locus-tag	class	description
B1774_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1774_RS00010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1774_RS00015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1774_RS00020	COG0187	DNA topoisomerase II activity
B1774_RS00025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1774_RS00030	COG0124	histidyl-tRNA synthetase
B1774_RS00040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1774_RS00045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1774_RS00050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1774_RS00060	COG0284	orotidine-5'-phosphate decarboxylase activity
B1774_RS00090	COG1490	D-aminoacyl-tRNA deacylase activity
B1774_RS00110	COG0658	competence protein
B1774_RS00110	COG2333	competence protein COMEC
B1774_RS00115	COG3568	Endonuclease Exonuclease Phosphatase
B1774_RS00115	COG1555	photosystem II stabilization
B1774_RS00125	COG0569	domain protein
B1774_RS00135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1774_RS00140	COG0569	domain protein
B1774_RS00155	COG0306	phosphate transporter
B1774_RS00160	COG0194	GDP metabolic process
B1774_RS00170	COG0543	2 iron, 2 sulfur cluster binding
B1774_RS00175	COG0493	'glutamate synthase
B1774_RS00190	COG2226	methyltransferase
B1774_RS00210	COG0012	GTP binding
B1774_RS00235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1774_RS00240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1774_RS00245	COG0343	queuine tRNA-ribosyltransferase activity
B1774_RS00250	COG1979	alcohol dehydrogenase
B1774_RS00265	COG0542	response to heat
B1774_RS00270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B1774_RS00275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1774_RS00280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1774_RS00285	COG0215	cysteine-tRNA ligase activity
B1774_RS00295	COG4974	Belongs to the 'phage' integrase family
B1774_RS00320	COG4974	Belongs to the 'phage' integrase family
B1774_RS00405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B1774_RS00425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B1774_RS00425	COG1918	ferrous iron import across plasma membrane
B1774_RS00435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B1774_RS00435	COG1918	ferrous iron import across plasma membrane
B1774_RS00445	COG0746	molybdenum cofactor guanylyltransferase activity
B1774_RS00480	COG1307	EDD domain protein, DegV family
B1774_RS00485	COG1704	LemA family
B1774_RS00495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B1774_RS00510	COG0437	4 iron, 4 sulfur cluster binding
B1774_RS00535	COG0693	protein deglycase activity
B1774_RS00540	COG0511	ligase activity, forming carbon-carbon bonds
B1774_RS00540	COG5016	pyruvate
B1774_RS00545	COG0439	Biotin carboxylase
B1774_RS00555	COG0493	'glutamate synthase
B1774_RS00560	COG1063	alcohol dehydrogenase
B1774_RS00565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1774_RS00575	COG1797	cobyrinic acid a,c-diamide synthase activity
B1774_RS00580	COG0432	Pfam Uncharacterised protein family UPF0047
B1774_RS00585	COG0745	RESPONSE REGULATOR receiver
B1774_RS00590	COG2204	response regulator
B1774_RS00605	COG4968	Prepilin-type N-terminal cleavage methylation domain
B1774_RS00610	COG0745	RESPONSE REGULATOR receiver
B1774_RS00615	COG5002	protein histidine kinase activity
B1774_RS00620	COG1803	Methylglyoxal synthase
B1774_RS00630	COG0573	inorganic phosphate transmembrane transporter activity
B1774_RS00635	COG0581	inorganic phosphate transmembrane transporter activity
B1774_RS00640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1774_RS00645	COG0704	Plays a role in the regulation of phosphate uptake
B1774_RS00680	COG2267	carboxylic ester hydrolase activity
B1774_RS00715	COG2205	protein histidine kinase activity
B1774_RS00735	COG0513	Belongs to the DEAD box helicase family
B1774_RS00750	COG5557	Pfam Polysulphide reductase, NrfD
B1774_RS00760	COG0742	ribosomal rna small subunit methyltransferase
B1774_RS00765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1774_RS00770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1774_RS00785	COG0495	leucyl-tRNA aminoacylation
B1774_RS00790	COG2081	HI0933 family
B1774_RS00820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B1774_RS00825	COG1216	Glycosyl transferase, family 2
B1774_RS00825	COG0463	Glycosyl transferase, family 2
B1774_RS00835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1774_RS00840	COG0083	homoserine kinase activity
B1774_RS00845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1774_RS00860	COG0463	Glycosyl transferase, family 2
B1774_RS00890	COG0363	glucosamine-6-phosphate deaminase activity
B1774_RS00895	COG0667	Aldo Keto reductase
B1774_RS00900	COG1342	Belongs to the UPF0251 family
B1774_RS00925	COG0488	(ABC) transporter
B1774_RS00935	COG2081	HI0933 family
B1774_RS01015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1774_RS01025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1774_RS01050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B1774_RS01060	COG0513	Belongs to the DEAD box helicase family
B1774_RS01115	COG1752	Esterase of the alpha-beta hydrolase superfamily
