locus-tag	class	description
Dform_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Dform_RS00010	COG1122	ATPase activity
Dform_RS00015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Dform_RS00025	COG0310	cobalt ion transport
Dform_RS00040	COG1490	D-aminoacyl-tRNA deacylase activity
Dform_RS00050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Dform_RS00050	COG0426	domain, Protein
Dform_RS00060	COG1858	cytochrome C peroxidase
Dform_RS00090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Dform_RS00095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Dform_RS00100	COG0235	Class ii aldolase
Dform_RS00105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Dform_RS00110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Dform_RS00125	COG0124	histidyl-tRNA synthetase
Dform_RS00150	COG3956	TIGRFAM MazG family protein
Dform_RS00160	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Dform_RS00180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Dform_RS00185	COG2226	methyltransferase
Dform_RS00190	COG1144	Oxidoreductase
Dform_RS00220	COG0285	dihydrofolate synthase activity
Dform_RS00260	COG0012	GTP binding
Dform_RS00275	COG0668	transmembrane transport
Dform_RS00280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Dform_RS00285	COG1331	Highly conserved protein containing a thioredoxin domain
Dform_RS00295	COG0586	Pfam SNARE associated Golgi protein
Dform_RS00305	COG0187	DNA topoisomerase II activity
Dform_RS00315	COG1979	alcohol dehydrogenase
Dform_RS00335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Dform_RS00365	COG0569	domain protein
Dform_RS00380	COG0569	domain protein
Dform_RS00395	COG0306	phosphate transporter
Dform_RS00415	COG0493	'glutamate synthase
Dform_RS00415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Dform_RS00420	COG0543	2 iron, 2 sulfur cluster binding
Dform_RS00460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Dform_RS00470	COG0542	response to heat
Dform_RS00485	COG1959	2 iron, 2 sulfur cluster binding
Dform_RS00490	COG0425	Belongs to the sulfur carrier protein TusA family
Dform_RS00495	COG2210	Belongs to the sulfur carrier protein TusA family
Dform_RS00500	COG1104	cysteine desulfurase activity
Dform_RS00525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Dform_RS00545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Dform_RS00580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Dform_RS00585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Dform_RS00590	COG0215	cysteine-tRNA ligase activity
Dform_RS00595	COG0640	Transcriptional regulator
Dform_RS00610	COG1104	cysteine desulfurase activity
Dform_RS00620	COG1959	2 iron, 2 sulfur cluster binding
Dform_RS00625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Dform_RS00625	COG0617	tRNA 3'-terminal CCA addition
Dform_RS00625	COG3620	sequence-specific DNA binding
Dform_RS00665	COG2226	methyltransferase
Dform_RS00675	COG2226	methyltransferase
Dform_RS00695	COG4106	trans-aconitate 2-methyltransferase activity
Dform_RS00705	COG1610	YqeY-like protein
Dform_RS00730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Dform_RS00735	COG0750	zinc metalloprotease
Dform_RS00760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Dform_RS00770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Dform_RS00780	COG0477	Major facilitator Superfamily
Dform_RS00790	COG0167	dihydroorotate dehydrogenase activity
Dform_RS00805	COG1121	(ABC) transporter
Dform_RS00810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Dform_RS00815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Dform_RS00820	COG0803	Belongs to the bacterial solute-binding protein 9 family
Dform_RS00830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Dform_RS00840	COG0564	pseudouridine synthase activity
Dform_RS00845	COG1420	regulation of RNA biosynthetic process
Dform_RS00850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Dform_RS00860	COG2081	HI0933 family
Dform_RS00865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Dform_RS00875	COG1605	Chorismate mutase
Dform_RS00875	COG0287	Prephenate dehydrogenase
Dform_RS00880	COG1605	Chorismate mutase
Dform_RS00880	COG0077	Prephenate dehydratase
Dform_RS00895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Dform_RS00900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Dform_RS00910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Dform_RS00915	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Dform_RS00920	COG2193	ferroxidase activity
Dform_RS00925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Dform_RS00945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Dform_RS00950	COG0088	Forms part of the polypeptide exit tunnel
Dform_RS00960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Dform_RS00965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Dform_RS00980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Dform_RS00985	COG0255	Belongs to the universal ribosomal protein uL29 family
Dform_RS00990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Dform_RS01020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Dform_RS01030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Dform_RS01035	COG1841	ribosomal large subunit assembly
Dform_RS01045	COG0201	protein transport
Dform_RS01055	COG0024	Methionine aminopeptidase
Dform_RS01075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Dform_RS01085	COG0202	RNA polymerase activity
Dform_RS01090	COG0203	ribosomal protein L17
Dform_RS01095	COG0101	tRNA pseudouridine synthase activity
Dform_RS01115	COG2222	sugar isomerase
Dform_RS01120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Dform_RS01130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Dform_RS01135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Dform_RS01150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Dform_RS01165	COG5002	protein histidine kinase activity
