locus-tag	class	description
CYCME_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYCME_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYCME_RS00020	COG0187	DNA topoisomerase II activity
CYCME_RS00055	COG0829	nickel cation binding
CYCME_RS00060	COG0831	urea catabolic process
CYCME_RS00065	COG0832	Belongs to the urease beta subunit family
CYCME_RS00070	COG0804	urea catabolic process
CYCME_RS00075	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CYCME_RS00085	COG0830	nickel cation binding
CYCME_RS00105	COG0751	glycine-tRNA ligase activity
CYCME_RS00115	COG0482	sulfurtransferase activity
CYCME_RS00130	COG0174	glutamine synthetase
CYCME_RS00145	COG2204	response regulator
CYCME_RS00150	COG0167	dihydroorotate dehydrogenase activity
CYCME_RS00155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYCME_RS00160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYCME_RS00165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CYCME_RS00170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYCME_RS00185	COG4942	peptidase
CYCME_RS00190	COG0793	Belongs to the peptidase S41A family
CYCME_RS00210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYCME_RS00215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYCME_RS00220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYCME_RS00220	COG2813	Specifically methylates the guanine in position
CYCME_RS00235	COG0708	Exodeoxyribonuclease III
CYCME_RS00240	COG0254	rRNA binding
CYCME_RS00305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYCME_RS00310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYCME_RS00320	COG0067	glutamate synthase
CYCME_RS00320	COG0070	glutamate synthase
CYCME_RS00320	COG0069	glutamate synthase activity
CYCME_RS00325	COG0493	'glutamate synthase
CYCME_RS00330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYCME_RS00355	COG4966	pilus assembly protein PilW
CYCME_RS00395	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CYCME_RS00400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYCME_RS00405	COG2022	thiamine diphosphate biosynthetic process
CYCME_RS00405	COG2104	thiamine diphosphate biosynthetic process
CYCME_RS00410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYCME_RS00430	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CYCME_RS00445	COG1643	Atp-dependent helicase
CYCME_RS00465	COG0730	response to heat
CYCME_RS00470	COG0617	tRNA 3'-terminal CCA addition
CYCME_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYCME_RS00490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYCME_RS00495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYCME_RS00505	COG1610	YqeY-like protein
CYCME_RS00535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CYCME_RS00545	COG0625	glutathione transferase activity
CYCME_RS00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYCME_RS00555	COG1136	(ABC) transporter
CYCME_RS00560	COG1136	(ABC) transporter
CYCME_RS00560	COG0577	efflux transmembrane transporter activity
CYCME_RS00565	COG0577	efflux transmembrane transporter activity
CYCME_RS00565	COG1136	(ABC) transporter
CYCME_RS00585	COG0798	PFAM Bile acid sodium symporter
CYCME_RS00595	COG1238	metal cluster binding
CYCME_RS00610	COG2095	MarC family integral membrane protein
CYCME_RS00615	COG0519	Catalyzes the synthesis of GMP from XMP
CYCME_RS00645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CYCME_RS00685	COG0484	heat shock protein binding
CYCME_RS00760	COG0330	HflC and HflK could
CYCME_RS00780	COG1047	Peptidyl-prolyl cis-trans
CYCME_RS00785	COG0613	PHP domain protein
CYCME_RS00790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CYCME_RS00795	COG4660	Part of a membrane complex involved in electron transport
CYCME_RS00800	COG4659	FMN binding
CYCME_RS00805	COG4658	electron transport chain
CYCME_RS00810	COG4656	Part of a membrane complex involved in electron transport
CYCME_RS00815	COG2878	Part of a membrane complex involved in electron transport
CYCME_RS00820	COG4657	Part of a membrane complex involved in electron transport
CYCME_RS00825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYCME_RS00825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYCME_RS00830	COG0489	protein tyrosine kinase activity
CYCME_RS00835	COG0717	Belongs to the dCTP deaminase family
CYCME_RS00845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CYCME_RS00850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYCME_RS00865	COG0628	permease
CYCME_RS00875	COG0668	transmembrane transport
CYCME_RS00885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYCME_RS00900	COG1393	Belongs to the ArsC family
CYCME_RS00905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CYCME_RS00905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CYCME_RS00910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYCME_RS00915	COG1519	Transferase
CYCME_RS00925	COG1538	Outer membrane efflux protein
CYCME_RS00930	COG1490	D-aminoacyl-tRNA deacylase activity
CYCME_RS00940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYCME_RS00960	COG0210	DNA helicase
CYCME_RS00975	COG0667	Aldo Keto reductase
CYCME_RS01000	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CYCME_RS01025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYCME_RS01125	COG4638	Rieske (2fe-2S)
CYCME_RS01160	COG0318	PFAM AMP-dependent synthetase and ligase
CYCME_RS01170	COG0438	transferase activity, transferring glycosyl groups
CYCME_RS01170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYCME_RS01175	COG0688	phosphatidylethanolamine metabolic process
CYCME_RS01190	COG1702	phosphate starvation-inducible protein PhoH
CYCME_RS01195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CYCME_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS01210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CYCME_RS01225	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS01230	COG0625	glutathione transferase activity
CYCME_RS01235	COG4638	Rieske (2fe-2S)
CYCME_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS01255	COG3384	dioxygenase
CYCME_RS01260	COG3038	cytochrome b561
CYCME_RS01270	COG1362	aminopeptidase activity
CYCME_RS01275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYCME_RS01300	COG2020	methyltransferase activity
CYCME_RS01305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYCME_RS01310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYCME_RS01315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CYCME_RS01320	COG3100	YcgL domain-containing protein
CYCME_RS01325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CYCME_RS01335	COG0189	ligase activity
CYCME_RS01345	COG1678	Uncharacterized ACR, COG1678
CYCME_RS01350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYCME_RS01355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYCME_RS01360	COG0540	Belongs to the ATCase OTCase family
CYCME_RS01370	COG0543	2 iron, 2 sulfur cluster binding
CYCME_RS01380	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CYCME_RS01390	COG4628	conserved protein (DUF2132)
CYCME_RS01395	COG0488	(ABC) transporter
CYCME_RS01400	COG0514	ATP-dependent DNA helicase (RecQ)
CYCME_RS01405	COG0659	secondary active sulfate transmembrane transporter activity
CYCME_RS01420	COG0513	Belongs to the DEAD box helicase family
CYCME_RS01430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYCME_RS01435	COG1793	dna ligase
CYCME_RS01440	COG2873	o-acetylhomoserine
CYCME_RS01445	COG1671	Belongs to the UPF0178 family
CYCME_RS01450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYCME_RS01465	COG5001	Diguanylate cyclase
CYCME_RS01465	COG5002	protein histidine kinase activity
CYCME_RS01495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYCME_RS01500	COG0140	phosphoribosyl-ATP diphosphatase activity
CYCME_RS01505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYCME_RS01510	COG0107	imidazoleglycerol-phosphate synthase activity
CYCME_RS01515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYCME_RS01520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYCME_RS01525	COG0131	Imidazoleglycerol-phosphate dehydratase
CYCME_RS01535	COG2414	aldehyde ferredoxin oxidoreductase
CYCME_RS01540	COG1217	gtp-binding protein TYPA
CYCME_RS01550	COG0500	methyltransferase
CYCME_RS01555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYCME_RS01560	COG0569	domain protein
CYCME_RS01565	COG2204	response regulator
CYCME_RS01570	COG5000	phosphorelay sensor kinase activity
CYCME_RS01585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYCME_RS01590	COG0242	peptide deformylase activity
CYCME_RS01600	COG0758	DNA mediated transformation
CYCME_RS01605	COG2922	Belongs to the Smg family
CYCME_RS01610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYCME_RS01610	COG1754	DNA topoisomerase type I activity
CYCME_RS01615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYCME_RS01620	COG0009	L-threonylcarbamoyladenylate synthase
CYCME_RS01625	COG0408	coproporphyrinogen oxidase activity
CYCME_RS01630	COG2854	intermembrane phospholipid transfer
CYCME_RS01640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYCME_RS01645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CYCME_RS01650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYCME_RS01655	COG1704	LemA family
