CASZ2_RS01535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CASZ2_RS01535	COG1263	PTS System
CASZ2_RS01535	COG2190	(PTS) system
CASZ2_RS01540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CASZ2_RS01540	COG1263	PTS System
CASZ2_RS01540	COG2190	(PTS) system
CASZ2_RS01555	COG1194	a g-specific adenine glycosylase
CASZ2_RS01560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CASZ2_RS01565	COG0113	porphobilinogen synthase activity
CASZ2_RS01575	COG0181	hydroxymethylbilane synthase activity
CASZ2_RS01585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CASZ2_RS01590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CASZ2_RS01610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CASZ2_RS01615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CASZ2_RS01630	COG1082	Xylose isomerase domain protein TIM barrel
CASZ2_RS01635	COG0506	proline dehydrogenase activity
CASZ2_RS01650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CASZ2_RS01670	COG0406	alpha-ribazole phosphatase activity
CASZ2_RS01675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CASZ2_RS01680	COG0785	Cytochrome C biogenesis protein
CASZ2_RS01685	COG1333	cytochrome c biogenesis protein
CASZ2_RS01690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CASZ2_RS01700	COG4221	oxidoreductase activity
CASZ2_RS01730	COG1120	ATPase activity
CASZ2_RS01735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CASZ2_RS01745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CASZ2_RS01770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CASZ2_RS01775	COG0745	RESPONSE REGULATOR receiver
CASZ2_RS01785	COG1490	D-aminoacyl-tRNA deacylase activity
CASZ2_RS01790	COG3485	protocatechuate 3,4-dioxygenase
CASZ2_RS01800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CASZ2_RS01810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CASZ2_RS01815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CASZ2_RS01820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CASZ2_RS01825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CASZ2_RS01840	COG1329	Transcriptional regulator
CASZ2_RS01875	COG0588	phosphoglycerate mutase activity
CASZ2_RS01890	COG0252	asparaginase activity
CASZ2_RS01895	COG1113	amino acid transport
CASZ2_RS01900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CASZ2_RS01905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CASZ2_RS01910	COG0800	Aldolase
CASZ2_RS01925	COG5492	domain, Protein
CASZ2_RS01950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CASZ2_RS01955	COG0215	cysteine-tRNA ligase activity
CASZ2_RS02010	COG3842	ATPase activity
CASZ2_RS02015	COG1760	l-serine dehydratase
CASZ2_RS02025	COG0673	inositol 2-dehydrogenase activity
CASZ2_RS02030	COG2182	Extracellular solute-binding protein
CASZ2_RS02035	COG1175	transmembrane transport
CASZ2_RS02040	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS02045	COG1063	alcohol dehydrogenase
CASZ2_RS02060	COG1174	glycine betaine transport
CASZ2_RS02085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CASZ2_RS02090	COG2130	NADP-dependent
CASZ2_RS02095	COG1131	(ABC) transporter
CASZ2_RS02105	COG4585	Histidine kinase
CASZ2_RS02110	COG2197	response regulator
CASZ2_RS02115	COG0406	alpha-ribazole phosphatase activity
CASZ2_RS02120	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CASZ2_RS02125	COG1492	cobalamin metabolic process
CASZ2_RS02145	COG1648	precorrin-2 dehydrogenase activity
CASZ2_RS02145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CASZ2_RS02160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CASZ2_RS02165	COG1120	ATPase activity
CASZ2_RS02185	COG0310	cobalt ion transport
CASZ2_RS02220	COG1797	cobyrinic acid a,c-diamide synthase activity
CASZ2_RS02230	COG2099	Precorrin-6x reductase
CASZ2_RS02235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CASZ2_RS02280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CASZ2_RS02280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS02280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS02305	COG1854	S-ribosylhomocysteine lyase activity
CASZ2_RS02330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CASZ2_RS02340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CASZ2_RS02350	COG3718	enzyme involved in inositol metabolism
CASZ2_RS02355	COG3962	Belongs to the TPP enzyme family
CASZ2_RS02365	COG1012	belongs to the aldehyde dehydrogenase family
CASZ2_RS02370	COG1609	Transcriptional regulator
CASZ2_RS02380	COG1082	Xylose isomerase domain protein TIM barrel
CASZ2_RS02385	COG1082	Xylose isomerase domain protein TIM barrel
CASZ2_RS02390	COG0673	inositol 2-dehydrogenase activity
CASZ2_RS02395	COG2814	Major facilitator Superfamily
CASZ2_RS02410	COG1082	Xylose isomerase domain protein TIM barrel
CASZ2_RS02415	COG0673	inositol 2-dehydrogenase activity
CASZ2_RS02425	COG3142	Participates in the control of copper homeostasis
CASZ2_RS02435	COG1061	Type III restriction enzyme res subunit
CASZ2_RS02460	COG0363	glucosamine-6-phosphate deaminase activity
CASZ2_RS02465	COG1278	Cold shock
CASZ2_RS02480	COG2252	PERMEase
CASZ2_RS02495	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CASZ2_RS02520	COG2814	Major facilitator Superfamily
CASZ2_RS02540	COG1970	mechanosensitive ion channel activity
CASZ2_RS02555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CASZ2_RS02560	COG0303	'Molybdopterin
CASZ2_RS02585	COG0315	cyclic pyranopterin monophosphate synthase activity
CASZ2_RS02605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CASZ2_RS02640	COG1140	nitrate reductase beta subunit
CASZ2_RS02660	COG0315	cyclic pyranopterin monophosphate synthase activity
CASZ2_RS02660	COG0521	Mo-molybdopterin cofactor biosynthetic process
CASZ2_RS02675	COG0437	4 iron, 4 sulfur cluster binding
CASZ2_RS02680	COG0243	molybdopterin cofactor binding
CASZ2_RS02690	COG2022	thiamine diphosphate biosynthetic process
CASZ2_RS02700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CASZ2_RS02700	COG2022	thiamine diphosphate biosynthetic process
CASZ2_RS02705	COG0598	Magnesium transport protein CorA
CASZ2_RS02715	COG2233	PERMEase
CASZ2_RS02730	COG0084	hydrolase, TatD family'
CASZ2_RS02735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CASZ2_RS02740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CASZ2_RS02745	COG1846	Transcriptional regulator
CASZ2_RS02760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CASZ2_RS02765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CASZ2_RS02785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CASZ2_RS02790	COG0193	aminoacyl-tRNA hydrolase activity
CASZ2_RS02800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CASZ2_RS02840	COG0148	phosphopyruvate hydratase activity
CASZ2_RS02910	COG1297	OPT oligopeptide transporter protein
CASZ2_RS02915	COG0667	Aldo Keto reductase
CASZ2_RS02920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CASZ2_RS02925	COG0733	neurotransmitter:sodium symporter activity