Dform_RS01200	COG0312	modulator of DNA gyrase
Dform_RS01205	COG0312	modulator of DNA gyrase
Dform_RS01210	COG2909	trisaccharide binding
Dform_RS01245	COG0604	alcohol dehydrogenase
Dform_RS01280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Dform_RS01445	COG4974	Belongs to the 'phage' integrase family
Dform_RS01560	COG3480	Lon protease (S16) C-terminal proteolytic domain
Dform_RS01575	COG0785	Cytochrome C biogenesis protein
Dform_RS01640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Dform_RS01650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Dform_RS01730	COG0745	RESPONSE REGULATOR receiver
Dform_RS01735	COG0745	RESPONSE REGULATOR receiver
Dform_RS01740	COG1063	alcohol dehydrogenase
Dform_RS01745	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Dform_RS01750	COG1940	carbohydrate kinase activity
Dform_RS01755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Dform_RS01765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Dform_RS01775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Dform_RS01790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Dform_RS01790	COG1017	nitric oxide dioxygenase activity
Dform_RS01800	COG2197	response regulator
Dform_RS01830	COG4974	Belongs to the 'phage' integrase family
Dform_RS01890	COG1072	(Pantothenic acid kinase))
Dform_RS01915	COG0154	amidase activity
Dform_RS01950	COG1522	sequence-specific DNA binding
Dform_RS01955	COG0436	Aminotransferase
Dform_RS02010	COG2132	Multicopper oxidase
Dform_RS02010	COG2132	Multicopper oxidase
Dform_RS02025	COG1763	Mo-molybdopterin cofactor biosynthetic process
Dform_RS02030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Dform_RS02040	COG0315	cyclic pyranopterin monophosphate synthase activity
Dform_RS02045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Dform_RS02050	COG0521	Mo-molybdopterin cofactor biosynthetic process
Dform_RS02060	COG0746	molybdenum cofactor guanylyltransferase activity
Dform_RS02070	COG0243	molybdopterin cofactor binding
Dform_RS02070	COG3383	formate dehydrogenase (NAD+) activity
Dform_RS02075	COG0437	4 iron, 4 sulfur cluster binding
Dform_RS02075	COG3064	Membrane
Dform_RS02080	COG5557	Pfam Polysulphide reductase, NrfD
Dform_RS02100	COG0745	RESPONSE REGULATOR receiver
Dform_RS02130	COG0159	tryptophan synthase activity
Dform_RS02135	COG0133	tryptophan synthase activity
Dform_RS02150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Dform_RS02180	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Dform_RS02185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Dform_RS02195	COG1032	radical SAM domain protein
Dform_RS02200	COG1032	radical SAM domain protein
Dform_RS02205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Dform_RS02210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Dform_RS02220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Dform_RS02225	COG0439	Biotin carboxylase
Dform_RS02250	COG0745	RESPONSE REGULATOR receiver
Dform_RS02255	COG2205	protein histidine kinase activity
Dform_RS02290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Dform_RS02300	COG0742	ribosomal rna small subunit methyltransferase
Dform_RS02305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Dform_RS02310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Dform_RS02355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Dform_RS02365	COG1959	2 iron, 2 sulfur cluster binding
Dform_RS02385	COG0482	sulfurtransferase activity
Dform_RS02430	COG0745	RESPONSE REGULATOR receiver
Dform_RS02475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Dform_RS02500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Dform_RS02505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Dform_RS02555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Dform_RS02635	COG0592	DNA-directed DNA polymerase activity
Dform_RS02640	COG0577	efflux transmembrane transporter activity
Dform_RS02640	COG1136	(ABC) transporter
Dform_RS02645	COG1136	(ABC) transporter
Dform_RS02665	COG0352	thiamine-phosphate diphosphorylase activity
Dform_RS02700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Dform_RS02705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Dform_RS02715	COG0745	RESPONSE REGULATOR receiver
Dform_RS02720	COG2205	protein histidine kinase activity
Dform_RS02735	COG3070	regulator of competence-specific genes
Dform_RS02750	COG2746	aminoglycoside 3-N-acetyltransferase activity
Dform_RS02755	COG0519	Catalyzes the synthesis of GMP from XMP
Dform_RS02760	COG2309	aminopeptidase activity
Dform_RS02765	COG0456	acetyltransferase
Dform_RS02765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Dform_RS02775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Dform_RS02780	COG1993	acr, cog1993
Dform_RS02785	COG2204	response regulator
Dform_RS02790	COG4191	Histidine kinase
Dform_RS02795	COG1872	DUF167
Dform_RS02805	COG1546	Belongs to the CinA family
Dform_RS02805	COG1058	Belongs to the CinA family
Dform_RS02820	COG1032	radical SAM domain protein
Dform_RS02825	COG1063	alcohol dehydrogenase
Dform_RS02835	COG1830	Aldolase
Dform_RS02855	COG0587	DNA-directed DNA polymerase activity
Dform_RS02875	COG0561	phosphatase activity
Dform_RS02900	COG0322	excinuclease ABC activity
Dform_RS02905	COG0717	Belongs to the dCTP deaminase family
Dform_RS02915	COG1960	acyl-CoA dehydrogenase activity
Dform_RS02925	COG2133	pyrroloquinoline quinone binding
Dform_RS02930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Dform_RS02940	COG1461	Dihydroxyacetone kinase
