locus-tag	class	description
CYME_CMA007C	COG1045	serine acetyltransferase
CYME_CMA009C	COG1063	alcohol dehydrogenase
CYME_CMA021C	COG0484	heat shock protein binding
CYME_CMA040C	COG0372	Belongs to the citrate synthase family
CYME_CMA041C	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYME_CMA042C	COG0183	Belongs to the thiolase family
CYME_CMA044C	COG0415	Belongs to the DNA photolyase family
CYME_CMA048C	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYME_CMA056C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMA061C	COG0326	Molecular chaperone. Has ATPase activity
CYME_CMA065C	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYME_CMA067C	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYME_CMA072C	COG4581	dead DEAH box helicase
CYME_CMA077C	COG0436	Aminotransferase
CYME_CMA082C	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYME_CMA093C	COG0514	ATP-dependent DNA helicase (RecQ)
CYME_CMA098C	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CYME_CMA099C	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYME_CMA103C	COG2815	serine threonine protein kinase
CYME_CMA103C	COG0515	serine threonine protein kinase
CYME_CMA106C	COG1501	Belongs to the glycosyl hydrolase 31 family
CYME_CMA107C	COG0006	proline dipeptidase activity
CYME_CMA111C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMA124C	COG0484	heat shock protein binding
CYME_CMA140C	COG0557	exoribonuclease II activity
CYME_CMB003C	COG1160	GTP binding
CYME_CMB004C	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYME_CMB010C	COG0180	Tryptophanyl-tRNA synthetase
CYME_CMB013C	COG0187	DNA topoisomerase II activity
CYME_CMB021C	COG0459	protein refolding
CYME_CMB025C	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CYME_CMB031C	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYME_CMB032C	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYME_CMB040C	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYME_CMB043C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMB044C	COG0459	protein refolding
CYME_CMB055C	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYME_CMB055C	COG1587	Uroporphyrinogen-III synthase
CYME_CMB059C	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CYME_CMB062C	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CYME_CMB076C	COG1490	D-aminoacyl-tRNA deacylase activity
CYME_CMB083C	COG0459	protein refolding
CYME_CMB088C	COG0424	maF-like protein
CYME_CMB091C	COG2895	sulfate adenylyltransferase (ATP) activity
CYME_CMB092C	COG0445	tRNA wobble uridine modification
CYME_CMB093C	COG1429	ligase activity, forming nitrogen-metal bonds
CYME_CMB105C	COG0484	heat shock protein binding
CYME_CMB126C	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYME_CMB127C	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYME_CMB127C	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CYME_CMB139C	COG0681	Belongs to the peptidase S26 family
CYME_CMB142C	COG0750	zinc metalloprotease
CYME_CMB143C	COG0303	'Molybdopterin
CYME_CMB146C	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYME_CMB151C	COG0529	Catalyzes the synthesis of activated sulfate
CYME_CMB157C	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYME_CMB158C	COG0366	Alpha amylase catalytic
CYME_CMC011C	COG4178	(ABC) transporter
CYME_CMC024C	COG0564	pseudouridine synthase activity
CYME_CMC027C	COG0167	dihydroorotate dehydrogenase activity
CYME_CMC034C	COG0436	Aminotransferase
CYME_CMC037C	COG0423	glycine-tRNA ligase activity
CYME_CMC039C	COG0450	alkyl hydroperoxide reductase
CYME_CMC059C	COG1160	GTP binding
CYME_CMC066C	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYME_CMC076C	COG0543	2 iron, 2 sulfur cluster binding
CYME_CMC096C	COG0006	proline dipeptidase activity
CYME_CMC098C	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYME_CMC111C	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYME_CMC121C	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYME_CMC125C	COG0542	response to heat
CYME_CMC127C	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CYME_CMC132C	COG0200	Binds to the 23S rRNA
CYME_CMC136C	COG0489	protein tyrosine kinase activity
CYME_CMC137C	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYME_CMC141C	COG0537	adenosine 5'-monophosphoramidase activity
CYME_CMC145C	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYME_CMC147C	COG0529	Catalyzes the synthesis of activated sulfate
CYME_CMC147C	COG2895	sulfate adenylyltransferase (ATP) activity
CYME_CMC149C	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYME_CMC160C	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYME_CMC171C	COG1643	Atp-dependent helicase
CYME_CMD006C	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYME_CMD007C	COG1394	ATPase activity, coupled to movement of substances
CYME_CMD011C	COG2226	methyltransferase
CYME_CMD015C	COG0515	serine threonine protein kinase
CYME_CMD015C	COG2815	serine threonine protein kinase
CYME_CMD017C	COG0670	Belongs to the BI1 family
CYME_CMD021C	COG0481	GTPase activity
CYME_CMD031C	COG2264	protein methyltransferase activity
CYME_CMD049C	COG1078	dGTPase activity
CYME_CMD071C	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CYME_CMD076C	COG0194	GDP metabolic process
CYME_CMD077C	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYME_CMD077C	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYME_CMD081C	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYME_CMD083C	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYME_CMD084C	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYME_CMD090C	COG0602	queuosine metabolic process
CYME_CMD099C	COG0673	inositol 2-dehydrogenase activity
CYME_CMD104C	COG0113	porphobilinogen synthase activity
CYME_CMD113C	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYME_CMD121C	COG0415	Belongs to the DNA photolyase family
CYME_CMD123C	COG0514	ATP-dependent DNA helicase (RecQ)
CYME_CMD127C	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CYME_CMD133C	COG1132	(ABC) transporter
CYME_CMD134C	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CYME_CMD139C	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYME_CMD148C	COG1132	(ABC) transporter
CYME_CMD170C	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CYME_CMD171C	COG0402	S-adenosylhomocysteine deaminase activity
CYME_CMD184C	COG0058	SHG alpha-glucan phosphorylase activity
CYME_CME010C	COG2226	methyltransferase
CYME_CME015C	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYME_CME016C	COG0552	protein localization to endoplasmic reticulum
CYME_CME029C	COG1196	nuclear chromosome segregation
CYME_CME037C	COG0215	cysteine-tRNA ligase activity
CYME_CME047C	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYME_CME055C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CME061C	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYME_CME062C	COG0531	amino acid
CYME_CME064C	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYME_CME079C	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYME_CME090C	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYME_CME091C	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYME_CME095C	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYME_CME101C	COG0085	RNA polymerase activity
CYME_CME113C	COG0463	Glycosyl transferase, family 2
CYME_CME117C	COG4178	(ABC) transporter
CYME_CME119C	COG0515	serine threonine protein kinase
CYME_CME119C	COG2815	serine threonine protein kinase
CYME_CME132C	COG0181	hydroxymethylbilane synthase activity
CYME_CME136C	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYME_CME141C	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CYME_CME143C	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYME_CME145C	COG3588	fructose-bisphosphate aldolase
CYME_CME146C	COG2815	serine threonine protein kinase
CYME_CME146C	COG0515	serine threonine protein kinase
CYME_CME148C	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYME_CME151C	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CYME_CME165C	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYME_CME166C	COG1643	Atp-dependent helicase
CYME_CME172C	COG0515	serine threonine protein kinase
CYME_CME172C	COG2815	serine threonine protein kinase
CYME_CME179C	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYME_CME181C	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYME_CME186C	COG1022	Amp-dependent synthetase and ligase
CYME_CME186C	COG3320	Male sterility
CYME_CME188C	COG0012	GTP binding
CYME_CME190C	COG0335	large ribosomal subunit rRNA binding