CYCME_RS01675	COG0425	Belongs to the sulfur carrier protein TusA family
CYCME_RS01680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYCME_RS01710	COG2972	Histidine kinase
CYCME_RS01710	COG0745	RESPONSE REGULATOR receiver
CYCME_RS01715	COG0165	Argininosuccinate lyase
CYCME_RS01730	COG0678	peroxiredoxin activity
CYCME_RS01735	COG0583	DNA-binding transcription factor activity
CYCME_RS01740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CYCME_RS01745	COG2194	sulfuric ester hydrolase activity
CYCME_RS01755	COG0019	diaminopimelate decarboxylase activity
CYCME_RS01760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYCME_RS01780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CYCME_RS01785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CYCME_RS01805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYCME_RS01815	COG1403	HNH endonuclease
CYCME_RS01825	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CYCME_RS01845	COG0126	phosphoglycerate kinase activity
CYCME_RS01885	COG0347	Belongs to the P(II) protein family
CYCME_RS01890	COG0004	ammonium transporteR
CYCME_RS01900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYCME_RS01920	COG0069	glutamate synthase activity
CYCME_RS01930	COG0385	Bile acid
CYCME_RS01935	COG0205	6-phosphofructokinase activity
CYCME_RS01950	COG1538	Outer membrane efflux protein
CYCME_RS01955	COG2197	response regulator
CYCME_RS01960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYCME_RS01990	COG3245	cytochrome
CYCME_RS01995	COG0210	DNA helicase
CYCME_RS02000	COG0606	chelatase, subunit chli
CYCME_RS02015	COG0347	Belongs to the P(II) protein family
CYCME_RS02020	COG0004	ammonium transporteR
CYCME_RS02025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYCME_RS02030	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CYCME_RS02040	COG1666	GTP binding
CYCME_RS02045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CYCME_RS02075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYCME_RS02080	COG0546	phosphoglycolate phosphatase activity
CYCME_RS02090	COG0512	Glutamine amidotransferase of anthranilate synthase
CYCME_RS02095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYCME_RS02100	COG0134	indole-3-glycerol-phosphate synthase activity
CYCME_RS02105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYCME_RS02110	COG1765	OsmC-like protein
CYCME_RS02125	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CYCME_RS02135	COG0175	sulfate reduction
CYCME_RS02140	COG2895	sulfate adenylyltransferase (ATP) activity
CYCME_RS02145	COG0529	Catalyzes the synthesis of activated sulfate
CYCME_RS02150	COG0529	Catalyzes the synthesis of activated sulfate
CYCME_RS02165	COG1088	dTDP-glucose 4,6-dehydratase activity
CYCME_RS02170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CYCME_RS02190	COG1682	transport, permease protein
CYCME_RS02220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CYCME_RS02230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYCME_RS02240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CYCME_RS02245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CYCME_RS02275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYCME_RS02280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYCME_RS02290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYCME_RS02300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYCME_RS02305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYCME_RS02315	COG0659	secondary active sulfate transmembrane transporter activity
CYCME_RS02320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYCME_RS02325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYCME_RS02340	COG3079	Belongs to the UPF0149 family
CYCME_RS02345	COG0006	proline dipeptidase activity
CYCME_RS02350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYCME_RS02355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYCME_RS02365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYCME_RS02370	COG0509	glycine decarboxylation via glycine cleavage system
CYCME_RS02375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYCME_RS02385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYCME_RS02410	COG3746	phosphate-selective porin O and P
CYCME_RS02415	COG2824	Alkylphosphonate utilization operon protein PhnA
CYCME_RS02425	COG0390	transport system, permease component
CYCME_RS02450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CYCME_RS02450	COG0116	Belongs to the methyltransferase superfamily
CYCME_RS02460	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYCME_RS02465	COG0018	arginyl-trna synthetase
CYCME_RS02470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CYCME_RS02485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYCME_RS02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYCME_RS02505	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CYCME_RS02510	COG2816	NAD+ diphosphatase activity
CYCME_RS02515	COG0494	nUDIX hydrolase
CYCME_RS02520	COG4807	Protein conserved in bacteria
CYCME_RS02530	COG0308	aminopeptidase N
CYCME_RS02535	COG2363	Small membrane protein
CYCME_RS02540	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYCME_RS02545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYCME_RS02565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYCME_RS02570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYCME_RS02580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYCME_RS02585	COG0756	dUTP diphosphatase activity
CYCME_RS02595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYCME_RS02605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CYCME_RS02610	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYCME_RS02615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYCME_RS02620	COG0596	Alpha beta hydrolase
CYCME_RS02630	COG0137	argininosuccinate synthase activity
CYCME_RS02665	COG0352	thiamine-phosphate diphosphorylase activity
CYCME_RS02685	COG3409	Peptidoglycan-binding domain 1 protein
CYCME_RS02685	COG3267	Type II secretory pathway component ExeA
CYCME_RS02700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CYCME_RS02705	COG1459	type II secretion system
CYCME_RS02750	COG0788	formyltetrahydrofolate deformylase activity
CYCME_RS02760	COG0315	cyclic pyranopterin monophosphate synthase activity
CYCME_RS02765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CYCME_RS02770	COG0314	molybdopterin synthase activity
CYCME_RS02775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYCME_RS02780	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CYCME_RS02790	COG0069	glutamate synthase activity
CYCME_RS02795	COG0028	Belongs to the TPP enzyme family
CYCME_RS02805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYCME_RS02810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CYCME_RS02820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYCME_RS02825	COG2967	ApaG domain
CYCME_RS02830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYCME_RS02850	COG0586	Pfam SNARE associated Golgi protein
CYCME_RS02860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYCME_RS02870	COG3220	belongs to the UPF0276 family
CYCME_RS02880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYCME_RS02885	COG1011	Hydrolase
CYCME_RS02905	COG0151	Belongs to the GarS family
CYCME_RS02910	COG0138	bifunctional purine biosynthesis protein purh
CYCME_RS02915	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CYCME_RS02920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYCME_RS02930	COG2264	protein methyltransferase activity
CYCME_RS02935	COG0439	Biotin carboxylase
CYCME_RS02940	COG0511	ligase activity, forming carbon-carbon bonds
CYCME_RS02945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYCME_RS02950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYCME_RS02955	COG4232	protein-disulfide reductase activity
CYCME_RS02990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYCME_RS02995	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CYCME_RS03005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYCME_RS03010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYCME_RS03015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYCME_RS03020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYCME_RS03025	COG3064	Membrane
CYCME_RS03025	COG0515	serine threonine protein kinase
CYCME_RS03025	COG4991	sh3 domain protein
CYCME_RS03030	COG1561	YicC-like family, N-terminal region
CYCME_RS03040	COG1758	RNA polymerase activity
CYCME_RS03045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYCME_RS03055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYCME_RS03060	COG3161	chorismate lyase activity
CYCME_RS03065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYCME_RS03070	COG1040	competence protein
CYCME_RS03075	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYCME_RS03080	COG0156	8-amino-7-oxononanoate synthase activity
CYCME_RS03085	COG0596	Alpha beta hydrolase
CYCME_RS03090	COG2226	methyltransferase
CYCME_RS03095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CYCME_RS03100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYCME_RS03105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYCME_RS03130	COG1612	heme a metabolic process
