locus-tag	class	description
CYAGR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYAGR_RS00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYAGR_RS00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYAGR_RS00065	COG4451	ribulose bisphosphate carboxylase, small
CYAGR_RS00070	COG1850	ribulose-bisphosphate carboxylase activity
CYAGR_RS00075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYAGR_RS00090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYAGR_RS00095	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CYAGR_RS00110	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYAGR_RS00115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CYAGR_RS00120	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYAGR_RS00155	COG0095	Lipoate-protein ligase
CYAGR_RS00160	COG1994	Peptidase M50
CYAGR_RS00160	COG0517	IMP dehydrogenase activity
CYAGR_RS00165	COG0135	phosphoribosylanthranilate isomerase activity
CYAGR_RS00175	COG0302	gtp cyclohydrolase
CYAGR_RS00185	COG0825	malonyl-CoA metabolic process
CYAGR_RS00190	COG5322	oxidoreductase activity
CYAGR_RS00195	COG3396	Phenylacetate-CoA oxygenase
CYAGR_RS00205	COG0539	negative regulation of cytoplasmic translation
CYAGR_RS00220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CYAGR_RS00225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYAGR_RS00225	COG0574	Belongs to the PEP-utilizing enzyme family
CYAGR_RS00240	COG0028	Belongs to the TPP enzyme family
CYAGR_RS00250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYAGR_RS00265	COG0528	UMP kinase activity
CYAGR_RS00270	COG0233	cytoplasmic translational termination
CYAGR_RS00275	COG0644	oxidoreductase
CYAGR_RS00285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYAGR_RS00290	COG0768	penicillin binding
CYAGR_RS00305	COG0406	alpha-ribazole phosphatase activity
CYAGR_RS00345	COG0442	prolyl-tRNA aminoacylation
CYAGR_RS00360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYAGR_RS00375	COG0629	single-stranded DNA binding
CYAGR_RS00390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYAGR_RS00400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CYAGR_RS00405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS00430	COG0181	hydroxymethylbilane synthase activity
CYAGR_RS00445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYAGR_RS00485	COG3239	Fatty acid desaturase
CYAGR_RS00490	COG0432	Pfam Uncharacterised protein family UPF0047
CYAGR_RS00495	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYAGR_RS00525	COG0542	response to heat
CYAGR_RS00540	COG2010	Cytochrome c
CYAGR_RS00550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYAGR_RS00555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYAGR_RS00590	COG2801	Transposase and inactivated derivatives
CYAGR_RS00595	COG1484	DNA-dependent DNA replication
CYAGR_RS00625	COG3039	Transposase
CYAGR_RS00645	COG1940	carbohydrate kinase activity
CYAGR_RS00650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYAGR_RS00655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYAGR_RS00710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYAGR_RS00715	COG2801	Transposase and inactivated derivatives
CYAGR_RS00755	COG4974	Belongs to the 'phage' integrase family
CYAGR_RS00840	COG1295	ribonuclease BN
CYAGR_RS00860	COG0390	transport system, permease component
CYAGR_RS00865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYAGR_RS00875	COG0435	Glutathione S-transferase
CYAGR_RS00930	COG0598	Magnesium transport protein CorA
CYAGR_RS00950	COG1054	Belongs to the UPF0176 family
CYAGR_RS00955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYAGR_RS00960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYAGR_RS00965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CYAGR_RS00970	COG0019	diaminopimelate decarboxylase activity
CYAGR_RS00975	COG0456	acetyltransferase
CYAGR_RS00980	COG0542	response to heat
CYAGR_RS00985	COG0371	Dehydrogenase
CYAGR_RS00990	COG0596	Alpha beta hydrolase
CYAGR_RS01015	COG0575	Belongs to the CDS family
CYAGR_RS01020	COG2242	protein methyltransferase activity
CYAGR_RS01020	COG2241	protein methyltransferase activity
CYAGR_RS01025	COG1982	Orn Lys Arg decarboxylase major
CYAGR_RS01030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYAGR_RS01055	COG0724	RNA recognition motif
CYAGR_RS01060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS01065	COG1187	pseudouridine synthase activity
CYAGR_RS01080	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CYAGR_RS01110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYAGR_RS01145	COG1111	helicase
CYAGR_RS01145	COG1205	dead DEAH box helicase
CYAGR_RS01150	COG0210	DNA helicase
CYAGR_RS01185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYAGR_RS01205	COG0308	aminopeptidase N
CYAGR_RS01215	COG0842	Transport permease protein
CYAGR_RS01215	COG1716	ATPase activity
CYAGR_RS01215	COG1131	(ABC) transporter
CYAGR_RS01230	COG2801	Transposase and inactivated derivatives
CYAGR_RS01235	COG1132	(ABC) transporter
CYAGR_RS01255	COG2801	Transposase and inactivated derivatives
CYAGR_RS01315	COG2205	protein histidine kinase activity
CYAGR_RS01335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYAGR_RS01340	COG3429	Glucose-6-phosphate dehydrogenase subunit
CYAGR_RS01340	COG3409	Peptidoglycan-binding domain 1 protein
CYAGR_RS01345	COG1797	cobyrinic acid a,c-diamide synthase activity
CYAGR_RS01350	COG1254	Belongs to the acylphosphatase family
CYAGR_RS01385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYAGR_RS01390	COG1480	7TM receptor with intracellular HD hydrolase
CYAGR_RS01395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYAGR_RS01400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYAGR_RS01420	COG0395	ABC-type sugar transport system, permease component
CYAGR_RS01425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYAGR_RS01430	COG1543	Belongs to the glycosyl hydrolase 57 family
CYAGR_RS01435	COG1126	abc transporter atp-binding protein
CYAGR_RS01440	COG0765	amino acid transport
CYAGR_RS01445	COG4597	amino acid ABC transporter
CYAGR_RS01450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYAGR_RS01455	COG2801	Transposase and inactivated derivatives
CYAGR_RS01465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYAGR_RS01470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYAGR_RS01475	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYAGR_RS01485	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS01490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYAGR_RS01495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYAGR_RS01500	COG0475	glutathione-regulated potassium exporter activity
CYAGR_RS01505	COG0531	amino acid
CYAGR_RS01510	COG3273	potassium ion transport
CYAGR_RS01510	COG0471	metal ion transport
CYAGR_RS01515	COG0586	Pfam SNARE associated Golgi protein
CYAGR_RS01525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYAGR_RS01530	COG0242	peptide deformylase activity
CYAGR_RS01550	COG0418	dihydroorotase activity
CYAGR_RS01565	COG0393	Putative heavy-metal-binding
CYAGR_RS01570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CYAGR_RS01580	COG0297	glycogen (starch) synthase activity
CYAGR_RS01585	COG1376	ErfK ybiS ycfS ynhG family protein
CYAGR_RS01600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYAGR_RS01610	COG1215	transferase activity, transferring glycosyl groups
CYAGR_RS01615	COG1215	transferase activity, transferring glycosyl groups
CYAGR_RS01620	COG2244	polysaccharide biosynthetic process
CYAGR_RS01645	COG4191	Histidine kinase
CYAGR_RS01650	COG0784	Response regulator, receiver
CYAGR_RS01650	COG5002	protein histidine kinase activity
CYAGR_RS01660	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS01675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CYAGR_RS01680	COG0681	Belongs to the peptidase S26 family
CYAGR_RS01695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYAGR_RS01700	COG1121	(ABC) transporter
CYAGR_RS01730	COG0180	Tryptophanyl-tRNA synthetase
CYAGR_RS01745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYAGR_RS01750	COG0837	glucose binding
CYAGR_RS01755	COG0083	homoserine kinase activity
CYAGR_RS01760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS01765	COG0339	signal peptide processing
CYAGR_RS01770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYAGR_RS01790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYAGR_RS01805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYAGR_RS01810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYAGR_RS01810	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CYAGR_RS01815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYAGR_RS01830	COG0463	Glycosyl transferase, family 2
CYAGR_RS01835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYAGR_RS01840	COG1959	2 iron, 2 sulfur cluster binding
CYAGR_RS01845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYAGR_RS01850	COG2045	Belongs to the ComB family
CYAGR_RS01865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CYAGR_RS01870	COG0142	geranyltranstransferase activity
CYAGR_RS01875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYAGR_RS01890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYAGR_RS01900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYAGR_RS01935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYAGR_RS01945	COG1132	(ABC) transporter
CYAGR_RS01955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYAGR_RS01960	COG0505	Belongs to the CarA family
CYAGR_RS01970	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CYAGR_RS01975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYAGR_RS01985	COG0154	amidase activity
CYAGR_RS02005	COG0587	DNA-directed DNA polymerase activity
CYAGR_RS02015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYAGR_RS02020	COG0632	four-way junction helicase activity
CYAGR_RS02030	COG3263	regulation of cellular component size
CYAGR_RS02040	COG0358	DNA primase activity
CYAGR_RS02045	COG2203	Gaf domain
CYAGR_RS02045	COG2199	diguanylate cyclase activity