B1774_RS01140	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1774_RS01150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1774_RS01155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1774_RS01170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1774_RS01175	COG0335	large ribosomal subunit rRNA binding
B1774_RS01180	COG0336	Belongs to the RNA methyltransferase TrmD family
B1774_RS01185	COG2001	Belongs to the MraZ family
B1774_RS01190	COG0275	rRNA processing
B1774_RS01200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1774_RS01205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1774_RS01220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1774_RS01225	COG1610	YqeY-like protein
B1774_RS01315	COG0793	Belongs to the peptidase S41A family
B1774_RS01320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1774_RS01325	COG0072	phenylalanine-tRNA ligase activity
B1774_RS01325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1774_RS01330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B1774_RS01335	COG0442	prolyl-tRNA aminoacylation
B1774_RS01350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1774_RS01355	COG4589	Belongs to the CDS family
B1774_RS01365	COG0233	cytoplasmic translational termination
B1774_RS01370	COG0528	UMP kinase activity
B1774_RS01375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1774_RS01380	COG0052	Belongs to the universal ribosomal protein uS2 family
B1774_RS01385	COG0047	phosphoribosylformylglycinamidine synthase activity
B1774_RS01390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1774_RS01395	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B1774_RS01415	COG0516	GMP reductase activity
B1774_RS01420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B1774_RS01430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1774_RS01435	COG0142	geranyltranstransferase activity
B1774_RS01440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1774_RS01450	COG0799	negative regulation of ribosome biogenesis
B1774_RS01455	COG0105	UTP biosynthetic process
B1774_RS01460	COG1214	PFAM Peptidase M22, glycoprotease
B1774_RS01465	COG0802	atpase or kinase
B1774_RS01470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B1774_RS01475	COG2226	methyltransferase
B1774_RS01480	COG2226	methyltransferase
B1774_RS01485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1774_RS01495	COG2226	methyltransferase
B1774_RS01505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1774_RS01510	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1774_RS01525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1774_RS01530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B1774_RS01530	COG3620	sequence-specific DNA binding
B1774_RS01530	COG0617	tRNA 3'-terminal CCA addition
B1774_RS01535	COG1131	(ABC) transporter
B1774_RS01540	COG0842	Transport permease protein
B1774_RS01555	COG1597	lipid kinase activity
B1774_RS01570	COG1126	abc transporter atp-binding protein
B1774_RS01575	COG0765	amino acid transport
B1774_RS01600	COG0598	Magnesium transport protein CorA
B1774_RS01615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B1774_RS01615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1774_RS01620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1774_RS01625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1774_RS01630	COG0525	valine-tRNA ligase activity
B1774_RS01650	COG0653	protein targeting
B1774_RS01655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1774_RS01660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1774_RS01665	COG1573	uracil-dna glycosylase
B1774_RS01670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B1774_RS01675	COG1674	ftsk spoiiie
B1774_RS01680	COG0556	nucleotide-excision repair
B1774_RS01685	COG0632	four-way junction helicase activity
B1774_RS01690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1774_RS01695	COG0217	transcriptional regulatory protein
B1774_RS01700	COG0736	holo-[acyl-carrier-protein] synthase activity
B1774_RS01705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B1774_RS01710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1774_RS01720	COG0066	3-isopropylmalate dehydratase activity
B1774_RS01725	COG0473	3-isopropylmalate dehydrogenase activity
B1774_RS01730	COG0039	L-malate dehydrogenase activity
B1774_RS01750	COG0537	adenosine 5'-monophosphoramidase activity
B1774_RS01760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1774_RS01765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1774_RS01775	COG1605	Chorismate mutase
B1774_RS01775	COG0287	Prephenate dehydrogenase
B1774_RS01780	COG0077	Prephenate dehydratase
B1774_RS01780	COG1605	Chorismate mutase
B1774_RS01785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1774_RS01790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1774_RS01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1774_RS01800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1774_RS01805	COG0710	3-dehydroquinate dehydratase activity