CYME_CME194C	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYME_CME198C	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYME_CMF018C	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYME_CMF020C	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYME_CMF022C	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYME_CMF033C	COG0513	Belongs to the DEAD box helicase family
CYME_CMF047C	COG2897	thiosulfate sulfurtransferase activity
CYME_CMF051C	COG2815	serine threonine protein kinase
CYME_CMF051C	COG0515	serine threonine protein kinase
CYME_CMF055C	COG0302	gtp cyclohydrolase
CYME_CMF066C	COG0445	tRNA wobble uridine modification
CYME_CMF068C	COG0567	Dehydrogenase, E1 component
CYME_CMF073C	COG3158	transport of potassium into the cell
CYME_CMF076C	COG0484	heat shock protein binding
CYME_CMF078C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMF086C	COG0673	inositol 2-dehydrogenase activity
CYME_CMF089C	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYME_CMF097C	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CYME_CMF098C	COG0509	glycine decarboxylation via glycine cleavage system
CYME_CMF101C	COG2706	6-phosphogluconolactonase activity
CYME_CMF114C	COG0515	serine threonine protein kinase
CYME_CMF116C	COG3217	Mosc domain protein beta barrel domain protein
CYME_CMF116C	COG0633	Ferredoxin
CYME_CMF117C	COG0572	uridine kinase
CYME_CMF121C	COG1501	Belongs to the glycosyl hydrolase 31 family
CYME_CMF128C	COG3844	kynureninase activity
CYME_CMF139C	COG0515	serine threonine protein kinase
CYME_CMF139C	COG2815	serine threonine protein kinase
CYME_CMF152C	COG0662	Cupin 2, conserved barrel domain protein
CYME_CMF156C	COG0626	cystathionine gamma-synthase activity
CYME_CMF159C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMF178C	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYME_CMF179C	COG1465	3-dehydroquinate synthase
CYME_CMF182C	COG0308	aminopeptidase N
CYME_CMG004C	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYME_CMG009C	COG0357	Ribosomal RNA small subunit methyltransferase G
CYME_CMG021C	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYME_CMG023C	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYME_CMG039C	COG1362	aminopeptidase activity
CYME_CMG044C	COG1643	Atp-dependent helicase
CYME_CMG051C	COG0438	transferase activity, transferring glycosyl groups
CYME_CMG056C	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYME_CMG057C	COG0051	transcription antitermination factor activity, RNA binding
CYME_CMG058C	COG2119	membrane
CYME_CMG062C	COG0228	four-way junction DNA binding
CYME_CMG064C	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CYME_CMG066C	COG0436	Aminotransferase
CYME_CMG075C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMG094C	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CYME_CMG095C	COG0720	synthase
CYME_CMG108C	COG2815	serine threonine protein kinase
CYME_CMG108C	COG0515	serine threonine protein kinase
CYME_CMG109C	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYME_CMG111C	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYME_CMG124C	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYME_CMG132C	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYME_CMG133C	COG0556	nucleotide-excision repair
CYME_CMG146C	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYME_CMG148C	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYME_CMG156C	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CYME_CMG161C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMG179C	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYME_CMG189C	COG1196	nuclear chromosome segregation
CYME_CMG195C	COG0237	dephospho-CoA kinase activity
CYME_CMG196C	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYME_CMG198C	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYME_CMG200C	COG1012	belongs to the aldehyde dehydrogenase family
CYME_CMG211C	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYME_CMH008C	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYME_CMH009C	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CYME_CMH014C	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYME_CMH020C	COG1234	tRNA 3'-trailer cleavage
CYME_CMH021C	COG0393	Putative heavy-metal-binding
CYME_CMH022C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMH024C	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYME_CMH040C	COG0519	Catalyzes the synthesis of GMP from XMP
CYME_CMH040C	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYME_CMH046C	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYME_CMH052C	COG0205	6-phosphofructokinase activity
CYME_CMH066C	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYME_CMH069C	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYME_CMH083C	COG1051	belongs to the nudix hydrolase family
CYME_CMH083C	COG1056	cytidyltransferase-related domain
CYME_CMH090C	COG0215	cysteine-tRNA ligase activity
CYME_CMH095C	COG0483	inositol monophosphate 1-phosphatase activity
CYME_CMH100C	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CYME_CMH103C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMH107C	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CYME_CMH114C	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYME_CMH115C	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYME_CMH116C	COG2313	pseudouridylate synthase activity
CYME_CMH121C	COG0626	cystathionine gamma-synthase activity
CYME_CMH128C	COG2815	serine threonine protein kinase
CYME_CMH128C	COG0515	serine threonine protein kinase
CYME_CMH132C	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CYME_CMH137C	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYME_CMH138C	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYME_CMH138C	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYME_CMH139C	COG2921	Belongs to the UPF0250 family
CYME_CMH144C	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYME_CMH146C	COG1185	polyribonucleotide nucleotidyltransferase activity
CYME_CMH153C	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYME_CMH154C	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CYME_CMH166C	COG0187	DNA topoisomerase II activity
CYME_CMH190C	COG0537	adenosine 5'-monophosphoramidase activity
CYME_CMH195C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMH197C	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYME_CMH206C	COG2226	methyltransferase
CYME_CMH210C	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYME_CMH212C	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYME_CMH224C	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYME_CMH226C	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYME_CMH229C	COG0659	secondary active sulfate transmembrane transporter activity
CYME_CMH232C	COG0563	adenylate kinase activity
CYME_CMH235C	COG1131	(ABC) transporter
CYME_CMH246C	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYME_CMH255C	COG0483	inositol monophosphate 1-phosphatase activity
CYME_CMH261C	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYME_CMH263C	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYME_CMH271C	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYME_CMH274C	COG0415	Belongs to the DNA photolyase family
CYME_CMH278C	COG1444	tRNA N-acetyltransferase activity
CYME_CMH286C	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYME_CMI016C	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYME_CMI027C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMI038C	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYME_CMI040C	COG3202	ADP transmembrane transporter activity
CYME_CMI041C	COG0194	GDP metabolic process
CYME_CMI042C	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYME_CMI042C	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYME_CMI049C	COG3588	fructose-bisphosphate aldolase
CYME_CMI050C	COG0753	catalase activity
CYME_CMI052C	COG0659	secondary active sulfate transmembrane transporter activity
CYME_CMI055C	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYME_CMI058C	COG1129	ABC transporter
CYME_CMI061C	COG0006	proline dipeptidase activity
CYME_CMI063C	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYME_CMI079C	COG1131	(ABC) transporter
CYME_CMI079C	COG0842	Transport permease protein
CYME_CMI079C	COG1716	ATPase activity
CYME_CMI084C	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYME_CMI088C	COG0842	Transport permease protein
CYME_CMI088C	COG1131	(ABC) transporter
CYME_CMI088C	COG1716	ATPase activity
CYME_CMI091C	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYME_CMI094C	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYME_CMI094C	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYME_CMI095C	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYME_CMI098C	COG0481	GTPase activity