CASZ2_RS02935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CASZ2_RS02955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CASZ2_RS02970	COG1331	Highly conserved protein containing a thioredoxin domain
CASZ2_RS02975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CASZ2_RS02985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CASZ2_RS02995	COG1722	exodeoxyribonuclease VII activity
CASZ2_RS03000	COG1570	exodeoxyribonuclease VII activity
CASZ2_RS03010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CASZ2_RS03015	COG1322	Protein conserved in bacteria
CASZ2_RS03020	COG1362	aminopeptidase activity
CASZ2_RS03025	COG0012	GTP binding
CASZ2_RS03045	COG1846	Transcriptional regulator
CASZ2_RS03050	COG1764	response to oxidative stress
CASZ2_RS03065	COG2235	arginine
CASZ2_RS03070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CASZ2_RS03090	COG3830	Belongs to the UPF0237 family
CASZ2_RS03095	COG0667	Aldo Keto reductase
CASZ2_RS03100	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CASZ2_RS03105	COG0833	amino acid
CASZ2_RS03110	COG0366	Alpha amylase catalytic
CASZ2_RS03110	COG3103	Sh3 type 3 domain protein
CASZ2_RS03145	COG1404	Belongs to the peptidase S8 family
CASZ2_RS03150	COG2501	S4 domain
CASZ2_RS03155	COG1126	abc transporter atp-binding protein
CASZ2_RS03185	COG1176	ABC-type spermidine putrescine transport system, permease component I
CASZ2_RS03190	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS03200	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
CASZ2_RS03225	COG1136	(ABC) transporter
CASZ2_RS03240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CASZ2_RS03245	COG1121	(ABC) transporter
CASZ2_RS03250	COG0803	Belongs to the bacterial solute-binding protein 9 family
CASZ2_RS03265	COG1012	belongs to the aldehyde dehydrogenase family
CASZ2_RS03270	COG1063	alcohol dehydrogenase
CASZ2_RS03275	COG2376	Dihydroxyacetone kinase
CASZ2_RS03280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CASZ2_RS03290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CASZ2_RS03295	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CASZ2_RS03300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CASZ2_RS03315	COG2171	N-acyltransferase activity
CASZ2_RS03325	COG1834	amidinotransferase
CASZ2_RS03335	COG0477	Major facilitator Superfamily
CASZ2_RS03360	COG0297	glycogen (starch) synthase activity
CASZ2_RS03365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CASZ2_RS03375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CASZ2_RS03380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CASZ2_RS03415	COG0006	proline dipeptidase activity
CASZ2_RS03450	COG4139	cobalamin transport
CASZ2_RS03455	COG1120	ATPase activity
CASZ2_RS03495	COG0174	glutamine synthetase
CASZ2_RS03505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CASZ2_RS03530	COG0174	glutamine synthetase
CASZ2_RS03540	COG0438	transferase activity, transferring glycosyl groups
CASZ2_RS03550	COG1263	PTS System
CASZ2_RS03555	COG2188	Transcriptional regulator
CASZ2_RS03560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CASZ2_RS03560	COG1263	PTS System
CASZ2_RS03565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CASZ2_RS03575	COG3477	response to acidic pH
CASZ2_RS03580	COG5650	phosphatidylinositol metabolic process
CASZ2_RS03585	COG0488	(ABC) transporter
CASZ2_RS03625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CASZ2_RS03640	COG0321	lipoyl(octanoyl) transferase activity
CASZ2_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
CASZ2_RS03650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CASZ2_RS03685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CASZ2_RS03690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CASZ2_RS03730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CASZ2_RS03735	COG0723	plastoquinol--plastocyanin reductase activity
CASZ2_RS03740	COG2010	Cytochrome c
CASZ2_RS03745	COG1845	cytochrome c oxidase, subunit III
CASZ2_RS03755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CASZ2_RS03770	COG0088	Forms part of the polypeptide exit tunnel
CASZ2_RS03775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CASZ2_RS03800	COG1940	carbohydrate kinase activity
CASZ2_RS03820	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CASZ2_RS03825	COG1234	tRNA 3'-trailer cleavage
CASZ2_RS03835	COG0515	serine threonine protein kinase
CASZ2_RS03835	COG2815	serine threonine protein kinase
CASZ2_RS03860	COG0210	DNA helicase
CASZ2_RS03895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CASZ2_RS03895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CASZ2_RS03900	COG0509	glycine decarboxylation via glycine cleavage system
CASZ2_RS03905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CASZ2_RS03925	COG0714	Associated with various cellular activities
CASZ2_RS03930	COG2001	Belongs to the MraZ family
CASZ2_RS03935	COG0275	rRNA processing
CASZ2_RS03945	COG0768	penicillin binding
CASZ2_RS03950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CASZ2_RS03955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CASZ2_RS03960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CASZ2_RS03965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CASZ2_RS03975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CASZ2_RS03980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CASZ2_RS04000	COG1799	cell septum assembly
CASZ2_RS04030	COG0469	pyruvate kinase activity
CASZ2_RS04035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CASZ2_RS04040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CASZ2_RS04070	COG0277	FAD linked oxidase domain protein
CASZ2_RS04080	COG0539	negative regulation of cytoplasmic translation
CASZ2_RS04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CASZ2_RS04100	COG1120	ATPase activity
CASZ2_RS04105	COG4988	ABC transporter
CASZ2_RS04110	COG1132	(ABC) transporter
CASZ2_RS04115	COG0237	dephospho-CoA kinase activity
CASZ2_RS04125	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CASZ2_RS04140	COG1429	ligase activity, forming nitrogen-metal bonds
CASZ2_RS04145	COG1120	ATPase activity
CASZ2_RS04150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CASZ2_RS04165	COG1136	(ABC) transporter
CASZ2_RS04165	COG0577	efflux transmembrane transporter activity
CASZ2_RS04170	COG1136	(ABC) transporter
CASZ2_RS04195	COG0556	nucleotide-excision repair
CASZ2_RS04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CASZ2_RS04235	COG0322	excinuclease ABC activity
CASZ2_RS04240	COG1660	Displays ATPase and GTPase activities
CASZ2_RS04245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CASZ2_RS04250	COG1481	regulation of sporulation
CASZ2_RS04255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CASZ2_RS04260	COG0126	phosphoglycerate kinase activity
CASZ2_RS04265	COG0149	triose-phosphate isomerase activity