B1774_RS01810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1774_RS01815	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B1774_RS01820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1774_RS01830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1774_RS01835	COG0051	transcription antitermination factor activity, RNA binding
B1774_RS01840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1774_RS01845	COG0088	Forms part of the polypeptide exit tunnel
B1774_RS01850	COG0089	rRNA binding
B1774_RS01950	COG0024	Methionine aminopeptidase
B1774_RS01980	COG0202	RNA polymerase activity
B1774_RS01985	COG0203	ribosomal protein L17
B1774_RS01995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1774_RS02000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1774_RS02015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1774_RS02025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1774_RS02030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1774_RS02050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B1774_RS02055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B1774_RS02070	COG2030	dehydratase
B1774_RS02095	COG0312	modulator of DNA gyrase
B1774_RS02100	COG0312	modulator of DNA gyrase
B1774_RS02105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1774_RS02115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1774_RS02120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1774_RS02130	COG1011	Hydrolase
B1774_RS02135	COG0019	diaminopimelate decarboxylase activity
B1774_RS02140	COG0470	DNA polymerase III
B1774_RS02145	COG1774	PSP1 C-terminal conserved region
B1774_RS02165	COG0305	Participates in initiation and elongation during chromosome replication
B1774_RS02170	COG0359	binds to the 23S rRNA
B1774_RS02175	COG0492	ferredoxin-NADP+ reductase activity
B1774_RS02180	COG0416	fatty acid biosynthetic process
B1774_RS02185	COG1924	4 iron, 4 sulfur cluster binding
B1774_RS02190	COG1473	amidohydrolase
B1774_RS02210	COG0419	ATPase involved in DNA repair
B1774_RS02215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1774_RS02220	COG0358	DNA primase activity
B1774_RS02225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1774_RS02230	COG0574	Belongs to the PEP-utilizing enzyme family
B1774_RS02230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1774_RS02245	COG0356	it plays a direct role in the translocation of protons across the membrane
B1774_RS02255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1774_RS02260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1774_RS02265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1774_RS02270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1774_RS02275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1774_RS02280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1774_RS02285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1774_RS02295	COG0228	four-way junction DNA binding
B1774_RS02305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1774_RS02315	COG2003	Belongs to the UPF0758 family
B1774_RS02320	COG0747	negative chemotaxis
B1774_RS02340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1774_RS02345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1774_RS02350	COG1381	Involved in DNA repair and RecF pathway recombination
B1774_RS02360	COG0598	Magnesium transport protein CorA
B1774_RS02365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1774_RS02370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1774_RS02375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1774_RS02400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1774_RS02410	COG0148	phosphopyruvate hydratase activity
B1774_RS02420	COG0193	aminoacyl-tRNA hydrolase activity
B1774_RS02425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1774_RS02435	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B1774_RS02440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1774_RS02450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1774_RS02460	COG0085	RNA polymerase activity
B1774_RS02465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1774_RS02470	COG2255	four-way junction helicase activity
B1774_RS02475	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B1774_RS02480	COG0456	acetyltransferase
B1774_RS02495	COG2226	methyltransferase
B1774_RS02505	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
B1774_RS02510	COG3259	Nickel-dependent hydrogenase
B1774_RS02530	COG0785	Cytochrome C biogenesis protein
B1774_RS02560	COG3852	Histidine kinase
B1774_RS02575	COG1509	lysine 2,3-aminomutase activity
B1774_RS02580	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1774_RS02585	COG0735	belongs to the Fur family
B1774_RS02590	COG3443	Belongs to the bacterial solute-binding protein 9 family
B1774_RS02590	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1774_RS02595	COG1121	(ABC) transporter
B1774_RS02600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1774_RS02610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1774_RS02630	COG0589	response to stress
B1774_RS02635	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B1774_RS02640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1774_RS02645	COG0698	ribose 5-phosphate isomerase