CYAGR_RS02050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYAGR_RS02055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYAGR_RS02070	COG1716	ATPase activity
CYAGR_RS02070	COG5001	Diguanylate cyclase
CYAGR_RS02095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYAGR_RS02100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYAGR_RS02110	COG0022	dehydrogenase e1 component
CYAGR_RS02110	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYAGR_RS02115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYAGR_RS02120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYAGR_RS02135	COG0628	permease
CYAGR_RS02145	COG0515	serine threonine protein kinase
CYAGR_RS02165	COG0174	glutamine synthetase
CYAGR_RS02175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CYAGR_RS02185	COG0076	glutamate decarboxylase activity
CYAGR_RS02190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYAGR_RS02195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYAGR_RS02200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYAGR_RS02220	COG0612	Peptidase, M16
CYAGR_RS02245	COG1216	Glycosyl transferase, family 2
CYAGR_RS02250	COG0052	Belongs to the universal ribosomal protein uS2 family
CYAGR_RS02255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYAGR_RS02265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYAGR_RS02270	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CYAGR_RS02280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYAGR_RS02285	COG0751	glycine-tRNA ligase activity
CYAGR_RS02305	COG1253	flavin adenine dinucleotide binding
CYAGR_RS02310	COG0644	oxidoreductase
CYAGR_RS02320	COG1217	gtp-binding protein TYPA
CYAGR_RS02345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYAGR_RS02355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYAGR_RS02360	COG1494	fructose-1,6-bisphosphatase
CYAGR_RS02365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYAGR_RS02370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYAGR_RS02375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYAGR_RS02380	COG0363	glucosamine-6-phosphate deaminase activity
CYAGR_RS02410	COG0129	dihydroxy-acid dehydratase activity
CYAGR_RS02420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYAGR_RS02440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYAGR_RS02445	COG0047	phosphoribosylformylglycinamidine synthase activity
CYAGR_RS02450	COG0450	alkyl hydroperoxide reductase
CYAGR_RS02470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYAGR_RS02500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYAGR_RS02520	COG0557	exoribonuclease II activity
CYAGR_RS02525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYAGR_RS02530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYAGR_RS02535	COG0072	phenylalanine-tRNA ligase activity
CYAGR_RS02535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYAGR_RS02540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYAGR_RS02575	COG2385	sporulation resulting in formation of a cellular spore
CYAGR_RS02580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYAGR_RS02605	COG0646	methionine synthase
CYAGR_RS02605	COG1410	methionine synthase
CYAGR_RS02610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYAGR_RS02625	COG0587	DNA-directed DNA polymerase activity
CYAGR_RS02630	COG1981	membrane
CYAGR_RS02640	COG0322	excinuclease ABC activity
CYAGR_RS02645	COG0426	domain, Protein
CYAGR_RS02645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYAGR_RS02650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYAGR_RS02660	COG2027	D-alanyl-D-alanine carboxypeptidase
CYAGR_RS02675	COG1104	cysteine desulfurase activity
CYAGR_RS02680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYAGR_RS02690	COG0495	leucyl-tRNA aminoacylation
CYAGR_RS02700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CYAGR_RS02705	COG0166	Belongs to the GPI family
CYAGR_RS02735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYAGR_RS02740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYAGR_RS02740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYAGR_RS02755	COG2274	protein secretion by the type I secretion system
CYAGR_RS02775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYAGR_RS02780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CYAGR_RS02785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CYAGR_RS02795	COG0484	heat shock protein binding
CYAGR_RS02800	COG0443	Heat shock 70 kDa protein
CYAGR_RS02805	COG0573	inorganic phosphate transmembrane transporter activity
CYAGR_RS02810	COG0581	inorganic phosphate transmembrane transporter activity
CYAGR_RS02815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYAGR_RS02825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYAGR_RS02830	COG0483	inositol monophosphate 1-phosphatase activity
CYAGR_RS02835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CYAGR_RS02845	COG0326	Molecular chaperone. Has ATPase activity
CYAGR_RS02850	COG1653	transport
CYAGR_RS02865	COG3842	ATPase activity
CYAGR_RS02870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYAGR_RS02875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYAGR_RS02905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYAGR_RS02910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYAGR_RS02935	COG0469	pyruvate kinase activity
CYAGR_RS02940	COG1136	(ABC) transporter
CYAGR_RS02940	COG0577	efflux transmembrane transporter activity
CYAGR_RS02950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYAGR_RS02955	COG0740	serine-type endopeptidase activity
CYAGR_RS02970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYAGR_RS02985	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CYAGR_RS02990	COG1175	transmembrane transport
CYAGR_RS02995	COG0514	ATP-dependent DNA helicase (RecQ)
CYAGR_RS03000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYAGR_RS03040	COG3588	fructose-bisphosphate aldolase
CYAGR_RS03045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CYAGR_RS03045	COG1793	dna ligase
CYAGR_RS03055	COG1793	dna ligase
CYAGR_RS03065	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYAGR_RS03085	COG1201	RNA secondary structure unwinding
CYAGR_RS03125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYAGR_RS03130	COG4106	trans-aconitate 2-methyltransferase activity
CYAGR_RS03135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CYAGR_RS03150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYAGR_RS03155	COG1122	ATPase activity
CYAGR_RS03175	COG1836	PFAM Integral membrane protein DUF92
CYAGR_RS03190	COG0436	Aminotransferase
CYAGR_RS03195	COG1573	uracil-dna glycosylase
CYAGR_RS03200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYAGR_RS03205	COG0793	Belongs to the peptidase S41A family
CYAGR_RS03230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYAGR_RS03240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYAGR_RS03250	COG0861	Integral membrane protein TerC family
CYAGR_RS03260	COG0513	Belongs to the DEAD box helicase family
CYAGR_RS03275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYAGR_RS03285	COG0312	modulator of DNA gyrase
CYAGR_RS03290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYAGR_RS03305	COG0163	prenyltransferase activity
CYAGR_RS03310	COG0557	exoribonuclease II activity
CYAGR_RS03320	COG2119	membrane
CYAGR_RS03330	COG0038	chloride channel
CYAGR_RS03335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYAGR_RS03335	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYAGR_RS03355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYAGR_RS03360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYAGR_RS03370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CYAGR_RS03375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYAGR_RS03385	COG0191	fructose-bisphosphate aldolase activity
CYAGR_RS03390	COG0673	inositol 2-dehydrogenase activity
CYAGR_RS03400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYAGR_RS03405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CYAGR_RS03415	COG3954	Phosphoribulokinase
CYAGR_RS03420	COG0473	3-isopropylmalate dehydrogenase activity
CYAGR_RS03425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYAGR_RS03435	COG1404	Belongs to the peptidase S8 family
CYAGR_RS03440	COG5002	protein histidine kinase activity
CYAGR_RS03440	COG5001	Diguanylate cyclase
CYAGR_RS03440	COG3447	MASE1 domain protein
CYAGR_RS03445	COG3264	Mechanosensitive ion channel
CYAGR_RS03445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYAGR_RS03470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYAGR_RS03485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYAGR_RS03500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CYAGR_RS03505	COG0114	fumarate hydratase activity
CYAGR_RS03510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYAGR_RS03515	COG2197	response regulator
CYAGR_RS03525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYAGR_RS03550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYAGR_RS03575	COG0384	phenazine biosynthesis protein PhzF
CYAGR_RS03630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CYAGR_RS03635	COG1528	Iron-storage protein
CYAGR_RS03645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYAGR_RS03670	COG0753	catalase activity
CYAGR_RS03675	COG3237	CsbD-like
CYAGR_RS03680	COG1429	ligase activity, forming nitrogen-metal bonds
CYAGR_RS03685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYAGR_RS03695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYAGR_RS03700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYAGR_RS03770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYAGR_RS03785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYAGR_RS03790	COG0149	triose-phosphate isomerase activity
CYAGR_RS03800	COG1132	(ABC) transporter
CYAGR_RS03815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYAGR_RS03825	COG0799	negative regulation of ribosome biogenesis
CYAGR_RS03845	COG0644	oxidoreductase
CYAGR_RS03870	COG0589	response to stress
CYAGR_RS03870	COG0475	glutathione-regulated potassium exporter activity
CYAGR_RS03920	COG0724	RNA recognition motif
CYAGR_RS03940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYAGR_RS03960	COG1129	ABC transporter