CYCME_RS03135	COG0109	protoheme IX farnesyltransferase activity
CYCME_RS03150	COG2177	Part of the ABC transporter FtsEX involved in
CYCME_RS03155	COG2884	Cell division ATP-binding protein ftsE
CYCME_RS03160	COG0552	protein localization to endoplasmic reticulum
CYCME_RS03165	COG0612	Peptidase, M16
CYCME_RS03170	COG0612	Peptidase, M16
CYCME_RS03175	COG0742	ribosomal rna small subunit methyltransferase
CYCME_RS03185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CYCME_RS03190	COG0405	Gamma-glutamyltransferase
CYCME_RS03215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYCME_RS03235	COG1131	(ABC) transporter
CYCME_RS03250	COG2267	carboxylic ester hydrolase activity
CYCME_RS03255	COG3971	2-oxopent-4-enoate hydratase activity
CYCME_RS03270	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CYCME_RS03295	COG2217	Heavy metal translocating P-type atpase
CYCME_RS03300	COG5001	Diguanylate cyclase
CYCME_RS03300	COG5002	protein histidine kinase activity
CYCME_RS03305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CYCME_RS03335	COG0438	transferase activity, transferring glycosyl groups
CYCME_RS03355	COG1132	(ABC) transporter
CYCME_RS03360	COG0438	transferase activity, transferring glycosyl groups
CYCME_RS03365	COG0515	serine threonine protein kinase
CYCME_RS03380	COG2192	nodulation
CYCME_RS03405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CYCME_RS03410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYCME_RS03415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CYCME_RS03420	COG3178	'Phosphotransferase
CYCME_RS03430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYCME_RS03435	COG0321	lipoyl(octanoyl) transferase activity
CYCME_RS03450	COG1686	Belongs to the peptidase S11 family
CYCME_RS03460	COG2951	lytic endotransglycosylase activity
CYCME_RS03465	COG0772	Belongs to the SEDS family
CYCME_RS03470	COG0768	penicillin binding
CYCME_RS03475	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CYCME_RS03480	COG1792	Involved in formation and maintenance of cell shape
CYCME_RS03485	COG1077	Cell shape determining protein MreB Mrl
CYCME_RS03490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYCME_RS03495	COG0154	amidase activity
CYCME_RS03500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYCME_RS03515	COG2890	protein-(glutamine-N5) methyltransferase activity
CYCME_RS03520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYCME_RS03525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYCME_RS03535	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CYCME_RS03540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYCME_RS03550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYCME_RS03555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CYCME_RS03560	COG0193	aminoacyl-tRNA hydrolase activity
CYCME_RS03580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYCME_RS03590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYCME_RS03595	COG0250	Participates in transcription elongation, termination and antitermination
CYCME_RS03600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYCME_RS03605	COG0081	regulation of translation
CYCME_RS03610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYCME_RS03615	COG0222	ribosome binding
CYCME_RS03620	COG0085	RNA polymerase activity
CYCME_RS03625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYCME_RS03630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYCME_RS03635	COG0049	tRNA binding
CYCME_RS03640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYCME_RS03645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYCME_RS03650	COG0051	transcription antitermination factor activity, RNA binding
CYCME_RS03655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYCME_RS03660	COG0088	Forms part of the polypeptide exit tunnel
CYCME_RS03665	COG0089	rRNA binding
CYCME_RS03670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYCME_RS03675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYCME_RS03685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYCME_RS03690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYCME_RS03695	COG0255	Belongs to the universal ribosomal protein uL29 family
CYCME_RS03700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYCME_RS03705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CYCME_RS03710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYCME_RS03715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYCME_RS03720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYCME_RS03725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYCME_RS03735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYCME_RS03740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYCME_RS03745	COG1841	ribosomal large subunit assembly
CYCME_RS03750	COG0200	Binds to the 23S rRNA
CYCME_RS03755	COG0201	protein transport
CYCME_RS03765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYCME_RS03770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYCME_RS03775	COG0202	RNA polymerase activity
CYCME_RS03785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CYCME_RS03790	COG0730	response to heat
CYCME_RS03805	COG2918	glutathione biosynthetic process
CYCME_RS03815	COG0303	'Molybdopterin
CYCME_RS03825	COG4662	Binding-protein-dependent transport system inner membrane component
CYCME_RS03840	COG2902	Dehydrogenase
CYCME_RS03845	COG2267	carboxylic ester hydrolase activity
CYCME_RS03860	COG1131	(ABC) transporter
CYCME_RS03870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYCME_RS03875	COG1702	phosphate starvation-inducible protein PhoH
CYCME_RS03880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYCME_RS03885	COG4535	Mg2 and Co2 transporter CorC
CYCME_RS03890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYCME_RS03900	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CYCME_RS03910	COG0495	leucyl-tRNA aminoacylation
CYCME_RS03925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYCME_RS03930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYCME_RS03940	COG2885	chlorophyll binding
CYCME_RS03945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CYCME_RS03960	COG3164	Protein of unknown function
CYCME_RS03970	COG0312	modulator of DNA gyrase
CYCME_RS03975	COG0312	modulator of DNA gyrase
CYCME_RS03980	COG2239	Acts as a magnesium transporter
CYCME_RS03985	COG1660	Displays ATPase and GTPase activities
CYCME_RS03995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CYCME_RS04000	COG1137	ATPase activity
CYCME_RS04005	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CYCME_RS04015	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CYCME_RS04030	COG1127	ABC transporter
CYCME_RS04035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYCME_RS04040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CYCME_RS04050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYCME_RS04055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYCME_RS04065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYCME_RS04070	COG0723	plastoquinol--plastocyanin reductase activity
CYCME_RS04075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYCME_RS04080	COG2857	Cytochrome c1
CYCME_RS04085	COG0625	glutathione transferase activity
CYCME_RS04090	COG2969	positive regulation of protein catabolic process
CYCME_RS04095	COG0318	PFAM AMP-dependent synthetase and ligase
CYCME_RS04110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CYCME_RS04115	COG0531	amino acid
CYCME_RS04120	COG4681	YaeQ
CYCME_RS04125	COG1054	Belongs to the UPF0176 family
CYCME_RS04135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYCME_RS04145	COG0076	glutamate decarboxylase activity
CYCME_RS04155	COG0826	peptidase U32
CYCME_RS04165	COG4628	conserved protein (DUF2132)
CYCME_RS04200	COG0723	plastoquinol--plastocyanin reductase activity
CYCME_RS04205	COG0501	Belongs to the peptidase M48B family
CYCME_RS04210	COG0248	Ppx GppA phosphatase
CYCME_RS04215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYCME_RS04220	COG3204	pilus organization
CYCME_RS04235	COG0386	Belongs to the glutathione peroxidase family
CYCME_RS04250	COG0488	(ABC) transporter
CYCME_RS04255	COG0045	succinate-CoA ligase (ADP-forming) activity
CYCME_RS04255	COG1042	CoA-binding domain protein
CYCME_RS04255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CYCME_RS04260	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYCME_RS04265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYCME_RS04270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYCME_RS04275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYCME_RS04275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYCME_RS04290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CYCME_RS04295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYCME_RS04300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYCME_RS04305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CYCME_RS04315	COG0779	Required for maturation of 30S ribosomal subunits
CYCME_RS04320	COG0195	Participates in both transcription termination and antitermination
CYCME_RS04320	COG2251	uridine kinase activity
CYCME_RS04325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYCME_RS04335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYCME_RS04340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYCME_RS04345	COG1185	polyribonucleotide nucleotidyltransferase activity