B1774_RS02650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B1774_RS02655	COG0778	Nitroreductase
B1774_RS02660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1774_RS02670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1774_RS02675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1774_RS02680	COG1120	ATPase activity
B1774_RS02695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1774_RS02705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B1774_RS02710	COG0406	alpha-ribazole phosphatase activity
B1774_RS02715	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
B1774_RS02720	COG3118	belongs to the thioredoxin family
B1774_RS02730	COG2197	response regulator
B1774_RS02755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1774_RS02770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B1774_RS02785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1774_RS02790	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1774_RS02795	COG0740	serine-type endopeptidase activity
B1774_RS02800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1774_RS02800	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1774_RS02815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1774_RS02820	COG0006	proline dipeptidase activity
B1774_RS02825	COG4974	Belongs to the 'phage' integrase family
B1774_RS02830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1774_RS02835	COG0758	DNA mediated transformation
B1774_RS02835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1774_RS02850	COG0475	glutathione-regulated potassium exporter activity
B1774_RS02870	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1774_RS02875	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1774_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
B1774_RS02925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1774_RS02935	COG0436	Aminotransferase
B1774_RS02940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1774_RS02950	COG0149	triose-phosphate isomerase activity
B1774_RS02955	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
B1774_RS02960	COG0126	phosphoglycerate kinase activity
B1774_RS02965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1774_RS02985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B1774_RS02990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1774_RS02995	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1774_RS03000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1774_RS03005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1774_RS03030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B1774_RS03040	COG0242	peptide deformylase activity
B1774_RS03065	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1774_RS03080	COG1994	Peptidase M50
B1774_RS03080	COG0517	IMP dehydrogenase activity
B1774_RS03085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1774_RS03090	COG0492	ferredoxin-NADP+ reductase activity
B1774_RS03105	COG1994	Peptidase M50
B1774_RS03105	COG0517	IMP dehydrogenase activity
B1774_RS03110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1774_RS03115	COG0357	Ribosomal RNA small subunit methyltransferase G
B1774_RS03120	COG3854	ATPases associated with a variety of cellular activities
B1774_RS03125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1774_RS03130	COG0482	sulfurtransferase activity
B1774_RS03135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1774_RS03140	COG0792	nuclease activity
B1774_RS03145	COG0352	thiamine-phosphate diphosphorylase activity
B1774_RS03155	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1774_RS03160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1774_RS03170	COG0423	glycine-tRNA ligase activity
B1774_RS03175	COG0420	3'-5' exonuclease activity
B1774_RS03180	COG1187	pseudouridine synthase activity
B1774_RS03190	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B1774_RS03195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B1774_RS03205	COG1131	(ABC) transporter
B1774_RS03215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1774_RS03220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1774_RS03235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B1774_RS03240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1774_RS03245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1774_RS03285	COG1131	(ABC) transporter
B1774_RS03290	COG0842	Transport permease protein
B1774_RS03295	COG0396	ATPase activity
B1774_RS03300	COG0719	Fe-S assembly protein
B1774_RS03305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1774_RS03345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1774_RS03350	COG0473	3-isopropylmalate dehydrogenase activity
B1774_RS03355	COG0066	3-isopropylmalate dehydratase activity
B1774_RS03360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1774_RS03365	COG1285	pathogenesis
B1774_RS03370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1774_RS03375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1774_RS03385	COG0028	Belongs to the TPP enzyme family
B1774_RS03390	COG0129	dihydroxy-acid dehydratase activity
B1774_RS03395	COG0009	L-threonylcarbamoyladenylate synthase