Dform_RS02945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Dform_RS02965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Dform_RS02975	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Dform_RS02980	COG2204	response regulator
Dform_RS02995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Dform_RS03000	COG3259	Nickel-dependent hydrogenase
Dform_RS03050	COG2211	Major facilitator Superfamily
Dform_RS03055	COG0745	RESPONSE REGULATOR receiver
Dform_RS03060	COG2205	protein histidine kinase activity
Dform_RS03090	COG0674	pyruvate-flavodoxin oxidoreductase activity
Dform_RS03090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Dform_RS03095	COG1013	pyruvate-flavodoxin oxidoreductase activity
Dform_RS03100	COG1832	CoA-binding protein
Dform_RS03105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Dform_RS03110	COG1333	cytochrome c biogenesis protein
Dform_RS03125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Dform_RS03140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Dform_RS03160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Dform_RS03165	COG0598	Magnesium transport protein CorA
Dform_RS03175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Dform_RS03180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Dform_RS03190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Dform_RS03195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Dform_RS03200	COG0697	spore germination
Dform_RS03220	COG2197	response regulator
Dform_RS03230	COG0071	Belongs to the small heat shock protein (HSP20) family
Dform_RS03245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Dform_RS03250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Dform_RS03260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Dform_RS03270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Dform_RS03285	COG0426	domain, Protein
Dform_RS03300	COG0697	spore germination
Dform_RS03305	COG0497	DNA recombination
Dform_RS03330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Dform_RS03340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Dform_RS03345	COG0481	GTPase activity
Dform_RS03355	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Dform_RS03370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Dform_RS03375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Dform_RS03390	COG1881	PFAM PEBP family protein
Dform_RS03400	COG0019	diaminopimelate decarboxylase activity
Dform_RS03405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Dform_RS03410	COG1774	PSP1 C-terminal conserved region
Dform_RS03430	COG1484	DNA-dependent DNA replication
Dform_RS03440	COG0305	Participates in initiation and elongation during chromosome replication
Dform_RS03445	COG0359	binds to the 23S rRNA
Dform_RS03450	COG0492	ferredoxin-NADP+ reductase activity
Dform_RS03460	COG1924	4 iron, 4 sulfur cluster binding
Dform_RS03465	COG1473	amidohydrolase
Dform_RS03470	COG1032	radical SAM domain protein
Dform_RS03495	COG1372	Participates in initiation and elongation during chromosome replication
Dform_RS03495	COG0719	Fe-S assembly protein
Dform_RS03500	COG0396	ATPase activity
Dform_RS03510	COG0330	HflC and HflK could
Dform_RS03515	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Dform_RS03515	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Dform_RS03535	COG2197	response regulator
Dform_RS03540	COG4585	Histidine kinase
Dform_RS03550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Dform_RS03565	COG0131	Imidazoleglycerol-phosphate dehydratase
Dform_RS03575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Dform_RS03580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Dform_RS03585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Dform_RS03590	COG0151	Belongs to the GarS family
Dform_RS03600	COG0519	Catalyzes the synthesis of GMP from XMP
Dform_RS03600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Dform_RS03605	COG0009	L-threonylcarbamoyladenylate synthase
Dform_RS03610	COG0698	ribose 5-phosphate isomerase
Dform_RS03620	COG0028	Belongs to the TPP enzyme family
Dform_RS03625	COG0440	acetolactate synthase activity
Dform_RS03635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Dform_RS03640	COG1285	pathogenesis
Dform_RS03645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Dform_RS03650	COG0066	3-isopropylmalate dehydratase activity
Dform_RS03655	COG0473	3-isopropylmalate dehydrogenase activity
Dform_RS03660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Dform_RS03695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Dform_RS03700	COG0084	hydrolase, TatD family'
Dform_RS03710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Dform_RS03715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Dform_RS03720	COG0713	ATP synthesis coupled electron transport
Dform_RS03730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Dform_RS03740	COG0649	NAD binding
Dform_RS03745	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Dform_RS03755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Dform_RS03800	COG0587	DNA-directed DNA polymerase activity
Dform_RS03805	COG0006	proline dipeptidase activity
Dform_RS03810	COG4974	Belongs to the 'phage' integrase family
Dform_RS03815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Dform_RS03820	COG0758	DNA mediated transformation
Dform_RS03825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Dform_RS03830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Dform_RS03830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Dform_RS03845	COG1111	helicase
Dform_RS03845	COG1205	dead DEAH box helicase
Dform_RS03875	COG0475	glutathione-regulated potassium exporter activity
Dform_RS03895	COG0674	pyruvate-flavodoxin oxidoreductase activity
Dform_RS03900	COG1013	pyruvate-flavodoxin oxidoreductase activity