CYCME_RS04350	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CYCME_RS04355	COG0322	excinuclease ABC activity
CYCME_RS04360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYCME_RS04390	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CYCME_RS04400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYCME_RS04405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYCME_RS04410	COG0537	adenosine 5'-monophosphoramidase activity
CYCME_RS04420	COG0501	Belongs to the peptidase M48B family
CYCME_RS04430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYCME_RS04435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYCME_RS04435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYCME_RS04440	COG0802	atpase or kinase
CYCME_RS04445	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYCME_RS04450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYCME_RS04455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYCME_RS04460	COG1923	regulation of RNA biosynthetic process
CYCME_RS04465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYCME_RS04470	COG0330	HflC and HflK could
CYCME_RS04475	COG0330	HflC and HflK could
CYCME_RS04485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CYCME_RS04495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYCME_RS04500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYCME_RS04500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYCME_RS04500	COG1703	isobutyryl-CoA mutase activity
CYCME_RS04535	COG1987	bacterial-type flagellum assembly
CYCME_RS04540	COG1684	flagellar biosynthetic protein fliR
CYCME_RS04550	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CYCME_RS04570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CYCME_RS04585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CYCME_RS04605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYCME_RS04620	COG1716	ATPase activity
CYCME_RS04620	COG5001	Diguanylate cyclase
CYCME_RS04630	COG1509	lysine 2,3-aminomutase activity
CYCME_RS04635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYCME_RS04640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CYCME_RS04645	COG3647	Membrane
CYCME_RS04650	COG0688	phosphatidylethanolamine metabolic process
CYCME_RS04655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CYCME_RS04665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CYCME_RS04670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYCME_RS04675	COG3022	response to hydroperoxide
CYCME_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS04695	COG3243	poly(R)-hydroxyalkanoic acid synthase
CYCME_RS04705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYCME_RS04710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CYCME_RS04715	COG0436	Aminotransferase
CYCME_RS04725	COG0303	'Molybdopterin
CYCME_RS04730	COG1763	Mo-molybdopterin cofactor biosynthetic process
CYCME_RS04740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CYCME_RS04745	COG2900	Belongs to the SlyX family
CYCME_RS04760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYCME_RS04765	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CYCME_RS04770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYCME_RS04785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYCME_RS04795	COG1538	Outer membrane efflux protein
CYCME_RS04800	COG1166	arginine decarboxylase activity
CYCME_RS04805	COG1748	Saccharopine dehydrogenase
CYCME_RS04815	COG0010	Belongs to the arginase family
CYCME_RS04830	COG1401	restriction endodeoxyribonuclease activity
CYCME_RS04835	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CYCME_RS04845	COG0732	type I restriction modification DNA specificity domain
CYCME_RS04850	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CYCME_RS04860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYCME_RS04865	COG0733	neurotransmitter:sodium symporter activity
CYCME_RS04870	COG2867	negative regulation of translational initiation
CYCME_RS04875	COG2914	Belongs to the UPF0125 (RnfH) family
CYCME_RS04880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYCME_RS04885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CYCME_RS04890	COG4638	Rieske (2fe-2S)
CYCME_RS04905	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYCME_RS04910	COG0735	belongs to the Fur family
CYCME_RS04915	COG0497	DNA recombination
CYCME_RS04920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYCME_RS04925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYCME_RS04930	COG0443	Heat shock 70 kDa protein
CYCME_RS04935	COG0484	heat shock protein binding
CYCME_RS04940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYCME_RS04950	COG0505	Belongs to the CarA family
CYCME_RS04960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYCME_RS04970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CYCME_RS04975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYCME_RS04980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYCME_RS04985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYCME_RS04990	COG0149	triose-phosphate isomerase activity
CYCME_RS05010	COG0039	L-malate dehydrogenase activity
CYCME_RS05015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CYCME_RS05020	COG0746	molybdenum cofactor guanylyltransferase activity
CYCME_RS05025	COG3383	formate dehydrogenase (NAD+) activity
CYCME_RS05030	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CYCME_RS05035	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CYCME_RS05040	COG1469	GTP cyclohydrolase I activity
CYCME_RS05045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYCME_RS05050	COG0142	geranyltranstransferase activity
CYCME_RS05055	COG1722	exodeoxyribonuclease VII activity
CYCME_RS05060	COG1592	Rubrerythrin
CYCME_RS05075	COG5001	Diguanylate cyclase
CYCME_RS05075	COG5002	protein histidine kinase activity
CYCME_RS05130	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYCME_RS05165	COG1815	bacterial-type flagellum-dependent cell motility
CYCME_RS05175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CYCME_RS05180	COG1749	Flagellar hook protein flgE
CYCME_RS05190	COG4786	Flagellar basal body rod
CYCME_RS05195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CYCME_RS05205	COG3951	Flagellar rod assembly protein muramidase FlgJ
CYCME_RS05205	COG1705	Flagellar rod assembly protein muramidase FlgJ
CYCME_RS05225	COG1334	flagellar protein FlaG
CYCME_RS05230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CYCME_RS05235	COG1516	flagellar protein fliS
CYCME_RS05260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYCME_RS05265	COG0563	adenylate kinase activity
CYCME_RS05270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYCME_RS05280	COG2917	probably involved in intracellular septation
CYCME_RS05290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CYCME_RS05300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYCME_RS05305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYCME_RS05310	COG1393	Belongs to the ArsC family
CYCME_RS05315	COG2171	N-acyltransferase activity
CYCME_RS05335	COG1131	(ABC) transporter
CYCME_RS05345	COG3706	GGDEF domain
CYCME_RS05350	COG0739	heme binding
CYCME_RS05350	COG0741	lytic transglycosylase activity
CYCME_RS05350	COG1196	nuclear chromosome segregation
CYCME_RS05360	COG0424	maF-like protein
CYCME_RS05370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYCME_RS05375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYCME_RS05385	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS05390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYCME_RS05395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYCME_RS05400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYCME_RS05405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYCME_RS05410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYCME_RS05415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYCME_RS05430	COG0084	hydrolase, TatD family'
CYCME_RS05445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYCME_RS05455	COG2091	lysine biosynthetic process via aminoadipic acid
CYCME_RS05470	COG0700	Nucleoside recognition
CYCME_RS05475	COG3956	TIGRFAM MazG family protein
CYCME_RS05480	COG1278	Cold shock
CYCME_RS05485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYCME_RS05490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYCME_RS05495	COG0584	glycerophosphoryl diester phosphodiesterase
CYCME_RS05515	COG0640	Transcriptional regulator
CYCME_RS05520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYCME_RS05540	COG1733	regulation of RNA biosynthetic process
CYCME_RS05545	COG0431	NADPH-dependent FMN reductase
CYCME_RS05580	COG2267	carboxylic ester hydrolase activity
CYCME_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS05620	COG2205	protein histidine kinase activity
CYCME_RS05625	COG0745	RESPONSE REGULATOR receiver
CYCME_RS05645	COG4638	Rieske (2fe-2S)
CYCME_RS05680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYCME_RS05685	COG0343	queuine tRNA-ribosyltransferase activity
CYCME_RS05690	COG1862	Preprotein translocase