B1774_RS03400	COG0519	Catalyzes the synthesis of GMP from XMP
B1774_RS03400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1774_RS03410	COG0151	Belongs to the GarS family
B1774_RS03415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1774_RS03420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1774_RS03425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1774_RS03430	COG0131	Imidazoleglycerol-phosphate dehydratase
B1774_RS03435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1774_RS03440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1774_RS03445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1774_RS03450	COG0124	histidyl-tRNA synthetase
B1774_RS03475	COG4152	abc transporter atp-binding protein
B1774_RS03480	COG1668	transmembrane transport
B1774_RS03505	COG0577	efflux transmembrane transporter activity
B1774_RS03505	COG1136	(ABC) transporter
B1774_RS03510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1774_RS03515	COG0481	GTPase activity
B1774_RS03520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1774_RS03520	COG2111	Na H antiporter
B1774_RS03525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1774_RS03530	COG3260	NADH ubiquinone oxidoreductase 20
B1774_RS03550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1774_RS03550	COG0493	'glutamate synthase
B1774_RS03565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1774_RS03570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1774_RS03575	COG1846	Transcriptional regulator
B1774_RS03600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1774_RS03665	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1774_RS03670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1774_RS03680	COG0649	NAD binding
B1774_RS03685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1774_RS03690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1774_RS03700	COG0713	ATP synthesis coupled electron transport
B1774_RS03705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1774_RS03710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1774_RS03720	COG0084	hydrolase, TatD family'
B1774_RS03725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1774_RS03730	COG1492	cobalamin metabolic process
B1774_RS03740	COG0411	ABC transporter
B1774_RS03750	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B1774_RS03780	COG0318	PFAM AMP-dependent synthetase and ligase
B1774_RS03805	COG0822	iron-sulfur transferase activity
B1774_RS03815	COG2217	Heavy metal translocating P-type atpase
B1774_RS03860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1774_RS03865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1774_RS03870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B1774_RS03870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B1774_RS03875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1774_RS03880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1774_RS03885	COG1111	helicase
B1774_RS03885	COG1205	dead DEAH box helicase
B1774_RS03895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1774_RS03900	COG1185	polyribonucleotide nucleotidyltransferase activity
B1774_RS03905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1774_RS03910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B1774_RS03915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1774_RS03930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1774_RS03935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1774_RS03940	COG0438	transferase activity, transferring glycosyl groups
B1774_RS03945	COG1260	myo-inositol-1-phosphate synthase
B1774_RS03950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1774_RS03955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1774_RS03960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1774_RS03970	COG0195	Participates in both transcription termination and antitermination
B1774_RS03975	COG0606	chelatase, subunit chli
B1774_RS03995	COG0222	ribosome binding
B1774_RS04000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1774_RS04005	COG0081	regulation of translation
B1774_RS04010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1774_RS04015	COG0250	Participates in transcription elongation, termination and antitermination
B1774_RS04020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1774_RS04025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1774_RS04030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1774_RS04055	COG0438	transferase activity, transferring glycosyl groups
B1774_RS04105	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B1774_RS04130	COG1476	TRANSCRIPTIONal
B1774_RS04175	COG0571	ribonuclease III activity
B1774_RS04180	COG1254	Belongs to the acylphosphatase family
B1774_RS04195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1774_RS04200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1774_RS04210	COG0318	PFAM AMP-dependent synthetase and ligase
B1774_RS04215	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B1774_RS04220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1774_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1774_RS04230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1774_RS04235	COG1847	R3H domain protein