CYME_CMI113C	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYME_CMI117C	COG0488	(ABC) transporter
CYME_CMI119C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMI123C	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYME_CMI130C	COG0612	Peptidase, M16
CYME_CMI135C	COG0629	single-stranded DNA binding
CYME_CMI136C	COG0484	heat shock protein binding
CYME_CMI138C	COG0799	negative regulation of ribosome biogenesis
CYME_CMI142C	COG0129	dihydroxy-acid dehydratase activity
CYME_CMI148C	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYME_CMI156C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMI158C	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYME_CMI169C	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYME_CMI185C	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYME_CMI186C	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CYME_CMI192C	COG1196	nuclear chromosome segregation
CYME_CMI196C	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYME_CMI202C	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYME_CMI204C	COG0563	adenylate kinase activity
CYME_CMI212C	COG2183	response to ionizing radiation
CYME_CMI224C	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYME_CMI229C	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYME_CMI230C	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYME_CMI231C	COG2226	methyltransferase
CYME_CMI232C	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYME_CMI238C	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CYME_CMI240C	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYME_CMI241C	COG0793	Belongs to the peptidase S41A family
CYME_CMI251C	COG0542	response to heat
CYME_CMI252C	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYME_CMI258C	COG0534	Mate efflux family protein
CYME_CMI264C	COG0488	(ABC) transporter
CYME_CMI267C	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYME_CMI273C	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYME_CMI281C	COG0723	plastoquinol--plastocyanin reductase activity
CYME_CMI299C	COG1045	serine acetyltransferase
CYME_CMI300C	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CYME_CMI304C	COG0539	negative regulation of cytoplasmic translation
CYME_CMI313C	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYME_CMJ009C	COG1657	PFAM Prenyltransferase squalene oxidase
CYME_CMJ016C	COG0527	aspartate kinase activity
CYME_CMJ020C	COG2954	triphosphatase activity
CYME_CMJ037C	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYME_CMJ039C	COG1131	(ABC) transporter
CYME_CMJ042C	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYME_CMJ043C	COG1413	lyase activity
CYME_CMJ047C	COG0124	histidyl-tRNA synthetase
CYME_CMJ054C	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYME_CMJ055C	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYME_CMJ066C	COG3186	Phenylalanine-4-hydroxylase
CYME_CMJ072C	COG2226	methyltransferase
CYME_CMJ076C	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CYME_CMJ081C	COG0134	indole-3-glycerol-phosphate synthase activity
CYME_CMJ083C	COG0714	Associated with various cellular activities
CYME_CMJ086C	COG2084	Dehydrogenase
CYME_CMJ093C	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CYME_CMJ098C	COG0442	prolyl-tRNA aminoacylation
CYME_CMJ099C	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CYME_CMJ117C	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYME_CMJ125C	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYME_CMJ130C	COG0415	Belongs to the DNA photolyase family
CYME_CMJ138C	COG1914	H( )-stimulated, divalent metal cation uptake system
CYME_CMJ139C	COG0180	Tryptophanyl-tRNA synthetase
CYME_CMJ141C	COG0740	serine-type endopeptidase activity
CYME_CMJ152C	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYME_CMJ154C	COG0644	oxidoreductase
CYME_CMJ169C	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CYME_CMJ173C	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CYME_CMJ183C	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYME_CMJ185C	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CYME_CMJ186C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMJ191C	COG0133	tryptophan synthase activity
CYME_CMJ198C	COG2890	protein-(glutamine-N5) methyltransferase activity
CYME_CMJ199C	COG0563	adenylate kinase activity
CYME_CMJ200C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMJ216C	COG0488	(ABC) transporter
CYME_CMJ225C	COG1506	peptidase
CYME_CMJ234C	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYME_CMJ235C	COG0081	regulation of translation
CYME_CMJ238C	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYME_CMJ239C	COG0217	transcriptional regulatory protein
CYME_CMJ240C	COG0156	8-amino-7-oxononanoate synthase activity
CYME_CMJ246C	COG0142	geranyltranstransferase activity
CYME_CMJ252C	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CYME_CMJ256C	COG0037	tRNA processing
CYME_CMJ272C	COG0033	Phosphoglucomutase
CYME_CMJ301C	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYME_CMJ305C	COG0126	phosphoglycerate kinase activity
CYME_CMJ306C	COG1185	polyribonucleotide nucleotidyltransferase activity
CYME_CMJ313C	COG1088	dTDP-glucose 4,6-dehydratase activity
CYME_CMJ315C	COG0672	)-iron permease
CYME_CMK011C	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYME_CMK016C	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYME_CMK020C	COG1442	glycosyl transferase family 8
CYME_CMK035C	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYME_CMK037C	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYME_CMK038C	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYME_CMK040C	COG0084	hydrolase, TatD family'
CYME_CMK044C	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYME_CMK045C	COG0101	tRNA pseudouridine synthase activity
CYME_CMK046C	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYME_CMK049C	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CYME_CMK050C	COG0644	oxidoreductase
CYME_CMK051C	COG1965	Belongs to the frataxin family
CYME_CMK058C	COG0142	geranyltranstransferase activity
CYME_CMK060C	COG0105	UTP biosynthetic process
CYME_CMK061C	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYME_CMK063C	COG0730	response to heat
CYME_CMK064C	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CYME_CMK066C	COG2814	Major facilitator Superfamily
CYME_CMK074C	COG0435	Glutathione S-transferase
CYME_CMK087C	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYME_CMK097C	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYME_CMK098C	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYME_CMK105C	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYME_CMK126C	COG0004	ammonium transporteR
CYME_CMK129C	COG1116	anion transmembrane transporter activity
CYME_CMK131C	COG0148	phosphopyruvate hydratase activity
CYME_CMK147C	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYME_CMK150C	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYME_CMK151C	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYME_CMK151C	COG0493	'glutamate synthase
CYME_CMK166C	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYME_CMK172C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMK180C	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CYME_CMK183C	COG1187	pseudouridine synthase activity
CYME_CMK187C	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYME_CMK188C	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CYME_CMK197C	COG0463	Glycosyl transferase, family 2
CYME_CMK204C	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CYME_CMK210C	COG0215	cysteine-tRNA ligase activity
CYME_CMK211C	COG0667	Aldo Keto reductase
CYME_CMK220C	COG0330	HflC and HflK could
CYME_CMK223C	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYME_CMK228C	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYME_CMK228C	COG5373	membrane
CYME_CMK232C	COG0165	Argininosuccinate lyase
CYME_CMK235C	COG1793	dna ligase
CYME_CMK243C	COG0688	phosphatidylethanolamine metabolic process
CYME_CMK247C	COG0300	oxidoreductase activity
CYME_CMK251C	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYME_CMK269C	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYME_CMK273C	COG0089	rRNA binding
CYME_CMK274C	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYME_CMK289C	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CYME_CMK293C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMK294C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMK297C	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYME_CMK305C	COG0484	heat shock protein binding
CYME_CMK307C	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYME_CML004C	COG0672	)-iron permease