CYAGR_RS03960	COG0842	Transport permease protein
CYAGR_RS03985	COG2226	methyltransferase
CYAGR_RS04015	COG0415	Belongs to the DNA photolyase family
CYAGR_RS04040	COG2217	Heavy metal translocating P-type atpase
CYAGR_RS04050	COG1472	Belongs to the glycosyl hydrolase 3 family
CYAGR_RS04060	COG0463	Glycosyl transferase, family 2
CYAGR_RS04095	COG3237	CsbD-like
CYAGR_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
CYAGR_RS04135	COG3487	Iron-regulated protein
CYAGR_RS04140	COG3659	wide pore channel activity
CYAGR_RS04145	COG2197	response regulator
CYAGR_RS04165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYAGR_RS04175	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CYAGR_RS04210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CYAGR_RS04215	COG0271	Belongs to the BolA IbaG family
CYAGR_RS04230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CYAGR_RS04245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYAGR_RS04250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CYAGR_RS04255	COG1074	ATP-dependent DNA helicase activity
CYAGR_RS04260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CYAGR_RS04270	COG0513	Belongs to the DEAD box helicase family
CYAGR_RS04285	COG0724	RNA recognition motif
CYAGR_RS04290	COG1132	(ABC) transporter
CYAGR_RS04300	COG1285	pathogenesis
CYAGR_RS04330	COG3706	GGDEF domain
CYAGR_RS04360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYAGR_RS04365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYAGR_RS04390	COG1051	belongs to the nudix hydrolase family
CYAGR_RS04390	COG1056	cytidyltransferase-related domain
CYAGR_RS04400	COG1525	nuclease
CYAGR_RS04405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYAGR_RS04420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYAGR_RS04445	COG2095	MarC family integral membrane protein
CYAGR_RS04470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS04480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYAGR_RS04485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYAGR_RS04490	COG1116	anion transmembrane transporter activity
CYAGR_RS04490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYAGR_RS04495	COG1116	anion transmembrane transporter activity
CYAGR_RS04540	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYAGR_RS04560	COG0739	heme binding
CYAGR_RS04560	COG1196	nuclear chromosome segregation
CYAGR_RS04560	COG0741	lytic transglycosylase activity
CYAGR_RS04605	COG0561	phosphatase activity
CYAGR_RS04605	COG3100	YcgL domain-containing protein
CYAGR_RS04610	COG0438	transferase activity, transferring glycosyl groups
CYAGR_RS04650	COG2326	polyphosphate kinase activity
CYAGR_RS04665	COG0010	Belongs to the arginase family
CYAGR_RS04670	COG0375	protein maturation
CYAGR_RS04690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYAGR_RS04695	COG1116	anion transmembrane transporter activity
CYAGR_RS04720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYAGR_RS04735	COG1733	regulation of RNA biosynthetic process
CYAGR_RS04740	COG1902	pentaerythritol trinitrate reductase activity
CYAGR_RS04750	COG1741	Belongs to the pirin family
CYAGR_RS04810	COG0004	ammonium transporteR
CYAGR_RS04815	COG0347	Belongs to the P(II) protein family
CYAGR_RS04825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYAGR_RS04840	COG0039	L-malate dehydrogenase activity
CYAGR_RS04865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYAGR_RS04870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS04880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYAGR_RS04885	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYAGR_RS04890	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CYAGR_RS04895	COG0640	Transcriptional regulator
CYAGR_RS04905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYAGR_RS04910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYAGR_RS04920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYAGR_RS04925	COG0811	peptide transport
CYAGR_RS04950	COG5002	protein histidine kinase activity
CYAGR_RS04955	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS04960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS04970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYAGR_RS04975	COG0598	Magnesium transport protein CorA
CYAGR_RS04995	COG0058	SHG alpha-glucan phosphorylase activity
CYAGR_RS05005	COG0446	pyridine nucleotide-disulphide oxidoreductase
CYAGR_RS05020	COG4208	sulfate ABC transporter
CYAGR_RS05025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CYAGR_RS05030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYAGR_RS05040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS05045	COG1959	2 iron, 2 sulfur cluster binding
CYAGR_RS05050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYAGR_RS05055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYAGR_RS05060	COG0121	glutamine amidotransferase
CYAGR_RS05075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYAGR_RS05095	COG0277	FAD linked oxidase domain protein
CYAGR_RS05100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYAGR_RS05130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS05140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYAGR_RS05145	COG1121	(ABC) transporter
CYAGR_RS05160	COG0523	cobalamin synthesis protein
CYAGR_RS05165	COG1252	NADH dehydrogenase
CYAGR_RS05185	COG0405	Gamma-glutamyltransferase
CYAGR_RS05205	COG1666	GTP binding
CYAGR_RS05215	COG0330	HflC and HflK could
CYAGR_RS05230	COG0857	belongs to the CobB CobQ family
CYAGR_RS05235	COG0300	oxidoreductase activity
CYAGR_RS05235	COG3000	fatty acid hydroxylase
CYAGR_RS05240	COG0024	Methionine aminopeptidase
CYAGR_RS05250	COG0335	large ribosomal subunit rRNA binding
CYAGR_RS05270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYAGR_RS05285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYAGR_RS05285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYAGR_RS05300	COG0215	cysteine-tRNA ligase activity
CYAGR_RS05315	COG1598	PFAM Uncharacterised protein family UPF0150
CYAGR_RS05380	COG0438	transferase activity, transferring glycosyl groups
CYAGR_RS05380	COG1216	Glycosyl transferase, family 2
CYAGR_RS05410	COG0438	transferase activity, transferring glycosyl groups
CYAGR_RS05440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYAGR_RS05460	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CYAGR_RS05480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYAGR_RS05515	COG0440	acetolactate synthase activity
CYAGR_RS05520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYAGR_RS05545	COG0424	maF-like protein
CYAGR_RS05555	COG1492	cobalamin metabolic process
CYAGR_RS05575	COG0562	UDP-galactopyranose mutase
CYAGR_RS05580	COG0482	sulfurtransferase activity
CYAGR_RS05585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYAGR_RS05585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYAGR_RS05590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS05600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYAGR_RS05610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYAGR_RS05615	COG0228	four-way junction DNA binding
CYAGR_RS05620	COG1702	phosphate starvation-inducible protein PhoH
CYAGR_RS05630	COG0670	Belongs to the BI1 family
CYAGR_RS05635	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CYAGR_RS05640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYAGR_RS05645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYAGR_RS05655	COG1132	(ABC) transporter
CYAGR_RS05660	COG1442	glycosyl transferase family 8
CYAGR_RS05720	COG0438	transferase activity, transferring glycosyl groups
CYAGR_RS05735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYAGR_RS05750	COG2192	nodulation
CYAGR_RS05770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYAGR_RS05825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYAGR_RS05835	COG0336	Belongs to the RNA methyltransferase TrmD family
CYAGR_RS05840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYAGR_RS05850	COG1691	(AIR) carboxylase
CYAGR_RS05870	COG0196	riboflavin kinase activity
CYAGR_RS05880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYAGR_RS05885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYAGR_RS05890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYAGR_RS05915	COG2755	lipolytic protein G-D-S-L family
CYAGR_RS05915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYAGR_RS05930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYAGR_RS05930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYAGR_RS05950	COG2135	peptidase activity
CYAGR_RS05955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYAGR_RS05965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYAGR_RS05970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYAGR_RS05990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYAGR_RS06035	COG3119	arylsulfatase activity
CYAGR_RS06040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CYAGR_RS06060	COG3264	Mechanosensitive ion channel
CYAGR_RS06060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYAGR_RS06070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYAGR_RS06085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYAGR_RS06090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYAGR_RS06105	COG1022	Amp-dependent synthetase and ligase
CYAGR_RS06110	COG0321	lipoyl(octanoyl) transferase activity
CYAGR_RS06115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYAGR_RS06120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CYAGR_RS06135	COG0438	transferase activity, transferring glycosyl groups
CYAGR_RS06140	COG2201	protein-glutamate methylesterase activity
CYAGR_RS06145	COG5002	protein histidine kinase activity
CYAGR_RS06160	COG0697	spore germination
CYAGR_RS06165	COG0616	signal peptide processing
CYAGR_RS06180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CYAGR_RS06185	COG0594	ribonuclease P activity
CYAGR_RS06195	COG0706	membrane insertase activity
CYAGR_RS06205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYAGR_RS06235	COG1104	cysteine desulfurase activity