B1774_RS04240	COG0706	membrane insertase activity
B1774_RS04250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1774_RS04255	COG0594	ribonuclease P activity
B1774_RS04260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1774_RS04265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1774_RS04270	COG0629	single-stranded DNA binding
B1774_RS04275	COG0360	Binds together with S18 to 16S ribosomal RNA
B1774_RS04295	COG0251	oxidation-reduction process
B1774_RS04310	COG0497	DNA recombination
B1774_RS04315	COG0697	spore germination
B1774_RS04325	COG0745	RESPONSE REGULATOR receiver
B1774_RS04330	COG2205	protein histidine kinase activity
B1774_RS04335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1774_RS04340	COG2197	response regulator
B1774_RS04350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1774_RS04380	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1774_RS04465	COG0740	serine-type endopeptidase activity
B1774_RS04470	COG4695	Portal protein
B1774_RS04550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1774_RS04550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1774_RS04600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B1774_RS04620	COG4974	Belongs to the 'phage' integrase family
B1774_RS04625	COG0732	type I restriction modification DNA specificity domain
B1774_RS04630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B1774_RS04645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1774_RS04650	COG0424	maF-like protein
B1774_RS04660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1774_RS04660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1774_RS04665	COG0174	glutamine synthetase
B1774_RS04675	COG0004	ammonium transporteR
B1774_RS04680	COG0745	RESPONSE REGULATOR receiver
B1774_RS04690	COG0069	glutamate synthase activity
B1774_RS04695	COG0107	imidazoleglycerol-phosphate synthase activity
B1774_RS04700	COG0067	glutamate synthase
B1774_RS04705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1774_RS04710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1774_RS04715	COG0493	'glutamate synthase
B1774_RS04715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1774_RS04720	COG1971	Probably functions as a manganese efflux pump
B1774_RS04725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1774_RS04735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B1774_RS04740	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B1774_RS04745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1774_RS04750	COG0726	polysaccharide deacetylase
B1774_RS04765	COG2197	response regulator
B1774_RS04770	COG0045	succinate-CoA ligase (ADP-forming) activity
B1774_RS04770	COG1042	CoA-binding domain protein
B1774_RS04770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1774_RS04795	COG0535	radical SAM domain protein
B1774_RS04795	COG1433	Dinitrogenase iron-molybdenum cofactor
B1774_RS04820	COG0347	Belongs to the P(II) protein family
B1774_RS04825	COG0347	Belongs to the P(II) protein family
B1774_RS04830	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B1774_RS04835	COG3842	ATPase activity
B1774_RS04840	COG4149	molybdate abc transporter
B1774_RS04845	COG0725	ABC transporter, periplasmic molybdate-binding protein
B1774_RS04850	COG0745	RESPONSE REGULATOR receiver
B1774_RS04880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1774_RS04885	COG1120	ATPase activity
B1774_RS04905	COG1132	(ABC) transporter
B1774_RS04930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1774_RS04935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1774_RS04935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1774_RS04945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1774_RS04945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1774_RS04960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1774_RS04970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B1774_RS04975	COG0210	DNA helicase
B1774_RS04980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1774_RS04985	COG0540	Belongs to the ATCase OTCase family
B1774_RS04990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1774_RS04995	COG0505	Belongs to the CarA family
B1774_RS05000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1774_RS05005	COG0543	2 iron, 2 sulfur cluster binding
B1774_RS05010	COG0302	gtp cyclohydrolase
B1774_RS05015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1774_RS05020	COG0460	homoserine dehydrogenase
B1774_RS05025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1774_RS05030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1774_RS05035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1774_RS05040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1774_RS05045	COG2890	protein-(glutamine-N5) methyltransferase activity
B1774_RS05050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1774_RS05065	COG4974	Belongs to the 'phage' integrase family
B1774_RS05070	COG0322	excinuclease ABC activity
B1774_RS05080	COG0561	phosphatase activity