CYME_CML007C	COG1088	dTDP-glucose 4,6-dehydratase activity
CYME_CML011C	COG0271	Belongs to the BolA IbaG family
CYME_CML014C	COG0321	lipoyl(octanoyl) transferase activity
CYME_CML015C	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYME_CML016C	COG0708	Exodeoxyribonuclease III
CYME_CML023C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CML025C	COG2815	serine threonine protein kinase
CYME_CML025C	COG0515	serine threonine protein kinase
CYME_CML027C	COG1196	nuclear chromosome segregation
CYME_CML036C	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYME_CML049C	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYME_CML055C	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYME_CML057C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CML058C	COG0322	excinuclease ABC activity
CYME_CML059C	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYME_CML065C	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CYME_CML066C	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CYME_CML066C	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CYME_CML067C	COG2226	methyltransferase
CYME_CML076C	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYME_CML079C	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYME_CML080C	COG1960	acyl-CoA dehydrogenase activity
CYME_CML083C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CML088C	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYME_CML090C	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYME_CML110C	COG0105	UTP biosynthetic process
CYME_CML113C	COG0523	cobalamin synthesis protein
CYME_CML115C	COG0494	nUDIX hydrolase
CYME_CML119C	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CYME_CML126C	COG0134	indole-3-glycerol-phosphate synthase activity
CYME_CML128C	COG0617	tRNA 3'-terminal CCA addition
CYME_CML131C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CML137C	COG0513	Belongs to the DEAD box helicase family
CYME_CML149C	COG1841	ribosomal large subunit assembly
CYME_CML150C	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYME_CML155C	COG0740	serine-type endopeptidase activity
CYME_CML156C	COG0513	Belongs to the DEAD box helicase family
CYME_CML164C	COG1193	negative regulation of DNA recombination
CYME_CML167C	COG0519	Catalyzes the synthesis of GMP from XMP
CYME_CML167C	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYME_CML168C	COG0022	dehydrogenase e1 component
CYME_CML179C	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYME_CML183C	COG1090	epimerase
CYME_CML185C	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYME_CML191C	COG0596	Alpha beta hydrolase
CYME_CML191C	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYME_CML194C	COG0138	bifunctional purine biosynthesis protein purh
CYME_CML196C	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYME_CML197C	COG1022	Amp-dependent synthetase and ligase
CYME_CML198C	COG0564	pseudouridine synthase activity
CYME_CML200C	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYME_CML204C	COG1605	Chorismate mutase
CYME_CML204C	COG0077	Prephenate dehydratase
CYME_CML205C	COG0443	Heat shock 70 kDa protein
CYME_CML209C	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CYME_CML210C	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYME_CML211C	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CYME_CML214C	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYME_CML218C	COG0456	acetyltransferase
CYME_CML225C	COG0156	8-amino-7-oxononanoate synthase activity
CYME_CML231C	COG0489	protein tyrosine kinase activity
CYME_CML249C	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYME_CML252C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CML259C	COG2895	sulfate adenylyltransferase (ATP) activity
CYME_CML259C	COG0529	Catalyzes the synthesis of activated sulfate
CYME_CML262C	COG1914	H( )-stimulated, divalent metal cation uptake system
CYME_CML265C	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYME_CML276C	COG0459	protein refolding
CYME_CML284C	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYME_CML299C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CML307C	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CYME_CML318C	COG0523	cobalamin synthesis protein
CYME_CML322C	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYME_CML323C	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYME_CML329C	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYME_CML330C	COG0187	DNA topoisomerase II activity
CYME_CML336C	COG0513	Belongs to the DEAD box helicase family
CYME_CML339C	COG2072	flavoprotein involved in K transport
CYME_CMM003C	COG0625	glutathione transferase activity
CYME_CMM006C	COG2816	NAD+ diphosphatase activity
CYME_CMM009C	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYME_CMM009C	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYME_CMM013C	COG0343	queuine tRNA-ribosyltransferase activity
CYME_CMM014C	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CYME_CMM017C	COG1088	dTDP-glucose 4,6-dehydratase activity
CYME_CMM019C	COG0539	negative regulation of cytoplasmic translation
CYME_CMM026C	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYME_CMM029C	COG4249	Peptidase C14 caspase catalytic subunit p20
CYME_CMM029C	COG2319	Wd-40 repeat
CYME_CMM034C	COG1034	ATP synthesis coupled electron transport
CYME_CMM044C	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYME_CMM048C	COG1643	Atp-dependent helicase
CYME_CMM062C	COG0579	oxidoreductase
CYME_CMM066C	COG0436	Aminotransferase
CYME_CMM072C	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYME_CMM076C	COG0415	Belongs to the DNA photolyase family
CYME_CMM079C	COG1584	GPR1 FUN34 yaaH family protein
CYME_CMM088C	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CYME_CMM098C	COG0017	Asparaginyl-tRNA synthetase
CYME_CMM104C	COG0612	Peptidase, M16
CYME_CMM112C	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYME_CMM114C	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYME_CMM119C	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYME_CMM121C	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYME_CMM122C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMM132C	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYME_CMM136C	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CYME_CMM140C	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYME_CMM143C	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYME_CMM145C	COG0367	asparagine synthase
CYME_CMM155C	COG0259	pyridoxamine-phosphate oxidase activity
CYME_CMM157C	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYME_CMM162C	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYME_CMM166C	COG1562	ergosterol biosynthetic process
CYME_CMM167C	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYME_CMM178C	COG1252	NADH dehydrogenase
CYME_CMM179C	COG3273	potassium ion transport
CYME_CMM179C	COG0471	metal ion transport
CYME_CMM188C	COG0439	Biotin carboxylase
CYME_CMM190C	COG0203	ribosomal protein L17
CYME_CMM201C	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CYME_CMM209C	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYME_CMM212C	COG0235	Class ii aldolase
CYME_CMM228C	COG0561	phosphatase activity
CYME_CMM229C	COG0473	3-isopropylmalate dehydrogenase activity
CYME_CMM231C	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYME_CMM237C	COG5277	cytoskeleton organization
CYME_CMM249C	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYME_CMM250C	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CYME_CMM253C	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYME_CMM265C	COG0405	Gamma-glutamyltransferase
CYME_CMM270C	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYME_CMM270C	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYME_CMM274C	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYME_CMM281C	COG3688	RNA-binding protein containing a PIN domain
CYME_CMM282C	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYME_CMM284C	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYME_CMM285C	COG3118	belongs to the thioredoxin family
CYME_CMM289C	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYME_CMM292C	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYME_CMM296C	COG0656	L-ascorbic acid biosynthetic process
CYME_CMM298C	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYME_CMM298C	COG2022	thiamine diphosphate biosynthetic process
CYME_CMM299C	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYME_CMM311C	COG0575	Belongs to the CDS family
CYME_CMM314C	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYME_CMM316C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMM317C	COG0297	glycogen (starch) synthase activity