CASZ2_RS04270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CASZ2_RS04280	COG0285	dihydrofolate synthase activity
CASZ2_RS04290	COG0105	UTP biosynthetic process
CASZ2_RS04305	COG1530	ribonuclease E activity
CASZ2_RS04310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CASZ2_RS04315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CASZ2_RS04325	COG1309	transcriptional regulator
CASZ2_RS04335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CASZ2_RS04340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CASZ2_RS04345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CASZ2_RS04350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CASZ2_RS04360	COG0406	alpha-ribazole phosphatase activity
CASZ2_RS04405	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CASZ2_RS04430	COG1309	transcriptional regulator
CASZ2_RS04450	COG1136	(ABC) transporter
CASZ2_RS04450	COG0577	efflux transmembrane transporter activity
CASZ2_RS04460	COG2197	response regulator
CASZ2_RS04525	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CASZ2_RS04530	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CASZ2_RS04550	COG2814	Major facilitator Superfamily
CASZ2_RS04560	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CASZ2_RS04565	COG0352	thiamine-phosphate diphosphorylase activity
CASZ2_RS04570	COG0039	L-malate dehydrogenase activity
CASZ2_RS04575	COG0281	malic enzyme
CASZ2_RS04600	COG0495	leucyl-tRNA aminoacylation
CASZ2_RS04605	COG1555	photosystem II stabilization
CASZ2_RS04605	COG1596	polysaccharide export
CASZ2_RS04625	COG0268	Binds directly to 16S ribosomal RNA
CASZ2_RS04635	COG0481	GTPase activity
CASZ2_RS04640	COG4948	Mandelate Racemase Muconate Lactonizing
CASZ2_RS04645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CASZ2_RS04650	COG1169	isochorismate synthase
CASZ2_RS04680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CASZ2_RS04685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CASZ2_RS04690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CASZ2_RS04715	COG0483	inositol monophosphate 1-phosphatase activity
CASZ2_RS04720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CASZ2_RS04725	COG1420	regulation of RNA biosynthetic process
CASZ2_RS04730	COG0484	heat shock protein binding
CASZ2_RS04740	COG1063	alcohol dehydrogenase
CASZ2_RS04745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CASZ2_RS04745	COG2213	PTS system mannitol-specific
CASZ2_RS04755	COG0514	ATP-dependent DNA helicase (RecQ)
CASZ2_RS04760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CASZ2_RS04770	COG0343	queuine tRNA-ribosyltransferase activity
CASZ2_RS04775	COG4585	Histidine kinase
CASZ2_RS04780	COG2197	response regulator
CASZ2_RS04785	COG4152	abc transporter atp-binding protein
CASZ2_RS04820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CASZ2_RS04830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CASZ2_RS04835	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CASZ2_RS04840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CASZ2_RS04845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CASZ2_RS04855	COG1381	Involved in DNA repair and RecF pathway recombination
CASZ2_RS04870	COG2197	response regulator
CASZ2_RS04880	COG0423	glycine-tRNA ligase activity
CASZ2_RS04890	COG1053	succinate dehydrogenase
CASZ2_RS04900	COG0778	Nitroreductase
CASZ2_RS04920	COG0358	DNA primase activity
CASZ2_RS04925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CASZ2_RS04940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CASZ2_RS04945	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CASZ2_RS04965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CASZ2_RS04970	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CASZ2_RS04975	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CASZ2_RS04980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CASZ2_RS04985	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CASZ2_RS05020	COG0561	phosphatase activity
CASZ2_RS05030	COG0714	Associated with various cellular activities
CASZ2_RS05065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CASZ2_RS05070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CASZ2_RS05080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CASZ2_RS05090	COG2814	Major facilitator Superfamily
CASZ2_RS05100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CASZ2_RS05120	COG1335	isochorismatase
CASZ2_RS05125	COG0667	Aldo Keto reductase
CASZ2_RS05130	COG0667	Aldo Keto reductase
CASZ2_RS05135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CASZ2_RS05140	COG0540	Belongs to the ATCase OTCase family
CASZ2_RS05145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CASZ2_RS05150	COG0505	Belongs to the CarA family
CASZ2_RS05155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CASZ2_RS05160	COG0543	2 iron, 2 sulfur cluster binding
CASZ2_RS05165	COG0167	dihydroorotate dehydrogenase activity
CASZ2_RS05170	COG0284	orotidine-5'-phosphate decarboxylase activity
CASZ2_RS05175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CASZ2_RS05185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CASZ2_RS05195	COG1546	Belongs to the CinA family
CASZ2_RS05195	COG1058	Belongs to the CinA family
CASZ2_RS05200	COG1396	sequence-specific DNA binding
CASZ2_RS05225	COG2137	regulation of response to DNA damage stimulus
CASZ2_RS05230	COG1418	mRNA catabolic process
CASZ2_RS05235	COG2017	converts alpha-aldose to the beta-anomer
CASZ2_RS05240	COG1288	antiporter activity
CASZ2_RS05245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CASZ2_RS05255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CASZ2_RS05260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CASZ2_RS05265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CASZ2_RS05275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CASZ2_RS05285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CASZ2_RS05290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CASZ2_RS05305	COG1643	Atp-dependent helicase
CASZ2_RS05310	COG1946	Acyl-CoA thioesterase
CASZ2_RS05315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CASZ2_RS05320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CASZ2_RS05330	COG1309	transcriptional regulator
CASZ2_RS05370	COG0187	DNA topoisomerase II activity
CASZ2_RS05375	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CASZ2_RS05385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CASZ2_RS05405	COG1435	thymidine kinase activity
CASZ2_RS05430	COG0756	dUTP diphosphatase activity
CASZ2_RS05450	COG0569	domain protein
CASZ2_RS05455	COG0531	amino acid
CASZ2_RS05460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CASZ2_RS05465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CASZ2_RS05470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CASZ2_RS05485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CASZ2_RS05495	COG2964	Protein conserved in bacteria