B1774_RS05085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1774_RS05110	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B1774_RS05115	COG1980	fructose-bisphosphate aldolase activity
B1774_RS05120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1774_RS05125	COG0592	DNA-directed DNA polymerase activity
B1774_RS05150	COG5002	protein histidine kinase activity
B1774_RS05175	COG0788	formyltetrahydrofolate deformylase activity
B1774_RS05190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1774_RS05215	COG0640	Transcriptional regulator
B1774_RS05230	COG0431	NADPH-dependent FMN reductase
B1774_RS05250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B1774_RS05255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1774_RS05260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1774_RS05270	COG0137	argininosuccinate synthase activity
B1774_RS05275	COG0165	Argininosuccinate lyase
B1774_RS05280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1774_RS05290	COG1307	EDD domain protein, DegV family
B1774_RS05300	COG1307	EDD domain protein, DegV family
B1774_RS05305	COG1307	EDD domain protein, DegV family
B1774_RS05310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1774_RS05315	COG0018	arginyl-trna synthetase
B1774_RS05325	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B1774_RS05340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1774_RS05345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1774_RS05350	COG1028	Short-chain dehydrogenase reductase Sdr
B1774_RS05355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1774_RS05360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1774_RS05365	COG1032	radical SAM domain protein
B1774_RS05370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1774_RS05375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1774_RS05390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1774_RS05400	COG0789	Transcriptional regulator
B1774_RS05405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1774_RS05410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1774_RS05420	COG1058	Belongs to the CinA family
B1774_RS05420	COG1546	Belongs to the CinA family
B1774_RS05425	COG1872	DUF167
B1774_RS05435	COG0745	RESPONSE REGULATOR receiver
B1774_RS05450	COG1217	gtp-binding protein TYPA
B1774_RS05460	COG0589	response to stress
B1774_RS05465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B1774_RS05480	COG3422	double-strand break repair
B1774_RS05490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B1774_RS05505	COG3885	ferrous iron binding
B1774_RS05505	COG2078	PFAM AMMECR1 domain protein
B1774_RS05530	COG1666	GTP binding
B1774_RS05555	COG0237	dephospho-CoA kinase activity
B1774_RS05560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1774_RS05565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1774_RS05570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1774_RS05575	COG0254	rRNA binding
B1774_RS05580	COG3872	metal-dependent enzyme
B1774_RS05585	COG0140	phosphoribosyl-ATP diphosphatase activity
B1774_RS05585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1774_RS05595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1774_RS05610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1774_RS05615	COG0154	amidase activity
B1774_RS05630	COG1476	TRANSCRIPTIONal
B1774_RS05645	COG1522	sequence-specific DNA binding
B1774_RS05650	COG0436	Aminotransferase
B1774_RS05655	COG0180	Tryptophanyl-tRNA synthetase
B1774_RS05660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1774_RS05670	COG1105	Belongs to the carbohydrate kinase PfkB family
B1774_RS05680	COG1595	DNA-templated transcription, initiation
B1774_RS05690	COG2197	response regulator
B1774_RS05695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B1774_RS05700	COG1459	type II secretion system
B1774_RS05740	COG3769	mannosylglycerate metabolic process
B1774_RS05745	COG1714	RDD family
B1774_RS05750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1774_RS05770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1774_RS05780	COG0167	dihydroorotate dehydrogenase activity
B1774_RS05785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B1774_RS05790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1774_RS05795	COG0564	pseudouridine synthase activity
B1774_RS05820	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B1774_RS05820	COG2199	diguanylate cyclase activity
B1774_RS05830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1774_RS05835	COG1862	Preprotein translocase
B1774_RS05840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1774_RS05860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1774_RS05865	COG0671	phosphoesterase, PA-phosphatase related
B1774_RS05870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1774_RS05870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1774_RS05885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1774_RS05890	COG1160	GTP binding
B1774_RS05895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1774_RS05900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1774_RS05905	COG0484	heat shock protein binding
B1774_RS05910	COG0443	Heat shock 70 kDa protein