CYME_CMM318C	COG0154	amidase activity
CYME_CMM323C	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYME_CMM323C	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYME_CMM326C	COG2815	serine threonine protein kinase
CYME_CMM326C	COG0515	serine threonine protein kinase
CYME_CMN006C	COG1088	dTDP-glucose 4,6-dehydratase activity
CYME_CMN011C	COG2226	methyltransferase
CYME_CMN017C	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYME_CMN039C	COG0616	signal peptide processing
CYME_CMN048C	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYME_CMN091C	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYME_CMN094C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMN097C	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CYME_CMN105C	COG5265	(ABC) transporter
CYME_CMN111C	COG3118	belongs to the thioredoxin family
CYME_CMN112C	COG0089	rRNA binding
CYME_CMN115C	COG0534	Mate efflux family protein
CYME_CMN118C	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CYME_CMN127C	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYME_CMN138C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMN139C	COG2815	serine threonine protein kinase
CYME_CMN139C	COG0515	serine threonine protein kinase
CYME_CMN148C	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYME_CMN158C	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYME_CMN159C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMN162C	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYME_CMN177C	COG0018	arginyl-trna synthetase
CYME_CMN178C	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYME_CMN180C	COG2264	protein methyltransferase activity
CYME_CMN182C	COG0343	queuine tRNA-ribosyltransferase activity
CYME_CMN192C	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYME_CMN195C	COG1446	asparaginase
CYME_CMN196C	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYME_CMN198C	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CYME_CMN199C	COG0417	DNA replication proofreading
CYME_CMN201C	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYME_CMN202C	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYME_CMN210C	COG1185	polyribonucleotide nucleotidyltransferase activity
CYME_CMN213C	COG0315	cyclic pyranopterin monophosphate synthase activity
CYME_CMN215C	COG0575	Belongs to the CDS family
CYME_CMN228C	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYME_CMN233C	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYME_CMN237C	COG0740	serine-type endopeptidase activity
CYME_CMN243C	COG4770	biotin carboxylase activity
CYME_CMN250C	COG0552	protein localization to endoplasmic reticulum
CYME_CMN251C	COG1132	(ABC) transporter
CYME_CMN264C	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYME_CMN268C	COG1233	COG1233 Phytoene dehydrogenase and related
CYME_CMN295C	COG1716	ATPase activity
CYME_CMN295C	COG1131	(ABC) transporter
CYME_CMN295C	COG0842	Transport permease protein
CYME_CMN318C	COG2211	Major facilitator Superfamily
CYME_CMN323C	COG0436	Aminotransferase
CYME_CMN324C	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYME_CMN325C	COG1132	(ABC) transporter
CYME_CMN332C	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYME_CMO003C	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYME_CMO019C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMO023C	COG1185	polyribonucleotide nucleotidyltransferase activity
CYME_CMO034C	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYME_CMO036C	COG0513	Belongs to the DEAD box helicase family
CYME_CMO044C	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYME_CMO051C	COG0515	serine threonine protein kinase
CYME_CMO053C	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CYME_CMO059C	COG0484	heat shock protein binding
CYME_CMO066C	COG0723	plastoquinol--plastocyanin reductase activity
CYME_CMO071C	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYME_CMO078C	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CYME_CMO083C	COG0612	Peptidase, M16
CYME_CMO089C	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYME_CMO090C	COG0515	serine threonine protein kinase
CYME_CMO090C	COG2815	serine threonine protein kinase
CYME_CMO092C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMO096C	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYME_CMO097C	COG0107	imidazoleglycerol-phosphate synthase activity
CYME_CMO098C	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYME_CMO101C	COG0484	heat shock protein binding
CYME_CMO102C	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CYME_CMO107C	COG0513	Belongs to the DEAD box helicase family
CYME_CMO117C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMO121C	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CYME_CMO124C	COG0166	Belongs to the GPI family
CYME_CMO125C	COG0351	phosphomethylpyrimidine kinase
CYME_CMO126C	COG0756	dUTP diphosphatase activity
CYME_CMO128C	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CYME_CMO130C	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CYME_CMO132C	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYME_CMO136C	COG0408	coproporphyrinogen oxidase activity
CYME_CMO139C	COG0156	8-amino-7-oxononanoate synthase activity
CYME_CMO140C	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYME_CMO141C	COG0633	Ferredoxin
CYME_CMO142C	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYME_CMO144C	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYME_CMO145C	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYME_CMO149C	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CYME_CMO152C	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYME_CMO164C	COG1254	Belongs to the acylphosphatase family
CYME_CMO178C	COG2226	methyltransferase
CYME_CMO183C	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYME_CMO192C	COG1234	tRNA 3'-trailer cleavage
CYME_CMO207C	COG2815	serine threonine protein kinase
CYME_CMO207C	COG0515	serine threonine protein kinase
CYME_CMO208C	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYME_CMO211C	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CYME_CMO212C	COG1429	ligase activity, forming nitrogen-metal bonds
CYME_CMO215C	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYME_CMO222C	COG2119	membrane
CYME_CMO229C	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYME_CMO242C	COG0251	oxidation-reduction process
CYME_CMO244C	COG1999	signal sequence binding
CYME_CMO245C	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYME_CMO246C	COG0724	RNA recognition motif
CYME_CMO272C	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYME_CMO275C	COG0590	tRNA wobble adenosine to inosine editing
CYME_CMO276C	COG0837	glucose binding
CYME_CMO281C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMO283C	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYME_CMO287C	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYME_CMO289C	COG0494	nUDIX hydrolase
CYME_CMO290C	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYME_CMO291C	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYME_CMO300C	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYME_CMO306C	COG0673	inositol 2-dehydrogenase activity
CYME_CMO314C	COG4447	cellulose binding
CYME_CMO322C	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYME_CMO324C	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYME_CMO324C	COG0512	Glutamine amidotransferase of anthranilate synthase
CYME_CMO328C	COG2211	Major facilitator Superfamily
CYME_CMO340C	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CYME_CMO341C	COG0793	Belongs to the peptidase S41A family
CYME_CMO345C	COG1012	belongs to the aldehyde dehydrogenase family
CYME_CMO348C	COG0415	Belongs to the DNA photolyase family
CYME_CMO363C	COG0166	Belongs to the GPI family
CYME_CMP007C	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYME_CMP017C	COG1355	regulation of microtubule-based process
CYME_CMP018C	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYME_CMP028C	COG4178	(ABC) transporter
CYME_CMP037C	COG1678	Uncharacterized ACR, COG1678
CYME_CMP046C	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYME_CMP052C	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYME_CMP067C	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYME_CMP070C	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CYME_CMP083C	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYME_CMP090C	COG0515	serine threonine protein kinase
CYME_CMP110C	COG0300	oxidoreductase activity