CASZ2_RS05505	COG1113	amino acid transport
CASZ2_RS05510	COG2326	polyphosphate kinase activity
CASZ2_RS05535	COG1064	alcohol dehydrogenase
CASZ2_RS05540	COG3850	Histidine kinase
CASZ2_RS05550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CASZ2_RS05560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CASZ2_RS05585	COG0509	glycine decarboxylation via glycine cleavage system
CASZ2_RS05590	COG1716	ATPase activity
CASZ2_RS05610	COG1295	ribonuclease BN
CASZ2_RS05620	COG0205	6-phosphofructokinase activity
CASZ2_RS05630	COG0009	L-threonylcarbamoyladenylate synthase
CASZ2_RS05645	COG1739	Uncharacterized protein family UPF0029
CASZ2_RS05655	COG0443	Heat shock 70 kDa protein
CASZ2_RS05695	COG0033	Phosphoglucomutase
CASZ2_RS05705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CASZ2_RS05725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CASZ2_RS05740	COG0366	Alpha amylase catalytic
CASZ2_RS05755	COG0482	sulfurtransferase activity
CASZ2_RS05780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CASZ2_RS05785	COG0154	amidase activity
CASZ2_RS05790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CASZ2_RS05800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CASZ2_RS05820	COG0134	indole-3-glycerol-phosphate synthase activity
CASZ2_RS05825	COG0133	tryptophan synthase activity
CASZ2_RS05835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CASZ2_RS05840	COG0070	glutamate synthase
CASZ2_RS05840	COG0069	glutamate synthase activity
CASZ2_RS05840	COG0067	glutamate synthase
CASZ2_RS05855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CASZ2_RS05865	COG1737	Transcriptional regulator
CASZ2_RS05870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CASZ2_RS05885	COG2971	BadF BadG BcrA BcrD
CASZ2_RS05895	COG2723	6-phospho-beta-galactosidase activity
CASZ2_RS05900	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CASZ2_RS05905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CASZ2_RS05910	COG1447	Phosphotransferase system cellobiose-specific component IIA
CASZ2_RS05930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CASZ2_RS05935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CASZ2_RS05940	COG0131	Imidazoleglycerol-phosphate dehydratase
CASZ2_RS05945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CASZ2_RS05950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CASZ2_RS05955	COG0217	transcriptional regulatory protein
CASZ2_RS05960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CASZ2_RS05965	COG0632	four-way junction helicase activity
CASZ2_RS05970	COG2255	four-way junction helicase activity
CASZ2_RS05980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CASZ2_RS05985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CASZ2_RS05990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CASZ2_RS06000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CASZ2_RS06005	COG1196	nuclear chromosome segregation
CASZ2_RS06010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CASZ2_RS06015	COG0124	histidyl-tRNA synthetase
CASZ2_RS06045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CASZ2_RS06060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CASZ2_RS06065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CASZ2_RS06070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CASZ2_RS06075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CASZ2_RS06080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CASZ2_RS06085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CASZ2_RS06090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CASZ2_RS06105	COG2326	polyphosphate kinase activity
CASZ2_RS06110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CASZ2_RS06115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CASZ2_RS06125	COG0194	GDP metabolic process
CASZ2_RS06130	COG1758	RNA polymerase activity
CASZ2_RS06140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CASZ2_RS06150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CASZ2_RS06170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CASZ2_RS06190	COG1511	domain protein
CASZ2_RS06195	COG1129	ABC transporter
CASZ2_RS06205	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CASZ2_RS06215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CASZ2_RS06220	COG1160	GTP binding
CASZ2_RS06240	COG0738	Major facilitator superfamily
CASZ2_RS06245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CASZ2_RS06260	COG0427	acetyl-CoA hydrolase
CASZ2_RS06275	COG1522	sequence-specific DNA binding
CASZ2_RS06285	COG1216	Glycosyl transferase, family 2
CASZ2_RS06300	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CASZ2_RS06315	COG1230	cation diffusion facilitator family transporter
CASZ2_RS06335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CASZ2_RS06340	COG2814	Major facilitator Superfamily
CASZ2_RS06345	COG1846	Transcriptional regulator
CASZ2_RS06370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CASZ2_RS06375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CASZ2_RS06380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CASZ2_RS06385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CASZ2_RS06390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CASZ2_RS06395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CASZ2_RS06400	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CASZ2_RS06405	COG0356	it plays a direct role in the translocation of protons across the membrane
CASZ2_RS06420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CASZ2_RS06430	COG2890	protein-(glutamine-N5) methyltransferase activity
CASZ2_RS06435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CASZ2_RS06440	COG0254	rRNA binding
CASZ2_RS06450	COG0083	homoserine kinase activity
CASZ2_RS06455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CASZ2_RS06460	COG0460	homoserine dehydrogenase
CASZ2_RS06480	COG0508	dehydrogenase complex catalyzes the overall conversion of
CASZ2_RS06480	COG0567	Dehydrogenase, E1 component
CASZ2_RS06510	COG1595	DNA-templated transcription, initiation
CASZ2_RS06520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CASZ2_RS06525	COG1162	GTPase activity
CASZ2_RS06535	COG0483	inositol monophosphate 1-phosphatase activity
CASZ2_RS06540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CASZ2_RS06550	COG0444	Belongs to the ABC transporter superfamily
CASZ2_RS06560	COG0601	transmembrane transport
CASZ2_RS06565	COG0747	negative chemotaxis
CASZ2_RS06660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CASZ2_RS06755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CASZ2_RS06780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CASZ2_RS06785	COG1074	ATP-dependent DNA helicase activity
CASZ2_RS06790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CASZ2_RS06830	COG1113	amino acid transport
CASZ2_RS06835	COG0180	Tryptophanyl-tRNA synthetase