CYCME_RS05695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYCME_RS05700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYCME_RS05720	COG1104	cysteine desulfurase activity
CYCME_RS05725	COG0300	oxidoreductase activity
CYCME_RS05730	COG1322	Protein conserved in bacteria
CYCME_RS05735	COG0546	phosphoglycolate phosphatase activity
CYCME_RS05740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYCME_RS05745	COG0402	S-adenosylhomocysteine deaminase activity
CYCME_RS05750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYCME_RS05760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYCME_RS05765	COG0670	Belongs to the BI1 family
CYCME_RS05775	COG0004	ammonium transporteR
CYCME_RS05785	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS05790	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS05800	COG1024	Enoyl-CoA hydratase
CYCME_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS05810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYCME_RS05820	COG0542	response to heat
CYCME_RS05825	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS05840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CYCME_RS05855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYCME_RS05860	COG0183	Belongs to the thiolase family
CYCME_RS05865	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS05870	COG1309	transcriptional regulator
CYCME_RS05875	COG1024	Enoyl-CoA hydratase
CYCME_RS05880	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS05885	COG2030	dehydratase
CYCME_RS05890	COG0427	acetyl-CoA hydrolase
CYCME_RS05915	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS05920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYCME_RS05940	COG0183	Belongs to the thiolase family
CYCME_RS05945	COG1902	pentaerythritol trinitrate reductase activity
CYCME_RS05945	COG0446	pyridine nucleotide-disulphide oxidoreductase
CYCME_RS05955	COG2030	dehydratase
CYCME_RS05960	COG0827	DNA restriction-modification system
CYCME_RS05965	COG0827	DNA restriction-modification system
CYCME_RS05975	COG0318	PFAM AMP-dependent synthetase and ligase
CYCME_RS05980	COG0183	Belongs to the thiolase family
CYCME_RS05990	COG1024	Enoyl-CoA hydratase
CYCME_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS06000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CYCME_RS06045	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS06050	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS06085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CYCME_RS06090	COG0183	Belongs to the thiolase family
CYCME_RS06105	COG1530	ribonuclease E activity
CYCME_RS06110	COG0564	pseudouridine synthase activity
CYCME_RS06115	COG0546	phosphoglycolate phosphatase activity
CYCME_RS06120	COG0616	signal peptide processing
CYCME_RS06155	COG0482	sulfurtransferase activity
CYCME_RS06165	COG0583	DNA-binding transcription factor activity
CYCME_RS06170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CYCME_RS06185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYCME_RS06190	COG0542	response to heat
CYCME_RS06195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYCME_RS06200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CYCME_RS06205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CYCME_RS06210	COG0492	ferredoxin-NADP+ reductase activity
CYCME_RS06215	COG0686	Belongs to the AlaDH PNT family
CYCME_RS06285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYCME_RS06295	COG0672	)-iron permease
CYCME_RS06330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CYCME_RS06340	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CYCME_RS06370	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYCME_RS06440	COG2217	Heavy metal translocating P-type atpase
CYCME_RS06505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYCME_RS06530	COG1230	cation diffusion facilitator family transporter
CYCME_RS06535	COG0672	)-iron permease
CYCME_RS06540	COG4644	lycopene metabolic process
CYCME_RS06550	COG1937	Protein conserved in bacteria
CYCME_RS06555	COG2132	Multicopper oxidase
CYCME_RS06640	COG2132	Multicopper oxidase
CYCME_RS06690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYCME_RS06695	COG0523	cobalamin synthesis protein
CYCME_RS06705	COG0577	efflux transmembrane transporter activity
CYCME_RS06705	COG1136	(ABC) transporter
CYCME_RS06715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYCME_RS06725	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYCME_RS06735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYCME_RS06740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYCME_RS06745	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CYCME_RS06770	COG2197	response regulator
CYCME_RS06775	COG4251	negative regulation of phosphorylation
CYCME_RS06780	COG0189	ligase activity
CYCME_RS06790	COG0189	ligase activity
CYCME_RS06790	COG4067	protein conserved in archaea
CYCME_RS06810	COG1088	dTDP-glucose 4,6-dehydratase activity
CYCME_RS06870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CYCME_RS06895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYCME_RS06935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYCME_RS06940	COG2755	lipolytic protein G-D-S-L family
CYCME_RS06940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYCME_RS06990	COG0673	inositol 2-dehydrogenase activity
CYCME_RS06995	COG0673	inositol 2-dehydrogenase activity
CYCME_RS07015	COG1216	Glycosyl transferase, family 2
CYCME_RS07035	COG0438	transferase activity, transferring glycosyl groups
CYCME_RS07040	COG0673	inositol 2-dehydrogenase activity
CYCME_RS07060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYCME_RS07065	COG0438	transferase activity, transferring glycosyl groups
CYCME_RS07070	COG1215	transferase activity, transferring glycosyl groups
CYCME_RS07145	COG3267	Type II secretory pathway component ExeA
CYCME_RS07145	COG3409	Peptidoglycan-binding domain 1 protein
CYCME_RS07175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYCME_RS07180	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CYCME_RS07180	COG0662	Cupin 2, conserved barrel domain protein
CYCME_RS07185	COG0545	Peptidyl-prolyl cis-trans isomerase
CYCME_RS07195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CYCME_RS07200	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CYCME_RS07205	COG1674	ftsk spoiiie
CYCME_RS07210	COG0742	ribosomal rna small subunit methyltransferase
CYCME_RS07230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYCME_RS07235	COG0215	cysteine-tRNA ligase activity
CYCME_RS07245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYCME_RS07250	COG2833	Protein of unknown function (DUF455)
CYCME_RS07255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYCME_RS07270	COG3707	response regulator
CYCME_RS07275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYCME_RS07275	COG1116	anion transmembrane transporter activity
CYCME_RS07280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYCME_RS07285	COG1116	anion transmembrane transporter activity
CYCME_RS07310	COG0217	transcriptional regulatory protein
CYCME_RS07325	COG1286	toxin biosynthetic process
CYCME_RS07335	COG0285	dihydrofolate synthase activity
CYCME_RS07340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYCME_RS07345	COG0159	tryptophan synthase activity
CYCME_RS07350	COG0133	tryptophan synthase activity
CYCME_RS07355	COG0135	phosphoribosylanthranilate isomerase activity
CYCME_RS07360	COG0101	tRNA pseudouridine synthase activity
CYCME_RS07365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CYCME_RS07370	COG1381	Involved in DNA repair and RecF pathway recombination
CYCME_RS07380	COG0571	ribonuclease III activity
CYCME_RS07390	COG0681	Belongs to the peptidase S26 family
CYCME_RS07395	COG0481	GTPase activity
CYCME_RS07400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYCME_RS07475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYCME_RS07495	COG0719	Fe-S assembly protein
CYCME_RS07500	COG0396	ATPase activity
CYCME_RS07505	COG0719	Fe-S assembly protein
CYCME_RS07525	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYCME_RS07535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYCME_RS07545	COG0436	Aminotransferase
CYCME_RS07560	COG1238	metal cluster binding
CYCME_RS07565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYCME_RS07570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYCME_RS07580	COG1968	undecaprenyl-diphosphatase activity
CYCME_RS07585	COG0585	pseudouridine synthase activity
CYCME_RS07590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYCME_RS07600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CYCME_RS07605	COG0148	phosphopyruvate hydratase activity
CYCME_RS07610	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CYCME_RS07615	COG0504	CTP synthase activity
CYCME_RS07620	COG0037	tRNA processing
CYCME_RS07625	COG0825	malonyl-CoA metabolic process
CYCME_RS07635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYCME_RS07640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYCME_RS07645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYCME_RS07650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYCME_RS07655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYCME_RS07665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYCME_RS07670	COG0750	zinc metalloprotease