Dform_RS03930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Dform_RS03935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Dform_RS03970	COG0698	ribose 5-phosphate isomerase
Dform_RS04000	COG0740	serine-type endopeptidase activity
Dform_RS04010	COG0142	geranyltranstransferase activity
Dform_RS04030	COG3422	double-strand break repair
Dform_RS04045	COG3422	double-strand break repair
Dform_RS04060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Dform_RS04095	COG4974	Belongs to the 'phage' integrase family
Dform_RS04105	COG0242	peptide deformylase activity
Dform_RS04110	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
Dform_RS04140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Dform_RS04155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Dform_RS04160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Dform_RS04165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Dform_RS04180	COG0126	phosphoglycerate kinase activity
Dform_RS04185	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Dform_RS04195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Dform_RS04200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Dform_RS04205	COG0436	Aminotransferase
Dform_RS04295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Dform_RS04325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Dform_RS04335	COG0228	four-way junction DNA binding
Dform_RS04345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Dform_RS04350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Dform_RS04380	COG0356	it plays a direct role in the translocation of protons across the membrane
Dform_RS04405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Dform_RS04430	COG2197	response regulator
Dform_RS04440	COG0247	lactate metabolic process
Dform_RS04440	COG2181	nitrate reductase activity
Dform_RS04460	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Dform_RS04465	COG0588	phosphoglycerate mutase activity
Dform_RS04470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Dform_RS04480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Dform_RS04495	COG1120	ATPase activity
Dform_RS04500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Dform_RS04515	COG0356	it plays a direct role in the translocation of protons across the membrane
Dform_RS04540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Dform_RS04565	COG2197	response regulator
Dform_RS04575	COG2181	nitrate reductase activity
Dform_RS04575	COG0247	lactate metabolic process
Dform_RS04585	COG3118	belongs to the thioredoxin family
Dform_RS04590	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Dform_RS04595	COG0588	phosphoglycerate mutase activity
Dform_RS04600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Dform_RS04610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Dform_RS04625	COG1120	ATPase activity
Dform_RS04630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Dform_RS04645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Dform_RS04655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Dform_RS04660	COG3259	Nickel-dependent hydrogenase
Dform_RS04665	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Dform_RS04680	COG1233	COG1233 Phytoene dehydrogenase and related
Dform_RS04685	COG2048	Heterodisulfide reductase, subunit B
Dform_RS04700	COG2226	methyltransferase
Dform_RS04720	COG0456	acetyltransferase
Dform_RS04725	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Dform_RS04750	COG0196	riboflavin kinase activity
Dform_RS04765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Dform_RS04785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Dform_RS04795	COG2197	response regulator
Dform_RS04830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Dform_RS04835	COG2205	protein histidine kinase activity
Dform_RS04840	COG0745	RESPONSE REGULATOR receiver
Dform_RS04865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Dform_RS04890	COG3854	ATPases associated with a variety of cellular activities
Dform_RS04910	COG0792	nuclease activity
Dform_RS04915	COG0352	thiamine-phosphate diphosphorylase activity
Dform_RS04925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Dform_RS04935	COG0423	glycine-tRNA ligase activity
Dform_RS04945	COG1187	pseudouridine synthase activity
Dform_RS04955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Dform_RS04960	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Dform_RS04965	COG1131	(ABC) transporter
Dform_RS04975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Dform_RS04980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Dform_RS04990	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Dform_RS04995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Dform_RS05000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Dform_RS05030	COG1131	(ABC) transporter
Dform_RS05035	COG0842	Transport permease protein
Dform_RS05040	COG4585	Histidine kinase
Dform_RS05045	COG2197	response regulator
Dform_RS05080	COG0318	PFAM AMP-dependent synthetase and ligase
Dform_RS05105	COG3320	Male sterility
Dform_RS05105	COG1022	Amp-dependent synthetase and ligase
Dform_RS05110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Dform_RS05120	COG0318	PFAM AMP-dependent synthetase and ligase
Dform_RS05125	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Dform_RS05130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Dform_RS05140	COG0706	membrane insertase activity
Dform_RS05145	COG4993	Dehydrogenase
Dform_RS05150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Dform_RS05155	COG0594	ribonuclease P activity
Dform_RS05160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Dform_RS05165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Dform_RS05170	COG0629	single-stranded DNA binding
Dform_RS05175	COG0360	Binds together with S18 to 16S ribosomal RNA