CASZ2_RS06840	COG0613	PHP domain protein
CASZ2_RS06845	COG2902	Dehydrogenase
CASZ2_RS06865	COG0653	protein targeting
CASZ2_RS06870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CASZ2_RS06880	COG5401	PFAM Sporulation and spore germination
CASZ2_RS06885	COG5000	phosphorelay sensor kinase activity
CASZ2_RS06885	COG5002	protein histidine kinase activity
CASZ2_RS06890	COG0745	RESPONSE REGULATOR receiver
CASZ2_RS06895	COG1678	Uncharacterized ACR, COG1678
CASZ2_RS06975	COG0165	Argininosuccinate lyase
CASZ2_RS06980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CASZ2_RS06985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CASZ2_RS06995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CASZ2_RS07000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CASZ2_RS07005	COG2177	Part of the ABC transporter FtsEX involved in
CASZ2_RS07010	COG2884	Cell division ATP-binding protein ftsE
CASZ2_RS07015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CASZ2_RS07030	COG1674	ftsk spoiiie
CASZ2_RS07050	COG1181	Belongs to the D-alanine--D-alanine ligase family
CASZ2_RS07060	COG0066	3-isopropylmalate dehydratase activity
CASZ2_RS07065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CASZ2_RS07070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CASZ2_RS07075	COG1414	Transcriptional regulator
CASZ2_RS07090	COG1266	CAAX protease self-immunity
CASZ2_RS07105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CASZ2_RS07110	COG0473	3-isopropylmalate dehydrogenase activity
CASZ2_RS07115	COG0473	3-isopropylmalate dehydrogenase activity
CASZ2_RS07125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CASZ2_RS07140	COG0537	adenosine 5'-monophosphoramidase activity
CASZ2_RS07145	COG0107	imidazoleglycerol-phosphate synthase activity
CASZ2_RS07150	COG4581	dead DEAH box helicase
CASZ2_RS07160	COG0805	protein transport
CASZ2_RS07165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CASZ2_RS07185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CASZ2_RS07190	COG0545	Peptidyl-prolyl cis-trans isomerase
CASZ2_RS07215	COG4974	Belongs to the 'phage' integrase family
CASZ2_RS07220	COG0494	nUDIX hydrolase
CASZ2_RS07225	COG0504	CTP synthase activity
CASZ2_RS07245	COG0497	DNA recombination
CASZ2_RS07250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CASZ2_RS07260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CASZ2_RS07265	COG1122	ATPase activity
CASZ2_RS07270	COG1268	BioY protein
CASZ2_RS07275	COG0647	UMP catabolic process
CASZ2_RS07300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CASZ2_RS07315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CASZ2_RS07320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CASZ2_RS07320	COG0072	phenylalanine-tRNA ligase activity
CASZ2_RS07325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CASZ2_RS07335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CASZ2_RS07340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CASZ2_RS07345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CASZ2_RS07360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CASZ2_RS07365	COG0140	phosphoribosyl-ATP diphosphatase activity
CASZ2_RS07370	COG3201	nicotinamide mononucleotide transporter
CASZ2_RS07385	COG0667	Aldo Keto reductase
CASZ2_RS07390	COG0372	Belongs to the citrate synthase family
CASZ2_RS07395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CASZ2_RS07420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CASZ2_RS07435	COG0792	nuclease activity
CASZ2_RS07445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CASZ2_RS07450	COG0681	Belongs to the peptidase S26 family
CASZ2_RS07455	COG0335	large ribosomal subunit rRNA binding
CASZ2_RS07465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CASZ2_RS07470	COG1053	succinate dehydrogenase
CASZ2_RS07480	COG0336	Belongs to the RNA methyltransferase TrmD family
CASZ2_RS07485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CASZ2_RS07490	COG1837	Belongs to the UPF0109 family
CASZ2_RS07495	COG0228	four-way junction DNA binding
CASZ2_RS07545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CASZ2_RS07550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CASZ2_RS07555	COG0571	ribonuclease III activity
CASZ2_RS07560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CASZ2_RS07580	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS07585	COG1609	Transcriptional regulator
CASZ2_RS07615	COG0601	transmembrane transport
CASZ2_RS07635	COG4166	transmembrane transport
CASZ2_RS07650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CASZ2_RS07670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CASZ2_RS07675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CASZ2_RS07685	COG0028	Belongs to the TPP enzyme family
CASZ2_RS07695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CASZ2_RS07700	COG1185	polyribonucleotide nucleotidyltransferase activity
CASZ2_RS07705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CASZ2_RS07725	COG0517	IMP dehydrogenase activity
CASZ2_RS07725	COG4175	Glycine betaine
CASZ2_RS07730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CASZ2_RS07760	COG3732	PTS system glucitol sorbitol-specific
CASZ2_RS07775	COG0371	Dehydrogenase
CASZ2_RS07780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CASZ2_RS07795	COG1131	(ABC) transporter
CASZ2_RS07800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CASZ2_RS07810	COG0195	Participates in both transcription termination and antitermination
CASZ2_RS07815	COG0779	Required for maturation of 30S ribosomal subunits
CASZ2_RS07825	COG0730	response to heat
CASZ2_RS07835	COG0442	prolyl-tRNA aminoacylation
CASZ2_RS07845	COG0803	Belongs to the bacterial solute-binding protein 9 family
CASZ2_RS07845	COG0803	Belongs to the bacterial solute-binding protein 9 family
CASZ2_RS07855	COG1121	(ABC) transporter
CASZ2_RS07860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CASZ2_RS07870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CASZ2_RS07885	COG0750	zinc metalloprotease
CASZ2_RS07890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CASZ2_RS07905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CASZ2_RS07910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CASZ2_RS07915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CASZ2_RS07925	COG0575	Belongs to the CDS family
CASZ2_RS07930	COG0233	cytoplasmic translational termination
CASZ2_RS07935	COG0528	UMP kinase activity
CASZ2_RS07940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CASZ2_RS07945	COG0052	Belongs to the universal ribosomal protein uS2 family
CASZ2_RS07950	COG4974	Belongs to the 'phage' integrase family
CASZ2_RS07965	COG0242	peptide deformylase activity
CASZ2_RS07990	COG1119	ATPase activity
CASZ2_RS08000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CASZ2_RS08020	COG2226	methyltransferase
CASZ2_RS08030	COG0488	(ABC) transporter