CYCME_RS07675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYCME_RS07680	COG0575	Belongs to the CDS family
CYCME_RS07685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYCME_RS07690	COG0233	cytoplasmic translational termination
CYCME_RS07695	COG0528	UMP kinase activity
CYCME_RS07700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYCME_RS07705	COG0052	Belongs to the universal ribosomal protein uS2 family
CYCME_RS07715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CYCME_RS07735	COG1074	ATP-dependent DNA helicase activity
CYCME_RS07775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYCME_RS07785	COG2304	oxidoreductase activity
CYCME_RS07805	COG0714	Associated with various cellular activities
CYCME_RS07810	COG2081	HI0933 family
CYCME_RS07825	COG4106	trans-aconitate 2-methyltransferase activity
CYCME_RS07830	COG1280	lysine exporter protein (LysE YggA)
CYCME_RS07835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYCME_RS07840	COG0494	nUDIX hydrolase
CYCME_RS07855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYCME_RS07865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYCME_RS07870	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CYCME_RS07880	COG1151	hydroxylamine reductase activity
CYCME_RS07885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYCME_RS07950	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CYCME_RS07960	COG4638	Rieske (2fe-2S)
CYCME_RS07965	COG0346	lactoylglutathione lyase activity
CYCME_RS07975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYCME_RS07990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYCME_RS08005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYCME_RS08010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CYCME_RS08015	COG0328	RNA-DNA hybrid ribonuclease activity
CYCME_RS08020	COG2226	methyltransferase
CYCME_RS08025	COG1388	LysM domain
CYCME_RS08025	COG0741	lytic transglycosylase activity
CYCME_RS08035	COG0560	Phosphoserine phosphatase
CYCME_RS08040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYCME_RS08045	COG0601	transmembrane transport
CYCME_RS08050	COG0747	negative chemotaxis
CYCME_RS08055	COG1301	dicarboxylic acid transport
CYCME_RS08060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYCME_RS08080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYCME_RS08085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYCME_RS08090	COG0740	serine-type endopeptidase activity
CYCME_RS08095	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYCME_RS08130	COG4638	Rieske (2fe-2S)
CYCME_RS08140	COG0346	lactoylglutathione lyase activity
CYCME_RS08150	COG1752	Esterase of the alpha-beta hydrolase superfamily
CYCME_RS08160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CYCME_RS08175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYCME_RS08195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYCME_RS08200	COG0583	DNA-binding transcription factor activity
CYCME_RS08205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYCME_RS08205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYCME_RS08210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYCME_RS08225	COG3237	CsbD-like
CYCME_RS08255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYCME_RS08295	COG1917	Cupin 2, conserved barrel domain protein
CYCME_RS08300	COG5285	phytanoyl-CoA dioxygenase
CYCME_RS08305	COG0527	aspartate kinase activity
CYCME_RS08325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CYCME_RS08330	COG0527	aspartate kinase activity
CYCME_RS08335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYCME_RS08345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYCME_RS08350	COG1546	Belongs to the CinA family
CYCME_RS08355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYCME_RS08360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYCME_RS08370	COG0335	large ribosomal subunit rRNA binding
CYCME_RS08375	COG0336	Belongs to the RNA methyltransferase TrmD family
CYCME_RS08380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYCME_RS08385	COG0228	four-way junction DNA binding
CYCME_RS08390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYCME_RS08395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYCME_RS08400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYCME_RS08405	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CYCME_RS08410	COG2835	tetraacyldisaccharide 4'-kinase activity
CYCME_RS08415	COG1663	tetraacyldisaccharide 4'-kinase activity
CYCME_RS08420	COG0848	biopolymer transport protein
CYCME_RS08425	COG0811	peptide transport
CYCME_RS08440	COG1136	(ABC) transporter
CYCME_RS08445	COG4591	ABC-type transport system involved in lipoprotein release permease component
CYCME_RS08455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYCME_RS08480	COG1472	Belongs to the glycosyl hydrolase 3 family
CYCME_RS08495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYCME_RS08525	COG2205	protein histidine kinase activity
CYCME_RS08525	COG5002	protein histidine kinase activity
CYCME_RS08525	COG0784	Response regulator, receiver
CYCME_RS08575	COG0437	4 iron, 4 sulfur cluster binding
CYCME_RS08580	COG0243	molybdopterin cofactor binding
CYCME_RS08585	COG0384	phenazine biosynthesis protein PhzF
CYCME_RS08590	COG2146	nitrite reductase [NAD(P)H] activity
CYCME_RS08595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYCME_RS08600	COG2223	nitrite transmembrane transporter activity
CYCME_RS08605	COG2815	serine threonine protein kinase
CYCME_RS08605	COG0515	serine threonine protein kinase
CYCME_RS08615	COG2815	serine threonine protein kinase
CYCME_RS08615	COG0515	serine threonine protein kinase
CYCME_RS08625	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CYCME_RS08630	COG0651	ATP synthesis coupled electron transport
CYCME_RS08640	COG0651	ATP synthesis coupled electron transport
CYCME_RS08645	COG0651	ATP synthesis coupled electron transport
CYCME_RS08650	COG1006	Multisubunit Na H antiporter MnhC subunit
CYCME_RS08665	COG1320	monovalent cation:proton antiporter activity
CYCME_RS08670	COG2212	antiporter activity
CYCME_RS08695	COG0375	protein maturation
CYCME_RS08705	COG3259	Nickel-dependent hydrogenase
CYCME_RS08710	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CYCME_RS08715	COG3383	formate dehydrogenase (NAD+) activity
CYCME_RS08720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CYCME_RS08725	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CYCME_RS08730	COG0298	carbon dioxide binding
CYCME_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS08795	COG0776	regulation of translation
CYCME_RS08800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYCME_RS08800	COG0072	phenylalanine-tRNA ligase activity
CYCME_RS08805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYCME_RS08810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYCME_RS08815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYCME_RS08820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYCME_RS08825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYCME_RS08835	COG0556	nucleotide-excision repair
CYCME_RS08840	COG0436	Aminotransferase
CYCME_RS08865	COG1132	(ABC) transporter
CYCME_RS08880	COG4638	Rieske (2fe-2S)
CYCME_RS08885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CYCME_RS08890	COG3047	cAMP biosynthetic process
CYCME_RS08895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYCME_RS08900	COG1295	ribonuclease BN
CYCME_RS08905	COG2151	metal-sulfur cluster biosynthetic enzyme
CYCME_RS08920	COG2217	Heavy metal translocating P-type atpase
CYCME_RS08930	COG3278	Belongs to the heme-copper respiratory oxidase family
CYCME_RS08945	COG2010	Cytochrome c
CYCME_RS08975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CYCME_RS08980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CYCME_RS08985	COG0469	pyruvate kinase activity
CYCME_RS08995	COG0180	Tryptophanyl-tRNA synthetase
CYCME_RS09000	COG1994	Peptidase M50
CYCME_RS09005	COG0009	L-threonylcarbamoyladenylate synthase
CYCME_RS09010	COG1214	PFAM Peptidase M22, glycoprotease
CYCME_RS09015	COG1199	ATP-dependent helicase activity
CYCME_RS09030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYCME_RS09035	COG5001	Diguanylate cyclase
CYCME_RS09035	COG5002	protein histidine kinase activity
CYCME_RS09045	COG0121	glutamine amidotransferase
CYCME_RS09060	COG0302	gtp cyclohydrolase
CYCME_RS09065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYCME_RS09070	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CYCME_RS09075	COG0511	ligase activity, forming carbon-carbon bonds
CYCME_RS09075	COG5016	pyruvate
CYCME_RS09100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CYCME_RS09130	COG4536	flavin adenine dinucleotide binding
CYCME_RS09145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYCME_RS09150	COG0305	Participates in initiation and elongation during chromosome replication
CYCME_RS09155	COG0359	binds to the 23S rRNA
CYCME_RS09165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYCME_RS09170	COG0360	Binds together with S18 to 16S ribosomal RNA
CYCME_RS09175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYCME_RS09180	COG0557	exoribonuclease II activity
CYCME_RS09185	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CYCME_RS09200	COG0318	PFAM AMP-dependent synthetase and ligase
CYCME_RS09205	COG0183	Belongs to the thiolase family
CYCME_RS09225	COG1024	Enoyl-CoA hydratase
CYCME_RS09225	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYCME_RS09230	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS09235	COG1555	photosystem II stabilization
CYCME_RS09235	COG1596	polysaccharide export
CYCME_RS09240	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CYCME_RS09250	COG0776	regulation of translation
CYCME_RS09260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYCME_RS09265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYCME_RS09270	COG0287	Prephenate dehydrogenase
CYCME_RS09275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYCME_RS09285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYCME_RS09290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CYCME_RS09305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYCME_RS09315	COG1196	nuclear chromosome segregation
CYCME_RS09320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CYCME_RS09330	COG0326	Molecular chaperone. Has ATPase activity
CYCME_RS09335	COG0385	Bile acid
CYCME_RS09340	COG0697	spore germination
CYCME_RS09350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYCME_RS09375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYCME_RS09380	COG1090	epimerase
CYCME_RS09390	COG0789	Transcriptional regulator
CYCME_RS09395	COG0415	Belongs to the DNA photolyase family
CYCME_RS09400	COG3040	lipid binding
CYCME_RS09420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYCME_RS09455	COG1595	DNA-templated transcription, initiation
CYCME_RS09460	COG3806	Anti-sigma factor
CYCME_RS09470	COG0569	domain protein
CYCME_RS09470	COG0189	ligase activity
CYCME_RS09480	COG0189	ligase activity
CYCME_RS09480	COG4067	protein conserved in archaea
CYCME_RS09490	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYCME_RS09490	COG3264	Mechanosensitive ion channel
CYCME_RS09495	COG2911	Protein conserved in bacteria
CYCME_RS09500	COG0729	surface antigen
CYCME_RS09505	COG2239	Acts as a magnesium transporter
CYCME_RS09510	COG3431	PFAM Phosphate-starvation-inducible E
CYCME_RS09515	COG0668	transmembrane transport
CYCME_RS09535	COG0189	ligase activity
CYCME_RS09565	COG1566	PFAM secretion protein HlyD family protein
CYCME_RS09575	COG0488	(ABC) transporter
CYCME_RS09580	COG1058	Belongs to the CinA family
CYCME_RS09580	COG1546	Belongs to the CinA family
CYCME_RS09590	COG3150	esterase
CYCME_RS09600	COG0284	orotidine-5'-phosphate decarboxylase activity
CYCME_RS09620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CYCME_RS09625	COG2267	carboxylic ester hydrolase activity
CYCME_RS09640	COG0842	Transport permease protein
CYCME_RS09645	COG0842	Transport permease protein
CYCME_RS09645	COG1129	ABC transporter
CYCME_RS09650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYCME_RS09655	COG0519	Catalyzes the synthesis of GMP from XMP
CYCME_RS09655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYCME_RS09670	COG0739	heme binding
CYCME_RS09680	COG1160	GTP binding
CYCME_RS09685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYCME_RS09690	COG2976	Protein conserved in bacteria
CYCME_RS09695	COG0124	histidyl-tRNA synthetase
CYCME_RS09705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYCME_RS09710	COG0105	UTP biosynthetic process
CYCME_RS09720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYCME_RS09735	COG0513	Belongs to the DEAD box helicase family
CYCME_RS09740	COG0488	(ABC) transporter
CYCME_RS09750	COG3122	Protein conserved in bacteria
CYCME_RS09755	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CYCME_RS09760	COG4181	ATPase activity
CYCME_RS09810	COG0288	reversible hydration of carbon dioxide
CYCME_RS09855	COG0792	nuclease activity
CYCME_RS09865	COG2823	Periplasmic or secreted lipoprotein
CYCME_RS09870	COG0277	FAD linked oxidase domain protein
CYCME_RS09875	COG0589	response to stress
CYCME_RS09890	COG3023	N-Acetylmuramoyl-L-alanine amidase
CYCME_RS09900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYCME_RS09905	COG0196	riboflavin kinase activity
CYCME_RS09910	COG0728	peptidoglycan biosynthetic process
CYCME_RS09920	COG0268	Binds directly to 16S ribosomal RNA
CYCME_RS09925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYCME_RS09930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYCME_RS09940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYCME_RS09945	COG0142	geranyltranstransferase activity
CYCME_RS09955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYCME_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS09980	COG1115	amino acid carrier protein
CYCME_RS10000	COG2937	Belongs to the GPAT DAPAT family
CYCME_RS10005	COG0037	tRNA processing
CYCME_RS10015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CYCME_RS10020	COG3706	GGDEF domain
CYCME_RS10020	COG5001	Diguanylate cyclase
CYCME_RS10020	COG4251	negative regulation of phosphorylation
CYCME_RS10020	COG2203	Gaf domain
CYCME_RS10025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYCME_RS10030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYCME_RS10035	COG3118	belongs to the thioredoxin family
CYCME_RS10040	COG2827	Endonuclease containing a URI domain
CYCME_RS10045	COG3091	SprT-like family
CYCME_RS10055	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYCME_RS10070	COG1132	(ABC) transporter
CYCME_RS10080	COG2925	Exonuclease
CYCME_RS10085	COG0517	IMP dehydrogenase activity
CYCME_RS10085	COG0516	GMP reductase activity
CYCME_RS10095	COG1477	protein flavinylation
CYCME_RS10100	COG2871	sodium ion transport
CYCME_RS10105	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CYCME_RS10110	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CYCME_RS10120	COG1805	sodium ion transport
CYCME_RS10125	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CYCME_RS10130	COG0842	Transport permease protein
CYCME_RS10135	COG1131	(ABC) transporter
CYCME_RS10140	COG0280	phosphate acetyltransferase
CYCME_RS10140	COG0281	malic enzyme
CYCME_RS10160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYCME_RS10170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CYCME_RS10180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYCME_RS10220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYCME_RS10225	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CYCME_RS10310	COG4638	Rieske (2fe-2S)
CYCME_RS10360	COG0163	prenyltransferase activity
CYCME_RS10380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYCME_RS10395	COG1012	belongs to the aldehyde dehydrogenase family
CYCME_RS10400	COG1012	belongs to the aldehyde dehydrogenase family
CYCME_RS10415	COG0745	RESPONSE REGULATOR receiver
CYCME_RS10425	COG0784	Response regulator, receiver
CYCME_RS10435	COG3447	MASE1 domain protein
CYCME_RS10435	COG5001	Diguanylate cyclase
CYCME_RS10435	COG5002	protein histidine kinase activity
CYCME_RS10445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYCME_RS10450	COG3243	poly(R)-hydroxyalkanoic acid synthase
CYCME_RS10465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CYCME_RS10470	COG1518	maintenance of DNA repeat elements
CYCME_RS10485	COG1857	crispr-associated protein
CYCME_RS10500	COG1203	CRISPR-associated helicase, Cas3
CYCME_RS10505	COG3550	peptidyl-serine autophosphorylation
CYCME_RS10510	COG1396	sequence-specific DNA binding
CYCME_RS10520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CYCME_RS10525	COG0602	queuosine metabolic process
CYCME_RS10530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CYCME_RS10535	COG2885	chlorophyll binding
CYCME_RS10540	COG0823	Involved in the tonB-independent uptake of proteins
CYCME_RS10560	COG0824	Thioesterase
CYCME_RS10565	COG2255	four-way junction helicase activity
CYCME_RS10570	COG0632	four-way junction helicase activity
CYCME_RS10585	COG1902	pentaerythritol trinitrate reductase activity
CYCME_RS10590	COG0459	protein refolding
CYCME_RS10595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYCME_RS10600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYCME_RS10630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CYCME_RS10645	COG0535	radical SAM domain protein
CYCME_RS10650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CYCME_RS10675	COG3437	response regulator, receiver
CYCME_RS10680	COG2202	Pas domain
CYCME_RS10680	COG2205	protein histidine kinase activity
CYCME_RS10685	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CYCME_RS10690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYCME_RS10695	COG0071	Belongs to the small heat shock protein (HSP20) family
CYCME_RS10710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYCME_RS10715	COG3012	SEC-C Motif Domain Protein
CYCME_RS10735	COG0047	phosphoribosylformylglycinamidine synthase activity
CYCME_RS10735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYCME_RS10740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYCME_RS10750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYCME_RS10755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYCME_RS10790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYCME_RS10795	COG1428	Deoxynucleoside kinase
CYCME_RS10800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYCME_RS10805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYCME_RS10810	COG0668	transmembrane transport
CYCME_RS10815	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CYCME_RS10820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYCME_RS10820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYCME_RS10835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CYCME_RS10840	COG2096	Adenosyltransferase
CYCME_RS10850	COG0183	Belongs to the thiolase family
CYCME_RS10875	COG3243	poly(R)-hydroxyalkanoic acid synthase
CYCME_RS10895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYCME_RS10900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CYCME_RS10905	COG2920	part of a sulfur-relay system
CYCME_RS10920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CYCME_RS10925	COG4783	chaperone-mediated protein folding
CYCME_RS10935	COG0795	lipopolysaccharide-transporting ATPase activity
CYCME_RS10940	COG0795	lipopolysaccharide-transporting ATPase activity
CYCME_RS10945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYCME_RS10955	COG0525	valine-tRNA ligase activity
CYCME_RS10965	COG0463	Glycosyl transferase, family 2
CYCME_RS10970	COG0438	transferase activity, transferring glycosyl groups
CYCME_RS10975	COG2226	methyltransferase
CYCME_RS10985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYCME_RS10995	COG0438	transferase activity, transferring glycosyl groups
CYCME_RS11040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CYCME_RS11045	COG0237	dephospho-CoA kinase activity
CYCME_RS11050	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CYCME_RS11055	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CYCME_RS11060	COG0494	nUDIX hydrolase
CYCME_RS11065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYCME_RS11070	COG0653	protein targeting
CYCME_RS11075	COG0739	heme binding
CYCME_RS11075	COG1196	nuclear chromosome segregation
CYCME_RS11075	COG0741	lytic transglycosylase activity
CYCME_RS11085	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CYCME_RS11090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYCME_RS11100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CYCME_RS11105	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYCME_RS11110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYCME_RS11115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYCME_RS11120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYCME_RS11125	COG0772	Belongs to the SEDS family
CYCME_RS11130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYCME_RS11135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYCME_RS11140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CYCME_RS11155	COG3116	cell division
CYCME_RS11160	COG0275	rRNA processing
CYCME_RS11165	COG2001	Belongs to the MraZ family
CYCME_RS11180	COG1294	oxidase, subunit
CYCME_RS11185	COG1271	oxidase subunit
CYCME_RS11195	COG0848	biopolymer transport protein
CYCME_RS11210	COG4774	siderophore transport
CYCME_RS11220	COG3128	pkhd-type hydroxylase
CYCME_RS11230	COG1278	Cold shock
CYCME_RS11240	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYCME_RS11295	COG0012	GTP binding
CYCME_RS11300	COG0473	3-isopropylmalate dehydrogenase activity
CYCME_RS11310	COG0066	3-isopropylmalate dehydratase activity
CYCME_RS11315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYCME_RS11380	COG3396	Phenylacetate-CoA oxygenase
CYCME_RS11390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CYCME_RS11395	COG0318	PFAM AMP-dependent synthetase and ligase
CYCME_RS11405	COG2855	membrane
CYCME_RS11420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CYCME_RS11425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CYCME_RS11425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CYCME_RS11435	COG1360	Flagellar Motor Protein
CYCME_RS11440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CYCME_RS11445	COG0306	phosphate transporter
CYCME_RS11450	COG1392	Phosphate transport regulator
CYCME_RS11460	COG3746	phosphate-selective porin O and P
CYCME_RS11470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYCME_RS11480	COG0573	inorganic phosphate transmembrane transporter activity
CYCME_RS11485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYCME_RS11505	COG0542	response to heat
CYCME_RS11510	COG0428	transporter
CYCME_RS11520	COG0564	pseudouridine synthase activity
CYCME_RS11530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYCME_RS11530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYCME_RS11535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CYCME_RS11540	COG0045	succinate-CoA ligase (ADP-forming) activity
CYCME_RS11565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CYCME_RS11570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYCME_RS11580	COG0418	dihydroorotase activity
CYCME_RS11585	COG2853	Lipoprotein
CYCME_RS11595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CYCME_RS11605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYCME_RS11610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYCME_RS11620	COG0129	dihydroxy-acid dehydratase activity
CYCME_RS11640	COG0494	nUDIX hydrolase
CYCME_RS11650	COG0519	Catalyzes the synthesis of GMP from XMP
CYCME_RS11655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYCME_RS11655	COG1648	precorrin-2 dehydrogenase activity
CYCME_RS11660	COG0596	Alpha beta hydrolase
CYCME_RS11675	COG2885	chlorophyll binding
CYCME_RS11675	COG3047	cAMP biosynthetic process
CYCME_RS11685	COG0318	PFAM AMP-dependent synthetase and ligase
CYCME_RS11690	COG1960	acyl-CoA dehydrogenase activity
CYCME_RS11705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CYCME_RS11710	COG0372	Belongs to the citrate synthase family
CYCME_RS11715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CYCME_RS11750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYCME_RS11765	COG0316	Belongs to the HesB IscA family
CYCME_RS11780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYCME_RS11795	COG1981	membrane
CYCME_RS11800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CYCME_RS11805	COG0316	Belongs to the HesB IscA family
CYCME_RS11810	COG1730	sister chromatid segregation
CYCME_RS11835	COG0471	metal ion transport
CYCME_RS11835	COG0471	metal ion transport
CYCME_RS11860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CYCME_RS11865	COG1388	LysM domain
CYCME_RS11865	COG0741	lytic transglycosylase activity
CYCME_RS11885	COG4221	oxidoreductase activity
CYCME_RS11895	COG2814	Major facilitator Superfamily
CYCME_RS11920	COG2204	response regulator
CYCME_RS11925	COG0442	prolyl-tRNA aminoacylation
CYCME_RS11930	COG0500	methyltransferase
CYCME_RS11945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CYCME_RS11970	COG1074	ATP-dependent DNA helicase activity
CYCME_RS12005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CYCME_RS12080	COG1573	uracil-dna glycosylase
CYCME_RS12085	COG1183	phosphatidylcholine synthase activity
CYCME_RS12090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYCME_RS12095	COG0440	acetolactate synthase activity
CYCME_RS12100	COG0028	Belongs to the TPP enzyme family
CYCME_RS12115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYCME_RS12120	COG1333	cytochrome c biogenesis protein
CYCME_RS12155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CYCME_RS12255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYCME_RS12270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYCME_RS12275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYCME_RS12280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYCME_RS12285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYCME_RS12290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYCME_RS12295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYCME_RS12300	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYCME_RS12305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYCME_RS12315	COG0356	it plays a direct role in the translocation of protons across the membrane
CYCME_RS12325	COG1475	DNA binding
CYCME_RS12330	COG1192	Involved in chromosome partitioning
CYCME_RS12335	COG0357	Ribosomal RNA small subunit methyltransferase G
CYCME_RS12340	COG0445	tRNA wobble uridine modification
CYCME_RS12345	COG0714	Associated with various cellular activities
CYCME_RS12375	COG0133	tryptophan synthase activity
CYCME_RS12380	COG2346	COG2346, Truncated hemoglobins
CYCME_RS12385	COG0346	lactoylglutathione lyase activity
CYCME_RS12400	COG4638	Rieske (2fe-2S)
CYCME_RS12415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CYCME_RS12420	COG4638	Rieske (2fe-2S)
CYCME_RS12425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYCME_RS12460	COG2409	Drug exporters of the RND superfamily
CYCME_RS12490	COG1028	Short-chain dehydrogenase reductase Sdr
CYCME_RS12520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYCME_RS12525	COG0706	membrane insertase activity
CYCME_RS12530	COG0594	ribonuclease P activity
CYCME_RS12580	COG0187	DNA topoisomerase II activity
CYCME_RS12635	COG0804	urea catabolic process
CYCME_RS12805	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CYCME_RS12810	COG0517	IMP dehydrogenase activity
CYCME_RS12820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYCME_RS12830	COG2188	Transcriptional regulator