locus-tag	class	description
CBDB_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CBDB_RS00020	COG0187	DNA topoisomerase II activity
CBDB_RS00025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CBDB_RS00045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBDB_RS00125	COG0569	domain protein
CBDB_RS00135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBDB_RS00140	COG0569	domain protein
CBDB_RS00155	COG0306	phosphate transporter
CBDB_RS00170	COG0543	2 iron, 2 sulfur cluster binding
CBDB_RS00175	COG0493	'glutamate synthase
CBDB_RS00190	COG2226	methyltransferase
CBDB_RS00210	COG0012	GTP binding
CBDB_RS00250	COG1979	alcohol dehydrogenase
CBDB_RS00265	COG0542	response to heat
CBDB_RS00270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CBDB_RS00295	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00320	COG2205	protein histidine kinase activity
CBDB_RS00325	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00365	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00370	COG2205	protein histidine kinase activity
CBDB_RS00415	COG2197	response regulator
CBDB_RS00420	COG1396	sequence-specific DNA binding
CBDB_RS00460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CBDB_RS00470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CBDB_RS00480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CBDB_RS00525	COG1307	EDD domain protein, DegV family
CBDB_RS00530	COG1704	LemA family
CBDB_RS00540	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CBDB_RS00555	COG0437	4 iron, 4 sulfur cluster binding
CBDB_RS00580	COG0693	protein deglycase activity
CBDB_RS00585	COG0511	ligase activity, forming carbon-carbon bonds
CBDB_RS00585	COG5016	pyruvate
CBDB_RS00590	COG0439	Biotin carboxylase
CBDB_RS00600	COG0493	'glutamate synthase
CBDB_RS00605	COG1063	alcohol dehydrogenase
CBDB_RS00625	COG0432	Pfam Uncharacterised protein family UPF0047
CBDB_RS00630	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00635	COG2204	response regulator
CBDB_RS00655	COG4968	Prepilin-type N-terminal cleavage methylation domain
CBDB_RS00660	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00665	COG5002	protein histidine kinase activity
CBDB_RS00670	COG1803	Methylglyoxal synthase
CBDB_RS00675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CBDB_RS00680	COG0573	inorganic phosphate transmembrane transporter activity
CBDB_RS00685	COG0581	inorganic phosphate transmembrane transporter activity
CBDB_RS00695	COG0704	Plays a role in the regulation of phosphate uptake
CBDB_RS00725	COG2267	carboxylic ester hydrolase activity
CBDB_RS00770	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00775	COG5002	protein histidine kinase activity
CBDB_RS00800	COG0513	Belongs to the DEAD box helicase family
CBDB_RS00815	COG5557	Pfam Polysulphide reductase, NrfD
CBDB_RS00825	COG0742	ribosomal rna small subunit methyltransferase
CBDB_RS00835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CBDB_RS00855	COG2081	HI0933 family
CBDB_RS00860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CBDB_RS00860	COG0456	acetyltransferase
CBDB_RS00890	COG0363	glucosamine-6-phosphate deaminase activity
CBDB_RS00895	COG0667	Aldo Keto reductase
CBDB_RS00925	COG0488	(ABC) transporter
CBDB_RS00935	COG2081	HI0933 family
CBDB_RS00955	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00960	COG2205	protein histidine kinase activity
CBDB_RS00980	COG0745	RESPONSE REGULATOR receiver
CBDB_RS00985	COG2205	protein histidine kinase activity
CBDB_RS01045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CBDB_RS01060	COG1104	cysteine desulfurase activity
CBDB_RS01070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBDB_RS01095	COG1752	Esterase of the alpha-beta hydrolase superfamily
CBDB_RS01125	COG0123	including yeast histone deacetylase and acetoin utilization protein
CBDB_RS01135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBDB_RS01140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBDB_RS01145	COG0617	tRNA 3'-terminal CCA addition
CBDB_RS01155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CBDB_RS01185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CBDB_RS01205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBDB_RS01210	COG1610	YqeY-like protein
CBDB_RS01260	COG0793	Belongs to the peptidase S41A family
CBDB_RS01275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CBDB_RS01295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CBDB_RS01300	COG4589	Belongs to the CDS family
CBDB_RS01320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CBDB_RS01330	COG0047	phosphoribosylformylglycinamidine synthase activity
CBDB_RS01335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CBDB_RS01360	COG0516	GMP reductase activity