CYME_CMP114C	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYME_CMP119C	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYME_CMP119C	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYME_CMP122C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMP126C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMP128C	COG2815	serine threonine protein kinase
CYME_CMP128C	COG0515	serine threonine protein kinase
CYME_CMP129C	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYME_CMP145C	COG0443	Heat shock 70 kDa protein
CYME_CMP149C	COG2239	Acts as a magnesium transporter
CYME_CMP155C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMP158C	COG0673	inositol 2-dehydrogenase activity
CYME_CMP160C	COG0616	signal peptide processing
CYME_CMP164C	COG0571	ribonuclease III activity
CYME_CMP165C	COG0398	Pfam SNARE associated Golgi protein
CYME_CMP170C	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYME_CMP188C	COG0666	response to abiotic stimulus
CYME_CMP189C	COG0709	Synthesizes selenophosphate from selenide and ATP
CYME_CMP193C	COG0039	L-malate dehydrogenase activity
CYME_CMP201C	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYME_CMP205C	COG0495	leucyl-tRNA aminoacylation
CYME_CMP214C	COG0352	thiamine-phosphate diphosphorylase activity
CYME_CMP215C	COG2217	Heavy metal translocating P-type atpase
CYME_CMP216C	COG0504	CTP synthase activity
CYME_CMP217C	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYME_CMP219C	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CYME_CMP225C	COG0003	Pfam Anion-transporting ATPase
CYME_CMP234C	COG0131	Imidazoleglycerol-phosphate dehydratase
CYME_CMP235C	COG0003	Pfam Anion-transporting ATPase
CYME_CMP253C	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYME_CMP260C	COG0469	pyruvate kinase activity
CYME_CMP261C	COG0668	transmembrane transport
CYME_CMP275C	COG2226	methyltransferase
CYME_CMP277C	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYME_CMP285C	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYME_CMP294C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMP297C	COG0793	Belongs to the peptidase S41A family
CYME_CMP300C	COG1523	belongs to the glycosyl hydrolase 13 family
CYME_CMP301C	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYME_CMP308C	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYME_CMP312C	COG0515	serine threonine protein kinase
CYME_CMP315C	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYME_CMP345C	COG0525	valine-tRNA ligase activity
CYME_CMP347C	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYME_CMP352C	COG1640	4-alpha-glucanotransferase
CYME_CMP354C	COG2271	Major facilitator Superfamily
CYME_CMP355C	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CYME_CMQ006C	COG1088	dTDP-glucose 4,6-dehydratase activity
CYME_CMQ021C	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYME_CMQ022C	COG0193	aminoacyl-tRNA hydrolase activity
CYME_CMQ023C	COG0095	Lipoate-protein ligase
CYME_CMQ024C	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYME_CMQ029C	COG1982	Orn Lys Arg decarboxylase major
CYME_CMQ030C	COG1085	galactose-1-phosphate uridylyltransferase
CYME_CMQ041C	COG0101	tRNA pseudouridine synthase activity
CYME_CMQ044C	COG0515	serine threonine protein kinase
CYME_CMQ044C	COG2815	serine threonine protein kinase
CYME_CMQ045C	COG0740	serine-type endopeptidase activity
CYME_CMQ053C	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYME_CMQ053C	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYME_CMQ064C	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYME_CMQ067C	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYME_CMQ068C	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYME_CMQ082C	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYME_CMQ087C	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYME_CMQ089C	COG0612	Peptidase, M16
CYME_CMQ093C	COG3118	belongs to the thioredoxin family
CYME_CMQ101C	COG0405	Gamma-glutamyltransferase
CYME_CMQ120C	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CYME_CMQ127C	COG0671	phosphoesterase, PA-phosphatase related
CYME_CMQ128C	COG2081	HI0933 family
CYME_CMQ129C	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYME_CMQ134C	COG2226	methyltransferase
CYME_CMQ149C	COG4581	dead DEAH box helicase
CYME_CMQ154C	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYME_CMQ158C	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYME_CMQ167C	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYME_CMQ172C	COG0149	triose-phosphate isomerase activity
CYME_CMQ173C	COG0515	serine threonine protein kinase
CYME_CMQ173C	COG2815	serine threonine protein kinase
CYME_CMQ175C	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYME_CMQ176C	COG5265	(ABC) transporter
CYME_CMQ200C	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYME_CMQ201C	COG0483	inositol monophosphate 1-phosphatase activity
CYME_CMQ204C	COG2815	serine threonine protein kinase
CYME_CMQ204C	COG0515	serine threonine protein kinase
CYME_CMQ208C	COG0484	heat shock protein binding
CYME_CMQ209C	COG2815	serine threonine protein kinase
CYME_CMQ209C	COG0515	serine threonine protein kinase
CYME_CMQ211C	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYME_CMQ213C	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYME_CMQ219C	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CYME_CMQ219C	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYME_CMQ224C	COG0326	Molecular chaperone. Has ATPase activity
CYME_CMQ230C	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYME_CMQ232C	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CYME_CMQ233C	COG1073	alpha beta
CYME_CMQ234C	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYME_CMQ241C	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYME_CMQ243C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMQ250C	COG3830	Belongs to the UPF0237 family
CYME_CMQ250C	COG0560	Phosphoserine phosphatase
CYME_CMQ255C	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYME_CMQ260C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMQ264C	COG2271	Major facilitator Superfamily
CYME_CMQ271C	COG1515	deoxyribonuclease V activity
CYME_CMQ274C	COG4221	oxidoreductase activity
CYME_CMQ275C	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYME_CMQ284C	COG0387	Pfam Sodium calcium exchanger
CYME_CMQ286C	COG0358	DNA primase activity
CYME_CMQ289C	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYME_CMQ290C	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYME_CMQ292C	COG0200	Binds to the 23S rRNA
CYME_CMQ295C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMQ300C	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYME_CMQ301C	COG1064	alcohol dehydrogenase
CYME_CMQ306C	COG2264	protein methyltransferase activity
CYME_CMQ324C	COG1185	polyribonucleotide nucleotidyltransferase activity
CYME_CMQ330C	COG2967	ApaG domain
CYME_CMQ331C	COG1643	Atp-dependent helicase
CYME_CMQ336C	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYME_CMQ337C	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYME_CMQ338C	COG0513	Belongs to the DEAD box helicase family
CYME_CMQ345C	COG1160	GTP binding
CYME_CMQ347C	COG0277	FAD linked oxidase domain protein
CYME_CMQ350C	COG0655	NAD(P)H dehydrogenase (quinone) activity
CYME_CMQ354C	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYME_CMQ359C	COG1482	cell wall glycoprotein biosynthetic process
CYME_CMQ363C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMQ365C	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYME_CMQ365C	COG0047	phosphoribosylformylglycinamidine synthase activity
CYME_CMQ369C	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CYME_CMQ374C	COG0484	heat shock protein binding
CYME_CMQ379C	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYME_CMQ383C	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYME_CMQ393C	COG0653	protein targeting
CYME_CMQ410C	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYME_CMQ415C	COG2226	methyltransferase
CYME_CMQ421C	COG0088	Forms part of the polypeptide exit tunnel
CYME_CMQ441C	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYME_CMQ453C	COG0415	Belongs to the DNA photolyase family
CYME_CMQ457C	COG2815	serine threonine protein kinase
CYME_CMQ457C	COG0515	serine threonine protein kinase
CYME_CMQ461C	COG0233	cytoplasmic translational termination
CYME_CMR012C	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYME_CMR014C	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYME_CMR015C	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYME_CMR015C	COG0438	transferase activity, transferring glycosyl groups
CYME_CMR024C	COG0250	Participates in transcription elongation, termination and antitermination