Dform_RS05185	COG1193	negative regulation of DNA recombination
Dform_RS05195	COG1217	gtp-binding protein TYPA
Dform_RS05200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Dform_RS05210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Dform_RS05210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Dform_RS05220	COG0174	glutamine synthetase
Dform_RS05225	COG3769	mannosylglycerate metabolic process
Dform_RS05235	COG2116	formate transmembrane transporter activity
Dform_RS05240	COG0347	Belongs to the P(II) protein family
Dform_RS05245	COG0004	ammonium transporteR
Dform_RS05250	COG0347	Belongs to the P(II) protein family
Dform_RS05255	COG0004	ammonium transporteR
Dform_RS05260	COG0745	RESPONSE REGULATOR receiver
Dform_RS05270	COG0069	glutamate synthase activity
Dform_RS05280	COG0067	glutamate synthase
Dform_RS05300	COG1971	Probably functions as a manganese efflux pump
Dform_RS05310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Dform_RS05325	COG1181	Belongs to the D-alanine--D-alanine ligase family
Dform_RS05345	COG2205	protein histidine kinase activity
Dform_RS05350	COG0745	RESPONSE REGULATOR receiver
Dform_RS05355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Dform_RS05360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Dform_RS05375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Dform_RS05380	COG0460	homoserine dehydrogenase
Dform_RS05385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Dform_RS05390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Dform_RS05390	COG0574	Belongs to the PEP-utilizing enzyme family
Dform_RS05395	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Dform_RS05400	COG0358	DNA primase activity
Dform_RS05440	COG0419	ATPase involved in DNA repair
Dform_RS05450	COG2267	carboxylic ester hydrolase activity
Dform_RS05465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Dform_RS05480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Dform_RS05495	COG1797	cobyrinic acid a,c-diamide synthase activity
Dform_RS05505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Dform_RS05530	COG0628	permease
Dform_RS05550	COG0463	Glycosyl transferase, family 2
Dform_RS05555	COG0058	SHG alpha-glucan phosphorylase activity
Dform_RS05560	COG1640	4-alpha-glucanotransferase
Dform_RS05595	COG4166	transmembrane transport
Dform_RS05680	COG0305	Participates in initiation and elongation during chromosome replication
Dform_RS05715	COG3383	formate dehydrogenase (NAD+) activity
Dform_RS05720	COG0736	holo-[acyl-carrier-protein] synthase activity
Dform_RS05730	COG0477	Major facilitator Superfamily
Dform_RS05735	COG0217	transcriptional regulatory protein
Dform_RS05765	COG3852	Histidine kinase
Dform_RS05775	COG5002	protein histidine kinase activity
Dform_RS05780	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Dform_RS05785	COG0477	Major facilitator Superfamily
Dform_RS05825	COG0632	four-way junction helicase activity
Dform_RS05835	COG0251	oxidation-reduction process
Dform_RS05870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Dform_RS05885	COG2409	Drug exporters of the RND superfamily
Dform_RS05895	COG1185	polyribonucleotide nucleotidyltransferase activity
Dform_RS05905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Dform_RS05910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Dform_RS05920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Dform_RS05930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Dform_RS05935	COG1980	fructose-bisphosphate aldolase activity
Dform_RS05940	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Dform_RS05950	COG0179	Fumarylacetoacetate (FAA) hydrolase
Dform_RS05955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Dform_RS05960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Dform_RS05970	COG0167	dihydroorotate dehydrogenase activity
Dform_RS05980	COG5002	protein histidine kinase activity
Dform_RS05985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Dform_RS05995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Dform_RS06005	COG1260	myo-inositol-1-phosphate synthase
Dform_RS06010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Dform_RS06020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Dform_RS06025	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Dform_RS06030	COG0195	Participates in both transcription termination and antitermination
Dform_RS06035	COG0606	chelatase, subunit chli
Dform_RS06060	COG0081	regulation of translation
Dform_RS06070	COG0250	Participates in transcription elongation, termination and antitermination
Dform_RS06075	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Dform_RS06105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Dform_RS06110	COG0438	transferase activity, transferring glycosyl groups
Dform_RS06130	COG0444	Belongs to the ABC transporter superfamily
Dform_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Dform_RS06140	COG0601	transmembrane transport
Dform_RS06145	COG4166	transmembrane transport
Dform_RS06180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Dform_RS06180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Dform_RS06200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Dform_RS06205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Dform_RS06210	COG0494	nUDIX hydrolase
Dform_RS06220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Dform_RS06230	COG0537	adenosine 5'-monophosphoramidase activity
Dform_RS06255	COG1598	PFAM Uncharacterised protein family UPF0150
Dform_RS06260	COG0473	3-isopropylmalate dehydrogenase activity
Dform_RS06265	COG0066	3-isopropylmalate dehydratase activity
Dform_RS06280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Dform_RS06290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Dform_RS06300	COG3885	ferrous iron binding
Dform_RS06300	COG2078	PFAM AMMECR1 domain protein
Dform_RS06315	COG0237	dephospho-CoA kinase activity
Dform_RS06330	COG0052	Belongs to the universal ribosomal protein uS2 family
Dform_RS06335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Dform_RS06340	COG0528	UMP kinase activity
Dform_RS06375	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Dform_RS06380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Dform_RS06385	COG0047	phosphoribosylformylglycinamidine synthase activity
Dform_RS06395	COG0516	GMP reductase activity
Dform_RS06400	COG5002	protein histidine kinase activity
Dform_RS06405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Dform_RS06415	COG4968	Prepilin-type N-terminal cleavage methylation domain
Dform_RS06465	COG1459	type II secretion system
Dform_RS06470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Dform_RS06475	COG2201	protein-glutamate methylesterase activity
Dform_RS06530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Dform_RS06545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Dform_RS06555	COG0456	acetyltransferase
Dform_RS06565	COG1132	(ABC) transporter
Dform_RS06575	COG0477	Major facilitator Superfamily
Dform_RS06590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Dform_RS06595	COG2890	protein-(glutamine-N5) methyltransferase activity
Dform_RS06600	COG2086	electron transfer activity
Dform_RS06605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Dform_RS06620	COG3842	ATPase activity
Dform_RS06625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Dform_RS06640	COG4974	Belongs to the 'phage' integrase family
Dform_RS06645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Dform_RS06665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Dform_RS06670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Dform_RS06700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Dform_RS06790	COG2409	Drug exporters of the RND superfamily
Dform_RS06820	COG0535	radical SAM domain protein
Dform_RS06840	COG0488	(ABC) transporter
Dform_RS06920	COG0714	Associated with various cellular activities
Dform_RS06935	COG1305	Transglutaminase-like
Dform_RS06945	COG1126	abc transporter atp-binding protein
Dform_RS06950	COG0765	amino acid transport
Dform_RS06960	COG1174	glycine betaine transport
Dform_RS06970	COG1174	glycine betaine transport
Dform_RS06975	COG1732	Glycine betaine
Dform_RS07000	COG2968	Membrane
Dform_RS07005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Dform_RS07010	COG1131	(ABC) transporter
Dform_RS07025	COG0681	Belongs to the peptidase S26 family
Dform_RS07030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Dform_RS07045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Dform_RS07060	COG0540	Belongs to the ATCase OTCase family
Dform_RS07065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Dform_RS07070	COG0505	Belongs to the CarA family
Dform_RS07075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Dform_RS07080	COG0543	2 iron, 2 sulfur cluster binding
Dform_RS07085	COG2081	HI0933 family
Dform_RS07090	COG0205	6-phosphofructokinase activity
Dform_RS07100	COG4585	Histidine kinase
Dform_RS07105	COG2197	response regulator
Dform_RS07115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Dform_RS07120	COG0297	glycogen (starch) synthase activity
Dform_RS07135	COG2132	Multicopper oxidase
Dform_RS07145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Dform_RS07150	COG1324	tolerance protein
Dform_RS07155	COG1045	serine acetyltransferase
Dform_RS07165	COG1151	hydroxylamine reductase activity
Dform_RS07175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Dform_RS07205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Dform_RS07265	COG2205	protein histidine kinase activity
Dform_RS07270	COG0745	RESPONSE REGULATOR receiver
Dform_RS07275	COG3620	sequence-specific DNA binding
Dform_RS07300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Dform_RS07330	COG1307	EDD domain protein, DegV family
Dform_RS07335	COG0477	Major facilitator Superfamily
Dform_RS07340	COG1846	Transcriptional regulator
Dform_RS07345	COG2226	methyltransferase
Dform_RS07365	COG1132	(ABC) transporter
Dform_RS07370	COG0778	Nitroreductase
Dform_RS07385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Dform_RS07395	COG4895	conserved protein (DUF2196)
Dform_RS07400	COG1363	Peptidase, m42
Dform_RS07430	COG1704	LemA family
Dform_RS07435	COG0501	Belongs to the peptidase M48B family
Dform_RS07440	COG0513	Belongs to the DEAD box helicase family
Dform_RS07445	COG1307	EDD domain protein, DegV family
Dform_RS07455	COG0477	Major facilitator Superfamily
Dform_RS07505	COG0140	phosphoribosyl-ATP diphosphatase activity
Dform_RS07505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Dform_RS07510	COG3872	metal-dependent enzyme
Dform_RS07515	COG0254	rRNA binding
Dform_RS07530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Dform_RS07550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Dform_RS07555	COG1597	lipid kinase activity
Dform_RS07560	COG1595	DNA-templated transcription, initiation
Dform_RS07570	COG5487	UPF0391 membrane protein
Dform_RS07595	COG1131	(ABC) transporter
Dform_RS07600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
Dform_RS07605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Dform_RS07610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Dform_RS07630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Dform_RS07635	COG1573	uracil-dna glycosylase
Dform_RS07645	COG1295	ribonuclease BN
Dform_RS07675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Dform_RS07680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Dform_RS07705	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Dform_RS07720	COG1024	Enoyl-CoA hydratase
Dform_RS07725	COG1250	3-hydroxyacyl-CoA dehydrogenase
Dform_RS07735	COG0730	response to heat
Dform_RS07740	COG0598	Magnesium transport protein CorA
Dform_RS07765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Dform_RS07765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Dform_RS07770	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Dform_RS07785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Dform_RS07810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Dform_RS07815	COG1160	GTP binding
Dform_RS07825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Dform_RS07830	COG0484	heat shock protein binding
Dform_RS07845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Dform_RS07850	COG4585	Histidine kinase
Dform_RS07865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Dform_RS07870	COG1307	EDD domain protein, DegV family
Dform_RS07880	COG0745	RESPONSE REGULATOR receiver
Dform_RS07890	COG2197	response regulator
Dform_RS07905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Dform_RS07905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Dform_RS07910	COG0671	phosphoesterase, PA-phosphatase related
Dform_RS07915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Dform_RS07920	COG1794	racemase activity, acting on amino acids and derivatives
Dform_RS07925	COG0442	prolyl-tRNA aminoacylation
Dform_RS07945	COG1414	Transcriptional regulator
Dform_RS07945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Dform_RS07995	COG1073	alpha beta
Dform_RS08020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Dform_RS08025	COG0581	inorganic phosphate transmembrane transporter activity
Dform_RS08035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Dform_RS08040	COG1803	Methylglyoxal synthase
Dform_RS08045	COG5002	protein histidine kinase activity
Dform_RS08060	COG0745	RESPONSE REGULATOR receiver
Dform_RS08065	COG0432	Pfam Uncharacterised protein family UPF0047
Dform_RS08070	COG1793	dna ligase
Dform_RS08070	COG3285	dna ligase
Dform_RS08130	COG0531	amino acid
Dform_RS08140	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Dform_RS08145	COG0789	Transcriptional regulator
Dform_RS08185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Dform_RS08195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Dform_RS08220	COG1131	(ABC) transporter
Dform_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
Dform_RS08235	COG0745	RESPONSE REGULATOR receiver
Dform_RS08240	COG2205	protein histidine kinase activity
Dform_RS08240	COG2202	Pas domain
Dform_RS08245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Dform_RS08260	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Dform_RS08270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Dform_RS08275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Dform_RS08315	COG0784	Response regulator, receiver
Dform_RS08315	COG4191	Histidine kinase
Dform_RS08335	COG4589	Belongs to the CDS family
Dform_RS08340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Dform_RS08360	COG2217	Heavy metal translocating P-type atpase
Dform_RS08395	COG2314	TM2 domain
Dform_RS08460	COG2197	response regulator
Dform_RS08480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Dform_RS08625	COG4974	Belongs to the 'phage' integrase family
Dform_RS08665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Dform_RS08670	COG3177	Filamentation induced by cAMP protein fic
Dform_RS08705	COG2801	Transposase and inactivated derivatives
Dform_RS08715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Dform_RS08720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Dform_RS08740	COG1752	Esterase of the alpha-beta hydrolase superfamily
Dform_RS08755	COG2409	Drug exporters of the RND superfamily
Dform_RS08760	COG1307	EDD domain protein, DegV family
Dform_RS08845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Dform_RS08850	COG0113	porphobilinogen synthase activity
Dform_RS08860	COG0181	hydroxymethylbilane synthase activity
Dform_RS08865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Dform_RS08870	COG1648	precorrin-2 dehydrogenase activity
Dform_RS08870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Dform_RS08880	COG0535	radical SAM domain protein
Dform_RS08885	COG1122	ATPase activity
Dform_RS08895	COG0310	cobalt ion transport
Dform_RS08900	COG0310	cobalt ion transport
Dform_RS08915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Dform_RS08950	COG0745	RESPONSE REGULATOR receiver
Dform_RS08955	COG5002	protein histidine kinase activity
Dform_RS08960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Dform_RS08995	COG0714	Associated with various cellular activities
Dform_RS09010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Dform_RS09015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Dform_RS09020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Dform_RS09040	COG0673	inositol 2-dehydrogenase activity
Dform_RS09105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Dform_RS09135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Dform_RS09165	COG0571	ribonuclease III activity
Dform_RS09170	COG1254	Belongs to the acylphosphatase family
Dform_RS09175	COG0204	Acyl-transferase
Dform_RS09195	COG0180	Tryptophanyl-tRNA synthetase
Dform_RS09200	COG0788	formyltetrahydrofolate deformylase activity
Dform_RS09230	COG3189	MarR family transcriptional regulator
Dform_RS09235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Dform_RS09240	COG0649	NAD binding
Dform_RS09245	COG0651	ATP synthesis coupled electron transport
Dform_RS09260	COG0651	ATP synthesis coupled electron transport
Dform_RS09265	COG1193	negative regulation of DNA recombination
Dform_RS09295	COG2199	diguanylate cyclase activity
Dform_RS09295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Dform_RS09305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Dform_RS09310	COG1862	Preprotein translocase
Dform_RS09315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Dform_RS09350	COG0799	negative regulation of ribosome biogenesis
Dform_RS09365	COG0105	UTP biosynthetic process
Dform_RS09370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Dform_RS09375	COG0802	atpase or kinase
Dform_RS09380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Dform_RS09405	COG2197	response regulator
Dform_RS09425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Dform_RS09435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Dform_RS09445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Dform_RS09465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Dform_RS09470	COG1592	Rubrerythrin
Dform_RS09475	COG2197	response regulator
Dform_RS09485	COG1744	ABC transporter substrate-binding protein PnrA-like
Dform_RS09500	COG0437	4 iron, 4 sulfur cluster binding
Dform_RS09515	COG5557	Pfam Polysulphide reductase, NrfD
Dform_RS09530	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Dform_RS09535	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Dform_RS09550	COG1924	4 iron, 4 sulfur cluster binding
Dform_RS09555	COG2201	protein-glutamate methylesterase activity
Dform_RS09560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Dform_RS09570	COG2205	protein histidine kinase activity
Dform_RS09575	COG0745	RESPONSE REGULATOR receiver
Dform_RS09580	COG0745	RESPONSE REGULATOR receiver
Dform_RS09590	COG1918	ferrous iron import across plasma membrane
Dform_RS09590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Dform_RS09775	COG4974	Belongs to the 'phage' integrase family
Dform_RS09795	COG4974	Belongs to the 'phage' integrase family
Dform_RS09935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Dform_RS09935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Dform_RS10015	COG0175	sulfate reduction
Dform_RS10055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Dform_RS10055	COG4651	solute:proton antiporter activity
Dform_RS10060	COG3409	Peptidoglycan-binding domain 1 protein
Dform_RS10060	COG0793	Belongs to the peptidase S41A family
Dform_RS10080	COG0003	Pfam Anion-transporting ATPase
Dform_RS10125	COG0735	belongs to the Fur family
Dform_RS10140	COG1704	LemA family
Dform_RS10245	COG4585	Histidine kinase
Dform_RS10265	COG2226	methyltransferase
Dform_RS10275	COG0556	nucleotide-excision repair
Dform_RS10280	COG1943	Transposase
Dform_RS10285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Dform_RS10290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Dform_RS10310	COG0336	Belongs to the RNA methyltransferase TrmD family
Dform_RS10320	COG0335	large ribosomal subunit rRNA binding
Dform_RS10325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Dform_RS10330	COG0617	tRNA 3'-terminal CCA addition
Dform_RS10335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Dform_RS10340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Dform_RS10345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Dform_RS10350	COG2852	Protein conserved in bacteria
Dform_RS10365	COG2337	Toxic component of a toxin-antitoxin (TA) module
Dform_RS10380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Dform_RS10390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Dform_RS10405	COG0542	response to heat
Dform_RS10415	COG0484	heat shock protein binding
Dform_RS10420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Dform_RS10425	COG0138	bifunctional purine biosynthesis protein purh
Dform_RS10455	COG0406	alpha-ribazole phosphatase activity
Dform_RS10460	COG0501	Belongs to the peptidase M48B family
Dform_RS10470	COG4536	flavin adenine dinucleotide binding
Dform_RS10475	COG0309	Hydrogenase expression formation protein (HypE)
Dform_RS10485	COG0298	carbon dioxide binding
Dform_RS10490	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Dform_RS10500	COG0375	protein maturation
Dform_RS10510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Dform_RS10515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Dform_RS10520	COG0612	Peptidase, M16
Dform_RS10530	COG4152	abc transporter atp-binding protein
Dform_RS10535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Dform_RS10585	COG1309	transcriptional regulator
Dform_RS10650	COG1752	Esterase of the alpha-beta hydrolase superfamily
Dform_RS10665	COG1131	(ABC) transporter
Dform_RS10705	COG2003	Belongs to the UPF0758 family
Dform_RS10740	COG2217	Heavy metal translocating P-type atpase
Dform_RS10785	COG0709	Synthesizes selenophosphate from selenide and ATP
Dform_RS10790	COG1921	L-seryl-tRNASec selenium transferase activity
Dform_RS10805	COG1477	protein flavinylation
Dform_RS10810	COG0493	'glutamate synthase
Dform_RS10820	COG0805	protein transport
Dform_RS10825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Dform_RS10830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Dform_RS10835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Dform_RS10840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Dform_RS10845	COG0720	synthase
Dform_RS10865	COG0613	PHP domain protein
Dform_RS10870	COG1692	metallophosphoesterase
Dform_RS10875	COG1418	mRNA catabolic process
Dform_RS10875	COG4372	Transposase
Dform_RS10905	COG1943	Transposase
Dform_RS10920	COG4481	Protein conserved in bacteria
Dform_RS10930	COG0284	orotidine-5'-phosphate decarboxylase activity
Dform_RS10940	COG0798	PFAM Bile acid sodium symporter
Dform_RS10945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Dform_RS10950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Dform_RS10955	COG2738	Putative neutral zinc metallopeptidase