CBDB_RS01365	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CBDB_RS01380	COG0142	geranyltranstransferase activity
CBDB_RS01385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBDB_RS01395	COG0799	negative regulation of ribosome biogenesis
CBDB_RS01405	COG1214	PFAM Peptidase M22, glycoprotease
CBDB_RS01410	COG0802	atpase or kinase
CBDB_RS01415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CBDB_RS01425	COG2226	methyltransferase
CBDB_RS01430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CBDB_RS01470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CBDB_RS01475	COG3620	sequence-specific DNA binding
CBDB_RS01475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CBDB_RS01475	COG0617	tRNA 3'-terminal CCA addition
CBDB_RS01480	COG1131	(ABC) transporter
CBDB_RS01485	COG0842	Transport permease protein
CBDB_RS01500	COG1597	lipid kinase activity
CBDB_RS01515	COG1126	abc transporter atp-binding protein
CBDB_RS01520	COG0765	amino acid transport
CBDB_RS01540	COG0598	Magnesium transport protein CorA
CBDB_RS01560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CBDB_RS01560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CBDB_RS01570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CBDB_RS01600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CBDB_RS01610	COG1573	uracil-dna glycosylase
CBDB_RS01615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CBDB_RS01620	COG1674	ftsk spoiiie
CBDB_RS01650	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CBDB_RS01655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CBDB_RS01665	COG0066	3-isopropylmalate dehydratase activity
CBDB_RS01670	COG0538	isocitrate dehydrogenase activity
CBDB_RS01695	COG0537	adenosine 5'-monophosphoramidase activity
CBDB_RS01700	COG0494	nUDIX hydrolase
CBDB_RS01705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CBDB_RS01720	COG1605	Chorismate mutase
CBDB_RS01720	COG0287	Prephenate dehydrogenase
CBDB_RS01725	COG0077	Prephenate dehydratase
CBDB_RS01725	COG1605	Chorismate mutase
CBDB_RS01760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CBDB_RS01890	COG0024	Methionine aminopeptidase
CBDB_RS01965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CBDB_RS01985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CBDB_RS02000	COG1131	(ABC) transporter
CBDB_RS02030	COG0312	modulator of DNA gyrase
CBDB_RS02035	COG0312	modulator of DNA gyrase
CBDB_RS02040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBDB_RS02055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CBDB_RS02065	COG1011	Hydrolase
CBDB_RS02070	COG0019	diaminopimelate decarboxylase activity
CBDB_RS02075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CBDB_RS02080	COG1774	PSP1 C-terminal conserved region
CBDB_RS02100	COG0305	Participates in initiation and elongation during chromosome replication
CBDB_RS02110	COG0492	ferredoxin-NADP+ reductase activity
CBDB_RS02120	COG1924	4 iron, 4 sulfur cluster binding
CBDB_RS02145	COG0419	ATPase involved in DNA repair
CBDB_RS02150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CBDB_RS02160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CBDB_RS02165	COG0574	Belongs to the PEP-utilizing enzyme family
CBDB_RS02165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBDB_RS02180	COG0356	it plays a direct role in the translocation of protons across the membrane
CBDB_RS02240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CBDB_RS02250	COG2003	Belongs to the UPF0758 family
CBDB_RS02255	COG0747	negative chemotaxis
CBDB_RS02300	COG0598	Magnesium transport protein CorA
CBDB_RS02310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CBDB_RS02315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CBDB_RS02345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CBDB_RS02390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CBDB_RS02425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CBDB_RS02430	COG0456	acetyltransferase
CBDB_RS02445	COG2226	methyltransferase
CBDB_RS02455	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CBDB_RS02460	COG3259	Nickel-dependent hydrogenase
CBDB_RS02475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBDB_RS02480	COG0785	Cytochrome C biogenesis protein
CBDB_RS02525	COG1509	lysine 2,3-aminomutase activity
CBDB_RS02530	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBDB_RS02535	COG0735	belongs to the Fur family
CBDB_RS02540	COG3443	Belongs to the bacterial solute-binding protein 9 family
CBDB_RS02540	COG0803	Belongs to the bacterial solute-binding protein 9 family
CBDB_RS02545	COG1121	(ABC) transporter
CBDB_RS02550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBDB_RS02560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CBDB_RS02580	COG0589	response to stress
CBDB_RS02590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CBDB_RS02595	COG0698	ribose 5-phosphate isomerase
CBDB_RS02600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CBDB_RS02605	COG0778	Nitroreductase
CBDB_RS02610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CBDB_RS02620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBDB_RS02625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBDB_RS02630	COG1120	ATPase activity
CBDB_RS02645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBDB_RS02660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CBDB_RS02665	COG0406	alpha-ribazole phosphatase activity
CBDB_RS02670	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CBDB_RS02675	COG3118	belongs to the thioredoxin family
CBDB_RS02685	COG2197	response regulator
CBDB_RS02770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CBDB_RS02775	COG0006	proline dipeptidase activity
CBDB_RS02780	COG4974	Belongs to the 'phage' integrase family
CBDB_RS02785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CBDB_RS02790	COG0758	DNA mediated transformation
CBDB_RS02790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CBDB_RS02805	COG0475	glutathione-regulated potassium exporter activity
CBDB_RS02825	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBDB_RS02830	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBDB_RS02845	COG1034	ATP synthesis coupled electron transport
CBDB_RS02855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CBDB_RS02860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CBDB_RS02880	COG1028	Short-chain dehydrogenase reductase Sdr
CBDB_RS02885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CBDB_RS02975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CBDB_RS02990	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CBDB_RS02995	COG0126	phosphoglycerate kinase activity
CBDB_RS03015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CBDB_RS03030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CBDB_RS03060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CBDB_RS03095	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CBDB_RS03110	COG0517	IMP dehydrogenase activity
CBDB_RS03110	COG1994	Peptidase M50
CBDB_RS03115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CBDB_RS03120	COG0492	ferredoxin-NADP+ reductase activity
CBDB_RS03135	COG1994	Peptidase M50
CBDB_RS03135	COG0517	IMP dehydrogenase activity
CBDB_RS03150	COG3854	ATPases associated with a variety of cellular activities
CBDB_RS03175	COG0352	thiamine-phosphate diphosphorylase activity
CBDB_RS03185	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CBDB_RS03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBDB_RS03200	COG0423	glycine-tRNA ligase activity
CBDB_RS03205	COG0420	3'-5' exonuclease activity
CBDB_RS03210	COG1187	pseudouridine synthase activity
CBDB_RS03225	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CBDB_RS03235	COG1131	(ABC) transporter
CBDB_RS03285	COG1695	Transcriptional regulator
CBDB_RS03320	COG1131	(ABC) transporter
CBDB_RS03325	COG0842	Transport permease protein
CBDB_RS03330	COG0396	ATPase activity
CBDB_RS03335	COG0719	Fe-S assembly protein
CBDB_RS03340	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CBDB_RS03380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CBDB_RS03390	COG0066	3-isopropylmalate dehydratase activity
CBDB_RS03395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CBDB_RS03400	COG1285	pathogenesis
CBDB_RS03405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CBDB_RS03420	COG0028	Belongs to the TPP enzyme family
CBDB_RS03430	COG0009	L-threonylcarbamoyladenylate synthase
CBDB_RS03445	COG0151	Belongs to the GarS family
CBDB_RS03450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CBDB_RS03455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CBDB_RS03460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CBDB_RS03480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CBDB_RS03495	COG0330	HflC and HflK could
CBDB_RS03510	COG4152	abc transporter atp-binding protein
CBDB_RS03540	COG1136	(ABC) transporter
CBDB_RS03540	COG0577	efflux transmembrane transporter activity
CBDB_RS03545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBDB_RS03555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CBDB_RS03555	COG2111	Na H antiporter
CBDB_RS03560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CBDB_RS03565	COG3260	NADH ubiquinone oxidoreductase 20
CBDB_RS03585	COG0493	'glutamate synthase
CBDB_RS03585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CBDB_RS03595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBDB_RS03600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CBDB_RS03605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CBDB_RS03610	COG1846	Transcriptional regulator
CBDB_RS03615	COG2409	Drug exporters of the RND superfamily
CBDB_RS03615	COG1033	growth of symbiont in host cell
CBDB_RS03635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBDB_RS03705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBDB_RS03730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBDB_RS03745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CBDB_RS03750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBDB_RS03760	COG0084	hydrolase, TatD family'
CBDB_RS03765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBDB_RS03790	COG0318	PFAM AMP-dependent synthetase and ligase
CBDB_RS03820	COG0318	PFAM AMP-dependent synthetase and ligase
CBDB_RS03845	COG0822	iron-sulfur transferase activity
CBDB_RS03855	COG2217	Heavy metal translocating P-type atpase
CBDB_RS03860	COG0071	Belongs to the small heat shock protein (HSP20) family
CBDB_RS03895	COG0107	imidazoleglycerol-phosphate synthase activity
CBDB_RS03905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBDB_RS03910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBDB_RS03915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBDB_RS03915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBDB_RS03930	COG1111	helicase
CBDB_RS03930	COG1205	dead DEAH box helicase
CBDB_RS03955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CBDB_RS03980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBDB_RS03985	COG0438	transferase activity, transferring glycosyl groups
CBDB_RS03990	COG1260	myo-inositol-1-phosphate synthase
CBDB_RS04015	COG0195	Participates in both transcription termination and antitermination
CBDB_RS04020	COG0606	chelatase, subunit chli
CBDB_RS04060	COG0250	Participates in transcription elongation, termination and antitermination
CBDB_RS04065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CBDB_RS04125	COG2211	Major facilitator Superfamily
CBDB_RS04160	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CBDB_RS04220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBDB_RS04225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CBDB_RS04230	COG1307	EDD domain protein, DegV family
CBDB_RS04235	COG0318	PFAM AMP-dependent synthetase and ligase
CBDB_RS04240	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CBDB_RS04245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBDB_RS04250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBDB_RS04260	COG1847	R3H domain protein
CBDB_RS04265	COG0706	membrane insertase activity
CBDB_RS04285	COG0629	single-stranded DNA binding
CBDB_RS04310	COG0251	oxidation-reduction process
CBDB_RS04325	COG0497	DNA recombination
CBDB_RS04330	COG0697	spore germination
CBDB_RS04345	COG2205	protein histidine kinase activity
CBDB_RS04350	COG4608	Belongs to the ABC transporter superfamily
CBDB_RS04355	COG0444	Belongs to the ABC transporter superfamily
CBDB_RS04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBDB_RS04365	COG0601	transmembrane transport
CBDB_RS04370	COG4166	transmembrane transport
CBDB_RS04375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CBDB_RS04380	COG2197	response regulator
CBDB_RS04390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CBDB_RS04410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CBDB_RS04410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBDB_RS04415	COG0174	glutamine synthetase
CBDB_RS04425	COG0004	ammonium transporteR
CBDB_RS04430	COG0745	RESPONSE REGULATOR receiver
CBDB_RS04440	COG0069	glutamate synthase activity
CBDB_RS04450	COG0067	glutamate synthase
CBDB_RS04455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CBDB_RS04465	COG0493	'glutamate synthase
CBDB_RS04465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CBDB_RS04495	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CBDB_RS04500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBDB_RS04505	COG0726	polysaccharide deacetylase
CBDB_RS04530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBDB_RS04530	COG1042	CoA-binding domain protein
CBDB_RS04530	COG0045	succinate-CoA ligase (ADP-forming) activity
CBDB_RS04540	COG0735	belongs to the Fur family
CBDB_RS04565	COG1132	(ABC) transporter
CBDB_RS04610	COG1268	BioY protein
CBDB_RS04630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBDB_RS04630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBDB_RS04640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBDB_RS04640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBDB_RS04645	COG2968	Membrane
CBDB_RS04650	COG0681	Belongs to the peptidase S26 family
CBDB_RS04655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CBDB_RS04665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBDB_RS04670	COG0210	DNA helicase
CBDB_RS04690	COG0505	Belongs to the CarA family
CBDB_RS04695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBDB_RS04700	COG0543	2 iron, 2 sulfur cluster binding
CBDB_RS04710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CBDB_RS04715	COG0460	homoserine dehydrogenase
CBDB_RS04730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CBDB_RS04740	COG2890	protein-(glutamine-N5) methyltransferase activity
CBDB_RS04745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBDB_RS04760	COG4974	Belongs to the 'phage' integrase family
CBDB_RS04775	COG0561	phosphatase activity
CBDB_RS04795	COG0179	Fumarylacetoacetate (FAA) hydrolase
CBDB_RS04800	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CBDB_RS04805	COG1980	fructose-bisphosphate aldolase activity
CBDB_RS04810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CBDB_RS04815	COG0592	DNA-directed DNA polymerase activity
CBDB_RS04865	COG0788	formyltetrahydrofolate deformylase activity
CBDB_RS04875	COG0798	PFAM Bile acid sodium symporter
CBDB_RS04885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBDB_RS04890	COG0655	NAD(P)H dehydrogenase (quinone) activity
CBDB_RS04905	COG0640	Transcriptional regulator
CBDB_RS04920	COG0431	NADPH-dependent FMN reductase
CBDB_RS04950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBDB_RS04970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CBDB_RS04980	COG1307	EDD domain protein, DegV family
CBDB_RS04985	COG1307	EDD domain protein, DegV family
CBDB_RS04990	COG1307	EDD domain protein, DegV family
CBDB_RS04995	COG1307	EDD domain protein, DegV family
CBDB_RS05000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CBDB_RS05005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CBDB_RS05020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CBDB_RS05040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CBDB_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
CBDB_RS05060	COG1032	radical SAM domain protein
CBDB_RS05065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CBDB_RS05085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBDB_RS05090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBDB_RS05095	COG0789	Transcriptional regulator
CBDB_RS05115	COG1058	Belongs to the CinA family
CBDB_RS05115	COG1546	Belongs to the CinA family
CBDB_RS05135	COG0745	RESPONSE REGULATOR receiver
CBDB_RS05150	COG1217	gtp-binding protein TYPA
CBDB_RS05170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CBDB_RS05190	COG3422	double-strand break repair
CBDB_RS05200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CBDB_RS05215	COG2078	PFAM AMMECR1 domain protein
CBDB_RS05215	COG3885	ferrous iron binding
CBDB_RS05285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBDB_RS05305	COG3872	metal-dependent enzyme
CBDB_RS05310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CBDB_RS05310	COG0140	phosphoribosyl-ATP diphosphatase activity
CBDB_RS05370	COG1522	sequence-specific DNA binding
CBDB_RS05375	COG0436	Aminotransferase
CBDB_RS05380	COG0180	Tryptophanyl-tRNA synthetase
CBDB_RS05405	COG1595	DNA-templated transcription, initiation
CBDB_RS05415	COG2197	response regulator
CBDB_RS05420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CBDB_RS05425	COG1459	type II secretion system
CBDB_RS05470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CBDB_RS05475	COG3769	mannosylglycerate metabolic process
CBDB_RS05515	COG0167	dihydroorotate dehydrogenase activity
CBDB_RS05530	COG0564	pseudouridine synthase activity
CBDB_RS05555	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CBDB_RS05555	COG2199	diguanylate cyclase activity
CBDB_RS05565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CBDB_RS05570	COG1862	Preprotein translocase
CBDB_RS05595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CBDB_RS05600	COG0671	phosphoesterase, PA-phosphatase related
CBDB_RS05605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBDB_RS05605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBDB_RS05610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CBDB_RS05625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CBDB_RS05630	COG1160	GTP binding
CBDB_RS05645	COG0484	heat shock protein binding
CBDB_RS05685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CBDB_RS05690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CBDB_RS05700	COG0484	heat shock protein binding
CBDB_RS05705	COG0789	Transcriptional regulator
CBDB_RS05710	COG0542	response to heat
CBDB_RS05720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CBDB_RS05750	COG2226	methyltransferase
CBDB_RS05760	COG0406	alpha-ribazole phosphatase activity
CBDB_RS05775	COG1253	flavin adenine dinucleotide binding
CBDB_RS05785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CBDB_RS05795	COG0612	Peptidase, M16
CBDB_RS05810	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CBDB_RS05815	COG0298	carbon dioxide binding
CBDB_RS05830	COG1309	transcriptional regulator
CBDB_RS05875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBDB_RS05890	COG2095	MarC family integral membrane protein
CBDB_RS05930	COG1040	competence protein
CBDB_RS05935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CBDB_RS05940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBDB_RS05950	COG2003	Belongs to the UPF0758 family
CBDB_RS06005	COG0512	Glutamine amidotransferase of anthranilate synthase
CBDB_RS06010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CBDB_RS06025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CBDB_RS06030	COG0133	tryptophan synthase activity
CBDB_RS06035	COG0159	tryptophan synthase activity
CBDB_RS06070	COG4608	Belongs to the ABC transporter superfamily
CBDB_RS06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBDB_RS06085	COG0601	transmembrane transport
CBDB_RS06090	COG4166	transmembrane transport
CBDB_RS06125	COG2814	Major facilitator Superfamily
CBDB_RS06130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBDB_RS06140	COG0735	belongs to the Fur family
CBDB_RS06175	COG1475	DNA binding
CBDB_RS06195	COG2963	transposase activity
CBDB_RS06200	COG2801	Transposase and inactivated derivatives
CBDB_RS06225	COG2205	protein histidine kinase activity
CBDB_RS06225	COG2202	Pas domain
CBDB_RS06230	COG0745	RESPONSE REGULATOR receiver
CBDB_RS06255	COG5002	protein histidine kinase activity
CBDB_RS06260	COG0745	RESPONSE REGULATOR receiver
CBDB_RS06345	COG0745	RESPONSE REGULATOR receiver
CBDB_RS06360	COG1598	PFAM Uncharacterised protein family UPF0150
CBDB_RS06385	COG1857	crispr-associated protein
CBDB_RS06430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBDB_RS06495	COG2205	protein histidine kinase activity
CBDB_RS06500	COG0745	RESPONSE REGULATOR receiver
CBDB_RS06515	COG4585	Histidine kinase
CBDB_RS06520	COG2197	response regulator
CBDB_RS06535	COG0745	RESPONSE REGULATOR receiver
CBDB_RS06545	COG1846	Transcriptional regulator
CBDB_RS06595	COG2205	protein histidine kinase activity
CBDB_RS06620	COG0174	glutamine synthetase
CBDB_RS06725	COG0745	RESPONSE REGULATOR receiver
CBDB_RS06735	COG0745	RESPONSE REGULATOR receiver
CBDB_RS06735	COG2205	protein histidine kinase activity
CBDB_RS06735	COG4191	Histidine kinase
CBDB_RS06800	COG1584	GPR1 FUN34 yaaH family protein
CBDB_RS06805	COG4191	Histidine kinase
CBDB_RS06825	COG1132	(ABC) transporter
CBDB_RS06830	COG1032	radical SAM domain protein
CBDB_RS06835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CBDB_RS06840	COG1846	Transcriptional regulator
CBDB_RS06865	COG0477	Major facilitator Superfamily
CBDB_RS06870	COG1846	Transcriptional regulator
CBDB_RS06885	COG1846	Transcriptional regulator
CBDB_RS06900	COG2202	Pas domain
CBDB_RS06900	COG2205	protein histidine kinase activity
CBDB_RS06985	COG3260	NADH ubiquinone oxidoreductase 20
CBDB_RS06990	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CBDB_RS06990	COG3261	NADH dehydrogenase
CBDB_RS06995	COG0651	ATP synthesis coupled electron transport
CBDB_RS07005	COG0650	Formate hydrogenlyase subunit 4
CBDB_RS07010	COG0651	ATP synthesis coupled electron transport
CBDB_RS07015	COG1803	Methylglyoxal synthase
CBDB_RS07025	COG0668	transmembrane transport
CBDB_RS07035	COG0702	epimerase
CBDB_RS07045	COG0450	alkyl hydroperoxide reductase
CBDB_RS07070	COG1704	LemA family
CBDB_RS07075	COG0501	Belongs to the peptidase M48B family
CBDB_RS07080	COG1045	serine acetyltransferase
CBDB_RS07095	COG2226	methyltransferase
CBDB_RS07105	COG1959	2 iron, 2 sulfur cluster binding
CBDB_RS07125	COG0805	protein transport
CBDB_RS07130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBDB_RS07135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBDB_RS07145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CBDB_RS07160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CBDB_RS07165	COG2137	regulation of response to DNA damage stimulus
CBDB_RS07175	COG1692	metallophosphoesterase
CBDB_RS07180	COG0613	PHP domain protein
CBDB_RS07195	COG1720	tRNA m6t6A37 methyltransferase activity
CBDB_RS07225	COG1131	(ABC) transporter
CBDB_RS07230	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CBDB_RS07265	COG4651	solute:proton antiporter activity
CBDB_RS07265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CBDB_RS07270	COG1234	tRNA 3'-trailer cleavage
CBDB_RS07280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CBDB_RS07290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CBDB_RS07305	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CBDB_RS07315	COG3956	TIGRFAM MazG family protein
CBDB_RS07320	COG2738	Putative neutral zinc metallopeptidase
CBDB_RS07330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CBDB_RS07365	COG2205	protein histidine kinase activity