B1774_RS05915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1774_RS05920	COG1420	regulation of RNA biosynthetic process
B1774_RS05945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B1774_RS05950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1774_RS05955	COG0504	CTP synthase activity
B1774_RS05960	COG0484	heat shock protein binding
B1774_RS05965	COG0789	Transcriptional regulator
B1774_RS05970	COG0542	response to heat
B1774_RS05980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B1774_RS06005	COG2226	methyltransferase
B1774_RS06015	COG0406	alpha-ribazole phosphatase activity
B1774_RS06030	COG1253	flavin adenine dinucleotide binding
B1774_RS06035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1774_RS06040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1774_RS06045	COG0459	protein refolding
B1774_RS06050	COG0612	Peptidase, M16
B1774_RS06055	COG0375	protein maturation
B1774_RS06065	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B1774_RS06070	COG0298	carbon dioxide binding
B1774_RS06080	COG0309	Hydrogenase expression formation protein (HypE)
B1774_RS06085	COG1309	transcriptional regulator
B1774_RS06125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1774_RS06135	COG2095	MarC family integral membrane protein
B1774_RS06155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1774_RS06175	COG1040	competence protein
B1774_RS06180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B1774_RS06185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1774_RS06195	COG2003	Belongs to the UPF0758 family
B1774_RS06245	COG0512	Glutamine amidotransferase of anthranilate synthase
B1774_RS06250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1774_RS06260	COG0135	phosphoribosylanthranilate isomerase activity
B1774_RS06265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B1774_RS06270	COG0133	tryptophan synthase activity
B1774_RS06280	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B1774_RS06285	COG0357	Ribosomal RNA small subunit methyltransferase G
B1774_RS06295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1774_RS06300	COG1993	acr, cog1993
B1774_RS06315	COG2814	Major facilitator Superfamily
B1774_RS06320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B1774_RS06335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1774_RS06360	COG0789	Transcriptional regulator
B1774_RS06365	COG1132	(ABC) transporter
B1774_RS06370	COG1032	radical SAM domain protein
B1774_RS06375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1774_RS06380	COG0477	Major facilitator Superfamily
B1774_RS06415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1774_RS06460	COG3260	NADH ubiquinone oxidoreductase 20
B1774_RS06465	COG3261	NADH dehydrogenase
B1774_RS06465	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
B1774_RS06470	COG0651	ATP synthesis coupled electron transport
B1774_RS06480	COG0650	Formate hydrogenlyase subunit 4
B1774_RS06485	COG0651	ATP synthesis coupled electron transport
B1774_RS06490	COG1803	Methylglyoxal synthase
B1774_RS06500	COG0668	transmembrane transport
B1774_RS06510	COG0450	alkyl hydroperoxide reductase
B1774_RS06535	COG1704	LemA family
B1774_RS06540	COG0501	Belongs to the peptidase M48B family
B1774_RS06545	COG1045	serine acetyltransferase
B1774_RS06550	COG1324	tolerance protein
B1774_RS06555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1774_RS06560	COG2226	methyltransferase
B1774_RS06570	COG1959	2 iron, 2 sulfur cluster binding
B1774_RS06590	COG0805	protein transport
B1774_RS06595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1774_RS06600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1774_RS06605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1774_RS06610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1774_RS06615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1774_RS06625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1774_RS06630	COG2137	regulation of response to DNA damage stimulus
B1774_RS06635	COG1418	mRNA catabolic process
B1774_RS06635	COG4372	Transposase
B1774_RS06640	COG1692	metallophosphoesterase
B1774_RS06645	COG0613	PHP domain protein
B1774_RS06650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1774_RS06660	COG1720	tRNA m6t6A37 methyltransferase activity
B1774_RS06680	COG0393	Putative heavy-metal-binding
B1774_RS06690	COG1131	(ABC) transporter
B1774_RS06695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B1774_RS06725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1774_RS06730	COG4651	solute:proton antiporter activity
B1774_RS06730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1774_RS06735	COG1234	tRNA 3'-trailer cleavage
B1774_RS06745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1774_RS06755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B1774_RS06770	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
B1774_RS06780	COG3956	TIGRFAM MazG family protein
B1774_RS06785	COG2738	Putative neutral zinc metallopeptidase
B1774_RS06790	COG0268	Binds directly to 16S ribosomal RNA
B1774_RS06795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1774_RS06805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus