locus-tag	class	description
DHCVS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DHCVS_RS00010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DHCVS_RS00015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DHCVS_RS00020	COG0187	DNA topoisomerase II activity
DHCVS_RS00025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DHCVS_RS00030	COG0124	histidyl-tRNA synthetase
DHCVS_RS00040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DHCVS_RS00045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DHCVS_RS00050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DHCVS_RS00090	COG1490	D-aminoacyl-tRNA deacylase activity
DHCVS_RS00125	COG0569	domain protein
DHCVS_RS00135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DHCVS_RS00140	COG0569	domain protein
DHCVS_RS00150	COG0306	phosphate transporter
DHCVS_RS00165	COG0543	2 iron, 2 sulfur cluster binding
DHCVS_RS00170	COG0493	'glutamate synthase
DHCVS_RS00185	COG2226	methyltransferase
DHCVS_RS00205	COG0012	GTP binding
DHCVS_RS00230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DHCVS_RS00235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DHCVS_RS00240	COG0343	queuine tRNA-ribosyltransferase activity
DHCVS_RS00245	COG1979	alcohol dehydrogenase
DHCVS_RS00260	COG0542	response to heat
DHCVS_RS00270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DHCVS_RS00275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DHCVS_RS00280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DHCVS_RS00295	COG4974	Belongs to the 'phage' integrase family
DHCVS_RS00300	COG2963	transposase activity
DHCVS_RS00305	COG2801	Transposase and inactivated derivatives
DHCVS_RS00320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DHCVS_RS00400	COG2205	protein histidine kinase activity
DHCVS_RS00405	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS00425	COG2963	transposase activity
DHCVS_RS00430	COG2801	Transposase and inactivated derivatives
DHCVS_RS00440	COG4585	Histidine kinase
DHCVS_RS00445	COG2205	protein histidine kinase activity
DHCVS_RS00450	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS00485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DHCVS_RS00505	COG2205	protein histidine kinase activity
DHCVS_RS00505	COG3292	Two component regulator propeller
DHCVS_RS00505	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS00525	COG0746	molybdenum cofactor guanylyltransferase activity
DHCVS_RS00560	COG1307	EDD domain protein, DegV family
DHCVS_RS00565	COG1704	LemA family
DHCVS_RS00575	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DHCVS_RS00590	COG0437	4 iron, 4 sulfur cluster binding
DHCVS_RS00615	COG0693	protein deglycase activity
DHCVS_RS00620	COG0511	ligase activity, forming carbon-carbon bonds
DHCVS_RS00620	COG5016	pyruvate
DHCVS_RS00625	COG0439	Biotin carboxylase
DHCVS_RS00635	COG0493	'glutamate synthase
DHCVS_RS00640	COG1063	alcohol dehydrogenase
DHCVS_RS00645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DHCVS_RS00660	COG0432	Pfam Uncharacterised protein family UPF0047
DHCVS_RS00665	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS00690	COG4968	Prepilin-type N-terminal cleavage methylation domain
DHCVS_RS00695	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS00700	COG5002	protein histidine kinase activity
DHCVS_RS00705	COG1803	Methylglyoxal synthase
DHCVS_RS00710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DHCVS_RS00715	COG0573	inorganic phosphate transmembrane transporter activity
DHCVS_RS00720	COG0581	inorganic phosphate transmembrane transporter activity
DHCVS_RS00725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DHCVS_RS00730	COG0704	Plays a role in the regulation of phosphate uptake
DHCVS_RS00765	COG2267	carboxylic ester hydrolase activity
DHCVS_RS00810	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS00835	COG0513	Belongs to the DEAD box helicase family
DHCVS_RS00850	COG5557	Pfam Polysulphide reductase, NrfD
DHCVS_RS00860	COG0742	ribosomal rna small subunit methyltransferase
DHCVS_RS00870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DHCVS_RS00880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DHCVS_RS00885	COG0495	leucyl-tRNA aminoacylation
DHCVS_RS00890	COG2081	HI0933 family
DHCVS_RS00895	COG0456	acetyltransferase
DHCVS_RS00895	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DHCVS_RS00910	COG1592	Rubrerythrin
DHCVS_RS00910	COG1773	rubredoxin
DHCVS_RS00925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DHCVS_RS00935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DHCVS_RS00940	COG0363	glucosamine-6-phosphate deaminase activity
DHCVS_RS00945	COG0667	Aldo Keto reductase
DHCVS_RS00950	COG1342	Belongs to the UPF0251 family
DHCVS_RS00975	COG0488	(ABC) transporter
DHCVS_RS00985	COG2081	HI0933 family
DHCVS_RS01045	COG0484	heat shock protein binding
DHCVS_RS01135	COG1404	Belongs to the peptidase S8 family
DHCVS_RS01165	COG4974	Belongs to the 'phage' integrase family
DHCVS_RS01210	COG0592	DNA-directed DNA polymerase activity
DHCVS_RS01255	COG0210	DNA helicase
DHCVS_RS01310	COG1752	Esterase of the alpha-beta hydrolase superfamily
DHCVS_RS01340	COG0123	including yeast histone deacetylase and acetoin utilization protein
DHCVS_RS01350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DHCVS_RS01355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DHCVS_RS01360	COG0617	tRNA 3'-terminal CCA addition
DHCVS_RS01370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DHCVS_RS01380	COG0336	Belongs to the RNA methyltransferase TrmD family
DHCVS_RS01385	COG2001	Belongs to the MraZ family
DHCVS_RS01390	COG0275	rRNA processing
DHCVS_RS01400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DHCVS_RS01405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DHCVS_RS01420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DHCVS_RS01425	COG1610	YqeY-like protein
DHCVS_RS01510	COG3409	Peptidoglycan-binding domain 1 protein
DHCVS_RS01510	COG0793	Belongs to the peptidase S41A family
DHCVS_RS01515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DHCVS_RS01520	COG0072	phenylalanine-tRNA ligase activity
DHCVS_RS01520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DHCVS_RS01525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DHCVS_RS01530	COG0442	prolyl-tRNA aminoacylation
DHCVS_RS01545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DHCVS_RS01550	COG4589	Belongs to the CDS family
DHCVS_RS01555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DHCVS_RS01560	COG0233	cytoplasmic translational termination
DHCVS_RS01565	COG0528	UMP kinase activity
DHCVS_RS01570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DHCVS_RS01575	COG0052	Belongs to the universal ribosomal protein uS2 family
DHCVS_RS01580	COG0047	phosphoribosylformylglycinamidine synthase activity
DHCVS_RS01585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DHCVS_RS01610	COG0516	GMP reductase activity
DHCVS_RS01615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DHCVS_RS01625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DHCVS_RS01630	COG0142	geranyltranstransferase activity
DHCVS_RS01635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DHCVS_RS01645	COG0799	negative regulation of ribosome biogenesis
DHCVS_RS01650	COG0105	UTP biosynthetic process
DHCVS_RS01655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DHCVS_RS01660	COG0802	atpase or kinase
DHCVS_RS01665	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DHCVS_RS01675	COG2226	methyltransferase
DHCVS_RS01680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DHCVS_RS01700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DHCVS_RS01705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DHCVS_RS01720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DHCVS_RS01725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DHCVS_RS01725	COG3620	sequence-specific DNA binding
DHCVS_RS01725	COG0617	tRNA 3'-terminal CCA addition
DHCVS_RS01730	COG1131	(ABC) transporter
DHCVS_RS01735	COG0842	Transport permease protein
DHCVS_RS01750	COG1597	lipid kinase activity
DHCVS_RS01765	COG1126	abc transporter atp-binding protein
DHCVS_RS01770	COG0765	amino acid transport
DHCVS_RS01790	COG0598	Magnesium transport protein CorA
DHCVS_RS01810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DHCVS_RS01810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DHCVS_RS01820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DHCVS_RS01825	COG0525	valine-tRNA ligase activity
DHCVS_RS01845	COG0653	protein targeting
DHCVS_RS01850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DHCVS_RS01860	COG1573	uracil-dna glycosylase
DHCVS_RS01865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DHCVS_RS01870	COG1674	ftsk spoiiie
DHCVS_RS01875	COG0556	nucleotide-excision repair
DHCVS_RS01880	COG0632	four-way junction helicase activity
DHCVS_RS01885	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DHCVS_RS01890	COG0217	transcriptional regulatory protein
DHCVS_RS01895	COG0736	holo-[acyl-carrier-protein] synthase activity
DHCVS_RS01900	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DHCVS_RS01905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DHCVS_RS01915	COG0066	3-isopropylmalate dehydratase activity
DHCVS_RS01920	COG0538	isocitrate dehydrogenase activity
DHCVS_RS01925	COG0039	L-malate dehydrogenase activity
DHCVS_RS01935	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DHCVS_RS01945	COG0537	adenosine 5'-monophosphoramidase activity
DHCVS_RS01955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DHCVS_RS01960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DHCVS_RS01970	COG0287	Prephenate dehydrogenase
DHCVS_RS01970	COG1605	Chorismate mutase
DHCVS_RS01975	COG1605	Chorismate mutase
DHCVS_RS01975	COG0077	Prephenate dehydratase
DHCVS_RS01980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DHCVS_RS02000	COG0710	3-dehydroquinate dehydratase activity
DHCVS_RS02005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DHCVS_RS02010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DHCVS_RS02015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DHCVS_RS02025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DHCVS_RS02030	COG0051	transcription antitermination factor activity, RNA binding
DHCVS_RS02035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DHCVS_RS02060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DHCVS_RS02065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DHCVS_RS02085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DHCVS_RS02095	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DHCVS_RS02105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DHCVS_RS02115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DHCVS_RS02125	COG0200	Binds to the 23S rRNA
DHCVS_RS02135	COG0563	adenylate kinase activity
DHCVS_RS02140	COG0024	Methionine aminopeptidase
DHCVS_RS02155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DHCVS_RS02165	COG0202	RNA polymerase activity
DHCVS_RS02170	COG0203	ribosomal protein L17
DHCVS_RS02180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DHCVS_RS02200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DHCVS_RS02210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DHCVS_RS02215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DHCVS_RS02235	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DHCVS_RS02240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DHCVS_RS02250	COG1131	(ABC) transporter
DHCVS_RS02255	COG2030	dehydratase
DHCVS_RS02280	COG0312	modulator of DNA gyrase
DHCVS_RS02285	COG0312	modulator of DNA gyrase
DHCVS_RS02290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DHCVS_RS02300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DHCVS_RS02305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DHCVS_RS02310	COG1881	PFAM PEBP family protein
DHCVS_RS02315	COG1011	Hydrolase
DHCVS_RS02320	COG0019	diaminopimelate decarboxylase activity
DHCVS_RS02325	COG0470	DNA polymerase III
DHCVS_RS02330	COG1774	PSP1 C-terminal conserved region
DHCVS_RS02350	COG0305	Participates in initiation and elongation during chromosome replication
DHCVS_RS02355	COG0359	binds to the 23S rRNA
DHCVS_RS02360	COG0492	ferredoxin-NADP+ reductase activity
DHCVS_RS02365	COG0416	fatty acid biosynthetic process
DHCVS_RS02370	COG1924	4 iron, 4 sulfur cluster binding
DHCVS_RS02375	COG1473	amidohydrolase
DHCVS_RS02380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DHCVS_RS02395	COG0419	ATPase involved in DNA repair
DHCVS_RS02400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DHCVS_RS02405	COG0358	DNA primase activity
DHCVS_RS02410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DHCVS_RS02415	COG0574	Belongs to the PEP-utilizing enzyme family
DHCVS_RS02415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DHCVS_RS02430	COG0356	it plays a direct role in the translocation of protons across the membrane
DHCVS_RS02440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DHCVS_RS02445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DHCVS_RS02450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DHCVS_RS02455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DHCVS_RS02460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DHCVS_RS02465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DHCVS_RS02470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DHCVS_RS02480	COG0228	four-way junction DNA binding
DHCVS_RS02490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DHCVS_RS02500	COG2003	Belongs to the UPF0758 family
DHCVS_RS02505	COG0747	negative chemotaxis
DHCVS_RS02535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DHCVS_RS02550	COG0598	Magnesium transport protein CorA
DHCVS_RS02555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DHCVS_RS02560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DHCVS_RS02565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DHCVS_RS02595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DHCVS_RS02605	COG0148	phosphopyruvate hydratase activity
DHCVS_RS02615	COG0193	aminoacyl-tRNA hydrolase activity
DHCVS_RS02620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DHCVS_RS02630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DHCVS_RS02635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DHCVS_RS02645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DHCVS_RS02660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DHCVS_RS02670	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DHCVS_RS02675	COG0456	acetyltransferase
DHCVS_RS02690	COG2226	methyltransferase
DHCVS_RS02700	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
DHCVS_RS02705	COG3259	Nickel-dependent hydrogenase
DHCVS_RS02725	COG0785	Cytochrome C biogenesis protein
DHCVS_RS02755	COG5002	protein histidine kinase activity
DHCVS_RS02770	COG1509	lysine 2,3-aminomutase activity
DHCVS_RS02775	COG1181	Belongs to the D-alanine--D-alanine ligase family
DHCVS_RS02780	COG0735	belongs to the Fur family
DHCVS_RS02785	COG3443	Belongs to the bacterial solute-binding protein 9 family
DHCVS_RS02785	COG0803	Belongs to the bacterial solute-binding protein 9 family
DHCVS_RS02790	COG1121	(ABC) transporter
DHCVS_RS02795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DHCVS_RS02805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DHCVS_RS02825	COG0589	response to stress
DHCVS_RS02830	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DHCVS_RS02835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DHCVS_RS02840	COG0698	ribose 5-phosphate isomerase
DHCVS_RS02845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DHCVS_RS02855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DHCVS_RS02865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DHCVS_RS02870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DHCVS_RS02875	COG1120	ATPase activity
DHCVS_RS02890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DHCVS_RS02900	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DHCVS_RS02905	COG0406	alpha-ribazole phosphatase activity
DHCVS_RS02910	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
DHCVS_RS02915	COG3118	belongs to the thioredoxin family
DHCVS_RS02925	COG2197	response regulator
DHCVS_RS02950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DHCVS_RS02955	COG0489	protein tyrosine kinase activity
DHCVS_RS02965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DHCVS_RS02980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DHCVS_RS02985	COG0544	peptidyl-prolyl cis-trans isomerase activity
DHCVS_RS02990	COG0740	serine-type endopeptidase activity
DHCVS_RS03010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DHCVS_RS03015	COG0006	proline dipeptidase activity
DHCVS_RS03020	COG4974	Belongs to the 'phage' integrase family
DHCVS_RS03025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DHCVS_RS03030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DHCVS_RS03030	COG0758	DNA mediated transformation
DHCVS_RS03045	COG0475	glutathione-regulated potassium exporter activity
DHCVS_RS03065	COG0674	pyruvate-flavodoxin oxidoreductase activity
DHCVS_RS03070	COG1013	pyruvate-flavodoxin oxidoreductase activity
DHCVS_RS03085	COG1034	ATP synthesis coupled electron transport
DHCVS_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
DHCVS_RS03120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DHCVS_RS03130	COG0436	Aminotransferase
DHCVS_RS03135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DHCVS_RS03140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DHCVS_RS03150	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DHCVS_RS03155	COG0126	phosphoglycerate kinase activity
DHCVS_RS03160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DHCVS_RS03175	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DHCVS_RS03185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DHCVS_RS03190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DHCVS_RS03220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DHCVS_RS03255	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DHCVS_RS03270	COG0517	IMP dehydrogenase activity
DHCVS_RS03270	COG1994	Peptidase M50
DHCVS_RS03275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DHCVS_RS03280	COG0492	ferredoxin-NADP+ reductase activity
DHCVS_RS03295	COG0517	IMP dehydrogenase activity
DHCVS_RS03295	COG1994	Peptidase M50
DHCVS_RS03300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DHCVS_RS03310	COG3854	ATPases associated with a variety of cellular activities
DHCVS_RS03315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DHCVS_RS03320	COG0482	sulfurtransferase activity
DHCVS_RS03325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DHCVS_RS03330	COG0792	nuclease activity
DHCVS_RS03335	COG0352	thiamine-phosphate diphosphorylase activity
DHCVS_RS03345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DHCVS_RS03350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DHCVS_RS03360	COG0423	glycine-tRNA ligase activity
DHCVS_RS03365	COG0420	3'-5' exonuclease activity
DHCVS_RS03370	COG1187	pseudouridine synthase activity
DHCVS_RS03380	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DHCVS_RS03385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DHCVS_RS03425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DHCVS_RS03430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DHCVS_RS03445	COG1695	Transcriptional regulator
DHCVS_RS03470	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DHCVS_RS03470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DHCVS_RS03480	COG1131	(ABC) transporter
DHCVS_RS03485	COG0842	Transport permease protein
DHCVS_RS03490	COG0396	ATPase activity
DHCVS_RS03495	COG0719	Fe-S assembly protein
DHCVS_RS03540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DHCVS_RS03545	COG0473	3-isopropylmalate dehydrogenase activity
DHCVS_RS03550	COG0066	3-isopropylmalate dehydratase activity
DHCVS_RS03555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DHCVS_RS03560	COG1285	pathogenesis
DHCVS_RS03565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DHCVS_RS03580	COG0028	Belongs to the TPP enzyme family
DHCVS_RS03590	COG0009	L-threonylcarbamoyladenylate synthase
DHCVS_RS03605	COG0151	Belongs to the GarS family
DHCVS_RS03610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DHCVS_RS03615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DHCVS_RS03620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DHCVS_RS03625	COG0131	Imidazoleglycerol-phosphate dehydratase
DHCVS_RS03630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DHCVS_RS03635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DHCVS_RS03640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DHCVS_RS03645	COG0124	histidyl-tRNA synthetase
DHCVS_RS03670	COG4152	abc transporter atp-binding protein
DHCVS_RS03705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DHCVS_RS03715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DHCVS_RS03715	COG2111	Na H antiporter
DHCVS_RS03720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DHCVS_RS03725	COG3260	NADH ubiquinone oxidoreductase 20
DHCVS_RS03745	COG0493	'glutamate synthase
DHCVS_RS03745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DHCVS_RS03760	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DHCVS_RS03765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DHCVS_RS03770	COG1846	Transcriptional regulator
DHCVS_RS03775	COG2409	Drug exporters of the RND superfamily
DHCVS_RS03775	COG1033	growth of symbiont in host cell
DHCVS_RS03780	COG2801	Transposase and inactivated derivatives
DHCVS_RS03785	COG2963	transposase activity
DHCVS_RS03870	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DHCVS_RS03880	COG0649	NAD binding
DHCVS_RS03885	COG0649	NAD binding
DHCVS_RS03890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DHCVS_RS03895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DHCVS_RS03905	COG0713	ATP synthesis coupled electron transport
DHCVS_RS03910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DHCVS_RS03915	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DHCVS_RS03925	COG0084	hydrolase, TatD family'
DHCVS_RS03930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DHCVS_RS03945	COG0411	ABC transporter
DHCVS_RS03955	COG0318	PFAM AMP-dependent synthetase and ligase
DHCVS_RS03985	COG0318	PFAM AMP-dependent synthetase and ligase
DHCVS_RS04005	COG0822	iron-sulfur transferase activity
DHCVS_RS04015	COG2217	Heavy metal translocating P-type atpase
DHCVS_RS04055	COG0107	imidazoleglycerol-phosphate synthase activity
DHCVS_RS04065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DHCVS_RS04070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DHCVS_RS04075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DHCVS_RS04075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DHCVS_RS04080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DHCVS_RS04090	COG1205	dead DEAH box helicase
DHCVS_RS04090	COG1111	helicase
DHCVS_RS04100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DHCVS_RS04105	COG1185	polyribonucleotide nucleotidyltransferase activity
DHCVS_RS04110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DHCVS_RS04115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DHCVS_RS04120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DHCVS_RS04140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DHCVS_RS04145	COG0438	transferase activity, transferring glycosyl groups
DHCVS_RS04150	COG1260	myo-inositol-1-phosphate synthase
DHCVS_RS04160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DHCVS_RS04165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DHCVS_RS04175	COG0195	Participates in both transcription termination and antitermination
DHCVS_RS04180	COG0606	chelatase, subunit chli
DHCVS_RS04200	COG0222	ribosome binding
DHCVS_RS04205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DHCVS_RS04210	COG0081	regulation of translation
DHCVS_RS04220	COG0250	Participates in transcription elongation, termination and antitermination
DHCVS_RS04225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DHCVS_RS04265	COG0640	Transcriptional regulator
DHCVS_RS04270	COG0701	Predicted permease
DHCVS_RS04285	COG2211	Major facilitator Superfamily
DHCVS_RS04290	COG0348	domain, Protein
DHCVS_RS04290	COG3901	Regulator of nitric oxide reductase transcription
DHCVS_RS04315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DHCVS_RS04370	COG1254	Belongs to the acylphosphatase family
DHCVS_RS04380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DHCVS_RS04390	COG1307	EDD domain protein, DegV family
DHCVS_RS04395	COG0318	PFAM AMP-dependent synthetase and ligase
DHCVS_RS04400	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DHCVS_RS04405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DHCVS_RS04410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DHCVS_RS04415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DHCVS_RS04420	COG1847	R3H domain protein
DHCVS_RS04425	COG0706	membrane insertase activity
DHCVS_RS04440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DHCVS_RS04445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DHCVS_RS04450	COG0629	single-stranded DNA binding
DHCVS_RS04455	COG0360	Binds together with S18 to 16S ribosomal RNA
DHCVS_RS04470	COG0251	oxidation-reduction process
DHCVS_RS04485	COG0497	DNA recombination
DHCVS_RS04490	COG0697	spore germination
DHCVS_RS04500	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS04505	COG2205	protein histidine kinase activity
DHCVS_RS04510	COG4608	Belongs to the ABC transporter superfamily
DHCVS_RS04515	COG0444	Belongs to the ABC transporter superfamily
DHCVS_RS04520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DHCVS_RS04525	COG0601	transmembrane transport
DHCVS_RS04530	COG4166	transmembrane transport
DHCVS_RS04535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DHCVS_RS04540	COG2197	response regulator
DHCVS_RS04550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DHCVS_RS04570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DHCVS_RS04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DHCVS_RS04575	COG0174	glutamine synthetase
DHCVS_RS04585	COG0004	ammonium transporteR
DHCVS_RS04590	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS04600	COG0069	glutamate synthase activity
DHCVS_RS04605	COG0107	imidazoleglycerol-phosphate synthase activity
DHCVS_RS04610	COG0067	glutamate synthase
DHCVS_RS04615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DHCVS_RS04625	COG0493	'glutamate synthase
DHCVS_RS04625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DHCVS_RS04635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DHCVS_RS04655	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DHCVS_RS04660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DHCVS_RS04665	COG0726	polysaccharide deacetylase
DHCVS_RS04690	COG1132	(ABC) transporter
DHCVS_RS04720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DHCVS_RS04725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DHCVS_RS04725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DHCVS_RS04735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DHCVS_RS04735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DHCVS_RS04750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DHCVS_RS04760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DHCVS_RS04765	COG0210	DNA helicase
DHCVS_RS04770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DHCVS_RS04775	COG0540	Belongs to the ATCase OTCase family
DHCVS_RS04780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DHCVS_RS04785	COG0505	Belongs to the CarA family
DHCVS_RS04790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DHCVS_RS04795	COG0543	2 iron, 2 sulfur cluster binding
DHCVS_RS04800	COG0302	gtp cyclohydrolase
DHCVS_RS04805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DHCVS_RS04810	COG0460	homoserine dehydrogenase
DHCVS_RS04815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DHCVS_RS04820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DHCVS_RS04825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DHCVS_RS04830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DHCVS_RS04835	COG2890	protein-(glutamine-N5) methyltransferase activity
DHCVS_RS04840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DHCVS_RS04855	COG4974	Belongs to the 'phage' integrase family
DHCVS_RS04860	COG0322	excinuclease ABC activity
DHCVS_RS04870	COG0561	phosphatase activity
DHCVS_RS04875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DHCVS_RS04895	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DHCVS_RS04900	COG1980	fructose-bisphosphate aldolase activity
DHCVS_RS04905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DHCVS_RS04910	COG0592	DNA-directed DNA polymerase activity
DHCVS_RS04920	COG5002	protein histidine kinase activity
DHCVS_RS04970	COG0788	formyltetrahydrofolate deformylase activity
DHCVS_RS04985	COG0798	PFAM Bile acid sodium symporter
DHCVS_RS04990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DHCVS_RS04995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DHCVS_RS05015	COG0640	Transcriptional regulator
DHCVS_RS05030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DHCVS_RS05050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DHCVS_RS05060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DHCVS_RS05070	COG0137	argininosuccinate synthase activity
DHCVS_RS05075	COG0165	Argininosuccinate lyase
DHCVS_RS05080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DHCVS_RS05090	COG1307	EDD domain protein, DegV family
DHCVS_RS05100	COG1307	EDD domain protein, DegV family
DHCVS_RS05105	COG1307	EDD domain protein, DegV family
DHCVS_RS05110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DHCVS_RS05120	COG0018	arginyl-trna synthetase
DHCVS_RS05130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DHCVS_RS05150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DHCVS_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
DHCVS_RS05170	COG1032	radical SAM domain protein
DHCVS_RS05175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DHCVS_RS05180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DHCVS_RS05195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DHCVS_RS05200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DHCVS_RS05205	COG0789	Transcriptional regulator
DHCVS_RS05210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DHCVS_RS05215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DHCVS_RS05225	COG1546	Belongs to the CinA family
DHCVS_RS05225	COG1058	Belongs to the CinA family
DHCVS_RS05260	COG1217	gtp-binding protein TYPA
DHCVS_RS05280	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DHCVS_RS05300	COG3422	double-strand break repair
DHCVS_RS05305	COG0596	Alpha beta hydrolase
DHCVS_RS05310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DHCVS_RS05325	COG2078	PFAM AMMECR1 domain protein
DHCVS_RS05325	COG3885	ferrous iron binding
DHCVS_RS05365	COG0655	NAD(P)H dehydrogenase (quinone) activity
DHCVS_RS05385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DHCVS_RS05390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DHCVS_RS05400	COG0254	rRNA binding
DHCVS_RS05405	COG3872	metal-dependent enzyme
DHCVS_RS05410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DHCVS_RS05410	COG0140	phosphoribosyl-ATP diphosphatase activity
DHCVS_RS05420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DHCVS_RS05430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DHCVS_RS05435	COG0154	amidase activity
DHCVS_RS05465	COG1522	sequence-specific DNA binding
DHCVS_RS05470	COG0436	Aminotransferase
DHCVS_RS05475	COG0180	Tryptophanyl-tRNA synthetase
DHCVS_RS05480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DHCVS_RS05490	COG1105	Belongs to the carbohydrate kinase PfkB family
DHCVS_RS05500	COG1595	DNA-templated transcription, initiation
DHCVS_RS05510	COG2197	response regulator
DHCVS_RS05515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DHCVS_RS05520	COG1459	type II secretion system
DHCVS_RS05550	COG0107	imidazoleglycerol-phosphate synthase activity
DHCVS_RS05570	COG3769	mannosylglycerate metabolic process
DHCVS_RS05615	COG0167	dihydroorotate dehydrogenase activity
DHCVS_RS05620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DHCVS_RS05625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DHCVS_RS05630	COG0564	pseudouridine synthase activity
DHCVS_RS05655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DHCVS_RS05655	COG2199	diguanylate cyclase activity
DHCVS_RS05665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DHCVS_RS05670	COG1862	Preprotein translocase
DHCVS_RS05675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DHCVS_RS05695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DHCVS_RS05705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DHCVS_RS05705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DHCVS_RS05710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DHCVS_RS05725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DHCVS_RS05730	COG1160	GTP binding
DHCVS_RS05740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DHCVS_RS05745	COG0484	heat shock protein binding
DHCVS_RS05755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DHCVS_RS05760	COG1420	regulation of RNA biosynthetic process
DHCVS_RS05785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DHCVS_RS05790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DHCVS_RS05795	COG0504	CTP synthase activity
DHCVS_RS05800	COG0484	heat shock protein binding
DHCVS_RS05805	COG0789	Transcriptional regulator
DHCVS_RS05810	COG0542	response to heat
DHCVS_RS05820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DHCVS_RS05830	COG2226	methyltransferase
DHCVS_RS05850	COG2226	methyltransferase
DHCVS_RS05860	COG0406	alpha-ribazole phosphatase activity
DHCVS_RS05875	COG1253	flavin adenine dinucleotide binding
DHCVS_RS05880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DHCVS_RS05885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DHCVS_RS05890	COG0459	protein refolding
DHCVS_RS05895	COG0612	Peptidase, M16
DHCVS_RS05900	COG0375	protein maturation
DHCVS_RS05910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DHCVS_RS05915	COG0298	carbon dioxide binding
DHCVS_RS05925	COG0309	Hydrogenase expression formation protein (HypE)
DHCVS_RS05930	COG1309	transcriptional regulator
DHCVS_RS05985	COG2095	MarC family integral membrane protein
DHCVS_RS06005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DHCVS_RS06025	COG1040	competence protein
DHCVS_RS06030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DHCVS_RS06035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DHCVS_RS06045	COG2003	Belongs to the UPF0758 family
DHCVS_RS06100	COG0512	Glutamine amidotransferase of anthranilate synthase
DHCVS_RS06105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DHCVS_RS06115	COG0135	phosphoribosylanthranilate isomerase activity
DHCVS_RS06120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DHCVS_RS06125	COG0133	tryptophan synthase activity
DHCVS_RS06160	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DHCVS_RS06165	COG4608	Belongs to the ABC transporter superfamily
DHCVS_RS06170	COG0444	Belongs to the ABC transporter superfamily
DHCVS_RS06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DHCVS_RS06180	COG0601	transmembrane transport
DHCVS_RS06185	COG0747	negative chemotaxis
DHCVS_RS06215	COG2814	Major facilitator Superfamily
DHCVS_RS06220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DHCVS_RS06230	COG0735	belongs to the Fur family
DHCVS_RS06235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DHCVS_RS06280	COG1773	rubredoxin
DHCVS_RS06390	COG2963	transposase activity
DHCVS_RS06395	COG2801	Transposase and inactivated derivatives
DHCVS_RS06450	COG2205	protein histidine kinase activity
DHCVS_RS06455	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS06500	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS06500	COG2205	protein histidine kinase activity
DHCVS_RS06500	COG3292	Two component regulator propeller
DHCVS_RS06505	COG2963	transposase activity
DHCVS_RS06510	COG2801	Transposase and inactivated derivatives
DHCVS_RS06535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DHCVS_RS06605	COG2205	protein histidine kinase activity
DHCVS_RS06610	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS06680	COG0174	glutamine synthetase
DHCVS_RS06695	COG4585	Histidine kinase
DHCVS_RS06700	COG2197	response regulator
DHCVS_RS06730	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS06800	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS06880	COG1584	GPR1 FUN34 yaaH family protein
DHCVS_RS06900	COG0789	Transcriptional regulator
DHCVS_RS06905	COG1132	(ABC) transporter
DHCVS_RS06910	COG1032	radical SAM domain protein
DHCVS_RS06915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DHCVS_RS06920	COG1846	Transcriptional regulator
DHCVS_RS06945	COG0477	Major facilitator Superfamily
DHCVS_RS06965	COG1846	Transcriptional regulator
DHCVS_RS06980	COG2205	protein histidine kinase activity
DHCVS_RS06985	COG0745	RESPONSE REGULATOR receiver
DHCVS_RS07030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DHCVS_RS07075	COG3260	NADH ubiquinone oxidoreductase 20
DHCVS_RS07080	COG3261	NADH dehydrogenase
DHCVS_RS07080	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DHCVS_RS07085	COG0651	ATP synthesis coupled electron transport
DHCVS_RS07095	COG0650	Formate hydrogenlyase subunit 4
DHCVS_RS07100	COG0651	ATP synthesis coupled electron transport
DHCVS_RS07105	COG1803	Methylglyoxal synthase
DHCVS_RS07115	COG0668	transmembrane transport
DHCVS_RS07125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DHCVS_RS07140	COG0450	alkyl hydroperoxide reductase
DHCVS_RS07155	COG0582	viral genome integration into host DNA
DHCVS_RS07200	COG1704	LemA family
DHCVS_RS07205	COG0501	Belongs to the peptidase M48B family
DHCVS_RS07210	COG1045	serine acetyltransferase
DHCVS_RS07215	COG1324	tolerance protein
DHCVS_RS07220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DHCVS_RS07225	COG2226	methyltransferase
DHCVS_RS07235	COG1959	2 iron, 2 sulfur cluster binding
DHCVS_RS07255	COG0805	protein transport
DHCVS_RS07260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DHCVS_RS07265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DHCVS_RS07275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DHCVS_RS07280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DHCVS_RS07290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DHCVS_RS07300	COG4372	Transposase
DHCVS_RS07300	COG1418	mRNA catabolic process
DHCVS_RS07305	COG1692	metallophosphoesterase
DHCVS_RS07310	COG0613	PHP domain protein
DHCVS_RS07315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DHCVS_RS07325	COG1720	tRNA m6t6A37 methyltransferase activity
DHCVS_RS07355	COG1131	(ABC) transporter
DHCVS_RS07360	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DHCVS_RS07390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DHCVS_RS07395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DHCVS_RS07395	COG4651	solute:proton antiporter activity
DHCVS_RS07400	COG1234	tRNA 3'-trailer cleavage
DHCVS_RS07410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DHCVS_RS07420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DHCVS_RS07435	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DHCVS_RS07445	COG3956	TIGRFAM MazG family protein
DHCVS_RS07450	COG2738	Putative neutral zinc metallopeptidase
DHCVS_RS07455	COG0268	Binds directly to 16S ribosomal RNA
DHCVS_RS07460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DHCVS_RS07470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DHCVS_RS07495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DHCVS_RS07500	COG2205	protein histidine kinase activity