CYAGR_RS06240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CYAGR_RS06250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYAGR_RS06260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYAGR_RS06265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYAGR_RS06280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYAGR_RS06290	COG0577	efflux transmembrane transporter activity
CYAGR_RS06290	COG1136	(ABC) transporter
CYAGR_RS06295	COG0134	indole-3-glycerol-phosphate synthase activity
CYAGR_RS06300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYAGR_RS06305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYAGR_RS06320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYAGR_RS06325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYAGR_RS06330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYAGR_RS06335	COG0285	dihydrofolate synthase activity
CYAGR_RS06345	COG0277	FAD linked oxidase domain protein
CYAGR_RS06370	COG4948	Mandelate Racemase Muconate Lactonizing
CYAGR_RS06375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYAGR_RS06380	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYAGR_RS06395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYAGR_RS06400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYAGR_RS06405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYAGR_RS06410	COG4956	integral membrane protein (PIN domain superfamily)
CYAGR_RS06415	COG0740	serine-type endopeptidase activity
CYAGR_RS06420	COG0740	serine-type endopeptidase activity
CYAGR_RS06425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYAGR_RS06435	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CYAGR_RS06440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYAGR_RS06465	COG0668	transmembrane transport
CYAGR_RS06485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CYAGR_RS06490	COG3119	arylsulfatase activity
CYAGR_RS06510	COG0752	glycyl-tRNA synthetase alpha subunit
CYAGR_RS06515	COG2226	methyltransferase
CYAGR_RS06525	COG0107	imidazoleglycerol-phosphate synthase activity
CYAGR_RS06535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYAGR_RS06540	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYAGR_RS06545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYAGR_RS06545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYAGR_RS06565	COG0189	ligase activity
CYAGR_RS06570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYAGR_RS06585	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS06590	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS06680	COG0481	GTPase activity
CYAGR_RS06690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CYAGR_RS06700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYAGR_RS06710	COG0750	zinc metalloprotease
CYAGR_RS06715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYAGR_RS06720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYAGR_RS06725	COG1185	polyribonucleotide nucleotidyltransferase activity
CYAGR_RS06730	COG4118	positive regulation of growth
CYAGR_RS06740	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYAGR_RS06745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CYAGR_RS06780	COG0640	Transcriptional regulator
CYAGR_RS06785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYAGR_RS06800	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYAGR_RS06840	COG2988	succinylglutamate desuccinylase activity
CYAGR_RS06855	COG0488	(ABC) transporter
CYAGR_RS06870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYAGR_RS06880	COG1193	negative regulation of DNA recombination
CYAGR_RS06890	COG0113	porphobilinogen synthase activity
CYAGR_RS06900	COG0484	heat shock protein binding
CYAGR_RS06940	COG0116	Belongs to the methyltransferase superfamily
CYAGR_RS06955	COG4935	Belongs to the peptidase S8 family
CYAGR_RS06955	COG1404	Belongs to the peptidase S8 family
CYAGR_RS06970	COG1196	nuclear chromosome segregation
CYAGR_RS06980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYAGR_RS06985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYAGR_RS06995	COG0439	Biotin carboxylase
CYAGR_RS07010	COG0515	serine threonine protein kinase
CYAGR_RS07030	COG4178	(ABC) transporter
CYAGR_RS07035	COG0537	adenosine 5'-monophosphoramidase activity
CYAGR_RS07045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYAGR_RS07060	COG0242	peptide deformylase activity
CYAGR_RS07095	COG3347	Dehydrogenase
CYAGR_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
CYAGR_RS07105	COG0604	alcohol dehydrogenase
CYAGR_RS07110	COG2226	methyltransferase
CYAGR_RS07120	COG2897	thiosulfate sulfurtransferase activity
CYAGR_RS07135	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CYAGR_RS07140	COG0154	amidase activity
CYAGR_RS07145	COG0025	NhaP-type Na H and K H
CYAGR_RS07175	COG4335	DNA alkylation repair
CYAGR_RS07200	COG4974	Belongs to the 'phage' integrase family
CYAGR_RS07210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYAGR_RS07215	COG0719	Fe-S assembly protein
CYAGR_RS07220	COG0396	ATPase activity
CYAGR_RS07225	COG0719	Fe-S assembly protein
CYAGR_RS07230	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CYAGR_RS07255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYAGR_RS07270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYAGR_RS07300	COG0033	Phosphoglucomutase
CYAGR_RS07305	COG3659	wide pore channel activity
CYAGR_RS07310	COG0786	glutamate:sodium symporter activity
CYAGR_RS07320	COG2066	Belongs to the glutaminase family
CYAGR_RS07355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYAGR_RS07375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYAGR_RS07380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CYAGR_RS07385	COG0175	sulfate reduction
CYAGR_RS07390	COG1252	NADH dehydrogenase
CYAGR_RS07395	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CYAGR_RS07400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYAGR_RS07405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYAGR_RS07410	COG0569	domain protein
CYAGR_RS07415	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CYAGR_RS07435	COG0488	(ABC) transporter
CYAGR_RS07445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYAGR_RS07460	COG1643	Atp-dependent helicase
CYAGR_RS07480	COG1570	exodeoxyribonuclease VII activity
CYAGR_RS07535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYAGR_RS07540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYAGR_RS07545	COG0793	Belongs to the peptidase S41A family
CYAGR_RS07550	COG1078	dGTPase activity
CYAGR_RS07555	COG0850	regulation of cytokinetic process
CYAGR_RS07575	COG2894	cell division
CYAGR_RS07580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CYAGR_RS07600	COG2119	membrane
CYAGR_RS07605	COG0009	L-threonylcarbamoyladenylate synthase
CYAGR_RS07610	COG2890	protein-(glutamine-N5) methyltransferase activity
CYAGR_RS07615	COG0758	DNA mediated transformation
CYAGR_RS07625	COG0589	response to stress
CYAGR_RS07650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYAGR_RS07655	COG0539	negative regulation of cytoplasmic translation
CYAGR_RS07660	COG0546	phosphoglycolate phosphatase activity
CYAGR_RS07665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYAGR_RS07730	COG1413	lyase activity
CYAGR_RS07735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYAGR_RS07740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYAGR_RS07740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYAGR_RS07745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYAGR_RS07750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYAGR_RS07760	COG0667	Aldo Keto reductase
CYAGR_RS07815	COG0408	coproporphyrinogen oxidase activity
CYAGR_RS07820	COG0489	protein tyrosine kinase activity
CYAGR_RS07825	COG0772	Belongs to the SEDS family
CYAGR_RS07840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYAGR_RS07845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYAGR_RS07850	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYAGR_RS07865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYAGR_RS07870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CYAGR_RS07875	COG1606	tRNA processing
CYAGR_RS07880	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CYAGR_RS07905	COG3001	Fructosamine kinase
CYAGR_RS07930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYAGR_RS07945	COG1122	ATPase activity
CYAGR_RS07950	COG4067	protein conserved in archaea
CYAGR_RS07950	COG0189	ligase activity
CYAGR_RS07980	COG0798	PFAM Bile acid sodium symporter
CYAGR_RS07985	COG0730	response to heat
CYAGR_RS07990	COG0484	heat shock protein binding
CYAGR_RS08075	COG1487	ribonuclease activity
CYAGR_RS08105	COG3046	protein related to deoxyribodipyrimidine photolyase
CYAGR_RS08110	COG0415	Belongs to the DNA photolyase family
CYAGR_RS08115	COG3384	dioxygenase
CYAGR_RS08120	COG2319	Wd-40 repeat
CYAGR_RS08140	COG0475	glutathione-regulated potassium exporter activity
CYAGR_RS08180	COG1064	alcohol dehydrogenase
CYAGR_RS08190	COG0318	PFAM AMP-dependent synthetase and ligase
CYAGR_RS08200	COG2337	Toxic component of a toxin-antitoxin (TA) module
CYAGR_RS08330	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CYAGR_RS08350	COG0556	nucleotide-excision repair
CYAGR_RS08370	COG1487	ribonuclease activity
CYAGR_RS08410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYAGR_RS08425	COG1695	Transcriptional regulator
CYAGR_RS08470	COG0598	Magnesium transport protein CorA
CYAGR_RS08495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYAGR_RS08510	COG3854	ATPases associated with a variety of cellular activities
CYAGR_RS08530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYAGR_RS08535	COG0088	Forms part of the polypeptide exit tunnel
CYAGR_RS08540	COG0089	rRNA binding
CYAGR_RS08545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYAGR_RS08550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYAGR_RS08555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYAGR_RS08560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYAGR_RS08570	COG0255	Belongs to the universal ribosomal protein uL29 family
CYAGR_RS08575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYAGR_RS08580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CYAGR_RS08585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYAGR_RS08590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYAGR_RS08595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYAGR_RS08600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYAGR_RS08605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYAGR_RS08610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYAGR_RS08615	COG0200	Binds to the 23S rRNA
CYAGR_RS08620	COG0201	protein transport
CYAGR_RS08625	COG0563	adenylate kinase activity
CYAGR_RS08630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYAGR_RS08635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYAGR_RS08640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYAGR_RS08645	COG0202	RNA polymerase activity
CYAGR_RS08655	COG0101	tRNA pseudouridine synthase activity
CYAGR_RS08660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYAGR_RS08665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYAGR_RS08670	COG0254	rRNA binding
CYAGR_RS08675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYAGR_RS08685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYAGR_RS08705	COG0463	Glycosyl transferase, family 2
CYAGR_RS08735	COG2885	chlorophyll binding
CYAGR_RS08740	COG2885	chlorophyll binding
CYAGR_RS08760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYAGR_RS08770	COG0067	glutamate synthase
CYAGR_RS08770	COG0069	glutamate synthase activity
CYAGR_RS08770	COG0070	glutamate synthase
CYAGR_RS08785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYAGR_RS08790	COG0049	tRNA binding
CYAGR_RS08795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYAGR_RS08800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYAGR_RS08805	COG0051	transcription antitermination factor activity, RNA binding
CYAGR_RS08810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYAGR_RS08815	COG2226	methyltransferase
CYAGR_RS08820	COG0077	Prephenate dehydratase
CYAGR_RS08820	COG1605	Chorismate mutase
CYAGR_RS08830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYAGR_RS08835	COG1530	ribonuclease E activity
CYAGR_RS08845	COG0436	Aminotransferase
CYAGR_RS08850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYAGR_RS08865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYAGR_RS08875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYAGR_RS08885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYAGR_RS08890	COG0529	Catalyzes the synthesis of activated sulfate
CYAGR_RS08890	COG2046	Belongs to the sulfate adenylyltransferase family
CYAGR_RS08905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYAGR_RS08910	COG3536	Protein conserved in bacteria
CYAGR_RS08935	COG0540	Belongs to the ATCase OTCase family
CYAGR_RS08940	COG2094	Belongs to the DNA glycosylase MPG family
CYAGR_RS08960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYAGR_RS08985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYAGR_RS09005	COG0069	glutamate synthase activity
CYAGR_RS09040	COG2801	Transposase and inactivated derivatives
CYAGR_RS09075	COG4227	nucleotidyltransferase activity
CYAGR_RS09085	COG2801	Transposase and inactivated derivatives
CYAGR_RS09095	COG1525	nuclease
CYAGR_RS09135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CYAGR_RS09140	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CYAGR_RS09175	COG0656	L-ascorbic acid biosynthetic process
CYAGR_RS09215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYAGR_RS09240	COG2072	flavoprotein involved in K transport
CYAGR_RS09265	COG2144	transferase activity, transferring acyl groups
CYAGR_RS09285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS09295	COG2323	membrane
CYAGR_RS09380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYAGR_RS09390	COG0420	3'-5' exonuclease activity
CYAGR_RS09395	COG0419	ATPase involved in DNA repair
CYAGR_RS09395	COG0419	ATPase involved in DNA repair
CYAGR_RS09425	COG0651	ATP synthesis coupled electron transport
CYAGR_RS09445	COG0412	Dienelactone hydrolase
CYAGR_RS09455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYAGR_RS09465	COG0741	lytic transglycosylase activity
CYAGR_RS09480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYAGR_RS09505	COG2197	response regulator
CYAGR_RS09540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYAGR_RS09545	COG1136	(ABC) transporter
CYAGR_RS09545	COG0577	efflux transmembrane transporter activity
CYAGR_RS09550	COG1136	(ABC) transporter
CYAGR_RS09555	COG0456	acetyltransferase
CYAGR_RS09565	COG1136	(ABC) transporter
CYAGR_RS09565	COG0577	efflux transmembrane transporter activity
CYAGR_RS09600	COG2814	Major facilitator Superfamily
CYAGR_RS09635	COG2801	Transposase and inactivated derivatives
CYAGR_RS09655	COG4974	Belongs to the 'phage' integrase family
CYAGR_RS09660	COG0717	Belongs to the dCTP deaminase family
CYAGR_RS09670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYAGR_RS09675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS09680	COG4372	Transposase
CYAGR_RS09695	COG0193	aminoacyl-tRNA hydrolase activity
CYAGR_RS09700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYAGR_RS09730	COG0066	3-isopropylmalate dehydratase activity
CYAGR_RS09735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYAGR_RS09745	COG1058	Belongs to the CinA family
CYAGR_RS09745	COG1546	Belongs to the CinA family
CYAGR_RS09750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYAGR_RS09755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYAGR_RS09780	COG0728	peptidoglycan biosynthetic process
CYAGR_RS09785	COG1489	DNA binding
CYAGR_RS09795	COG0004	ammonium transporteR
CYAGR_RS09800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYAGR_RS09815	COG0138	bifunctional purine biosynthesis protein purh
CYAGR_RS09830	COG2205	protein histidine kinase activity
CYAGR_RS09840	COG0343	queuine tRNA-ribosyltransferase activity
CYAGR_RS09860	COG0673	inositol 2-dehydrogenase activity
CYAGR_RS09865	COG1253	flavin adenine dinucleotide binding
CYAGR_RS09875	COG3128	pkhd-type hydroxylase
CYAGR_RS09885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYAGR_RS09890	COG0354	folic acid binding
CYAGR_RS09900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYAGR_RS09905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYAGR_RS09930	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CYAGR_RS09935	COG0131	Imidazoleglycerol-phosphate dehydratase
CYAGR_RS09950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYAGR_RS09975	COG0415	Belongs to the DNA photolyase family
CYAGR_RS09980	COG0494	nUDIX hydrolase
CYAGR_RS09985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYAGR_RS09995	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYAGR_RS09995	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYAGR_RS10005	COG3842	ATPase activity
CYAGR_RS10010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYAGR_RS10015	COG2801	Transposase and inactivated derivatives
CYAGR_RS10030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS10040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS10045	COG1773	rubredoxin
CYAGR_RS10050	COG4447	cellulose binding
CYAGR_RS10075	COG0124	histidyl-tRNA synthetase
CYAGR_RS10085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYAGR_RS10090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYAGR_RS10095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYAGR_RS10105	COG0617	tRNA 3'-terminal CCA addition
CYAGR_RS10110	COG3754	Rhamnan synthesis protein F
CYAGR_RS10130	COG1132	(ABC) transporter
CYAGR_RS10140	COG5398	heme oxygenase
CYAGR_RS10150	COG0538	isocitrate dehydrogenase activity
CYAGR_RS10155	COG0247	lactate metabolic process
CYAGR_RS10165	COG0277	FAD linked oxidase domain protein
CYAGR_RS10175	COG2755	lipolytic protein G-D-S-L family
CYAGR_RS10175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYAGR_RS10180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYAGR_RS10180	COG2755	lipolytic protein G-D-S-L family
CYAGR_RS10185	COG2755	lipolytic protein G-D-S-L family
CYAGR_RS10185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYAGR_RS10200	COG0475	glutathione-regulated potassium exporter activity
CYAGR_RS10205	COG0058	SHG alpha-glucan phosphorylase activity
CYAGR_RS10230	COG0571	ribonuclease III activity
CYAGR_RS10240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYAGR_RS10250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYAGR_RS10255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS10260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYAGR_RS10265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYAGR_RS10270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CYAGR_RS10275	COG0463	Glycosyl transferase, family 2
CYAGR_RS10290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYAGR_RS10315	COG0484	heat shock protein binding
CYAGR_RS10340	COG2391	methyltransferase activity
CYAGR_RS10345	COG2391	methyltransferase activity
CYAGR_RS10350	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CYAGR_RS10365	COG1473	amidohydrolase
CYAGR_RS10380	COG2255	four-way junction helicase activity
CYAGR_RS10385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYAGR_RS10390	COG0515	serine threonine protein kinase
CYAGR_RS10390	COG1357	PFAM Pentapeptide repeats (8 copies)
CYAGR_RS10405	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CYAGR_RS10430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYAGR_RS10435	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS10460	COG0629	single-stranded DNA binding
CYAGR_RS10465	COG0586	Pfam SNARE associated Golgi protein
CYAGR_RS10490	COG0802	atpase or kinase
CYAGR_RS10500	COG1960	acyl-CoA dehydrogenase activity
CYAGR_RS10505	COG4974	Belongs to the 'phage' integrase family
CYAGR_RS10520	COG1733	regulation of RNA biosynthetic process
CYAGR_RS10525	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CYAGR_RS10535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS10540	COG2239	Acts as a magnesium transporter
CYAGR_RS10545	COG0386	Belongs to the glutathione peroxidase family
CYAGR_RS10555	COG1372	Participates in initiation and elongation during chromosome replication
CYAGR_RS10555	COG0187	DNA topoisomerase II activity
CYAGR_RS10560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYAGR_RS10565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYAGR_RS10570	COG0412	Dienelactone hydrolase
CYAGR_RS10575	COG1725	Transcriptional regulator
CYAGR_RS10580	COG1045	serine acetyltransferase
CYAGR_RS10585	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CYAGR_RS10595	COG0653	protein targeting
CYAGR_RS10610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYAGR_RS10615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYAGR_RS10640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYAGR_RS10645	COG1215	transferase activity, transferring glycosyl groups
CYAGR_RS10695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CYAGR_RS10700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYAGR_RS10705	COG2082	Precorrin-8x methylmutase
CYAGR_RS10730	COG2133	pyrroloquinoline quinone binding
CYAGR_RS10735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CYAGR_RS10740	COG1970	mechanosensitive ion channel activity
CYAGR_RS10745	COG0556	nucleotide-excision repair
CYAGR_RS10760	COG0037	tRNA processing
CYAGR_RS10770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CYAGR_RS10775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYAGR_RS10780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYAGR_RS10785	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYAGR_RS10790	COG0740	serine-type endopeptidase activity
CYAGR_RS10795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYAGR_RS10805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYAGR_RS10810	COG1215	transferase activity, transferring glycosyl groups
CYAGR_RS10815	COG2385	sporulation resulting in formation of a cellular spore
CYAGR_RS10820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYAGR_RS10825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYAGR_RS10840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYAGR_RS10840	COG2022	thiamine diphosphate biosynthetic process
CYAGR_RS10860	COG0768	penicillin binding
CYAGR_RS10875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYAGR_RS10875	COG0519	Catalyzes the synthesis of GMP from XMP
CYAGR_RS10880	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CYAGR_RS10945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CYAGR_RS10950	COG0511	ligase activity, forming carbon-carbon bonds
CYAGR_RS10955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYAGR_RS10960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYAGR_RS10965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYAGR_RS10970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYAGR_RS10975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYAGR_RS10980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYAGR_RS10985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYAGR_RS10990	COG1162	GTPase activity
CYAGR_RS11000	COG0484	heat shock protein binding
CYAGR_RS11005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYAGR_RS11025	COG2081	HI0933 family
CYAGR_RS11030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYAGR_RS11035	COG0724	RNA recognition motif
CYAGR_RS11040	COG0165	Argininosuccinate lyase
CYAGR_RS11045	COG2208	phosphoserine phosphatase activity
CYAGR_RS11050	COG0552	protein localization to endoplasmic reticulum
CYAGR_RS11055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYAGR_RS11070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYAGR_RS11080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYAGR_RS11085	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYAGR_RS11120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CYAGR_RS11210	COG4974	Belongs to the 'phage' integrase family
CYAGR_RS11225	COG3744	PilT protein domain protein
CYAGR_RS11240	COG0438	transferase activity, transferring glycosyl groups
CYAGR_RS11245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYAGR_RS11260	COG0592	DNA-directed DNA polymerase activity
CYAGR_RS11265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYAGR_RS11275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYAGR_RS11290	COG0076	glutamate decarboxylase activity
CYAGR_RS11300	COG4221	oxidoreductase activity
CYAGR_RS11305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYAGR_RS11320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CYAGR_RS11335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYAGR_RS11350	COG0137	argininosuccinate synthase activity
CYAGR_RS11360	COG0360	Binds together with S18 to 16S ribosomal RNA
CYAGR_RS11370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYAGR_RS11375	COG0443	Heat shock 70 kDa protein
CYAGR_RS11390	COG0788	formyltetrahydrofolate deformylase activity
CYAGR_RS11425	COG1049	propionate catabolic process, 2-methylcitrate cycle
CYAGR_RS11430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYAGR_RS11445	COG0170	dolichyl monophosphate biosynthetic process
CYAGR_RS11450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS11455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYAGR_RS11475	COG1053	succinate dehydrogenase
CYAGR_RS11490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CYAGR_RS11495	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CYAGR_RS11505	COG0243	molybdopterin cofactor binding
CYAGR_RS11510	COG1116	anion transmembrane transporter activity
CYAGR_RS11515	COG1116	anion transmembrane transporter activity
CYAGR_RS11515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYAGR_RS11520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYAGR_RS11525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYAGR_RS11530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYAGR_RS11535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYAGR_RS11570	COG0519	Catalyzes the synthesis of GMP from XMP
CYAGR_RS11570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYAGR_RS11575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYAGR_RS11585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYAGR_RS11590	COG0315	cyclic pyranopterin monophosphate synthase activity
CYAGR_RS11595	COG0303	'Molybdopterin
CYAGR_RS11605	COG0314	molybdopterin synthase activity
CYAGR_RS11625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CYAGR_RS11685	COG2197	response regulator
CYAGR_RS11790	COG2226	methyltransferase
CYAGR_RS11795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYAGR_RS11820	COG0475	glutathione-regulated potassium exporter activity
CYAGR_RS11825	COG0347	Belongs to the P(II) protein family
CYAGR_RS11835	COG3956	TIGRFAM MazG family protein
CYAGR_RS11840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYAGR_RS11850	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYAGR_RS11855	COG0010	Belongs to the arginase family
CYAGR_RS11870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYAGR_RS11875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYAGR_RS11885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS11890	COG0783	Belongs to the Dps family
CYAGR_RS11900	COG0602	queuosine metabolic process
CYAGR_RS11905	COG4574	serine-type endopeptidase inhibitor activity
CYAGR_RS11910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CYAGR_RS11965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYAGR_RS11985	COG0830	nickel cation binding
CYAGR_RS11990	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CYAGR_RS11995	COG0829	nickel cation binding
CYAGR_RS12005	COG0730	response to heat
CYAGR_RS12010	COG1704	LemA family
CYAGR_RS12025	COG0831	urea catabolic process
CYAGR_RS12030	COG0832	Belongs to the urease beta subunit family
CYAGR_RS12035	COG0804	urea catabolic process
CYAGR_RS12055	COG2308	Evidence 4 Homologs of previously reported genes of
CYAGR_RS12070	COG0058	SHG alpha-glucan phosphorylase activity
CYAGR_RS12080	COG5001	Diguanylate cyclase
CYAGR_RS12100	COG0746	molybdenum cofactor guanylyltransferase activity
CYAGR_RS12105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYAGR_RS12150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CYAGR_RS12180	COG0709	Synthesizes selenophosphate from selenide and ATP
CYAGR_RS12190	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CYAGR_RS12195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYAGR_RS12205	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYAGR_RS12235	COG3237	CsbD-like
CYAGR_RS12255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CYAGR_RS12265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CYAGR_RS12265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYAGR_RS12270	COG3639	organic phosphonate transmembrane transporter activity
CYAGR_RS12290	COG0590	tRNA wobble adenosine to inosine editing
CYAGR_RS12300	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYAGR_RS12325	COG1597	lipid kinase activity
CYAGR_RS12325	COG1803	Methylglyoxal synthase
CYAGR_RS12375	COG2801	Transposase and inactivated derivatives
CYAGR_RS12400	COG2801	Transposase and inactivated derivatives
CYAGR_RS12410	COG5001	Diguanylate cyclase
CYAGR_RS12410	COG5002	protein histidine kinase activity
CYAGR_RS12425	COG4221	oxidoreductase activity
CYAGR_RS12470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYAGR_RS12485	COG1595	DNA-templated transcription, initiation
CYAGR_RS12500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYAGR_RS12515	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYAGR_RS12515	COG3264	Mechanosensitive ion channel
CYAGR_RS12585	COG0525	valine-tRNA ligase activity
CYAGR_RS12600	COG0398	Pfam SNARE associated Golgi protein
CYAGR_RS12615	COG2274	protein secretion by the type I secretion system
CYAGR_RS12640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYAGR_RS12680	COG0445	tRNA wobble uridine modification
CYAGR_RS12685	COG1335	isochorismatase
CYAGR_RS12700	COG1372	Participates in initiation and elongation during chromosome replication
CYAGR_RS12700	COG0305	Participates in initiation and elongation during chromosome replication
CYAGR_RS12700	COG1372	Participates in initiation and elongation during chromosome replication
CYAGR_RS12700	COG0305	Participates in initiation and elongation during chromosome replication
CYAGR_RS12705	COG0359	binds to the 23S rRNA
CYAGR_RS12725	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CYAGR_RS12730	COG0509	glycine decarboxylation via glycine cleavage system
CYAGR_RS12750	COG0426	domain, Protein
CYAGR_RS12750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYAGR_RS12760	COG0071	Belongs to the small heat shock protein (HSP20) family
CYAGR_RS12775	COG3239	Fatty acid desaturase
CYAGR_RS12780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYAGR_RS12790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CYAGR_RS12795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYAGR_RS12825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS12850	COG1166	arginine decarboxylase activity
CYAGR_RS12855	COG0105	UTP biosynthetic process
CYAGR_RS12865	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CYAGR_RS12870	COG2022	thiamine diphosphate biosynthetic process
CYAGR_RS12870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYAGR_RS12875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYAGR_RS12880	COG0237	dephospho-CoA kinase activity
CYAGR_RS12885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYAGR_RS12900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYAGR_RS12905	COG0148	phosphopyruvate hydratase activity
CYAGR_RS12910	COG0346	lactoylglutathione lyase activity
CYAGR_RS12915	COG0542	response to heat
CYAGR_RS12920	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYAGR_RS12925	COG0250	Participates in transcription elongation, termination and antitermination
CYAGR_RS12930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYAGR_RS12935	COG0081	regulation of translation
CYAGR_RS12945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYAGR_RS12950	COG0222	ribosome binding
CYAGR_RS12960	COG0328	RNA-DNA hybrid ribonuclease activity
CYAGR_RS12965	COG0167	dihydroorotate dehydrogenase activity
CYAGR_RS12990	COG1450	Type ii and iii secretion system protein
CYAGR_RS13010	COG0714	Associated with various cellular activities
CYAGR_RS13015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYAGR_RS13020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYAGR_RS13045	COG0126	phosphoglycerate kinase activity
CYAGR_RS13050	COG0589	response to stress
CYAGR_RS13060	COG0564	pseudouridine synthase activity
CYAGR_RS13110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYAGR_RS13115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYAGR_RS13130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYAGR_RS13165	COG4172	Belongs to the ABC transporter superfamily
CYAGR_RS13170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYAGR_RS13180	COG0438	transferase activity, transferring glycosyl groups
CYAGR_RS13185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CYAGR_RS13205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYAGR_RS13215	COG0157	Belongs to the NadC ModD family
CYAGR_RS13230	COG0641	radical SAM
CYAGR_RS13245	COG0018	arginyl-trna synthetase
CYAGR_RS13265	COG3268	Saccharopine dehydrogenase
CYAGR_RS13270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CYAGR_RS13270	COG1672	PFAM Archaeal ATPase
CYAGR_RS13275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYAGR_RS13290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CYAGR_RS13295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYAGR_RS13305	COG0512	Glutamine amidotransferase of anthranilate synthase
CYAGR_RS13310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CYAGR_RS13315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYAGR_RS13325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYAGR_RS13340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYAGR_RS13345	COG0189	ligase activity
CYAGR_RS13355	COG1575	Belongs to the MenA family. Type 1 subfamily
CYAGR_RS13380	COG0824	Thioesterase
CYAGR_RS13400	COG0649	NAD binding
CYAGR_RS13405	COG0275	rRNA processing
CYAGR_RS13430	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS13435	COG0564	pseudouridine synthase activity
CYAGR_RS13440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYAGR_RS13450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYAGR_RS13455	COG0628	permease
CYAGR_RS13460	COG0529	Catalyzes the synthesis of activated sulfate
CYAGR_RS13475	COG0133	tryptophan synthase activity
CYAGR_RS13485	COG1420	regulation of RNA biosynthetic process
CYAGR_RS13490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYAGR_RS13500	COG2062	phosphohistidine phosphatase, SixA
CYAGR_RS13505	COG0372	Belongs to the citrate synthase family
CYAGR_RS13510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CYAGR_RS13515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS13520	COG0839	Belongs to the complex I subunit 6 family
CYAGR_RS13530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYAGR_RS13550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYAGR_RS13565	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYAGR_RS13570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYAGR_RS13580	COG0583	DNA-binding transcription factor activity
CYAGR_RS13595	COG0493	'glutamate synthase
CYAGR_RS13595	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYAGR_RS13600	COG1562	ergosterol biosynthetic process
CYAGR_RS13630	COG1136	(ABC) transporter
CYAGR_RS13675	COG0724	RNA recognition motif
CYAGR_RS13680	COG0617	tRNA 3'-terminal CCA addition
CYAGR_RS13690	COG1214	PFAM Peptidase M22, glycoprotease
CYAGR_RS13705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYAGR_RS13710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYAGR_RS13715	COG0416	fatty acid biosynthetic process
CYAGR_RS13720	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS13725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYAGR_RS13730	COG3063	Type IV pilus biogenesis stability protein PilW
CYAGR_RS13735	COG2217	Heavy metal translocating P-type atpase
CYAGR_RS13740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYAGR_RS13745	COG0470	DNA polymerase III
CYAGR_RS13760	COG1122	ATPase activity
CYAGR_RS13775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYAGR_RS13775	COG2755	lipolytic protein G-D-S-L family
CYAGR_RS13785	COG0463	Glycosyl transferase, family 2
CYAGR_RS13800	COG3659	wide pore channel activity
CYAGR_RS13805	COG3659	wide pore channel activity
CYAGR_RS13810	COG3659	wide pore channel activity
CYAGR_RS13815	COG3659	wide pore channel activity
CYAGR_RS13830	COG1090	epimerase
CYAGR_RS13850	COG0316	Belongs to the HesB IscA family
CYAGR_RS13855	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYAGR_RS13870	COG1587	Uroporphyrinogen-III synthase
CYAGR_RS13875	COG0463	Glycosyl transferase, family 2
CYAGR_RS13875	COG0457	Tetratricopeptide repeat
CYAGR_RS13880	COG1472	Belongs to the glycosyl hydrolase 3 family
CYAGR_RS13885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYAGR_RS13905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYAGR_RS13935	COG1032	radical SAM domain protein
CYAGR_RS13950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYAGR_RS13955	COG4243	Vitamin k epoxide reductase
CYAGR_RS13960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CYAGR_RS13965	COG1555	photosystem II stabilization
CYAGR_RS14025	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CYAGR_RS14030	COG0235	Class ii aldolase
CYAGR_RS14035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYAGR_RS14055	COG1652	LysM domain
CYAGR_RS14055	COG2823	Periplasmic or secreted lipoprotein
CYAGR_RS14060	COG1012	belongs to the aldehyde dehydrogenase family
CYAGR_RS14085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYAGR_RS14095	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CYAGR_RS14110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYAGR_RS14120	COG1160	GTP binding
CYAGR_RS14125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CYAGR_RS14135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYAGR_RS14140	COG1799	cell septum assembly
CYAGR_RS14145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYAGR_RS14150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CYAGR_RS14165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYAGR_RS14170	COG2211	Major facilitator Superfamily
CYAGR_RS14190	COG0776	regulation of translation
CYAGR_RS14195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYAGR_RS14235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYAGR_RS14235	COG3266	domain, Protein
CYAGR_RS14240	COG0195	Participates in both transcription termination and antitermination
CYAGR_RS14245	COG0779	Required for maturation of 30S ribosomal subunits
CYAGR_RS14255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYAGR_RS14260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYAGR_RS14265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYAGR_RS14275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYAGR_RS14280	COG0268	Binds directly to 16S ribosomal RNA
CYAGR_RS14285	COG0084	hydrolase, TatD family'
CYAGR_RS14295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYAGR_RS14300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYAGR_RS14305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYAGR_RS14310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYAGR_RS14320	COG2223	nitrite transmembrane transporter activity
CYAGR_RS14350	COG0357	Ribosomal RNA small subunit methyltransferase G
CYAGR_RS14355	COG0484	heat shock protein binding
CYAGR_RS14365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYAGR_RS14370	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CYAGR_RS14385	COG0156	8-amino-7-oxononanoate synthase activity
CYAGR_RS14390	COG4974	Belongs to the 'phage' integrase family
CYAGR_RS14400	COG2801	Transposase and inactivated derivatives
CYAGR_RS14400	COG3415	Transposase
CYAGR_RS14415	COG4581	dead DEAH box helicase
CYAGR_RS14425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYAGR_RS14440	COG0347	Belongs to the P(II) protein family
CYAGR_RS14445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CYAGR_RS14450	COG1333	cytochrome c biogenesis protein
CYAGR_RS14455	COG4232	protein-disulfide reductase activity
CYAGR_RS14460	COG0772	Belongs to the SEDS family
CYAGR_RS14480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYAGR_RS14485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYAGR_RS14500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYAGR_RS14505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYAGR_RS14510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYAGR_RS14520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYAGR_RS14525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYAGR_RS14535	COG3119	arylsulfatase activity
CYAGR_RS14575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYAGR_RS14585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYAGR_RS14595	COG0678	peroxiredoxin activity
CYAGR_RS14605	COG3300	MHYT domain
CYAGR_RS14605	COG5001	Diguanylate cyclase
CYAGR_RS14610	COG0284	orotidine-5'-phosphate decarboxylase activity
CYAGR_RS14615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYAGR_RS14620	COG1231	oxidoreductase activity
CYAGR_RS14645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYAGR_RS14660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYAGR_RS14670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYAGR_RS14675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYAGR_RS14680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CYAGR_RS14690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYAGR_RS14700	COG0151	Belongs to the GarS family
CYAGR_RS14705	COG5002	protein histidine kinase activity
CYAGR_RS14710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CYAGR_RS14725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYAGR_RS14730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYAGR_RS14735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CYAGR_RS14740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYAGR_RS14745	COG0217	transcriptional regulatory protein
CYAGR_RS14750	COG0363	glucosamine-6-phosphate deaminase activity
CYAGR_RS14755	COG2247	cell wall binding repeat
CYAGR_RS14755	COG2385	sporulation resulting in formation of a cellular spore
CYAGR_RS14760	COG1234	tRNA 3'-trailer cleavage
CYAGR_RS14765	COG2010	Cytochrome c
CYAGR_RS14780	COG2264	protein methyltransferase activity
CYAGR_RS14785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYAGR_RS14805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYAGR_RS14830	COG0443	Heat shock 70 kDa protein
CYAGR_RS14845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYAGR_RS14850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CYAGR_RS14860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYAGR_RS14865	COG1032	radical SAM domain protein
CYAGR_RS14870	COG0459	protein refolding
CYAGR_RS14875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYAGR_RS14880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYAGR_RS14885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYAGR_RS14895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYAGR_RS14925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYAGR_RS14940	COG0006	proline dipeptidase activity
CYAGR_RS14945	COG1253	flavin adenine dinucleotide binding
CYAGR_RS14955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYAGR_RS14960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYAGR_RS14960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYAGR_RS14965	COG0686	Belongs to the AlaDH PNT family
CYAGR_RS14985	COG2205	protein histidine kinase activity
CYAGR_RS14990	COG2205	protein histidine kinase activity
CYAGR_RS14995	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CYAGR_RS15005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CYAGR_RS15025	COG0625	glutathione transferase activity
CYAGR_RS15070	COG1842	Phage shock protein A
CYAGR_RS15075	COG3118	belongs to the thioredoxin family
CYAGR_RS15080	COG0436	Aminotransferase
CYAGR_RS15090	COG0739	heme binding
CYAGR_RS15095	COG1136	(ABC) transporter
CYAGR_RS15095	COG0577	efflux transmembrane transporter activity
CYAGR_RS15105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYAGR_RS15120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CYAGR_RS15155	COG1845	cytochrome c oxidase, subunit III
CYAGR_RS15160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYAGR_RS15175	COG1612	heme a metabolic process
CYAGR_RS15180	COG0109	protoheme IX farnesyltransferase activity
CYAGR_RS15200	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CYAGR_RS15205	COG0459	protein refolding
CYAGR_RS15225	COG0463	Glycosyl transferase, family 2
CYAGR_RS15230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CYAGR_RS15245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYAGR_RS15255	COG1028	Short-chain dehydrogenase reductase Sdr
CYAGR_RS15270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYAGR_RS15280	COG1619	proteins homologs of microcin C7 resistance protein MccF
CYAGR_RS15285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYAGR_RS15290	COG0248	Ppx GppA phosphatase
CYAGR_RS15320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYAGR_RS15325	COG3258	Cytochrome c
CYAGR_RS15330	COG0723	plastoquinol--plastocyanin reductase activity
CYAGR_RS15340	COG0805	protein transport
CYAGR_RS15345	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CYAGR_RS15350	COG0194	GDP metabolic process
CYAGR_RS15365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYAGR_RS15370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYAGR_RS15380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CYAGR_RS15390	COG0012	GTP binding
CYAGR_RS15395	COG2084	Dehydrogenase
CYAGR_RS15405	COG0577	efflux transmembrane transporter activity
CYAGR_RS15430	COG0601	transmembrane transport
CYAGR_RS15455	COG0460	homoserine dehydrogenase
CYAGR_RS15465	COG2813	Specifically methylates the guanine in position
CYAGR_RS15475	COG2166	iron-sulfur cluster assembly
CYAGR_RS15495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYAGR_RS15500	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CYAGR_RS15515	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CYAGR_RS15520	COG2010	Cytochrome c
CYAGR_RS15530	COG2264	protein methyltransferase activity
CYAGR_RS15535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYAGR_RS15540	COG1611	Belongs to the LOG family
CYAGR_RS15545	COG3118	belongs to the thioredoxin family
CYAGR_RS15550	COG0516	GMP reductase activity
CYAGR_RS15565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYAGR_RS15570	COG0644	oxidoreductase
CYAGR_RS15575	COG0579	oxidoreductase
CYAGR_RS15585	COG0708	Exodeoxyribonuclease III
CYAGR_RS15610	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CYAGR_RS15620	COG0735	belongs to the Fur family
CYAGR_RS15630	COG4176	ABC-type proline glycine betaine transport system permease component
CYAGR_RS15635	COG1840	ABC-type Fe3 transport system, periplasmic component
CYAGR_RS15640	COG0523	cobalamin synthesis protein
CYAGR_RS15665	COG0701	Predicted permease
CYAGR_RS15675	COG0140	phosphoribosyl-ATP diphosphatase activity
CYAGR_RS15675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYAGR_RS15700	COG0702	epimerase
CYAGR_RS15705	COG1121	(ABC) transporter
CYAGR_RS15720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYAGR_RS15760	COG2010	Cytochrome c
CYAGR_RS15775	COG0159	tryptophan synthase activity
CYAGR_RS15860	COG0745	RESPONSE REGULATOR receiver
CYAGR_RS15875	COG0697	spore germination
CYAGR_RS15910	COG2132	Multicopper oxidase
CYAGR_RS15935	COG2217	Heavy metal translocating P-type atpase
CYAGR_RS15985	COG0346	lactoylglutathione lyase activity
CYAGR_RS16020	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CYAGR_RS16025	COG3259	Nickel-dependent hydrogenase
CYAGR_RS16035	COG0375	protein maturation
CYAGR_RS16045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYAGR_RS16055	COG0298	carbon dioxide binding
CYAGR_RS16060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CYAGR_RS16060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CYAGR_RS16060	COG1013	pyruvate-flavodoxin oxidoreductase activity
CYAGR_RS16060	COG0674	pyruvate-flavodoxin oxidoreductase activity
CYAGR_RS16065	COG0167	dihydroorotate dehydrogenase activity
CYAGR_RS16080	COG0071	Belongs to the small heat shock protein (HSP20) family
CYAGR_RS16105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYAGR_RS16105	COG0284	orotidine-5'-phosphate decarboxylase activity
CYAGR_RS16110	COG0281	malic enzyme
CYAGR_RS16135	COG1799	cell septum assembly
CYAGR_RS16140	COG0251	oxidation-reduction process
CYAGR_RS16145	COG3842	ATPase activity
CYAGR_RS16150	COG2208	phosphoserine phosphatase activity
CYAGR_RS16150	COG2770	Histidine kinase
CYAGR_RS16165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYAGR_RS16170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYAGR_RS16175	COG1132	(ABC) transporter
CYAGR_RS16185	COG0456	acetyltransferase
CYAGR_RS16200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYAGR_RS16235	COG4974	Belongs to the 'phage' integrase family
CYAGR_RS16260	COG4251	negative regulation of phosphorylation
CYAGR_RS16270	COG0308	aminopeptidase N
CYAGR_RS16295	COG1191	sigma factor activity
CYAGR_RS16305	COG2105	PFAM AIG2 family protein
CYAGR_RS16325	COG1074	ATP-dependent DNA helicase activity
CYAGR_RS16345	COG2226	methyltransferase
CYAGR_RS16375	COG1216	Glycosyl transferase, family 2
CYAGR_RS16380	COG1215	transferase activity, transferring glycosyl groups
CYAGR_RS16385	COG1216	Glycosyl transferase, family 2
CYAGR_RS16395	COG0297	glycogen (starch) synthase activity
CYAGR_RS16440	COG4942	peptidase
CYAGR_RS16480	COG0784	Response regulator, receiver
CYAGR_RS16480	COG2198	Histidine kinase
CYAGR_RS16480	COG5002	protein histidine kinase activity
CYAGR_RS16510	COG0737	Belongs to the 5'-nucleotidase family
CYAGR_RS16570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CYAGR_RS16590	COG3706	GGDEF domain
CYAGR_RS16615	COG2133	pyrroloquinoline quinone binding
CYAGR_RS16625	COG5001	Diguanylate cyclase
CYAGR_RS16625	COG3447	MASE1 domain protein
CYAGR_RS16625	COG5002	protein histidine kinase activity
CYAGR_RS16670	COG5001	Diguanylate cyclase
CYAGR_RS16670	COG3300	MHYT domain