CYME_CMR028C	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYME_CMR030C	COG0750	zinc metalloprotease
CYME_CMR042C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMR052C	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYME_CMR053C	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYME_CMR105C	COG5505	Protein of unknown function (DUF819)
CYME_CMR109C	COG1217	gtp-binding protein TYPA
CYME_CMR110C	COG0625	glutathione transferase activity
CYME_CMR117C	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYME_CMR118C	COG1098	S1 RNA binding domain
CYME_CMR121C	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYME_CMR129C	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYME_CMR140C	COG0481	GTPase activity
CYME_CMR158C	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYME_CMR165C	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYME_CMR167C	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYME_CMR177C	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYME_CMR179C	COG0222	ribosome binding
CYME_CMR181C	COG0668	transmembrane transport
CYME_CMR188C	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CYME_CMR193C	COG2815	serine threonine protein kinase
CYME_CMR193C	COG0515	serine threonine protein kinase
CYME_CMR198C	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYME_CMR199C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMR201C	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYME_CMR211C	COG0484	heat shock protein binding
CYME_CMR224C	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYME_CMR237C	COG1063	alcohol dehydrogenase
CYME_CMR240C	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYME_CMR244C	COG0673	inositol 2-dehydrogenase activity
CYME_CMR246C	COG1346	cytolysis
CYME_CMR254C	COG0295	cytidine deaminase activity
CYME_CMR256C	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYME_CMR259C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMR268C	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYME_CMR269C	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CYME_CMR270C	COG5277	cytoskeleton organization
CYME_CMR275C	COG0271	Belongs to the BolA IbaG family
CYME_CMR277C	COG0321	lipoyl(octanoyl) transferase activity
CYME_CMR278C	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYME_CMR282C	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYME_CMR282C	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYME_CMR284C	COG0003	Pfam Anion-transporting ATPase
CYME_CMR287C	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYME_CMR288C	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYME_CMR291C	COG1131	(ABC) transporter
CYME_CMR291C	COG0842	Transport permease protein
CYME_CMR291C	COG1716	ATPase activity
CYME_CMR298C	COG0484	heat shock protein binding
CYME_CMR306C	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYME_CMR311C	COG0489	protein tyrosine kinase activity
CYME_CMR312C	COG3012	SEC-C Motif Domain Protein
CYME_CMR313C	COG1164	Oligoendopeptidase f
CYME_CMR318C	COG0822	iron-sulfur transferase activity
CYME_CMR339C	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYME_CMR346C	COG0438	transferase activity, transferring glycosyl groups
CYME_CMR349C	COG0277	FAD linked oxidase domain protein
CYME_CMR358C	COG1442	glycosyl transferase family 8
CYME_CMR368C	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CYME_CMR370C	COG0385	Bile acid
CYME_CMR373C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMR389C	COG0802	atpase or kinase
CYME_CMR392C	COG0724	RNA recognition motif
CYME_CMR398C	COG0673	inositol 2-dehydrogenase activity
CYME_CMR399C	COG1335	isochorismatase
CYME_CMR420C	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYME_CMR421C	COG0647	UMP catabolic process
CYME_CMR425C	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYME_CMR432C	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYME_CMR445C	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYME_CMR459C	COG3001	Fructosamine kinase
CYME_CMR465C	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYME_CMR474C	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYME_CMR475C	COG0673	inositol 2-dehydrogenase activity
CYME_CMR476C	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYME_CMR479C	COG0513	Belongs to the DEAD box helicase family
CYME_CMS004C	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYME_CMS007C	COG0693	protein deglycase activity
CYME_CMS024C	COG0442	prolyl-tRNA aminoacylation
CYME_CMS030C	COG1836	PFAM Integral membrane protein DUF92
CYME_CMS035C	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYME_CMS047C	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYME_CMS052C	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CYME_CMS052C	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CYME_CMS053C	COG0275	rRNA processing
CYME_CMS056C	COG0575	Belongs to the CDS family
CYME_CMS061C	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYME_CMS068C	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYME_CMS078C	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYME_CMS084C	COG1957	nucleoside hydrolase
CYME_CMS096C	COG2046	Belongs to the sulfate adenylyltransferase family
CYME_CMS114C	COG0085	RNA polymerase activity
CYME_CMS120C	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYME_CMS124C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMS128C	COG0542	response to heat
CYME_CMS131C	COG2166	iron-sulfur cluster assembly
CYME_CMS146C	COG2815	serine threonine protein kinase
CYME_CMS146C	COG0515	serine threonine protein kinase
CYME_CMS164C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMS169C	COG0463	Glycosyl transferase, family 2
CYME_CMS190C	COG1489	DNA binding
CYME_CMS192C	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYME_CMS193C	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYME_CMS195C	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYME_CMS208C	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYME_CMS212C	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYME_CMS217C	COG0009	L-threonylcarbamoyladenylate synthase
CYME_CMS223C	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYME_CMS227C	COG2226	methyltransferase
CYME_CMS228C	COG2267	carboxylic ester hydrolase activity
CYME_CMS231C	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CYME_CMS243C	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYME_CMS248C	COG0513	Belongs to the DEAD box helicase family
CYME_CMS253C	COG0590	tRNA wobble adenosine to inosine editing
CYME_CMS264C	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CYME_CMS271C	COG3118	belongs to the thioredoxin family
CYME_CMS272C	COG0473	3-isopropylmalate dehydrogenase activity
CYME_CMS279C	COG2119	membrane
CYME_CMS289C	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYME_CMS295C	COG0515	serine threonine protein kinase
CYME_CMS295C	COG2815	serine threonine protein kinase
CYME_CMS299C	COG0439	Biotin carboxylase
CYME_CMS308C	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYME_CMS316C	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYME_CMS319C	COG2124	cytochrome p450
CYME_CMS327C	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYME_CMS327C	COG0022	dehydrogenase e1 component
CYME_CMS337C	COG0590	tRNA wobble adenosine to inosine editing
CYME_CMS339C	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CYME_CMS341C	COG0308	aminopeptidase N
CYME_CMS343C	COG0443	Heat shock 70 kDa protein
CYME_CMS344C	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYME_CMS345C	COG0515	serine threonine protein kinase
CYME_CMS345C	COG2815	serine threonine protein kinase
CYME_CMS352C	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYME_CMS352C	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYME_CMS361C	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYME_CMS362C	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CYME_CMS364C	COG0628	permease
CYME_CMS370C	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CYME_CMS384C	COG0515	serine threonine protein kinase
CYME_CMS384C	COG2815	serine threonine protein kinase
CYME_CMS393C	COG1028	Short-chain dehydrogenase reductase Sdr
CYME_CMS394C	COG0501	Belongs to the peptidase M48B family
CYME_CMS398C	COG0436	Aminotransferase
CYME_CMS400C	COG0390	transport system, permease component
CYME_CMS401C	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CYME_CMS406C	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYME_CMS407C	COG2363	Small membrane protein
CYME_CMS413C	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYME_CMS417C	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYME_CMS424C	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYME_CMS425C	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYME_CMS428C	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYME_CMS429C	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CYME_CMS440C	COG0740	serine-type endopeptidase activity
CYME_CMS444C	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYME_CMS446C	COG0339	signal peptide processing
CYME_CMS447C	COG0251	oxidation-reduction process
CYME_CMS462C	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CYME_CMS464C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMS467C	COG0842	Transport permease protein
CYME_CMS467C	COG1716	ATPase activity
CYME_CMS467C	COG1131	(ABC) transporter
CYME_CMS468C	COG0564	pseudouridine synthase activity
CYME_CMS475C	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYME_CMS480C	COG0494	nUDIX hydrolase
CYME_CMS482C	COG0456	acetyltransferase
CYME_CMS483C	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYME_CMS484C	COG0194	GDP metabolic process
CYME_CMS498C	COG0352	thiamine-phosphate diphosphorylase activity
CYME_CMS502C	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYME_CMT024C	COG2226	methyltransferase
CYME_CMT025C	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CYME_CMT034C	COG1012	belongs to the aldehyde dehydrogenase family
CYME_CMT043C	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CYME_CMT045C	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYME_CMT058C	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CYME_CMT061C	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYME_CMT063C	COG0706	membrane insertase activity
CYME_CMT066C	COG5265	(ABC) transporter
CYME_CMT071C	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYME_CMT072C	COG1960	acyl-CoA dehydrogenase activity
CYME_CMT074C	COG1024	Enoyl-CoA hydratase
CYME_CMT075C	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYME_CMT083C	COG0563	adenylate kinase activity
CYME_CMT093C	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYME_CMT110C	COG2046	Belongs to the sulfate adenylyltransferase family
CYME_CMT113C	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYME_CMT114C	COG1185	polyribonucleotide nucleotidyltransferase activity
CYME_CMT117C	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYME_CMT119C	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYME_CMT120C	COG1132	(ABC) transporter
CYME_CMT122C	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CYME_CMT130C	COG1160	GTP binding
CYME_CMT131C	COG0513	Belongs to the DEAD box helicase family
CYME_CMT143C	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYME_CMT165C	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CYME_CMT172C	COG0464	growth
CYME_CMT173C	COG0513	Belongs to the DEAD box helicase family
CYME_CMT174C	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYME_CMT177C	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYME_CMT180C	COG1914	H( )-stimulated, divalent metal cation uptake system
CYME_CMT184C	COG0012	GTP binding
CYME_CMT185C	COG0515	serine threonine protein kinase
CYME_CMT202C	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYME_CMT204C	COG1640	4-alpha-glucanotransferase
CYME_CMT205C	COG0037	tRNA processing
CYME_CMT207C	COG0459	protein refolding
CYME_CMT209C	COG0045	succinate-CoA ligase (ADP-forming) activity
CYME_CMT210C	COG0343	queuine tRNA-ribosyltransferase activity
CYME_CMT216C	COG0538	isocitrate dehydrogenase activity
CYME_CMT218C	COG1073	alpha beta
CYME_CMT220C	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYME_CMT227C	COG0793	Belongs to the peptidase S41A family
CYME_CMT228C	COG0823	Involved in the tonB-independent uptake of proteins
CYME_CMT228C	COG4946	Tricorn protease homolog
CYME_CMT228C	COG1506	peptidase
CYME_CMT232C	COG0109	protoheme IX farnesyltransferase activity
CYME_CMT240C	COG0134	indole-3-glycerol-phosphate synthase activity
CYME_CMT244C	COG1842	Phage shock protein A
CYME_CMT256C	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYME_CMT264C	COG0316	Belongs to the HesB IscA family
CYME_CMT265C	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CYME_CMT269C	COG0515	serine threonine protein kinase
CYME_CMT269C	COG2815	serine threonine protein kinase
CYME_CMT278C	COG0482	sulfurtransferase activity
CYME_CMT280C	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYME_CMT284C	COG2814	Major facilitator Superfamily
CYME_CMT285C	COG0033	Phosphoglucomutase
CYME_CMT292C	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYME_CMT298C	COG0121	glutamine amidotransferase
CYME_CMT304C	COG0667	Aldo Keto reductase
CYME_CMT305C	COG0137	argininosuccinate synthase activity
CYME_CMT308C	COG0415	Belongs to the DNA photolyase family
CYME_CMT312C	COG3621	Patatin-like phospholipase
CYME_CMT313C	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYME_CMT322C	COG0459	protein refolding
CYME_CMT325C	COG0515	serine threonine protein kinase
CYME_CMT325C	COG2815	serine threonine protein kinase
CYME_CMT328C	COG2815	serine threonine protein kinase
CYME_CMT328C	COG0515	serine threonine protein kinase
CYME_CMT329C	COG2267	carboxylic ester hydrolase activity
CYME_CMT330C	COG0052	Belongs to the universal ribosomal protein uS2 family
CYME_CMT333C	COG2814	Major facilitator Superfamily
CYME_CMT353C	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYME_CMT362C	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYME_CMT373C	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYME_CMT378C	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYME_CMT379C	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CYME_CMT380C	COG0482	sulfurtransferase activity
CYME_CMT381C	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYME_CMT384C	COG0563	adenylate kinase activity
CYME_CMT389C	COG0626	cystathionine gamma-synthase activity
CYME_CMT390C	COG0564	pseudouridine synthase activity
CYME_CMT392C	COG0779	Required for maturation of 30S ribosomal subunits
CYME_CMT407C	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYME_CMT412C	COG0473	3-isopropylmalate dehydrogenase activity
CYME_CMT419C	COG0233	cytoplasmic translational termination
CYME_CMT420C	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYME_CMT423C	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYME_CMT427C	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYME_CMT434C	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYME_CMT435C	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYME_CMT439C	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYME_CMT441C	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYME_CMT445C	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYME_CMT459C	COG1022	Amp-dependent synthetase and ligase
CYME_CMT471C	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYME_CMT478C	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYME_CMT486C	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYME_CMT488C	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYME_CMT489C	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYME_CMT491C	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYME_CMT492C	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CYME_CMT493C	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYME_CMT497C	COG0166	Belongs to the GPI family
CYME_CMT508C	COG0203	ribosomal protein L17
CYME_CMT511C	COG1234	tRNA 3'-trailer cleavage
CYME_CMT518C	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CYME_CMT526C	COG0004	ammonium transporteR
CYME_CMT533C	COG0436	Aminotransferase
CYME_CMT536C	COG1230	cation diffusion facilitator family transporter
CYME_CMT543C	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYME_CMT544C	COG0228	four-way junction DNA binding
CYME_CMT558C	COG0459	protein refolding
CYME_CMT561C	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CYME_CMT571C	COG0563	adenylate kinase activity
CYME_CMT579C	COG0443	Heat shock 70 kDa protein
CYME_CMT582C	COG1053	succinate dehydrogenase
CYME_CMT584C	COG0418	dihydroorotase activity
CYME_CMT588C	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYME_CMT592C	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CYME_CMT592C	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYME_CMT600C	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CYME_CMT610C	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CYME_CMT611C	COG0039	L-malate dehydrogenase activity
CYME_CMT613C	COG0484	heat shock protein binding
CYME_CMT623C	COG0484	heat shock protein binding
CYME_CMT625C	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYME_CMT626C	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYME_CMT627C	COG0049	tRNA binding
CYME_CMT633C	COG0036	Belongs to the ribulose-phosphate 3-epimerase family