CASZ2_RS08060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CASZ2_RS08065	COG0396	ATPase activity
CASZ2_RS08080	COG0719	Fe-S assembly protein
CASZ2_RS08100	COG1175	transmembrane transport
CASZ2_RS08115	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CASZ2_RS08120	COG1131	(ABC) transporter
CASZ2_RS08140	COG0109	protoheme IX farnesyltransferase activity
CASZ2_RS08160	COG0363	glucosamine-6-phosphate deaminase activity
CASZ2_RS08175	COG0525	valine-tRNA ligase activity
CASZ2_RS08180	COG1470	cell adhesion involved in biofilm formation
CASZ2_RS08180	COG0366	Alpha amylase catalytic
CASZ2_RS08185	COG0793	Belongs to the peptidase S41A family
CASZ2_RS08185	COG4946	Tricorn protease homolog
CASZ2_RS08190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CASZ2_RS08195	COG0740	serine-type endopeptidase activity
CASZ2_RS08200	COG0740	serine-type endopeptidase activity
CASZ2_RS08210	COG0544	peptidyl-prolyl cis-trans isomerase activity
CASZ2_RS08240	COG1201	RNA secondary structure unwinding
CASZ2_RS08270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CASZ2_RS08270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CASZ2_RS08290	COG0698	ribose 5-phosphate isomerase
CASZ2_RS08295	COG4552	Acetyltransferase involved in intracellular survival and related
CASZ2_RS08300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CASZ2_RS08320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CASZ2_RS08355	COG1695	Transcriptional regulator
CASZ2_RS08370	COG0629	single-stranded DNA binding
CASZ2_RS08400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CASZ2_RS08410	COG1113	amino acid transport
CASZ2_RS08415	COG0515	serine threonine protein kinase
CASZ2_RS08420	COG1472	Belongs to the glycosyl hydrolase 3 family
CASZ2_RS08450	COG0587	DNA-directed DNA polymerase activity
CASZ2_RS08470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CASZ2_RS08485	COG1653	transport
CASZ2_RS08570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CASZ2_RS08580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CASZ2_RS08585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CASZ2_RS08590	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CASZ2_RS08595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CASZ2_RS08620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CASZ2_RS08650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CASZ2_RS08655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CASZ2_RS08665	COG2835	tetraacyldisaccharide 4'-kinase activity
CASZ2_RS08700	COG0662	Cupin 2, conserved barrel domain protein
CASZ2_RS08700	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CASZ2_RS08720	COG1316	TRANSCRIPTIONal
CASZ2_RS08745	COG3340	Belongs to the peptidase S51 family
CASZ2_RS08760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CASZ2_RS08770	COG0424	maF-like protein
CASZ2_RS08785	COG4221	oxidoreductase activity
CASZ2_RS08790	COG0351	phosphomethylpyrimidine kinase
CASZ2_RS08815	COG0598	Magnesium transport protein CorA
CASZ2_RS08830	COG4770	biotin carboxylase activity
CASZ2_RS08850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CASZ2_RS08855	COG0318	PFAM AMP-dependent synthetase and ligase
CASZ2_RS08875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CASZ2_RS08880	COG0328	RNA-DNA hybrid ribonuclease activity
CASZ2_RS08905	COG1744	ABC transporter substrate-binding protein PnrA-like
CASZ2_RS08915	COG1253	flavin adenine dinucleotide binding
CASZ2_RS08940	COG0039	L-malate dehydrogenase activity
CASZ2_RS08945	COG1012	belongs to the aldehyde dehydrogenase family
CASZ2_RS08955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CASZ2_RS08980	COG0138	bifunctional purine biosynthesis protein purh
CASZ2_RS08990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CASZ2_RS08995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CASZ2_RS08995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CASZ2_RS09005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CASZ2_RS09005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CASZ2_RS09020	COG0045	succinate-CoA ligase (ADP-forming) activity
CASZ2_RS09040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CASZ2_RS09045	COG2011	ABC-type metal ion transport system permease component
CASZ2_RS09065	COG0519	Catalyzes the synthesis of GMP from XMP
CASZ2_RS09065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CASZ2_RS09075	COG1045	serine acetyltransferase
CASZ2_RS09080	COG1605	Chorismate mutase
CASZ2_RS09080	COG0287	Prephenate dehydrogenase
CASZ2_RS09085	COG0516	GMP reductase activity
CASZ2_RS09105	COG1115	amino acid carrier protein
CASZ2_RS09115	COG0459	protein refolding
CASZ2_RS09120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CASZ2_RS09145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CASZ2_RS09150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CASZ2_RS09165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CASZ2_RS09170	COG0456	acetyltransferase
CASZ2_RS09175	COG1214	PFAM Peptidase M22, glycoprotease
CASZ2_RS09175	COG0456	acetyltransferase
CASZ2_RS09180	COG0802	atpase or kinase
CASZ2_RS09190	COG0513	Belongs to the DEAD box helicase family
CASZ2_RS09205	COG1136	(ABC) transporter
CASZ2_RS09210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CASZ2_RS09210	COG0438	transferase activity, transferring glycosyl groups
CASZ2_RS09220	COG0736	holo-[acyl-carrier-protein] synthase activity
CASZ2_RS09225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CASZ2_RS09240	COG1072	(Pantothenic acid kinase))
CASZ2_RS09255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CASZ2_RS09260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CASZ2_RS09265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CASZ2_RS09285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CASZ2_RS09290	COG0101	tRNA pseudouridine synthase activity
CASZ2_RS09305	COG3845	ABC transporter
CASZ2_RS09315	COG1028	Short-chain dehydrogenase reductase Sdr
CASZ2_RS09350	COG2271	Major facilitator Superfamily
CASZ2_RS09360	COG0438	transferase activity, transferring glycosyl groups
CASZ2_RS09365	COG0203	ribosomal protein L17
CASZ2_RS09370	COG0202	RNA polymerase activity
CASZ2_RS09375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CASZ2_RS09380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CASZ2_RS09385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CASZ2_RS09390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CASZ2_RS09395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CASZ2_RS09405	COG0563	adenylate kinase activity
CASZ2_RS09425	COG0584	glycerophosphoryl diester phosphodiesterase
CASZ2_RS09445	COG0200	Binds to the 23S rRNA
CASZ2_RS09450	COG1841	ribosomal large subunit assembly
CASZ2_RS09455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CASZ2_RS09460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CASZ2_RS09465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CASZ2_RS09470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CASZ2_RS09475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CASZ2_RS09480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CASZ2_RS09485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CASZ2_RS09490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CASZ2_RS09495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CASZ2_RS09500	COG0255	Belongs to the universal ribosomal protein uL29 family
CASZ2_RS09505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CASZ2_RS09510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CASZ2_RS09515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CASZ2_RS09520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CASZ2_RS09525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CASZ2_RS09530	COG0089	rRNA binding
CASZ2_RS09535	COG0088	Forms part of the polypeptide exit tunnel
CASZ2_RS09540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CASZ2_RS09545	COG0051	transcription antitermination factor activity, RNA binding
CASZ2_RS09550	COG0156	8-amino-7-oxononanoate synthase activity
CASZ2_RS09565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CASZ2_RS09570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CASZ2_RS09575	COG0737	Belongs to the 5'-nucleotidase family
CASZ2_RS09585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CASZ2_RS09600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CASZ2_RS09605	COG0049	tRNA binding
CASZ2_RS09610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CASZ2_RS09630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CASZ2_RS09635	COG0085	RNA polymerase activity
CASZ2_RS09640	COG0222	ribosome binding
CASZ2_RS09645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CASZ2_RS09650	COG0081	regulation of translation
CASZ2_RS09655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CASZ2_RS09660	COG0250	Participates in transcription elongation, termination and antitermination
CASZ2_RS09665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CASZ2_RS09675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CASZ2_RS09680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CASZ2_RS09690	COG2030	dehydratase
CASZ2_RS09695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CASZ2_RS09715	COG0708	Exodeoxyribonuclease III
CASZ2_RS09720	COG1024	Enoyl-CoA hydratase
CASZ2_RS09730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CASZ2_RS09735	COG0649	NAD binding
CASZ2_RS09740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CASZ2_RS09745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CASZ2_RS09745	COG0674	pyruvate-flavodoxin oxidoreductase activity
CASZ2_RS09750	COG1013	pyruvate-flavodoxin oxidoreductase activity
CASZ2_RS09775	COG3590	peptidase
CASZ2_RS09785	COG1126	abc transporter atp-binding protein
CASZ2_RS09800	COG1131	(ABC) transporter
CASZ2_RS09820	COG2301	Belongs to the HpcH HpaI aldolase family
CASZ2_RS09840	COG1007	ATP synthesis coupled electron transport
CASZ2_RS09855	COG0713	ATP synthesis coupled electron transport
CASZ2_RS09865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CASZ2_RS09870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CASZ2_RS09875	COG1034	ATP synthesis coupled electron transport
CASZ2_RS09880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CASZ2_RS09890	COG0649	NAD binding
CASZ2_RS09895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CASZ2_RS09900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CASZ2_RS09910	COG0644	oxidoreductase
CASZ2_RS09935	COG2226	methyltransferase
CASZ2_RS09945	COG1132	(ABC) transporter
CASZ2_RS09955	COG1136	(ABC) transporter
CASZ2_RS09975	COG2376	Dihydroxyacetone kinase
CASZ2_RS09980	COG1461	Dihydroxyacetone kinase
CASZ2_RS09985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CASZ2_RS09985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CASZ2_RS09985	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CASZ2_RS09995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CASZ2_RS10005	COG0039	L-malate dehydrogenase activity
CASZ2_RS10035	COG1175	transmembrane transport
CASZ2_RS10040	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS10075	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS10080	COG1175	transmembrane transport
CASZ2_RS10100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CASZ2_RS10115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CASZ2_RS10140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CASZ2_RS10165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CASZ2_RS10190	COG0047	phosphoribosylformylglycinamidine synthase activity
CASZ2_RS10195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CASZ2_RS10215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CASZ2_RS10220	COG0151	Belongs to the GarS family
CASZ2_RS10225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CASZ2_RS10235	COG2188	Transcriptional regulator
CASZ2_RS10240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CASZ2_RS10245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CASZ2_RS10295	COG0840	transmembrane signaling receptor activity
CASZ2_RS10305	COG0191	fructose-bisphosphate aldolase activity
CASZ2_RS10320	COG0586	Pfam SNARE associated Golgi protein
CASZ2_RS10340	COG3012	SEC-C Motif Domain Protein
CASZ2_RS10345	COG0477	Major facilitator Superfamily
CASZ2_RS10350	COG0542	response to heat
CASZ2_RS10365	COG3588	fructose-bisphosphate aldolase
CASZ2_RS10380	COG4585	Histidine kinase
CASZ2_RS10385	COG2197	response regulator
CASZ2_RS10390	COG1136	(ABC) transporter
CASZ2_RS10390	COG4591	ABC-type transport system involved in lipoprotein release permease component
CASZ2_RS10395	COG0577	efflux transmembrane transporter activity
CASZ2_RS10395	COG1136	(ABC) transporter
CASZ2_RS10400	COG1051	belongs to the nudix hydrolase family
CASZ2_RS10405	COG1113	amino acid transport
CASZ2_RS10410	COG0569	domain protein
CASZ2_RS10410	COG2985	domain, Protein
CASZ2_RS10415	COG1063	alcohol dehydrogenase
CASZ2_RS10425	COG0789	Transcriptional regulator
CASZ2_RS10430	COG0484	heat shock protein binding
CASZ2_RS10435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CASZ2_RS10455	COG0745	RESPONSE REGULATOR receiver
CASZ2_RS10465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CASZ2_RS10480	COG0574	Belongs to the PEP-utilizing enzyme family
CASZ2_RS10480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CASZ2_RS10485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CASZ2_RS10495	COG0560	Phosphoserine phosphatase
CASZ2_RS10495	COG3830	Belongs to the UPF0237 family
CASZ2_RS10500	COG0676	glucose-6-phosphate 1-epimerase activity
CASZ2_RS10510	COG0154	amidase activity
CASZ2_RS10550	COG0662	Cupin 2, conserved barrel domain protein
CASZ2_RS10595	COG1131	(ABC) transporter
CASZ2_RS10605	COG0508	dehydrogenase complex catalyzes the overall conversion of
CASZ2_RS10610	COG0022	dehydrogenase e1 component
CASZ2_RS10645	COG1132	(ABC) transporter
CASZ2_RS10665	COG2378	regulation of single-species biofilm formation
CASZ2_RS10715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CASZ2_RS10730	COG2205	protein histidine kinase activity
CASZ2_RS10745	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CASZ2_RS10760	COG1902	pentaerythritol trinitrate reductase activity
CASZ2_RS10770	COG0477	Major facilitator Superfamily
CASZ2_RS10775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CASZ2_RS10775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CASZ2_RS10780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CASZ2_RS10805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CASZ2_RS10810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CASZ2_RS10820	COG0018	arginyl-trna synthetase
CASZ2_RS10825	COG0656	L-ascorbic acid biosynthetic process
CASZ2_RS10835	COG0166	Belongs to the GPI family
CASZ2_RS10850	COG0783	Belongs to the Dps family
CASZ2_RS10855	COG4581	dead DEAH box helicase
CASZ2_RS10860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CASZ2_RS10915	COG0701	Predicted permease
CASZ2_RS10940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CASZ2_RS10945	COG1408	metallophosphoesterase
CASZ2_RS10955	COG0693	protein deglycase activity
CASZ2_RS10960	COG0747	negative chemotaxis
CASZ2_RS10970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CASZ2_RS10980	COG4608	Belongs to the ABC transporter superfamily
CASZ2_RS10985	COG0254	rRNA binding
CASZ2_RS10990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CASZ2_RS10995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CASZ2_RS11000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CASZ2_RS11015	COG1472	Belongs to the glycosyl hydrolase 3 family
CASZ2_RS11020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CASZ2_RS11025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CASZ2_RS11035	COG1228	amidohydrolase
CASZ2_RS11040	COG2986	histidine ammonia-lyase
CASZ2_RS11070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CASZ2_RS11090	COG3263	regulation of cellular component size
CASZ2_RS11120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CASZ2_RS11140	COG3158	transport of potassium into the cell
CASZ2_RS11145	COG0505	Belongs to the CarA family
CASZ2_RS11170	COG1609	Transcriptional regulator
CASZ2_RS11175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CASZ2_RS11215	COG0137	argininosuccinate synthase activity
CASZ2_RS11240	COG0561	phosphatase activity
CASZ2_RS11280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CASZ2_RS11290	COG0644	oxidoreductase
CASZ2_RS11325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CASZ2_RS11340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CASZ2_RS11360	COG1968	undecaprenyl-diphosphatase activity
CASZ2_RS11365	COG1528	Iron-storage protein
CASZ2_RS11380	COG0359	binds to the 23S rRNA
CASZ2_RS11385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CASZ2_RS11395	COG0360	Binds together with S18 to 16S ribosomal RNA
CASZ2_RS11410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS11410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CASZ2_RS11410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS11415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS11415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CASZ2_RS11415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CASZ2_RS11425	COG1022	Amp-dependent synthetase and ligase
CASZ2_RS11430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CASZ2_RS11450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CASZ2_RS11460	COG2608	mercury ion transmembrane transporter activity
CASZ2_RS11465	COG1937	Protein conserved in bacteria
CASZ2_RS11470	COG0305	Participates in initiation and elongation during chromosome replication
CASZ2_RS11475	COG0604	alcohol dehydrogenase
CASZ2_RS11475	COG1028	Short-chain dehydrogenase reductase Sdr
CASZ2_RS11475	COG3321	synthase
CASZ2_RS11500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CASZ2_RS11505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CASZ2_RS11520	COG1113	amino acid transport
CASZ2_RS11540	COG0534	Mate efflux family protein
CASZ2_RS11580	COG0205	6-phosphofructokinase activity
CASZ2_RS11590	COG1113	amino acid transport
CASZ2_RS11615	COG1376	ErfK ybiS ycfS ynhG family protein
CASZ2_RS11620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CASZ2_RS11630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CASZ2_RS11640	COG1113	amino acid transport
CASZ2_RS11665	COG1376	ErfK ybiS ycfS ynhG family protein
CASZ2_RS11670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CASZ2_RS11680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CASZ2_RS11685	COG0686	Belongs to the AlaDH PNT family
CASZ2_RS11720	COG5012	cobalamin binding
CASZ2_RS11730	COG3457	Alanine racemase
CASZ2_RS11735	COG1113	amino acid transport
CASZ2_RS11740	COG1113	amino acid transport
CASZ2_RS11745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CASZ2_RS11750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CASZ2_RS11755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CASZ2_RS11780	COG0114	fumarate hydratase activity
CASZ2_RS11785	COG0395	ABC-type sugar transport system, permease component
CASZ2_RS11790	COG1175	transmembrane transport
CASZ2_RS11810	COG0668	transmembrane transport
CASZ2_RS11815	COG1929	Belongs to the glycerate kinase type-1 family
CASZ2_RS11825	COG0617	tRNA 3'-terminal CCA addition
CASZ2_RS11840	COG0515	serine threonine protein kinase
CASZ2_RS11845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CASZ2_RS11850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CASZ2_RS11870	COG1609	Transcriptional regulator
CASZ2_RS11905	COG3118	belongs to the thioredoxin family
CASZ2_RS11910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CASZ2_RS11940	COG0371	Dehydrogenase
CASZ2_RS11960	COG0698	ribose 5-phosphate isomerase
CASZ2_RS11970	COG1349	DNA-binding transcription factor activity
CASZ2_RS11975	COG1312	Catalyzes the dehydration of D-mannonate
CASZ2_RS11980	COG0246	Mannitol dehydrogenase
CASZ2_RS11985	COG1904	glucuronate isomerase
CASZ2_RS11990	COG1609	Transcriptional regulator
CASZ2_RS11995	COG2211	Major facilitator Superfamily
CASZ2_RS12005	COG3250	beta-galactosidase activity
CASZ2_RS12025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CASZ2_RS12030	COG1181	Belongs to the D-alanine--D-alanine ligase family
CASZ2_RS12040	COG2814	Major facilitator Superfamily
CASZ2_RS12045	COG1475	DNA binding
CASZ2_RS12075	COG0357	Ribosomal RNA small subunit methyltransferase G
CASZ2_RS12115	COG0706	membrane insertase activity
CASZ2_RS12120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CASZ2_RS12125	COG0594	ribonuclease P activity
CASZ2_RS12130	COG0230	Belongs to the bacterial ribosomal protein bL34 family